Osteonecrosis due to drugs

OSTEON_DRUGS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M87.1#

1 out of 7 registries used, show all original rules.

658

4. Check minimum number of events

None

658

5. Include endpoints

None

658

6. Filter based on genotype QC (FinnGen only)

520

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1822 909 908
Only index persons 1748 891 857
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 67.96 67.79 68.14
Only index persons 68.30 68.00 68.61

-FinnGen-

Key figures

All Female Male
Number of individuals 520 269 251
Unadjusted period prevalence (%) 0.10 0.10 0.12
Median age at first event (years) 71.00 70.10 71.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
548
Matched controls
5480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M87.1
ICD-10 Finland
Osteonecrosis due to drugs
+∞
307.7
548
*
M05BX04
ATC
denosumab; parenteral
43.2
307.7
346
209
ECB20
NOMESCO Finland
Oral alveoplasty
88.1
286.2
153
24
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
45.2
272.6
170
54
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
59.7
242.4
139
31
WF049
NOMESCO Finland
Radiotherapy of metastasis
22.4
206.8
169
107
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
20.3
198.4
171
120
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
47.7
185.2
111
29
H02AB02
ATC
dexamethasone; systemic
11.5
184.0
276
445
163
Kela drug reimbursment
Abiraterone and enzalutamide
60.4
161.0
91
18
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
14.5
159.6
465
1528
N02AA05
ATC
oxycodone; systemic
8.9
149.1
329
793
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
59.2
143.0
81
16
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
52.5
132.6
77
17
L02BB04
ATC
enzalutamide; oral
55.0
132.2
76
16
SAA03
NOMESCO Finland
Extended examination of mouth
9.3
126.7
427
1511
352
Kela drug reimbursment
Abiraterone and enzalutamide
61.6
124.7
70
13
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
13.7
122.0
126
117
L02BX03
ATC
abiraterone; oral
50.0
119.4
70
16
L02BA03
ATC
fulvestrant; parenteral
52.5
119.0
69
15
JN4AD
NOMESCO Finland
Body CT examination
7.2
107.2
217
457
A03FA01
ATC
metoclopramide; systemic, rectal
6.4
105.3
305
898
WZC00
NOMESCO Finland
Treatment plan or consultation
6.7
98.6
397
1539
1501
Kela drug reimbursment
Palbociclib
52.9
98.6
57
12
Z51.5
ICD-10 Finland
Palliative care
7.3
97.4
183
354
ZX112
NOMESCO Finland
Subcutaneous
15.4
97.0
90
69
394
Kela drug reimbursment
Palbociclib
55.5
96.1
55
11
153
Kela drug reimbursment
Lenalidomid
45.3
95.2
57
14
L04AX04
ATC
lenalidomide; oral
45.3
95.2
57
14
NK6AN
NOMESCO Finland
Total body bone isotope imaging
13.6
91.0
91
79
192
Kela drug reimbursment
Fulvestrant
56.1
89.3
51
10
A04AA01
ATC
ondansetron; systemic, rectal
7.3
88.7
159
291
C90.0
ICD-10 Finland
Multiple myeloma
25.8
86.9
62
27
116
Kela drug reimbursment
Prostate cancer
8.6
86.4
126
183
L02BX02
ATC
degarelix; parenteral
28.8
83.4
57
22
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
26.9
82.7
58
24
Y77
ICPC
Malignant neoplasm prostate
11.3
82.2
93
97
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
22.3
79.4
60
30
329
Kela drug reimbursment
Lenalidomide
50.1
78.7
46
10
ZX120
NOMESCO Finland
Intravenous
6.5
76.8
153
308
A04AA02
ATC
granisetron; systemic, transdermal
7.2
76.6
133
233
L03AA02
ATC
filgrastim; parenteral
11.2
76.6
87
91
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
5.3
75.1
389
1725
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.8
74.6
177
419
L02BB03
ATC
bicalutamide; oral
12.3
73.0
77
72
A79
ICPC
Malignancy NOS
16.8
72.8
63
42
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
23.8
71.0
52
24
L02BG06
ATC
exemestane; oral
14.3
69.5
66
52
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
8.5
67.0
95
132
JN4BD
NOMESCO Finland
Extensive body CT
5.4
66.4
165
403
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
29.8
65.4
44
16
R50.9
ICD-10 Finland
Fever, unspecified
4.8
61.0
185
529
X76
ICPC
Malignant neoplasm breast female
12.6
60.6
62
55
L02AE02
ATC
leuprorelin; implant, parenteral
7.6
59.8
93
143
M87.9
ICD-10 Finland
Osteonecrosis, unspecified
25.2
58.8
42
18
XW000
NOMESCO Finland
Bone marrow biopsy
7.8
57.3
87
130
WW500
NOMESCO Finland
Blood transfusion
7.9
57.2
85
124
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
7.2
55.9
92
150
L03AA13
ATC
pegfilgrastim; parenteral
7.0
54.4
91
151
WF004
NOMESCO Finland
Palliative radiotherapy
11.9
53.0
56
52
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
3.8
52.6
261
1048
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
4.9
51.2
135
341
C61
ICD-10 Finland
Malignant neoplasm of prostate
4.9
50.8
137
352
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
5.9
48.6
99
199
K10.25
ICD-10 Finland
Sequences of jawbones
67.7
48.3
55
9
115
Kela drug reimbursment
Breast cancer
5.0
47.0
119
289
K10.20
ICD-10 Finland
Osteomyelitis (neonatal) of jaw (acute)(chronic)(suppurative)
256.5
46.8
47
*
H02AB06
ATC
prednisolone; systemic
3.6
43.4
377
2083
A06AH03
ATC
naloxegol; oral
13.8
43.0
41
32
M87.0
ICD-10 Finland
Idiopathic aseptic necrosis of bone
16.5
42.9
37
24
XX3DW
NOMESCO Finland
Time consuming IT work
4.1
42.5
142
426
EBA10
NOMESCO Finland
Operative extraction of tooth
4.6
41.2
116
305
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
5.8
40.2
81
160
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.5
39.7
69
118
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
14.7
39.4
36
26
L02BG04
ATC
letrozole; oral
4.9
39.0
96
226
NF1AA
NOMESCO Finland
Hip X-ray examination
4.3
38.7
120
339
L02BA01
ATC
tamoxifen; oral
6.2
37.7
69
124
WZC30
NOMESCO Finland
Teaching
3.5
37.3
174
648
L01EF01
ATC
palbociclib; oral
64.8
36.7
42
7
K10.21
ICD-10 Finland
Osteoradionecrosis of jaw (acute)(chronic)(suppurative)
86.2
36.3
40
5
L95
ICPC
Osteoporosis
5.8
36.2
72
140
B03XA02
ATC
darbepoetin alfa; parenteral
9.4
35.0
43
49
M05BA04
ATC
alendronic acid; oral
4.2
34.6
107
300
EDW99
NOMESCO Finland
Other operation on mandible
69.8
34.5
39
6
L01XE33
ATC
[U] palbociclib
69.8
34.5
39
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
34.1
387
2360
SXC05
NOMESCO Finland
Other oral or dental procedure
5.2
33.3
74
159
C03CA01
ATC
furosemide; systemic
2.9
33.3
269
1359
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
32.2
202
886
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
7.9
31.8
45
61
HAC20
NOMESCO Finland
Total mastectomy
5.9
31.7
60
111
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.9
31.2
104
307
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
4.6
30.9
82
204
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.9
30.6
361
2192
EDA10
NOMESCO Finland
Biopsy of mandible
+∞
30.5
29
*
YN7AD
NOMESCO Finland
CT examination of spine for dose design of radiotherapy
72.2
30.2
34
5
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.8
30.1
58
109
N03AX16
ATC
[U] pregabalin
2.9
29.9
199
895
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
5.8
29.6
57
107
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.8
29.5
317
1823
H02AB09
ATC
hydrocortisone; systemic
8.5
29.3
39
49
D70.82
ICD-10 Finland
Drug-induced neutropenia
9.3
29.2
36
41
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.3
29.2
84
222
A28
ICPC
Limited function/disability NOS
2.9
28.9
181
786
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.7
28.9
72
170
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.5
28.7
116
389
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.3
28.5
134
493
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
28.3
132
483
127
Kela drug reimbursment
Transplant complication
10.9
28.2
31
30
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
27.9
218
1061
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
27.1
27.9
38
15
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.0
27.6
63
138
5BA08, ,
NOMESCO Finland
32.0
27.6
36
12
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
27.3
182
814
A02BC02
ATC
pantoprazole; systemic
3.5
26.9
460
3298
L04AA06
ATC
mycophenolic acid; systemic
9.0
26.9
34
40
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
8.1
26.2
36
47
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
5.1
26.1
58
124
L04AX06
ATC
pomalidomide; oral
46.8
25.8
31
7
M05BA06
ATC
ibandronic acid; systemic
7.3
25.8
39
57
393
Kela drug reimbursment
Pomalidomide
37.6
25.5
32
9
J01FF01
ATC
clindamycin; systemic
2.6
25.3
213
1066
L04AD01
ATC
ciclosporin; systemic
9.6
24.9
30
33
K08.3
ICD-10 Finland
Retained dental root
3.8
24.9
85
253
1507
Kela drug reimbursment
Pomalidomide
36.4
24.5
31
9
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.1
24.4
72
193
SAA02
NOMESCO Finland
Basic examination of mouth
2.8
24.3
410
2831
L02BG03
ATC
anastrozole; oral
8.4
24.1
32
40
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.6
24.1
215
1101
K05.31
ICD-10 Finland
Periodontitis pronounced
3.2
24.1
111
401
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.2
24.0
115
425
EBA00
NOMESCO Finland
Extraction of tooth
2.5
24.0
257
1433
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.8
23.8
38
59
EFA20
NOMESCO Finland
Decortication of jaws
+∞
23.1
22
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.6
22.9
84
262
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
5.6
22.9
45
86
ZYC01
NOMESCO Finland
Remote contact by phone
4.1
22.9
69
188
SAA01
NOMESCO Finland
Simple examination of mouth
2.9
22.8
438
3171
L01BC06
ATC
capecitabine; oral
4.7
22.8
55
126
C50.99
ICD-10 Finland
Breast, unspecified
5.7
22.5
43
80
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
5.9
22.1
41
74
NF3AA
NOMESCO Finland
Femur X-ray examination
6.2
22.1
39
67
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
8.1
21.9
30
39
N02AX02
ATC
tramadol; systemic, rectal
2.4
21.7
305
1892
B01AB05
ATC
enoxaparin; parenteral
2.4
21.3
244
1383
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
6.6
21.3
35
56
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
4.0
21.2
65
179
1523, ,
Kela drug reimbursment
29.4
21.1
28
10
3054, ,
Kela drug reimbursment
29.4
21.1
28
10
J01MA12
ATC
levofloxacin; systemic
2.6
21.1
154
709
ZX090
NOMESCO Finland
Other technic of radiotherapy
5.2
21.0
45
93
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
4.3
20.8
57
144
318
Kela drug reimbursment
Teriparatide
31.5
20.7
27
9
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.7
20.7
40
75
SPAT1254
SPAT
Administration of medicine
2.8
20.7
125
522
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
26.7
20.6
28
11
L01CA04
ATC
vinorelbine; systemic
16.9
20.3
32
20
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
8.3
20.2
27
34
YN7BD
NOMESCO Finland
Extensive CT examination of spine for dose design of radiotherapy
59.9
20.0
23
*
L04AX01
ATC
azathioprine; systemic
5.1
20.0
44
93
5BX04, ,
NOMESCO Finland
+∞
19.9
19
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
19.6
113
459
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
5.3
19.5
41
83
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
19.2
125
541
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.3
19.1
80
271
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
19.1
101
392
N02AJ06
ATC
codeine and paracetamol; systemic
2.2
19.0
293
1855
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
4.8
19.0
44
97
A06AD11
ATC
lactulose; oral
2.7
19.0
124
537
SPF20
NOMESCO Finland
Temporary relining of dentures
21.8
18.8
27
13
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
6.2
18.4
32
54
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.4
18.4
37
72
EDB00
NOMESCO Finland
Partial excision of mandible
45.7
18.4
22
5
WX110
NOMESCO Finland
Infiltration anesthesia
2.5
18.2
430
3228
H02AB07
ATC
prednisone; oral
2.8
18.2
109
451
H05AA02
ATC
teriparatide; parenteral
34.2
18.1
23
7
EBA12
NOMESCO Finland
Demanding operative extraction of tooth
6.3
18.0
31
52
WW200
NOMESCO Finland
Immunization
5.9
17.9
33
59
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
5.4
17.9
36
70
WVA30, ,
SPAT
3.5
17.9
67
211
WX199
NOMESCO Finland
Other local analgesia
4.8
17.8
42
94
A07AA02
ATC
nystatin; oral
3.6
17.7
61
182
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.9
17.6
55
153
B01AB10
ATC
tinzaparin; parenteral
2.8
17.6
100
402
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.2
17.5
49
126
WX290
NOMESCO Finland
Other blockage of nerve
2.2
17.4
278
1767
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
2.2
17.1
332
2270
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
6.0
16.8
30
52
A04AA55
ATC
palonosetron, combinations; systemic
4.4
16.8
43
103
N03AX12
ATC
[U] gabapentin; oral
2.5
16.7
135
645
N02BE01
ATC
paracetamol; systemic, rectal
6.4
16.6
531
4546
L01BA01
ATC
methotrexate; systemic
5.0
16.6
37
79
1CD02, ,
NOMESCO Finland
14.9
16.5
27
19
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
5.1
16.4
35
72
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
5.1
16.4
35
72
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.1
16.3
74
262
NF1DA
NOMESCO Finland
X-ray of hips
5.6
16.1
31
58
M05BA07
ATC
risedronic acid; oral
4.7
15.9
38
86
N05CF01
ATC
zopiclone; oral
2.1
15.7
220
1315
XX7AT
NOMESCO Finland
Radiation therapy with Radium-223
164.5
15.6
16
*
L03AA14
ATC
lipegfilgrastim; parenteral
6.0
15.5
28
49
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
5.7
15.4
29
53
J01DB01
ATC
cefalexin; oral
2.9
15.3
484
3959
J05AB11
ATC
valaciclovir; oral
2.5
15.2
116
538
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
6.7
15.0
24
37
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
6.7
15.0
24
37
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
15.6
15.0
24
16
AA1AD
NOMESCO Finland
CT of head and brain
2.1
15.0
218
1316
NK6AQ
NOMESCO Finland
Whole body bone SPET with low dose CT
32.7
14.9
19
6
R06AE07
ATC
cetirizine; oral
2.0
14.9
259
1669
N02BF02
ATC
pregabalin; oral
3.3
14.9
61
203
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
5.5
14.8
29
55
WW300
NOMESCO Finland
Transfer of autologic stem cells
25.9
14.8
20
8
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
4.8
14.7
34
75
XX7FT
NOMESCO Finland
Radioyttrium therapy with connected antibody
82.4
14.6
16
*
ZXD05
NOMESCO Finland
Urgent procedure
2.1
14.6
187
1075
ECW99
NOMESCO Finland
Other operation on gingiva or alveolar ridge
153.9
14.5
15
*
K10.28
ICD-10 Finland
Other inflammatory condition of the jaws
153.9
14.5
15
*
SAA04
NOMESCO Finland
Special examination of mouth
3.6
14.5
49
144
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
4.8
14.4
33
72
JN4CD
NOMESCO Finland
Very extensive body CT
3.9
14.3
44
121
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.8
14.1
44
122
SPAT1255
SPAT
Intravenous administration of medicine
3.2
14.1
59
199
C77.8
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of multiple regions
16.3
14.0
22
14
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.1
13.9
62
217
ECA99
NOMESCO Finland
Other excision of gingiva or alveolar ridge
54.8
13.9
16
*
XX1XQ
NOMESCO Finland
Other SPECT-CT
+∞
13.6
13
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
13.6
125
627
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
13.5
95
422
K10.26
ICD-10 Finland
Periostitis of jaw (acute)(chronic)(suppurative)
143.4
13.5
14
*
J01MA02
ATC
ciprofloxacin; systemic
2.0
13.5
250
1632
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
3.0
13.5
62
221
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
5.9
13.3
24
42
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.1
13.3
59
206
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.0
13.2
39
104
GD1AD
NOMESCO Finland
Thorax CT examination
2.9
13.1
65
242
K12.2
ICD-10 Finland
Cellulitis and abscess of mouth
13.4
13.0
22
17
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
13.0
83
352
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
23.2
13.0
18
8
EFB10
NOMESCO Finland
Osteoplasty on jaws
51.3
12.9
15
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
2.9
12.9
64
238
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
12.8
95
432
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
12.7
117
585
P01AB01
ATC
metronidazole; oral, rectal
1.9
12.7
245
1613
1515, ,
Kela drug reimbursment
71.6
12.6
14
*
3030
Kela drug reimbursment
Abemaciclib
71.6
12.6
14
*
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
12.5
129
675
GA5AA
NOMESCO Finland
Rib X-ray examination
25.0
12.5
17
7
EEW99
NOMESCO Finland
Other operation on maxilla
132.9
12.5
13
*
Z3231
NOMESCO Finland
Registered nurse
2.0
12.5
181
1078
L04AA01
ATC
[U] ciclosporin
12.0
12.4
22
19
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
6.0
12.4
22
38
J01MA14
ATC
moxifloxacin; systemic
2.7
12.3
74
304
N02AA01
ATC
morphine; systemic, rectal
5.3
12.3
25
49
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.4
12.3
98
461
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.7
12.2
23
42
R4110
NOMESCO Finland
Physiotherapy
2.0
12.1
189
1152
M87.3
ICD-10 Finland
Other secondary osteonecrosis
27.4
12.1
16
6
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
21.9
12.1
17
8
ZXA05
NOMESCO Finland
Left side
2.0
12.0
169
993
L28
ICPC
Limited function/disability (L)
2.1
12.0
144
798
NB6AA
NOMESCO Finland
Humerus X-ray examination
5.0
12.0
26
54
3060, ,
Kela drug reimbursment
47.8
11.9
14
*
1534, ,
Kela drug reimbursment
47.8
11.9
14
*
L02AE03
ATC
goserelin; implant
12.1
11.9
21
18
N02BF01
ATC
gabapentin; oral
2.5
11.9
82
360
J05AB01
ATC
aciclovir; systemic
2.1
11.8
147
825
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
5.7
11.7
22
40
L01EF03
ATC
abemaciclib; oral
66.4
11.6
13
*
SXC03
NOMESCO Finland
Other oral or dental procedure
11.4
11.6
21
19
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
11.6
102
499
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
3.6
11.6
39
114
A46
ICD-10 Finland
Erysipelas
2.2
11.6
110
556
WX704
NOMESCO Finland
Intubation
2.8
11.6
62
240
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.0
11.5
33
86
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.7
11.5
66
265
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
11.4
207
1324
L01FC01
ATC
daratumumab; parenteral
35.8
11.3
14
*
M05BA02
ATC
clodronic acid; systemic
17.5
11.3
17
10
EDA00
NOMESCO Finland
Incision of mandibular abscess
20.5
11.2
16
8
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.7
11.0
65
264
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.0
11.0
147
845
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
3.8
11.0
34
94
WZA90
NOMESCO Finland
Other medical or dental certificate
2.0
10.9
155
909
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
4.5
10.9
27
63
Z01.2
ICD-10 Finland
Dental examination
1.8
10.9
267
1870
Z3226
NOMESCO Finland
Physiotherapist
2.1
10.9
127
695
C50.4
ICD-10 Finland
Malignant neoplasm: Upper-outer quadrant of breast
10.9
10.8
20
19
L04AX03
ATC
methotrexate; systemic
2.5
10.8
73
317
SBB10
NOMESCO Finland
Dental impressions
3.0
10.8
49
173
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.0
10.7
50
179
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.3
10.7
28
68
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
22.0
10.7
15
7
WW409
NOMESCO Finland
Other aferesis
22.0
10.7
15
7
EJ2S1
NOMESCO Finland
Photography of oral mucosa
13.2
10.7
18
14
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
61.2
10.7
12
*
-50
ICPC
Medication/prescr/renewal
3.4
10.6
39
121
WX892
NOMESCO Finland
Monitored bed care
2.6
10.6
63
257
B03XA01
ATC
erythropoietin; parenteral
9.4
10.6
21
23
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
14.6
10.5
17
12
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
12.4
10.4
18
15
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
9.1
10.4
21
24
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.8
10.3
20
21
C77.5
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intrapelvic lymph nodes
23.9
10.3
14
6
TQW40
NOMESCO Finland
Remowal of suture of skin
2.8
10.2
55
213
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
10.2
81
378
J01CA04
ATC
amoxicillin; systemic
2.1
10.2
453
3794
ZX013
NOMESCO Finland
Radiotherapy with large shaped fields - SSD therapy
11.6
10.1
18
16
K02.1
ICD-10 Finland
Caries of dentine
1.8
10.1
323
2430
SPA02
NOMESCO Finland
Preparation for dental prosthetics
3.6
10.0
34
100
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
9.9
47
170
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
9.9
37
116
M16.7
ICD-10 Finland
Other secondary coxarthrosis
12.5
9.9
17
14
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
2.7
9.9
54
211
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.1
9.9
27
68
WX402
NOMESCO Finland
General anaesthesia
2.0
9.8
139
812
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
9.8
190
1229
ZX080
NOMESCO Finland
Image guided radiotherapy
4.3
9.7
25
60
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
4.3
9.7
25
60
C50.9
ICD-10 Finland
Malignant neoplasm: Breast, unspecified
13.7
9.7
16
12
XX9AN
NOMESCO Finland
Complementary isotope examination or additional picture
56.0
9.7
11
*
SPE90
NOMESCO Finland
Other partial denture
4.4
9.7
24
56
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.6
9.6
32
93
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
4.7
9.6
22
48
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
9.6
130
748
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
9.6
67
296
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
4.4
9.5
24
57
R52.2
ICD-10 Finland
Other chronic pain
3.4
9.5
34
104
HA1AA
NOMESCO Finland
X-ray mammography
2.5
9.5
61
259
YNB10
NOMESCO Finland
Collection of stem cells for transplant
101.7
9.4
10
*
M49.5*C79.5
ICD-10 Finland
Metastatic fracture of vertebra
30.6
9.4
12
*
EDB99
NOMESCO Finland
Other excision on mandible
+∞
9.4
9
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
9.4
72
331
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
4.6
9.4
22
49
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.7
9.4
30
85
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
9.8
9.3
18
19
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
9.8
9.3
18
19
S97
ICPC
Chronic ulcer skin
2.5
9.3
60
255
E0000UV, ,
ATC
1.8
9.3
246
1738
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
9.3
262
1885
L04AA13
ATC
[U] leflunomide
4.4
9.2
23
54
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
3.6
9.2
31
91
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.5
9.2
22
50
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.2
9.1
37
122
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
9.1
144
869
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
8.5
9.1
19
23
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.3
9.1
73
342
ZX108
NOMESCO Finland
Inhalation
11.7
9.1
16
14
Z2446
NOMESCO Finland
Social worker
2.7
9.1
50
196
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
4.2
9.1
24
59
1XX32, ,
NOMESCO Finland
37.3
9.0
11
*
ZXA00
NOMESCO Finland
Right side
1.8
9.0
175
1127
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
7.0
8.9
21
31
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.7
8.8
50
199
K04.1
ICD-10 Finland
Necrosis of pulp
2.3
8.7
70
328
EEA10
NOMESCO Finland
Biopsy of maxilla
50.8
8.7
10
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.2
8.7
34
110
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
8.7
76
370
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.7
8.7
20
44
NB1AD
NOMESCO Finland
Shoulder CT examination
4.7
8.7
20
44
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
7.1
8.6
20
29
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
4.2
8.6
23
57
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.2
8.6
35
116
SPAT1088
SPAT
Blood transfusion
16.6
8.6
13
8
WVA30
NOMESCO Finland
Intramuscular and subcutaneous injection
16.6
8.6
13
8
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
8.6
159
1008
WVA20, ,
SPAT
3.2
8.5
33
106
B01AB04
ATC
dalteparin; parenteral
3.0
8.5
38
133
A01
ICPC
Pain general/multiple sites
2.2
8.5
77
380
B74
ICPC
Malignant neoplasm blood other
91.4
8.4
9
*
L01XG03
ATC
ixazomib; oral
91.4
8.4
9
*
L88
ICPC
Rheumatoid/seropositive arthritis
3.2
8.4
34
112
EFB60
NOMESCO Finland
Osteoplasty of jaws or facial bones with use of osseous graft or foreign material
+∞
8.4
8
*
M90.7*C90.0
ICD-10 Finland
Pathological fracture in multiple myeloma
+∞
8.4
8
*
WW402
NOMESCO Finland
Leucoferesis
+∞
8.4
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
8.3
94
504
Z50.1
ICD-10 Finland
Other physical therapy
2.7
8.3
44
169
TQW20
NOMESCO Finland
Tatoe
9.7
8.3
16
17
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.8
8.3
25
68
SFA10
NOMESCO Finland
One-surface restoration
1.7
8.2
302
2306
M81.8
ICD-10 Finland
Other osteoporosis
7.7
8.2
18
24
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
4.5
8.2
20
46
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.6
8.2
27
78
Z2221
NOMESCO Finland
Medical doctor
1.8
8.2
158
1012
JN5ER
NOMESCO Finland
PET-CT of receptors in whole body
11.9
8.1
14
12
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.5
8.1
51
214
M87
ICD-10 Finland
Osteonecrosis
33.9
8.1
10
*
WD215
NOMESCO Finland
Multiple therapy of methastized malignancy with hormones
33.9
8.1
10
*
M87.8
ICD-10 Finland
Other osteonecrosis
33.9
8.1
10
*
N06AX21
ATC
duloxetine; oral
2.2
8.1
75
373
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
3.3
8.1
30
94
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
8.0
211
1472
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
8.0
120
709
RS221, ,
NOMESCO Finland
7.4
8.0
18
25
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.4
8.0
42
947
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.0
8.0
36
127
SCA02
NOMESCO Finland
Preventive oral health care
2.4
7.9
58
261
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
9.6
7.8
15
16
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.0
7.8
99
553
A05AA02
ATC
ursodeoxycholic acid; oral
6.5
7.8
19
30
M49.5*C90.0
ICD-10 Finland
Vertebral fracture due to multiple myeloma
45.6
7.7
9
*
YN1AD
NOMESCO Finland
CT examination of extremities for dose design of radiotherapy
45.6
7.7
9
*
R52.9
ICD-10 Finland
Pain, unspecified
2.2
7.7
70
345
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.5
7.7
50
213
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
7.7
33
113
WX725
NOMESCO Finland
Noninvasive ventilation
2.6
7.6
44
177
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.0
7.6
34
119
M16.6
ICD-10 Finland
Other secondary coxarthrosis, bilateral
25.4
7.6
10
*
WD315
NOMESCO Finland
Multiple therapy of methastized malignancy with biomodifiers
25.4
7.6
10
*
K05.30
ICD-10 Finland
Periodontitis complex
1.9
7.6
105
605
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
7.3
7.5
17
24
TKC20
NOMESCO Finland
Catheterisation of bladder
2.4
7.5
51
222
D70.89
ICD-10 Finland
Neutropenic splenomegaly
6.6
7.5
18
28
R60.0
ICD-10 Finland
Localized oedema
2.0
7.5
92
509
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
81.2
7.4
8
*
SPA47
NOMESCO Finland
Precision impression for denture
3.1
7.4
30
99
C50.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of breast
13.6
7.4
12
9
B82
ICPC
Anaemia other/unspecified
3.2
7.4
29
94
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
8.5
7.4
15
18
WF099
NOMESCO Finland
Other radiotherapy
11.1
7.3
13
12
EFW99
NOMESCO Finland
Other operation on jaws
+∞
7.3
7
*
D63.0
ICD-10 Finland
Anaemia in neoplastic disease
+∞
7.3
7
*
E83.50
ICD-10 Finland
Hypercalcemia
6.4
7.3
18
29
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
4.4
7.3
18
42
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.2
7.2
60
285
ECA20
NOMESCO Finland
Biopsy of gingiva
7.5
7.2
16
22
XKD00
NOMESCO Finland
Uroflowmetry
1.9
7.2
107
629
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.5
7.2
44
182
A41.9
ICD-10 Finland
Sepsis, unspecified
3.1
7.2
30
101
1505
Kela drug reimbursment
Ixazomib
30.4
7.2
9
*
398
Kela drug reimbursment
Ixazomib
30.4
7.2
9
*
AA1AA
NOMESCO Finland
Head X-ray examination
6.7
7.2
17
26
L01EF02
ATC
ribociclib; oral
20.3
7.2
10
5
SBA00
NOMESCO Finland
Microbiological examinations
3.9
7.1
21
56
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
7.1
48
208
D40.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Prostate
6.2
7.1
18
30
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.6
7.1
41
165
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
7.1
58
274
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
8.9
7.1
14
16
NK6BQ
NOMESCO Finland
Whole body extensive bone SPET with low dose CT
8.9
7.1
14
16
K10.3
ICD-10 Finland
Alveolitis of jaws
2.9
7.1
32
113
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
3.3
7.1
26
81
N05BA04
ATC
oxazepam; oral
1.7
7.0
152
999
WF003
NOMESCO Finland
Adjuvant radiotherapy
3.2
7.0
28
92
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
7.0
100
581
ZY010
NOMESCO Finland
Hospital outpatient
2.9
7.0
32
114
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.7
6.9
22
62
130
Kela drug reimbursment
Malignant tumour
2.1
6.9
67
339
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
3.1
6.9
29
98
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
3.9
6.9
20
53
G03HA01
ATC
cyproterone; systemic
8.4
6.9
14
17
EB1CA
NOMESCO Finland
Tooth X-ray additional picture
2.2
6.9
58
278
ZX112, ,
SPAT
11.1
6.8
12
11
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
6.2
6.8
17
28
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
3.2
6.8
26
83
XX7LT
NOMESCO Finland
Lutetium-177-PSMA treatment
40.6
6.8
8
*
L04AX02
ATC
thalidomide; oral
40.6
6.8
8
*
3002
Kela drug reimbursment
Ribociclib
22.8
6.7
9
*
1514, ,
Kela drug reimbursment
22.8
6.7
9
*
EEB00
NOMESCO Finland
Partial excision of maxilla
22.8
6.7
9
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
22.8
6.7
9
*
KE1DR
NOMESCO Finland
Prostate metabolic PET with CT
22.8
6.7
9
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
4.1
6.7
18
45
ZXE00
NOMESCO Finland
One hour or less
1.6
6.7
212
1537
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.4
6.6
46
202
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
6.6
97
567
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
12.4
6.6
11
9
L99
ICPC
Musculoskeletal disease other
3.9
6.6
19
50
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.4
6.6
46
203
EB1WA, ,
NOMESCO Finland
10.2
6.6
12
12
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.9
6.5
88
502
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.5
6.5
42
179
XX7JT
NOMESCO Finland
Somatostatin isotope ablative therapy
70.6
6.4
7
*
K10.29
ICD-10 Finland
Inflammatory condition of the jaws UNS
70.6
6.4
7
*
ECA40
NOMESCO Finland
Surgical treatment of periodontal abscess
70.6
6.4
7
*
M05BA08
ATC
zoledronic acid; parenteral
70.6
6.4
7
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.8
6.4
19
51
WX203
NOMESCO Finland
Infraclavicular plexus blockade
3.8
6.4
19
51
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.3
6.4
49
225
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
4.1
6.4
17
42
Z94.0
ICD-10 Finland
Kidney transplant status
8.3
6.4
13
16
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
3.4
6.3
22
66
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
6.3
98
583
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
11.2
6.3
11
10
NH1AD
NOMESCO Finland
Ankle and foot CT
3.9
6.3
18
47
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.9
6.3
18
47
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.5
6.3
39
163
H02AB04
ATC
methylprednisolone; systemic
1.9
6.3
85
485
1CX01, ,
NOMESCO Finland
27.0
6.2
8
*
N05AD01
ATC
haloperidol; systemic
3.3
6.2
23
72
WX200
NOMESCO Finland
Interscalenous plexus blockade
3.6
6.2
20
57
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.1
6.2
26
88
ECB00
NOMESCO Finland
Suture of gingiva
2.9
6.2
28
99
WZA00
NOMESCO Finland
Concise certificate
2.4
6.2
42
183
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
2.7
6.2
33
128
M81.5
ICD-10 Finland
Idiopathic osteoporosis
7.8
6.2
13
17
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
3.1
6.1
25
83
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
3.8
6.1
18
48
SPAT1263
SPAT
Sampling
1.6
6.1
232
1744
SPAT1229
SPAT
Assessment of need for aid
2.2
6.1
52
250
M81.4
ICD-10 Finland
Drug-induced osteoporosis
12.7
6.1
10
8
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
12.7
6.1
10
8
A11CC03
ATC
alfacalcidol; systemic
3.7
6.1
19
53
J20.5
ICD-10 Finland
Acute bronchitis due to respiratory syncytial virus
8.7
6.1
12
14
ZXC40
NOMESCO Finland
Use of ultrasound
10.2
6.1
11
11
M05BX03
ATC
strontium ranelate; oral
10.2
6.1
11
11
R5110, ,
SPAT
2.0
6.0
64
335
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
4.0
6.0
17
44
D64.8
ICD-10 Finland
Other specified anaemias
4.0
6.0
17
44
TK800
NOMESCO Finland
Hemodialysis
4.0
6.0
17
44
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
6.0
239
1815

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
372
1598
5.13
74.71
7.6
4.4
—
—
—
0
0
502
2802
10.43
72.55
30.2
7.5
1.22
1.21
mmol/l
1.60
458
2436
401
1905
5.12
68.57
12.9
3.6
2.35
2.36
mmol/l
0.60
390
1717
245
812
4.65
67.73
2.4
2.0
—
—
—
0
0
457
2447
6.22
66.03
15.4
5.1
33.43
35.34
g/l
10.39
444
2288
496
2936
8.26
61.18
42.3
10.0
3.90
4.14
e9/l
1.61
474
2548
452
2542
5.44
57.37
21.5
6.7
1.22
1.21
mmol/l
2.87
447
2336
253
949
4.09
57.32
7.7
3.4
0.80
0.82
mmol/l
2.15
246
899
366
1773
4.20
57.01
14.5
6.0
—
—
—
0
0
353
1678
4.10
56.28
16.4
4.3
7.40
7.40
ph
0.12
300
1194
62
62
11.15
55.88
4.3
2.7
—
—
—
0
0
430
2484
4.40
48.55
17.5
6.2
24.57
26.95
%
4.22
421
2343
81
135
6.87
48.00
4.9
1.8
—
—
—
0
0
423
2449
4.19
46.79
17.6
6.2
9.20
8.99
%
0.63
413
2290
422
2448
4.15
46.33
17.5
6.1
2.43
2.86
%
3.95
412
2286
418
2444
3.99
44.51
17.3
6.1
59.49
57.64
%
2.11
411
2327
418
2445
3.99
44.46
17.9
6.2
0.62
0.68
%
1.51
410
2280
97
212
5.34
43.19
21.3
4.2
82.47
74.27
mg/l
0.09
89
180
97
212
5.34
43.19
21.3
4.2
37.92
53.52
mg/l
0.47
89
182
92
194
5.50
42.62
19.4
3.8
16.63
2.35
ratio
1.15
73
108
201
771
3.54
41.76
10.1
5.4
1.04
1.03
mmol/l
0.15
193
709
437
2689
4.09
41.74
16.9
6.1
1.62
1.93
e9/l
4.15
405
2347
431
2642
3.96
41.07
16.8
6.0
0.60
0.60
e9/l
0.15
394
2238
439
2729
4.06
40.83
17.5
6.3
0.17
0.19
e9/l
1.02
408
2355
428
2654
3.80
39.08
16.8
6.0
0.04
0.04
e9/l
2.97
391
2252
217
905
3.31
38.94
3.1
2.5
2.21
2.29
g/l
1.21
207
843
37
29
13.61
38.66
3.9
2.0
—
—
—
0
0
226
974
3.25
38.26
3.2
2.5
12.10
12.65
umol/l
0.51
219
910
422
2635
3.62
37.17
14.3
15.7
1.19
1.27
inr
2.72
369
2186
204
847
3.24
36.49
3.2
2.5
21.25
22.21
%
0.44
197
796
51
69
8.05
36.22
4.1
2.3
0.64
1.24
g/24h
1.16
37
41
135
439
3.75
35.48
8.9
2.6
8.28
10.87
g/l
6.47
130
404
162
612
3.34
33.54
2.3
1.7
—
—
—
0
0
128
418
3.69
33.27
14.9
2.8
—
—
—
0
0
134
453
3.59
33.03
7.2
4.3
0.78
0.51
%
1.31
90
160
461
3148
3.93
32.99
11.4
5.3
6.70
6.76
mmol/l
0.28
451
3016
175
699
3.21
32.95
5.5
2.6
2.06
1.82
%
1.81
170
635
60
110
6.00
32.03
3.1
1.8
—
—
—
0
0
31
25
13.08
31.75
2.5
2.0
55.65
50.46
ug/l
0.20
31
25
95
270
4.05
29.97
2.1
2.0
1.77
1.52
g/l
1.20
87
243
146
552
3.24
29.82
4.7
2.6
73.29
70.69
e9/l
0.33
118
410
91
253
4.11
29.57
2.1
1.9
1.68
3.10
ug/l
0.56
85
223
49
81
6.55
28.95
2.0
1.6
—
—
—
0
0
49
81
6.55
28.95
2.0
1.6
—
—
—
0
0
49
81
6.55
28.95
2.0
1.6
—
—
—
0
0
49
81
6.55
28.95
2.0
1.6
—
—
—
0
0
32
32
10.56
28.52
3.8
1.5
—
—
—
0
0
300
1700
2.69
28.38
4.8
3.4
—
—
—
0
0
109
354
3.60
28.26
3.9
1.7
0.68
1.45
g/l
3.32
97
321
377
2410
2.81
27.73
5.5
2.8
—
—
estimate
—
0
0
474
3457
3.75
27.05
7.8
4.9
—
2.94
—
0
7
307
1803
2.60
26.33
5.5
3.6
436.63
101.90
e6/l
0.43
264
1398
128
481
3.17
26.11
7.7
4.2
1.21
0.85
%
0.78
85
175
227
1162
2.63
25.82
6.6
3.1
2.49
2.46
mmol/l
1.54
210
1046
239
1266
2.57
25.18
3.9
2.7
4.59
5.04
e6/l
0.27
233
1162
120
446
3.16
24.84
4.0
3.3
204.69
202.44
ng/l
0.02
112
411
260
1440
2.53
24.83
2.9
2.3
2.70
3.00
mg/l
1.40
240
1246
150
633
2.89
24.78
7.1
4.6
184.19
29.98
ug/l
0.49
135
534
120
451
3.13
24.34
4.2
3.8
73.42
82.81
ng/l
0.57
105
397
209
1052
2.60
24.33
4.7
3.0
516.60
531.27
mosm/kgh2o
0.48
198
924
129
506
3.03
24.28
3.7
2.0
352.08
384.38
nmol/l
0.86
120
480
39
62
6.70
23.85
1.2
1.2
—
—
—
0
0
28
30
9.78
23.71
3.9
1.7
34.21
34.23
%
0.00
28
30
286
1694
2.44
23.10
8.6
3.4
38.42
33.38
u/l
0.50
273
1591
287
1704
2.44
23.04
5.4
2.5
—
—
—
0
0
98
342
3.27
22.40
1.6
1.4
—
—
—
0
0
124
499
2.92
22.12
1.6
1.4
—
—
—
0
0
318
2011
2.39
21.66
7.1
4.3
81.10
115.14
e6/l
0.56
266
1444
207
1086
2.46
21.56
5.4
4.2
196.40
322.24
ng/l
0.66
171
897
265
1552
2.37
21.51
5.0
3.5
0.42
0.52
e6/l
0.39
227
1151
350
2331
2.39
20.83
3.8
2.5
82.68
78.78
nmol/l
1.96
335
2066
46
98
5.03
20.71
1.7
1.3
—
—
—
0
0
114
453
2.91
20.71
8.2
4.3
0.12
0.13
%
0.10
69
145
116
466
2.89
20.66
8.2
4.7
0.21
0.16
%
0.16
71
134
228
1295
2.30
19.37
4.7
2.5
—
—
—
0
0
339
2276
2.28
19.08
4.4
3.0
279.68
135.57
ug/l
7.67
322
2104
276
1714
2.23
18.69
3.8
2.5
52.56
64.55
u/l
1.94
262
1587
105
428
2.80
18.04
3.1
2.5
4.44
13.57
nmol/l
19.00
84
383
175
912
2.35
17.94
4.6
3.3
3.96
1.88
e6/l
1.29
100
461
98
389
2.85
17.67
4.6
3.8
7.42
7.42
ph
0.03
88
329
183
992
2.27
16.95
5.3
1.4
2.12
2.63
g/l
1.73
136
579
116
514
2.59
16.83
1.8
1.5
—
—
—
0
0
126
592
2.47
16.09
1.9
1.6
—
—
—
0
0
124
579
2.48
16.05
7.9
3.5
1.31
1.90
mmol/l
0.87
106
496
128
609
2.44
15.89
8.0
3.6
7.38
7.38
ph
0.46
80
347
173
956
2.18
14.99
1.7
1.7
1032.47
1214.54
nmol/l
1.90
150
720
47
133
3.77
14.67
1.5
1.2
—
—
—
0
0
49
143
3.66
14.63
4.2
3.3
1.61
1.71
index
0.06
28
86
37
88
4.44
14.56
1.7
1.4
163.43
165.60
au/ml
0.04
14
29
247
1578
2.03
14.41
27.0
6.4
—
—
—
0
0
123
601
2.35
14.25
7.9
2.8
8.26
8.84
umol/l
0.10
112
538
23
36
6.62
14.20
2.0
2.4
27.67
42.39
%
2.57
12
22
27
50
5.63
14.14
1.4
1.2
—
—
—
0
0
38
96
4.18
13.85
1.6
1.2
229.92
268.28
u/ml
0.29
26
50
95
421
2.52
13.60
15.9
3.9
1.24
1.23
mmol/l
0.82
95
362
274
1860
1.95
13.02
4.4
3.3
1978.71
1280.84
ng/l
0.68
256
1618
27
54
5.21
13.02
1.4
1.1
—
—
—
0
0
18
8
23.20
12.97
3.0
2.3
—
—
—
0
0
134
710
2.17
12.64
9.6
7.8
7.42
7.42
ph
0.24
70
410
132
703
2.16
12.25
9.4
7.8
1.55
1.00
mmol/l
0.82
115
600
125
652
2.19
12.23
2.0
1.7
—
—
—
0
0
534
4755
5.82
12.21
59.3
18.0
26.63
25.21
mg/l
0.53
522
3975
169
994
2.01
11.99
4.1
3.2
1.17
1.05
e6/l
0.19
95
544
104
507
2.30
11.96
13.1
8.8
—
—
—
0
0
127
672
2.16
11.96
2.0
1.5
—
—
—
0
0
252
1699
1.89
11.90
2.2
1.7
19.05
20.43
nmol/l
0.86
233
1426
16
7
23.49
11.62
3.3
2.3
—
—
—
0
0
286
2036
1.85
11.13
2.5
2.2
—
—
—
0
0
27
62
4.53
11.10
4.7
3.7
—
—
—
0
0
184
1152
1.90
10.66
2.8
1.7
1.24
1.36
mg/l
0.38
156
919
308
2263
1.82
10.63
33.7
11.8
0.00
0.00
e9/l
0.46
267
1840
66
279
2.55
10.34
5.3
3.8
—
—
—
0
0
37
113
3.44
10.32
3.9
2.8
55.16
58.39
%
0.66
37
113
17
13
13.45
10.22
2.2
2.8
—
—
—
0
0
99
504
2.18
10.16
2.7
2.5
27.74
34.69
u/l
1.62
81
416
29
77
3.92
9.89
1.6
1.3
—
—
—
0
0
173
1096
1.85
9.47
9.9
4.9
—
—
—
0
0
350
2724
1.79
9.46
5.9
4.2
0.00
0.00
estimate
-0.00
96
551
16
13
12.64
9.41
1.5
1.5
—
—
—
0
0
355
2777
1.79
9.41
6.0
4.2
0.00
0.58
estimate
0.52
94
531
32
95
3.52
9.32
1.1
1.1
—
—
—
0
0
35
111
3.30
9.21
1.4
1.2
59.79
22.55
u/l
1.38
35
96
350
2752
1.75
8.84
5.9
4.2
0.00
6.13
estimate
0.80
98
572
115
652
1.97
8.76
6.5
3.3
3.71
4.62
e9/l
1.46
106
560
33
106
3.25
8.52
2.1
1.4
—
—
—
0
0
19
41
4.76
8.41
1.3
1.1
123.74
102.93
pmol/l
0.67
19
41
119
696
1.91
8.23
1.6
1.3
682.58
504.60
titre
0.44
31
161
33
109
3.16
8.15
3.6
3.9
—
—
—
0
0
20
32
6.44
8.08
5.2
2.0
526.93
454.74
e6/l
0.23
15
27
96
526
2.00
8.02
11.6
7.6
1.36
1.32
mmol/l
0.12
96
517
202
1396
1.71
7.94
7.6
3.0
335.60
352.70
umol/l
1.36
190
1217
385
3157
1.74
7.89
4.5
3.4
90.61
52.79
u/l
2.52
373
2952
41
158
2.72
7.72
2.1
1.6
17737.69
16521.32
e6/l
0.04
29
116
23
62
3.83
7.70
2.1
1.3
16.64
28.35
ng/l
1.11
23
62
106
1696
0.54
7.69
3.3
3.5
—
—
—
0
0
13
11
12.07
7.61
1.0
1.1
—
—
—
0
0
314
2454
1.65
7.57
2.7
2.2
88.50
96.55
pmol/l
2.75
213
1280
36
132
2.85
7.43
1.4
2.8
35.22
32.98
umol/l
0.20
36
119
28
90
3.22
7.24
1.1
1.1
—
—
—
0
0
15
19
8.08
7.14
3.9
1.5
—
—
—
0
0
25
76
3.40
7.05
1.4
1.7
0.66
0.90
g/l
0.38
19
65
31
108
2.98
7.01
1.2
1.1
—
—
—
0
0
153
2162
0.59
6.81
2.0
2.0
1.61
1.32
mmol/l
3.02
133
1788
53
247
2.27
6.69
1.3
1.3
—
—
—
0
0
12
12
10.19
6.56
1.3
1.5
32.42
34.67
%
0.11
12
12
16
26
6.30
6.51
1.9
2.3
592.75
912.69
u/ml
1.01
16
26
229
1699
1.60
6.50
2.8
2.2
159.67
241.47
u/l
0.96
219
1611
197
1412
1.62
6.44
4.1
3.2
0.00
0.06
—
6
35
23
72
3.29
6.21
1.2
1.3
7717.80
1650.79
e6/l
0.67
15
47
47
215
2.30
6.21
2.8
1.9
11.57
9.21
iu/ml
—
10
54
46
212
2.28
5.97
1.2
1.3
—
—
—
0
0
45
209
2.26
5.74
3.8
3.4
1204.73
260.98
mg/l
0.58
26
86
28
104
2.78
5.68
2.7
2.8
7.41
9.62
pmol/l
0.43
28
104
278
2203
1.53
5.65
4.7
3.7
6.22
6.22
ph
0.00
141
1199
14
24
5.96
5.56
1.2
1.4
—
—
—
0
0
52
261
2.10
5.49
2.9
2.5
0.00
0.00
estimate
-0.00
17
76
17
48
3.62
5.36
1.1
1.1
—
—
—
0
0
18
55
3.35
5.07
4.1
1.3
—
—
—
0
0
20
66
3.11
4.99
1.2
1.3
6319.27
51282.71
e6/l
1.34
11
35
27
107
2.60
4.87
1.8
1.3
17.54
8.70
u/l
1.63
21
79
267
2142
1.48
4.86
5.3
4.1
30.40
73.10
ng/l
0.88
222
1662
17
52
3.34
4.78
12.6
2.0
9.44
10.33
%
0.39
17
52
8
282
0.27
4.66
1.5
1.4
—
—
—
0
0
28
116
2.49
4.63
1.5
1.2
—
—
—
0
0
538
5129
3.68
4.60
83.1
27.4
246.17
244.33
e9/l
0.20
532
5034
538
5130
3.67
4.58
82.8
27.4
4.02
4.45
e12/l
57.31
531
5015
538
5130
3.67
4.58
82.8
27.4
6.65
6.77
e9/l
0.63
532
5017
46
237
2.03
4.55
1.4
1.6
—
—
—
0
0
22
82
2.75
4.47
4.5
2.8
3.45
4.33
e9/l
1.29
22
82
24
95
2.60
4.35
1.8
2.9
—
—
—
0
0
178
1341
1.48
4.32
1.7
1.3
—
—
—
0
0
10
16
6.34
4.31
3.6
3.6
62.30
51.81
%
—
10
16
8
9
9.00
4.29
1.1
1.3
—
—
—
0
0
188
1434
1.47
4.28
5.3
3.6
0.00
0.06
estimate
0.52
71
444
15
39
3.92
4.22
1.1
1.1
325.00
65.00
titre
—
6
6
13
30
4.41
4.15
1.0
1.0
—
—
—
0
0
77
482
1.70
4.14
2.2
2.6
7.25
6.20
ug/l
0.17
68
430
24
98
2.52
4.10
4.6
4.2
2.31
2.41
mmol/l
0.07
19
65
14
42
3.39
4.07
1.5
1.3
1.55
3.08
g/l
—
9
35
405
3590
1.49
4.04
5.6
4.6
—
0.22
—
0
9
12
27
4.52
3.95
2.8
4.4
89.33
149.89
nmol/l
0.53
12
27
24
100
2.46
3.94
3.8
1.2
—
—
—
0
0
17
59
2.94
3.93
1.1
1.3
—
—
—
0
0
14
43
3.31
3.93
1.5
1.3
—
—
—
0
0
20
77
2.66
3.85
2.6
2.0
33.80
32.52
pg
1.06
20
77
34
168
2.09
3.78
2.1
1.4
210.96
278.01
ug/g
1.26
27
106
15
50
3.06
3.71
3.7
1.2
—
—
—
0
0
9
16
5.70
3.67
3.4
1.4
—
—
—
0
0
17
62
2.80
3.62
1.2
1.5
—
—
—
0
0
11
26
4.30
3.52
1.0
1.0
—
—
—
0
0
8
13
6.23
3.51
1.1
1.2
—
—
—
0
0
8
13
6.23
3.51
1.0
1.0
—
—
—
0
0
87
594
1.55
3.30
3.4
2.2
167.20
138.90
ug/g
0.51
74
465
9
19
4.80
3.25
2.9
1.5
0.60
0.60
mmol/l
—
9
19
11
29
3.85
3.20
1.2
1.1
—
—
—
0
0
7
11
6.43
3.19
1.0
1.0
—
—
—
0
0
43
246
1.81
3.18
1.1
1.2
—
—
—
0
0
15
55
2.78
3.18
1.0
1.2
—
—
—
0
0
145
1111
1.41
3.08
1.4
1.3
0.74
1.36
u/ml
1.43
31
290
6
8
7.57
3.06
7.7
2.1
37.67
32.25
u/l
—
6
8
8
16
5.06
3.06
1.8
1.7
—
—
—
0
0
25
121
2.12
2.97
1.0
1.2
—
—
—
0
0
61
393
1.62
2.96
6.6
4.1
—
—
—
0
0
444
4725
0.68
2.95
4.8
5.4
1.46
1.46
mmol/l
0.00
411
4333
96
688
1.48
2.90
1.3
1.3
—
—
—
0
0
75
511
1.54
2.88
3.1
2.3
0.00
0.00
estimate
-0.00
19
95
457
4832
0.67
2.84
5.4
6.4
2.58
2.62
mmol/l
0.43
427
4447
15
59
2.59
2.81
1.6
1.5
60.58
64.89
%
—
8
46
8
18
4.49
2.80
7.3
2.3
37.73
40.94
g/l
—
8
18
147
1148
1.38
2.77
1.7
1.8
420.54
5319587.19
pmol/l
0.50
130
940
10
29
3.49
2.70
2.0
1.5
—
—
—
0
0
57
372
1.59
2.64
1.2
1.2
—
—
—
0
0
448
4743
0.70
2.62
5.0
5.5
4.56
4.54
mmol/l
0.19
419
4386
26
137
1.94
2.50
3.5
1.2
776.42
505.83
mg/l
0.36
26
130
8
21
3.85
2.47
1.1
1.0
—
—
—
0
0
23
117
2.01
2.44
1.3
1.3
57.00
59.14
mmol/l
0.10
18
101
8
22
3.67
2.37
2.0
1.4
—
—
—
0
0
15
65
2.34
2.33
1.2
1.8
—
—
—
0
0
231
1972
1.30
2.31
4.8
3.8
—
0.71
—
0
7
238
2041
1.29
2.29
6.1
4.1
0.04
0.03
estimate
0.11
80
459
13
53
2.49
2.29
1.5
1.3
323710.00
258895.73
e6/l
—
8
37
418
3863
1.35
2.29
71.3
23.7
328.95
331.75
g/l
7.87
418
3847
6
13
4.65
2.27
1.5
1.3
—
—
—
0
0
6
13
4.65
2.27
7.7
5.3
—
—
—
0
0
23
121
1.94
2.24
3.4
1.2
4.14
3.87
mmol/l
0.18
23
114
5
9
5.59
2.22
18.0
7.3
4.34
6.06
mmol/l
—
5
9
10
35
2.89
2.22
5.7
3.1
0.90
0.86
index
—
10
35
426
4523
0.74
2.21
4.5
4.6
1.45
1.28
mmol/l
4.33
393
4113
223
1905
1.29
2.19
17.6
5.9
16.59
2.44
ug/l
4.53
213
1707
25
139
1.84
2.08
1.3
1.2
—
—
—
0
0
23
125
1.88
2.05
2.1
1.8
5.59
4.10
iu/l
—
10
46
14
63
2.25
2.02
1.3
1.4
0.22
0.20
nmol/l
0.29
14
45
8
26
3.11
2.02
2.3
1.6
51.63
73.90
mg/l
—
8
20
15
70
2.18
2.00
1.1
1.3
4.71
4.62
u/ml
—
7
26
12
51
2.38
1.96
1.0
1.2
—
—
—
0
0
183
1546
1.28
1.92
6.7
4.3
0.02
0.00
estimate
0.49
90
511
95
738
1.35
1.83
1.3
1.2
—
—
—
0
0
9
35
2.60
1.81
1.1
1.0
—
—
—
0
0
7
24
2.94
1.72
1.6
1.8
1.16
0.89
nmol/l
—
7
17
5
13
3.87
1.72
1.4
1.6
—
—
—
0
0
11
48
2.32
1.71
2.1
3.0
7.21
8.17
mmol/l
0.74
11
48
41
278
1.51
1.67
3.4
2.4
—
—
—
0
0
14
69
2.06
1.66
1.1
1.1
—
—
—
0
0
10
41
2.47
1.65
1.5
1.2
—
—
—
0
0
14
70
2.03
1.60
1.1
1.1
—
—
—
0
0
14
70
2.03
1.60
1.3
1.4
0.57
27.18
nmol/l
0.49
14
64
11
50
2.22
1.58
1.1
1.0
—
—
—
0
0
5
15
3.35
1.52
2.0
1.8
—
—
—
0
0
7
27
2.61
1.52
1.4
1.4
77.43
76.22
umol/l
—
7
27
14
72
1.97
1.50
1.1
1.2
—
—
—
0
0
9
38
2.39
1.46
1.3
1.2
—
—
—
0
0
9
38
2.39
1.46
3.1
1.5
95.51
77.46
ng/l
—
9
38
6
22
2.75
1.44
1.0
1.2
—
—
—
0
0
104
848
1.28
1.43
1.3
1.3
16.48
14.10
u/ml
0.12
31
309
22
134
1.67
1.41
4.8
4.7
—
—
—
0
0
9
40
2.27
1.40
1.3
1.2
—
—
—
0
0
5
122
0.40
1.38
1.8
2.0
164.20
228.67
pmol/l
—
5
111
10
47
2.15
1.34
2.7
3.2
14.08
16.71
%
—
10
47
503
4872
1.39
1.34
44.0
16.0
—
—
—
0
0
9
43
2.11
1.31
1.4
1.2
—
—
—
0
0
12
62
1.96
1.28
5.3
2.1
-1.46
0.66
mmol/l
0.74
12
62
143
1225
1.23
1.28
6.2
4.4
1.01
1.02
kg/l
3.27
114
820
11
203
0.53
1.27
1.1
1.1
—
—
—
0
0
35
246
1.45
1.24
2.1
2.9
—
—
—
0
0
7
141
0.49
1.22
3.3
1.6
—
—
—
0
0
7
144
0.48
1.22
2.1
2.0
41.29
42.20
nmol/l
—
7
133
21
321
0.64
1.20
1.3
1.3
—
—
—
0
0
15
86
1.77
1.20
1.3
2.7
—
—
—
0
0
35
256
1.39
1.03
1.6
3.7
12.73
5309.14
u/ml
0.76
30
219
11
60
1.85
1.03
1.4
1.4
—
—
nmol/l
—
0
0
449
4640
0.82
0.98
6.9
7.1
40.06
39.79
mmol/mol
0.29
430
4320
5
23
2.18
0.98
1.2
1.1
—
—
—
0
0
21
143
1.49
0.91
1.1
1.1
—
—
—
0
0
129
1136
1.18
0.86
4.6
3.4
1.59
0.75
ug/l
2.00
104
771
39
499
0.76
0.86
1.3
1.5
—
—
—
0
0
177
1947
0.87
0.84
4.8
4.2
15.87
7.86
mg/mmol
0.95
119
1203
21
295
0.70
0.83
1.7
1.2
54.67
131.61
u/ml
—
6
109
28
206
1.38
0.83
1.7
1.4
0.36
0.32
mg/l
0.14
15
99
35
268
1.33
0.81
3.0
2.1
—
—
—
0
0
19
132
1.46
0.77
1.4
1.4
—
—
—
0
0
5
24
2.09
0.74
1.2
1.2
112.60
179.65
mmol/24h
—
5
24
5
25
2.01
0.73
1.0
1.0
815.00
1429.16
miu/ml
—
5
25
176
1912
0.88
0.68
4.5
3.5
60.59
46.52
mg/l
0.54
127
1229
5
95
0.52
0.67
2.2
1.5
—
—
—
0
0
5
29
1.73
0.64
1.0
1.3
179.40
145.36
nmol/l
—
5
29
11
71
1.56
0.62
1.5
1.4
48.25
72.92
mu/l
0.24
11
66
0
20
0.00
0.60
0.0
1.2
—
0.25
—
0
11
33
266
1.26
0.56
5.2
3.7
1.02
1.02
ratio
0.78
33
253
9
136
0.66
0.52
1.2
1.1
—
—
—
0
0
7
110
0.63
0.48
1.0
1.2
1.71
1.56
g/l
—
7
110
103
935
1.13
0.48
1.5
1.3
45.29
37.85
iu/ml
0.17
29
296
49
425
1.17
0.43
3.5
2.6
6.06
6.09
ph
0.10
36
300
8
57
1.41
0.42
1.3
1.4
—
—
—
0
0
8
57
1.41
0.42
1.4
1.3
—
—
—
0
0
8
58
1.38
0.41
3.5
2.4
—
—
—
0
0
5
33
1.52
0.41
1.0
1.0
—
—
—
0
0
186
1966
0.92
0.41
4.2
3.4
6.28
7.42
mmol/l
4.25
168
1641
12
160
0.74
0.40
17.6
11.8
—
—
—
0
0
10
71
1.42
0.39
1.3
1.3
—
—
—
0
0
8
116
0.69
0.37
1.4
1.2
0.71
0.91
g/l
—
8
116
6
46
1.31
0.33
1.7
2.5
—
—
—
0
0
11
142
0.77
0.31
3.9
2.4
164.07
79.96
ug/min
—
6
81
387
3799
1.06
0.25
5.5
4.2
15.00
14.97
pmol/l
0.08
366
3438
0
11
0.00
0.21
0.0
2.5
—
15.46
—
0
11
6
52
1.16
0.19
2.0
2.3
—
—
—
0
0
67
630
1.07
0.18
1.7
1.3
—
—
—
0
0
7
62
1.13
0.17
1.3
1.1
—
—
—
0
0
8
68
1.18
0.16
1.1
1.4
550.25
253.93
pmol/l
—
8
59
44
460
0.95
0.08
2.1
1.6
—
—
—
0
0
447
4484
0.98
0.03
6.4
5.4
1.93
1.97
mu/l
0.22
425
4090
472
4711
1.01
0.01
5.9
5.7
6.01
6.04
mmol/l
0.16
440
4298
0
6
0.00
0.00
0.0
1.2
—
39.23
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
60.44
—
0
9
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
32
320
1.00
-0.00
1.6
1.4
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
17.97
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint OSTEON_DRUGS and mortality.

Females

Parameter HR [95% CI] p-value
OSTEON_DRUGS 6.288 [4.04, 9.8] < 0.001
Birth year 0.993 [0.98, 1.0] 0.139

During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 709 females with OSTEON_DRUGS died.

Males

Parameter HR [95% CI] p-value
OSTEON_DRUGS 7.082 [4.47, 11.23] < 0.001
Birth year 0.985 [0.97, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 330 out of 697 males with OSTEON_DRUGS died.

Mortality risk

Mortality risk for people of age

years, who have OSTEON_DRUGS.

N-year risk Females Males
1 0.545% 1.567%
5 3.374% 8.081%
10 8.458% 18.232%
15 15.072% 31.532%
20 25.297% 48.531%

Relationships between endpoints

Index endpoint: OSTEON_DRUGS – Osteonecrosis due to drugs

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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