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Henoch-Schönlein purpura nephritis (HSPN)

Endpoint Browser PheWeb

N14_HENOCHSCHONLEIN_NEPHRITIS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

151

4. Check minimum number of events

None

151

5. Include endpoints

None

151

6. Filter based on genotype QC (FinnGen only)

137

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF7

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1118 469 646
Only index persons 1031 442 589
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 22.53 20.27 24.01
Only index persons 23.01 21.65 24.04

-FinnGen-

Key figures

All Female Male
Number of individuals 137 70 67
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 44.47 34.99 54.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
142
Matched controls
1420
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
189.1
136
*
D69.0
ICD-10 Finland
Allergic purpura
467.6
99.7
89
5
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
1201.7
74.2
66
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
54.8
49
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
173.5
47.1
47
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
13.3
41.7
47
51
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
32.6
30
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.2
31.0
54
99
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
+∞
28.0
26
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
10.4
26.4
33
40
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
43.5
25.5
31
9
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
52.6
22.3
26
6
C03CA01
ATC
furosemide; systemic
5.5
22.1
64
185
N18.8
ICD-10 Finland
Other chronic renal failure
36.6
21.5
27
9
L04AA06
ATC
mycophenolic acid; systemic
50.0
21.3
25
6
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
50.0
21.3
25
6
205
Kela drug reimbursment
Chronic hypertension
5.4
20.6
56
152
KA1AE
NOMESCO Finland
Kidney ultrasound examination
31.5
20.0
26
10
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.4
19.8
26
33
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.1
19.3
98
432
Z94.0
ICD-10 Finland
Kidney transplant status
81.4
19.3
21
*
TK800
NOMESCO Finland
Hemodialysis
29.9
19.0
25
10
H02AB06
ATC
prednisolone; systemic
5.1
18.7
101
463
A11CC03
ATC
alfacalcidol; systemic
38.8
18.6
23
7
127
Kela drug reimbursment
Transplant complication
48.9
17.8
21
5
A12AA04
ATC
calcium carbonate; oral
48.9
17.8
21
5
R31
ICD-10 Finland
Unspecified haematuria
6.5
17.5
33
63
H02AB04
ATC
methylprednisolone; systemic
5.6
16.6
38
87
Z49.1
ICD-10 Finland
Extracorporeal dialysis
38.4
16.2
20
6
B03XA02
ATC
darbepoetin alfa; parenteral
68.1
16.2
18
*
M10.9
ICD-10 Finland
Gout, unspecified
7.4
16.1
26
42
M36.4*D69.0
ICD-10 Finland
Arthropathy in Henoch(-Schönlein) purpura
+∞
15.9
15
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
13.6
15.6
27
24
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.7
14.3
41
113
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.8
13.8
64
250
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
76.9
12.8
14
*
L04AA01
ATC
[U] ciclosporin
76.9
12.8
14
*
L04AD02
ATC
tacrolimus; systemic
41.5
12.5
15
*
L04AD01
ATC
ciclosporin; systemic
41.5
12.5
15
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
51.4
12.1
14
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
51.4
12.1
14
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
71.0
11.8
13
*
137
Kela drug reimbursment
Uraemia requiring dialysis
71.0
11.8
13
*
V03AE02
ATC
sevelamer; oral
130.1
11.6
12
*
C09AA02
ATC
enalapril; systemic
3.9
11.6
43
142
C09CA01
ATC
losartan; oral
3.5
11.3
53
204
M04AA01
ATC
allopurinol; systemic
4.6
11.2
31
82
V03AE01
ATC
polystyrene sulfonate; oral
30.8
11.0
14
5
L95.8
ICD-10 Finland
Other vasculitis limited to skin
65.0
10.8
12
*
L04AX01
ATC
azathioprine; systemic
10.9
10.7
20
21
B05DA
ATC
Isotonic solutions
118.4
10.6
11
*
Z49.2
ICD-10 Finland
Other dialysis
118.4
10.6
11
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
35.5
10.5
13
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
43.4
10.1
12
*
A10BK01
ATC
dapagliflozin; oral
5.1
9.7
22
49
C08CA02
ATC
felodipine; oral
5.3
9.7
21
45
B03XA01
ATC
erythropoietin; parenteral
106.9
9.5
10
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
106.9
9.5
10
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.9
8.9
30
91
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.2
8.9
47
192
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
53.4
8.8
10
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
8.8
50
213
B05DB
ATC
Hypertonic solutions
95.5
8.5
9
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
95.5
8.5
9
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
95.5
8.5
9
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
8.4
8
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
18.5
8.2
12
7
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.4
8.2
19
29
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
35.6
8.2
10
*
H05BX01
ATC
cinacalcet; oral
35.6
8.2
10
*
C08CA01
ATC
amlodipine; oral
2.8
8.2
61
299
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
8.2
28
86
R50.9
ICD-10 Finland
Fever, unspecified
3.2
7.9
38
145
TK820
NOMESCO Finland
Peritoneal dialysis
47.6
7.8
9
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
8.4
7.6
16
21
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
7.3
7
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
31.8
7.2
9
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.2
7.2
21
57
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.9
6.9
22
64
UJF32
NOMESCO Finland
Coloscopy
2.8
6.7
41
179
SPAT1262
SPAT
Handing over of treatment supplies
3.2
6.6
30
110
C02AC05
ATC
moxonidine; oral
8.0
6.6
14
19
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.8
6.5
13
16
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
73.0
6.5
7
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.9
6.4
15
24
C07AB02
ATC
metoprolol; systemic
3.0
6.2
32
127
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.7
6.1
41
187

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
92
160
14.49
59.80
19.4
6.5
1.20
1.07
mmol/l
2.60
87
143
47
46
14.78
44.73
1.6
1.3
—
—
—
0
0
110
343
10.79
39.35
10.3
3.3
200.51
79.04
mg/l
2.31
103
224
111
354
10.78
38.67
12.8
3.7
33.70
11.60
mg/mmol
2.40
106
228
39
36
14.56
38.15
9.2
3.0
461.21
390.26
mg/l
0.19
29
19
101
400
6.28
24.43
11.4
3.1
56.29
189.50
e6/l
0.40
89
313
53
121
6.39
23.98
11.2
3.9
0.83
1.58
mmol/l
0.91
46
101
30
10
37.52
23.94
3.0
5.4
934.27
391.40
mg
—
30
10
53
123
6.28
23.52
11.4
4.1
7.36
7.38
ph
0.95
42
78
62
173
5.59
22.30
1.6
1.4
667.69
405.00
titre
0.30
13
40
35
58
7.68
21.47
1.3
2.6
—
—
—
0
0
103
454
5.62
20.80
13.5
3.6
69.33
39.58
e6/l
0.22
89
318
87
344
4.95
19.92
11.0
2.8
0.10
0.35
e6/l
2.66
72
256
31
50
7.65
19.38
1.6
1.2
—
—
—
0
0
57
171
4.90
18.32
2.9
2.0
30.59
28.99
s
0.41
57
166
43
105
5.44
17.59
14.0
10.8
—
—
—
0
0
110
561
5.26
17.19
28.3
8.2
1.21
1.21
mmol/l
0.14
94
490
88
408
4.04
14.97
8.9
5.5
—
—
—
0
0
53
179
4.13
14.12
8.0
2.6
3.72
2.00
e6/l
0.40
36
86
78
344
3.81
14.06
18.3
4.3
7.39
7.39
ph
0.18
70
241
21
13
18.70
13.96
1.2
2.0
—
—
—
0
0
36
93
4.85
13.53
2.4
2.4
74.28
76.49
e9/l
0.13
29
71
27
57
5.61
12.74
1.3
1.6
2.62
5.34
iu/ml
—
6
14
99
537
3.79
12.50
8.4
3.2
6.18
6.22
ph
0.13
62
303
27
60
5.32
12.01
7.5
3.0
0.71
0.61
%
0.41
27
60
111
659
4.13
12.00
10.3
3.6
0.00
0.00
estimate
-0.00
29
136
110
652
4.05
11.85
10.8
5.8
0.04
0.04
e9/l
0.17
105
568
111
666
4.05
11.65
10.4
3.6
45.77
0.00
estimate
0.49
30
133
111
670
4.01
11.45
10.6
3.6
0.00
0.00
estimate
-0.00
29
126
70
320
3.34
11.35
7.4
4.4
—
—
—
0
0
25
55
5.30
11.22
11.0
3.4
—
—
—
0
0
110
674
3.80
10.77
11.1
5.9
1.93
1.97
e9/l
0.17
105
608
47
176
3.50
10.38
3.1
2.6
—
—
—
0
0
109
673
3.67
10.34
11.2
6.2
0.19
0.19
e9/l
0.07
104
597
25
60
4.84
10.12
7.9
3.0
1.12
1.26
%
0.45
25
60
30
89
4.01
9.24
8.7
8.8
23.86
25.12
mmol/l
1.03
30
89
61
291
2.92
8.71
3.2
1.8
—
—
—
0
0
12
6
21.66
8.63
1.2
7.5
—
—
—
0
0
15
14
11.82
8.52
12.5
3.6
13.02
11.26
pmol/l
0.12
15
14
86
501
2.82
8.28
16.8
10.5
1.34
1.17
inr
1.49
79
411
110
732
3.23
8.23
11.8
9.5
5.32
4.04
e9/l
6.42
102
639
7
0
+∞
7.35
1.0
0.0
—
—
—
0
0
104
694
2.86
7.30
9.4
6.2
6.44
6.57
mmol/l
0.32
99
650
96
623
2.67
6.99
6.4
2.9
138.87
107.05
ug/l
1.02
91
588
123
910
3.63
6.98
14.7
8.1
81.47
81.44
u/l
0.00
118
869
67
369
2.54
6.87
9.9
3.8
0.00
0.01
estimate
0.50
23
121
36
145
2.99
6.79
1.7
1.5
—
—
—
0
0
60
320
2.52
6.51
4.8
2.6
—
—
—
0
0
13
16
8.82
6.49
1.3
1.4
—
—
—
0
0
38
162
2.84
6.44
11.2
8.7
102.71
104.67
mmol/l
1.45
38
162
13
17
8.29
6.28
1.5
3.4
1.23
1.35
ratio
—
8
8
17
33
5.70
6.25
3.1
1.2
—
—
—
0
0
82
511
2.43
6.25
10.3
3.5
0.00
0.01
estimate
0.50
27
117
60
326
2.46
6.20
1.6
1.3
3.32
2.40
g/l
4.16
47
195
17
44
4.25
6.19
2.4
2.2
281.65
403.78
ug/l
0.31
17
39
10
8
13.32
6.18
1.4
6.8
—
—
—
0
0
46
223
2.57
6.03
3.6
1.7
—
—
—
0
0
28
104
3.11
6.03
3.4
1.9
0.00
0.00
estimate
—
8
24
17
36
5.22
5.84
1.8
1.2
158.33
194.56
u/ml
0.64
12
18
93
639
2.32
5.33
5.8
6.7
11.03
10.97
umol/l
0.01
87
617
32
137
2.72
5.32
2.8
1.9
—
—
—
0
0
83
547
2.25
5.22
20.7
10.8
0.00
0.00
e9/l
0.50
68
434
53
292
2.30
5.14
6.7
4.0
90.87
93.18
%
0.22
53
287
62
370
2.20
4.91
8.8
3.0
0.16
0.00
estimate
0.48
19
107
61
362
2.20
4.90
3.5
2.4
—
—
—
0
0
12
22
5.85
4.72
8.7
2.4
—
—
—
0
0
11
18
6.52
4.70
1.1
1.3
—
—
—
0
0
11
18
6.52
4.70
5.8
2.8
11.52
13.33
%
0.74
11
18
29
126
2.64
4.65
7.7
13.9
-1.25
0.87
mmol/l
1.09
21
100
29
129
2.57
4.43
7.7
13.5
7.39
7.42
ph
0.80
20
77
11
20
5.87
4.38
2.2
2.6
—
—
—
0
0
29
130
2.55
4.36
7.7
13.3
4.82
5.08
kpa
0.67
29
122
29
130
2.55
4.36
7.6
13.3
12.00
11.99
kpa
0.00
29
124
16
52
3.34
4.23
5.3
4.7
36.80
36.99
°c
0.45
16
52
53
312
2.11
4.23
3.5
2.1
2.53
2.69
mg/l
0.28
46
271
19
69
3.02
4.21
1.8
1.3
—
—
—
0
0
21
81
2.87
4.20
18.4
3.9
1.21
1.22
mmol/l
0.28
21
69
7
7
10.43
4.05
1.0
1.1
—
—
—
0
0
19
71
2.93
4.01
3.9
11.3
—
—
—
0
0
62
397
2.00
3.88
3.4
2.4
—
—
—
0
0
13
34
4.10
3.80
9.6
2.8
7.39
7.42
ph
1.00
13
34
24
105
2.55
3.78
2.2
2.8
0.19
0.23
g/l
1.53
24
98
13
35
3.98
3.70
3.2
2.2
—
—
—
0
0
30
152
2.23
3.42
1.0
1.2
—
—
—
0
0
10
23
4.59
3.38
1.1
1.0
—
—
—
0
0
6
7
8.88
3.29
1.0
1.0
2457.33
1879.86
miu/ml
—
6
7
136
1225
3.61
3.27
39.3
14.9
22.47
24.44
mg/l
0.37
130
986
9
21
4.50
3.05
1.0
1.4
—
—
—
0
0
9
21
4.50
3.05
1.0
1.4
—
—
—
0
0
9
21
4.50
3.05
1.0
1.4
—
—
—
0
0
9
21
4.50
3.05
1.0
1.4
—
—
—
0
0
10
26
4.06
3.04
5.8
2.9
55.00
58.20
%
—
10
26
21
96
2.39
3.01
7.0
4.6
0.13
0.17
%
—
8
30
14
52
2.88
2.99
1.6
1.7
24.86
20.09
s
0.62
14
46
67
470
1.81
2.98
2.5
2.0
97.63
93.33
pmol/l
0.29
39
257
22
104
2.32
2.93
6.7
4.5
0.50
0.78
%
—
8
39
9
23
4.10
2.82
8.9
2.3
5.19
5.00
kpa
—
9
23
46
293
1.84
2.76
9.2
5.0
—
—
—
0
0
20
95
2.29
2.64
11.3
3.6
—
—
—
0
0
7
15
4.85
2.63
7.6
2.9
4.33
3.99
e9/l
—
7
15
76
568
1.73
2.61
3.6
2.9
—
—
estimate
—
0
0
5
7
7.35
2.57
1.2
2.1
16.20
12.86
%
—
5
7
137
1263
3.40
2.46
36.9
12.5
—
—
—
0
0
29
165
1.95
2.43
2.4
1.6
1263.43
1211.22
nmol/l
0.11
23
127
6
12
5.17
2.42
1.2
1.0
—
—
—
0
0
8
23
3.62
2.30
9.9
2.3
9.51
8.82
kpa
—
8
23
20
101
2.14
2.29
7.1
4.9
0.00
0.30
%
—
7
30
5
9
5.71
2.23
1.4
1.2
658.34
110.78
iu/ml
—
5
9
38
243
1.77
2.21
1.3
1.3
26.93
26.65
iu/ml
—
7
68
6
162
0.34
2.19
1.2
1.4
—
—
—
0
0
56
400
1.66
2.18
10.5
5.8
—
—
—
0
0
46
313
1.69
2.15
10.0
3.6
1.02
1.02
kg/l
0.10
39
203
5
10
5.14
2.09
1.0
2.0
—
—
nmol/l
—
0
0
11
44
2.63
2.06
1.5
1.4
—
—
—
0
0
58
427
1.61
1.97
4.4
3.8
38.81
34.59
ng/l
0.13
48
265
19
100
2.04
1.97
7.2
4.4
0.17
0.47
%
—
6
35
16
79
2.16
1.94
1.4
1.2
—
—
—
0
0
6
17
3.64
1.86
1.0
1.1
—
—
—
0
0
6
17
3.64
1.86
1.2
1.5
31.30
46.53
ng/l
—
6
17
122
1086
1.88
1.85
10.8
5.7
39.57
38.61
mmol/mol
0.50
113
1028
6
19
3.25
1.68
1.8
2.1
—
—
—
0
0
7
25
2.89
1.67
5.3
4.4
—
—
—
0
0
7
25
2.89
1.67
1.0
1.2
—
—
—
0
0
20
115
1.86
1.63
2.6
3.2
48.00
29.42
u/l
1.23
20
98
121
1086
1.77
1.63
6.6
4.0
1.46
1.28
mmol/l
1.11
115
1012
16
87
1.95
1.53
1.7
1.3
—
—
—
0
0
126
1153
1.82
1.46
8.0
5.1
2.65
2.70
mmol/l
0.30
121
1086
32
218
1.60
1.45
1.2
1.2
0.98
7.07
u/ml
—
5
77
9
42
2.22
1.36
1.4
1.2
—
—
—
0
0
122
1119
1.64
1.23
7.6
4.5
5.87
5.84
mmol/l
0.09
114
1036
17
102
1.76
1.23
3.8
2.0
6.18
6.16
ph
0.03
11
65
47
364
1.44
1.17
1.3
1.4
0.81
1.16
u/ml
0.57
17
102
21
136
1.64
1.17
1.8
1.6
—
—
—
0
0
123
1138
1.60
1.10
7.7
4.6
1.33
1.42
mmol/l
1.86
117
1069
36
268
1.46
1.09
2.0
1.8
0.92
1.55
mg/l
0.83
30
218
123
1140
1.59
1.07
7.8
4.7
4.54
4.56
mmol/l
0.07
117
1078
30
219
1.47
1.00
2.7
2.1
—
—
—
0
0
6
28
2.19
0.92
1.0
1.2
—
—
—
0
0
8
43
1.91
0.89
2.6
2.1
—
—
—
0
0
26
192
1.43
0.83
1.8
2.4
103.52
84.75
ug/g
0.33
21
150
47
384
1.33
0.83
1.7
1.6
—
—
—
0
0
20
140
1.50
0.82
1.3
1.2
—
—
—
0
0
30
229
1.39
0.80
4.2
3.1
543.27
412.52
ng/l
0.09
22
155
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
120
1125
1.43
0.78
5.2
5.0
1.90
1.82
mu/l
0.55
115
1038
55
467
1.29
0.72
2.6
1.9
1.50
1.41
mmol/l
0.22
47
414
10
61
1.69
0.70
1.5
1.4
9.80
7.72
u/l
—
5
46
5
29
1.75
0.64
1.2
1.4
2.20
29.22
e6/l
—
5
23
5
29
1.75
0.64
9.4
3.4
1.06
1.47
mmol/l
—
5
29
10
63
1.63
0.63
1.0
1.1
—
—
—
0
0
5
30
1.69
0.62
1.4
1.4
1.40
263.48
e6/l
—
5
25
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
13
91
1.47
0.55
2.2
2.6
—
11.99
—
0
10
27
218
1.29
0.51
1.4
1.6
—
—
—
0
0
7
51
1.39
0.44
6.6
2.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
51
455
1.19
0.40
2.3
1.9
—
—
—
0
0
16
127
1.29
0.35
2.1
2.0
—
—
—
0
0
17
142
1.22
0.26
1.4
1.5
—
—
—
0
0
5
39
1.29
0.23
17.6
14.8
—
—
—
0
0
0
11
0.00
0.21
0.0
10.4
—
908.55
—
0
11
0
11
0.00
0.21
0.0
12.7
—
1422.82
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
15
130
1.17
0.16
1.3
1.4
—
—
—
0
0
6
76
0.78
0.16
1.2
1.2
—
—
—
0
0
7
87
0.79
0.15
1.0
1.5
—
—
—
0
0
8
99
0.80
0.14
1.1
1.4
—
—
—
0
0
9
105
0.85
0.13
1.1
1.4
—
—
—
0
0
13
146
0.88
0.11
1.2
1.2
—
—
—
0
0
6
53
1.14
0.09
1.2
1.1
1.24
1.53
g/l
—
6
53
6
54
1.12
0.09
1.2
1.1
0.92
0.91
g/l
—
6
54
6
70
0.85
0.08
1.0
1.0
—
—
—
0
0
48
487
0.98
0.01
4.1
2.8
—
—
—
0
0
10
104
0.96
0.00
1.1
1.4
—
—
—
0
0
96
962
0.99
0.00
4.5
4.1
14.93
14.60
pmol/l
0.75
86
884
10
103
0.97
0.00
1.1
1.4
—
—
—
0
0
10
103
0.97
0.00
1.1
1.4
—
—
—
0
0
24
235
1.03
0.00
2.3
3.0
0.65
0.78
ug/l
0.37
16
143
5
54
0.92
-0.00
3.0
1.7
38.20
39.35
nmol/l
—
5
48
0
5
0.00
-0.00
0.0
6.6
—
2.28
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
69.24
—
0
8
0
5
0.00
-0.00
0.0
2.2
—
159.20
—
0
5
5
54
0.92
-0.00
3.8
3.9
32.20
1421.68
u/ml
—
5
44
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
0.23
—
0
5
7
69
1.02
-0.00
1.9
2.3
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.1
—
0.64
—
0
9
0
5
0.00
-0.00
0.0
11.8
—
7.85
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
0.38
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
0.00
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.4
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint N14_HENOCHSCHONLEIN_NEPHRITIS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
N14_HENOCHSCHONLEIN_NEPHRITIS 2.718 [1.97, 3.75] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 588 males with N14_HENOCHSCHONLEIN_NEPHRITIS died.

Mortality risk

Mortality risk for people of age

years, who have N14_HENOCHSCHONLEIN_NEPHRITIS.

N-year risk Females Males
1 No data 0.508%
5 No data 2.64%
10 No data 6.883%
15 No data 12.352%
20 No data 20.208%

Relationships between endpoints

↥

Index endpoint: N14_HENOCHSCHONLEIN_NEPHRITIS – Henoch-Schönlein purpura nephritis (HSPN)

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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