≡ Risteys
R14

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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Use of riluzole

Endpoint Browser

MNMED_RILUZOLE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC — N07XX02

1 out of 7 registries used, show all original rules.

164

4. Check minimum number of events

Min. number of events 3
164

5. Include endpoints

None

164

6. Filter based on genotype QC (FinnGen only)

145

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 145 64 81
Unadjusted period prevalence (%) 0.03 0.02 0.04
Median age at first event (years) 65.62 66.37 65.03

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
151
Matched controls
1510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N07XX02
ATC
riluzole; oral
+∞
218.3
151
*
G12.2
ICD-10 Finland
Motor neuron disease
6269.6
192.5
144
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
108.7
126.2
67
11
J96.1
ICD-10 Finland
Chronic respiratory failure
61.2
93.8
55
14
Z51.5
ICD-10 Finland
Palliative care
14.7
60.3
72
88
N99
ICPC
Neurological disease other
163.8
60.1
60
6
R4130
NOMESCO Finland
Speech therapy
22.5
48.8
39
23
JDB10
NOMESCO Finland
Percutaneous gastrostomy
105.5
47.5
50
7
R47.1
ICD-10 Finland
Dysarthria and anarthria
69.3
33.1
37
7
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
9.4
31.6
45
65
R13
ICD-10 Finland
Dysphagia
9.1
30.3
44
65
N28
ICPC
Limited function/disability (N)
64.4
27.4
31
6
WX725
NOMESCO Finland
Noninvasive ventilation
8.6
21.7
31
44
R4120
NOMESCO Finland
Occupational therapy
7.5
19.8
32
52
R4190
NOMESCO Finland
Nutritional therapy
20.8
19.7
29
17
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.3
18.9
48
121
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
8.4
17.5
25
35
TJD20
NOMESCO Finland
Change of gastrostomy tube
101.5
17.0
18
*
A28
ICPC
Limited function/disability NOS
4.3
16.7
61
204
G12.9
ICD-10 Finland
Spinal muscular atrophy, unspecified
+∞
15.9
15
*
TAB00
NOMESCO Finland
Lumbar puncture
6.8
13.0
22
37
N02AA01
ATC
morphine; systemic, rectal
18.4
12.0
18
11
R1250
NOMESCO Finland
Evaluation of functional capability
13.4
11.7
20
17
R5599
NOMESCO Finland
Other rehabilitation service
11.9
11.2
20
19
XG466
NOMESCO Finland
Sleep oxymetry
10.0
10.7
21
24
L28
ICPC
Limited function/disability (L)
3.3
10.0
49
191
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
8.7
9.5
20
26
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
9.3
9.4
19
23
SPAT1229
SPAT
Assessment of need for aid
4.6
9.2
24
60
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.0
9.2
29
84
R1260
NOMESCO Finland
Evaluation of communicative skills
15.3
8.9
14
10
R5140
NOMESCO Finland
Monitoring the use of the aid
3.4
8.2
34
118
GX2D5
NOMESCO Finland
Sleep oximetry
84.0
7.5
8
*
N03AE01
ATC
clonazepam; systemic
4.9
7.4
17
38
R5110, ,
SPAT
3.8
7.2
24
72
I50.9
ICD-10 Finland
Heart failure, unspecified
0.0
6.6
*
186
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
0.2
6.4
7
299
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
13.3
6.2
10
8
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
10.7
6.1
11
11
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
6.9
6.0
14
22

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
77
1240
0.23
18.23
3.1
5.5
1.47
1.44
mmol/l
0.26
64
1138
78
1245
0.23
18.08
3.0
5.6
4.80
4.56
mmol/l
0.94
65
1152
82
1266
0.23
17.63
3.3
6.4
2.82
2.65
mmol/l
0.73
68
1168
79
1210
0.27
13.92
4.2
6.9
36.28
40.22
mmol/mol
8.63
72
1138
77
1194
0.28
13.73
2.7
4.6
1.18
1.31
mmol/l
1.13
64
1090
20
24
9.43
9.93
1.0
1.3
—
—
—
0
0
89
1228
0.33
9.71
3.4
5.6
5.83
6.04
mmol/l
1.68
79
1130
21
29
8.23
9.62
1.0
1.2
1.54
2.78
e6/l
0.62
13
18
21
31
7.69
9.23
1.0
1.3
134.36
231.05
e6/l
0.17
14
21
18
37
5.39
8.61
4.8
2.6
—
—
—
0
0
30
101
3.46
7.59
2.8
9.2
—
—
—
0
0
30
102
3.42
7.48
1.5
2.6
—
—
—
0
0
16
468
0.26
6.62
2.8
3.4
9.95
45.17
mg/l
3.71
11
315
42
186
2.74
6.59
4.0
9.9
6.24
5.10
kpa
2.20
42
178
18
481
0.29
6.24
3.6
4.1
2.70
7.71
mg/mmol
1.59
13
311
41
186
2.65
6.10
4.1
9.9
12.17
12.21
kpa
0.02
41
178
9
6
15.83
5.98
2.0
1.3
17.43
16.35
%
—
9
6
40
717
0.40
5.92
3.0
4.2
0.00
0.00
estimate
-0.00
12
157
42
723
0.42
5.44
3.0
4.2
0.00
10.15
estimate
0.50
12
160
11
15
7.81
5.24
1.0
1.3
—
—
—
0
0
43
727
0.43
5.24
2.9
4.2
0.00
0.00
estimate
-0.00
12
145
19
62
3.36
4.99
5.1
4.0
—
—
—
0
0
24
510
0.37
4.95
2.2
3.6
—
—
—
0
0
38
185
2.41
4.79
4.7
10.1
7.41
7.42
ph
0.20
26
111
21
75
3.09
4.78
3.0
4.6
36.95
36.93
°c
0.11
21
75
35
166
2.44
4.66
4.0
10.5
94.67
95.54
%
0.29
35
161
9
12
7.89
4.42
3.1
2.8
3.72
0.48
mmol/l
—
9
12
31
565
0.43
4.26
2.2
3.9
6.42
6.16
ph
0.69
19
332
30
550
0.43
4.16
2.7
4.2
0.00
0.00
estimate
-0.00
11
131
27
515
0.42
4.13
1.9
2.1
—
—
—
0
0
108
1273
0.47
3.99
10.9
16.5
—
—
—
0
0
8
12
6.97
3.72
1.0
1.1
—
—
—
0
0
34
566
0.48
3.43
3.4
5.7
14.56
2.29
ug/l
0.46
28
510
22
422
0.44
3.24
3.1
4.0
0.00
0.00
estimate
-0.00
11
144
16
348
0.40
3.21
2.3
3.3
0.95
0.84
ug/l
0.13
11
235
11
33
3.51
2.88
7.5
3.0
3.17
2.66
mmol/l
0.27
11
20
39
585
0.55
2.62
2.5
4.4
156.70
41.57
ng/l
0.54
33
446
5
7
7.34
2.57
1.0
1.0
—
—
—
0
0
5
7
7.34
2.57
1.0
1.0
—
—
—
0
0
5
7
7.34
2.57
1.0
1.0
—
—
—
0
0
20
366
0.48
2.50
2.5
3.5
—
0.00
—
0
9
17
328
0.46
2.45
2.8
3.8
—
0.00
—
0
6
24
407
0.51
2.37
2.7
3.7
0.00
0.01
estimate
—
9
132
110
1245
0.57
2.28
14.2
18.9
31.41
24.56
mg/l
0.99
98
1056
6
157
0.36
2.04
1.3
1.3
—
—
—
0
0
0
47
0.00
1.74
0.0
1.2
—
0.92
—
0
47
23
136
1.82
1.71
2.7
2.6
0.24
0.21
g/l
1.81
23
126
21
121
1.85
1.69
3.8
8.8
—
—
—
0
0
9
181
0.47
1.64
1.1
1.3
—
—
—
0
0
0
42
0.00
1.55
0.0
1.1
—
0.78
—
0
9
0
42
0.00
1.55
0.0
1.1
—
—
—
0
0
0
44
0.00
1.54
0.0
1.4
—
300.49
—
0
25
0
45
0.00
1.52
0.0
1.2
—
1.57
—
0
45
12
222
0.50
1.50
1.2
2.2
—
—
—
0
0
39
524
0.66
1.45
3.8
4.3
50.79
71.63
e6/l
0.25
27
382
18
104
1.83
1.44
5.8
11.8
28.55
24.76
mmol/l
2.49
18
98
90
1031
0.69
1.42
19.4
23.1
13.60
13.77
%
0.99
90
1023
33
457
0.64
1.41
1.5
3.0
52.63
63.22
u/l
0.51
27
430
7
146
0.45
1.41
1.1
2.3
420.43
373.96
nmol/l
—
7
132
7
149
0.44
1.41
3.7
2.0
301.57
134.16
ug/g
—
7
128
0
39
0.00
1.36
0.0
1.6
—
—
—
0
0
24
352
0.62
1.32
1.1
2.1
2.09
3.01
mg/l
1.15
19
307
6
126
0.45
1.23
1.3
1.3
—
—
—
0
0
0
33
0.00
1.17
0.0
1.1
—
6.19
—
0
24
0
35
0.00
1.17
0.0
4.7
—
24.69
—
0
27
0
36
0.00
1.15
0.0
1.2
—
—
—
0
0
0
36
0.00
1.15
0.0
1.2
—
—
—
0
0
11
191
0.54
1.14
4.4
3.4
2.38
1.74
%
1.45
11
171
6
124
0.46
1.11
1.8
1.3
—
—
—
0
0
50
613
0.72
1.05
2.1
3.1
—
—
estimate
—
0
0
37
476
0.71
1.04
3.4
3.6
125.13
172.13
e6/l
0.10
26
365
33
430
0.70
0.99
4.0
6.9
—
—
—
0
0
0
31
0.00
0.97
0.0
1.3
—
—
—
0
0
5
103
0.47
0.93
1.4
3.8
66.40
74.60
ng/l
—
5
89
14
211
0.63
0.86
1.4
2.7
23.79
22.63
%
0.12
14
197
25
183
1.44
0.83
1.2
1.7
—
—
—
0
0
20
140
1.49
0.82
1.5
4.0
7.37
7.38
ph
—
9
89
0
25
0.00
0.80
0.0
1.0
—
—
—
0
0
0
26
0.00
0.79
0.0
1.1
—
—
—
0
0
13
194
0.64
0.77
1.0
1.3
—
—
—
0
0
25
186
1.41
0.76
1.3
1.3
246.67
493.91
titre
—
6
46
11
166
0.64
0.69
1.3
1.4
—
—
—
0
0
5
95
0.51
0.69
1.2
1.5
—
—
—
0
0
32
396
0.76
0.68
3.5
3.5
—
—
—
0
0
11
165
0.64
0.67
1.4
1.7
—
—
—
0
0
7
44
1.62
0.66
6.3
17.7
0.92
1.18
mmol/l
—
7
37
33
405
0.76
0.66
3.2
3.4
1.17
0.54
e6/l
0.62
23
297
34
274
1.31
0.64
1.5
3.6
0.84
0.82
mmol/l
0.44
27
258
36
434
0.78
0.62
2.0
2.6
—
—
—
0
0
13
184
0.68
0.61
1.2
1.7
—
—
—
0
0
26
203
1.34
0.61
3.9
7.1
102.81
104.14
mmol/l
0.69
26
203
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
4.6
—
—
—
0
0
61
681
0.83
0.51
9.7
14.4
1.24
1.27
inr
0.15
52
567
28
339
0.79
0.50
1.2
1.4
—
—
—
0
0
21
260
0.78
0.45
3.1
4.1
144.95
259.15
ng/l
0.37
21
216
5
33
1.53
0.41
1.2
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
5.78
—
0
9
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
3.4
—
44.75
—
0
8
0
15
0.00
0.41
0.0
1.1
—
1.13
—
0
8
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
2.5
—
—
—
0
0
5
34
1.49
0.40
2.6
2.5
53.20
59.36
%
—
5
34
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
53
587
0.85
0.39
1.9
2.2
88.10
96.02
pmol/l
0.78
26
296
8
114
0.69
0.38
5.6
3.6
—
—
—
0
0
9
122
0.72
0.37
2.3
4.2
7.36
7.34
ph
—
9
85
22
261
0.82
0.33
1.5
1.4
2.24
2.81
g/l
0.64
11
160
6
47
1.29
0.32
5.2
12.8
—
—
—
0
0
59
639
0.87
0.31
4.2
7.4
1.21
1.21
mmol/l
0.03
54
592
8
107
0.73
0.30
1.4
1.4
—
—
—
0
0
12
150
0.78
0.28
1.2
1.5
—
—
—
0
0
8
63
1.28
0.28
1.1
1.6
—
—
—
0
0
38
422
0.87
0.28
4.3
5.3
—
—
—
0
0
5
72
0.68
0.26
1.4
2.3
—
—
—
0
0
38
344
1.14
0.24
4.2
4.4
87.08
87.94
%
0.08
38
337
5
38
1.33
0.23
1.0
1.4
—
—
—
0
0
73
690
1.11
0.23
5.5
6.8
0.03
0.04
e9/l
2.06
61
603
0
11
0.00
0.21
0.0
1.5
—
71100.00
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
3.16
—
0
5
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
32.87
—
0
12
10
80
1.27
0.21
1.7
2.7
0.67
0.62
%
—
10
80
0
13
0.00
0.21
0.0
1.4
—
0.15
—
0
7
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
48
1.26
0.20
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
171.56
—
0
14
0
14
0.00
0.20
0.0
1.1
—
0.36
—
0
8
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
19
217
0.86
0.20
1.4
2.0
31.58
29.17
s
0.61
19
212
7
59
1.20
0.18
1.7
1.9
—
—
—
0
0
72
689
1.09
0.16
5.5
6.7
0.55
0.60
e9/l
1.06
60
602
79
759
1.09
0.16
6.0
11.2
4.11
4.09
e9/l
0.02
67
670
10
83
1.22
0.16
1.7
2.7
0.76
1.23
%
—
10
83
7
86
0.81
0.15
1.0
1.4
—
—
—
0
0
56
588
0.92
0.14
10.1
13.4
0.00
0.00
e9/l
0.77
41
486
33
307
1.10
0.13
4.6
6.0
—
—
—
0
0
48
455
1.08
0.13
5.9
6.6
—
—
—
0
0
73
706
1.07
0.11
5.6
7.0
0.14
0.19
e9/l
2.79
61
629
10
87
1.16
0.09
8.6
14.9
17.43
15.37
%
—
10
82
72
700
1.05
0.09
5.7
6.8
3.27
2.01
e9/l
0.35
59
628
7
66
1.06
0.08
1.6
1.5
—
7.71
—
0
16
30
315
0.94
0.07
1.8
1.7
1.51
1.73
mg/l
0.10
20
253
42
435
0.95
0.06
2.1
4.6
7.40
7.40
ph
0.36
24
313
68
691
0.97
0.03
4.3
8.3
1.23
1.21
mmol/l
2.23
58
602
22
228
0.96
0.02
2.6
3.3
1.19
2.89
e6/l
—
10
117
29
288
1.01
0.00
1.3
1.9
442.92
461.64
pmol/l
0.23
24
242
9
96
0.93
0.00
2.1
2.7
263.78
233.45
ng/l
—
9
80
0
6
0.00
-0.00
0.0
7.2
—
1021.50
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
6.34
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.02
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
213.67
—
0
6
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
6
68
0.88
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
38.2
—
115.60
—
0
5
12
120
1.00
-0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
10944.80
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
131.94
—
0
6
0
6
0.00
-0.00
0.0
6.5
—
37.83
—
0
6
0
9
0.00
-0.00
0.0
2.1
—
0.61
—
0
9
0
5
0.00
-0.00
0.0
1.6
—
10.22
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
7.37
—
0
6
0
5
0.00
-0.00
0.0
4.2
—
—
—
0
0
9
99
0.90
-0.00
1.2
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: MNMED_RILUZOLE – Use of riluzole

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).