macular holes: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2451 |
4. Check minimum number of eventsNone |
2451 |
5. Include endpointsNone |
2451 |
6. Filter based on genotype QC (FinnGen only) |
2254 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 5
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H35
Similar endpoints
↥List of similar endpoints to
Macular hole
based on the number of shared cases.
Similar with more cases:
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10837 | 6967 | 3864 |
| Only index persons | 10716 | 6888 | 3828 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.20 | 0.11 |
| Only index persons | 0.21 | 0.25 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 70.78 | 70.21 | 71.81 |
| Only index persons | 70.75 | 70.16 | 71.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2254 | 1359 | 895 |
| Unadjusted period prevalence (%) | 0.45 | 0.48 | 0.41 |
| Median age at first event (years) | 70.43 | 69.00 | 72.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2302
- Matched controls
- 23020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
82.8
318.3
169
22
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
21.2
308.0
237
124
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
103.3
307.7
207
22
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
189.0
307.7
537
37
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
674.8
307.7
522
10
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
2530.2
307.7
688
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
864.4
307.7
481
7
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
193.5
307.7
524
35
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
13.9
307.7
796
841
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
1181.2
307.7
730
9
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
415.8
307.7
491
15
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.0
307.7
944
2085
H35.37
ICD-10 Finland
Macular holes
4503599627370496.0
307.7
2296
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
5.9
307.7
1551
5987
WX140
NOMESCO Finland
Parabulbar anesthesy
93.3
307.7
1136
238
XCW99
NOMESCO Finland
Other investigative procedure of eye
11.4
307.7
823
1068
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.7
283.8
1520
6701
CKC12
NOMESCO Finland
Photocoagulation of retina
58.4
281.1
158
29
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.7
275.8
383
516
H26.4
ICD-10 Finland
After-cataract
5.5
270.8
660
1572
CJB10
NOMESCO Finland
Laser discission of secondary cataract
5.6
237.2
541
1205
WX142
NOMESCO Finland
Sub-tenon anesthesy
44.4
218.3
130
31
H25.1
ICD-10 Finland
Senile nuclear cataract
3.8
213.2
1267
5661
H33.0
ICD-10 Finland
Retinal detachment with retinal break
1051.3
200.1
193
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
699.7
198.3
193
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
255.4
163.6
166
7
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.5
148.0
680
2477
H33.3
ICD-10 Finland
Retinal breaks without detachment
275.7
128.5
130
5
H26.2
ICD-10 Finland
Complicated cataract
16.1
118.5
102
66
S01ED51
ATC
timolol, combinations; ophthalmic
3.9
111.8
369
1064
WX002
NOMESCO Finland
Sedation and analgesia
2.8
109.0
736
3268
XCH00
NOMESCO Finland
Eye pressure measurement
5.3
108.3
234
483
XCK10
NOMESCO Finland
Photography of fundus of eye
3.9
106.7
358
1042
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
330.4
95.7
96
*
H35.36
ICD-10 Finland
Macular cyst
+∞
95.5
91
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.8
92.6
570
2384
XCD20
NOMESCO Finland
Photoangiography of eye
30.7
82.1
54
18
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
65.9
63
*
ZXA05
NOMESCO Finland
Left side
2.2
64.3
770
4272
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
635.1
63.1
62
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
8.0
59.7
82
106
ZXA00
NOMESCO Finland
Right side
2.1
59.4
815
4740
ZXA10
NOMESCO Finland
Bilateral
2.3
58.4
569
2885
CKD20
NOMESCO Finland
Removal of vitreous body substitute
550.8
54.8
54
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
51.2
49
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
48.7
1216
8535
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
14.0
47.7
44
32
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.7
43.5
263
1062
H53.1
ICD-10 Finland
Subjective visual disturbances
2.8
39.0
217
838
ZXE00
NOMESCO Finland
One hour or less
1.8
38.6
945
6444
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.6
38.3
131
380
S01BC05
ATC
ketorolac; ophthalmic
3.6
37.6
128
370
CKC10
NOMESCO Finland
Local photocoagulation of retina
53.4
35.5
42
8
H34.8
ICD-10 Finland
Other retinal vascular occlusions
43.7
35.0
43
10
CKC20
NOMESCO Finland
Cryopexy of undetached retina
342.1
34.0
34
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.2
33.5
300
1441
H3601, E113,
ICD-10 Finland
+∞
33.4
32
*
H25.0
ICD-10 Finland
Senile incipient cataract
2.4
31.9
232
1018
A98
ICPC
Health maint/preventive medicine
4.2
30.4
2243
20729
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
28.5
899
6424
H35.8
ICD-10 Finland
Other specified retinal disorders
141.7
26.7
28
*
S01EE01
ATC
latanoprost; ophthalmic
2.3
25.9
207
945
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
25.0
24
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
4.0
24.7
70
178
Z2221
NOMESCO Finland
Medical doctor
1.7
24.3
628
4229
H3600, E113,
ICD-10 Finland
+∞
24.0
23
*
S01ED01
ATC
timolol; ophthalmic
3.0
23.2
106
367
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
9.1
23.0
28
31
S01EC01
ATC
acetazolamide; systemic
4.0
22.5
63
159
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
52.5
22.1
26
5
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.8
21.9
113
418
Z3231
NOMESCO Finland
Registered nurse
1.6
21.6
647
4495
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
4.8
21.5
48
101
S01EA03
ATC
apraclonidine; ophthalmic
6.7
20.9
33
50
H35.9
ICD-10 Finland
Retinal disorder, unspecified
32.8
20.2
26
8
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
20.1
893
6762
H36.01
ICD-10 Finland
Diabetic maculopathy
58.0
19.9
23
*
CKC60
NOMESCO Finland
Local buckling of sclera using implant
+∞
19.8
19
*
XCW10
NOMESCO Finland
Assessment of vision
4.3
18.8
49
117
S01EA05
ATC
brimonidine; ophthalmic
3.1
18.8
79
261
H35.6
ICD-10 Finland
Retinal haemorrhage
100.9
18.6
20
*
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
7.9
18.3
25
32
114
Kela drug reimbursment
Glaucoma
1.9
18.3
252
1406
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
52.9
18.0
21
*
XCK00
NOMESCO Finland
Perimetry
2.2
17.8
159
759
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
17.7
17
*
S01EC04
ATC
brinzolamide; ophthalmic
2.4
17.5
125
542
H20.1
ICD-10 Finland
Chronic iridocyclitis
6.1
17.3
30
50
F29
ICPC
Eye symptom/complaint other
1.8
17.2
261
1500
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
50.4
17.0
20
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
7.2
17.0
25
35
H26.02
ICD-10 Finland
Presenil cataract
3.1
16.8
72
241
H35.4
ICD-10 Finland
Peripheral retinal degeneration
63.8
16.7
19
*
CKD50
NOMESCO Finland
Endodiathermy of retina
+∞
16.7
16
*
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
35.3
16.7
21
6
H25.8
ICD-10 Finland
Other senile cataract
1.7
16.3
323
2006
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
15.4
16.2
26
17
F05
ICPC
Visual disturbance other
2.6
16.1
91
354
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.0
15.9
34
69
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
19.3
15.5
23
12
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.2
15.3
138
661
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
15.1
1523
13226
H54.7
ICD-10 Finland
Unspecified visual loss
6.5
14.9
24
37
Z71.8
ICD-10 Finland
Other specified counselling
1.5
14.9
724
5503
H36.00
ICD-10 Finland
Diabetic background retinopathy
21.2
14.6
21
10
S01EC54
ATC
brinzolamide, combinations; ophthalmic
3.5
14.6
49
141
H40.0
ICD-10 Finland
Glaucoma suspect
1.8
14.5
212
1202
S01EE05
ATC
tafluprost; ophthalmic
2.3
14.5
116
529
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
150.9
14.5
15
*
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
3.9
14.0
40
103
F43
ICPC
Eye, Other diagnostic procedure
2.9
13.7
64
225
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
6.1
13.4
23
38
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.4
13.4
90
381
S01BC03
ATC
diclofenac; ophthalmic
3.1
13.2
53
171
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
11.6
12.8
23
20
H3603, E113,
ICD-10 Finland
+∞
12.5
12
*
H3600, E103,
ICD-10 Finland
+∞
12.5
12
*
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
2.8
12.4
62
227
H52.1
ICD-10 Finland
Myopia
2.9
12.3
57
200
Z3229
NOMESCO Finland
Other healthcare associate professional
1.8
11.8
188
1094
H26.8
ICD-10 Finland
Other specified cataract
3.9
11.8
34
88
F38
ICPC
Eye, Other laboratory test NEC
2.9
11.7
53
184
H3603, E103,
ICD-10 Finland
+∞
11.5
11
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
11.5
11
*
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
120.6
11.4
12
*
WX144
NOMESCO Finland
Subconjunctival anesthesy
3.6
11.3
37
105
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
2.6
11.2
62
239
H33.5
ICD-10 Finland
Other retinal detachments
9.6
11.2
22
23
S01EE04
ATC
travoprost; ophthalmic
2.7
11.2
60
228
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
4.7
10.7
24
51
H34.2
ICD-10 Finland
Other retinal artery occlusions
55.2
9.6
11
*
H40.11
ICD-10 Finland
Low pressure glaucoma
2.4
9.6
67
289
R42
ICD-10 Finland
Dizziness and giddiness
1.4
9.6
549
4237
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
100.4
9.4
10
*
WX001
NOMESCO Finland
Nonpharmacological sedation or pain relief
17.6
9.4
14
8
H3601, E103,
ICD-10 Finland
+∞
9.4
9
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
9.4
9
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
9.4
9
*
S21
ICPC
Skin texture symptom/complaint
1.5
9.3
361
2601
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
3.7
9.0
28
77
R4110
NOMESCO Finland
Physiotherapy
1.3
8.9
632
5043
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
4.3
8.7
22
52
CA1ME
NOMESCO Finland
Ultrasound oculometry
4.4
8.6
21
48
H57.1
ICD-10 Finland
Ocular pain
2.1
8.5
74
351
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
2.7
8.5
44
165
H35
ICD-10 Finland
Other retinal disorders
20.1
8.5
12
6
CKC15
NOMESCO Finland
Panretinal photocoagulation
20.1
8.5
12
6
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
90.4
8.4
9
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
90.4
8.4
9
*
N02BE01
ATC
paracetamol; systemic, rectal
1.5
8.4
2034
19253
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
8.3
8
*
Z01.7
ICD-10 Finland
Laboratory examination
1.4
8.3
358
2624
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
1.9
8.1
93
489
H33
ICD-10 Finland
Retinal detachments and breaks
17.2
8.1
12
7
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
11.7
8.1
14
12
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
2.3
8.0
61
275
S01EC03
ATC
dorzolamide; ophthalmic
2.8
7.9
38
137
F99
ICPC
Eye/adnexa disease other
3.7
7.9
24
65
S18
ICPC
Laceration/cut
1.3
7.9
1100
9582
H53.8
ICD-10 Finland
Other visual disturbances
2.9
7.8
36
127
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
10.8
7.8
14
13
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.4
7.7
352
2610
S01EE03
ATC
bimatoprost; ophthalmic
2.2
7.6
62
288
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
7.5
1411
12725
E0000UV, ,
ATC
1.3
7.4
860
7299
H01.0
ICD-10 Finland
Blepharitis
1.7
7.4
121
712
H54.6
ICD-10 Finland
Moderate visual impairment, monocular
7.7
7.4
16
21
J01DB01
ATC
cefalexin; oral
1.3
7.3
1753
16279
CKD91, ,
SPAT
+∞
7.3
7
*
1LA05, ,
NOMESCO Finland
+∞
7.3
7
*
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
7.3
7
*
F13
ICPC
Eye sensation abnormal
2.1
7.3
62
293
L17
ICPC
Foot/toe symptom/complaint
1.3
7.2
687
5680
H43.3
ICD-10 Finland
Other vitreous opacities
2.9
7.2
33
116
ZX198
NOMESCO Finland
Other local administration
5.8
7.2
19
33
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.3
7.2
542
4343
CH2X4
NOMESCO Finland
Optical coherence tomography (OCT) of iris and iridocorneal angle
30.1
7.1
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
6.9
671
5558
H44.2
ICD-10 Finland
Degenerative myopia
13.8
6.9
11
8
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
2.3
6.9
48
209
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.3
6.8
447
3505
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.4
6.7
259
1862
H54.5
ICD-10 Finland
Severe visual impairment, monocular
5.9
6.6
17
29
F28
ICPC
Limited function/disability (F)
3.7
6.5
20
55
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
3.7
6.5
20
55
CHC05
NOMESCO Finland
Iridotomy
2.4
6.5
41
171
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.0
6.4
69
356
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
6.4
479
3829
CK2X4, ,
SPAT
8.2
6.3
13
16
UJF32
NOMESCO Finland
Coloscopy
1.3
6.3
606
5003
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
+∞
6.3
6
*
3625D
ICD-9 Finland
Other retinal disorders, Degeneration of macula and posterior pole[CYSTA MACULAE (""""MACULAR HOLE"""")]
+∞
6.3
6
*
R53
ICD-10 Finland
Malaise and fatigue
1.3
6.2
492
3959
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.3
6.2
45
200
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.5
6.0
36
146
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
2272
21129
6.78
31.93
31.9
28.8
91.75
91.82
fl
0.31
2250
20846
2272
21130
6.77
31.90
32.0
28.9
245.81
247.21
e9/l
0.46
2230
20630
2272
21131
6.77
31.88
32.0
28.9
4.39
4.39
e12/l
0.16
2218
20532
2272
21131
6.77
31.88
32.0
28.9
6.76
6.78
e9/l
0.16
2216
20537
2272
21131
6.77
31.88
32.5
29.4
39.69
39.62
%
0.23
2250
20840
2272
21133
6.76
31.83
32.3
29.1
132.52
132.39
g/l
0.16
2250
20857
2265
21033
5.78
31.46
28.3
25.5
81.65
79.35
umol/l
1.84
2249
20756
2192
19967
3.05
30.92
7.0
6.5
2.55
2.61
mmol/l
2.81
2032
18253
2248
20806
4.43
30.44
15.0
13.7
23.68
24.75
u/l
2.47
2186
20088
2243
20793
4.07
28.95
25.7
23.2
3.99
3.99
mmol/l
0.22
2211
20361
2241
20764
3.99
28.92
25.3
22.9
139.65
139.69
mmol/l
0.35
2214
20363
2129
19270
2.39
27.73
7.8
7.1
40.17
39.77
mmol/mol
1.36
1976
17745
2147
19554
2.46
26.68
6.0
5.6
4.49
4.57
mmol/l
2.91
1989
17950
2153
19722
2.42
24.81
6.1
5.9
6.04
6.01
mmol/l
0.47
1965
17835
2123
19406
2.21
23.38
5.8
5.5
1.50
1.50
mmol/l
0.07
1953
17681
2067
18756
2.00
22.48
6.0
5.8
2.02
2.03
mu/l
0.16
1913
17038
1816
15885
1.68
22.09
26.8
23.8
13.85
13.85
%
0.03
1790
15667
2108
19320
2.08
21.37
21.5
18.9
73.14
74.18
ml/min/173m2
1.93
1982
18091
2144
19809
2.20
20.73
21.1
18.9
25.33
26.25
mg/l
0.61
1824
16639
1132
9193
1.46
17.02
3.3
3.1
138.78
147.13
ug/l
0.65
1039
8419
2022
18603
1.71
15.76
4.9
4.6
1.28
1.28
mmol/l
0.03
1835
16715
1779
15915
1.52
15.25
4.6
4.6
14.96
15.08
pmol/l
1.26
1600
14380
1764
15842
1.49
14.00
5.1
4.7
14.10
14.11
mm/h
0.01
1651
14722
848
6697
1.42
13.95
3.8
3.5
0.52
0.46
e6/l
0.29
627
4958
1644
14606
1.44
13.46
5.6
5.3
238.00
1580.00
e6/l
2.30
12
213
1859
16969
1.50
12.71
9.4
8.8
80.87
81.49
u/l
0.17
1753
16053
946
7723
1.38
12.39
4.0
3.6
111.73
84.20
e6/l
0.17
711
5928
1034
8579
1.37
12.18
4.8
4.2
127.46
109.37
e6/l
0.19
728
6132
1257
10803
1.36
11.62
2.4
2.3
96.18
95.31
pmol/l
0.26
673
5482
1061
8896
1.36
11.44
2.1
2.0
1.28
1.31
mmol/l
0.42
852
7282
1417
12435
1.36
11.30
7.1
7.4
1.22
1.21
mmol/l
0.29
1251
10709
620
4779
1.41
11.19
4.4
4.2
350.32
568.60
ng/l
0.53
542
4060
1421
12495
1.36
11.06
10.0
10.0
4.27
4.16
e9/l
1.06
1232
10751
1252
10850
1.34
10.45
4.9
5.1
35.05
35.01
g/l
0.09
1177
10159
1110
9459
1.34
10.36
14.1
12.6
0.00
0.00
e9/l
1.11
920
7643
1323
11567
1.34
10.35
4.6
4.4
0.01
0.14
estimate
0.47
273
2376
772
6235
1.36
10.30
2.6
2.4
2.88
2.93
mg/l
0.24
676
5331
1298
11321
1.34
10.30
4.6
4.4
0.00
0.00
estimate
0.50
280
2445
1311
11460
1.33
10.20
4.6
4.4
11.48
3.02
estimate
0.51
294
2529
1501
13417
1.34
9.84
5.5
5.1
6.81
6.72
mmol/l
0.98
1445
12832
1287
11254
1.33
9.81
6.7
6.6
1.21
1.21
mmol/l
0.25
1190
10373
1179
10206
1.32
9.54
2.6
2.5
80.96
80.37
nmol/l
0.28
1045
9043
675
5408
1.35
9.29
3.1
2.8
4.91
5.59
e6/l
0.80
601
4939
532
4119
1.38
9.07
3.0
2.7
11.94
12.28
umol/l
0.53
498
3842
501
3847
1.39
8.97
3.0
2.7
2.26
2.27
g/l
0.11
458
3543
654
5239
1.35
8.95
5.2
5.0
21.82
21.95
%
0.08
355
2838
1268
11187
1.30
8.47
7.4
6.3
1.83
1.90
e9/l
0.85
1124
9650
1283
11338
1.30
8.46
7.6
6.4
0.19
0.19
e9/l
0.14
1128
9713
492
3818
1.37
8.17
3.6
3.5
0.78
0.80
ug/l
0.17
374
2759
499
3883
1.36
8.14
3.6
3.3
1.87
2.65
e6/l
1.32
251
1913
466
3591
1.37
8.08
3.1
2.7
21.66
21.84
%
0.11
437
3335
536
4235
1.35
7.89
3.5
3.1
1.30
1.20
e6/l
0.12
290
2280
636
5160
1.32
7.80
2.9
3.2
2.47
2.47
mmol/l
0.13
575
4633
702
5817
1.30
7.28
4.9
4.2
86.68
87.56
%
0.44
685
5693
475
3737
1.34
7.12
2.2
2.0
30.06
29.77
s
0.47
462
3625
701
5842
1.29
6.88
3.7
3.3
0.00
0.06
1.74
16
180
951
8233
1.26
6.83
3.7
3.3
6.94
6.95
mmol/l
0.04
782
6858
937
8104
1.26
6.77
3.6
3.3
1619.41
1411.06
ng/l
0.77
817
7107
1113
9831
1.26
6.67
2.4
2.3
—
—
—
0
0
771
6530
1.27
6.59
6.5
6.2
2.51
3.35
ug/l
2.05
695
5818
859
7371
1.26
6.58
1.8
1.8
20.35
20.73
nmol/l
0.31
721
6146
1260
11332
1.25
6.28
16.7
17.3
1.30
1.30
inr
0.12
1033
9442
951
8289
1.25
6.28
4.5
4.1
8.58
8.12
mg/mmol
0.10
581
5005
970
8498
1.24
6.05
3.4
3.7
2.36
2.36
mmol/l
0.43
883
7616
1367
12435
1.24
6.03
3.4
3.4
50.09
54.56
u/l
0.84
1267
11393
320
2432
1.37
5.95
2.5
2.6
66.59
68.50
e9/l
0.46
235
1776
535
4390
1.28
5.78
1.3
1.3
0.89
1.39
u/ml
1.70
129
1078
870
7565
1.24
5.72
2.3
2.2
171.77
218.95
u/l
1.81
808
7129
33
133
2.50
5.62
1.2
1.2
16.48
22.85
u/l
0.57
27
112
135
882
1.56
5.54
1.8
1.8
40.66
39.05
u/l
0.38
122
773
475
3867
1.29
5.43
1.6
1.5
2.64
2.62
g/l
0.06
272
2163
285
2180
1.35
5.08
2.5
2.4
32.24
38.11
u/l
1.74
239
1836
33
140
2.38
5.07
1.2
1.2
98.82
85.07
u/l
0.27
28
123
216
1596
1.39
4.78
6.8
8.6
24.31
24.33
mmol/l
0.04
211
1570
223
1663
1.38
4.67
3.5
3.0
10.61
10.51
g/l
0.11
208
1523
1335
12285
1.21
4.62
6.6
7.0
11.67
11.75
umol/l
0.07
1264
11724
378
3057
1.28
4.50
6.2
7.1
0.79
0.99
mmol/l
0.44
324
2526
82
501
1.66
4.49
2.6
2.2
65.19
85.28
ug/min
0.29
48
290
296
2326
1.31
4.38
6.1
6.8
1.29
1.33
mmol/l
0.29
291
2286
93
592
1.59
4.33
1.5
1.5
0.29
11.96
iu/ml
0.56
18
113
549
4658
1.23
4.32
2.1
1.8
1.04
1.49
mg/l
5.31
424
3687
100
649
1.57
4.30
3.1
3.6
0.64
1.94
index
3.45
50
329
342
2749
1.29
4.27
6.4
7.3
95.78
95.55
%
0.48
333
2647
35
165
2.14
4.25
2.9
2.3
627.71
623.79
ml
0.02
24
112
379
3088
1.27
4.25
6.1
7.1
5.06
5.12
kpa
0.49
367
2967
379
3088
1.27
4.25
6.1
7.1
11.91
12.21
kpa
0.49
368
2967
47
254
1.87
3.95
1.2
1.2
46.69
61.10
u/l
1.94
39
226
274
2163
1.30
3.93
3.1
3.1
188.94
208.92
ng/l
0.41
257
1998
218
1669
1.34
3.88
7.7
8.8
0.59
0.63
%
0.92
218
1660
513
4367
1.22
3.87
1.8
1.8
1158.07
1153.84
nmol/l
0.03
373
3288
666
5817
1.20
3.86
3.0
2.9
356.04
347.10
umol/l
1.37
562
5036
162
1196
1.38
3.65
2.1
2.2
12.25
12.55
nmol/l
0.16
142
1047
782
6962
1.19
3.63
3.2
3.3
32.45
35.86
u/l
0.66
732
6524
223
1735
1.32
3.57
7.5
8.5
1.25
1.26
%
0.09
223
1725
315
2564
1.26
3.55
6.8
7.7
119.71
120.02
g/l
0.10
310
2496
336
2767
1.25
3.43
1.3
1.4
—
—
—
0
0
312
2553
1.26
3.37
3.9
3.5
5.74
5.81
kpa
0.54
301
2492
1129
10403
1.17
3.36
2.9
2.9
—
—
estimate
—
0
0
445
3785
1.22
3.35
1.4
1.3
74.72
37.95
iu/ml
1.10
144
1183
320
2634
1.25
3.28
2.9
2.6
8.96
8.47
umol/l
0.13
273
2326
120
859
1.42
3.26
2.0
1.7
10.14
7.42
iu/ml
0.43
27
198
173
1320
1.34
3.19
2.1
1.9
1.33
1.44
g/l
0.24
156
1192
362
3030
1.23
3.19
5.0
4.6
245.09
249.95
u/l
0.15
340
2854
389
3291
1.22
3.09
2.0
1.9
—
—
—
0
0
302
2490
1.24
3.06
3.7
3.8
—
—
—
0
0
916
8358
1.16
2.99
4.7
4.4
0.48
0.36
estimate
0.09
233
1968
194
1522
1.30
2.96
7.5
9.2
16.11
15.79
%
0.87
189
1465
161
1234
1.33
2.90
3.5
3.4
4.46
4.40
pmol/l
0.37
145
1083
80
546
1.48
2.83
1.9
1.9
13.66
12.62
mg/l
0.48
74
497
361
3058
1.21
2.83
2.1
1.9
—
—
—
0
0
723
6506
1.16
2.80
4.7
4.5
0.01
0.00
estimate
0.31
258
2240
152
1163
1.33
2.78
1.3
1.3
209.82
211.12
u/ml
0.01
143
1071
260
2149
1.24
2.59
3.2
2.9
4.62
4.46
kpa
0.51
252
2094
31
171
1.82
2.54
2.5
3.0
28.80
29.81
mg/l
0.06
25
129
295
2478
1.22
2.52
4.0
3.5
1.24
1.97
mmol/l
2.22
263
2187
133
1015
1.33
2.51
2.4
2.6
0.43
0.98
g/l
1.43
107
871
102
747
1.38
2.50
1.6
1.6
12.54
26.80
u/ml
1.97
21
110
100
731
1.38
2.48
1.5
1.4
269.75
274.12
ug/g
0.08
57
432
113
846
1.35
2.43
1.9
2.5
0.09
0.03
g/l
0.32
98
763
171
1360
1.28
2.39
2.6
2.5
34.30
21.93
au/ml
0.63
14
94
276
2317
1.22
2.38
7.1
6.7
10.01
10.47
mmol/l
0.54
264
2214
474
4179
1.17
2.36
3.0
3.2
0.81
0.81
mmol/l
0.16
441
3927
634
5725
1.15
2.28
4.3
3.9
0.02
0.16
estimate
0.53
211
1883
63
431
1.47
2.27
1.4
1.2
39.18
55.95
u/ml
—
10
45
564
5058
1.15
2.23
1.9
1.8
14318646.39
29027245.54
pmol/l
0.44
440
4141
409
3580
1.17
2.23
1.3
1.3
14.73
14.15
u/ml
0.05
154
1244
382
3325
1.18
2.23
6.0
5.6
1.02
1.03
mmol/l
0.40
352
3058
36
217
1.67
2.22
1.1
1.3
0.61
0.65
ratio
—
7
57
75
536
1.41
2.16
1.2
1.3
—
—
—
0
0
289
2463
1.20
2.15
2.1
2.1
0.21
0.20
g/l
0.31
260
2296
126
981
1.30
2.10
3.5
3.6
36.17
67.40
mg/l
1.18
103
840
107
815
1.33
2.09
2.0
2.5
0.00
0.00
g/l
-0.00
89
720
63
439
1.45
2.09
3.9
5.1
105.60
676.26
iu/ml
—
5
66
24
132
1.83
2.03
1.1
1.6
—
—
—
0
0
24
132
1.83
2.03
1.1
1.6
—
—
—
0
0
138
1094
1.28
2.02
1.9
2.6
2.97
2.93
g/l
0.17
122
989
59
410
1.45
2.00
1.2
1.2
—
—
—
0
0
28
163
1.73
1.98
1.3
1.5
—
—
—
0
0
963
8998
1.12
1.97
4.6
4.2
39.04
109.42
ng/l
0.89
759
6960
40
257
1.57
1.95
1.2
1.3
1.59
1.59
g/l
0.03
40
257
125
985
1.28
1.93
3.5
3.6
60.28
112.04
mg/l
0.46
100
845
631
5756
1.13
1.92
2.6
2.5
—
—
—
0
0
21
113
1.87
1.91
1.0
1.1
—
—
—
0
0
245
2085
1.20
1.87
2.4
2.3
372.82
382.53
nmol/l
0.33
223
1913
29
175
1.67
1.83
1.0
1.1
—
—
—
0
0
25
145
1.73
1.81
1.3
1.6
—
—
—
0
0
39
255
1.54
1.79
1.6
1.5
—
—
—
0
0
37
239
1.56
1.79
1.3
1.2
3.89
5.53
u/ml
0.44
19
105
78
583
1.35
1.77
1.4
1.2
25.35
3.40
u/ml
0.43
13
53
152
1245
1.24
1.72
1.4
1.3
35.03
58.69
au/ml
1.59
12
85
78
586
1.34
1.72
1.5
1.3
4.27
7.42
u/ml
0.56
15
87
98
761
1.30
1.72
2.0
2.5
0.00
0.00
g/l
-0.00
89
719
265
2297
1.17
1.66
2.4
2.8
66.10
66.15
g/l
0.03
244
2104
25
150
1.67
1.63
1.3
1.6
—
—
—
0
0
26
159
1.64
1.59
1.0
1.1
—
—
—
0
0
70
525
1.34
1.58
1.4
1.4
—
—
—
0
0
59
431
1.38
1.57
1.1
1.3
104.00
460.47
titre
—
5
43
237
2046
1.18
1.57
4.3
3.7
87.73
90.80
ng/l
0.25
199
1734
67
500
1.35
1.57
1.5
1.3
—
—
—
0
0
67
500
1.35
1.57
1.5
1.3
—
—
—
0
0
142
1170
1.23
1.55
1.9
2.6
7.56
7.49
g/l
0.23
127
1064
142
1170
1.23
1.55
1.9
2.6
4.13
4.20
g/l
0.65
127
1066
67
505
1.34
1.48
1.4
1.2
19.40
4.74
u/ml
—
6
31
110
887
1.25
1.47
3.4
3.5
3.92
2.64
ratio
0.25
61
507
25
155
1.62
1.47
1.6
1.5
6.76
7.42
u/l
0.08
17
129
25
155
1.62
1.47
1.0
1.1
—
—
—
0
0
141
1169
1.22
1.46
1.9
2.6
3.88
3.62
g/l
0.93
126
1064
26
163
1.60
1.46
1.0
1.1
—
—
—
0
0
26
163
1.60
1.46
1.0
1.1
—
—
—
0
0
474
4321
1.12
1.44
2.1
2.0
—
—
—
0
0
7
151
0.46
1.43
1.6
1.9
—
—
—
0
0
238
2076
1.16
1.40
2.4
2.4
5.84
7.34
ug/l
1.29
211
1836
197
1693
1.18
1.40
1.9
1.7
—
—
—
0
0
206
1777
1.17
1.40
1.6
1.5
—
—
—
0
0
159
1341
1.20
1.39
3.0
2.4
0.62
0.61
%
0.14
159
1334
98
786
1.26
1.38
1.3
1.2
0.29
1.00
u/ml
—
8
59
33
478
0.69
1.36
4.9
3.7
33.23
27.74
mg/l
0.27
24
334
87
690
1.27
1.35
1.5
1.7
—
—
—
0
0
113
925
1.23
1.34
2.6
2.7
—
—
—
0
0
328
2939
1.14
1.33
3.6
4.3
16.40
19.45
ug/l
0.17
280
2423
137
1147
1.21
1.31
2.4
2.3
0.00
0.00
estimate
0.50
45
338
75
587
1.29
1.30
1.6
1.5
—
—
—
0
0
159
1351
1.19
1.30
2.9
2.5
1.02
1.12
%
1.76
159
1343
144
1216
1.20
1.27
1.4
1.5
—
—
—
0
0
48
354
1.36
1.26
1.3
1.3
0.14
0.39
nmol/l
—
5
21
8
36
2.23
1.24
1.0
1.1
—
—
—
0
0
544
5040
1.10
1.23
4.9
4.6
1.02
1.02
kg/l
0.55
377
3422
29
197
1.48
1.19
1.0
1.1
0.80
1.69
eliau/ml
—
9
53
18
109
1.66
1.18
1.8
1.5
1.36
2.23
u/field
0.61
11
71
268
2995
0.88
1.18
5.9
5.4
32.75
33.48
%
0.58
179
1874
40
290
1.39
1.17
1.3
1.1
315.74
299.70
u/ml
0.15
27
164
18
110
1.64
1.15
1.7
1.2
1.17
1.25
nmol/l
—
10
80
43
317
1.36
1.15
1.4
1.6
—
—
—
0
0
773
7306
1.09
1.13
2.7
2.7
55.13
72.47
u/l
0.92
700
6720
80
646
1.25
1.11
3.3
2.7
1.78
1.72
mg/l
0.18
69
579
10
51
1.96
1.11
2.0
1.8
—
—
—
0
0
29
411
0.70
1.10
1.6
1.5
—
—
—
0
0
7
31
2.26
1.10
1.0
1.1
—
—
—
0
0
62
487
1.28
1.09
1.5
1.2
—
—
—
0
0
35
253
1.39
1.06
1.4
1.2
4.27
3.70
u/ml
0.07
15
83
79
643
1.24
1.04
3.0
3.3
0.77
0.80
nmol/l
0.26
64
530
119
1010
1.19
1.03
1.9
2.6
10.19
10.14
g/l
0.04
103
896
29
204
1.43
1.03
1.4
1.6
—
—
—
0
0
25
171
1.47
1.02
1.6
1.7
78.97
104.08
ng/l
2.03
25
171
28
197
1.43
1.00
1.0
1.1
—
—
—
0
0
28
197
1.43
1.00
1.7
1.6
—
—
—
0
0
20
131
1.53
0.99
4.5
3.8
—
—
—
0
0
58
458
1.27
0.99
1.3
1.4
—
—
—
0
0
209
1860
1.14
0.99
1.6
1.6
—
—
—
0
0
9
49
1.84
0.98
1.4
1.3
—
—
—
0
0
20
295
0.68
0.96
2.8
3.8
55.90
58.49
%
0.20
20
251
23
330
0.69
0.96
3.6
2.3
25.78
21.75
mg/l
—
10
110
26
182
1.43
0.96
1.2
1.2
139.31
105.45
pmol/l
1.52
26
182
15
93
1.62
0.93
1.1
1.2
—
—
—
0
0
37
278
1.34
0.92
4.6
3.9
—
—
—
0
0
76
629
1.22
0.89
1.4
1.6
—
—
—
0
0
5
105
0.48
0.88
1.0
1.2
206.80
383.88
u/l
—
5
98
6
114
0.53
0.82
1.5
1.6
—
—
—
0
0
6
114
0.53
0.82
1.5
1.6
—
—
—
0
0
6
114
0.53
0.82
1.5
1.6
—
—
—
0
0
6
114
0.53
0.82
1.5
1.6
—
—
—
0
0
14
89
1.58
0.81
2.4
2.0
0.63
0.61
mmol/l
0.64
14
89
10
58
1.73
0.79
1.2
1.5
12.22
9.29
ug/l
—
10
58
69
574
1.21
0.79
1.2
1.1
—
—
—
0
0
6
33
1.82
0.79
12.7
15.7
4.37
5.18
mmol/l
—
6
33
47
375
1.26
0.78
1.4
1.5
—
—
—
0
0
21
148
1.42
0.77
1.1
1.2
0.20
1.68
u/ml
0.96
16
83
55
448
1.23
0.77
1.4
1.5
—
—
—
0
0
27
200
1.35
0.76
1.0
1.1
0.41
1.31
u/ml
0.96
14
114
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
19
132
1.44
0.76
1.1
1.1
0.76
0.68
u/ml
—
10
71
76
642
1.19
0.75
1.6
1.7
—
—
—
0
0
87
745
1.17
0.74
1.2
1.3
—
—
—
0
0
18
125
1.44
0.72
7.0
6.9
16.84
27.89
ug/l
0.26
13
78
13
194
0.67
0.71
1.3
1.5
—
—
—
0
0
13
194
0.67
0.71
1.3
1.5
—
—
—
0
0
13
194
0.67
0.71
1.3
1.5
—
—
—
0
0
16
109
1.47
0.71
1.1
1.1
2.92
12.93
iu/ml
—
5
33
224
2050
1.10
0.70
3.7
4.1
1.23
1.23
mmol/l
0.26
181
1795
5
27
1.85
0.68
1.6
1.6
65.20
44.81
umol/l
—
5
27
9
59
1.53
0.68
1.0
1.2
—
—
—
0
0
9
59
1.53
0.68
1.0
1.1
—
—
—
0
0
67
566
1.19
0.68
1.2
1.2
—
—
—
0
0
5
28
1.79
0.66
1.2
1.0
—
—
—
0
0
13
86
1.51
0.66
1.2
1.3
114.62
165.90
mmol/24h
1.80
13
86
39
483
0.80
0.66
1.6
1.5
219.59
268.03
pmol/l
0.14
39
471
27
206
1.31
0.65
1.1
1.2
13.82
12.14
u/l
0.30
22
185
136
1217
1.12
0.65
4.1
4.8
1.51
1.54
%
0.30
129
1140
39
313
1.25
0.65
1.5
1.6
—
—
—
0
0
261
2417
1.09
0.65
2.5
2.1
147.18
150.19
ug/g
0.05
201
1904
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
103
907
1.14
0.63
2.7
3.0
0.31
0.36
iu/ml
0.82
49
503
138
1239
1.12
0.63
4.1
3.7
1.02
1.02
ratio
0.16
124
1131
0
20
0.00
0.60
0.0
1.2
—
9.74
—
0
20
74
639
1.16
0.60
1.5
1.6
8504.08
13255.69
e6/l
1.17
51
442
0
22
0.00
0.59
0.0
1.3
—
14.27
—
0
22
35
283
1.24
0.56
3.5
5.0
325.37
356.56
umol/l
0.50
29
252
6
36
1.67
0.56
1.3
1.3
—
—
—
0
0
176
1616
1.10
0.55
6.6
6.5
24.93
24.59
mmol/l
0.69
171
1541
42
348
1.21
0.55
1.8
1.2
—
19.11
—
0
7
64
553
1.16
0.53
1.8
1.9
6.74
14.69
iu/l
0.32
24
210
87
769
1.14
0.53
1.3
1.3
—
—
—
0
0
37
304
1.22
0.53
1.9
1.3
145.56
161.59
au/ml
0.49
16
94
76
667
1.14
0.52
1.4
1.4
—
—
—
0
0
78
686
1.14
0.52
4.8
3.9
3.82
3.89
mmol/l
0.82
78
680
60
519
1.16
0.50
2.4
2.5
31.85
33.58
umol/l
0.19
48
460
16
118
1.36
0.50
1.6
1.7
39.29
39.54
g/l
0.08
16
118
72
632
1.14
0.50
1.5
1.6
—
—
—
0
0
23
180
1.28
0.49
1.2
1.3
—
—
—
0
0
25
198
1.27
0.49
1.3
1.3
1.25
1.58
nmol/l
1.00
20
181
12
84
1.43
0.49
1.3
1.0
—
—
—
0
0
7
46
1.52
0.48
1.1
1.2
—
—
—
0
0
23
181
1.27
0.48
1.2
1.3
—
—
—
0
0
19
244
0.78
0.47
1.4
1.6
—
—
—
0
0
21
164
1.28
0.46
1.3
1.1
—
—
—
0
0
5
83
0.60
0.45
1.6
1.7
—
—
—
0
0
5
83
0.60
0.45
1.6
1.7
—
—
—
0
0
5
85
0.59
0.45
1.4
1.7
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
15
112
1.34
0.44
1.1
1.1
—
—
—
0
0
12
86
1.40
0.44
1.2
1.4
—
—
—
0
0
266
2815
0.94
0.44
8.3
7.1
—
—
—
0
0
69
612
1.13
0.43
1.5
1.5
—
—
—
0
0
180
1678
1.08
0.43
1.7
1.7
1.51
1.56
%
0.37
151
1404
50
434
1.16
0.42
1.4
1.3
—
—
—
0
0
24
194
1.24
0.42
1.9
1.9
2.33
1.26
u/field
0.57
12
92
10
139
0.72
0.42
2.1
2.3
—
—
—
0
0
138
1274
1.09
0.42
1.6
1.7
1.42
1.58
g/l
1.41
119
1100
25
305
0.82
0.41
1.3
1.4
—
—
—
0
0
24
294
0.81
0.41
1.5
1.3
123.67
212.21
miu/ml
1.13
12
95
18
228
0.79
0.41
1.4
1.6
—
—
—
0
0
93
843
1.11
0.41
1.2
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
50
436
1.15
0.40
1.2
1.2
24.68
40.40
u/l
1.07
45
379
80
887
0.90
0.40
1.6
1.8
—
—
—
0
0
40
343
1.17
0.40
1.0
1.1
—
—
—
0
0
28
232
1.21
0.40
3.7
3.6
13.31
11.17
index
0.54
16
122
121
1115
1.09
0.39
4.2
5.0
0.87
0.87
%
0.01
114
1047
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
49
429
1.15
0.38
1.5
1.7
—
—
—
0
0
31
261
1.19
0.38
1.3
1.3
347.34
334.07
u/l
0.08
31
250
74
666
1.11
0.38
1.6
1.6
0.19
0.33
mg/l
3.59
27
280
8
113
0.71
0.37
1.8
3.4
1.13
1.24
%
—
8
113
31
262
1.19
0.37
1.3
1.3
13.98
12.02
u/l
0.18
24
203
213
2013
1.06
0.36
2.9
2.5
0.48
0.51
e6/l
0.11
208
1930
9
71
1.27
0.36
1.3
1.2
—
—
—
0
0
13
167
0.78
0.34
1.0
1.1
—
—
—
0
0
6
46
1.31
0.33
1.8
2.2
—
—
—
0
0
20
242
0.82
0.32
1.5
1.4
57438.50
92887.38
e6/l
0.23
14
160
88
957
0.92
0.32
1.7
1.9
—
—
—
0
0
81
884
0.91
0.32
1.0
1.0
—
—
—
0
0
6
47
1.28
0.32
1.2
1.0
—
—
—
0
0
101
934
1.09
0.32
1.9
2.2
447.81
715.80
ug/l
0.45
96
887
70
769
0.91
0.32
2.0
1.9
3.41
3.46
mmol/l
0.17
50
571
131
1225
1.07
0.32
1.3
1.2
170.73
136.87
u/ml
0.31
36
431
32
276
1.16
0.31
1.3
1.6
42.30
60.91
%
1.52
20
168
21
174
1.21
0.31
1.2
1.3
—
—
—
0
0
14
111
1.26
0.30
1.0
1.1
—
—
—
0
0
90
832
1.09
0.29
4.4
3.5
1.33
1.37
mmol/l
0.19
90
816
32
279
1.15
0.28
3.3
4.7
6.80
7.18
mmol/l
0.45
27
235
35
308
1.14
0.28
1.4
1.3
0.22
0.19
nmol/l
1.03
26
248
9
120
0.75
0.27
4.0
3.8
13.54
13.47
%
—
9
120
16
131
1.22
0.27
1.9
2.0
—
—
—
0
0
28
243
1.15
0.27
1.1
1.1
—
—
—
0
0
116
1090
1.07
0.26
2.1
1.9
3.05
2.26
ug/l
0.29
104
965
12
95
1.26
0.26
1.2
1.1
—
—
—
0
0
21
178
1.18
0.26
6.3
5.6
36.31
39.42
u/ml
—
7
56
51
463
1.10
0.25
1.5
1.3
859.97
865.97
e6/l
0.00
31
362
10
78
1.28
0.24
2.6
2.8
9.00
10.49
kpa
—
10
78
10
78
1.28
0.24
2.6
2.8
4.76
4.89
kpa
—
10
78
6
82
0.73
0.24
1.0
1.3
—
—
—
0
0
20
233
0.86
0.23
1.4
1.3
—
—
—
0
0
49
537
0.91
0.23
1.4
1.4
—
—
—
0
0
50
457
1.10
0.23
1.3
1.3
4.28
48.20
e6/l
1.59
29
333
11
88
1.25
0.22
1.2
1.2
—
—
—
0
0
11
88
1.25
0.22
1.0
1.4
2.44
3.31
mmol/l
0.80
11
78
44
483
0.91
0.22
1.5
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
90
847
1.07
0.21
4.0
3.9
24.62
25.02
mmol/l
0.70
85
771
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
15
177
0.85
0.21
1.3
1.5
—
1472.00
—
0
5
169
1621
1.05
0.21
4.1
3.7
5.13
5.15
kpa
0.10
158
1548
43
469
0.92
0.20
2.7
3.9
72.41
35.21
u/ml
0.38
43
456
6
50
1.20
0.19
1.5
1.3
3.67
2.15
umol/l
—
6
39
15
127
1.18
0.19
1.1
1.1
—
—
—
0
0
119
1134
1.05
0.19
2.1
2.1
3.35
3.37
ratio
0.09
100
936
14
165
0.85
0.19
1.0
1.2
1.84
2.31
mmol/l
2.18
14
152
6
51
1.18
0.19
3.5
1.2
—
—
—
0
0
66
617
1.07
0.19
1.3
1.2
—
—
—
0
0
36
327
1.10
0.19
1.4
1.4
—
—
—
0
0
15
128
1.17
0.18
1.1
1.5
80.60
86.14
umol/l
0.41
15
128
15
129
1.16
0.17
1.3
1.4
—
—
—
0
0
15
129
1.16
0.17
1.3
1.4
—
—
—
0
0
19
167
1.14
0.17
1.1
1.0
—
—
—
0
0
29
263
1.10
0.16
1.3
1.6
21.98
27.84
ng/l
0.48
29
263
8
69
1.16
0.16
1.1
1.2
—
—
—
0
0
8
70
1.14
0.16
1.3
1.6
84.13
577.19
nmol/24h
—
8
70
36
331
1.09
0.16
1.4
1.4
—
—
—
0
0
8
73
1.10
0.15
1.4
1.1
1285.00
1370.90
miu/ml
—
8
73
6
79
0.76
0.15
1.5
2.8
—
1858.06
—
0
17
10
83
1.21
0.15
1.0
1.3
—
—
—
0
0
57
536
1.07
0.15
5.4
6.9
103.98
105.26
mmol/l
1.01
51
473
18
159
1.13
0.15
1.7
1.7
7.62
8.24
mmol/l
0.44
18
159
36
333
1.08
0.14
1.4
1.4
—
—
—
0
0
10
84
1.19
0.14
1.3
1.1
0.49
0.50
ratio
—
5
54
55
519
1.06
0.13
1.8
1.8
4.40
5.06
mg/l
0.13
44
411
117
1210
0.97
0.12
3.4
4.3
42.48
94.00
u/ml
2.32
112
1164
33
307
1.08
0.12
2.2
2.0
4.64
1444.28
u/ml
0.89
33
301
26
282
0.92
0.12
1.0
1.1
96.67
83.62
iu/ml
—
6
47
59
562
1.05
0.11
1.8
1.6
—
—
—
0
0
23
211
1.09
0.11
1.1
1.3
—
—
—
0
0
140
1363
1.03
0.10
4.1
3.5
1.83
2.17
mmol/l
0.57
104
1021
30
280
1.07
0.10
1.3
1.4
6.00
6.35
mmol/l
0.34
30
265
15
135
1.11
0.09
1.0
1.2
—
—
—
0
0
22
203
1.08
0.09
1.4
1.3
—
—
—
0
0
5
48
1.04
0.09
2.0
2.2
—
—
—
0
0
6
57
1.05
0.08
1.7
2.4
0.58
1.26
ug/l
—
6
52
23
214
1.08
0.08
1.9
1.6
28.00
26.80
u/ml
—
6
30
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
33
312
1.06
0.08
1.5
1.4
—
—
—
0
0
5
60
0.83
0.08
1.4
2.4
21.00
532.23
ug/l
—
5
60
5
64
0.78
0.08
1.2
1.1
—
—
—
0
0
11
98
1.12
0.07
1.3
1.1
—
—
—
0
0
15
137
1.10
0.07
1.0
1.2
—
—
—
0
0
22
235
0.94
0.07
3.7
2.9
—
—
—
0
0
7
80
0.87
0.07
1.0
1.1
—
—
—
0
0
33
314
1.05
0.07
1.5
1.4
—
—
—
0
0
119
1165
1.02
0.07
3.5
3.1
25.39
25.43
mmol/l
0.05
113
1125
11
121
0.91
0.06
1.1
1.2
—
—
—
0
0
11
121
0.91
0.06
1.0
1.2
146.55
132.47
nmol/l
0.21
11
121
33
316
1.04
0.05
1.5
1.4
—
—
—
0
0
11
100
1.10
0.05
1.9
1.2
32.02
19.05
u/l
—
5
38
36
347
1.04
0.04
1.4
1.4
1304.50
4363.28
e6/l
0.63
22
240
14
149
0.94
0.03
2.2
1.9
—
—
—
0
0
28
271
1.03
0.02
1.1
1.0
—
—
—
0
0
16
168
0.95
0.02
1.3
1.3
—
—
—
0
0
184
1849
0.99
0.01
3.5
2.9
59.45
61.08
ml/min/173m2
0.27
91
836
225
2258
1.00
0.01
1.3
1.3
—
—
—
0
0
26
265
0.98
0.00
1.3
1.4
268.83
275.19
mosm/kgh2o
0.67
18
193
30
305
0.98
0.00
1.5
1.4
33953.50
61309.58
e6/l
0.46
12
163
20
199
1.01
0.00
1.0
1.0
332.93
310.93
ng/l
0.18
14
127
20
199
1.01
0.00
1.0
1.0
47.00
41.58
ng/l
0.22
14
126
23
234
0.98
0.00
1.2
1.2
—
—
—
0
0
29
286
1.01
0.00
3.4
3.3
7.16
5.61
nmol/l
0.20
29
277
10
98
1.02
0.00
1.3
1.3
—
—
—
0
0
41
406
1.01
0.00
2.4
1.9
1.56
1.65
mmol/l
0.37
41
394
11
112
0.98
0.00
1.1
1.0
—
—
—
0
0
11
112
0.98
0.00
1.0
1.3
—
—
—
0
0
61
614
0.99
0.00
3.1
2.2
119.89
125.57
g/l
0.94
45
476
105
1046
1.00
0.00
3.1
3.4
2268.56
2352.44
u/ml
0.01
91
894
7
70
1.00
0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
90
1.00
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
69
0.87
-0.00
1.2
1.1
—
—
—
0
0
20
200
1.00
-0.00
1.0
1.0
763.93
735.54
ng/l
0.08
14
123
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
83
0.96
-0.00
1.0
1.1
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.0
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.1
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.1
—
7.80
—
0
10
0
9
0.00
-0.00
0.0
1.3
—
2.44
—
0
9
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
7.56
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
1.2
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.1
146.87
211.40
iu/ml
—
6
68
Mortality – FinRegistry
↥Association
Association between endpoint MACULAR_HOLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULAR_HOLE | 0.823 [0.69, 0.98] | 0.032 |
| Birth year | 0.998 [0.99, 1.01] | 0.693 |
During the follow-up period (1.1.1998 — 31.12.2019), 473 out of 5602 females with MACULAR_HOLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULAR_HOLE | 0.685 [0.56, 0.84] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 348 out of 3044 males with MACULAR_HOLE died.
Mortality risk
Mortality risk for people of age
years, who have MACULAR_HOLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.057% | 0.114% |
| 5 | 0.428% | 0.742% |
| 10 | 1.293% | 2.0% |
| 15 | 2.573% | 3.641% |
| 20 | 4.578% | 6.087% |
Relationships between endpoints
↥Index endpoint: MACULAR_HOLE – Macular hole
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data