No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
467 |
4. Check minimum number of eventsNone |
467 |
5. Include endpointsNone |
467 |
6. Filter based on genotype QC (FinnGen only) |
417 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M21
- Name in latin
- Deformitas membri vara non alibi classificata
Similar endpoints
↥List of similar endpoints to
Varus deformity, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3785 | 2650 | 1120 |
| Only index persons | 3415 | 2455 | 960 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.08 | 0.03 |
| Only index persons | 0.08 | 0.09 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 51.91 | 55.37 | 43.69 |
| Only index persons | 51.77 | 54.93 | 43.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 417 | 329 | 88 |
| Unadjusted period prevalence (%) | 0.10 | 0.12 | 0.04 |
| Median age at first event (years) | 51.63 | 52.25 | 49.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 437
- Matched controls
- 4370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M20.1
ICD-10 Finland
Hallux valgus (acquired)
163.6
307.7
239
32
M21.1
ICD-10 Finland
Varus deformity, not elsewhere classified
+∞
307.7
377
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
116.3
179.5
92
10
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
75.1
146.9
80
13
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
145.1
131
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
18.6
144.5
129
96
M19.0
ICD-10 Finland
Primary arthrosis of other joints
29.6
132.1
92
39
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
16.6
104.0
95
72
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
22.1
95.5
74
40
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
83.0
77
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
13.3
76.5
78
70
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
59.8
56
*
ZXA00
NOMESCO Finland
Right side
5.1
59.1
182
538
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
16.3
58.9
52
36
M16.1
ICD-10 Finland
Other primary coxarthrosis
18.5
58.2
48
29
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
11.0
52.1
59
61
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
50.0
47
*
ZXA05
NOMESCO Finland
Left side
4.6
49.5
164
504
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
47.8
45
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
66.7
46.5
53
9
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
45.6
43
*
M25.5
ICD-10 Finland
Pain in joint
4.1
43.2
177
627
WX320
NOMESCO Finland
Spinalanesthesy
4.6
43.2
129
362
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
42.4
40
*
NHL20
NOMESCO Finland
Myotomy or tenotomy of foot
+∞
39.2
37
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
38.1
36
*
73803
ICD-8 Finland
Other deformities, Genu varum
+∞
35.9
34
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
12.6
35.6
36
31
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
7.2
35.0
56
88
M77.4
ICD-10 Finland
Metatarsalgia
6.0
33.9
65
123
Z25.1
ICD-10 Finland
Need for immunization against influenza
6.2
32.8
61
112
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.1
29.8
98
289
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
5.4
29.6
64
135
Z20.9
ICD-10 Finland
Contact with and exposure to unspecified communicable disease
8.6
29.5
39
49
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
86.2
29.2
32
*
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
4.1
29.1
96
284
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
80.5
27.1
30
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.6
26.5
45
75
9271
FHL
Hallux surgery
+∞
26.3
25
*
N02AX02
ATC
tramadol; systemic, rectal
2.9
26.2
205
1018
Z29.8
ICD-10 Finland
Other specified prophylactic measures
6.9
26.1
42
66
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
276.1
26.0
26
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.9
25.4
210
1070
R4110
NOMESCO Finland
Physiotherapy
3.0
25.3
161
712
R5110, ,
SPAT
4.7
25.2
64
154
M20.2
ICD-10 Finland
Hallux rigidus
74.5
25.1
28
*
M13.9
ICD-10 Finland
Arthritis, unspecified
10.6
25.0
28
28
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
9.3
23.6
29
33
M01AX05
ATC
glucosamine; oral
3.8
23.4
83
256
NHG82
NOMESCO Finland
Fusion of other tarsal joint
+∞
23.1
22
*
L04AX03
ATC
methotrexate; systemic
6.8
22.6
37
59
L17
ICPC
Foot/toe symptom/complaint
2.7
22.1
171
829
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
66.1
22.1
25
*
Z48.0
ICD-10 Finland
Attention to surgical dressings and sutures
7.4
21.5
32
46
L90
ICPC
Osteoarthrosis of knee
7.5
21.0
31
44
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
21.0
20
*
M01AH05
ATC
etoricoxib; oral
2.7
20.9
287
1825
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
220.1
20.8
21
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
19.5
20.7
31
17
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.9
20.4
47
104
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.1
20.1
60
163
L15
ICPC
Knee symptom/complaint
2.8
19.7
123
529
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
33.0
19.5
25
8
P01BA02
ATC
hydroxychloroquine; oral
6.9
19.5
31
48
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
4.5
19.4
50
121
N02AJ06
ATC
codeine and paracetamol; systemic
2.5
19.3
200
1102
TQW40
NOMESCO Finland
Remowal of suture of skin
4.6
18.8
47
111
M54.5
ICD-10 Finland
Low back pain
2.5
18.7
182
970
SPAT1229
SPAT
Assessment of need for aid
4.9
18.4
43
96
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
5.3
18.4
39
80
N03AX12
ATC
[U] gabapentin; oral
3.3
18.4
79
274
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
69.6
17.9
20
*
M79.6
ICD-10 Finland
Pain in limb
2.4
17.8
215
1256
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
17.8
17
*
B01AB05
ATC
enoxaparin; parenteral
2.6
17.1
136
655
N03AX16
ATC
[U] pregabalin
2.7
17.1
111
484
NF1AA
NOMESCO Finland
Hip X-ray examination
5.0
16.9
38
82
73799
ICD-8 Finland
Hallux valgus and varus
+∞
16.8
16
*
73801
ICD-8 Finland
Other deformities, Coxa vara
+∞
16.8
16
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
176.5
16.6
17
*
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
15.1
16.5
27
19
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.8
16.5
55
161
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
4.1
16.4
48
128
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
16.1
133
650
M22.4
ICD-10 Finland
Chondromalacia patellae
34.8
15.9
20
6
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
165.7
15.6
16
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
13.0
15.6
27
22
A07EC01
ATC
sulfasalazine; oral, rectal
6.4
15.3
26
43
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
4.5
15.2
39
94
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
33.0
14.9
19
6
M01AC06
ATC
meloxicam; systemic, rectal
2.3
14.7
165
917
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
+∞
14.7
14
*
M01AE03
ATC
ketoprofen; systemic, rectal
2.2
14.2
165
929
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
13.9
62
218
R4110, ,
SPAT
2.8
13.9
79
319
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
+∞
13.6
13
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.4
13.5
115
564
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.9
13.4
41
113
L88
ICPC
Rheumatoid/seropositive arthritis
23.4
13.0
18
8
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.2
12.7
35
89
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.6
12.3
43
130
M19.8
ICD-10 Finland
Other specified arthrosis
5.5
12.1
24
46
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
9.7
12.1
24
26
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
48.1
11.9
14
*
WX111
NOMESCO Finland
Local infiltration anesthesia
48.1
11.9
14
*
NH3EA
NOMESCO Finland
Feet X-ray examination with load
66.8
11.7
13
*
M23.8
ICD-10 Finland
Other internal derangements of knee
11.5
11.7
21
19
NHG22
NOMESCO Finland
Fusion of subtalar joint
+∞
11.5
11
*
L28
ICPC
Limited function/disability (L)
2.5
11.5
86
396
Z71.8
ICD-10 Finland
Other specified counselling
2.1
11.4
167
1011
S83.2
ICD-10 Finland
Tear of meniscus, current
4.7
11.4
27
61
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.1
11.3
140
796
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.0
11.2
33
88
S18
ICPC
Laceration/cut
2.0
11.2
202
1315
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
4.6
11.1
27
62
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
9.6
11.1
22
24
N02BF01
ATC
gabapentin; oral
3.0
11.1
53
194
M01AH01
ATC
celecoxib; oral
2.6
10.9
73
318
L01BA01
ATC
methotrexate; systemic
28.8
10.8
14
5
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
22.1
10.7
15
7
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
61.5
10.7
12
*
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
112.6
10.5
11
*
M21.0
ICD-10 Finland
Valgus deformity, not elsewhere classified
+∞
10.5
10
*
N02BE01
ATC
paracetamol; systemic, rectal
2.8
10.4
393
3317
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
10.2
109
581
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.6
10.2
34
99
SPAT1153
SPAT
Removal of sutures
2.1
10.0
125
708
EB1VA, ,
NOMESCO Finland
2.3
10.0
89
441
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
5.1
9.9
21
43
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.8
9.7
53
208
WX002
NOMESCO Finland
Sedation and analgesia
2.3
9.7
79
376
M48.0
ICD-10 Finland
Spinal stenosis
2.8
9.6
50
191
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
4.3
9.6
25
61
R52.9
ICD-10 Finland
Pain, unspecified
2.7
9.6
54
216
NH3AA, ,
SPAT
3.4
9.5
35
109
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
9.5
169
1079
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
18.0
9.5
14
8
NG1DA
NOMESCO Finland
X-ray of knees
102.2
9.5
10
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
9.4
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
9.2
128
750
M54.4
ICD-10 Finland
Lumbago with sciatica
2.3
9.2
83
412
M10.9
ICD-10 Finland
Gout, unspecified
4.6
9.2
22
50
M19.9
ICD-10 Finland
Arthrosis, unspecified
5.2
9.2
19
38
A02BC03
ATC
lansoprazole; oral
2.0
9.1
127
744
A02BC02
ATC
pantoprazole; systemic
1.9
9.1
289
2212
EB1CA
NOMESCO Finland
Tooth X-ray additional picture
2.7
8.9
52
211
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
8.8
37
125
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
8.8
99
536
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
8.7
51
208
J01DB01
ATC
cefalexin; oral
2.1
8.6
355
2936
M70.6
ICD-10 Finland
Trochanteric bursitis
2.4
8.6
66
306
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
20.5
8.5
12
6
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.2
8.5
34
112
H01.0
ICD-10 Finland
Blepharitis
2.8
8.4
44
169
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
+∞
8.4
8
*
7364B
ICD-9 Finland
Other acquired deformities of limbs, Genu valgum or varum (acquired)[GENU VARUM ACQUISITUM]
+∞
8.4
8
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
8.4
8
*
WX214
NOMESCO Finland
Plexus blockade at the ankle
+∞
8.4
8
*
NH1EA
NOMESCO Finland
Ankle X-ray examination with load or wrench
+∞
8.4
8
*
M22.1
ICD-10 Finland
Recurrent subluxation of patella
+∞
8.4
8
*
M03BC51
ATC
orphenadrine, combinations; systemic
1.9
8.3
124
741
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
8.3
170
1126
M03BC01
ATC
orphenadrine (citrate); systemic
2.0
8.2
100
556
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
8.2
58
258
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.7
8.2
19
42
M01AH02
ATC
rofecoxib; oral
2.6
8.2
51
214
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.9
8.2
24
64
L89
ICPC
Osteoarthrosis of hip
12.0
8.1
14
12
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
17.6
8.1
12
7
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
34.0
8.1
10
*
B01AF01
ATC
rivaroxaban; oral
2.8
8.0
42
161
UJF32
NOMESCO Finland
Coloscopy
2.0
8.0
109
631
TQW40, ,
SPAT
2.6
8.0
48
198
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.1
8.0
22
56
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.6
7.9
48
199
M01AB05
ATC
diclofenac; systemic, rectal
1.8
7.9
273
2101
SPAT1202
SPAT
Intra-articular injection
8.7
7.9
16
19
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.2
7.8
18
26
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.5
7.8
27
81
M25.2
ICD-10 Finland
Flail joint
45.8
7.7
9
*
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
7.7
80
420
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
18.8
7.6
11
6
M77.1
ICD-10 Finland
Lateral epicondylitis
2.7
7.6
41
160
J02AC01
ATC
fluconazole; systemic
1.8
7.6
187
1300
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
10.3
7.6
14
14
M01AE02
ATC
naproxen; oral, rectal
1.7
7.5
241
1805
WX702
NOMESCO Finland
Supraglottic ventilation device
3.1
7.4
31
105
TNX39
NOMESCO Finland
Other orthopedic bandage, unspecified region
8.6
7.4
15
18
M43.1
ICD-10 Finland
Spondylolisthesis
3.6
7.4
24
69
R51.80
ICD-10 Finland
Headache
2.1
7.4
76
397
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
7.3
7
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
7.3
7
*
NHK68
NOMESCO Finland
Shortening or lengthening osteotomy of ankle or foot
+∞
7.3
7
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.8
7.3
36
134
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.8
7.3
22
60
L13
ICPC
Hip symptom/complaint
2.1
7.2
77
407
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
7.2
84
459
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
7.2
88
489
H02AB06
ATC
prednisolone; systemic
1.7
7.1
186
1308
J01DA01
ATC
[U] cefalexin
1.7
7.1
263
2037
M54.2
ICD-10 Finland
Cervicalgia
2.6
7.1
41
166
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
3.4
7.1
25
76
L84
ICD-10 Finland
Corns and callosities
4.3
7.1
18
43
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.5
7.1
24
71
TNH33
NOMESCO Finland
Custom moulded brace, ankle or foot
8.5
6.9
14
17
SPAT1210
SPAT
Application of cast or individual aid
3.8
6.8
21
58
A02BC05
ATC
esomeprazole; systemic
1.7
6.8
169
1170
IHA10
NOMESCO Finland
Structured mapping of problematic alcohol use
17.0
6.8
10
6
ZXC84
NOMESCO Finland
Bloodless operation space
17.0
6.8
10
6
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
17.0
6.8
10
6
EC1VA, ,
NOMESCO Finland
3.2
6.7
27
89
M47.82
ICD-10 Finland
Other spondylosis, cervical region
3.8
6.7
20
54
NF1DA
NOMESCO Finland
X-ray of hips
22.9
6.7
9
*
WX213
NOMESCO Finland
Lower leg blockade
22.9
6.7
9
*
J01FA10
ATC
azithromycin; systemic
1.7
6.6
255
1979
J01AA02
ATC
doxycycline; systemic
1.8
6.6
333
2784
M01AX01
ATC
nabumetone; oral
3.9
6.6
19
50
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.2
6.5
57
278
G44.2
ICD-10 Finland
Tension-type headache
2.1
6.5
65
335
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
70.8
6.4
7
*
Z11.2
ICD-10 Finland
Special screening examination for other bacterial diseases
70.8
6.4
7
*
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
70.8
6.4
7
*
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
3.0
6.4
28
97
M09AX01
ATC
hyaluronic acid; parenteral
6.7
6.4
15
23
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.2
6.4
58
288
N06AA09
ATC
amitriptyline; systemic
2.4
6.3
42
182
N30.0
ICD-10 Finland
Acute cystitis
1.9
6.3
86
495
P01AB01
ATC
metronidazole; oral, rectal
1.7
6.3
186
1342
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.4
6.3
45
202
M96.0
ICD-10 Finland
Pseudarthrosis after fusion or arthrodesis
+∞
6.3
6
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
+∞
6.3
6
*
M16.3
ICD-10 Finland
Other dysplastic coxarthrosis
+∞
6.3
6
*
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
3.6
6.2
20
57
U02
ICPC
Urinary frequency/urgency
2.0
6.2
71
385
R69
ICD-10 Finland
Unknown and unspecified causes of morbidity
7.8
6.2
13
17
M01AB16
ATC
aceclofenac; oral
4.2
6.1
16
39
L08
ICPC
Shoulder symptom/complaint
1.9
6.1
93
554
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
6.1
130
857
NG1AA, ,
SPAT
2.5
6.1
37
154
ZXD20
NOMESCO Finland
Day surgery
2.2
6.0
54
266
SAA02
NOMESCO Finland
Basic examination of mouth
1.7
6.0
285
2309
R60.0
ICD-10 Finland
Localized oedema
2.2
6.0
52
253
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
235
1546
2.13
13.33
2.4
2.6
—
—
estimate
—
0
0
172
1039
2.08
11.89
5.2
3.4
0.00
0.01
estimate
0.80
62
375
145
834
2.11
11.33
5.5
3.4
1.02
1.02
kg/l
0.25
108
553
335
2610
2.21
11.21
5.9
3.4
11.48
11.39
mm/h
0.05
321
2415
20
20
10.42
10.62
1.3
1.0
—
—
—
0
0
104
565
2.10
9.21
1.5
1.2
31.05
17.30
iu/ml
0.76
33
149
258
1902
1.87
9.16
5.1
3.5
0.00
0.00
estimate
-0.00
66
388
256
1889
1.86
8.99
5.1
3.5
0.00
0.00
estimate
0.50
64
388
216
1513
1.85
8.97
11.2
10.3
1.16
1.18
inr
0.35
192
1265
258
1918
1.84
8.75
5.2
3.6
0.00
0.03
estimate
1.23
62
376
164
1061
1.87
8.71
3.5
3.1
6.28
0.02
estimate
0.49
40
305
205
1443
1.79
8.13
4.9
3.4
0.07
0.05
estimate
0.13
41
311
126
766
1.91
8.00
2.9
2.5
6.51
7.32
e6/l
0.21
119
699
92
504
2.05
7.87
1.5
1.1
9.67
1.37
u/ml
0.74
30
200
22
60
3.81
7.28
1.9
1.8
—
—
—
0
0
230
1719
1.71
7.05
3.1
2.5
81.65
77.75
nmol/l
1.38
222
1556
213
1560
1.71
7.02
2.2
2.0
97.74
98.31
pmol/l
0.06
117
797
165
1139
1.72
6.67
2.4
2.4
57.42
68.26
u/l
0.88
158
1055
336
2816
1.84
6.63
8.1
7.7
78.24
78.58
u/l
0.05
325
2660
252
1951
1.69
6.60
5.2
6.8
9.74
11.25
umol/l
1.60
245
1860
263
2083
1.66
6.11
9.9
9.8
3.79
4.06
e9/l
1.44
240
1800
209
1567
1.64
6.00
4.6
5.2
36.11
36.12
g/l
0.00
203
1489
258
2062
1.61
5.54
5.4
4.6
6.37
6.61
mmol/l
0.94
252
1942
232
1808
1.60
5.53
3.5
2.9
81.02
107.53
ug/l
3.00
227
1688
115
754
1.71
5.43
2.6
2.6
337.17
329.50
umol/l
0.34
106
672
231
1811
1.58
5.28
7.3
7.2
1.22
1.22
mmol/l
0.01
207
1559
212
1636
1.57
5.14
2.0
1.9
1.29
1.33
mmol/l
0.39
180
1362
90
562
1.76
5.02
2.9
2.8
4.28
3.83
e6/l
0.15
60
251
21
73
2.97
4.83
2.2
3.7
6.47
7.19
pmol/l
0.21
21
73
15
42
3.66
4.80
1.4
2.5
31.40
31.05
pg
0.10
15
42
178
1336
1.56
4.78
2.9
3.9
2.35
2.37
mmol/l
1.07
169
1223
132
942
1.57
4.34
2.8
3.3
695.21
993.15
ng/l
1.17
115
801
395
3622
1.94
4.14
18.3
13.2
19.01
24.50
mg/l
3.47
339
2803
204
1614
1.50
4.12
7.2
6.3
1.21
1.22
mmol/l
0.42
198
1480
112
778
1.59
4.11
1.5
1.8
1.22
1.36
mg/l
0.17
89
596
34
164
2.16
4.04
12.1
9.0
16.77
15.76
%
1.90
34
154
36
180
2.09
3.91
1.5
1.4
—
—
—
0
0
54
313
1.83
3.85
10.1
7.7
122.59
121.47
g/l
0.20
54
304
75
481
1.68
3.77
5.1
6.2
1.06
1.05
mmol/l
0.04
70
440
140
1041
1.51
3.74
1.6
1.6
21.72
20.90
nmol/l
0.26
125
883
61
370
1.75
3.74
9.4
7.2
1.53
1.11
mmol/l
0.47
50
307
133
980
1.51
3.71
3.2
3.0
0.22
0.50
e6/l
1.95
110
699
61
371
1.75
3.71
9.4
7.2
5.08
5.13
kpa
0.18
61
354
61
371
1.75
3.71
9.3
7.2
12.84
12.07
kpa
0.58
61
356
10
20
5.09
3.71
1.3
1.3
5.77
5.73
mmol/l
—
10
20
107
760
1.54
3.52
2.4
3.0
2.45
2.46
mmol/l
0.29
98
693
122
895
1.50
3.44
2.6
2.1
2.69
2.93
mg/l
0.71
112
755
383
3525
1.70
3.34
6.7
5.4
1.90
1.93
mu/l
0.19
364
3263
19
78
2.50
3.26
1.2
1.5
1.68
0.03
iu/ml
—
6
12
26
124
2.17
3.21
2.2
2.0
18.53
4.50
iu/ml
0.66
11
28
387
3580
1.71
3.20
17.3
13.3
83.12
82.10
ml/min/173m2
0.43
369
3277
403
3772
1.88
3.18
19.7
15.9
3.94
3.94
mmol/l
0.05
398
3664
379
3489
1.65
3.17
6.5
5.8
38.26
38.73
mmol/mol
0.63
371
3235
103
746
1.50
3.06
1.7
1.7
442.62
33599167.63
pmol/l
1.07
86
628
49
299
1.72
2.96
3.4
4.4
62.96
81.63
ng/l
1.40
43
262
159
1262
1.41
2.90
3.4
3.0
28.50
29.89
u/l
0.38
153
1206
34
191
1.85
2.71
7.2
7.0
24.77
24.51
mmol/l
0.20
34
180
163
1316
1.38
2.64
3.7
3.4
37.82
64.27
ng/l
0.39
114
883
21
101
2.13
2.57
1.2
1.4
—
—
—
0
0
7
16
4.43
2.48
3.3
2.9
80.77
74.29
ug/l
—
7
16
27
147
1.89
2.39
3.6
5.5
1.79
1.45
%
1.50
27
137
105
804
1.40
2.29
1.7
2.2
—
—
—
0
0
11
41
2.73
2.22
1.3
1.2
—
—
—
0
0
12
48
2.54
2.20
2.7
2.0
100.86
25.57
ng/l
0.46
12
48
8
24
3.38
2.19
1.3
5.5
124.75
147.42
nmol/l
—
8
24
39
248
1.63
2.07
1.3
1.6
—
—
—
0
0
20
104
1.97
2.04
1.1
1.2
—
—
—
0
0
412
3951
1.75
2.00
13.2
10.5
26.57
24.78
u/l
0.77
405
3820
390
3697
1.51
1.94
5.5
4.8
1.58
1.53
mmol/l
1.25
379
3431
283
2553
1.31
1.93
3.2
3.1
38.03
44.82
u/l
0.97
275
2406
11
46
2.43
1.86
1.4
1.6
—
—
—
0
0
98
769
1.35
1.83
1.5
1.4
—
—
—
0
0
22
124
1.82
1.79
1.4
2.5
2.43
2.77
g/l
0.97
22
114
87
676
1.36
1.73
3.2
3.8
92.44
340.80
ng/l
1.97
48
492
327
3031
1.31
1.69
5.9
4.4
14.95
14.71
pmol/l
1.15
310
2786
73
554
1.38
1.68
1.8
1.6
1411.69
1199.23
nmol/l
1.33
63
406
7
25
2.83
1.65
1.1
1.8
—
—
—
0
0
394
3764
1.48
1.64
6.3
5.5
2.78
2.81
mmol/l
0.29
383
3506
389
3712
1.44
1.58
5.7
4.9
4.78
4.80
mmol/l
0.11
381
3469
42
291
1.49
1.58
1.5
1.3
150.94
178.05
u/ml
0.19
16
114
19
107
1.81
1.57
1.1
1.3
—
—
—
0
0
115
945
1.29
1.55
1.3
1.3
3.26
1.85
u/ml
0.26
38
233
19
108
1.79
1.53
1.5
1.3
349.86
279.98
ug/g
0.87
14
69
421
4091
1.79
1.51
26.8
20.3
4.42
4.48
e12/l
1.76
416
3979
29
188
1.58
1.47
12.9
8.3
24.36
24.47
mmol/l
0.07
29
183
22
135
1.66
1.38
1.4
2.5
4.50
4.32
g/l
0.42
22
125
22
135
1.66
1.38
1.4
2.5
7.54
7.21
g/l
0.41
22
125
22
135
1.66
1.38
1.4
2.5
3.46
3.40
g/l
0.07
22
125
60
458
1.36
1.35
2.1
2.0
3.29
3.44
ratio
0.54
50
357
143
1226
1.25
1.35
3.3
3.3
7.11
7.16
mmol/l
0.05
130
1043
370
3522
1.33
1.35
4.7
4.1
1.25
1.25
mmol/l
0.01
358
3245
6
25
2.42
1.24
1.2
2.0
89.50
95.28
ng/l
—
6
25
37
266
1.43
1.19
1.4
1.4
—
—
—
0
0
21
135
1.58
1.13
2.0
1.5
—
—
—
0
0
124
1066
1.23
1.13
2.0
2.1
366.94
174.27
u/l
0.36
119
1013
374
3595
1.28
1.03
5.3
4.8
5.74
5.84
mmol/l
0.88
357
3305
5
23
2.19
0.98
6.0
2.5
—
—
—
0
0
0
29
0.00
0.98
0.0
1.0
—
61.48
—
0
21
0
29
0.00
0.98
0.0
1.0
—
560.50
—
0
20
130
1138
1.20
0.98
3.8
4.0
2.48
10.85
mg/mmol
4.21
79
682
54
428
1.30
0.98
2.0
1.7
1.30
1.43
%
0.69
49
379
11
62
1.79
0.95
1.2
1.4
—
—
—
0
0
25
179
1.42
0.86
1.4
1.5
—
—
—
0
0
43
342
1.29
0.78
1.8
1.8
3.79
3.49
mmol/l
1.06
30
240
9
53
1.71
0.76
1.1
1.1
—
—
—
0
0
55
454
1.24
0.75
8.8
6.4
103.60
104.22
mmol/l
0.43
55
454
5
24
2.10
0.74
1.0
1.1
—
—
—
0
0
50
409
1.25
0.73
3.7
4.6
24.86
21.45
%
0.59
13
187
23
168
1.39
0.73
2.2
2.5
39.09
39.42
u/l
0.04
23
154
7
39
1.81
0.73
2.7
1.3
—
—
—
0
0
30
230
1.33
0.71
3.1
3.0
111.14
199.61
ng/l
1.45
23
212
69
587
1.21
0.71
3.1
2.7
0.64
1.27
e6/l
2.23
38
277
5
26
1.93
0.71
1.6
1.4
—
—
—
0
0
11
69
1.61
0.69
1.3
1.3
—
—
—
0
0
249
2347
1.14
0.68
3.0
3.0
—
—
—
0
0
43
349
1.26
0.68
1.5
2.1
—
—
—
0
0
48
395
1.24
0.68
1.8
2.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
8
54
1.49
0.57
1.5
1.1
—
—
—
0
0
8
55
1.46
0.56
1.5
1.5
31.31
24.31
u/l
—
8
48
18
133
1.37
0.56
1.4
1.7
—
—
—
0
0
37
446
0.81
0.55
5.2
4.6
32.60
32.36
%
0.05
30
287
14
99
1.43
0.54
2.6
4.1
4.86
2.47
ratio
—
7
61
14
100
1.41
0.52
1.6
3.0
10.33
11.43
mg/l
0.37
14
95
28
225
1.26
0.51
4.0
4.5
24.12
24.16
mmol/l
0.03
28
220
10
144
0.69
0.50
1.6
1.5
—
—
—
0
0
16
119
1.36
0.49
1.4
2.0
—
—
—
0
0
5
83
0.60
0.46
4.2
6.5
—
389.44
—
0
16
7
50
1.41
0.45
1.0
1.0
—
—
—
0
0
32
266
1.22
0.44
5.0
3.0
62.85
67.52
ml/min/173m2
0.25
15
107
13
95
1.38
0.44
1.4
1.2
—
—
—
0
0
38
324
1.19
0.42
2.8
2.8
—
—
—
0
0
8
58
1.39
0.41
1.0
1.1
—
—
—
0
0
14
105
1.34
0.41
1.4
2.3
27557.13
5339.19
u/l
—
6
49
0
15
0.00
0.41
0.0
1.1
—
334.89
—
0
9
63
562
1.14
0.40
1.7
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
11
80
1.38
0.38
1.5
1.4
—
—
—
0
0
8
111
0.72
0.37
1.1
1.4
71.50
383.04
pmol/l
—
8
111
78
710
1.12
0.37
1.5
1.5
—
—
—
0
0
5
37
1.36
0.37
1.0
1.2
70.80
111.95
pmol/l
—
5
37
45
396
1.15
0.35
4.2
4.7
8.14
27.05
ug/l
0.54
39
333
16
199
0.80
0.34
1.3
1.7
—
—
—
0
0
40
352
1.15
0.32
2.3
2.4
27.06
39.87
u/l
1.35
33
294
15
119
1.27
0.32
1.3
2.3
9.81
10.71
g/l
0.36
15
108
14
110
1.28
0.32
1.6
1.9
—
—
—
0
0
45
401
1.14
0.31
1.8
1.9
—
—
—
0
0
7
100
0.70
0.31
1.0
1.2
—
—
—
0
0
7
100
0.70
0.31
1.0
1.2
—
—
—
0
0
12
93
1.30
0.30
4.7
2.3
—
—
—
0
0
14
172
0.81
0.28
1.1
1.2
0.83
0.92
g/l
0.81
14
172
20
234
0.85
0.25
1.1
1.0
—
—
—
0
0
9
75
1.20
0.25
1.2
1.4
—
—
—
0
0
12
96
1.26
0.24
1.2
1.1
—
1.37
—
0
11
14
168
0.83
0.23
1.1
1.2
1.63
1.59
g/l
0.19
14
168
12
97
1.24
0.23
4.7
3.9
8.33
8.53
kpa
0.21
12
97
25
219
1.15
0.22
3.7
3.9
5.12
5.16
kpa
0.09
25
214
0
11
0.00
0.21
0.0
1.0
—
3.12
—
0
5
0
11
0.00
0.21
0.0
1.1
—
0.01
—
0
5
26
293
0.88
0.21
2.7
3.6
1.23
1.23
mmol/l
0.03
20
241
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
144.45
—
0
13
6
48
1.25
0.20
1.2
1.5
0.13
0.18
nmol/l
—
6
32
17
147
1.16
0.18
5.0
2.0
1.71
1.41
g/l
0.67
17
131
7
59
1.19
0.18
2.1
2.3
16.54
16.25
%
—
7
59
7
61
1.15
0.17
1.3
1.4
—
—
—
0
0
21
186
1.14
0.17
1.3
1.3
—
—
—
0
0
34
311
1.10
0.17
2.4
2.8
0.63
0.89
ug/l
0.83
16
188
14
162
0.86
0.16
1.6
2.0
2.72
6.02
mg/l
—
8
125
8
72
1.11
0.16
1.5
1.5
—
—
—
0
0
22
197
1.12
0.15
3.0
3.7
1.26
1.88
mmol/l
0.43
13
152
45
420
1.08
0.15
1.8
1.9
—
—
—
0
0
54
513
1.06
0.12
4.4
5.1
1.87
2.55
ug/l
0.66
45
464
11
95
1.16
0.11
1.1
1.5
—
—
—
0
0
11
96
1.15
0.10
1.1
1.4
—
—
—
0
0
19
207
0.91
0.09
1.6
1.8
—
—
—
0
0
6
55
1.09
0.09
1.3
1.1
—
2.58
—
0
12
6
58
1.03
0.08
1.5
1.2
—
—
—
0
0
5
64
0.78
0.08
1.8
1.3
—
—
—
0
0
26
244
1.07
0.08
1.6
1.9
—
—
—
0
0
38
363
1.05
0.07
3.3
4.3
2.61
1.71
mmol/l
1.14
33
304
8
78
1.03
0.07
1.0
1.6
—
—
—
0
0
8
90
0.89
0.07
1.5
2.1
0.00
0.00
g/l
—
8
82
10
101
0.99
0.00
1.0
1.1
—
4.17
—
0
15
38
385
0.99
0.00
9.0
5.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.01
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
7.37
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
15.36
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.2
—
1.48
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
1.19
—
0
9
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
9.7
—
—
—
0
0
9
94
0.96
-0.00
1.2
1.3
—
3.85
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_VARUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VARUS | 0.983 [0.85, 1.14] | 0.816 |
| Birth year | 0.994 [0.99, 1.0] | 0.151 |
During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 2081 females with M13_VARUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VARUS | 0.887 [0.73, 1.08] | 0.242 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 763 males with M13_VARUS died.
Mortality risk
Mortality risk for people of age
years, who have M13_VARUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.182% |
| 5 | 0.453% | 1.075% |
| 10 | 1.299% | 2.474% |
| 15 | 2.626% | 4.632% |
| 20 | 4.587% | 7.824% |
Relationships between endpoints
↥Index endpoint: M13_VARUS – Varus deformity, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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