Temporal arteritis

M13_TEMPARTERIT

temporal arteritis: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M31.5
  • Cause of death: ICD-10 M31.5

2 out of 7 registries used, show all original rules.

1520

4. Check minimum number of events

None

1520

5. Include endpoints

None

1520

6. Filter based on genotype QC (FinnGen only)

1385

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M31
Name in latin
Arteritis gigantocellularis cum polymyalgia reumatica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7500 5041 2416
Only index persons 6755 4573 2182
Unadjusted period prevalence (%)
Whole population 0.12 0.14 0.07
Only index persons 0.14 0.17 0.08
Median age at first event (years)
Whole population 72.49 72.98 71.41
Only index persons 71.88 72.38 70.83

-FinnGen-

Key figures

All Female Male
Number of individuals 1385 858 527
Unadjusted period prevalence (%) 0.28 0.30 0.24
Median age at first event (years) 70.44 70.07 71.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1413
Matched controls
14130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
9.1
323.3
506
818
H02AB06
ATC
prednisolone; systemic
21.4
307.7
1308
5200
M35.3
ICD-10 Finland
Polymyalgia rheumatica
65.3
307.7
573
146
PAW37
NOMESCO Finland
Biopsy of temporal artery
1124.3
307.7
553
8
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
4503599627370496.0
307.7
1411
5
L04AX03
ATC
methotrexate; systemic
11.2
307.7
503
665
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.4
225.9
1063
4541
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.4
221.7
297
388
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
15.2
218.5
202
153
M31.6
ICD-10 Finland
Other giant cell arteritis
1175.5
212.1
202
*
M05BA04
ATC
alendronic acid; oral
6.1
208.2
465
1044
R51.80
ICD-10 Finland
Headache
4.9
153.3
441
1201
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.7
131.8
284
599
L88
ICPC
Rheumatoid/seropositive arthritis
7.6
112.8
171
252
I77.6
ICD-10 Finland
Arteritis, unspecified
198.6
107.0
110
6
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
97.0
92
*
A02BC02
ATC
pantoprazole; systemic
4.6
87.9
1239
8590
R50.9
ICD-10 Finland
Fever, unspecified
3.4
82.0
370
1326
L04AX01
ATC
azathioprine; systemic
7.0
79.8
127
196
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
8.9
71.8
92
110
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
70.6
966
6147
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
32.4
67.8
44
14
H02AB07
ATC
prednisone; oral
3.2
66.4
329
1233
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.1
57.6
176
479
L04AC07
ATC
tocilizumab; parenteral
104.4
55.3
60
6
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.8
52.0
99
182
TPX00
NOMESCO Finland
Biopsy of artery or vein
140.3
51.2
54
*
N01
ICPC
Headache
3.3
49.9
212
716
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.8
49.7
290
1175
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
16.9
48.9
41
25
A10AC01
ATC
insulin (human); parenteral
3.4
47.5
190
618
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
47.0
380
1806
M13.9
ICD-10 Finland
Arthritis, unspecified
3.6
46.8
169
514
G44.2
ICD-10 Finland
Tension-type headache
2.8
45.3
265
1071
H53.1
ICD-10 Finland
Subjective visual disturbances
3.5
44.7
171
540
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
440.7
43.4
43
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
41.7
280
1210
P01BA02
ATC
hydroxychloroquine; oral
3.3
41.7
170
558
L04AA13
ATC
[U] leflunomide
5.8
40.3
76
138
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.7
38.8
74
136
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.1
37.7
109
283
AA1AD
NOMESCO Finland
CT of head and brain
2.1
37.0
598
3710
M05BA07
ATC
risedronic acid; oral
3.9
36.9
116
320
M31.3
ICD-10 Finland
Wegener granulomatosis
366.3
36.1
36
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
35.1
551
3365
A01
ICPC
Pain general/multiple sites
2.6
34.5
236
1022
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
334.6
33.0
33
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
32.2
626
4089
H57.1
ICD-10 Finland
Ocular pain
4.2
31.9
89
225
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
31.8
227
1002
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
8.1
31.2
42
53
ZX120
NOMESCO Finland
Intravenous
2.6
30.7
195
812
M25.5
ICD-10 Finland
Pain in joint
2.0
30.6
499
3057
M05BX04
ATC
denosumab; parenteral
2.7
30.6
181
728
J01DB01
ATC
cefalexin; oral
2.4
30.4
1196
9885
L01BA01
ATC
methotrexate; systemic
4.0
29.7
87
228
M35.5
ICD-10 Finland
Multifocal fibrosclerosis
+∞
29.3
28
*
M79.6
ICD-10 Finland
Pain in limb
1.8
27.7
702
4920
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
26.8
759
5482
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
26.6
213
986
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
26.3
485
3062
R51
ICD-10 Finland
Headache
3.4
25.8
97
301
H34.1
ICD-10 Finland
Central retinal artery occlusion
9.3
25.7
31
34
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.5
24.7
168
721
UJF32
NOMESCO Finland
Coloscopy
1.9
24.6
466
2957
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
23.6
324
1845
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
23.5
329
1885
S18
ICPC
Laceration/cut
1.8
23.1
762
5659
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.4
23.0
171
763
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
22.8
383
2329
R52.9
ICD-10 Finland
Pain, unspecified
2.3
22.5
187
876
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
22.5
111
404
N02AX02
ATC
tramadol; systemic, rectal
1.7
22.3
676
4888
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
22.1
194
930
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.2
21.8
205
1010
N02BE01
ATC
paracetamol; systemic, rectal
2.7
21.7
1314
11720
R53
ICD-10 Finland
Malaise and fatigue
1.8
21.5
421
2678
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
21.3
624
4449
H15.1
ICD-10 Finland
Episcleritis
6.9
21.3
33
49
A02BC05
ATC
esomeprazole; systemic
1.7
21.1
627
4488
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.6
21.0
72
210
M79.1
ICD-10 Finland
Myalgia
2.1
21.0
238
1260
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.9
20.9
325
1920
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.3
20.8
82
262
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
20.4
360
2211
R06.0
ICD-10 Finland
Dyspnoea
1.7
20.4
478
3195
R51.81
ICD-10 Finland
Facial pain NOS
4.0
20.3
58
149
L95
ICPC
Osteoporosis
2.7
20.2
113
440
N03AX16
ATC
[U] pregabalin
1.8
19.9
377
2364
A03
ICPC
Fever
2.1
19.9
218
1138
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
19.4
546
3826
H53.2
ICD-10 Finland
Diplopia
3.2
19.0
75
240
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.5
18.8
130
560
N03AX12
ATC
[U] gabapentin; oral
1.9
18.8
274
1580
XCK00
NOMESCO Finland
Perimetry
2.4
18.5
132
577
TAB00
NOMESCO Finland
Lumbar puncture
3.1
18.4
78
260
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
18.4
483
3310
A10AB05
ATC
insulin aspart; parenteral
2.3
18.2
140
633
L04AA06
ATC
mycophenolic acid; systemic
5.5
18.1
35
65
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.3
18.0
144
662
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
17.8
693
5244
L28
ICPC
Limited function/disability (L)
1.7
17.7
382
2478
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.0
17.6
206
1099
R03AC02
ATC
salbutamol; inhalant
1.6
17.6
758
5872
M03BX02
ATC
tizanidine; oral
1.6
17.6
801
6290
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.5
17.3
113
474
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
17.3
302
1839
J01AA02
ATC
doxycycline; systemic
1.8
17.2
1108
9492
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
17.0
671
5072
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
16.7
16
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
16.7
252
1465
A02BC01
ATC
omeprazole; systemic
1.7
16.6
435
2964
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
6.8
16.6
26
39
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
91.2
16.6
18
*
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
16.5
223
1249
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.1
16.4
70
235
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.8
16.3
86
324
K07.63
ICD-10 Finland
Pain in the jaw joint UNS
4.6
16.2
38
84
A04
ICPC
Weakness/tiredness general
1.8
16.2
278
1682
J01FF01
ATC
clindamycin; systemic
1.7
16.1
395
2641
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.4
16.1
110
471
H25.1
ICD-10 Finland
Senile nuclear cataract
1.6
16.1
580
4273
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.2
16.1
153
755
R02
ICPC
Shortness of breath/dyspnoea
1.9
16.0
247
1446
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.0
15.9
183
969
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
15.9
143
690
J01MA02
ATC
ciprofloxacin; systemic
1.6
15.8
596
4431
J01FA10
ATC
azithromycin; systemic
1.6
15.8
705
5452
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
15.8
208
1154
C07AB07
ATC
bisoprolol; oral
1.6
15.7
834
6714
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
15.6
147
722
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
15.5
500
3576
J01MA14
ATC
moxifloxacin; systemic
2.1
15.5
153
765
J01CA04
ATC
amoxicillin; systemic
1.7
15.5
1096
9450
L17
ICPC
Foot/toe symptom/complaint
1.6
15.5
476
3366
M79.7
ICD-10 Finland
Fibromyalgia
3.3
15.3
58
181
A02BC03
ATC
lansoprazole; oral
1.6
15.3
450
3146
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.4
15.3
113
502
C03CA01
ATC
furosemide; systemic
1.6
15.3
593
4431
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.9
15.1
211
1195
R05
ICD-10 Finland
Cough
1.7
14.9
321
2068
L01
ICPC
Neck symptom/complaint
1.8
14.8
239
1416
N05CF01
ATC
zopiclone; oral
1.6
14.6
507
3679
E0000UV, ,
ATC
1.6
14.5
586
4405
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.0
14.4
159
828
PA6AD
NOMESCO Finland
CT of neck arteries
2.7
14.4
78
298
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
14.4
288
1815
M03BC01
ATC
orphenadrine (citrate); systemic
1.7
14.4
283
1776
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
14.3
215
1245
R42
ICD-10 Finland
Dizziness and giddiness
1.6
14.1
396
2726
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
14.1
380
2590
M54.5
ICD-10 Finland
Low back pain
1.6
13.9
504
3685
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
13.9
935
7838
R05
ICPC
Cough
1.6
13.8
363
2458
A46
ICD-10 Finland
Erysipelas
1.8
13.8
250
1531
M05BA06
ATC
ibandronic acid; systemic
3.0
13.7
60
204
JN4AD
NOMESCO Finland
Body CT examination
1.8
13.7
208
1206
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
13.6
462
3324
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
13.4
344
2311
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.0
13.4
150
785
SPAT1153
SPAT
Removal of sutures
1.6
13.4
497
3646
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.4
13.4
91
389
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
13.4
277
1760
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.8
13.2
66
242
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
13.1
254
1582
L03
ICPC
Low back symptom/complaint
1.6
13.1
414
2924
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.1
13.1
125
617
R01AD09
ATC
mometasone; nasal
1.5
13.0
556
4204
CS494
NOMESCO Finland
Other visual field testing
2.9
12.9
59
206
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
12.9
203
1190
J01FA06
ATC
roxithromycin; oral
1.5
12.9
563
4273
L08
ICPC
Shoulder symptom/complaint
1.6
12.9
345
2342
H02AB09
ATC
hydrocortisone; systemic
3.4
12.8
45
134
H53.4
ICD-10 Finland
Visual field defects
3.4
12.8
46
139
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.0
12.7
135
694
L18
ICPC
Muscle pain
2.6
12.6
73
289
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
3.8
12.6
38
102
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
12.5
12
*
F29
ICPC
Eye symptom/complaint other
1.9
12.5
165
915
M30.0
ICD-10 Finland
Polyarteritis nodosa
131.1
12.5
13
*
R20.2
ICD-10 Finland
Paraesthesia of skin
2.2
12.4
103
481
Z71.8
ICD-10 Finland
Other specified counselling
1.5
12.3
448
3259
B01AC04
ATC
clopidogrel; oral
1.6
12.3
305
2027
A07EC01
ATC
sulfasalazine; oral, rectal
2.1
12.3
118
584
L20
ICPC
Joint symptom/complaint NOS
2.7
12.3
66
252
R03BB04
ATC
tiotropium bromide; inhalant
1.9
12.2
176
1003
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
5.0
12.2
26
53
G50.1
ICD-10 Finland
Atypical facial pain
3.6
12.2
40
114
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.0
12.2
52
175
R60.0
ICD-10 Finland
Localized oedema
1.7
12.1
226
1391
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.1
12.1
122
614
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
12.1
89
395
R01AD08
ATC
fluticasone; nasal
1.6
12.0
346
2384
SPAT1263
SPAT
Sampling
1.5
12.0
590
4570
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.0
12.0
126
645
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
11.9
218
1335
R52.2
ICD-10 Finland
Other chronic pain
2.6
11.9
70
280
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
11.7
888
7493
G47.3
ICD-10 Finland
Sleep apnoea
1.6
11.6
292
1944
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
3.6
11.5
37
104
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.6
11.5
64
249
M31.1
ICD-10 Finland
Thrombotic microangiopathy
121.0
11.4
12
*
Z3231
NOMESCO Finland
Registered nurse
1.5
11.4
392
2810
H47.1
ICD-10 Finland
Papilloedema, unspecified
9.7
11.3
22
23
H02AB04
ATC
methylprednisolone; systemic
1.7
11.2
216
1340
H11.3
ICD-10 Finland
Conjunctival haemorrhage
2.4
11.2
81
356
R74
ICPC
Upper respiratory infection acute
1.6
11.2
334
2316
L99
ICPC
Musculoskeletal disease other
3.2
11.2
43
136
R01AD12
ATC
fluticasone furoate; nasal
1.6
11.1
343
2396
A11
ICPC
Chest pain NOS
1.9
11.1
156
882
B37.09
ICD-10 Finland
Unspecified candidal stomatitis
4.3
11.0
28
66
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
8.6
11.0
23
27
UJF92
NOMESCO Finland
Capsular endoscopy
3.4
11.0
39
117
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.8
11.0
166
960
J01MA12
ATC
levofloxacin; systemic
1.6
10.9
287
1929
S97
ICPC
Chronic ulcer skin
2.0
10.9
125
659
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.8
10.9
166
963
G45.3
ICD-10 Finland
Amaurosis fugax
3.0
10.8
48
165
5BA08, ,
NOMESCO Finland
8.3
10.8
23
28
L04AK01
ATC
leflunomide; oral
8.3
10.8
23
28
TNG10
NOMESCO Finland
Puncture of knee
4.3
10.8
27
63
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
10.8
280
1877
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
10.8
415
3041
J02AC01
ATC
fluconazole; systemic
1.5
10.8
484
3661
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
10.7
381
2744
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
5.6
10.7
20
36
XF402
NOMESCO Finland
ECG with work load test
1.8
10.7
178
1059
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
10.7
260
1715
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
10.6
595
4698
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.3
10.6
40
125
J05AB01
ATC
aciclovir; systemic
1.6
10.6
309
2130
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
2.7
10.5
55
207
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
10.5
270
1806
4AC07, ,
NOMESCO Finland
110.8
10.4
11
*
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
10.4
10
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
10.4
10
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.7
10.3
187
1139
PD5BD
NOMESCO Finland
Extensive CT of aorta
3.3
10.3
38
117
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
2.6
10.2
57
222
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
2.6
10.2
60
240
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
10.2
146
830
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
13.2
10.2
17
13
J31.0
ICD-10 Finland
Chronic rhinitis
2.0
10.1
109
563
R03DC03
ATC
montelukast; oral
1.7
10.1
210
1330
H26.3
ICD-10 Finland
Drug-induced cataract
8.5
10.1
21
25
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
10.0
250
1656
J01FA09
ATC
clarithromycin; systemic
1.5
10.0
383
2794
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
3.3
10.0
38
119
H92.0
ICD-10 Finland
Otalgia
2.2
10.0
83
387
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.4
10.0
35
104
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
9.9
181
1106
C08CA01
ATC
amlodipine; oral
1.4
9.9
649
5256
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
9.8
788
6612
WZC30
NOMESCO Finland
Teaching
1.6
9.8
243
1607
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.4
9.8
672
5480
JN6JR
NOMESCO Finland
Extensive PET-CT of whole body metabolism (crown to foot)
26.2
9.8
13
5
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.8
9.8
147
847
PD5AD
NOMESCO Finland
CT of aorta
2.8
9.8
50
186
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.0
9.7
109
571
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
7.4
9.7
22
30
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.2
9.7
82
386
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.4
9.7
68
296
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
2.0
9.6
106
552
R04.2
ICD-10 Finland
Haemoptysis
2.5
9.6
61
254
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
9.5
253
1701
B01AF02
ATC
apixaban; oral
1.6
9.5
258
1744
M10.9
ICD-10 Finland
Gout, unspecified
1.9
9.5
119
648
4AC0X, ,
NOMESCO Finland
+∞
9.4
9
*
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
9.4
9
*
J45.1
ICD-10 Finland
Nonallergic asthma
2.0
9.3
109
579
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.5
9.3
377
2778
WZA90
NOMESCO Finland
Other medical or dental certificate
1.5
9.3
297
2082
R55
ICD-10 Finland
Syncope and collapse
1.7
9.3
190
1197
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.8
9.2
145
847
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.6
9.2
54
216
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.4
9.2
550
4362
R03BA05
ATC
fluticasone; inhalant
1.6
9.2
237
1582
M13.0
ICD-10 Finland
Polyarthritis, unspecified
4.3
9.1
23
54
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.6
9.1
227
1502
R06AE07
ATC
cetirizine; oral
1.4
9.0
541
4288
M70.6
ICD-10 Finland
Trochanteric bursitis
1.6
9.0
223
1473
H26.4
ICD-10 Finland
After-cataract
1.6
9.0
213
1392
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.2
8.9
72
333
R03BA02
ATC
budesonide; inhalant
1.6
8.9
243
1643
D01
ICPC
Abdominal pain/cramps general
1.7
8.9
163
996
R01AD01
ATC
beclometasone; nasal
1.7
8.9
193
1234
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.6
8.9
211
1380
N06AX21
ATC
duloxetine; oral
1.7
8.9
161
981
N02BF01
ATC
gabapentin; oral
1.7
8.9
159
966
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.7
8.8
185
1171
318
Kela drug reimbursment
Teriparatide
4.9
8.8
19
39
Z3229
NOMESCO Finland
Other healthcare associate professional
1.8
8.8
131
753
SPAT1301
SPAT
No procedures
1.4
8.8
461
3563
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
1.9
8.8
105
563
G50.0
ICD-10 Finland
Trigeminal neuralgia
3.0
8.7
38
130
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.4
8.7
526
4169
B02.9
ICD-10 Finland
Zoster without complication
1.9
8.7
119
667
D07AD01
ATC
clobetasol; topical
1.6
8.6
233
1570
SPAT1310
SPAT
Counselling related to known health issue
1.4
8.6
434
3327
JN3AD
NOMESCO Finland
Abdominal CT examination
1.6
8.6
195
1260
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.0
8.6
96
503
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
3.3
8.5
32
100
Z01.2
ICD-10 Finland
Dental examination
1.4
8.5
548
4390
D07AC01
ATC
betamethasone; topical
1.4
8.4
489
3842
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
1.8
8.4
125
718
NF1AA
NOMESCO Finland
Hip X-ray examination
1.7
8.4
173
1090
J01CF05
ATC
flucloxacillin; systemic
1.9
8.4
100
535
R21
ICPC
Throat symptom/complaint
1.6
8.4
202
1325
L01AA01
ATC
cyclophosphamide; systemic
7.9
8.4
18
23
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.9
8.4
111
616
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
8.3
8
*
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
8.3
509
4034
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
8.3
407
3100
A07AA02
ATC
nystatin; oral
1.9
8.3
103
559
R63.4
ICD-10 Finland
Abnormal weight loss
2.1
8.3
73
350
M05BB03
ATC
alendronic acid and colecalciferol; oral
2.4
8.2
53
222
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.8
8.2
116
656
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
2.6
8.2
46
180
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
1.8
8.2
116
657
K07.60
ICD-10 Finland
Snapping jaw
2.4
8.2
54
229
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
3.0
8.2
36
124
JN4BD
NOMESCO Finland
Extensive body CT
1.7
8.2
167
1051
M01AE02
ATC
naproxen; oral, rectal
1.4
8.1
699
5858
N03
ICPC
Pain face
4.6
8.1
19
42
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.8
8.1
116
659
K02.1
ICD-10 Finland
Caries of dentine
1.4
8.1
675
5628
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
8.1
381
2879
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
8.1
386
2924
M03BC51
ATC
orphenadrine, combinations; systemic
1.5
8.0
327
2402
A02BA02
ATC
ranitidine; systemic
1.5
7.9
294
2121
H29
ICPC
Ear symptom/complaint other
1.6
7.9
186
1213
SPAT1260
SPAT
Consultation of another employee
1.5
7.9
249
1737
SFA20
NOMESCO Finland
Two-surface restoration
1.4
7.9
672
5616
A05AA02
ATC
ursodeoxycholic acid; oral
4.1
7.8
21
52
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
7.8
542
4378
XF600
NOMESCO Finland
Bloodpressure measurement
1.9
7.8
99
542
PG1AE
NOMESCO Finland
Ultrasound examination of artery not elsewher classified
7.0
7.8
18
26
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
3.7
7.8
24
66
L07
ICPC
Jaw symptom/complaint
4.2
7.7
20
48
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.9
7.7
90
478
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.0
7.7
85
443
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
7.7
337
2508
Z2221
NOMESCO Finland
Medical doctor
1.4
7.7
355
2668
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.5
7.7
280
2010
SFA30
NOMESCO Finland
Three-surface restoration
1.4
7.7
516
4142
H25.0
ICD-10 Finland
Senile incipient cataract
1.8
7.6
119
694
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
2.6
7.6
44
175
I35.0
ICD-10 Finland
Aortic (valve) stenosis
1.8
7.6
120
702
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
7.6
258
1825
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
8.1
7.6
16
20
XG410
NOMESCO Finland
Flow-volume spirometry
2.2
7.6
61
282
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.2
7.6
59
269
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
3.3
7.5
27
82
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
7.5
258
1829
NXL00
NOMESCO Finland
Biopsy of muscle
10.1
7.5
14
14
M48.0
ICD-10 Finland
Spinal stenosis
1.6
7.5
212
1443
R10.0
ICD-10 Finland
Acute abdomen
2.5
7.5
45
183
R07.3
ICD-10 Finland
Other chest pain
1.7
7.5
157
995
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.4
7.4
334
2497
207
Kela drug reimbursment
Chronic arrhythmias
1.5
7.4
290
2111
G43.9
ICD-10 Finland
Migraine, unspecified
2.3
7.4
52
227
4AC0L, ,
NOMESCO Finland
+∞
7.3
7
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
7.3
7
*
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
7.3
7
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.5
7.3
308
2275
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
7.3
296
2171
J20
ICD-10 Finland
Acute bronchitis
1.7
7.3
140
867
WZC00
NOMESCO Finland
Treatment plan or consultation
1.4
7.3
477
3807
C10AA05
ATC
atorvastatin; oral
1.4
7.3
657
5516
TGC00
NOMESCO Finland
Bronchial lavation
2.5
7.2
43
174
L29
ICPC
Musculoskeletal sympt/complt other
1.7
7.2
133
815
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
4.0
7.2
20
51
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.9
7.2
94
520
M05.2
ICD-10 Finland
Rheumatoid vasculitis
30.2
7.2
9
*
PA7BD
NOMESCO Finland
CT angiography of neck and brain
2.9
7.1
33
117
SFA10
NOMESCO Finland
One-surface restoration
1.4
7.1
650
5458
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.5
7.1
43
175
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.3
7.1
26
80
ZXA00
NOMESCO Finland
Right side
1.4
7.1
393
3045
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
2.1
7.1
69
344
C08CA05
ATC
nifedipine; systemic
1.9
7.1
95
529
R13
ICD-10 Finland
Dysphagia
1.8
7.1
112
656
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
2.2
7.1
57
264
B01AA03
ATC
warfarin; systemic
1.4
7.0
315
2350
GD1AD
NOMESCO Finland
Thorax CT examination
1.8
7.0
98
553
M01AH03
ATC
valdecoxib; oral
1.9
7.0
87
473
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
3.9
7.0
20
52
L60.0
ICD-10 Finland
Ingrowing nail
2.0
7.0
71
360
Z00.0
ICD-10 Finland
General medical examination
1.5
7.0
268
1942
K30
ICD-10 Finland
Functional dyspepsia
1.6
7.0
150
956
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
2.3
6.9
50
221
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
3.7
6.9
21
57
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
1.6
6.9
149
950
C01CA24
ATC
epinephrine; parenteral
2.1
6.9
67
334
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
3.6
6.9
22
62
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.8
6.9
104
602
SPAT1211
SPAT
Application of soft bandage
1.7
6.8
126
771
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
1.9
6.8
87
477
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.6
6.8
145
921
N06AX11
ATC
mirtazapine; oral
1.4
6.8
455
3633
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.5
6.8
190
1288
XF404
NOMESCO Finland
Ambulatory ECG
1.7
6.8
136
852
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.5
6.7
260
1885
J01DA01
ATC
[U] cefalexin
1.3
6.7
798
6947
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
3.5
6.7
22
63
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
2.3
6.7
49
218
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
1.9
6.7
82
444
PAA99
NOMESCO Finland
Exploration of other arterial branch originating from aortic arch arteries
22.6
6.7
9
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.7
6.7
127
784
J05AB11
ATC
valaciclovir; oral
1.5
6.7
197
1352
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.6
6.7
145
927
SDA03
NOMESCO Finland
Periodontal treatment
1.4
6.6
457
3664
H05AA02
ATC
teriparatide; parenteral
5.5
6.6
18
33
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
3.1
6.6
26
84
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
2.9
6.6
29
100
R83
ICPC
Respiratory infection other
1.5
6.6
218
1532
N06AA09
ATC
amitriptyline; systemic
1.6
6.6
145
929
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
1.9
6.6
80
432
XKD00
NOMESCO Finland
Uroflowmetry
1.5
6.6
216
1516
G44.8
ICD-10 Finland
Other specified headache syndromes
3.5
6.6
22
64
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
2.4
6.6
42
176
R11
ICD-10 Finland
Nausea and vomiting
1.7
6.6
129
803
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
1.8
6.5
93
528
F05
ICPC
Visual disturbance other
2.2
6.5
54
253
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
6.5
971
8725
J37.0
ICD-10 Finland
Chronic laryngitis
2.3
6.5
49
221
R01AD58
ATC
fluticasone, combinations; nasal
1.5
6.5
236
1691
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.9
6.5
78
420
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
3.1
6.5
26
85
M81.4
ICD-10 Finland
Drug-induced osteoporosis
6.2
6.5
16
26
I73.0
ICD-10 Finland
Raynaud syndrome
3.5
6.4
21
60
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
3.5
6.4
21
60
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
4.0
6.4
18
46
L19
ICPC
Muscle symptom/complaint NOS
2.4
6.4
43
184
AA1BD
NOMESCO Finland
Extensive CT of head and brain
2.4
6.4
43
184
XCK10
NOMESCO Finland
Photography of fundus of eye
1.6
6.4
147
951
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
70.2
6.4
7
*
SPAT1081
SPAT
Cardiorespiratory global assessment
1.8
6.4
91
518
K04.1
ICD-10 Finland
Necrosis of pulp
1.7
6.3
119
733
M94.0
ICD-10 Finland
Chondrocostal junction syndrome [Tietze]
2.6
6.3
35
137
UKC02
NOMESCO Finland
Cystoscopy
1.5
6.3
233
1674
ZXE00
NOMESCO Finland
One hour or less
1.3
6.3
493
4025
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.1
6.3
60
298
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.6
6.3
166
1112
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
6.3
6
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
6.3
6
*
K59.1
ICD-10 Finland
Functional diarrhoea
1.8
6.2
87
492
E000006, ,
ATC
1.8
6.2
94
545
E000002, ,
ATC
1.7
6.2
119
737
H34.2
ICD-10 Finland
Other retinal artery occlusions
5.1
6.2
18
36
M02AA07
ATC
piroxicam; topical
1.3
6.2
508
4175
M01AH01
ATC
celecoxib; oral
1.4
6.2
253
1854
I50.9
ICD-10 Finland
Heart failure, unspecified
1.4
6.2
260
1916
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.0
6.1
66
342
R23.3
ICD-10 Finland
Spontaneous ecchymoses
2.5
6.1
37
151
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
6.1
224
1607
R03BA01
ATC
beclometasone; inhalant
1.5
6.1
181
1244
R03BA08
ATC
ciclesonide; inhalant
1.7
6.1
105
632
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.1
6.1
24
78
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
2.5
6.1
36
146
NA1AD
NOMESCO Finland
Cervical spine CT examination
1.9
6.1
74
401
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
3.6
6.0
19
53
F01
ICPC
Eye pain
2.4
6.0
40
171

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
601
1398
6.74
266.17
1.6
1.3
640.88
395.77
titre
1.90
136
312
327
414
9.98
251.66
1.6
1.1
—
—
—
0
0
263
400
7.85
170.84
2.1
1.3
5.81
5.25
iu/ml
0.17
75
80
180
212
9.58
143.82
1.6
1.1
343.64
154.29
titre
0.60
22
14
1140
6404
5.04
140.80
13.5
5.6
0.04
0.04
e9/l
0.85
1038
5359
1138
6387
5.02
140.65
13.5
5.6
0.65
0.61
e9/l
6.36
1037
5333
1153
6592
5.07
137.46
13.7
5.8
0.16
0.19
e9/l
12.64
1061
5610
1143
6507
4.96
136.66
13.6
5.7
1.84
1.88
e9/l
0.41
1061
5593
538
1882
4.00
131.12
1.5
1.2
7.93
14.61
u/ml
1.60
183
648
554
1997
3.92
128.92
1.5
1.2
28.91
38.79
iu/ml
1.13
171
618
193
282
7.77
128.70
1.8
1.2
0.25
0.24
g/l
0.48
181
263
194
292
7.54
125.91
1.8
1.2
1.28
1.20
g/l
2.27
184
274
377
1073
4.43
121.12
1.7
2.8
—
—
—
0
0
1043
5929
3.90
115.60
13.9
5.9
8.52
9.11
%
8.47
1013
5482
1037
5924
3.82
112.86
14.1
5.9
0.58
0.66
%
5.07
1005
5477
1035
5921
3.80
112.02
13.9
5.9
2.05
2.80
%
31.28
1005
5476
1029
5886
3.75
110.90
13.7
5.8
62.31
58.35
%
21.43
1004
5568
1040
6016
3.76
109.50
13.8
5.9
23.99
26.17
%
9.20
1016
5645
849
4408
3.32
105.16
2.9
2.2
117.15
227.75
u/l
6.08
812
4138
1158
7291
4.26
104.76
16.0
9.3
5.05
4.20
e9/l
26.97
1062
6246
402
1339
3.80
101.98
1.8
3.0
65.20
66.07
g/l
1.41
366
1209
195
374
5.89
99.13
1.4
1.1
0.17
1.13
u/ml
0.81
15
28
1143
7379
3.87
93.73
9.1
7.1
1.22
1.21
mmol/l
1.25
1038
6355
365
1205
3.74
92.97
2.3
2.1
341.37
391.50
nmol/l
5.23
332
1102
1000
6061
3.22
88.59
3.4
2.4
81.99
80.04
nmol/l
1.37
938
5306
1051
6646
3.27
84.60
7.5
6.3
1.21
1.21
mmol/l
0.42
1017
6099
333
1106
3.63
83.23
1.4
1.5
—
—
—
0
0
344
1175
3.55
82.27
1.5
1.5
—
—
—
0
0
303
972
3.70
79.54
1.3
1.5
—
—
—
0
0
231
647
4.07
73.37
1.2
1.4
—
—
—
0
0
1267
9344
4.44
72.46
17.5
4.2
17.11
14.50
mm/h
6.20
1236
8609
281
919
3.57
71.07
2.6
2.9
10.03
11.06
g/l
2.90
259
831
223
648
3.90
66.98
1.6
2.7
8.70
7.45
g/l
14.21
200
576
222
647
3.88
66.37
1.6
2.7
3.88
3.73
g/l
0.71
199
576
222
648
3.88
66.22
1.6
2.7
4.19
4.20
g/l
0.08
199
577
212
601
3.97
65.90
1.7
2.7
3.74
2.95
g/l
13.30
188
530
202
560
4.04
64.73
1.6
2.7
9.51
10.49
g/l
2.08
176
485
231
712
3.68
63.50
2.7
2.6
16.08
22.22
au/ml
0.30
14
46
215
638
3.80
62.45
1.4
1.4
24.86
54.78
au/ml
—
10
46
734
4252
2.51
62.25
5.5
4.3
—
—
—
0
0
233
736
3.59
61.63
1.6
1.9
1.15
1.42
g/l
0.98
214
659
129
262
5.32
60.88
1.5
1.1
14.33
3.15
u/ml
1.06
20
27
128
261
5.29
60.13
1.5
1.1
7.85
3.02
u/ml
0.95
18
17
303
1151
3.08
59.14
8.1
3.7
0.49
0.65
%
1.13
148
359
753
4494
2.45
58.69
5.0
4.1
7.40
7.40
ph
1.50
600
3264
1005
6943
2.55
55.08
6.9
4.4
0.00
0.22
estimate
0.54
236
1415
990
6793
2.53
55.05
6.8
4.4
0.00
0.00
estimate
-0.00
242
1454
999
6887
2.54
54.92
6.9
4.4
7.61
2.32
estimate
0.30
250
1513
305
1223
2.91
53.58
8.8
3.8
0.93
0.92
%
0.05
147
392
293
1156
2.94
52.98
9.1
3.9
0.07
0.12
%
1.04
134
326
290
1155
2.90
51.41
9.9
4.0
0.02
0.08
%
1.14
130
301
480
2461
2.44
50.87
10.0
4.7
—
—
—
0
0
658
3892
2.29
49.83
2.9
2.4
3.01
2.99
mg/l
0.07
575
3309
200
661
3.36
48.75
2.9
2.2
0.00
1.36
estimate
0.50
66
185
1256
9975
3.33
47.64
15.1
8.3
73.14
81.28
u/l
10.91
1235
9378
313
1349
2.70
47.38
2.8
2.2
0.00
0.01
estimate
0.50
72
251
182
579
3.46
47.06
1.9
3.8
31.64
75.25
mg/l
1.42
149
505
182
581
3.45
46.80
1.9
3.8
38.82
59.04
mg/l
1.20
149
505
470
2476
2.35
46.02
2.8
2.6
11.00
12.01
umol/l
2.39
434
2293
125
313
4.28
45.52
1.8
2.0
11.22
12.57
mg/l
1.15
114
283
136
369
3.97
44.41
1.3
1.7
—
—
—
0
0
166
523
3.46
43.47
1.8
3.6
1.39
4.48
ratio
1.83
92
310
442
2322
2.31
43.08
2.7
2.5
2.24
2.28
g/l
0.93
403
2134
818
5489
2.16
43.03
5.5
3.9
6.44
6.30
ph
2.58
406
2971
822
5537
2.16
42.67
21.9
12.2
0.00
0.00
e9/l
0.22
705
4479
51
56
9.41
42.34
1.2
1.1
6.32
7.90
u/l
0.22
37
48
333
1556
2.49
42.16
4.2
3.1
4.80
4.92
e9/l
0.11
273
1294
417
2159
2.32
41.88
2.8
2.6
19.38
21.38
%
2.27
381
1999
84
166
5.32
40.68
1.5
1.7
0.79
0.83
g/l
0.08
63
129
370
1879
2.31
38.43
2.3
2.5
1.88
1.82
%
0.40
331
1660
1058
8044
2.25
38.08
6.4
5.0
6.74
6.83
mmol/l
0.73
1029
7677
811
5585
2.06
37.84
3.8
3.0
164.41
136.25
ug/l
1.58
750
5086
416
2236
2.22
37.55
1.6
1.5
2.36
2.59
g/l
1.87
282
1261
180
654
3.01
37.00
1.8
1.8
1.93
1.96
ug/l
0.01
152
571
56
84
6.90
35.85
1.4
1.1
185.00
67.50
titre
0.56
12
12
306
1473
2.38
35.68
2.3
2.6
70.84
68.77
e9/l
0.39
227
1096
700
4642
2.01
35.48
4.5
3.5
31.51
69.15
e6/l
1.71
580
3588
1120
8825
2.30
35.24
7.5
5.5
398.25
2511.43
e6/l
—
8
150
894
6475
2.04
35.09
5.7
4.9
33.72
34.86
g/l
7.84
846
6042
85
193
4.62
34.95
1.5
1.1
68.14
15.68
u/ml
—
7
16
749
5147
1.97
33.61
6.0
4.2
111.43
108.75
e6/l
0.03
579
3710
67
129
5.40
33.36
1.5
1.2
—
—
—
0
0
964
7244
2.04
33.22
6.5
6.6
10.30
11.76
umol/l
3.64
926
6893
621
4023
1.97
32.92
4.3
3.4
0.29
0.52
e6/l
3.17
499
3002
44
58
7.80
31.55
1.1
1.1
—
—
—
0
0
538
3380
1.96
30.65
3.0
2.9
337.50
350.11
umol/l
1.87
475
2889
53
90
6.08
30.10
1.2
1.5
6.19
6.98
g/l
0.60
40
64
53
90
6.08
30.10
1.2
1.5
2.71
2.73
g/l
0.02
41
65
53
90
6.08
30.10
1.2
1.5
0.32
0.42
g/l
1.01
41
64
117
375
3.31
29.57
1.5
1.4
—
—
—
0
0
599
3948
1.90
29.15
7.3
4.5
0.00
0.00
estimate
0.78
232
1331
40
52
7.89
29.01
1.1
1.0
—
—
—
0
0
638
4310
1.88
28.59
3.0
2.6
58.85
62.93
u/l
0.54
595
3958
41
56
7.51
28.51
1.1
1.1
—
—
—
0
0
52
93
5.77
28.00
1.2
1.5
—
—
—
0
0
63
139
4.70
26.81
1.2
1.0
—
—
—
0
0
94
280
3.53
26.62
1.2
1.2
3.73
3.85
mmol/l
0.58
86
266
86
243
3.70
26.35
1.0
1.0
—
—
—
0
0
265
1357
2.17
25.91
2.2
2.1
220.20
141.80
ug/g
1.21
212
1070
66
156
4.39
25.79
1.6
1.5
51.77
65.92
%
1.66
43
98
507
3270
1.86
25.58
3.5
2.7
4.58
5.63
e6/l
1.34
469
2979
715
5123
1.80
25.47
2.4
2.3
—
—
—
0
0
898
6893
1.83
25.34
22.5
18.0
1.32
1.32
inr
0.06
783
5764
99
320
3.25
24.64
1.3
1.2
480.38
558.37
mg/l
0.94
93
304
83
244
3.55
23.97
1.2
1.2
—
—
—
0
0
448
2833
1.85
23.72
3.7
3.0
496.88
523.06
mosm/kgh2o
2.21
393
2473
28
30
9.50
23.57
1.1
1.0
—
—
—
0
0
28
30
9.50
23.57
1.1
1.0
—
—
—
0
0
28
30
9.50
23.57
1.1
1.0
—
—
—
0
0
170
749
2.44
23.56
1.5
1.7
2.03
1.56
g/l
5.18
145
651
71
191
3.86
23.34
1.1
1.1
—
—
—
0
0
704
5115
1.75
23.08
3.3
3.6
2.34
2.36
mmol/l
2.80
625
4591
135
539
2.66
22.96
1.9
2.2
244.39
484.84
ug/l
1.24
121
514
853
6568
1.75
22.53
2.6
2.3
92.72
95.20
pmol/l
0.79
476
3360
53
119
4.59
22.09
1.2
1.1
—
—
—
0
0
564
3927
1.73
20.91
9.4
6.3
—
—
—
0
0
316
1861
1.90
20.49
1.4
1.3
—
—
—
0
0
689
5093
1.69
20.27
3.7
3.2
1602.57
1576.30
ng/l
0.05
624
4442
1315
11799
2.65
20.26
41.0
18.6
23.62
26.78
mg/l
3.74
1266
9961
737
5550
1.69
20.17
6.3
4.3
30.49
67.06
ng/l
1.92
605
4363
424
2760
1.77
19.72
2.0
1.6
1.39
1.51
mg/l
0.28
348
2177
51
122
4.30
19.64
1.2
1.1
—
—
—
0
0
354
2189
1.82
19.55
2.1
2.0
29.15
29.51
s
0.44
346
2117
396
2535
1.78
19.46
3.8
3.1
1.81
1.21
e6/l
0.31
248
1380
33
54
6.23
19.43
1.0
1.0
—
—
—
0
0
57
151
3.89
19.16
3.1
3.8
58.75
58.56
%
0.02
51
133
101
387
2.73
18.57
1.2
1.4
—
—
—
0
0
427
2832
1.73
18.35
2.0
1.8
1140.34
1181.03
nmol/l
0.40
319
2078
94
351
2.80
18.16
1.8
1.6
11936.57
17290.28
e6/l
0.85
74
254
663
4958
1.64
17.85
4.2
3.7
—
—
—
0
0
669
5044
1.62
17.21
7.0
4.5
0.49
0.51
estimate
0.01
212
1180
27
17
16.16
17.04
1.2
1.1
—
—
—
0
0
1102
9441
1.76
16.89
5.3
4.5
15.43
15.13
pmol/l
3.62
1021
8477
82
296
2.88
16.86
1.3
1.1
77.50
84.55
titre
—
8
22
41
94
4.46
16.68
1.4
1.9
—
—
—
0
0
69
230
3.10
16.32
1.2
1.2
—
—
—
0
0
605
4510
1.60
15.92
2.0
1.8
19.25
20.31
nmol/l
1.11
515
3716
492
3490
1.63
15.90
4.6
3.5
0.80
0.02
—
10
117
38
86
4.51
15.71
1.2
1.2
—
—
—
0
0
48
132
3.73
15.33
1.1
1.2
—
—
—
0
0
53
157
3.47
15.17
2.7
4.3
—
—
—
0
0
256
1542
1.81
15.01
2.1
1.8
—
—
—
0
0
243
1443
1.83
14.92
5.7
4.6
7.36
7.36
ph
0.00
207
1021
352
2327
1.68
14.82
4.0
3.2
4.22
2.57
e6/l
1.25
201
1162
62
207
3.09
14.64
4.0
2.8
5.19
4.43
e9/l
1.50
62
207
253
1531
1.79
14.57
1.7
1.4
—
—
—
0
0
219
1277
1.85
14.22
3.4
3.5
85.87
90.99
ng/l
0.33
195
1068
359
2420
1.65
13.90
2.8
3.0
0.81
0.81
mmol/l
0.20
332
2258
71
264
2.78
13.85
4.1
2.7
64.21
59.72
%
1.99
71
264
449
3206
1.59
13.69
2.9
3.1
2.47
2.47
mmol/l
0.36
400
2885
309
2013
1.68
13.61
2.2
2.0
—
—
—
0
0
208
1210
1.84
13.58
4.8
3.9
1.22
1.23
mmol/l
1.41
194
1029
226
1357
1.79
13.28
3.2
2.5
5.12
6.75
ug/l
1.44
189
1186
72
276
2.70
13.25
1.2
1.2
23.34
60.50
e6/l
0.56
50
208
475
3459
1.56
13.19
6.1
4.0
1.17
0.06
estimate
0.47
215
1129
227
1368
1.79
13.17
6.9
6.6
1.37
1.35
mmol/l
0.09
218
1351
72
278
2.68
13.07
1.2
1.3
1982.67
891.03
e6/l
0.26
54
220
24
43
5.66
12.91
1.2
1.1
45.00
63.89
ng/l
—
6
9
215
1300
1.77
12.29
2.6
2.3
30.54
37.18
u/l
2.39
178
1076
55
191
2.96
12.17
1.1
1.3
—
—
—
0
0
1230
11157
1.79
12.13
6.9
5.7
1.85
2.04
mu/l
5.55
1151
10096
51
171
3.06
12.00
1.2
1.2
300.43
296.95
u/ml
0.02
28
87
21
18
11.82
11.83
1.0
1.2
—
—
—
0
0
30
71
4.30
11.76
1.1
1.1
35.04
37.38
mg/l
0.15
25
64
298
1991
1.63
11.71
6.6
5.0
1.06
1.04
mmol/l
0.49
280
1818
217
1335
1.74
11.65
7.2
6.2
10.52
10.93
mmol/l
0.36
212
1279
402
2888
1.55
11.58
6.2
4.1
83.52
362.66
ng/l
7.32
350
2478
367
2590
1.56
11.42
1.4
1.3
1.47
1.44
u/ml
0.02
87
661
1249
11423
1.80
11.40
8.7
7.3
40.93
40.29
mmol/mol
1.84
1184
10479
143
779
1.93
11.38
2.6
2.5
—
—
—
0
0
40
123
3.32
10.86
1.4
1.2
—
—
—
0
0
243
1575
1.66
10.69
3.8
3.3
7.39
7.38
ph
1.55
141
925
232
1493
1.66
10.49
1.4
1.3
—
—
—
0
0
456
3435
1.48
10.25
4.9
4.2
88.68
86.26
%
1.25
447
3361
235
1527
1.65
10.21
3.9
3.3
1.97
1.83
mmol/l
0.25
214
1304
863
7342
1.45
10.14
4.1
3.3
51.92
53.54
u/l
0.25
810
6713
48
173
2.84
9.98
1.1
1.1
—
—
—
0
0
21
43
4.94
9.80
1.2
1.1
1898.76
1702.95
miu/ml
0.29
21
43
122
665
1.91
9.69
1.4
1.2
189.30
232.75
u/ml
0.29
112
610
37
117
3.22
9.63
1.4
1.4
36.41
30.49
%
0.36
22
71
204
1297
1.67
9.62
8.0
7.7
—
—
—
0
0
47
171
2.81
9.61
1.1
1.0
—
—
—
0
0
25
61
4.15
9.46
1.2
1.3
7.67
1.90
%
—
6
10
110
584
1.96
9.44
1.3
1.3
—
—
—
0
0
88
435
2.09
9.20
1.4
1.4
290.57
276.06
ug/g
0.24
46
265
237
1585
1.60
9.10
3.9
3.3
5.77
5.80
kpa
0.15
231
1546
216
1413
1.62
9.08
2.2
2.0
0.22
0.20
g/l
2.01
192
1310
45
168
2.73
8.79
1.2
1.3
159.17
161.67
au/ml
0.04
12
53
21
48
4.43
8.63
1.0
1.1
—
73.43
%
—
0
7
1312
12351
1.87
8.54
35.7
23.3
139.36
139.59
mmol/l
2.21
1304
12107
72
341
2.17
8.41
1.2
1.2
—
—
—
0
0
505
4000
1.41
8.28
3.1
3.2
30.01
34.06
u/l
1.92
469
3757
1051
9431
1.45
8.21
41.5
23.7
14.25
13.89
%
13.93
1044
9295
1311
12361
1.84
8.17
36.3
23.5
3.97
3.99
mmol/l
3.16
1300
12099
1308
12326
1.82
8.14
24.9
13.1
23.35
24.14
u/l
1.23
1292
11894
259
1813
1.52
8.07
7.3
6.8
7.43
7.42
ph
1.32
138
1004
149
915
1.70
7.97
1.3
1.2
—
—
—
0
0
259
1818
1.52
7.96
7.3
6.7
12.20
12.13
kpa
0.07
248
1744
259
1818
1.52
7.96
7.3
6.7
4.99
5.10
kpa
1.05
248
1742
42
162
2.64
7.74
1.1
1.1
—
—
—
0
0
234
1619
1.53
7.67
7.6
7.0
96.04
95.29
%
1.84
227
1563
56
249
2.30
7.64
1.9
1.5
—
—
—
0
0
159
1006
1.65
7.60
8.9
8.4
0.58
0.63
%
0.98
159
997
35
124
2.87
7.56
1.3
1.2
3.94
5.44
u/ml
0.35
16
57
221
1515
1.54
7.55
8.0
7.4
118.39
118.92
g/l
0.16
216
1478
1319
12498
1.83
7.52
43.7
25.7
84.54
80.33
umol/l
2.33
1310
12338
20
50
4.04
7.36
1.1
1.1
—
—
—
0
0
33
115
2.91
7.35
1.2
1.2
—
—
—
0
0
41
161
2.59
7.31
1.4
2.2
—
—
—
0
0
726
6194
1.35
7.21
3.1
2.9
—
—
estimate
—
0
0
90
491
1.89
7.17
5.2
3.9
7.41
7.41
ph
0.07
90
486
57
263
2.22
7.14
1.6
1.9
4.72
4.64
mmol/24h
0.05
50
224
21
56
3.79
7.09
1.0
1.1
—
—
—
0
0
1235
11537
1.56
7.06
6.1
5.5
4.48
4.50
mmol/l
0.41
1145
10494
253
1812
1.48
6.99
7.4
6.7
0.82
0.96
mmol/l
0.25
212
1491
93
517
1.86
6.99
4.0
3.9
24.80
25.08
mmol/l
0.43
84
473
1227
11456
1.54
6.92
6.1
5.4
1.54
1.48
mmol/l
4.13
1130
10335
219
1530
1.51
6.83
2.4
2.6
7.65
8.37
umol/l
0.22
198
1356
10
6
16.78
6.75
2.4
1.2
—
—
—
0
0
15
21
7.21
6.71
1.1
1.0
—
—
—
0
0
150
966
1.62
6.68
4.3
3.7
5.08
5.20
kpa
1.01
141
926
1184
10993
1.48
6.66
5.1
4.6
1.28
1.27
mmol/l
0.09
1073
9785
63
312
2.07
6.62
1.9
1.8
4.07
23.28
iu/l
0.49
18
120
160
1051
1.59
6.57
9.0
8.1
1.33
1.27
%
0.31
160
1040
19
50
3.84
6.54
1.3
1.1
0.62
0.48
ratio
—
8
34
1241
11645
1.54
6.51
6.8
5.8
5.92
6.07
mmol/l
3.35
1138
10424
78
421
1.90
6.44
1.7
1.6
25.34
21.70
u/ml
0.18
14
60
1320
12580
1.75
6.40
52.7
28.7
92.08
91.79
fl
1.45
1313
12410
1320
12580
1.75
6.40
52.9
28.8
262.77
245.59
e9/l
15.39
1309
12291
1320
12581
1.75
6.38
52.6
28.7
30.21
30.40
pg
3.45
1313
12411
1320
12581
1.75
6.38
52.8
28.8
4.29
4.36
e12/l
6.82
1305
12233
1320
12581
1.75
6.38
53.5
29.3
39.10
39.35
%
1.13
1313
12406
75
401
1.92
6.37
4.6
3.3
2.17
1.96
index
0.13
40
195
1320
12583
1.75
6.35
52.9
28.8
7.78
6.82
e9/l
43.87
1306
12239
1320
12584
1.74
6.34
53.2
29.0
128.61
131.55
g/l
12.45
1313
12419
25
82
3.09
6.21
1.2
1.2
—
—
—
0
0
144
938
1.60
6.13
8.5
7.2
24.83
24.94
mmol/l
0.13
144
933
144
941
1.59
6.05
4.4
3.7
7.42
7.42
ph
0.24
126
790
188
1307
1.51
5.98
3.5
3.0
204.17
224.53
ng/l
0.29
171
1204
192
1342
1.50
5.95
3.3
2.8
4.43
4.39
kpa
0.08
186
1308
104
630
1.70
5.88
1.3
1.2
—
—
—
0
0
25
85
2.98
5.86
2.5
2.4
43.00
48.86
iu/ml
—
6
14
100
600
1.72
5.85
2.9
2.7
—
—
—
0
0
33
131
2.56
5.81
1.5
1.3
19811.05
174622.97
e6/l
1.26
20
90
114
711
1.66
5.78
3.0
3.3
4.37
4.37
pmol/l
0.01
95
619
41
181
2.30
5.75
2.0
2.3
0.71
1.16
g/24h
1.03
21
98
175
1212
1.51
5.67
3.0
2.4
0.23
0.58
e6/l
2.80
165
1158
108
668
1.67
5.66
4.4
3.8
—
—
—
0
0
26
94
2.80
5.48
2.2
2.2
—
—
—
0
0
78
446
1.79
5.41
1.7
1.9
21.91
21.32
s
0.18
70
410
85
501
1.74
5.32
2.1
3.0
943.76
433.32
mg/l
0.34
37
190
1246
11800
1.47
5.21
7.1
6.4
2.48
2.56
mmol/l
2.96
1153
10685
16
44
3.67
5.21
1.4
1.1
—
—
—
0
0
20
64
3.16
5.20
2.5
2.0
155.25
218.55
e6/l
0.93
20
56
592
5067
1.29
5.10
2.1
2.0
1.30
1.30
mmol/l
0.01
488
4126
23
81
2.87
5.10
2.0
1.7
48.22
37.01
%
2.24
23
81
37
166
2.26
5.04
1.4
1.4
—
—
—
0
0
37
166
2.26
5.04
1.4
1.4
—
—
—
0
0
37
166
2.26
5.04
1.4
1.4
—
—
—
0
0
37
166
2.26
5.04
1.4
1.4
—
—
—
0
0
387
3133
1.32
5.03
1.9
1.8
21519483.43
21352750.60
pmol/l
0.00
316
2529
32
137
2.37
4.85
1.2
1.2
—
—
—
0
0
46
230
2.03
4.79
3.5
2.2
1.16
0.87
%
1.01
36
164
416
3437
1.30
4.60
2.8
2.5
—
—
—
0
0
54
292
1.88
4.51
6.0
4.8
2.28
2.70
mmol/l
0.57
41
203
528
4509
1.27
4.48
2.9
2.6
—
—
—
0
0
54
293
1.88
4.47
6.0
4.8
8.56
8.38
kpa
0.31
54
288
54
293
1.88
4.47
6.0
4.8
4.97
5.09
kpa
0.67
54
288
567
4887
1.27
4.44
3.5
3.3
6.81
6.86
mmol/l
0.11
471
4044
374
3068
1.30
4.33
7.6
4.7
8.37
1.02
kg/l
0.80
275
2076
126
866
1.50
4.26
9.9
8.6
15.87
15.62
%
0.49
120
831
34
160
2.15
4.17
1.4
1.2
0.22
0.20
nmol/l
0.53
23
130
143
1019
1.45
4.04
6.4
4.5
—
—
—
0
0
13
31
4.22
4.01
1.6
1.2
43.43
17.60
%
—
7
20
10
18
5.59
3.97
1.0
1.1
—
—
—
0
0
140
999
1.45
3.93
4.0
2.9
127.55
126.56
g/l
0.23
134
972
70
433
1.65
3.75
4.3
3.6
0.83
0.81
nmol/l
0.12
56
357
555
4841
1.24
3.75
3.6
3.4
75.20
43.23
mg/l
1.49
358
3042
14
39
3.62
3.70
2.4
1.5
21.86
33.23
%
1.62
14
39
107
733
1.50
3.70
4.3
3.2
25.27
25.29
mmol/l
0.02
101
711
78
500
1.59
3.63
1.1
1.1
—
168.83
—
0
12
26
117
2.25
3.59
1.1
1.2
—
—
—
0
0
96
652
1.51
3.47
1.1
1.2
147.74
125.95
u/ml
0.18
26
226
53
311
1.73
3.47
5.3
4.1
—
—
—
0
0
32
159
2.04
3.46
1.4
1.2
—
—
nmol/l
—
0
0
117
831
1.44
3.39
1.3
1.3
—
—
—
0
0
46
261
1.79
3.38
1.1
1.2
—
—
—
0
0
18
71
2.56
3.30
1.4
1.5
—
—
—
0
0
35
184
1.93
3.26
1.3
1.3
32.76
33.15
iu/l
0.02
29
155
219
1737
1.31
3.21
5.6
5.4
34.31
33.65
%
0.36
162
1091
39
215
1.84
3.16
4.5
2.6
—
—
—
0
0
46
267
1.75
3.15
1.9
1.6
—
—
—
0
0
10
25
4.02
3.08
1.2
1.6
—
—
—
0
0
29
146
2.01
3.06
1.5
1.5
24.77
33.10
ng/l
0.35
29
146
9
21
4.31
2.99
1.2
1.0
—
—
—
0
0
557
4953
1.21
2.93
4.3
4.1
13.89
8.20
mg/mmol
1.34
356
3012
29
149
1.97
2.91
1.2
1.3
509.68
293.52
pmol/l
0.65
22
131
21
95
2.23
2.90
1.4
1.4
1655.29
1643.21
ml
0.03
21
90
6
9
6.69
2.87
1.0
1.2
—
—
—
0
0
30
157
1.93
2.86
3.3
3.1
14.95
11.83
index
0.78
20
77
14
53
2.66
2.80
8.2
4.0
—
—
—
0
0
8
18
4.46
2.79
1.0
1.0
—
—
—
0
0
77
529
1.48
2.69
4.3
3.6
1.27
1.41
mmol/l
0.87
77
519
36
206
1.77
2.63
2.5
2.6
—
—
—
0
0
10
30
3.35
2.60
1.4
1.3
—
183.00
—
0
6
5
7
7.16
2.55
2.4
1.1
—
—
—
0
0
5
7
7.16
2.55
1.8
1.4
—
—
—
0
0
56
367
1.55
2.46
3.3
2.6
1.93
1.68
mg/l
1.17
47
323
52
335
1.57
2.46
1.5
1.3
59.95
59.87
mmol/l
0.01
42
274
14
57
2.47
2.45
8.2
3.8
—
—
—
0
0
10
32
3.14
2.43
1.2
2.5
—
—
—
0
0
128
982
1.33
2.40
7.0
6.2
24.23
24.40
mmol/l
0.21
123
935
6
12
5.02
2.40
1.0
1.0
—
—
—
0
0
7
17
4.13
2.36
1.0
2.4
1.29
2.06
%
—
7
17
10
33
3.04
2.36
1.0
1.1
—
17.00
%
—
0
5
49
315
1.58
2.35
3.2
2.7
15.89
15.86
%
0.03
49
307
64
439
1.48
2.29
4.5
3.9
3.99
3.91
mmol/l
0.57
64
433
27
148
1.84
2.29
1.0
1.1
1.54
1.56
g/l
0.10
22
133
11
40
2.76
2.27
1.1
1.3
—
—
—
0
0
135
1053
1.31
2.27
3.3
3.1
5.96
6.05
ph
0.77
89
753
30
171
1.77
2.25
1.1
1.2
11.47
10.51
u/l
0.16
22
130
72
509
1.44
2.22
3.3
2.9
24.24
25.22
mmol/l
1.39
72
500
40
249
1.62
2.20
2.6
1.8
1.68
1.63
mmol/l
0.11
40
239
213
1769
1.24
2.16
1.3
1.4
—
—
—
0
0
204
1687
1.24
2.15
3.0
4.2
17.67
21.89
ug/l
0.13
168
1389
6
14
4.30
2.15
1.8
1.6
—
—
—
0
0
7
19
3.70
2.15
9.0
7.1
5.74
5.39
kpa
—
7
19
129
1010
1.31
2.12
1.6
1.6
—
—
—
0
0
71
506
1.42
2.11
1.4
1.3
—
—
—
0
0
102
775
1.34
2.07
3.9
4.0
1.01
1.02
ratio
2.84
93
711
5
10
5.01
2.07
1.2
1.1
—
—
—
0
0
0
56
0.00
2.06
0.0
1.1
—
5.58
—
0
26
23
125
1.85
2.03
1.2
1.4
—
—
—
0
0
16
76
2.12
2.03
1.4
1.3
31.97
34.70
u/l
0.14
11
64
9
32
2.82
2.00
1.4
1.8
—
—
—
0
0
21
112
1.89
1.96
1.0
1.1
3.50
2.65
eliau/ml
—
5
38
5
11
4.56
1.94
1.0
1.0
—
—
—
0
0
6
16
3.76
1.93
1.8
1.4
34.67
46.75
umol/l
—
6
16
45
299
1.52
1.92
2.0
2.5
27.00
34.65
umol/l
1.86
38
259
5
12
4.18
1.82
1.6
1.5
—
—
—
0
0
19
101
1.89
1.81
1.2
1.2
—
—
—
0
0
26
421
0.61
1.74
1.2
1.4
—
—
—
0
0
5
13
3.86
1.71
1.0
1.0
—
10.80
—
0
5
59
427
1.40
1.66
5.2
5.6
1.30
1.33
mmol/l
0.09
49
373
416
3754
1.15
1.66
6.2
6.2
4.76
3.15
ug/l
0.33
367
3340
8
31
2.59
1.66
1.1
1.2
—
—
—
0
0
27
166
1.64
1.62
3.1
2.7
—
—
—
0
0
5
14
3.58
1.61
1.8
1.2
—
—
—
0
0
5
14
3.58
1.61
14.2
13.4
4.66
5.35
mmol/l
—
5
14
5
14
3.58
1.61
1.8
1.2
—
—
—
0
0
5
14
3.58
1.61
1.8
1.2
—
—
—
0
0
20
113
1.78
1.61
1.1
1.1
99.20
103.52
pmol/l
0.19
20
113
24
147
1.64
1.48
1.2
1.3
—
—
—
0
0
8
168
0.47
1.47
1.0
1.1
—
—
—
0
0
92
732
1.27
1.41
2.0
2.0
—
—
—
0
0
44
315
1.41
1.36
3.6
3.0
89.59
89.10
%
0.19
44
301
5
17
2.95
1.36
1.8
1.1
88.02
180.77
ng/l
—
5
12
9
43
2.10
1.30
1.6
1.1
—
—
—
0
0
13
69
1.89
1.28
2.0
1.8
37.79
39.81
g/l
0.81
13
69
5
18
2.78
1.28
1.0
1.1
—
—
—
0
0
11
55
2.01
1.27
1.5
1.2
—
—
—
0
0
92
744
1.25
1.26
2.0
2.3
13.89
12.63
nmol/l
0.74
78
650
6
25
2.41
1.24
1.0
1.4
—
—
—
0
0
27
180
1.51
1.21
1.1
1.3
—
—
—
0
0
13
71
1.84
1.19
1.8
2.7
34.20
38.66
%
—
5
39
15
86
1.75
1.19
3.7
3.0
—
—
—
0
0
149
1280
1.18
1.14
1.3
1.4
—
—
—
0
0
27
187
1.45
1.04
1.7
1.7
—
—
—
0
0
24
163
1.48
1.02
3.6
2.1
-0.98
0.68
mmol/l
1.12
24
158
248
2236
1.13
1.01
3.8
3.5
0.66
0.80
ug/l
3.17
184
1567
15
91
1.66
1.00
1.9
1.8
14.75
16.26
%
1.13
15
91
9
48
1.88
1.00
2.6
2.4
—
—
—
0
0
26
181
1.44
0.98
1.5
1.5
—
—
—
0
0
11
61
1.81
0.98
1.1
1.4
7.48
5.95
umol/l
—
6
39
5
23
2.18
0.98
1.0
1.1
—
—
—
0
0
7
36
1.95
0.97
31.6
27.6
6.24
6.62
ug/l
—
7
30
47
364
1.30
0.95
3.5
3.0
8.02
7.85
kpa
0.31
47
351
40
303
1.33
0.94
6.3
6.2
103.40
105.25
mmol/l
1.50
35
272
40
303
1.33
0.94
6.3
6.2
11.26
11.21
mmol/l
0.04
35
272
8
43
1.87
0.87
1.4
2.2
—
—
—
0
0
79
660
1.21
0.86
5.3
4.5
0.84
0.87
%
0.30
74
623
46
362
1.28
0.85
2.3
2.3
129.30
125.43
g/l
0.69
37
288
13
80
1.63
0.84
1.1
1.2
—
—
—
0
0
11
65
1.70
0.82
1.0
1.0
—
—
—
0
0
72
600
1.21
0.81
2.7
3.4
62.22
2670.73
u/ml
0.95
58
524
85
722
1.19
0.79
5.1
4.3
1.43
1.51
%
0.49
80
685
0
27
0.00
0.77
0.0
6.1
—
8.47
—
0
27
0
27
0.00
0.77
0.0
1.1
—
2.32
—
0
11
349
3261
1.09
0.75
1.4
1.3
—
—
—
0
0
9
54
1.67
0.74
1.1
1.2
—
—
—
0
0
7
38
1.85
0.73
1.9
2.1
0.61
0.60
mmol/l
—
7
38
46
375
1.23
0.67
1.3
1.6
0.38
0.33
mg/l
0.23
24
155
7
43
1.63
0.67
2.9
1.9
0.00
0.00
estimate
—
7
43
41
331
1.25
0.65
1.3
1.1
—
—
—
0
0
5
29
1.73
0.64
3.0
1.3
—
—
—
0
0
14
97
1.45
0.59
1.4
1.6
88.79
102.99
ng/l
0.42
14
97
23
175
1.32
0.58
1.2
1.3
280.17
273.97
mosm/kgh2o
0.56
18
125
14
100
1.40
0.52
1.1
1.2
—
—
—
0
0
6
41
1.47
0.50
2.2
2.1
17.72
19.52
ug/l
—
6
35
14
101
1.39
0.49
1.1
1.2
—
—
—
0
0
14
101
1.39
0.49
1.1
1.2
—
—
—
0
0
39
326
1.20
0.49
2.1
2.4
238.50
78.05
ug/min
0.39
21
186
40
336
1.20
0.48
3.4
3.2
205.49
1203.84
u/ml
0.70
35
310
5
32
1.56
0.42
1.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
2.1
—
0.59
—
0
17
5
35
1.43
0.39
1.0
1.3
59.02
43.34
mu/l
—
5
26
5
36
1.39
0.38
1.4
1.6
76.40
846.64
nmol/24h
—
5
36
16
125
1.28
0.37
1.6
2.3
0.44
1.48
u/field
—
9
63
23
276
0.83
0.34
3.3
3.9
27.43
43.20
u/ml
0.91
23
270
13
100
1.30
0.33
1.7
1.8
—
—
—
0
0
13
100
1.30
0.33
1.1
1.2
—
—
—
0
0
7
97
0.72
0.31
1.7
1.2
—
—
—
0
0
34
385
0.88
0.27
1.5
1.3
—
—
—
0
0
12
95
1.27
0.26
1.1
1.2
—
—
—
0
0
5
71
0.70
0.26
1.2
1.2
200.20
135.67
nmol/l
—
5
71
13
106
1.23
0.23
1.6
1.7
7.88
8.65
mmol/l
0.31
13
106
23
264
0.87
0.23
2.0
1.6
—
—
—
0
0
5
41
1.22
0.22
1.0
1.4
164.20
159.80
mmol/24h
—
5
41
0
11
0.00
0.21
0.0
1.3
—
51.67
—
0
6
0
11
0.00
0.21
0.0
1.3
—
0.03
—
0
6
41
450
0.91
0.21
1.6
1.8
3.06
3.45
mmol/l
0.91
24
341
0
12
0.00
0.21
0.0
1.6
—
1.40
—
0
7
5
43
1.16
0.21
1.2
1.3
136.80
138.85
mmol/l
—
5
33
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
357
3652
0.97
0.18
3.4
3.6
—
—
—
0
0
9
80
1.13
0.15
1.3
1.5
—
—
—
0
0
12
103
1.17
0.13
2.3
1.3
—
—
—
0
0
12
103
1.17
0.13
1.7
1.1
—
—
—
0
0
119
1152
1.04
0.12
1.4
1.5
—
—
—
0
0
14
157
0.89
0.11
1.1
1.2
1.41
1.58
g/l
2.09
14
157
14
157
0.89
0.11
1.9
1.5
8.41
10.34
%
1.24
14
157
12
105
1.14
0.11
1.7
1.1
—
—
—
0
0
13
146
0.89
0.10
1.4
1.2
—
—
—
0
0
6
55
1.09
0.09
1.2
1.5
3.63
2.99
mmol/l
—
6
48
19
175
1.09
0.08
1.2
1.3
0.85
0.92
g/l
0.59
19
175
13
143
0.91
0.07
1.5
1.7
—
—
—
0
0
16
147
1.09
0.07
1.9
2.2
—
—
—
0
0
28
265
1.06
0.07
1.0
1.2
29.17
39.97
u/l
0.55
23
225
33
346
0.95
0.06
1.2
1.1
—
—
—
0
0
16
170
0.94
0.04
3.2
5.1
264.64
347.64
umol/l
1.35
11
152
20
191
1.05
0.03
1.3
1.4
5905.92
65427.21
e6/l
1.08
13
105
39
400
0.97
0.02
32.0
11.7
—
—
—
0
0
19
182
1.04
0.02
1.3
1.4
—
—
—
0
0
10
93
1.08
0.02
1.3
2.6
6.75
7.34
mmol/l
—
10
58
27
264
1.02
0.00
1.1
1.2
—
—
—
0
0
11
106
1.04
0.00
1.1
1.1
—
—
—
0
0
12
124
0.97
0.00
1.1
1.0
—
—
—
0
0
25
251
1.00
0.00
1.3
1.4
0.94
0.85
nmol/l
0.29
13
204
41
409
1.00
0.00
5.2
5.0
—
—
—
0
0
10
103
0.97
0.00
2.2
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
722.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.6
—
0.16
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
33.00
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
363.75
—
0
8
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
173.29
—
0
7
7
69
1.01
-0.00
1.3
1.7
77.14
86.75
umol/l
—
7
69
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_TEMPARTERIT and mortality.

Females

Parameter HR [95% CI] p-value
M13_TEMPARTERIT 1.308 [1.18, 1.44] < 0.001
Birth year 0.993 [0.99, 1.0] 0.119

During the follow-up period (1.1.1998 — 31.12.2019), 1563 out of 4350 females with M13_TEMPARTERIT died.

Males

Parameter HR [95% CI] p-value
M13_TEMPARTERIT 1.385 [1.19, 1.61] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 789 out of 2033 males with M13_TEMPARTERIT died.

Mortality risk

Mortality risk for people of age

years, who have M13_TEMPARTERIT.

N-year risk Females Males
1 0.127% 0.275%
5 0.736% 1.533%
10 1.731% 3.506%
15 3.541% 6.783%
20 6.176% 11.54%

Relationships between endpoints

Index endpoint: M13_TEMPARTERIT – Temporal arteritis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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