No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
408 |
4. Check minimum number of eventsNone |
408 |
5. Include endpointsNone |
408 |
6. Filter based on genotype QC (FinnGen only) |
373 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M67
- Name in latin
- Hypertrophia membranae synovialis non alibi classificata
Similar endpoints
↥List of similar endpoints to
Synovial hypertrophy, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Disorders of synovium and tendon
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3056 | 1552 | 1498 |
| Only index persons | 3008 | 1538 | 1470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 36.05 | 35.31 | 36.81 |
| Only index persons | 36.00 | 35.29 | 36.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 373 | 220 | 153 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.07 |
| Median age at first event (years) | 38.77 | 36.66 | 41.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 382
- Matched controls
- 3820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
169.5
320.2
159
16
M67.2
ICD-10 Finland
Synovial hypertrophy, not elsewhere classified
+∞
307.7
382
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
17.0
108.4
100
78
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
57.4
87.6
50
10
M22.4
ICD-10 Finland
Chondromalacia patellae
17.6
69.7
60
40
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
7.8
65.4
110
189
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
11.0
56.2
65
70
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
7.3
55.4
95
165
M17.1
ICD-10 Finland
Other primary gonarthrosis
4.7
38.1
110
301
M25.5
ICD-10 Finland
Pain in joint
3.7
35.1
182
750
M79.6
ICD-10 Finland
Pain in limb
3.5
32.6
195
872
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.2
31.9
106
319
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
5.9
26.4
51
97
S83.2
ICD-10 Finland
Tear of meniscus, current
5.5
25.9
55
114
M19.0
ICD-10 Finland
Primary arthrosis of other joints
5.6
25.7
53
107
M01AX05
ATC
glucosamine; oral
4.2
25.2
79
225
M23.8
ICD-10 Finland
Other internal derangements of knee
7.2
25.2
39
59
N03AX12
ATC
[U] gabapentin; oral
4.2
24.9
77
217
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.0
24.5
199
1019
M01AH05
ATC
etoricoxib; oral
3.3
24.1
283
1771
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
9.9
22.9
27
29
N02AX02
ATC
tramadol; systemic, rectal
2.9
22.7
174
856
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
25.8
22.5
31
13
M67.4
ICD-10 Finland
Ganglion
6.9
21.8
35
55
M01AH01
ATC
celecoxib; oral
3.6
20.4
77
248
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
4.0
20.1
63
178
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
20.1
191
1033
M01AX17
ATC
nimesulide; oral
3.2
19.1
93
350
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.7
19.1
47
110
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.8
18.6
65
198
M13.9
ICD-10 Finland
Arthritis, unspecified
5.1
18.5
41
88
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
15.4
18.4
30
21
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.9
16.9
55
159
M01AC06
ATC
meloxicam; systemic, rectal
2.6
16.4
139
696
N03AX16
ATC
[U] pregabalin
2.9
16.3
91
368
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
7.6
15.8
23
32
WX320
NOMESCO Finland
Spinalanesthesy
2.7
15.5
105
470
M01AB05
ATC
diclofenac; systemic, rectal
2.5
15.2
271
1877
M01AE02
ATC
naproxen; oral, rectal
2.4
15.1
238
1557
H02AB06
ATC
prednisolone; systemic
2.3
14.8
183
1076
L15
ICPC
Knee symptom/complaint
2.6
14.7
112
529
S18
ICPC
Laceration/cut
2.3
14.4
186
1111
M54.5
ICD-10 Finland
Low back pain
2.3
13.6
151
842
ACC51
NOMESCO Finland
Release of median nerve
4.5
13.5
34
81
M01AH02
ATC
rofecoxib; oral
3.6
13.4
47
143
M02AA07
ATC
piroxicam; topical
2.4
13.2
128
672
M48.0
ICD-10 Finland
Spinal stenosis
3.8
13.1
42
120
M67.8
ICD-10 Finland
Other specified disorders of synovium and tendon
29.5
13.1
17
6
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
72.3
12.7
14
*
L03
ICPC
Low back symptom/complaint
2.3
12.6
125
659
L08
ICPC
Shoulder symptom/complaint
2.6
12.4
87
392
M03BX02
ATC
tizanidine; oral
2.3
12.4
257
1822
M77.1
ICD-10 Finland
Lateral epicondylitis
3.8
12.3
40
115
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
11.7
119
632
1220
FHL
Arthroscopy
5.2
11.4
24
49
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.8
11.3
36
102
N02BF01
ATC
gabapentin; oral
3.3
11.0
43
140
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
4.4
10.8
28
68
R03AC02
ATC
salbutamol; inhalant
2.1
10.6
221
1529
L17
ICPC
Foot/toe symptom/complaint
2.2
10.6
116
631
S80.0
ICD-10 Finland
Contusion of knee
3.3
10.4
42
139
M79.1
ICD-10 Finland
Myalgia
2.7
10.4
63
263
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
4.3
10.3
27
66
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
10.3
85
410
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.7
10.3
59
239
A02BC05
ATC
esomeprazole; systemic
2.1
10.3
150
910
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
10.2
145
870
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.3
10.2
94
476
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
10.1
106
567
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
41.2
10.0
12
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.2
9.9
27
68
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.9
9.9
51
195
ZXE00
NOMESCO Finland
One hour or less
2.0
9.8
153
948
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
9.7
129
753
R20.2
ICD-10 Finland
Paraesthesia of skin
3.5
9.7
34
103
M70.6
ICD-10 Finland
Trochanteric bursitis
3.1
9.6
42
146
ZXA00
NOMESCO Finland
Right side
2.3
9.6
87
436
M03BC01
ATC
orphenadrine (citrate); systemic
2.2
9.5
98
519
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
4.7
9.4
22
49
WX110
NOMESCO Finland
Infiltration anesthesia
2.2
9.4
293
2302
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
4.6
9.2
22
50
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
9.2
132
790
X58
ICD-10 Finland
Exposure to other specified factors
2.5
9.1
66
299
P01BA02
ATC
hydroxychloroquine; oral
3.5
9.1
32
97
M01AB55
ATC
diclofenac, combinations; oral
4.4
9.0
23
55
S43.4
ICD-10 Finland
Sprain and strain of shoulder joint
4.1
9.0
25
64
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
19.2
9.0
13
7
ZXA05
NOMESCO Finland
Left side
2.3
8.9
78
384
ZXD20
NOMESCO Finland
Day surgery
2.7
8.9
52
212
J01AA02
ATC
doxycycline; systemic
2.1
8.9
287
2256
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.2
8.7
36
121
NGE15
NOMESCO Finland
Incision fo capsule of knee joint, arthroscopic
51.2
8.7
10
*
M02AA10
ATC
ketoprofen; topical
2.5
8.6
59
260
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
16.8
8.6
13
8
M54.4
ICD-10 Finland
Lumbago with sciatica
2.3
8.6
71
341
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.2
8.6
35
117
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.9
8.5
186
1277
NGF10
NOMESCO Finland
Total synovectomy of knee, open
92.0
8.4
9
*
J01DB01
ATC
cefalexin; oral
2.3
8.4
320
2643
N02BE01
ATC
paracetamol; systemic, rectal
2.5
8.4
336
2835
L13
ICPC
Hip symptom/complaint
2.4
8.3
63
292
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.5
8.2
29
88
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
8.2
135
843
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.1
8.0
34
116
J01FA09
ATC
clarithromycin; systemic
1.9
7.9
121
735
S06.0
ICD-10 Finland
Concussion
2.6
7.9
47
194
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
7.8
91
501
M75.3
ICD-10 Finland
Calcific tendinitis of shoulder
15.4
7.8
12
8
NDA30
NOMESCO Finland
Exploration of joint of wrist or hand, arthroscopic
45.9
7.7
9
*
D07AD01
ATC
clobetasol; topical
2.3
7.7
65
315
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
7.6
96
543
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
6.4
7.6
19
31
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
12.2
7.6
13
11
NGF20
NOMESCO Finland
Operation for osteochondritis of knee, open
25.6
7.6
10
*
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
4.4
7.6
19
45
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
7.5
99
569
A01
ICPC
Pain general/multiple sites
2.9
7.5
37
138
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.7
7.3
42
170
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.8
7.3
22
60
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.3
7.3
27
85
M01AH03
ATC
valdecoxib; oral
3.6
7.2
24
70
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.7
7.2
40
159
NBG10
NOMESCO Finland
Acromioplastia
30.6
7.2
9
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
30.6
7.2
9
*
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.4
7.2
53
242
M09AX01
ATC
hyaluronic acid; parenteral
5.8
7.2
19
34
WW200, ,
SPAT
1.9
7.1
111
675
H02AB04
ATC
methylprednisolone; systemic
2.4
7.1
51
230
N06AX21
ATC
duloxetine; oral
2.5
7.0
45
192
DJD20
NOMESCO Finland
Plastic repair of septum of nose
3.7
7.0
22
62
S60.0
ICD-10 Finland
Contusion of finger(s) without damage to nail
3.6
7.0
23
67
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.6
7.0
23
67
A02BC02
ATC
pantoprazole; systemic
1.8
6.9
236
1813
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
11.2
6.8
12
11
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
40.8
6.8
8
*
M65.3
ICD-10 Finland
Trigger finger
7.4
6.8
15
21
W22
ICD-10 Finland
Striking against or struck by other object(s)
2.8
6.8
35
134
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
6.8
48
215
B01AB05
ATC
enoxaparin; parenteral
1.9
6.7
101
605
R52.9
ICD-10 Finland
Pain, unspecified
2.6
6.7
41
171
R51.80
ICD-10 Finland
Headache
2.1
6.7
66
340
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.2
6.6
27
90
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.3
6.6
25
80
M01AB01
ATC
indometacin; systemic, rectal
3.3
6.5
24
75
M01AE11
ATC
tiaprofenic acid; oral, rectal
5.9
6.5
17
30
R4110, ,
SPAT
2.4
6.5
48
219
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
6.4
69
367
L04AX03
ATC
methotrexate; systemic
2.6
6.4
39
163
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
11.3
6.3
11
10
M54.2
ICD-10 Finland
Cervicalgia
2.6
6.3
36
145
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
6.3
70
377
EB1VA, ,
NOMESCO Finland
2.0
6.3
77
430
L12
ICPC
Hand/finger symptom/complaint
2.1
6.3
68
363
M76.6
ICD-10 Finland
Achilles tendinitis
3.5
6.2
21
62
M01AE01
ATC
ibuprofen; systemic, rectal
2.7
6.2
356
3182
R03DC03
ATC
montelukast; oral
2.0
6.2
68
365
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.1
6.2
59
300
R42
ICD-10 Finland
Dizziness and giddiness
2.0
6.1
73
403
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
6.1
68
366
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.6
6.1
20
58
R06.0
ICD-10 Finland
Dyspnoea
1.9
6.0
84
489
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
487
2.46
12.47
1.5
1.2
11.73
11.94
u/ml
0.01
36
200
108
541
2.39
12.23
1.4
1.2
14.86
36.39
iu/ml
2.93
39
159
234
1705
1.96
9.14
4.7
4.9
6.65
6.57
mmol/l
0.17
222
1580
285
2233
2.09
8.94
5.2
3.6
9.33
9.95
mm/h
0.43
276
2102
21
53
4.13
7.72
1.8
1.3
—
—
—
0
0
45
189
2.57
7.26
2.2
2.4
8.55
11.32
au/ml
—
8
15
115
709
1.89
7.06
2.5
2.8
325.79
337.73
umol/l
0.58
105
648
358
3222
2.77
5.89
16.0
11.7
19.78
23.23
mg/l
1.41
295
2544
70
409
1.87
4.93
1.8
1.9
—
—
—
0
0
185
1418
1.59
4.73
2.8
2.7
—
—
estimate
—
0
0
15
43
3.59
4.66
2.1
2.8
5.13
4.91
kpa
0.60
15
43
106
711
1.68
4.64
1.7
1.5
18.86
19.92
nmol/l
0.30
93
620
159
1194
1.57
4.34
5.3
4.8
36.99
36.58
g/l
0.40
154
1138
97
646
1.67
4.33
1.6
1.7
0.74
1.15
mg/l
1.82
70
488
127
910
1.59
4.22
2.4
2.4
51.52
66.46
u/l
1.91
120
856
48
263
1.94
4.09
3.4
2.7
—
—
—
0
0
31
146
2.22
3.93
2.2
3.0
93.87
107.01
ng/l
0.16
23
135
331
2983
1.82
3.91
5.8
4.8
1.80
1.83
mu/l
0.27
313
2798
197
1589
1.50
3.68
3.7
3.2
0.00
0.00
estimate
-0.00
40
314
111
799
1.55
3.53
1.5
1.3
4.69
1.81
u/ml
0.38
27
225
284
2491
1.55
3.40
4.8
4.0
14.64
14.50
pmol/l
0.48
267
2312
148
1144
1.48
3.32
3.3
3.3
33.23
32.89
u/l
0.03
141
1102
189
1536
1.46
3.26
5.9
6.7
10.19
11.05
umol/l
0.88
183
1477
50
299
1.77
3.26
1.7
1.7
—
—
—
0
0
134
1019
1.49
3.25
3.2
3.0
33.60
35.47
ng/l
0.06
84
616
170
1358
1.45
3.19
7.9
7.5
1.23
1.21
mmol/l
2.52
149
1182
192
1574
1.44
3.12
3.7
3.2
0.02
0.00
estimate
0.49
43
312
108
793
1.50
3.09
2.1
2.0
130.04
198.28
u/l
1.90
108
754
195
1606
1.44
3.07
3.7
3.2
0.00
0.01
estimate
0.50
40
298
10
26
3.92
3.00
1.9
2.4
—
—
—
0
0
26
128
2.11
2.99
1.8
1.7
4.58
5.26
iu/ml
—
10
31
24
116
2.14
2.89
1.9
1.6
—
—
—
0
0
19
83
2.36
2.89
1.7
1.2
—
3.49
—
0
12
274
2422
1.46
2.83
3.6
3.2
38.49
46.69
u/l
2.18
265
2324
37
212
1.83
2.79
3.2
2.5
71.60
67.50
ml/min/173m2
—
5
84
30
161
1.94
2.75
9.2
10.6
24.36
24.97
mmol/l
0.37
30
161
15
60
2.56
2.73
1.9
1.3
—
1.01
—
0
7
18
79
2.34
2.72
1.5
1.4
391.50
329.14
ug/g
0.62
12
45
8
19
4.28
2.69
1.0
1.2
—
—
—
0
0
16
67
2.45
2.67
2.0
1.3
—
—
—
0
0
12
41
2.99
2.64
1.1
1.1
—
—
—
0
0
8
20
4.06
2.58
1.0
1.2
—
—
—
0
0
94
694
1.47
2.58
3.4
3.0
1.02
1.02
kg/l
0.26
70
449
146
1177
1.39
2.45
6.8
6.9
1.23
1.21
mmol/l
2.00
140
1089
263
2336
1.40
2.42
8.7
7.6
71.59
77.46
u/l
2.46
254
2231
268
2395
1.40
2.33
3.6
3.3
—
—
—
0
0
24
127
1.95
2.32
1.8
2.6
37.96
38.31
u/l
0.04
24
117
102
780
1.42
2.30
3.8
2.6
0.38
0.37
e6/l
0.03
80
543
44
284
1.62
2.21
1.8
1.8
—
—
—
0
0
18
87
2.12
2.20
3.1
1.9
25.59
25.01
mmol/l
0.26
18
87
145
1185
1.36
2.19
2.1
1.8
100.39
96.07
pmol/l
0.56
84
627
118
936
1.38
2.14
2.7
3.4
2.35
2.36
mmol/l
0.04
107
866
207
1790
1.34
2.13
8.4
9.9
4.16
4.01
e9/l
0.48
180
1556
363
3469
1.93
2.13
12.0
10.1
28.25
27.64
u/l
0.24
355
3394
149
1229
1.35
2.10
3.4
3.0
0.09
0.01
estimate
0.39
32
271
57
396
1.52
2.09
2.1
2.2
2.30
2.36
g/l
0.38
52
369
10
37
2.75
2.08
1.7
1.4
—
—
—
0
0
18
90
2.05
2.04
1.9
1.8
—
—
—
0
0
10
38
2.67
2.02
1.7
1.4
—
—
—
0
0
68
497
1.45
1.95
4.1
3.2
152.76
526.77
ng/l
1.62
44
360
5
11
4.59
1.94
1.0
1.5
1.54
2.20
mmol/l
—
5
11
6
16
3.79
1.94
1.0
1.1
—
—
—
0
0
91
703
1.39
1.92
2.6
2.0
2.31
2.70
mg/l
1.55
82
597
31
190
1.69
1.91
1.9
1.6
—
—
—
0
0
332
3120
1.49
1.88
13.9
11.0
89.35
88.61
ml/min/173m2
0.30
307
2841
6
17
3.57
1.84
5.3
4.9
57.17
195.41
nmol/l
—
6
17
5
12
4.21
1.83
1.0
1.3
—
—
—
0
0
159
1346
1.31
1.82
2.9
2.4
72.65
74.75
nmol/l
0.52
152
1243
9
35
2.61
1.81
1.7
1.4
—
—
—
0
0
7
23
3.08
1.80
1.0
1.1
99.00
76.87
umol/l
—
7
23
12
54
2.26
1.75
1.6
1.9
—
—
—
0
0
9
36
2.54
1.75
1.7
1.4
—
—
—
0
0
9
36
2.54
1.75
1.7
1.4
—
—
—
0
0
18
96
1.92
1.73
2.3
2.1
—
—
—
0
0
49
344
1.49
1.73
2.2
2.7
5.70
6.65
umol/l
0.42
43
300
8
30
2.70
1.73
1.4
1.1
—
—
—
0
0
107
863
1.33
1.71
4.4
4.0
10.75
9.61
mg/mmol
0.10
73
548
13
62
2.14
1.67
1.8
1.2
—
—
—
0
0
6
19
3.19
1.66
1.0
1.1
—
—
—
0
0
327
3082
1.42
1.64
4.8
4.2
5.90
5.80
mmol/l
0.63
310
2885
329
3108
1.42
1.59
4.3
3.9
1.41
1.29
mmol/l
1.80
313
2933
118
974
1.31
1.59
3.7
3.2
8.56
8.37
mmol/l
0.15
102
855
10
44
2.31
1.56
2.2
2.0
15.77
16.98
%
—
10
44
16
86
1.90
1.52
1.4
1.3
—
—
—
0
0
50
364
1.43
1.49
1.7
1.5
1119.17
1124.92
nmol/l
0.02
40
267
305
2858
1.33
1.46
16.0
14.8
13.36
13.39
%
0.17
300
2828
343
3276
1.46
1.44
5.1
4.5
4.73
4.73
mmol/l
0.02
329
3115
30
198
1.56
1.42
2.6
3.7
4.57
4.60
pmol/l
0.06
25
177
118
989
1.28
1.40
3.8
2.8
—
—
—
0
0
342
3269
1.44
1.39
5.0
4.4
1.42
1.46
mmol/l
1.03
328
3095
5
17
2.97
1.36
1.2
1.1
295.60
173.92
iu/ml
—
5
17
20
121
1.69
1.33
1.3
1.7
—
—
—
0
0
10
193
0.51
1.33
1.3
1.5
—
—
—
0
0
93
767
1.28
1.25
1.7
1.6
—
—
—
0
0
40
538
0.71
1.22
3.0
2.9
0.55
0.71
ug/l
0.83
20
310
5
19
2.65
1.22
1.2
1.2
—
—
—
0
0
315
2988
1.31
1.20
5.8
5.2
38.54
38.26
mmol/mol
0.23
302
2853
22
141
1.59
1.20
1.7
1.3
—
—
—
0
0
6
26
2.33
1.19
1.0
1.6
—
—
—
0
0
8
38
2.13
1.19
1.9
1.4
—
—
—
0
0
30
210
1.47
1.12
1.6
1.5
—
—
—
0
0
5
21
2.40
1.09
1.0
1.4
5.30
6.73
mmol/l
—
5
21
44
333
1.36
1.08
2.8
2.3
13.05
14.08
nmol/l
0.43
39
309
27
187
1.48
1.07
1.1
1.0
—
—
—
0
0
67
542
1.29
1.05
1.6
1.7
498.45
32438433.34
pmol/l
0.69
58
484
342
3300
1.35
1.00
5.4
4.9
2.87
2.82
mmol/l
0.60
328
3132
34
251
1.39
0.98
1.3
1.2
87.52
165.56
u/ml
0.84
12
106
94
803
1.23
0.93
4.1
3.3
0.00
0.01
estimate
0.74
38
307
6
28
2.16
0.92
1.5
2.4
—
—
—
0
0
6
29
2.09
0.89
1.5
2.4
—
—
—
0
0
21
144
1.48
0.89
5.8
9.4
24.95
24.30
mmol/l
0.39
21
134
33
247
1.37
0.89
3.9
3.5
2.15
1.54
mmol/l
0.37
26
206
60
493
1.26
0.84
3.6
2.6
2.43
2.43
mmol/l
0.07
52
447
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
8
48
1.68
0.79
3.6
1.5
—
—
—
0
0
107
941
1.19
0.79
3.1
2.7
0.03
0.01
estimate
0.26
33
258
0
28
0.00
0.76
0.0
2.0
—
1715.94
—
0
8
5
24
2.10
0.75
1.4
1.0
—
—
—
0
0
5
24
2.10
0.75
1.2
1.0
—
—
—
0
0
5
24
2.10
0.75
1.2
1.2
7.40
9.87
mm/h
—
5
24
5
24
2.10
0.75
1.2
1.1
—
—
—
0
0
5
25
2.01
0.73
1.4
1.0
—
—
—
0
0
5
25
2.01
0.73
1.4
1.0
—
—
—
0
0
74
636
1.20
0.70
2.5
3.2
764.42
880.33
ng/l
0.22
60
515
5
27
1.86
0.68
1.4
1.0
—
—
—
0
0
16
111
1.46
0.67
4.6
8.8
1.97
1.68
%
0.31
16
102
60
508
1.21
0.66
1.5
1.8
1.33
1.38
%
0.30
50
456
35
279
1.28
0.65
9.3
11.4
0.55
1.06
mmol/l
0.31
29
221
35
280
1.28
0.63
9.1
11.4
12.12
12.55
kpa
0.33
35
266
35
280
1.28
0.63
9.2
11.4
5.07
5.15
kpa
0.25
35
264
14
96
1.48
0.62
1.6
2.1
3.37
5.09
iu/l
—
7
53
9
139
0.64
0.61
3.0
2.5
0.64
0.62
%
—
9
139
9
141
0.63
0.61
3.0
2.5
0.97
1.27
%
—
9
141
8
51
1.58
0.61
2.5
1.6
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
29
228
1.29
0.60
10.8
13.0
124.93
124.38
g/l
0.05
29
222
53
449
1.21
0.59
3.3
2.5
2.93
2.79
e6/l
0.05
30
205
8
55
1.46
0.56
1.6
1.9
—
—
—
0
0
9
60
1.51
0.54
1.0
1.2
—
—
—
0
0
6
38
1.59
0.54
1.0
1.1
—
—
—
0
0
6
39
1.55
0.53
1.2
1.7
—
—
—
0
0
82
730
1.16
0.53
2.7
2.2
—
—
—
0
0
6
40
1.51
0.52
1.0
1.3
—
—
—
0
0
33
398
0.81
0.50
1.3
1.7
3.90
3.46
mmol/l
1.05
20
290
13
93
1.41
0.49
1.5
1.3
—
—
—
0
0
7
49
1.44
0.46
1.0
1.1
—
1.37
—
0
5
55
484
1.16
0.42
3.6
2.4
0.28
0.92
e6/l
3.95
32
237
5
32
1.57
0.42
1.0
1.0
—
—
—
0
0
53
600
0.86
0.41
1.8
1.6
—
—
—
0
0
5
33
1.52
0.41
1.0
1.5
237.80
166.20
pmol/l
—
5
33
8
59
1.36
0.41
1.1
1.5
5.63
7.32
mmol/l
—
8
51
12
88
1.38
0.40
1.1
1.1
0.53
1.82
u/ml
—
7
40
8
61
1.32
0.39
1.1
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
12
158
0.75
0.38
1.6
1.5
—
—
—
0
0
12
158
0.75
0.38
1.6
1.5
1.51
1.20
ratio
—
6
100
12
158
0.75
0.38
1.6
1.5
0.93
0.97
ratio
—
6
100
12
158
0.75
0.38
1.6
1.5
1.37
1.10
ratio
—
6
100
93
860
1.11
0.34
4.4
4.5
1.24
2.24
ug/l
1.63
85
781
10
133
0.75
0.34
1.8
1.6
—
—
—
0
0
7
52
1.35
0.31
1.1
1.1
1.46
1.46
g/l
—
7
46
8
106
0.75
0.29
1.4
1.9
—
—
—
0
0
7
57
1.23
0.29
1.1
2.1
0.00
0.00
g/l
—
7
49
38
337
1.14
0.28
4.8
4.2
30.86
31.21
%
0.08
29
238
18
149
1.22
0.28
13.4
13.8
95.37
93.41
%
1.75
18
149
15
183
0.81
0.28
1.0
1.4
—
—
—
0
0
8
63
1.28
0.28
2.4
1.6
—
—
—
0
0
18
150
1.21
0.27
12.1
13.6
23.41
24.63
mmol/l
0.80
18
145
10
127
0.78
0.26
1.6
1.6
—
—
—
0
0
9
72
1.26
0.26
1.1
1.5
—
—
—
0
0
25
287
0.86
0.25
5.8
5.9
—
—
—
0
0
11
137
0.80
0.24
1.2
1.4
—
—
—
0
0
142
1362
1.07
0.23
2.1
1.9
1.45
1.37
mmol/l
0.52
126
1189
7
91
0.76
0.22
1.3
1.6
44.07
52.44
ug/l
—
7
91
7
92
0.76
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
12.99
—
0
11
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
72.16
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
11
89
1.24
0.21
1.7
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
2.5
—
1.31
—
0
13
6
48
1.25
0.20
1.3
2.9
6.85
7.90
pmol/l
—
6
48
6
50
1.20
0.20
1.0
1.6
—
—
—
0
0
66
702
0.93
0.19
4.0
3.9
25.24
21.39
%
0.71
23
296
7
61
1.15
0.17
5.0
4.4
1.45
2.17
ratio
—
7
37
7
62
1.13
0.17
1.1
1.5
—
—
—
0
0
7
63
1.11
0.17
1.1
2.1
0.00
0.00
g/l
—
7
57
18
158
1.15
0.16
1.4
1.5
123.56
224.44
miu/ml
—
10
85
8
71
1.13
0.16
4.6
4.7
27.24
52.14
mg/l
—
8
61
8
71
1.13
0.16
4.6
4.7
19.15
53.99
mg/l
—
8
62
21
189
1.12
0.14
1.3
2.4
16315.71
5648.64
u/l
—
7
80
10
85
1.18
0.12
2.3
2.5
—
—
—
0
0
33
353
0.93
0.11
2.6
2.1
—
—
—
0
0
11
96
1.15
0.10
6.0
4.3
23.86
25.12
mmol/l
0.83
11
91
5
44
1.14
0.10
1.0
1.0
—
1.35
—
0
10
15
136
1.11
0.08
9.9
17.2
16.50
16.29
%
0.12
15
129
17
185
0.92
0.08
1.4
1.2
0.88
0.91
g/l
0.12
17
185
57
590
0.96
0.07
1.9
2.1
—
—
—
0
0
9
87
1.04
0.07
1.9
1.6
—
—
—
0
0
8
91
0.88
0.07
1.0
1.1
—
—
—
0
0
17
183
0.93
0.06
1.4
1.1
1.45
1.54
g/l
0.83
17
183
52
537
0.96
0.06
1.7
2.0
—
—
—
0
0
31
296
1.05
0.06
2.5
2.1
—
—
—
0
0
10
110
0.91
0.05
2.5
1.8
173.20
220.55
pmol/l
—
10
105
23
219
1.05
0.04
3.1
3.0
4.35
4.64
kpa
0.47
23
210
20
190
1.06
0.04
1.6
1.7
0.37
0.30
mg/l
—
8
96
51
519
0.98
0.02
1.7
2.0
3.86
3.55
ratio
0.88
36
410
15
147
1.02
0.00
1.3
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.01
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
48.17
—
0
6
0
9
0.00
-0.00
0.0
2.6
—
41.89
—
0
9
5
55
0.91
-0.00
1.6
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYNOHYPERTROPH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOHYPERTROPH | 0.855 [0.66, 1.11] | 0.242 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1348 females with M13_SYNOHYPERTROPH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOHYPERTROPH | 0.647 [0.51, 0.83] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 1281 males with M13_SYNOHYPERTROPH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYNOHYPERTROPH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.068% | 0.126% |
| 5 | 0.399% | 0.722% |
| 10 | 0.962% | 1.892% |
| 15 | 1.923% | 3.781% |
| 20 | 3.398% | 6.383% |
Relationships between endpoints
↥Index endpoint: M13_SYNOHYPERTROPH – Synovial hypertrophy, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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