Osteomyelitis of vertebra

M13_OSTEOMYELVERTEB

spondyloarthropathy: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M46.2
  • Cause of death: ICD-10 M46.2

2 out of 7 registries used, show all original rules.

129

4. Check minimum number of events

None

129

5. Include endpoints

None

129

6. Filter based on genotype QC (FinnGen only)

120

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M46
Name in latin
Osteomyelitis vertebrae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 937 363 565
Only index persons 806 323 483
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 63.49 65.55 62.11
Only index persons 62.54 64.59 61.16

-FinnGen-

Key figures

All Female Male
Number of individuals 120 44 76
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 63.65 59.04 66.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
124
Matched controls
1240
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M46.2
ICD-10 Finland
Osteomyelitis of vertebra
+∞
179.0
124
*
M46.3
ICD-10 Finland
Infection of intervertebral disc (pyogenic)
+∞
40.9
37
*
M46.4
ICD-10 Finland
Discitis, unspecified
+∞
39.7
36
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
231.5
34.7
34
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
64.8
32.8
37
8
M54.9
ICD-10 Finland
Dorsalgia, unspecified
12.7
29.0
32
33
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
29.9
26.2
35
16
J01MA12
ATC
levofloxacin; systemic
6.5
23.5
56
139
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
8.8
22.5
33
49
M48.0
ICD-10 Finland
Spinal stenosis
61.9
22.1
25
5
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
46.4
21.8
26
7
N03AX16
ATC
[U] pregabalin
6.6
21.5
45
98
N06AX21
ATC
duloxetine; oral
9.9
20.9
27
34
J01FF01
ATC
clindamycin; systemic
5.4
19.9
64
203
L28
ICPC
Limited function/disability (L)
5.8
18.2
44
108
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.9
17.8
41
96
M54.5
ICD-10 Finland
Low back pain
5.0
17.6
57
179
N02AX02
ATC
tramadol; systemic, rectal
4.9
17.3
77
309
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
8.4
17.2
25
36
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
31.2
16.2
21
8
J04AB02
ATC
rifampicin; systemic
97.7
16.0
17
*
M54.4
ICD-10 Finland
Lumbago with sciatica
6.8
15.6
28
51
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.1
15.4
23
34
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
14.9
14
*
N02AA05
ATC
oxycodone; systemic
4.7
14.8
46
137
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
60.7
14.2
16
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.6
14.1
90
450
A41.9
ICD-10 Finland
Sepsis, unspecified
13.9
14.0
24
21
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.5
13.3
43
131
UKC02
NOMESCO Finland
Cystoscopy
4.4
12.4
40
121
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.9
12.2
53
199
N03AX12
ATC
[U] gabapentin; oral
5.3
11.7
27
62
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
+∞
11.6
11
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.7
11.1
54
216
UJF32
NOMESCO Finland
Coloscopy
3.7
10.7
47
175
L03
ICPC
Low back symptom/complaint
3.8
10.5
43
153
ZXD05
NOMESCO Finland
Urgent procedure
3.4
10.3
56
239
J01CF05
ATC
flucloxacillin; systemic
5.9
10.2
20
39
X59
ICD-10 Finland
Exposure to unspecified factor
4.0
10.2
36
115
A46
ICD-10 Finland
Erysipelas
4.1
10.1
34
105
C03CA01
ATC
furosemide; systemic
3.3
9.6
58
261
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
9.5
53
227
G06.1
ICD-10 Finland
Intraspinal abscess and granuloma
+∞
9.5
9
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.7
9.4
19
38
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
9.3
41
152
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
26.3
9.1
12
5
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
53.9
8.8
10
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
8.7
40
151
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
29.9
8.6
11
*
SPAT1262
SPAT
Handing over of treatment supplies
3.6
8.6
35
122
A06AD11
ATC
lactulose; oral
3.9
8.6
29
89
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
96.3
8.5
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.3
8.5
44
179
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
+∞
8.4
8
*
I50.9
ICD-10 Finland
Heart failure, unspecified
3.5
8.4
35
124
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.0
8.4
63
317
N30.0
ICD-10 Finland
Acute cystitis
3.9
8.3
28
86
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
18.8
8.3
12
7
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.8
8.2
30
97
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
35.9
8.2
10
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
23.9
8.2
11
5
AA1AD
NOMESCO Finland
CT of head and brain
3.0
8.1
52
239
JN3AD
NOMESCO Finland
Abdominal CT examination
4.1
8.0
25
72
A40.8
ICD-10 Finland
Other streptococcal sepsis
16.4
7.9
12
8
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.8
7.8
28
89
J01XX08
ATC
linezolid; systemic
48.1
7.8
9
*
R51.80
ICD-10 Finland
Headache
3.7
7.7
28
90
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.7
7.7
28
90
WX892
NOMESCO Finland
Monitored bed care
5.0
7.7
18
41
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
26.9
7.7
10
*
R50.9
ICD-10 Finland
Fever, unspecified
3.5
7.7
32
113
Z01.8
ICD-10 Finland
Other specified special examinations
3.3
7.6
35
131
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
85.0
7.5
8
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.9
7.4
25
76
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.7
7.3
18
43
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.4
7.3
30
105
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.6
7.1
27
89
ZXE00
NOMESCO Finland
One hour or less
2.7
7.0
59
308
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.9
7.0
43
190
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.4
7.0
19
49
J01CF02
ATC
cloxacillin; systemic
17.9
6.9
10
6
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
17.9
6.9
10
6
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
42.4
6.8
8
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
8.6
6.8
14
18
N02BF01
ATC
gabapentin; oral
4.6
6.8
17
41
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.6
6.8
15
22
TK800
NOMESCO Finland
Hemodialysis
10.9
6.7
12
12
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.2
6.7
19
51
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
6.0
6.4
17
32
N05AH04
ATC
quetiapine; oral
3.3
6.4
28
101
205
Kela drug reimbursment
Chronic hypertension
2.7
6.4
47
227
J45
ICD-10 Finland
Asthma
4.4
6.4
17
43
M03BX02
ATC
tizanidine; oral
2.6
6.3
77
476
NA3CM
NOMESCO Finland
Lumbar spine extensive MRI examination with 3 Tesla magnet
+∞
6.3
6
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
+∞
6.3
6
*
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
6.3
6
*
N05BA04
ATC
oxazepam; oral
2.8
6.3
42
193
A28
ICPC
Limited function/disability NOS
3.0
6.3
33
133
C03DA01
ATC
spironolactone; oral
3.3
6.2
26
91
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
13.5
6.2
10
8
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.7
6.1
21
65
R31
ICD-10 Finland
Unspecified haematuria
3.5
6.0
23
76

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
51
144
5.32
17.93
4.0
1.9
—
—
—
0
0
74
315
4.35
14.75
13.5
4.5
—
—
—
0
0
22
35
7.43
13.80
6.0
3.1
24.42
25.58
mmol/l
0.38
22
35
77
363
3.96
12.72
12.7
5.5
—
—
—
0
0
92
499
4.27
12.16
22.5
12.2
1.28
1.26
inr
0.13
87
420
21
20
12.39
11.82
11.7
6.4
13.99
9.81
mg/l
2.50
21
20
91
514
3.89
10.77
17.0
7.0
1.20
1.21
mmol/l
1.01
76
445
30
83
4.45
10.30
3.1
2.1
—
—
—
0
0
17
18
10.75
9.11
6.6
2.9
15.38
16.29
%
0.35
17
18
59
277
3.16
9.00
4.1
2.9
370.14
362.82
umol/l
0.18
50
243
18
23
8.96
8.73
6.7
2.8
84.01
87.89
%
0.42
18
23
19
29
7.53
8.28
6.7
2.6
7.45
7.72
kpa
0.20
19
29
27
81
3.98
8.23
4.8
3.4
1.19
1.23
mmol/l
2.46
27
68
56
267
3.00
8.15
3.4
2.0
3.17
2.90
mg/l
0.34
48
230
41
164
3.24
8.08
12.1
5.4
1.08
1.08
mmol/l
0.05
41
151
14
13
11.96
8.03
4.0
1.5
1.56
1.54
mmol/l
0.03
14
13
12
8
16.42
7.89
3.4
1.4
92.08
87.55
%
—
12
8
16
20
9.01
7.88
8.6
2.8
2.19
1.51
mmol/l
—
10
13
57
279
2.93
7.85
6.7
3.1
—
—
—
0
0
70
392
2.80
7.35
5.9
3.6
360.02
151.11
e6/l
0.42
63
279
16
23
7.82
7.27
8.6
3.4
—
—
—
0
0
14
16
9.70
7.27
2.9
1.6
—
—
—
0
0
26
85
3.61
6.96
5.8
4.9
0.69
0.30
%
0.35
16
22
29
103
3.37
6.83
3.0
1.7
—
—
—
0
0
40
175
2.90
6.60
2.7
1.5
1267.94
1137.04
nmol/l
0.41
30
133
24
77
3.62
6.58
10.8
4.2
—
—
—
0
0
18
48
4.22
6.35
7.5
3.1
—
—
—
0
0
31
120
3.11
6.32
2.9
2.9
74.19
69.97
e9/l
0.29
26
87
74
450
2.60
6.26
4.8
2.6
150.42
155.25
ug/l
0.09
69
417
89
597
2.74
6.07
18.5
10.9
4.39
4.24
e9/l
0.25
84
522
44
211
2.68
6.04
2.4
1.8
562.65
426.48
pmol/l
1.30
34
173
32
132
2.92
5.81
1.3
1.2
17.09
9.44
u/ml
—
10
54
16
32
5.58
5.81
1.4
1.2
—
—
—
0
0
25
90
3.23
5.72
5.6
5.2
5.33
0.45
%
0.42
15
20
9
7
13.72
5.67
1.2
1.3
—
—
—
0
0
58
328
2.44
5.55
4.5
2.4
—
—
—
0
0
57
320
2.45
5.54
8.6
4.2
7.40
7.40
ph
0.44
52
226
24
86
3.22
5.52
6.5
4.8
0.00
0.29
%
1.26
14
21
35
156
2.73
5.48
2.7
1.9
—
—
—
0
0
15
30
5.54
5.46
2.1
1.2
—
—
—
0
0
25
93
3.11
5.40
6.4
4.7
0.70
1.14
%
0.48
15
28
72
453
2.41
5.38
2.4
2.0
94.88
92.83
pmol/l
0.11
36
240
67
409
2.39
5.35
8.0
4.0
46.26
36.43
ng/l
0.41
57
308
11
15
7.93
5.27
4.2
1.8
3.98
4.60
e9/l
0.40
11
15
38
181
2.59
5.19
2.6
1.7
32.42
29.17
s
2.71
38
176
52
295
2.31
4.80
2.2
1.7
15.58
19.81
nmol/l
1.40
45
242
15
43
3.83
4.78
1.4
1.2
—
—
—
0
0
33
155
2.54
4.59
1.3
1.2
57.33
29.57
iu/ml
—
9
52
12
23
5.66
4.59
4.3
1.7
57.25
61.63
%
0.70
12
23
9
12
7.98
4.44
1.3
1.3
—
—
—
0
0
27
119
2.62
4.25
7.8
3.2
7.36
7.37
ph
0.59
19
72
11
21
5.64
4.25
1.5
1.4
—
—
—
0
0
26
113
2.65
4.21
2.0
1.4
—
—
—
0
0
25
107
2.67
4.17
11.3
8.1
—
—
—
0
0
68
449
2.14
4.16
4.6
2.8
—
—
estimate
—
0
0
43
237
2.25
4.15
7.4
6.1
—
—
—
0
0
27
124
2.51
3.90
10.1
7.4
-0.04
1.13
mmol/l
0.44
22
108
14
39
3.91
3.85
4.2
2.5
1.61
3.08
ratio
—
9
18
27
125
2.48
3.83
10.5
7.3
7.40
7.42
ph
0.60
15
74
22
92
2.69
3.82
2.7
2.6
0.56
0.24
e6/l
0.64
22
86
9
16
5.97
3.73
1.2
1.4
—
—
—
0
0
22
94
2.63
3.66
10.4
4.5
7.38
7.39
ph
0.42
15
63
8
13
6.49
3.56
2.0
1.2
—
—
—
0
0
10
23
4.63
3.39
1.0
1.2
284.00
399.00
u/ml
—
5
10
16
60
2.91
3.38
3.4
4.3
—
—
—
0
0
19
80
2.62
3.25
2.1
2.0
0.00
0.00
estimate
—
6
15
11
30
3.92
3.17
1.0
1.3
—
—
—
0
0
6
8
7.81
3.09
1.2
1.4
—
—
—
0
0
48
304
1.94
3.07
7.4
3.3
0.00
0.27
estimate
0.49
22
92
5
5
10.34
3.00
2.2
1.0
—
—
—
0
0
9
22
4.33
2.94
1.3
3.1
4.36
9.59
pmol/l
—
9
22
7
13
5.63
2.91
1.1
2.0
—
—
—
0
0
7
13
5.63
2.91
2.3
1.7
31.86
32.46
pg
—
7
13
6
9
6.94
2.90
1.2
1.0
—
—
—
0
0
34
194
2.04
2.90
1.9
1.4
3.45
2.57
g/l
1.08
28
114
8
18
4.67
2.84
2.8
1.7
—
—
—
0
0
23
114
2.25
2.78
2.4
1.7
—
—
—
0
0
5
6
8.61
2.77
1.4
1.0
174.00
92.57
iu/ml
—
5
6
7
14
5.23
2.77
4.0
2.6
—
—
—
0
0
72
533
1.84
2.75
6.7
3.6
0.00
0.00
estimate
-0.00
26
112
6
10
6.24
2.73
1.0
1.6
5.55
4.69
mg/l
—
6
10
72
537
1.81
2.65
6.9
3.6
0.00
0.00
estimate
-0.00
29
113
7
15
4.88
2.63
1.0
1.1
—
—
—
0
0
46
301
1.84
2.59
7.0
3.6
0.00
0.02
estimate
0.50
24
108
5
7
7.38
2.57
1.0
1.4
1.89
2.09
mmol/l
—
5
7
72
543
1.78
2.50
6.8
3.6
0.00
2.94
estimate
0.50
28
102
6
12
5.19
2.43
2.3
4.6
—
—
—
0
0
89
718
1.85
2.43
4.4
3.7
15.00
14.95
pmol/l
0.06
79
634
5
8
6.45
2.39
1.0
1.4
—
—
—
0
0
59
425
1.74
2.37
4.6
3.3
6.29
6.11
ph
0.74
38
248
16
73
2.37
2.33
11.1
9.7
93.08
93.12
%
0.01
16
73
24
132
2.01
2.23
2.5
1.6
—
—
—
0
0
65
487
1.70
2.22
30.5
11.4
0.00
0.01
e9/l
0.51
59
398
8
24
3.49
2.22
3.1
1.6
—
—
—
0
0
8
24
3.49
2.22
3.1
1.7
—
—
—
0
0
6
14
4.44
2.18
1.0
1.1
—
—
—
0
0
8
25
3.35
2.13
3.1
1.6
—
—
—
0
0
8
25
3.35
2.13
3.1
1.6
—
—
—
0
0
8
25
3.35
2.13
3.1
1.6
—
—
—
0
0
10
38
2.77
2.06
1.8
3.3
—
—
—
0
0
10
39
2.70
1.99
4.4
1.6
—
—
—
0
0
35
227
1.75
1.97
4.8
3.3
930.37
335.79
ng/l
0.47
27
184
5
11
4.69
1.96
2.2
2.7
2.74
-0.27
mmol/l
—
5
11
5
12
4.29
1.84
2.8
1.8
—
—
—
0
0
5
12
4.29
1.84
1.2
1.1
—
—
—
0
0
8
29
2.88
1.82
1.1
1.1
—
50.00
—
0
5
111
994
2.11
1.80
59.2
15.3
29.45
26.36
mg/l
0.48
104
814
9
36
2.61
1.78
2.4
2.7
—
—
—
0
0
55
414
1.59
1.73
7.2
3.6
0.05
0.03
estimate
0.10
22
98
18
100
1.94
1.63
1.5
1.4
—
—
—
0
0
103
910
1.78
1.60
5.8
4.7
2.20
1.99
mu/l
0.62
92
814
5
15
3.43
1.54
1.2
1.1
—
—
—
0
0
31
208
1.65
1.53
1.4
1.3
1.31
0.79
u/ml
—
9
53
20
119
1.81
1.49
1.2
1.2
—
—
—
0
0
5
16
3.21
1.45
6.4
2.6
1.26
1.21
mmol/l
—
5
16
5
16
3.21
1.45
6.4
2.6
107.20
104.81
mmol/l
—
5
16
5
16
3.21
1.45
6.4
2.6
4.02
4.11
mmol/l
—
5
16
10
47
2.23
1.38
1.1
1.2
—
30.20
—
0
5
5
18
2.85
1.29
1.2
1.3
—
—
—
0
0
47
362
1.48
1.26
4.9
3.5
167.67
59.70
mg/l
0.93
37
254
16
95
1.79
1.20
1.1
1.3
—
—
—
0
0
48
377
1.45
1.15
5.2
3.5
6.89
8.06
mmol/l
1.49
38
315
5
21
2.44
1.10
1.6
1.5
—
—
—
0
0
5
21
2.44
1.10
1.6
1.5
—
—
—
0
0
5
21
2.44
1.10
1.6
1.5
—
—
—
0
0
5
21
2.44
1.10
1.6
1.5
—
—
—
0
0
50
400
1.42
1.07
1.8
2.1
—
—
—
0
0
47
372
1.42
1.07
6.8
4.3
37.81
11.07
mg/mmol
1.23
34
249
11
60
1.91
1.06
5.0
2.9
1.33
1.32
%
0.01
11
60
51
416
1.38
0.96
2.2
2.0
1.57
1.36
mmol/l
0.94
41
331
41
323
1.40
0.94
15.0
6.4
—
—
—
0
0
59
498
1.35
0.88
5.1
5.5
1.58
3.08
ug/l
1.37
51
449
112
1053
1.66
0.87
60.0
18.3
139.26
139.59
mmol/l
0.82
112
1026
112
1053
1.66
0.87
61.1
18.5
4.06
3.99
mmol/l
1.94
112
1025
13
81
1.68
0.85
3.2
2.5
6.34
9.79
ug/l
0.45
13
74
6
32
1.92
0.83
8.8
2.9
1.38
1.54
mmol/l
—
6
32
8
48
1.71
0.80
1.1
1.2
—
—
—
0
0
10
59
1.76
0.78
4.2
2.7
0.58
0.58
%
—
10
59
9
53
1.75
0.77
2.6
2.8
4.23
4.36
pmol/l
—
9
47
18
126
1.50
0.75
1.4
1.3
—
—
—
0
0
7
38
1.89
0.75
1.3
1.2
—
—
—
0
0
19
136
1.47
0.72
1.2
1.3
—
—
—
0
0
5
27
1.89
0.69
10.4
2.9
10.22
8.10
mmol/l
—
5
27
113
1082
1.50
0.57
62.7
20.6
105.29
82.05
umol/l
1.69
113
1064
12
82
1.51
0.57
1.3
1.6
—
—
—
0
0
114
1102
1.43
0.43
72.7
23.8
4.19
4.52
e12/l
6.91
114
1066
114
1102
1.43
0.43
73.3
23.8
252.03
238.39
e9/l
0.97
114
1072
114
1102
1.43
0.43
73.5
23.9
125.81
136.28
g/l
8.10
114
1085
114
1102
1.43
0.43
72.4
23.7
91.97
91.20
fl
0.81
114
1086
114
1102
1.43
0.43
72.4
23.7
30.19
30.43
pg
0.63
114
1086
5
36
1.40
0.38
5.4
5.6
—
—
—
0
0
6
45
1.35
0.34
1.0
1.1
—
—
—
0
0
7
53
1.34
0.31
3.1
3.7
37.06
37.01
°c
—
7
53
9
74
1.23
0.26
4.7
3.4
—
—
—
0
0
26
294
0.85
0.25
2.6
3.2
0.64
0.84
ug/l
1.06
18
197
30
267
1.16
0.25
1.5
1.4
—
—
—
0
0
102
988
1.18
0.24
6.4
5.1
6.34
6.04
mmol/l
0.90
89
890
0
11
0.00
0.21
0.0
21.0
—
1510.73
—
0
11
0
11
0.00
0.21
0.0
18.7
—
944.27
—
0
11
0
10
0.00
0.21
0.0
1.2
—
237.16
—
0
10
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
99
961
1.15
0.20
9.7
6.8
42.15
39.88
mmol/mol
1.11
91
898
99
965
1.13
0.16
5.2
4.4
1.34
1.27
mmol/l
0.53
88
877
11
97
1.15
0.09
1.5
1.6
—
—
—
0
0
8
75
1.07
0.07
1.4
1.2
—
—
—
0
0
22
233
0.93
0.06
4.1
3.3
—
0.40
—
0
5
41
404
1.02
0.00
4.6
3.5
—
—
—
0
0
103
1032
0.99
0.00
6.8
5.8
2.36
2.63
mmol/l
2.38
91
941
101
1011
0.99
0.00
6.4
5.1
4.20
4.51
mmol/l
2.20
91
929
0
7
0.00
-0.00
0.0
1.3
—
7.51
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
26.80
—
0
5
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
176.00
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
10.68
—
0
5
5
57
0.87
-0.00
2.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
101
1010
1.00
-0.00
6.2
5.1
1.32
1.43
mmol/l
1.90
90
919
7
75
0.93
-0.00
1.1
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
67.60
—
0
5
0
6
0.00
-0.00
0.0
6.7
—
32.68
—
0
6
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_OSTEOMYELVERTEB and mortality.

Females

Parameter HR [95% CI] p-value
M13_OSTEOMYELVERTEB 1.996 [1.5, 2.65] < 0.001
Birth year 0.99 [0.98, 1.0] 0.024

During the follow-up period (1.1.1998 — 31.12.2019), 121 out of 325 females with M13_OSTEOMYELVERTEB died.

Males

Parameter HR [95% CI] p-value
M13_OSTEOMYELVERTEB 2.433 [1.84, 3.22] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 201 out of 503 males with M13_OSTEOMYELVERTEB died.

Mortality risk

Mortality risk for people of age

years, who have M13_OSTEOMYELVERTEB.

N-year risk Females Males
1 0.15% 0.363%
5 0.982% 2.718%
10 2.528% 6.78%
15 4.728% 12.398%
20 8.398% 20.461%

Relationships between endpoints

Index endpoint: M13_OSTEOMYELVERTEB – Osteomyelitis of vertebra

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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