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Other specified/unspecified necrotizing vasculopathies

EFO MESH Endpoint Browser PheWeb

M13_NECROVASCNAS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M31.8, M31.9
  • Hospital discharge: ICD-9 — 447[5-6]
  • Hospital discharge: ICD-8 — 4469
  • Cause of death: ICD-10 — M31.8, M31.9
  • Cause of death: ICD-9 — 447[5-6]
  • Cause of death: ICD-8 — 4469

2 out of 7 registries used, show all original rules.

562

4. Check minimum number of events

None

562

5. Include endpoints

None

562

6. Filter based on genotype QC (FinnGen only)

508

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3624 1976 1609
Only index persons 2728 1510 1218
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.05 0.06 0.05
Median age at first event (years)
Whole population 61.78 62.38 60.96
Only index persons 59.20 59.37 58.98

-FinnGen-

Key figures

All Female Male
Number of individuals 508 273 235
Unadjusted period prevalence (%) 0.10 0.10 0.11
Median age at first event (years) 57.84 54.95 61.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
520
Matched controls
5200
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
307.7
302
*
L04AX01
ATC
azathioprine; systemic
32.9
232.3
161
70
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
158.7
144
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
10.4
140.0
198
289
L04AA06
ATC
mycophenolic acid; systemic
34.1
116.5
76
26
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
81.4
76
*
H02AB06
ATC
prednisolone; systemic
6.5
80.1
405
1824
M05BA04
ATC
alendronic acid; oral
7.1
73.2
131
237
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.9
70.9
322
1289
4476A
ICD-9 Finland
Other disorders of arteries and arterioles, Arteritis, unspecified
+∞
65.0
61
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
9.6
61.6
78
94
L04AX03
ATC
methotrexate; systemic
6.2
61.3
124
251
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
23.3
58.3
43
20
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
6.8
58.2
103
182
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
15.5
57.8
52
37
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.1
54.5
91
151
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
7.6
53.5
83
127
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
50.9
48
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.5
48.9
50
44
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
48.5
136
361
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
179.9
47.7
49
*
R50.9
ICD-10 Finland
Fever, unspecified
4.3
44.7
148
444
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
8.7
44.3
59
75
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
6.6
43.6
76
131
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
41.9
361
1993
M35.3
ICD-10 Finland
Polymyalgia rheumatica
12.6
41.7
42
36
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
38.4
229
999
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.4
38.1
83
176
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
38.0
36
*
PAW37
NOMESCO Finland
Biopsy of temporal artery
394.2
37.5
37
*
H02AB07
ATC
prednisone; oral
3.9
37.1
134
423
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
35.8
34
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.3
35.6
107
295
44698
ICD-8 Finland
Polyarteritis nodosa and allied conditions, Other
+∞
34.8
33
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
9.6
34.7
42
47
TK800
NOMESCO Finland
Hemodialysis
10.2
34.6
40
42
A11CC03
ATC
alfacalcidol; systemic
9.4
34.1
42
48
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.8
33.8
56
91
A12AA04
ATC
calcium carbonate; oral
13.0
33.6
33
27
N18.8
ICD-10 Finland
Other chronic renal failure
10.0
33.1
39
42
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.5
32.2
67
136
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
31.6
30
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
74.7
31.3
35
5
L01AA01
ATC
cyclophosphamide; systemic
74.7
31.3
35
5
KA1AE
NOMESCO Finland
Kidney ultrasound examination
8.9
31.3
40
48
H02AB04
ATC
methylprednisolone; systemic
3.5
31.0
132
460
Z49.1
ICD-10 Finland
Extracorporeal dialysis
12.6
31.0
31
26
C03CA01
ATC
furosemide; systemic
2.9
30.6
247
1243
P01BA02
ATC
hydroxychloroquine; oral
4.6
30.4
80
198
J01MA12
ATC
levofloxacin; systemic
3.2
29.5
158
632
B03XA02
ATC
darbepoetin alfa; parenteral
10.0
29.1
34
36
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.8
28.6
99
300
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.5
27.4
110
367
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
27.4
119
418
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
27.3
26
*
D69.0
ICD-10 Finland
Allergic purpura
39.0
26.5
33
9
ZX120
NOMESCO Finland
Intravenous
3.8
25.7
90
274
N085, M318,
ICD-10 Finland
+∞
25.2
24
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
25.2
24
*
L01BA01
ATC
methotrexate; systemic
6.4
25.1
43
72
NHQ40
NOMESCO Finland
Amputation of toe
9.1
24.8
31
36
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.4
24.5
51
103
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.4
24.3
65
162
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
6.3
24.2
42
71
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
251.1
23.8
24
*
J01MA14
ATC
moxifloxacin; systemic
3.7
23.7
85
262
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
23.6
142
598
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
5.0
22.9
52
113
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.1
22.8
41
72
M13.9
ICD-10 Finland
Arthritis, unspecified
4.0
22.6
69
190
TGC00
NOMESCO Finland
Bronchial lavation
6.0
22.5
41
73
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.8
22.3
150
668
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
22.0
165
775
J01FF01
ATC
clindamycin; systemic
2.6
21.9
190
957
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.1
21.2
62
165
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
218.4
20.7
21
*
I77.6
ICD-10 Finland
Arteritis, unspecified
218.4
20.7
21
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.2
20.5
59
155
A41.9
ICD-10 Finland
Sepsis, unspecified
5.2
20.3
43
88
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
19.9
19
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.4
19.8
81
271
A46
ICD-10 Finland
Erysipelas
2.8
19.4
117
489
L95.8
ICD-10 Finland
Other vasculitis limited to skin
57.3
19.1
22
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
6.4
18.3
31
51
A10AC01
ATC
insulin (human); parenteral
3.4
18.2
71
230
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.2
18.1
38
77
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
17.8
17
*
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
17.8
17
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.4
17.7
68
218
M31.6
ICD-10 Finland
Other giant cell arteritis
98.5
17.7
19
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
17.5
191
1047
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
16.7
17.2
27
17
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.5
17.2
64
201
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
16.8
16
*
N18.0
ICD-10 Finland
End-stage renal disease
17.0
16.7
26
16
TDM10
NOMESCO Finland
Puncture of maxillary antrum
5.1
16.6
36
75
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.7
16.6
102
428
A02BC02
ATC
pantoprazole; systemic
2.4
16.4
395
2952
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
16.4
88
343
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
16.1
150
765
S97
ICPC
Chronic ulcer skin
3.3
15.8
65
217
Z94.0
ICD-10 Finland
Kidney transplant status
17.9
15.8
24
14
GD1AD
NOMESCO Finland
Thorax CT examination
3.5
15.7
59
186
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
27.3
15.7
21
8
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
15.7
15
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
14.3
15.7
26
19
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
14.6
98
428
A02BC01
ATC
omeprazole; systemic
2.2
14.3
175
991
C08CA05
ATC
nifedipine; systemic
3.4
14.2
53
166
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
14.0
162
895
UJF32
NOMESCO Finland
Coloscopy
2.2
13.8
164
915
ZXD05
NOMESCO Finland
Urgent procedure
2.1
13.7
184
1077
A10AB05
ATC
insulin aspart; parenteral
3.0
13.7
63
225
127
Kela drug reimbursment
Transplant complication
11.4
13.6
25
23
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
13.6
13
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.0
13.6
65
237
WW200
NOMESCO Finland
Immunization
5.4
13.6
27
52
H26.3
ICD-10 Finland
Drug-induced cataract
16.8
13.6
21
13
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.8
13.5
25
45
Z2446
NOMESCO Finland
Social worker
3.4
13.4
51
162
ZXA10
NOMESCO Finland
Bilateral
2.3
13.4
128
654
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
13.5
13.0
22
17
N02AX02
ATC
tramadol; systemic, rectal
2.0
13.0
257
1718
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.7
12.9
77
316
M05BA07
ATC
risedronic acid; oral
4.4
12.9
33
79
V03AE01
ATC
polystyrene sulfonate; oral
10.9
12.9
24
23
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.5
12.8
32
75
JN4AD
NOMESCO Finland
Body CT examination
2.5
12.6
86
377
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
6.4
12.6
21
34
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
12.5
12
*
J01MA02
ATC
ciprofloxacin; systemic
2.0
12.4
229
1488
B01AA03
ATC
warfarin; systemic
2.2
12.4
130
687
H02AB09
ATC
hydrocortisone; systemic
5.5
12.4
24
45
TQW80
NOMESCO Finland
Local dermatologic skincare
5.3
12.3
25
49
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
12.3
116
587
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
13.8
12.0
20
15
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.3
12.0
31
75
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.4
11.9
44
137
UKC02
NOMESCO Finland
Cystoscopy
2.3
11.8
109
546
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
11.8
68
274
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.8
11.8
65
256
L04AA01
ATC
[U] ciclosporin
12.9
11.7
20
16
J01DB01
ATC
cefalexin; oral
2.4
11.7
441
3646
L88
ICPC
Rheumatoid/seropositive arthritis
4.0
11.7
34
90
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.9
11.6
211
1356
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
11.6
129
696
J45.1
ICD-10 Finland
Nonallergic asthma
3.0
11.6
54
194
M04AA01
ATC
allopurinol; systemic
2.4
11.6
89
412
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
11.5
11
*
ZZA00
NOMESCO Finland
Split skin graft
4.3
11.5
30
73
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
15.5
11.4
18
12
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
11.3
126
679
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
4.9
11.3
25
53
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
13.1
11.2
19
15
N03AX16
ATC
[U] pregabalin
2.1
11.1
139
784
R04.0
ICD-10 Finland
Epistaxis
2.9
11.0
56
211
C08CA02
ATC
felodipine; oral
2.6
11.0
68
284
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
15.9
10.9
17
11
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.5
10.9
27
63
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
10.9
10.9
20
19
C08CA01
ATC
amlodipine; oral
1.9
10.7
231
1560
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
10.7
105
538
DHA10
NOMESCO Finland
Biopsy of cavity of nose
11.6
10.6
19
17
Z3231
NOMESCO Finland
Registered nurse
2.0
10.5
161
971
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
10.4
10
*
ZX108
NOMESCO Finland
Inhalation
16.5
10.4
16
10
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
10.9
10.4
19
18
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
23.9
10.3
14
6
QDB10, ,
SPAT
4.1
10.2
28
71
M05BB03
ATC
alendronic acid and colecalciferol; oral
4.5
10.2
25
58
A02BC03
ATC
lansoprazole; oral
1.9
10.2
171
1063
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
10.1
222
1500
TAB00
NOMESCO Finland
Lumbar puncture
3.4
10.1
37
115
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
10.0
83
396
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
40.9
10.0
12
*
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
17.1
9.9
15
9
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
9.8
72
325
M10.9
ICD-10 Finland
Gout, unspecified
2.8
9.7
49
184
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.0
9.6
44
156
R04.2
ICD-10 Finland
Haemoptysis
3.6
9.6
32
93
R06.0
ICD-10 Finland
Dyspnoea
1.9
9.6
165
1030
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
17.9
9.4
14
8
L95.0
ICD-10 Finland
Livedoid vasculitis
101.8
9.4
10
*
M05BA06
ATC
ibandronic acid; systemic
5.3
9.4
19
37
L04AD01
ATC
ciclosporin; systemic
8.3
9.4
20
25
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
9.4
9
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
9.4
9
*
V03AE02
ATC
sevelamer; oral
22.2
9.4
13
6
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.5
9.4
60
254
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.5
9.3
33
100
J45.8
ICD-10 Finland
Mixed asthma
4.3
9.3
24
58
J05AB11
ATC
valaciclovir; oral
2.1
9.2
95
495
205
Kela drug reimbursment
Chronic hypertension
1.9
9.2
159
992
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.7
9.1
21
46
3AC01, ,
NOMESCO Finland
11.7
9.1
16
14
TPH07
NOMESCO Finland
Cathetrisation of artery
2.3
9.1
76
363
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.8
9.1
47
179
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
19.0
9.0
13
7
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.7
8.9
49
192
UDM02
NOMESCO Finland
Sinoscopy
4.8
8.9
20
43
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
8.9
272
2004
L04AD02
ATC
tacrolimus; systemic
11.0
8.8
16
15
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
8.8
131
777
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
8.8
111
623
A12AA12
ATC
[U] calcium acetate
50.9
8.7
10
*
R53
ICD-10 Finland
Malaise and fatigue
1.8
8.6
151
943
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
8.6
110
619
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.6
8.6
53
221
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
20.4
8.5
12
6
ZXA00
NOMESCO Finland
Right side
1.8
8.5
155
980
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.9
8.4
40
145
UJF92
NOMESCO Finland
Capsular endoscopy
4.8
8.4
19
41
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.7
8.4
26
72
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
8.4
8
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.3
8.3
31
97
XG410
NOMESCO Finland
Flow-volume spirometry
3.2
8.2
32
103
1XC02, ,
NOMESCO Finland
14.8
8.2
13
9
A01AB10
ATC
natamycin; local oral
4.1
8.1
22
55
137
Kela drug reimbursment
Uraemia requiring dialysis
12.0
8.1
14
12
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.8
8.1
25
69
Z49.0
ICD-10 Finland
Preparatory care for dialysis
10.3
8.1
15
15
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.7
8.1
45
178
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.5
8.0
50
209
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
8.0
74
368
WX892
NOMESCO Finland
Monitored bed care
2.5
8.0
52
222
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.7
8.0
43
167
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.1
8.0
22
56
J01CA04
ATC
amoxicillin; systemic
1.9
8.0
417
3533
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
3.2
7.9
32
106
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
7.9
53
230
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
7.8
62
289
M05BX04
ATC
denosumab; parenteral
2.7
7.8
43
169
J01FA06
ATC
roxithromycin; oral
1.7
7.8
214
1514
C09AA02
ATC
enalapril; systemic
1.9
7.8
116
686
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.4
7.8
54
238
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
6.9
7.6
18
27
NF1AA
NOMESCO Finland
Hip X-ray examination
2.2
7.6
64
306
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
18.7
7.6
11
6
B34.9
ICD-10 Finland
Viral infection, unspecified
4.2
7.6
20
49
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
3.9
7.6
22
58
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
7.6
108
629
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.3
7.5
19
45
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
7.3
7.5
17
24
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.4
191
1323
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
7.4
116
695
A03
ICPC
Fever
2.0
7.4
89
489
XW000
NOMESCO Finland
Bone marrow biopsy
3.1
7.4
31
105
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.9
7.3
21
55
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.1
7.3
30
100
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
7.3
7
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
7.3
7
*
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
7.3
7
*
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
16.0
7.3
11
7
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
16.0
7.3
11
7
J01AA02
ATC
doxycycline; systemic
1.8
7.2
403
3415
N02AA05
ATC
oxycodone; systemic
1.8
7.2
115
694
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
7.2
235
1731
M81.4
ICD-10 Finland
Drug-induced osteoporosis
20.3
7.2
10
5
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
7.2
67
335
R60.0
ICD-10 Finland
Localized oedema
2.0
7.1
78
414
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.0
7.1
32
113
XX9XE
NOMESCO Finland
Other ultrasound examination
10.2
7.1
13
13
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
7.0
87
482
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
7.0
94
535
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
7.0
76
402
C07AB07
ATC
bisoprolol; oral
1.6
7.0
272
2088
TQW11
NOMESCO Finland
Vacuum treatment of wound
4.1
6.9
19
48
A41.8
ICD-10 Finland
Other specified sepsis
4.1
6.9
19
48
AA1AD
NOMESCO Finland
CT of head and brain
1.7
6.8
169
1154
N06AA09
ATC
amitriptyline; systemic
2.2
6.8
56
265
R31
ICD-10 Finland
Unspecified haematuria
2.1
6.8
67
341
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
3.7
6.8
21
58
Z2221
NOMESCO Finland
Medical doctor
1.7
6.7
143
937
J01CF05
ATC
flucloxacillin; systemic
2.4
6.7
47
208
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
22.8
6.7
9
*
H65.2
ICD-10 Finland
Chronic serous otitis media
6.6
6.7
16
25
J47
ICD-10 Finland
Bronchiectasis
4.1
6.7
18
45
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
6.6
190
1347
I50.0
ICD-10 Finland
Congestive heart failure
2.2
6.6
54
256
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
6.6
132
851
ZY010
NOMESCO Finland
Hospital outpatient
2.9
6.5
30
107
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.4
6.5
18
34
C08DB01
ATC
diltiazem; oral
2.6
6.5
36
142
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.5
6.4
39
161
E11.09
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - With coma
70.7
6.4
7
*
WW400
NOMESCO Finland
Plasmaferesis
70.7
6.4
7
*
A10AA02, ,
ATC
3.1
6.4
26
86
A07AA02
ATC
nystatin; oral
2.6
6.4
37
149
M05BA01
ATC
etidronic acid; systemic
14.5
6.4
10
7
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
6.4
28
97
J02AC01
ATC
fluconazole; systemic
1.6
6.4
187
1330
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.9
6.4
29
103
NGQ20
NOMESCO Finland
Amputation of lower leg
8.3
6.4
13
16
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.4
6.3
42
181
SPAT1254
SPAT
Administration of medicine
1.9
6.3
84
476
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
3.9
6.3
18
47
L93.0
ICD-10 Finland
Discoid lupus erythematosus
18.3
6.3
9
5
N085, M319,
ICD-10 Finland
+∞
6.3
6
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
6.3
6
*
N25.0
ICD-10 Finland
Renal osteodystrophy
27.0
6.2
8
*
99850
ICD-8 Finland
Other complications of surgical procedures, Postoperative wound infection
27.0
6.2
8
*
6BA02, ,
NOMESCO Finland
27.0
6.2
8
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.6
6.2
20
57
J01DA01
ATC
[U] cefalexin
1.6
6.2
314
2539
L28
ICPC
Limited function/disability (L)
1.8
6.2
109
675
I50.1
ICD-10 Finland
Left ventricular failure
2.5
6.2
37
152
D07AC01
ATC
betamethasone; topical
1.6
6.2
188
1348
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
3.8
6.1
18
48
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
4.2
6.1
16
39
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.1
6.0
25
84

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
194
136
22.16
227.48
3.0
1.1
—
—
—
0
0
136
122
14.74
135.39
2.5
1.2
1.21
1.20
g/l
0.06
131
117
111
71
19.61
133.12
3.2
1.1
361.43
—
titre
—
14
0
124
153
10.33
97.78
3.1
1.4
16.00
5.10
iu/ml
1.01
40
38
164
355
6.29
76.70
5.7
2.9
9.25
10.56
g/l
3.19
159
328
209
577
5.38
74.15
1.9
1.3
629.37
393.65
titre
0.94
64
126
129
280
5.80
59.01
2.2
1.7
0.88
1.41
g/l
2.69
123
259
89
146
7.15
53.85
1.6
1.1
0.55
2.75
u/ml
—
6
10
73
99
8.41
52.21
1.5
1.2
1.80
2.68
u/ml
—
11
9
190
626
4.21
51.23
13.7
5.8
1.09
1.04
mmol/l
1.38
180
581
72
100
8.20
50.43
1.5
1.2
14.70
3.12
u/ml
0.58
18
13
321
1533
3.86
49.69
16.3
5.6
—
—
—
0
0
139
378
4.65
48.04
2.1
3.1
64.79
66.67
g/l
1.88
133
352
42
30
15.14
46.42
1.9
1.1
407.50
70.00
titre
—
12
6
56
65
9.53
45.18
2.1
1.9
0.61
0.84
g/l
0.48
39
56
379
2125
3.89
43.72
18.2
5.8
62.76
58.16
%
11.55
372
2023
117
298
4.78
43.61
1.9
3.1
—
—
—
0
0
395
2296
4.00
42.65
18.5
5.7
0.04
0.04
e9/l
0.40
372
1965
394
2291
3.97
42.41
18.6
5.7
0.63
0.59
e9/l
2.79
372
1955
376
2126
3.78
42.15
19.2
6.0
8.63
8.94
%
1.22
368
1997
282
1343
3.40
41.65
7.6
4.4
—
—
—
0
0
41
34
13.01
41.51
1.4
1.4
2.52
2.70
g/l
0.16
29
28
41
34
13.01
41.51
1.4
1.4
0.41
0.35
g/l
0.26
29
28
41
34
13.01
41.51
1.4
1.4
6.27
6.04
g/l
0.12
29
28
396
2335
3.92
41.14
18.8
5.8
1.73
1.89
e9/l
1.26
377
2065
373
2120
3.69
40.98
19.2
5.8
2.49
2.79
%
2.25
364
1987
399
2368
3.94
40.95
19.6
6.0
0.19
0.19
e9/l
0.19
379
2070
377
2162
3.70
40.72
19.1
5.9
23.50
26.81
%
7.68
370
2050
193
739
3.56
40.35
5.4
2.5
2.14
2.29
g/l
3.72
188
680
370
2115
3.60
39.77
19.5
5.9
0.61
0.67
%
1.39
362
1976
198
795
3.41
38.03
5.4
2.6
11.65
12.66
umol/l
1.14
193
736
182
694
3.50
37.97
5.5
2.6
22.32
21.96
%
0.12
177
648
38
36
11.31
35.26
1.5
1.4
—
—
—
0
0
401
2582
3.42
31.96
20.7
9.4
4.85
4.13
e9/l
5.31
387
2239
153
585
3.29
30.99
5.0
2.4
1.89
1.80
%
0.56
142
533
144
535
3.34
30.53
2.9
1.7
—
—
—
0
0
134
477
3.44
30.42
2.3
1.6
—
—
—
0
0
30
25
12.67
30.12
2.3
1.8
48.15
38.12
%
1.80
30
25
60
118
5.62
29.75
2.2
2.3
12.19
13.15
mg/l
0.37
55
111
82
212
4.40
29.42
2.0
1.5
1.70
1.54
g/l
0.62
72
196
195
891
2.90
28.54
2.1
1.4
2.53
2.52
g/l
0.03
158
543
126
455
3.34
27.74
3.4
2.5
69.76
68.54
e9/l
0.14
96
345
36
44
8.72
27.69
1.4
1.2
—
—
—
0
0
65
147
4.91
27.47
2.5
4.6
42.78
86.02
mg/l
0.54
53
127
65
147
4.91
27.47
2.4
4.6
33.13
29.71
mg/l
0.38
55
127
161
677
3.00
27.26
2.4
1.8
—
—
—
0
0
61
132
5.10
27.14
2.3
4.3
3.75
2.39
ratio
0.25
31
72
149
608
3.03
26.53
2.3
1.6
—
—
—
0
0
337
2088
2.74
26.46
10.0
5.1
33.10
35.53
g/l
10.65
326
1957
108
370
3.42
25.73
7.8
4.4
0.52
0.56
%
0.12
54
124
41
64
6.87
25.55
1.5
1.2
3.35
4.96
u/ml
0.45
17
27
50
97
5.60
25.08
1.3
2.0
—
—
—
0
0
363
2372
2.76
24.99
16.6
7.3
1.21
1.21
mmol/l
0.14
310
2044
323
2002
2.62
24.64
4.0
2.4
79.26
77.88
nmol/l
0.40
308
1770
110
391
3.30
24.63
8.5
4.4
0.87
1.00
%
0.23
55
137
75
207
4.07
24.52
3.1
1.8
1.08
2.92
ug/l
0.68
70
180
105
364
3.36
24.47
9.4
3.9
147.60
86.25
ng/l
2.56
98
321
105
366
3.34
24.24
8.7
4.5
0.06
0.17
%
1.22
49
112
336
2143
2.60
23.80
15.4
6.6
1.20
1.21
mmol/l
1.41
321
1957
210
1084
2.57
23.25
7.8
2.6
3.79
4.99
e6/l
1.37
203
984
171
803
2.68
22.94
4.4
3.3
0.82
0.82
mmol/l
0.23
158
761
103
372
3.21
22.32
9.3
4.8
0.21
0.18
%
0.05
43
102
215
1151
2.48
21.70
4.5
2.8
352.45
349.75
umol/l
0.14
200
995
92
316
3.32
21.62
1.5
1.4
—
—
—
0
0
112
433
3.02
21.54
2.4
1.9
291.85
386.20
nmol/l
5.81
107
402
150
683
2.68
21.18
3.3
2.2
—
—
—
0
0
61
167
4.01
20.06
3.1
3.4
445.06
282.58
mg/l
0.78
36
65
181
926
2.46
19.84
7.8
2.9
510.41
535.66
mosm/kgh2o
1.04
170
809
258
1554
2.31
19.33
9.8
3.4
30.54
107.96
e6/l
1.11
227
1195
70
218
3.55
19.09
1.2
1.3
—
—
—
0
0
239
1422
2.26
18.12
11.0
4.1
7.40
7.40
ph
1.75
190
1007
276
1743
2.24
18.06
11.5
3.9
53.93
110.70
e6/l
1.38
226
1239
36
70
5.45
17.94
5.8
2.3
4.48
4.62
e9/l
0.12
36
70
293
1902
2.24
17.83
7.0
3.6
6.45
6.22
ph
2.97
153
1079
239
1429
2.24
17.83
3.3
2.1
125.16
204.05
u/l
3.76
231
1350
28
44
6.67
17.27
2.6
2.1
—
—
—
0
0
344
2403
2.28
17.22
8.4
4.0
0.00
3.18
estimate
0.50
90
510
340
2381
2.24
16.67
8.5
3.9
0.01
0.00
estimate
0.38
88
498
247
1527
2.18
16.63
7.2
3.5
119.35
51.24
mg/l
2.79
180
988
101
422
2.73
16.54
11.3
8.6
—
—
—
0
0
254
1592
2.16
16.46
7.3
3.4
6.73
7.42
mmol/l
2.27
225
1321
185
1023
2.25
16.41
2.0
1.7
1.58
1.28
mg/l
0.56
155
814
211
1234
2.19
16.26
3.5
2.2
3.41
3.02
mg/l
0.85
186
1056
37
82
4.78
15.89
2.4
1.5
—
—
—
0
0
220
1329
2.14
15.42
9.6
3.3
0.24
0.47
e6/l
1.95
191
969
341
2432
2.17
15.39
8.6
4.0
0.00
0.02
estimate
0.93
88
475
40
97
4.38
15.39
1.7
1.2
98.53
1300.97
e6/l
0.50
34
74
244
1534
2.11
15.39
4.1
3.3
2067.80
1445.34
ng/l
1.23
222
1323
248
1569
2.11
15.38
9.2
4.1
28.24
8.70
mg/mmol
3.56
179
968
39
96
4.31
14.72
1.6
1.2
272.31
15.31
e6/l
0.47
32
68
121
589
2.37
14.23
7.8
8.2
7.42
7.41
ph
0.25
71
349
110
513
2.45
14.22
8.0
3.6
7.37
7.39
ph
1.36
71
289
146
771
2.24
14.17
1.4
1.3
33.22
40.03
iu/ml
0.38
44
229
346
2527
2.10
14.06
6.8
6.5
10.09
11.48
umol/l
2.72
339
2409
36
87
4.37
13.90
1.8
1.2
—
—
—
0
0
107
498
2.45
13.87
8.0
3.5
1.51
1.85
mmol/l
0.42
101
428
38
96
4.19
13.86
5.8
2.4
62.00
58.93
%
0.73
38
96
115
554
2.38
13.81
4.0
3.1
4.94
5.82
e9/l
0.35
101
481
120
591
2.34
13.69
7.9
8.2
4.82
5.07
kpa
1.99
115
572
120
592
2.34
13.63
7.9
8.1
11.91
11.85
kpa
0.04
115
575
34
80
4.48
13.58
4.8
3.2
17.82
9.37
pmol/l
0.57
34
80
23
38
6.29
13.50
2.0
2.9
772.30
924.92
mg
0.24
23
38
118
582
2.33
13.39
8.0
8.3
0.82
0.90
mmol/l
0.08
95
481
315
2246
2.02
13.38
25.5
15.0
1.33
1.27
inr
0.85
267
1854
297
2077
2.00
13.30
5.7
3.1
169.35
129.31
ug/l
2.93
281
1918
171
982
2.10
13.30
13.1
4.9
—
—
—
0
0
66
251
2.87
12.78
5.8
3.7
—
—
—
0
0
430
3484
2.35
12.51
18.2
8.2
81.07
79.81
u/l
0.21
425
3294
147
815
2.12
12.41
1.8
1.7
1287.36
1188.32
nmol/l
0.48
125
623
31
73
4.45
12.36
2.0
1.5
158.67
164.05
au/ml
—
6
26
25
50
5.20
12.06
1.0
1.2
—
—
—
0
0
79
342
2.54
11.86
6.3
3.6
7.42
7.42
ph
0.00
67
282
23
44
5.42
11.64
1.3
1.1
—
—
—
0
0
34
92
3.88
11.31
1.3
1.1
—
—
—
0
0
23
28
8.54
10.91
1.1
1.0
—
—
—
0
0
58
225
2.78
10.80
2.9
2.3
0.00
0.02
estimate
0.49
16
59
128
712
2.06
10.52
1.4
1.3
7.79
15.04
u/ml
0.59
47
264
135
766
2.03
10.50
6.7
3.1
3.51
2.13
e6/l
0.79
87
379
18
15
12.38
10.41
1.6
1.5
—
—
—
0
0
205
1345
1.87
10.33
8.8
3.9
0.00
0.01
estimate
0.74
80
459
27
66
4.26
10.28
2.0
3.3
—
—
—
0
0
108
570
2.13
10.17
1.9
1.5
—
—
—
0
0
25
58
4.48
10.16
2.8
2.4
1.20
1.25
g/24h
0.04
18
35
22
46
4.95
10.10
3.4
4.0
—
—
—
0
0
352
2742
1.88
10.04
8.7
5.2
6.96
6.75
mmol/l
0.77
342
2607
276
1998
1.81
9.99
27.2
11.0
0.02
0.00
e9/l
0.47
247
1619
216
1452
1.83
9.99
4.0
3.3
—
—
—
0
0
21
26
8.37
9.92
1.2
1.2
—
—
—
0
0
29
77
3.93
9.90
1.5
1.2
224.00
270.73
u/ml
0.44
21
44
14
7
20.50
9.85
2.6
1.6
33.86
37.14
%
—
14
7
21
45
4.82
9.37
1.7
1.1
—
—
—
0
0
19
38
5.15
9.16
1.1
1.2
—
—
—
0
0
22
51
4.46
8.95
1.1
1.3
—
—
—
0
0
19
39
5.02
8.90
1.6
1.1
—
—
—
0
0
120
692
1.95
8.76
10.8
6.8
103.22
104.18
mmol/l
1.08
120
692
20
44
4.69
8.66
1.8
1.1
—
—
—
0
0
19
40
4.89
8.65
1.2
1.1
—
—
—
0
0
36
121
3.12
8.64
1.4
1.2
—
—
—
0
0
369
2986
1.81
8.52
8.7
4.8
159.88
2355.74
e6/l
—
8
46
65
300
2.33
8.42
1.8
1.7
—
—
—
0
0
17
20
8.75
8.36
1.2
2.3
—
—
—
0
0
20
46
4.48
8.21
1.1
1.2
—
—
—
0
0
84
437
2.10
8.12
2.9
2.2
0.00
0.04
estimate
0.49
16
75
13
10
13.29
7.91
5.7
4.2
—
—
—
0
0
199
1379
1.72
7.83
13.5
6.1
—
—
—
0
0
26
77
3.50
7.62
3.8
3.2
—
—
—
0
0
20
49
4.20
7.60
1.2
2.7
—
—
—
0
0
252
1875
1.67
7.50
5.8
3.9
59.11
59.11
ng/l
0.00
199
1385
21
54
4.01
7.50
1.1
1.2
—
—
—
0
0
12
9
13.61
7.41
6.1
5.2
60.25
40.83
%
—
12
9
17
25
6.99
7.34
1.3
1.1
—
—
—
0
0
208
1481
1.67
7.27
3.1
2.6
59.68
61.55
u/l
0.14
202
1375
22
61
3.72
7.10
1.1
1.1
—
9.76
—
0
16
20
53
3.88
6.87
1.2
1.2
—
—
—
0
0
15
21
7.32
6.74
1.4
1.2
0.71
0.50
ratio
—
7
10
27
90
3.11
6.59
6.4
3.0
2.41
2.75
mmol/l
0.30
22
57
17
42
4.15
6.40
1.5
1.3
58.09
68.93
%
0.41
11
30
25
82
3.15
6.28
1.5
1.6
—
—
—
0
0
10
8
12.71
6.10
1.1
1.0
—
—
—
0
0
32
126
2.64
5.82
4.3
3.1
0.88
2.01
index
1.15
17
70
28
103
2.82
5.79
6.4
3.0
—
—
—
0
0
21
65
3.32
5.78
1.3
1.4
—
—
—
0
0
21
65
3.32
5.78
1.3
1.4
—
—
—
0
0
21
65
3.32
5.78
1.3
1.4
—
—
—
0
0
21
65
3.32
5.78
1.3
1.4
—
—
—
0
0
12
16
7.65
5.66
1.1
1.0
—
—
—
0
0
12
16
7.65
5.66
1.1
1.0
—
—
—
0
0
12
16
7.65
5.66
1.1
1.0
—
—
—
0
0
9
7
13.05
5.60
1.4
1.3
—
—
—
0
0
16
42
3.90
5.57
1.0
1.1
—
—
—
0
0
66
360
1.95
5.56
3.2
3.4
239.80
233.10
ng/l
0.04
60
326
234
1798
1.55
5.56
8.9
3.9
0.00
0.05
estimate
2.36
76
415
23
78
3.04
5.48
1.9
1.4
—
—
—
0
0
219
1665
1.54
5.42
4.0
3.4
2.31
2.36
mmol/l
3.94
204
1509
29
113
2.66
5.39
1.9
1.5
3275.05
17647.90
e6/l
1.88
22
84
91
556
1.77
5.38
2.8
2.3
170.15
121.88
ug/g
0.95
82
441
62
335
1.97
5.37
7.0
3.1
117.42
128.01
g/l
2.98
62
326
48
236
2.14
5.36
7.9
3.6
24.27
25.11
mmol/l
0.94
48
226
203
1525
1.54
5.27
4.4
2.5
—
—
—
0
0
175
1286
1.54
4.96
7.8
3.3
0.69
0.02
estimate
0.47
72
399
41
196
2.19
4.91
2.2
2.6
—
—
—
0
0
11
17
6.58
4.79
1.1
1.2
—
—
—
0
0
27
109
2.56
4.70
1.4
1.2
—
—
—
0
0
148
1061
1.55
4.64
8.2
4.1
1.02
1.02
kg/l
0.54
112
718
7
5
14.16
4.58
1.1
1.2
—
—
—
0
0
196
1505
1.49
4.41
4.2
3.3
39.91
33.42
u/l
0.57
191
1423
10
16
6.35
4.31
2.1
1.6
—
—
—
0
0
8
9
9.00
4.29
1.0
1.2
—
—
—
0
0
7
6
11.80
4.28
1.3
1.0
—
—
—
0
0
7
6
11.80
4.28
1.3
1.0
9.07
6.13
mg/g
—
7
6
29
127
2.36
4.28
1.7
1.2
—
67.78
—
0
9
11
21
5.33
4.16
1.1
1.0
—
—
—
0
0
54
305
1.86
4.12
7.5
2.5
1.20
1.21
%
0.03
54
305
12
26
4.70
4.08
1.1
1.0
—
—
—
0
0
8
10
8.10
4.07
1.0
1.0
—
—
—
0
0
8
10
8.10
4.07
1.0
1.1
—
—
—
0
0
53
299
1.86
4.06
7.6
2.5
0.61
0.63
%
0.29
53
299
72
447
1.71
4.01
8.8
4.4
7.36
7.34
ph
0.78
63
320
32
151
2.19
3.99
1.3
1.3
34.18
26.39
iu/l
0.60
24
128
254
2088
1.42
3.83
2.6
2.2
94.90
95.14
pmol/l
0.03
142
1117
130
942
1.51
3.80
4.9
4.2
192.85
342.30
ng/l
0.96
111
760
82
544
1.60
3.54
2.8
2.8
8.53
7.12
umol/l
0.31
70
480
13
38
3.48
3.33
1.0
1.1
103.15
101.13
pmol/l
0.06
13
38
180
1424
1.40
3.25
2.1
1.7
19.45
20.47
nmol/l
0.38
164
1191
18
72
2.55
3.24
1.2
1.0
—
—
—
0
0
65
421
1.62
3.09
1.5
1.5
—
—
—
0
0
8
16
5.06
3.06
1.1
1.3
121.63
167.67
mmol/24h
—
8
16
127
957
1.43
2.98
1.9
1.8
435.00
7170251.32
pmol/l
0.50
112
795
20
88
2.32
2.97
3.4
3.4
0.68
0.78
nmol/l
0.63
14
77
9
22
4.14
2.89
1.0
1.0
1087.11
1610.41
miu/ml
—
9
22
7
13
5.44
2.87
1.4
1.5
—
—
—
0
0
7
13
5.44
2.87
1.1
1.1
—
—
—
0
0
7
13
5.44
2.87
1.0
1.2
—
—
—
0
0
6
9
6.73
2.87
1.3
3.0
—
—
—
0
0
78
539
1.53
2.82
1.5
1.3
—
—
—
0
0
18
78
2.35
2.77
1.1
1.1
—
—
—
0
0
5
6
8.40
2.75
1.2
1.2
—
—
—
0
0
217
1807
1.34
2.75
2.5
2.2
—
—
—
0
0
11
34
3.28
2.74
1.5
1.6
7.95
8.01
mmol/l
0.02
11
34
132
1016
1.40
2.74
1.4
1.3
1.40
1.77
u/ml
0.18
38
279
56
363
1.61
2.67
13.2
3.6
—
—
—
0
0
145
1156
1.35
2.40
4.2
2.5
—
—
—
0
0
61
417
1.52
2.34
2.5
2.4
5.28
7.49
ug/l
0.92
52
369
10
34
2.98
2.29
1.4
1.6
17.10
16.16
%
—
10
34
7
18
3.93
2.26
1.0
1.2
—
—
—
0
0
5
9
5.60
2.22
2.0
2.1
—
—
—
0
0
22
115
1.95
2.19
2.4
2.5
161.80
101.92
ug/min
0.29
15
66
455
4301
1.46
2.18
47.6
16.6
26.19
24.23
mg/l
0.74
439
3575
36
222
1.67
2.12
1.5
1.3
—
—
—
0
0
14
62
2.29
2.09
1.9
1.8
—
—
—
0
0
5
10
5.04
2.07
1.2
1.1
—
—
—
0
0
245
2141
1.27
2.00
4.4
2.9
—
—
estimate
—
0
0
323
2926
1.27
1.93
4.2
3.3
57.83
52.59
u/l
0.56
311
2742
13
58
2.27
1.92
3.2
1.7
10.25
10.43
%
0.06
13
58
25
144
1.77
1.88
1.8
1.4
313.44
275.24
ug/g
0.65
18
87
9
35
2.60
1.81
1.8
1.3
—
—
—
0
0
30
185
1.66
1.79
1.5
1.5
0.31
0.30
mg/l
0.02
14
81
7
24
2.94
1.72
1.6
1.7
90.43
79.38
umol/l
—
7
24
20
111
1.83
1.71
1.2
1.2
14.32
10.27
u/l
0.34
13
89
49
346
1.46
1.65
1.3
1.2
—
—
—
0
0
361
3345
1.26
1.64
4.7
4.2
15.17
14.88
pmol/l
1.35
340
3022
5
14
3.60
1.62
1.2
1.1
—
—
—
0
0
7
26
2.71
1.58
1.0
1.9
—
—
—
0
0
5
15
3.35
1.52
1.4
1.2
—
—
—
0
0
80
624
1.33
1.52
1.3
1.3
—
—
—
0
0
7
27
2.61
1.52
6.0
2.7
0.29
0.93
index
—
7
27
21
340
0.60
1.49
1.3
1.4
—
—
—
0
0
11
52
2.14
1.45
2.5
1.4
—
—
—
0
0
120
997
1.26
1.43
3.1
2.8
2.47
2.45
mmol/l
0.60
109
896
7
29
2.43
1.39
3.4
1.7
77.21
54.12
ug/l
—
7
29
5
122
0.40
1.39
1.2
1.3
—
—
—
0
0
55
411
1.38
1.38
1.3
1.4
—
—
—
0
0
34
472
0.70
1.20
1.5
1.7
—
—
—
0
0
38
276
1.41
1.15
1.5
1.2
76.93
157.07
u/ml
1.95
19
110
7
30
2.35
1.12
1.0
1.1
—
—
—
0
0
15
89
1.71
1.08
1.5
1.2
82.64
37.74
u/l
0.47
15
77
185
1655
1.18
1.05
5.2
3.8
—
0.83
—
0
6
11
60
1.85
1.03
1.3
1.3
0.84
0.60
nmol/l
0.71
11
55
403
4193
0.83
1.01
6.0
5.3
6.04
6.00
mmol/l
0.17
379
3815
15
92
1.65
0.98
2.0
2.0
4501.93
7246.53
u/l
—
9
33
0
30
0.00
0.97
0.0
2.1
—
6.94
—
0
23
12
69
1.76
0.97
3.8
2.0
29.92
32.59
pg
0.88
12
69
10
54
1.87
0.97
1.8
2.1
—
—
—
0
0
10
54
1.87
0.97
1.3
1.3
—
—
nmol/l
—
0
0
375
3568
1.18
0.96
49.5
20.6
14.45
13.71
%
13.96
375
3537
6
27
2.24
0.93
2.5
1.8
98.83
118.90
ng/l
—
6
27
13
79
1.66
0.88
2.1
1.4
—
—
—
0
0
10
56
1.80
0.88
2.3
1.5
—
—
—
0
0
6
30
2.01
0.87
1.7
1.3
111.87
181.32
pmol/l
—
6
30
8
47
1.71
0.81
1.3
1.1
—
—
—
0
0
29
216
1.36
0.80
3.1
1.9
—
—
—
0
0
0
26
0.00
0.78
0.0
1.1
—
—
—
0
0
46
369
1.27
0.77
4.1
2.9
5.97
6.09
ph
0.49
37
252
46
369
1.27
0.77
1.4
1.4
—
—
—
0
0
415
4008
1.18
0.76
5.9
5.3
1.90
1.94
mu/l
0.22
393
3661
5
26
1.93
0.71
1.0
1.0
—
—
—
0
0
423
4099
1.17
0.71
8.8
6.7
40.87
39.64
mmol/mol
1.74
411
3828
451
4405
1.18
0.61
33.9
15.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
132.10
—
0
21
6
35
1.72
0.58
1.0
1.2
279.33
369.30
nmol/l
—
6
30
12
172
0.69
0.57
1.4
1.7
—
—
—
0
0
27
212
1.29
0.56
1.1
1.1
—
—
—
0
0
394
4054
0.88
0.56
5.5
4.4
1.36
1.28
mmol/l
1.37
372
3691
5
90
0.55
0.56
1.6
1.6
—
—
—
0
0
6
38
1.59
0.54
1.0
1.0
—
—
—
0
0
9
62
1.46
0.53
2.8
1.4
—
—
—
0
0
9
63
1.44
0.52
1.0
1.1
—
—
—
0
0
9
63
1.44
0.52
1.0
1.1
—
—
—
0
0
148
1595
0.90
0.50
3.6
3.3
—
—
—
0
0
17
128
1.34
0.48
5.4
5.0
—
—
—
0
0
27
218
1.25
0.47
2.9
2.5
—
—
—
0
0
7
48
1.46
0.47
3.6
2.8
—
—
—
0
0
24
293
0.81
0.41
1.8
1.8
3.28
3.47
mmol/l
0.48
17
224
5
33
1.52
0.41
1.6
1.3
7.33
7.37
ph
—
5
24
416
4239
0.91
0.37
6.2
5.1
1.47
1.46
mmol/l
0.15
394
3896
9
70
1.29
0.37
5.4
2.7
4.06
4.07
mmol/l
—
9
70
9
70
1.29
0.37
5.4
2.7
106.00
105.49
mmol/l
—
9
70
6
45
1.34
0.34
1.0
1.3
23.17
30.98
ng/l
—
6
45
15
118
1.28
0.34
2.2
1.4
—
—
—
0
0
97
901
1.09
0.31
3.1
3.2
0.69
0.78
ug/l
0.51
68
592
15
120
1.26
0.30
1.0
1.1
—
—
—
0
0
7
55
1.28
0.30
1.9
2.1
—
—
—
0
0
419
4255
0.92
0.28
6.2
5.2
4.46
4.57
mmol/l
1.38
395
3940
25
289
0.86
0.27
1.4
1.2
—
—
—
0
0
13
104
1.26
0.26
2.2
1.3
—
—
—
0
0
25
218
1.15
0.23
1.2
1.1
—
118.50
—
0
6
5
38
1.32
0.23
1.6
1.2
—
—
—
0
0
428
4333
0.93
0.23
6.8
6.0
2.50
2.66
mmol/l
3.51
410
3989
15
125
1.21
0.22
2.3
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
8.79
—
0
5
0
12
0.00
0.21
0.0
1.4
—
0.00
—
0
12
15
126
1.20
0.21
2.4
1.4
—
—
—
0
0
15
126
1.20
0.21
2.3
1.4
—
—
—
0
0
15
126
1.20
0.21
2.3
1.4
—
—
—
0
0
16
136
1.18
0.20
1.8
1.2
—
—
—
0
0
8
69
1.16
0.16
6.0
2.7
1.22
1.19
mmol/l
—
8
69
11
92
1.20
0.16
2.9
1.5
—
—
—
0
0
10
118
0.84
0.14
1.0
1.1
—
0.73
—
0
18
11
128
0.86
0.13
1.0
1.1
0.86
0.93
g/l
0.34
11
128
10
85
1.18
0.12
1.2
1.1
—
—
—
0
0
182
1860
0.97
0.12
2.0
1.9
1.38
1.33
mmol/l
0.27
161
1540
16
143
1.12
0.11
1.1
1.1
—
—
—
0
0
40
377
1.07
0.11
2.3
2.4
13.51
13.44
nmol/l
0.02
33
339
64
615
1.05
0.10
1.5
1.3
—
—
—
0
0
53
507
1.05
0.09
2.7
4.4
77.78
32.13
ug/l
0.26
43
427
6
58
1.03
0.08
1.2
1.2
—
—
—
0
0
14
154
0.91
0.08
15.8
10.6
—
—
—
0
0
11
123
0.89
0.08
1.0
1.1
1.59
1.56
g/l
0.10
11
123
8
74
1.08
0.07
1.1
1.9
—
—
—
0
0
126
1242
1.02
0.04
1.5
1.4
—
—
—
0
0
155
1542
1.01
0.01
4.7
5.7
2.46
2.59
ug/l
0.10
135
1366
0
5
0.00
-0.00
0.0
1.8
—
0.52
—
0
5
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
6860.88
—
0
8
0
7
0.00
-0.00
0.0
1.3
—
1.95
—
0
7
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
18.30
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_NECROVASCNAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_NECROVASCNAS 2.738 [2.25, 3.33] < 0.001
Birth year 0.994 [0.99, 1.0] 0.152

During the follow-up period (1.1.1998 — 31.12.2019), 421 out of 1141 females with M13_NECROVASCNAS died.

Males

Parameter HR [95% CI] p-value
M13_NECROVASCNAS 2.719 [2.19, 3.38] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 382 out of 930 males with M13_NECROVASCNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_NECROVASCNAS.

N-year risk Females Males
1 0.155% 0.461%
5 1.405% 3.089%
10 3.493% 7.542%
15 7.111% 14.245%
20 12.552% 22.975%

Relationships between endpoints

↥

Index endpoint: M13_NECROVASCNAS – Other specified/unspecified necrotizing vasculopathies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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