No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
89 |
4. Check minimum number of eventsNone |
89 |
5. Include endpointsNone |
89 |
6. Filter based on genotype QC (FinnGen only) |
83 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M12
- Name in latin
- Hydrarthrosis intermittens
Similar endpoints
↥List of similar endpoints to
Intermittent hydrarthrosis
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 574 | 323 | 250 |
| Only index persons | 546 | 312 | 234 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 42.37 | 44.04 | 40.33 |
| Only index persons | 41.74 | 43.43 | 39.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 83 | 49 | 34 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 44.67 | 42.36 | 48.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 86
- Matched controls
- 860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.4
ICD-10 Finland
Intermittent hydrarthrosis
+∞
80.2
64
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
53.5
25.0
29
8
7193F
ICD-9 Finland
Other and unspecified disorder of joint, Palindromic rheumatism[HYDRARTHROSIS INTERMITTENS, POLVI]
+∞
20.6
19
*
M25.4
ICD-10 Finland
Effusion of joint
136.9
20.6
21
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
256.7
20.5
20
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
20.3
20.3
31
23
M13.9
ICD-10 Finland
Arthritis, unspecified
72.7
20.0
22
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
18.4
17
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
17.3
16
*
A07EC01
ATC
sulfasalazine; oral, rectal
25.6
16.7
23
12
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
25.6
16.7
23
12
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
42.7
16.6
20
6
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
69.6
15.4
17
*
P01BA02
ATC
hydroxychloroquine; oral
44.8
15.1
18
5
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
+∞
15.0
14
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
15.0
14
*
M25.5
ICD-10 Finland
Pain in joint
5.8
14.3
38
103
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
21.7
13.2
19
11
L15
ICPC
Knee symptom/complaint
5.7
13.0
33
85
L01BA01
ATC
methotrexate; systemic
+∞
12.8
12
*
1220
FHL
Arthroscopy
35.8
12.1
15
5
L04AX03
ATC
methotrexate; systemic
14.9
12.1
20
17
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
15.9
11.8
19
15
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
137.7
11.7
12
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
11.7
11
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
41.5
9.3
11
*
L04AA13
ATC
[U] leflunomide
99.4
8.6
9
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
8.5
8
*
WX320
NOMESCO Finland
Spinalanesthesy
4.6
8.5
25
71
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.5
8.3
18
26
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
4.0
8.3
32
111
M19.0
ICD-10 Finland
Primary arthrosis of other joints
37.2
8.3
10
*
M01AH01
ATC
celecoxib; oral
4.9
8.2
21
53
M54.5
ICD-10 Finland
Low back pain
3.6
7.8
44
195
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
87.3
7.5
8
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
17.7
7.4
11
7
NG1DA
NOMESCO Finland
X-ray of knees
+∞
7.4
7
*
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
33.1
7.3
9
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
43.6
6.9
8
*
L88
ICPC
Rheumatoid/seropositive arthritis
24.8
6.8
9
*
L03
ICPC
Low back symptom/complaint
3.4
6.7
34
139
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
12.4
6.5
11
10
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
+∞
6.3
6
*
1222
FHL
Arthroscopy and synovial surgery
+∞
6.3
6
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
+∞
6.3
6
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
6.3
6
*
L04AB01
ATC
etanercept; parenteral
+∞
6.3
6
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
+∞
6.3
6
*
M25.0
ICD-10 Finland
Haemarthrosis
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
17
5
41.69
14.11
1.6
1.0
—
—
—
0
0
31
95
4.54
9.64
1.5
1.2
29.42
1.67
u/ml
0.86
15
42
31
113
3.73
7.37
1.3
1.2
19.11
17.64
iu/ml
0.10
13
31
40
215
2.61
4.50
5.7
3.8
0.00
0.01
estimate
0.49
21
81
7
6
12.54
4.35
1.1
1.0
—
—
—
0
0
71
521
3.08
4.01
8.4
3.2
10.72
10.69
mm/h
0.01
65
475
49
310
2.35
3.66
5.6
3.5
0.00
0.07
estimate
1.02
18
72
57
386
2.41
3.63
5.9
3.7
0.00
0.00
estimate
-0.00
23
83
57
387
2.40
3.59
5.9
3.7
0.00
0.00
estimate
-0.00
23
81
40
234
2.33
3.56
5.6
2.9
0.00
0.00
estimate
-0.00
18
65
57
389
2.38
3.52
6.0
3.7
0.00
0.05
estimate
0.68
21
76
59
419
2.30
3.18
10.1
10.7
3.53
4.14
e9/l
1.70
54
368
27
139
2.37
3.16
1.9
1.8
412.14
99153007.64
pmol/l
0.50
21
118
46
298
2.17
3.08
3.4
2.6
—
—
estimate
—
0
0
7
12
6.24
3.08
1.1
1.5
—
—
—
0
0
17
71
2.74
3.03
2.0
3.3
—
—
—
0
0
8
18
4.78
2.87
1.3
1.6
—
—
—
0
0
72
575
2.55
2.69
5.1
4.3
14.80
14.86
pmol/l
0.06
64
528
81
707
3.50
2.46
25.4
15.2
20.91
23.32
mg/l
0.34
70
558
6
14
4.52
2.19
1.0
1.9
—
—
—
0
0
5
10
5.23
2.10
1.6
4.0
6.98
11.76
pmol/l
—
5
10
5
10
5.23
2.10
1.6
2.8
17.76
16.82
%
—
5
10
80
708
2.86
2.03
7.0
6.1
38.92
38.96
mmol/mol
0.01
72
658
80
712
2.77
1.87
4.8
4.2
1.32
1.31
mmol/l
0.06
71
663
44
318
1.79
1.86
1.9
1.8
1.43
1.32
mmol/l
0.38
30
252
18
101
1.99
1.64
1.9
1.8
1311.08
1133.79
nmol/l
0.31
12
74
77
685
2.18
1.51
6.3
5.2
1.89
1.96
mu/l
0.24
71
625
9
40
2.39
1.45
1.6
2.6
—
—
—
0
0
5
17
3.06
1.38
1.0
1.4
—
—
—
0
0
5
17
3.06
1.38
1.2
1.9
—
—
—
0
0
5
17
3.06
1.38
1.2
1.6
—
—
—
0
0
26
174
1.71
1.37
1.4
1.3
0.89
1.37
u/ml
—
7
60
37
274
1.61
1.32
7.1
3.8
17.32
20.54
ng/l
0.41
27
184
9
44
2.17
1.31
6.2
8.4
1.89
1.64
%
—
9
44
30
212
1.64
1.28
3.5
3.3
537.28
961.60
ng/l
1.46
20
185
63
536
1.66
1.23
3.4
2.9
37.79
45.62
u/l
0.81
58
509
39
297
1.57
1.22
2.3
2.0
110.88
97.22
pmol/l
0.88
25
162
20
130
1.70
1.16
1.8
1.4
—
—
—
0
0
31
230
1.54
1.06
4.5
3.9
10.76
8.62
mg/mmol
0.13
18
143
7
35
2.09
1.02
1.3
2.6
—
—
—
0
0
25
181
1.54
0.94
3.8
4.8
21.82
21.51
%
0.03
13
92
8
42
2.00
0.91
6.3
8.5
0.69
0.70
%
—
8
42
27
201
1.50
0.90
3.6
2.8
0.07
0.37
e6/l
1.84
22
136
8
45
1.86
0.87
6.9
7.5
23.99
24.76
mmol/l
—
8
45
6
32
1.94
0.83
3.3
2.6
1.73
1.31
%
—
6
32
0
24
0.00
0.80
0.0
2.0
—
—
—
0
0
0
24
0.00
0.80
0.0
1.5
—
—
—
0
0
0
25
0.00
0.80
0.0
2.4
—
—
—
0
0
42
351
1.38
0.73
6.0
7.8
1.22
1.21
mmol/l
0.34
32
299
7
41
1.77
0.72
1.7
1.8
—
—
—
0
0
14
97
1.53
0.64
8.6
7.0
106.57
104.13
mmol/l
1.71
14
97
18
132
1.46
0.64
3.6
2.9
0.64
0.76
ug/l
0.66
11
82
78
738
1.61
0.60
23.0
17.4
3.95
3.96
mmol/l
0.19
78
724
78
736
1.64
0.60
22.9
17.2
140.13
139.86
mmol/l
0.53
78
722
6
37
1.67
0.57
2.8
1.2
—
—
—
0
0
32
269
1.30
0.50
3.6
3.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
0
17
0.00
0.41
0.0
2.1
—
0.64
—
0
10
66
618
1.29
0.40
30.7
18.4
13.79
13.57
%
0.61
66
612
6
45
1.36
0.34
1.2
1.0
—
—
—
0
0
26
224
1.23
0.32
2.8
2.2
58.04
58.22
u/l
0.01
26
208
9
73
1.26
0.26
1.8
1.9
—
—
—
0
0
9
74
1.24
0.26
2.1
1.9
—
—
—
0
0
11
87
1.30
0.26
2.1
1.9
—
—
—
0
0
50
467
1.17
0.24
3.3
3.1
—
—
—
0
0
13
108
1.24
0.21
1.6
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
20.88
—
0
5
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
14
118
1.22
0.20
3.7
2.5
1.30
0.78
e6/l
—
9
57
13
111
1.20
0.17
3.8
2.8
2.09
1.78
e6/l
—
8
51
8
70
1.16
0.17
1.9
1.9
—
—
—
0
0
17
153
1.14
0.12
3.3
2.3
—
—
—
0
0
12
106
1.15
0.10
1.4
1.5
—
—
—
0
0
16
157
1.02
0.00
5.1
3.9
1.02
1.02
kg/l
0.03
11
100
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
211.83
—
0
6
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
165.50
—
0
6
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
7
77
0.90
-0.00
6.9
6.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_INTERHYDRARTHR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_INTERHYDRARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_INTERHYDRARTHR – Intermittent hydrarthrosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data