No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
349 |
4. Check minimum number of eventsNone |
349 |
5. Include endpointsNone |
349 |
6. Filter based on genotype QC (FinnGen only) |
309 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Heberden's nodes [with arthropathy]
based on the number of shared cases.
Similar with more cases:
- Polyarthrosis
- Arthrosis
- Artrosis, including avohilmo
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 309 | 257 | 52 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.02 |
| Median age at first event (years) | 57.62 | 57.50 | 58.20 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 318
- Matched controls
- 3180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M15.1
ICD-10 Finland
Heberden nodes (with arthropathy)
+∞
307.7
318
*
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
5.1
17.8
40
87
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.2
15.7
74
274
M01AX05
ATC
glucosamine; oral
2.7
15.6
125
617
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.0
14.9
82
331
P01BA02
ATC
hydroxychloroquine; oral
3.4
14.5
59
199
ZXH06, ,
SPAT
4.4
14.1
38
96
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.3
13.7
58
200
M15.2
ICD-10 Finland
Bouchard nodes (with arthropathy)
146.0
13.6
14
*
ZYC01, ,
SPAT
3.3
12.8
53
180
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
5.4
11.9
24
47
M15.8
ICD-10 Finland
Other polyarthrosis
5.4
11.4
23
45
N03AX16
ATC
[U] pregabalin
2.3
10.9
109
581
ZYC01
NOMESCO Finland
Remote contact by phone
3.5
9.8
35
108
M01AB05
ATC
diclofenac; systemic, rectal
2.3
9.6
243
1844
M15.4
ICD-10 Finland
Erosive (osteo)arthrosis
12.0
9.2
16
14
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.7
9.2
54
223
M25.5
ICD-10 Finland
Pain in joint
2.1
9.0
137
850
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
5.0
8.7
19
40
WZC00, ,
SPAT
2.4
8.6
66
310
OAB42, ,
SPAT
2.5
8.4
62
285
M70.6
ICD-10 Finland
Trochanteric bursitis
2.3
8.4
80
412
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.9
8.4
41
153
M01AC06
ATC
meloxicam; systemic, rectal
2.0
8.3
160
1071
N02AX02
ATC
tramadol; systemic, rectal
2.0
7.9
165
1131
M01AH01
ATC
celecoxib; oral
2.1
7.7
86
470
A02BC02
ATC
pantoprazole; systemic
2.2
7.5
248
1976
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.2
7.4
73
379
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
7.1
7.4
17
25
M01AB16
ATC
aceclofenac; oral
3.9
7.2
21
56
UJF32
NOMESCO Finland
Coloscopy
2.0
7.1
106
644
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.4
7.0
53
246
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.9
6.7
32
118
A02BC03
ATC
lansoprazole; oral
1.9
6.6
117
747
NDG76
NOMESCO Finland
Fusion of DIP joint
10.3
6.6
12
12
H02AB06
ATC
prednisolone; systemic
1.8
6.4
171
1238
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
8.4
6.4
13
16
M54.5
ICD-10 Finland
Low back pain
1.8
6.2
133
899
L04AX03
ATC
methotrexate; systemic
2.4
6.2
46
212
WW200, ,
SPAT
1.8
6.1
123
816
R03AC02
ATC
salbutamol; inhalant
1.8
6.1
196
1495
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.0
128
861
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
119
624
2.45
12.63
1.4
1.3
52.87
36.72
iu/ml
0.47
47
194
111
569
2.46
12.33
1.4
1.3
5.76
10.22
u/ml
0.72
55
213
125
723
2.20
10.11
5.7
4.4
1.02
1.02
kg/l
0.32
73
486
38
132
3.13
8.78
1.2
1.3
7.09
3.01
u/ml
—
10
9
139
925
1.89
7.03
5.7
4.3
0.00
0.01
estimate
0.50
33
312
212
1635
1.89
6.55
5.3
4.2
0.00
0.00
estimate
-0.00
37
341
214
1658
1.89
6.49
5.3
4.3
0.00
0.02
estimate
0.80
36
322
209
1624
1.84
6.09
5.4
4.2
0.00
0.00
estimate
-0.00
34
335
167
1227
1.76
5.75
5.7
4.0
0.00
0.02
estimate
0.78
25
271
33
137
2.57
5.50
1.3
1.6
6.26
6.80
iu/ml
0.06
14
38
210
1698
1.70
4.68
9.1
10.0
3.74
3.89
e9/l
0.50
194
1475
259
2234
1.86
4.46
6.8
4.7
10.95
13.03
mm/h
2.71
251
2067
110
775
1.64
4.07
2.4
2.6
303.58
330.21
umol/l
2.48
100
664
25
110
2.38
3.72
1.2
1.4
1.20
1.24
g/l
0.28
25
105
15
52
2.98
3.51
1.2
1.3
—
—
—
0
0
180
1460
1.54
3.47
2.8
2.5
81.58
80.90
nmol/l
0.13
163
1297
141
1087
1.53
3.43
4.2
3.3
—
—
—
0
0
261
2323
1.69
3.21
8.2
8.4
74.97
80.32
u/l
2.10
250
2196
23
107
2.24
3.05
1.2
1.4
0.21
0.23
g/l
1.08
23
102
131
1019
1.49
2.94
2.9
2.4
55.96
71.91
u/l
1.41
122
930
22
108
2.11
2.58
1.5
1.3
1.22
3.31
u/ml
—
6
24
19
88
2.23
2.56
1.5
1.5
61.44
0.03
iu/ml
—
7
10
92
689
1.47
2.42
2.6
2.8
2.43
2.47
mmol/l
1.99
83
628
125
1001
1.41
2.27
3.2
3.2
771.44
1105.40
ng/l
0.80
115
852
145
1204
1.38
2.08
4.5
3.9
43.34
78.67
ng/l
0.30
105
904
19
98
2.00
2.00
1.1
1.2
—
—
—
0
0
5
11
4.60
1.95
2.6
2.2
60.40
61.61
ug/l
—
5
11
221
1986
1.37
1.81
6.2
5.0
177.00
3353.12
e6/l
—
5
34
92
724
1.38
1.80
1.4
1.3
1.47
1.32
u/ml
0.08
40
188
59
433
1.45
1.70
1.4
1.4
—
—
—
0
0
39
269
1.51
1.53
3.6
3.3
75.01
79.71
ng/l
0.17
33
230
39
269
1.51
1.53
1.9
2.4
0.46
0.52
e6/l
0.05
32
252
81
640
1.36
1.53
1.7
1.7
454.82
9579010.75
pmol/l
0.50
73
522
92
742
1.34
1.52
2.1
2.4
—
—
—
0
0
69
535
1.37
1.46
2.7
3.1
1.30
0.96
e6/l
0.26
44
280
17
95
1.83
1.46
1.3
1.2
1.02
11.89
u/ml
—
5
7
290
2766
1.55
1.41
6.6
6.9
39.36
39.55
mmol/mol
0.17
279
2581
13
67
1.98
1.40
1.3
1.3
—
—
—
0
0
135
1161
1.28
1.37
2.9
3.4
2.36
2.37
mmol/l
0.43
124
1055
94
771
1.31
1.37
3.0
2.2
3.16
3.05
mg/l
0.20
85
668
9
43
2.12
1.31
1.0
1.0
—
—
—
0
0
22
138
1.64
1.30
1.0
1.1
—
—
—
0
0
167
1483
1.27
1.28
7.0
5.9
1.21
1.22
mmol/l
0.22
161
1364
253
2368
1.33
1.27
5.2
4.8
14.96
14.93
pmol/l
0.06
243
2165
284
2708
1.46
1.26
6.3
6.0
1.96
1.94
mu/l
0.04
271
2478
101
848
1.28
1.22
3.7
3.4
0.21
0.46
e6/l
1.88
74
615
5
19
2.66
1.22
1.2
2.1
585.20
868.42
mg
—
5
19
6
26
2.33
1.19
1.0
1.1
—
—
—
0
0
0
34
0.00
1.16
0.0
1.1
—
—
—
0
0
8
40
2.03
1.13
1.1
1.4
—
—
—
0
0
290
2786
1.46
1.13
18.9
16.4
17.46
22.33
mg/l
2.51
245
2287
203
1869
1.24
1.04
3.3
3.2
40.33
49.13
u/l
1.13
188
1739
179
1627
1.23
1.04
6.8
6.7
1.22
1.22
mmol/l
0.12
162
1406
16
99
1.65
1.02
2.5
2.6
—
—
—
0
0
7
35
2.02
1.00
1.6
1.6
—
—
—
0
0
30
406
0.71
0.98
5.0
5.1
35.85
33.51
%
0.65
20
243
10
54
1.88
0.97
1.3
1.4
—
—
—
0
0
184
1686
1.22
0.95
5.0
6.6
9.59
10.50
umol/l
1.24
174
1600
6
27
2.24
0.94
1.2
1.3
—
—
—
0
0
6
115
0.51
0.84
1.7
1.5
—
—
—
0
0
156
1419
1.20
0.84
4.5
4.3
36.06
35.72
g/l
0.39
146
1330
36
277
1.34
0.83
3.9
2.6
4.26
4.32
kpa
0.08
36
270
34
261
1.34
0.80
1.3
1.4
—
—
—
0
0
6
33
1.83
0.79
2.0
2.6
1.82
2.92
nmol/l
—
6
33
0
25
0.00
0.79
0.0
1.6
—
—
—
0
0
0
26
0.00
0.79
0.0
1.1
—
—
—
0
0
111
987
1.19
0.75
2.2
2.1
297.58
159.99
u/l
0.38
106
931
5
24
2.10
0.75
1.0
1.2
117.80
109.04
pmol/l
—
5
24
148
1351
1.18
0.74
3.9
2.9
100.70
112.00
ug/l
0.59
142
1241
5
26
1.94
0.71
1.0
1.0
—
—
—
0
0
5
28
1.80
0.66
1.4
2.2
2.04
0.69
mmol/l
—
5
28
57
485
1.21
0.62
2.7
3.3
4.89
2.60
e6/l
0.58
32
232
5
30
1.68
0.61
1.2
1.3
—
—
—
0
0
13
185
0.69
0.60
2.1
1.7
—
—
—
0
0
5
89
0.55
0.56
3.2
1.6
93.80
95.80
%
—
5
84
105
952
1.15
0.55
1.9
1.6
24.54
21.88
nmol/l
0.82
97
791
150
1400
1.14
0.51
2.4
2.2
98.68
99.52
pmol/l
0.06
81
657
32
262
1.25
0.51
2.2
3.0
55.15
62.46
ml/min/173m2
0.52
13
109
121
1116
1.14
0.49
3.4
3.3
6.43
6.64
mmol/l
0.24
102
929
19
147
1.31
0.46
3.5
3.9
1.31
1.50
%
0.86
19
137
12
86
1.41
0.45
1.2
1.1
—
—
—
0
0
287
2810
1.22
0.44
5.4
5.6
5.92
5.96
mmol/l
0.25
278
2561
24
194
1.26
0.43
7.3
6.9
26.36
24.90
mmol/l
1.28
24
186
14
105
1.35
0.42
1.6
1.3
283.75
289.24
ug/g
—
8
67
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.8
—
1.22
—
0
18
46
402
1.17
0.40
4.1
4.6
0.99
1.06
mmol/l
0.97
39
363
265
2711
0.86
0.39
4.8
4.6
1.23
1.27
mmol/l
0.48
254
2474
44
502
0.86
0.39
1.9
1.9
—
—
—
0
0
301
2966
1.28
0.39
14.6
13.2
24.72
24.40
u/l
0.14
296
2886
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
119
1111
1.11
0.39
3.7
4.0
7.99
8.24
mg/mmol
0.03
70
638
9
66
1.37
0.38
2.0
2.8
8.91
9.69
pmol/l
—
9
66
19
152
1.27
0.38
1.4
1.5
—
—
—
0
0
37
319
1.18
0.38
4.4
3.3
5.87
5.85
kpa
0.06
37
311
12
90
1.35
0.36
1.8
1.4
—
—
—
0
0
5
79
0.63
0.36
3.0
1.7
—
—
—
0
0
48
426
1.15
0.35
7.1
6.4
103.54
103.91
mmol/l
0.23
48
426
107
999
1.11
0.35
2.9
2.9
29.92
30.24
u/l
0.05
97
933
128
1355
0.91
0.34
1.8
2.0
1.30
1.31
mmol/l
0.05
100
1104
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
11
82
1.35
0.34
3.5
2.5
0.44
0.43
iu/ml
—
5
47
93
864
1.11
0.33
4.5
3.6
0.00
0.00
estimate
-0.00
26
275
32
366
0.86
0.31
1.9
1.9
—
—
—
0
0
7
57
1.23
0.29
1.1
1.6
—
—
—
0
0
11
85
1.30
0.28
1.3
1.1
—
—
—
0
0
187
1807
1.08
0.27
4.5
4.8
6.51
6.62
mmol/l
0.38
181
1716
26
225
1.17
0.27
1.6
1.5
—
—
—
0
0
8
67
1.20
0.26
1.3
1.1
—
—
—
0
0
34
382
0.88
0.26
1.8
1.9
—
—
—
0
0
148
1419
1.08
0.26
2.9
2.6
—
—
estimate
—
0
0
15
123
1.23
0.26
2.3
1.5
—
—
—
0
0
5
39
1.29
0.23
1.2
1.2
—
94.40
—
0
5
7
92
0.76
0.23
8.9
4.0
26.40
25.65
mmol/l
—
7
87
10
79
1.27
0.22
1.4
1.7
—
—
—
0
0
10
79
1.27
0.22
4.5
3.3
1.00
1.79
index
—
5
47
281
2772
1.12
0.22
16.1
16.5
76.63
77.01
ml/min/173m2
0.14
269
2590
0
11
0.00
0.21
0.0
4.3
—
4.56
—
0
11
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
4.3
—
10.51
—
0
11
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
8
105
0.76
0.21
1.6
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
120.92
—
0
12
0
13
0.00
0.21
0.0
1.2
—
8.96
—
0
13
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
8.85
—
0
13
0
14
0.00
0.20
0.0
2.0
—
42.64
—
0
14
292
2889
1.13
0.20
6.8
6.5
2.67
2.73
mmol/l
0.57
281
2655
28
310
0.89
0.18
2.7
3.5
—
—
—
0
0
15
174
0.86
0.18
8.2
7.9
15.47
15.65
%
0.13
15
167
74
702
1.07
0.17
1.8
1.6
0.94
1.21
mg/l
0.80
64
570
24
215
1.13
0.17
1.9
2.7
—
24.75
—
0
11
23
206
1.13
0.16
1.1
1.2
149.47
139.79
u/ml
—
8
79
8
71
1.13
0.16
1.1
1.5
—
—
—
0
0
9
82
1.10
0.15
1.1
1.6
—
—
—
0
0
58
549
1.07
0.14
2.1
1.7
1330.50
1252.57
nmol/l
0.25
50
408
23
208
1.11
0.14
4.8
2.7
130.91
127.53
g/l
0.28
23
202
53
559
0.94
0.13
1.4
1.5
—
—
—
0
0
9
108
0.83
0.13
1.3
1.6
—
—
—
0
0
9
109
0.82
0.13
1.8
2.0
—
—
—
0
0
282
2844
0.93
0.13
5.7
5.6
4.68
4.76
mmol/l
0.76
272
2625
12
104
1.16
0.12
1.3
3.6
1.14
2.82
ratio
—
6
61
10
85
1.18
0.12
1.1
1.2
—
—
—
0
0
56
588
0.94
0.12
3.6
4.1
83.62
222.05
ng/l
0.97
42
468
39
368
1.07
0.11
6.1
7.3
11.99
12.15
kpa
0.08
39
356
39
368
1.07
0.11
6.1
7.3
5.25
5.17
kpa
0.22
39
356
142
1449
0.96
0.10
12.2
12.5
1.18
1.20
inr
0.10
123
1188
36
380
0.94
0.09
6.1
6.8
—
—
—
0
0
5
48
1.04
0.09
1.0
1.7
—
—
—
0
0
6
58
1.04
0.08
2.0
2.2
17.48
16.20
%
—
6
58
5
63
0.79
0.08
1.2
1.5
—
—
—
0
0
6
70
0.85
0.07
1.5
1.2
—
—
—
0
0
16
147
1.09
0.07
1.6
1.3
—
—
—
0
0
7
81
0.86
0.07
3.6
1.7
156.43
208.62
%
—
7
76
7
80
0.87
0.07
1.0
1.6
—
—
—
0
0
9
85
1.06
0.07
1.1
1.7
—
—
—
0
0
152
1539
0.98
0.05
2.7
2.6
—
—
—
0
0
19
179
1.07
0.05
5.2
2.3
0.80
0.61
%
1.67
19
179
12
111
1.08
0.04
2.5
1.4
—
—
—
0
0
282
2827
0.98
0.01
5.5
5.5
1.58
1.57
mmol/l
0.09
272
2595
10
94
1.07
0.01
2.0
1.7
5698.50
18967.42
e6/l
—
10
67
24
246
0.97
0.00
4.6
3.3
0.63
0.78
ug/l
0.63
16
163
10
102
0.98
0.00
1.8
1.5
—
—
—
0
0
11
107
1.03
0.00
1.1
1.3
—
—
—
0
0
32
323
0.99
0.00
5.4
4.9
23.94
21.70
%
0.30
16
166
31
307
1.01
0.00
6.5
7.9
121.00
118.66
g/l
0.25
31
301
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
7
78
0.90
-0.00
1.9
1.2
3.84
3.93
mmol/l
—
7
73
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
99
0.91
-0.00
1.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
1.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
60.87
—
0
6
5
50
1.00
-0.00
1.2
1.3
—
—
—
0
0
8
87
0.92
-0.00
1.6
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
-0.00
1.3
1.3
25.10
31.41
iu/l
—
7
61
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: M13_HEBERDENS_NODES – Heberden's nodes [with arthropathy]
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).