diffuse idiopathic skeletal hyperostosis: This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
561 |
4. Check minimum number of eventsNone |
561 |
5. Include endpointsNone |
561 |
6. Filter based on genotype QC (FinnGen only) |
502 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
- Name in latin
- Hyperostosis ancylopoetica
Similar endpoints
↥List of similar endpoints to
Ankylosing hyperostosis [Forestier]
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3079 | 1249 | 1805 |
| Only index persons | 2836 | 1179 | 1657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.05 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 58.00 | 58.94 | 57.26 |
| Only index persons | 57.53 | 58.39 | 56.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 502 | 205 | 297 |
| Unadjusted period prevalence (%) | 0.11 | 0.07 | 0.14 |
| Median age at first event (years) | 58.51 | 57.91 | 58.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 519
- Matched controls
- 5190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.1
ICD-10 Finland
Ankylosing hyperostosis [Forestier]
+∞
307.7
507
*
M48.0
ICD-10 Finland
Spinal stenosis
126.9
307.7
182
22
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
52.9
236.6
140
36
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
26.8
157.0
114
54
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
42.8
154.6
95
27
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
16.3
127.3
118
92
M54.6
ICD-10 Finland
Pain in thoracic spine
15.4
118.6
113
92
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
9.7
116.6
165
237
N03AX12
ATC
[U] gabapentin; oral
9.1
111.4
167
256
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
67.7
108.7
60
10
M47.82
ICD-10 Finland
Other spondylosis, cervical region
50.2
105.9
62
14
M54.5
ICD-10 Finland
Low back pain
6.6
102.5
277
770
N03AX16
ATC
[U] pregabalin
7.2
101.5
206
435
M54.4
ICD-10 Finland
Lumbago with sciatica
8.8
96.0
142
212
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
264.1
88.4
88
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
22.8
78.7
59
29
M54.9
ICD-10 Finland
Dorsalgia, unspecified
8.6
75.0
108
154
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
41.0
73.3
45
12
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
123.0
69.9
74
7
M43.1
ICD-10 Finland
Spondylolisthesis
32.8
68.8
45
15
N02AX02
ATC
tramadol; systemic, rectal
4.8
68.4
323
1323
L03
ICPC
Low back symptom/complaint
4.6
60.2
202
628
M47.9
ICD-10 Finland
Spondylosis, unspecified
127.8
54.0
57
5
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
17.1
51.8
44
28
N06AX21
ATC
duloxetine; oral
6.1
49.9
97
187
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.7
47.4
304
1432
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
12.5
45.3
46
40
L86
ICPC
Back syndrome with radiating pain
8.3
43.8
61
82
M53.1
ICD-10 Finland
Cervicobrachial syndrome
6.2
43.7
82
152
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
18.7
43.2
35
20
N02BF01
ATC
gabapentin; oral
5.7
40.7
84
170
M45
ICD-10 Finland
Ankylosing spondylitis
144.1
38.3
40
*
L02
ICPC
Back symptom/complaint
4.9
36.6
90
212
M03BX02
ATC
tizanidine; oral
3.4
36.1
362
2113
M54.2
ICD-10 Finland
Cervicalgia
6.6
35.8
61
102
M01AH05
ATC
etoricoxib; oral
3.5
35.6
382
2314
N02BF02
ATC
pregabalin; oral
6.5
34.7
60
102
M54.3
ICD-10 Finland
Sciatica
9.0
34.3
44
53
M54.8
ICD-10 Finland
Other dorsalgia
10.5
34.3
39
40
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
60.0
33.7
39
7
E66.01
ICD-10 Finland
Obesity due to excess calories
4.8
32.3
81
193
M03BC01
ATC
orphenadrine (citrate); systemic
3.4
31.1
139
500
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.0
30.8
197
874
N06AA09
ATC
amitriptyline; systemic
5.0
30.4
71
159
N02AJ06
ATC
codeine and paracetamol; systemic
2.8
28.6
260
1380
M01AH02
ATC
rofecoxib; oral
3.8
28.3
99
302
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
153.3
27.9
29
*
M01AH01
ATC
celecoxib; oral
3.3
27.5
126
457
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.0
27.3
167
716
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
8.3
26.7
36
46
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
24.8
26.5
37
16
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
26.3
25
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
3.6
26.2
102
333
G47.3
ICD-10 Finland
Sleep apnoea
2.8
26.1
177
799
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
273.5
25.9
26
*
M79.7
ICD-10 Finland
Fibromyalgia
10.2
25.2
29
30
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.8
25.0
84
248
SPAT1301
SPAT
No procedures
2.7
24.9
198
967
H02AB06
ATC
prednisolone; systemic
2.6
24.7
289
1699
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
4.6
24.2
61
145
M47.81
ICD-10 Finland
Other spondylosis, occipito-atlanto-axial region
91.1
23.9
26
*
M01AC06
ATC
meloxicam; systemic, rectal
2.5
23.4
226
1206
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.5
23.3
91
297
NF1AA
NOMESCO Finland
Hip X-ray examination
3.9
23.1
76
221
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
240.2
22.8
23
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.7
22.2
167
786
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
40.6
21.9
27
7
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
120.1
21.7
23
*
N02AA05
ATC
oxycodone; systemic
2.8
21.7
135
576
A02BC05
ATC
esomeprazole; systemic
2.4
21.3
242
1376
M25.5
ICD-10 Finland
Pain in joint
2.5
21.0
187
951
A07EC01
ATC
sulfasalazine; oral, rectal
4.2
20.9
59
153
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
6.1
20.5
37
65
M03BC51
ATC
orphenadrine, combinations; systemic
2.6
20.5
155
728
A02BC03
ATC
lansoprazole; oral
2.5
20.4
176
879
M79.1
ICD-10 Finland
Myalgia
3.2
20.3
94
339
M79.6
ICD-10 Finland
Pain in limb
2.4
20.1
243
1410
L13
ICPC
Hip symptom/complaint
2.8
20.1
126
538
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
20.0
192
1007
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
3.7
19.9
68
202
M54.1
ICD-10 Finland
Radiculopathy
17.3
19.9
31
19
E66.8
ICD-10 Finland
Other obesity
4.9
19.8
45
98
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.9
19.4
108
432
A02BC02
ATC
pantoprazole; systemic
2.6
19.1
389
2802
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
18.9
18
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
18.7
139
644
R52.2
ICD-10 Finland
Other chronic pain
6.5
18.7
31
50
N02BE01
ATC
paracetamol; systemic, rectal
4.8
18.3
489
4016
A10BA02
ATC
metformin; oral
2.3
18.2
208
1167
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.4
18.0
176
922
L04AX03
ATC
methotrexate; systemic
3.4
17.9
70
227
M01AB05
ATC
diclofenac; systemic, rectal
2.4
17.9
358
2522
C07AB07
ATC
bisoprolol; oral
2.2
17.2
303
2013
M77.1
ICD-10 Finland
Lateral epicondylitis
4.1
16.8
48
125
M01AE02
ATC
naproxen; oral, rectal
2.2
16.8
298
1977
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
16.8
16
*
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
+∞
16.8
16
*
M70.6
ICD-10 Finland
Trochanteric bursitis
3.0
16.5
79
289
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.5
16.4
60
186
C08CA01
ATC
amlodipine; oral
2.2
16.4
253
1585
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.5
16.4
59
181
UJF32
NOMESCO Finland
Coloscopy
2.3
16.4
167
885
T90
ICPC
Diabetes non-insulin dependent
2.3
16.4
179
977
A02BC01
ATC
omeprazole; systemic
2.3
16.2
158
821
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
5.2
16.2
34
69
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.3
16.1
164
868
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
16.0
168
901
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
15.9
292
1949
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
3.6
15.8
55
165
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.9
15.8
86
338
M01AX17
ATC
nimesulide; oral
2.3
15.6
146
744
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.6
15.6
105
460
SPAT1262
SPAT
Handing over of treatment supplies
2.5
15.6
125
595
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.1
15.6
72
258
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.2
15.5
175
965
L01
ICPC
Neck symptom/complaint
2.8
15.3
87
349
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
15.3
158
838
J01MA02
ATC
ciprofloxacin; systemic
2.1
15.3
224
1366
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.2
15.2
178
994
M13.9
ICD-10 Finland
Arthritis, unspecified
3.5
15.1
55
170
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
15.1
206
1222
205
Kela drug reimbursment
Chronic hypertension
2.2
15.0
178
999
J01DB01
ATC
cefalexin; oral
2.7
15.0
440
3510
L01BA01
ATC
methotrexate; systemic
5.9
14.8
27
48
B01AB05
ATC
enoxaparin; parenteral
2.1
14.7
193
1124
R5140
NOMESCO Finland
Monitoring the use of the aid
2.8
14.7
83
332
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.5
14.7
54
168
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
14.7
100
440
7216A
ICD-9 Finland
Spondylosis and allied disorders, Ankylosing vertebral hyperostosis
+∞
14.6
14
*
J01AA02
ATC
doxycycline; systemic
2.4
14.6
417
3259
M01AH03
ATC
valdecoxib; oral
4.0
14.4
43
116
SPAT1263
SPAT
Sampling
2.1
14.3
224
1392
S18
ICPC
Laceration/cut
2.0
14.2
273
1825
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.5
14.2
52
161
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.6
14.2
92
394
SPAT1153
SPAT
Removal of sutures
2.1
14.2
185
1072
A10BJ06
ATC
semaglutide; parenteral
3.6
14.2
50
151
A01
ICPC
Pain general/multiple sites
3.2
14.2
61
209
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.2
14.2
172
970
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
14.2
173
978
R03AC02
ATC
salbutamol; inhalant
2.0
14.2
282
1910
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
5.6
14.1
27
50
N06AX16
ATC
venlafaxine; oral
2.8
14.1
78
308
103
Kela drug reimbursment
Diabetes, insulin-treated
2.1
14.1
187
1091
M01AX05
ATC
glucosamine; oral
2.3
14.1
126
627
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.8
14.0
75
291
M50.3
ICD-10 Finland
Other cervical disc degeneration
18.2
13.9
21
12
L84
ICPC
Back syndrome without radiat pain
4.4
13.8
35
83
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
13.6
13
*
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
13.6
13
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.4
13.4
51
162
Z50.1
ICD-10 Finland
Other physical therapy
3.9
13.3
41
113
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.2
13.2
133
693
M43.0
ICD-10 Finland
Spondylolysis
41.2
13.2
16
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.6
13.0
85
365
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
13.0
104
491
N04BC05
ATC
pramipexole; oral
3.3
12.9
50
161
H02AB07
ATC
prednisone; oral
2.6
12.9
82
348
M79.0
ICD-10 Finland
Rheumatism, unspecified
10.0
12.9
25
26
M02AA07
ATC
piroxicam; topical
2.0
12.7
195
1192
R06.0
ICD-10 Finland
Dyspnoea
2.1
12.6
158
897
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
+∞
12.5
12
*
M01AC01
ATC
piroxicam; systemic, rectal
2.6
12.5
83
359
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
5.5
12.4
24
45
G44.2
ICD-10 Finland
Tension-type headache
2.8
12.4
67
261
A46
ICD-10 Finland
Erysipelas
2.4
12.4
99
467
J02AC01
ATC
fluconazole; systemic
2.0
12.3
175
1038
M19.8
ICD-10 Finland
Other specified arthrosis
4.2
12.3
33
82
SAA01
NOMESCO Finland
Simple examination of mouth
2.0
12.3
366
2798
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
12.2
111
553
L08
ICPC
Shoulder symptom/complaint
2.2
12.2
134
721
J01DA01
ATC
[U] cefalexin
2.0
12.2
316
2298
R53
ICD-10 Finland
Malaise and fatigue
2.2
12.1
132
708
N02AJ13
ATC
tramadol and paracetamol; systemic
9.6
12.1
24
26
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
21.9
12.1
17
8
J01FF01
ATC
clindamycin; systemic
2.1
12.0
155
887
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
5.6
11.9
23
43
NF1DA
NOMESCO Finland
X-ray of hips
6.0
11.9
21
36
N06AX11
ATC
mirtazapine; oral
2.0
11.8
174
1042
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.3
11.7
103
505
M01AX01
ATC
nabumetone; oral
4.4
11.7
30
72
R35
ICD-10 Finland
Polyuria
3.1
11.6
50
171
N02AC04
ATC
dextropropoxyphene; oral
4.8
11.5
26
56
L28
ICPC
Limited function/disability (L)
2.2
11.5
108
544
C10AA03
ATC
pravastatin; oral
3.0
11.5
55
200
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
11.5
129
698
NAG66
NOMESCO Finland
Posterior interbody fusion of lumbar spine, 2 vertebrae
+∞
11.5
11
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
11.5
11
*
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
11.5
11
*
P01BA02
ATC
hydroxychloroquine; oral
3.1
11.5
51
178
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.5
11.5
78
341
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
15.5
11.4
18
12
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
11.4
151
870
NA2AD
NOMESCO Finland
Thoracic spine CT examination
35.9
11.3
14
*
H02AB04
ATC
methylprednisolone; systemic
2.4
11.2
85
390
M01AB55
ATC
diclofenac, combinations; oral
3.3
11.2
43
137
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.9
11.1
234
1573
I10
ICD-10 Finland
Essential (primary) hypertension
2.0
11.1
361
2793
R20.2
ICD-10 Finland
Paraesthesia of skin
3.5
11.0
38
113
WX704
NOMESCO Finland
Intubation
3.1
11.0
49
171
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.2
10.9
44
145
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.1
10.9
135
758
L17
ICPC
Foot/toe symptom/complaint
2.0
10.6
162
976
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
11.6
10.6
19
17
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.6
10.6
36
106
A06AD11
ATC
lactulose; oral
2.3
10.5
86
408
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
112.2
10.5
11
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.2
10.5
42
138
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
+∞
10.4
10
*
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
+∞
10.4
10
*
9211
FHL
Exploration or removal of diskusprolapse
+∞
10.4
10
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
3.0
10.4
48
171
Z3226
NOMESCO Finland
Physiotherapist
2.2
10.3
96
481
SPAT1058
SPAT
PEF monitoring instruction
3.0
10.1
47
168
C03CA01
ATC
furosemide; systemic
1.9
10.1
175
1097
R03AC03
ATC
terbutaline; inhalant
2.4
10.1
75
341
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
7.9
10.0
22
29
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
10.0
215
1444
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.9
10.0
50
187
R52.9
ICD-10 Finland
Pain, unspecified
2.7
9.9
57
229
SPAT1202
SPAT
Intra-articular injection
4.7
9.9
23
51
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
9.8
39
127
J01FA06
ATC
roxithromycin; oral
1.8
9.8
202
1335
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.7
9.8
55
218
WX110
NOMESCO Finland
Infiltration anesthesia
1.9
9.8
360
2836
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
9.7
90
449
SAA02
NOMESCO Finland
Basic examination of mouth
1.8
9.7
323
2464
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
9.7
78
367
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
56.1
9.7
11
*
R42
ICD-10 Finland
Dizziness and giddiness
2.0
9.6
123
694
N06AA10
ATC
nortriptyline; systemic
8.6
9.6
20
24
L18
ICPC
Muscle pain
3.9
9.6
28
74
C01DA14
ATC
isosorbide mononitrate; oral
2.2
9.6
94
480
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
9.6
67
296
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
9.5
82
397
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.0
9.5
42
146
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
9.5
217
1479
C10AX09
ATC
ezetimibe; oral
2.0
9.4
114
631
M51.2
ICD-10 Finland
Other specified intervertebral disc displacement
+∞
9.4
9
*
M01AB01
ATC
indometacin; systemic, rectal
2.7
9.4
52
205
R05FB02
ATC
cough suppressants and expectorants; systemic
1.8
9.4
192
1264
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
9.4
194
1282
M53.0
ICD-10 Finland
Cervicocranial syndrome
3.0
9.4
41
142
G54.0
ICD-10 Finland
Brachial plexus disorders
9.8
9.3
18
19
N06AB04
ATC
citalopram; systemic
2.1
9.3
105
566
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
9.3
99
522
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
9.2
178
1150
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.1
9.2
40
138
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.9
9.2
27
72
KMAK, ,
NOMESCO Finland
1.8
9.1
242
1716
M54
ICD-10 Finland
Dorsalgia
2.6
9.1
55
227
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
37.4
9.0
11
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
9.0
223
1550
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.5
8.9
31
93
H02AB09
ATC
hydrocortisone; systemic
5.0
8.9
19
39
R03BA01
ATC
beclometasone; inhalant
2.3
8.9
70
326
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.9
8.9
26
69
E66.9
ICD-10 Finland
Obesity, unspecified
4.1
8.9
24
60
R01AD09
ATC
mometasone; nasal
1.8
8.9
213
1465
SFA10
NOMESCO Finland
One-surface restoration
1.7
8.9
272
2006
A02BA02
ATC
ranitidine; systemic
2.0
8.8
105
577
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
50.9
8.7
10
*
G56.2
ICD-10 Finland
Lesion of ulnar nerve
4.1
8.7
24
61
SPAT1310
SPAT
Counselling related to known health issue
1.8
8.6
157
992
E0000UV, ,
ATC
1.8
8.6
207
1420
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
3.6
8.6
28
80
M01AE01
ATC
ibuprofen; systemic, rectal
2.3
8.6
456
3958
J01DA08
ATC
[U] cefaclor
2.7
8.6
48
190
D10BA01
ATC
isotretinoin; oral
3.8
8.6
26
71
M54.0
ICD-10 Finland
Panniculitis affecting regions of neck and back
28.0
8.5
11
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.0
8.5
37
128
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.7
8.4
272
2023
G04BD09
ATC
trospium; oral
5.0
8.4
18
37
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.1
8.4
36
123
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
8.4
192
1297
M02AA10
ATC
ketoprofen; topical
2.1
8.4
85
439
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.8
8.4
43
163
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
+∞
8.4
8
*
XF402
NOMESCO Finland
ECG with work load test
2.3
8.3
66
308
N03AX09
ATC
lamotrigine; oral
4.3
8.3
21
50
R02
ICPC
Shortness of breath/dyspnoea
2.2
8.2
74
364
R06AE07
ATC
cetirizine; oral
1.7
8.2
197
1348
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.9
8.2
121
715
E66.00
ICD-10 Finland
Metabolic syndrome
2.8
8.1
40
148
A10BK01
ATC
dapagliflozin; oral
2.4
8.1
57
252
NA2AA, ,
SPAT
12.0
8.1
14
12
C10AA05
ATC
atorvastatin; oral
1.7
8.1
253
1859
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.9
8.1
38
137
R4110, ,
SPAT
2.1
8.1
79
402
J01DA09
ATC
[U] cefadroxil
1.8
8.1
136
837
R11
ICD-10 Finland
Nausea and vomiting
2.6
8.1
46
184
NA2BG, ,
SPAT
22.4
8.0
11
5
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.3
8.0
67
320
R13
ICD-10 Finland
Dysphagia
2.8
8.0
42
161
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.9
8.0
38
138
AA1AD
NOMESCO Finland
CT of head and brain
1.8
8.0
161
1046
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
3.6
7.9
26
75
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.4
7.9
29
90
K02.1
ICD-10 Finland
Caries of dentine
1.7
7.8
284
2164
M09AX01
ATC
hyaluronic acid; parenteral
3.2
7.8
31
101
M01AE51
ATC
ibuprofen, combinations; systemic
11.0
7.8
14
13
C10AC01
ATC
colestyramine; oral
4.3
7.8
20
48
R51.80
ICD-10 Finland
Headache
2.3
7.8
65
310
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
2.4
7.8
55
244
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.9
7.8
108
624
D07AC01
ATC
betamethasone; topical
1.7
7.8
188
1285
K30
ICD-10 Finland
Functional dyspepsia
2.4
7.7
56
251
M50.9
ICD-10 Finland
Cervical disc disorder, unspecified
45.7
7.7
9
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.5
7.7
50
213
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
7.7
63
298
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
7.7
97
542
UKC02
NOMESCO Finland
Cystoscopy
2.0
7.7
95
527
SPAT1216
SPAT
Assessment of functional ability
2.0
7.7
86
461
SPAT1097
SPAT
Recording of ECG
2.0
7.7
86
461
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.7
7.6
41
159
3015
Kela drug reimbursment
Alirocumab and evolocumab for the treatment of hypercholesterolaemia and dyslipidaemia
18.7
7.6
11
6
C10AA01
ATC
simvastatin; oral
1.7
7.6
246
1814
SPAT1254
SPAT
Administration of medicine
2.1
7.6
76
390
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
25.4
7.6
10
*
A08
ICPC
Swelling
2.8
7.6
39
148
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.2
7.5
70
349
C10AA07
ATC
rosuvastatin; oral
1.7
7.5
189
1303
ACC51
NOMESCO Finland
Release of median nerve
2.8
7.5
37
137
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.1
7.4
72
365
B01AF01
ATC
rivaroxaban; oral
2.0
7.4
81
430
R01AD58
ATC
fluticasone, combinations; nasal
1.9
7.3
107
628
NAG65
NOMESCO Finland
Anterior and posterior fusion of lumbar spine
+∞
7.3
7
*
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
+∞
7.3
7
*
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
+∞
7.3
7
*
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
7.3
7
*
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
+∞
7.3
7
*
A03FA02
ATC
cisapride; oral, rectal
2.6
7.3
43
175
J01CA04
ATC
amoxicillin; systemic
1.8
7.3
397
3346
L99
ICPC
Musculoskeletal disease other
5.9
7.3
19
33
K59.09
ICD-10 Finland
Constipation, unspecified
2.8
7.2
36
134
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
7.5
7.2
16
22
SPAT1260
SPAT
Consultation of another employee
2.0
7.2
90
500
WZA90
NOMESCO Finland
Other medical or dental certificate
1.8
7.2
116
701
N06AX26
ATC
vortioxetine; oral
2.9
7.2
34
123
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
7.2
139
888
294
Kela drug reimbursment
Alirocumab and evolocumab for the treatment of hypercholesterolaemia and dyslipidaemia
20.3
7.2
10
5
J45
ICD-10 Finland
Asthma
2.4
7.2
48
208
Z3231
NOMESCO Finland
Registered nurse
1.8
7.1
136
866
WX725
NOMESCO Finland
Noninvasive ventilation
2.9
7.1
34
124
J01FA09
ATC
clarithromycin; systemic
1.8
7.1
141
909
L04AA13
ATC
[U] leflunomide
6.5
7.0
17
27
M01AE52
ATC
naproxen and esomeprazole; oral
3.8
7.0
21
57
N05AH04
ATC
quetiapine; oral
2.0
7.0
78
417
G04BD12
ATC
mirabegron; oral
2.1
7.0
73
381
R10.0
ICD-10 Finland
Acute abdomen
4.1
6.9
19
48
R60.0
ICD-10 Finland
Localized oedema
2.1
6.9
68
346
P01AB01
ATC
metronidazole; oral, rectal
1.7
6.9
186
1299
NA3AA, ,
SPAT
3.5
6.9
23
67
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
6.9
141
914
H29
ICPC
Ear symptom/complaint other
2.1
6.9
70
361
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
6.9
128
808
R32
ICD-10 Finland
Unspecified urinary incontinence
4.2
6.9
18
44
J01FA10
ATC
azithromycin; systemic
1.6
6.9
254
1923
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
8.4
6.9
14
17
L04
ICPC
Chest symptom/complaint
2.7
6.9
37
144
SFA20
NOMESCO Finland
Two-surface restoration
1.6
6.8
283
2202
C07AB02
ATC
metoprolol; systemic
1.9
6.8
103
611
M53.8
ICD-10 Finland
Other specified dorsopathies
40.6
6.8
8
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
4.0
6.8
19
49
G04BD07
ATC
tolterodine; oral
3.1
6.8
28
94
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.5
6.7
43
182
A10BK03
ATC
empagliflozin; oral
2.0
6.7
73
386
UJD02
NOMESCO Finland
Gastroscopy
2.9
6.7
31
111
R52.1
ICD-10 Finland
Chronic intractable pain
22.8
6.7
9
*
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.0
6.7
29
100
SPAT1312
SPAT
General health counselling
1.7
6.7
147
972
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
6.6
6.7
16
25
C08CA13
ATC
lercanidipine; oral
1.9
6.7
87
491
D07XC01
ATC
betamethasone; topical
2.0
6.6
71
374
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
12.5
6.6
11
9
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
12.5
6.6
11
9
R5599
NOMESCO Finland
Other rehabilitation service
4.3
6.6
17
41
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.9
6.6
19
50
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
10.2
6.6
12
12
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
6.6
26
85
A10BJ02
ATC
liraglutide; parenteral
3.6
6.5
21
60
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.6
6.5
21
60
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
3.6
6.5
21
60
SPAT1255
SPAT
Intravenous administration of medicine
2.5
6.5
41
173
WZA00
NOMESCO Finland
Concise certificate
2.8
6.5
32
119
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.2
6.5
58
285
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.0
6.5
70
370
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
70.7
6.4
7
*
C10AX13
ATC
evolocumab; parenteral
14.5
6.4
10
7
TQW80
NOMESCO Finland
Local dermatologic skincare
3.8
6.4
19
51
H93.1
ICD-10 Finland
Tinnitus
2.5
6.4
42
180
J01EA01
ATC
trimethoprim; systemic
1.8
6.4
114
709
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
6.4
56
273
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.3
6.4
47
213
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.1
6.3
66
344
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.2
6.3
51
240
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
9.4
6.3
12
13
M77.9
ICD-10 Finland
Enthesopathy, unspecified
3.9
6.3
18
47
AEA24
NOMESCO Finland
Removal of spinal stimulation elecrode
+∞
6.3
6
*
G99.2*M47.9
ICD-10 Finland
Myelopathy in spondylosis
+∞
6.3
6
*
ABC66
NOMESCO Finland
Decompression of lumbal spinal channel
+∞
6.3
6
*
AB5CT
NOMESCO Finland
Blockage of nerv root with CT guidance
+∞
6.3
6
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
6.3
6
*
L85
ICPC
Acquired deformity of spine
+∞
6.3
6
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.6
6.3
36
145
NA3SA
NOMESCO Finland
Lumbar spine X-ray examination in standing position
27.0
6.2
8
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
6.2
102
618
SPAT1234
SPAT
Support of social functional capacity
2.8
6.2
30
110
L15
ICPC
Knee symptom/complaint
1.7
6.2
124
796
ZXD35
NOMESCO Finland
Usual procedure
3.6
6.2
20
57
SFA00
NOMESCO Finland
Small restoration
2.0
6.2
73
397
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
4.1
6.2
17
43
G43.9
ICD-10 Finland
Migraine, unspecified
3.5
6.2
21
62
P03
ICPC
Feeling depressed
2.6
6.2
36
146
R01AD01
ATC
beclometasone; nasal
2.0
6.2
73
398
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
6.2
75
413
L60.0
ICD-10 Finland
Ingrowing nail
2.9
6.2
29
105
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.8
6.1
18
48
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
6.1
242
1846
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
6.1
72
392
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
6.1
130
850
R51
ICD-10 Finland
Headache
3.3
6.1
23
73
M01AB08
ATC
etodolac; oral
2.6
6.1
36
147
A04
ICPC
Weakness/tiredness general
2.0
6.1
72
393
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.0
6.0
68
364
R01BA52
ATC
pseudoephedrine, combinations; oral
1.7
6.0
136
902
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
5.7
6.0
16
29
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
6.0
56
279
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.2
6.0
50
238
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
6.0
47
218
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
6.0
51
245
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.0
158
1091
N05BA01
ATC
diazepam; systemic, rectal
2.0
6.0
64
336
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
6.0
93
554
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
440
3193
3.48
24.85
6.1
4.0
13.18
13.13
mm/h
0.03
424
2934
153
698
2.69
21.57
1.4
1.3
18.72
38.98
iu/ml
2.67
44
214
137
637
2.56
18.23
1.5
1.3
6.91
15.58
u/ml
1.07
53
247
372
2683
2.36
17.31
5.8
5.1
7.07
6.82
mmol/l
1.22
359
2564
209
1195
2.25
17.27
2.6
2.9
350.99
359.44
umol/l
0.60
193
1051
305
2035
2.21
17.06
5.2
5.3
35.91
35.14
g/l
1.64
294
1907
353
2503
2.28
16.91
9.0
10.6
4.16
4.19
e9/l
0.10
320
2166
436
3422
2.71
16.12
9.5
8.6
80.01
81.12
u/l
0.21
423
3241
321
2236
2.14
15.44
20.4
14.7
1.30
1.27
inr
0.36
288
1866
225
1405
2.06
14.14
2.4
2.1
217.17
285.38
u/l
0.48
209
1324
319
2286
2.03
13.36
5.1
3.5
17.02
0.68
estimate
0.47
59
458
223
1412
2.02
13.27
3.7
2.5
52.80
70.21
u/l
2.59
217
1303
289
2010
1.99
13.07
3.3
2.8
—
—
estimate
—
0
0
333
2437
2.02
12.97
6.5
7.5
11.05
12.37
umol/l
1.48
317
2327
165
945
2.09
12.86
5.8
3.6
1.02
1.02
kg/l
0.15
120
628
316
2278
1.99
12.76
5.0
3.5
0.00
0.00
estimate
-0.00
70
502
313
2260
1.97
12.45
5.1
3.5
0.00
0.00
estimate
-0.00
68
501
260
1764
1.95
12.43
4.8
3.8
27.51
51.19
ng/l
2.83
195
1346
251
1686
1.95
12.33
4.5
4.2
6.26
7.82
mg/mmol
0.36
189
1080
95
447
2.38
11.91
2.1
2.3
175.28
124.69
ug/g
0.53
80
363
252
1714
1.91
11.75
5.2
3.5
9.09
0.02
estimate
0.49
55
407
487
4237
3.42
11.44
23.8
16.0
22.05
27.23
mg/l
3.65
443
3463
401
3204
2.11
11.42
5.0
4.0
15.27
14.97
pmol/l
1.51
382
2889
141
793
2.07
11.34
3.0
2.4
12.77
12.84
umol/l
0.04
133
732
247
1691
1.88
11.09
3.7
3.4
8.13
7.78
mmol/l
0.62
216
1419
310
2285
1.89
10.99
8.5
7.5
1.21
1.21
mmol/l
0.22
283
1955
222
1474
1.88
10.93
3.2
3.3
849.65
1386.75
ng/l
2.76
196
1278
270
1925
1.84
10.45
3.0
2.3
73.80
77.11
nmol/l
1.20
252
1706
267
1901
1.83
10.34
3.9
2.9
155.86
160.24
ug/l
0.11
254
1748
281
2039
1.82
10.16
2.5
2.1
94.80
96.15
pmol/l
0.18
168
1127
360
2825
1.90
10.05
6.5
4.2
22.33
1788.73
e6/l
—
6
49
145
860
1.95
9.87
1.4
1.2
2.90
1.17
u/ml
0.47
37
241
197
1294
1.84
9.78
5.4
3.6
0.00
0.01
estimate
0.78
64
459
128
738
1.97
9.41
3.0
2.4
2.37
2.25
g/l
1.78
118
682
222
1527
1.79
9.36
2.9
4.0
2.34
2.35
mmol/l
0.87
202
1388
276
2046
1.75
8.80
7.5
6.6
1.20
1.21
mmol/l
1.24
262
1890
119
684
1.96
8.77
2.9
2.5
20.04
23.06
%
1.90
113
635
457
3964
2.28
8.74
6.5
4.9
1.79
1.97
mu/l
3.42
431
3581
132
787
1.91
8.72
2.0
1.9
—
—
—
0
0
100
547
2.03
8.46
5.6
8.4
1.56
1.12
mmol/l
0.57
83
460
143
889
1.84
8.24
1.7
1.7
1.29
1.48
mg/l
0.20
109
712
105
595
1.96
8.01
1.8
1.8
—
—
—
0
0
476
4234
2.50
8.01
9.7
6.7
41.88
39.85
mmol/mol
4.80
456
3936
115
679
1.89
7.74
5.6
7.3
103.65
104.29
mmol/l
0.66
115
679
30
98
3.19
7.56
1.4
1.1
—
—
—
0
0
30
100
3.12
7.31
1.4
1.1
—
—
—
0
0
34
124
2.86
7.11
1.6
1.3
—
—
—
0
0
97
558
1.91
7.03
1.9
1.9
—
—
—
0
0
67
338
2.13
6.99
2.9
2.8
67.53
59.47
ml/min/173m2
0.83
30
131
207
1487
1.65
6.91
3.8
3.4
33.83
48.05
u/l
0.69
198
1400
494
4522
2.92
6.90
28.2
19.5
4.02
3.99
mmol/l
1.25
489
4416
493
4515
2.83
6.75
28.0
19.3
139.77
139.68
mmol/l
0.36
488
4419
169
1161
1.68
6.66
2.9
2.1
2.95
2.94
mg/l
0.02
152
981
73
390
2.01
6.53
3.0
2.3
5.35
7.18
ug/l
0.70
67
348
51
245
2.20
6.01
3.9
3.6
50.69
45.78
%
0.61
51
239
36
149
2.52
5.92
1.5
1.3
—
—
—
0
0
133
886
1.67
5.78
2.9
3.4
2.43
2.45
mmol/l
1.73
117
809
84
491
1.85
5.75
1.4
1.3
—
—
—
0
0
131
874
1.67
5.65
4.5
3.7
366.87
437.55
ng/l
0.18
105
719
185
1354
1.57
5.43
1.9
1.7
18.69
20.21
nmol/l
0.83
168
1129
148
1030
1.61
5.37
3.5
2.6
2.89
4.79
e6/l
4.15
135
940
112
730
1.68
5.25
1.9
1.7
1097.92
1133.51
nmol/l
0.19
98
554
78
460
1.82
5.18
3.9
3.5
2.79
1.92
mmol/l
1.09
70
382
59
325
1.92
4.84
4.0
3.7
95.20
89.03
ng/l
0.21
52
274
198
1504
1.51
4.78
4.4
3.2
58.67
122.67
e6/l
0.51
168
1154
31
133
2.42
4.76
1.5
1.5
0.02
0.04
iu/ml
—
6
14
491
4585
2.31
4.69
16.4
12.3
27.55
26.92
u/l
0.37
482
4444
342
2914
1.51
4.63
3.9
3.2
49.99
57.89
u/l
1.46
327
2722
58
324
1.89
4.57
1.9
1.6
—
—
—
0
0
26
106
2.53
4.45
1.1
1.2
2.54
3.02
u/ml
—
5
16
466
4286
1.85
4.44
7.1
5.3
6.32
6.05
mmol/l
4.16
439
3881
117
806
1.58
4.34
3.5
3.7
0.82
0.82
mmol/l
0.26
112
758
275
2261
1.46
4.33
2.6
2.5
—
—
—
0
0
8
10
8.10
4.07
1.3
1.7
255.25
203.60
u/l
—
8
10
133
956
1.53
4.06
2.0
1.8
92562376.97
27648999.32
pmol/l
0.46
121
774
148
1091
1.50
4.01
2.8
2.5
—
—
—
0
0
79
504
1.67
3.98
10.7
6.2
—
—
—
0
0
166
1255
1.47
3.96
3.7
3.1
4.81
0.07
estimate
0.48
52
369
81
526
1.64
3.81
3.1
2.9
7.43
9.21
umol/l
0.55
72
471
45
250
1.88
3.63
4.2
2.4
0.73
0.64
%
0.93
45
250
451
4160
1.64
3.60
5.7
4.4
1.47
1.30
mmol/l
5.34
425
3785
475
4444
1.81
3.57
7.7
6.0
2.53
2.65
mmol/l
2.11
455
4080
58
357
1.70
3.34
1.5
1.4
—
—
—
0
0
47
274
1.79
3.27
3.3
4.0
2.88
2.35
mmol/l
0.43
34
214
64
407
1.65
3.27
4.3
2.8
4.67
4.54
kpa
0.17
64
393
12
34
3.59
3.21
2.4
2.8
686.25
1228.38
mg
0.61
12
34
26
125
2.14
3.14
1.6
1.5
—
—
—
0
0
30
153
2.02
3.11
1.4
2.0
7.24
8.88
iu/ml
—
7
38
164
1297
1.39
2.92
4.3
3.1
0.28
0.51
e6/l
1.57
135
948
11
32
3.49
2.91
1.1
1.3
—
—
—
0
0
25
123
2.08
2.86
2.0
2.5
92.31
96.39
ug/min
0.02
16
76
26
130
2.05
2.86
1.5
1.5
9.85
10.40
u/ml
—
6
23
465
4370
1.62
2.85
6.9
5.3
4.41
4.55
mmol/l
2.32
443
4033
12
40
3.05
2.71
1.6
1.7
—
—
—
0
0
462
4347
1.57
2.67
6.6
5.2
1.35
1.43
mmol/l
4.33
439
3980
20
93
2.20
2.64
1.4
1.6
—
—
—
0
0
21
101
2.12
2.56
1.1
1.2
—
—
—
0
0
38
225
1.74
2.55
1.6
1.3
—
—
—
0
0
24
122
2.01
2.54
1.5
1.4
283.44
264.07
ug/g
0.21
19
77
63
428
1.54
2.47
6.7
8.2
1.11
1.37
mmol/l
2.43
63
423
12
45
2.71
2.46
3.3
2.6
14.50
25.33
mg/l
—
5
15
18
85
2.16
2.31
1.2
1.4
—
—
—
0
0
10
35
2.89
2.22
1.7
1.7
—
—
—
0
0
453
4278
1.46
2.21
20.9
16.1
77.28
78.03
ml/min/173m2
0.35
438
3975
15
67
2.28
2.19
1.3
1.4
—
—
—
0
0
24
130
1.89
2.16
1.5
1.4
—
—
—
0
0
224
1924
1.29
2.14
2.2
1.9
1.51
1.35
mmol/l
2.26
194
1564
8
25
3.23
2.10
1.4
1.6
—
—
—
0
0
8
25
3.23
2.10
1.4
1.6
—
—
—
0
0
10
37
2.74
2.08
1.7
1.7
—
—
—
0
0
28
162
1.77
2.06
1.8
1.8
—
—
—
0
0
20
104
1.96
2.03
1.6
1.6
—
—
—
0
0
243
2122
1.27
1.99
6.4
5.4
2.13
2.53
ug/l
0.81
224
1904
20
105
1.94
1.98
1.6
1.6
—
—
—
0
0
7
21
3.36
1.97
1.1
1.4
—
—
—
0
0
56
391
1.48
1.96
3.6
3.0
66.87
66.66
g/l
0.07
50
366
102
802
1.34
1.83
3.5
2.8
0.67
1.22
e6/l
2.30
66
429
198
1704
1.26
1.79
5.4
4.3
19.83
21.65
%
1.37
102
847
6
18
3.36
1.75
1.2
1.0
—
—
—
0
0
9
36
2.53
1.74
1.2
1.3
—
—
—
0
0
11
48
2.32
1.71
1.1
1.2
8.31
7.83
mmol/l
0.22
11
40
12
55
2.21
1.68
1.2
1.2
259.42
353.96
pmol/l
0.51
12
50
12
55
2.21
1.68
2.8
2.3
0.13
0.79
mmol/l
0.24
12
55
23
135
1.74
1.65
2.0
1.6
—
—
—
0
0
8
33
2.45
1.54
1.0
1.1
—
—
—
0
0
8
33
2.45
1.54
1.0
1.1
—
—
—
0
0
65
490
1.37
1.54
1.7
1.7
1.50
1.60
%
0.64
59
414
6
21
2.88
1.51
1.5
1.7
—
—
—
0
0
6
21
2.88
1.51
1.5
1.7
—
—
—
0
0
61
457
1.38
1.50
3.2
2.2
13.47
13.20
nmol/l
0.08
52
420
12
58
2.09
1.50
1.8
2.5
1.22
1.19
mmol/l
0.77
12
58
32
212
1.54
1.47
1.1
1.2
187.44
125.86
u/ml
—
10
82
20
117
1.74
1.47
1.6
1.7
—
—
—
0
0
29
188
1.57
1.46
1.5
2.3
44.89
37.77
u/l
1.16
29
165
11
52
2.14
1.45
1.6
1.7
—
—
—
0
0
11
52
2.14
1.45
1.6
1.7
—
—
—
0
0
12
59
2.06
1.44
1.8
2.5
3.91
4.00
mmol/l
0.30
12
59
12
59
2.06
1.44
1.8
2.5
106.42
105.05
mmol/l
0.43
12
59
20
118
1.72
1.43
1.2
2.5
14.34
13.22
mg/l
0.25
20
110
93
749
1.29
1.42
3.6
2.9
1.59
1.76
e6/l
0.14
59
378
10
46
2.20
1.40
1.6
1.8
—
—
—
0
0
27
174
1.58
1.40
2.1
2.0
—
—
—
0
0
11
53
2.10
1.39
1.6
1.7
—
—
—
0
0
29
192
1.54
1.35
1.5
1.6
—
—
—
0
0
28
413
0.66
1.34
2.6
2.2
3.68
3.52
ratio
0.31
23
338
9
42
2.16
1.34
1.1
1.1
—
—
—
0
0
11
54
2.06
1.33
1.6
1.6
—
—
—
0
0
11
55
2.02
1.28
1.6
1.6
—
—
—
0
0
11
55
2.02
1.28
1.6
1.6
—
—
—
0
0
14
77
1.84
1.26
1.5
1.8
—
—
—
0
0
17
100
1.72
1.25
1.4
1.8
—
—
—
0
0
8
37
2.18
1.22
1.0
1.1
—
—
—
0
0
8
38
2.12
1.19
1.0
1.1
—
—
—
0
0
54
416
1.33
1.15
2.4
2.3
39.24
47.53
u/l
0.24
46
355
7
32
2.20
1.08
1.3
1.3
—
74.29
—
0
7
7
32
2.20
1.08
1.1
1.2
—
—
—
0
0
27
187
1.47
1.06
2.3
3.0
—
—
—
0
0
5
23
2.18
0.98
1.2
1.1
—
—
—
0
0
30
216
1.41
0.98
1.5
1.7
—
—
—
0
0
6
27
2.24
0.93
1.2
1.0
—
—
—
0
0
6
27
2.24
0.93
1.2
1.0
—
—
—
0
0
6
27
2.24
0.93
1.0
8.4
—
38.13
—
0
8
9
52
1.74
0.92
1.1
1.2
2.12
1.51
nmol/l
—
9
46
19
126
1.53
0.92
1.5
1.4
—
—
—
0
0
6
28
2.16
0.91
2.2
3.5
2.25
1.27
%
—
6
28
6
28
2.16
0.91
1.2
1.4
16.95
24.47
u/l
—
6
23
62
505
1.26
0.90
3.9
3.0
—
—
—
0
0
6
29
2.08
0.89
1.0
1.1
—
—
—
0
0
6
29
2.08
0.89
2.5
1.4
126.57
63.29
ng/l
—
6
29
12
71
1.71
0.89
1.5
1.8
—
—
—
0
0
48
383
1.28
0.83
3.2
3.6
1.22
1.23
mmol/l
0.51
43
323
12
74
1.64
0.79
1.8
1.3
—
—
—
0
0
12
74
1.64
0.79
1.8
1.3
—
—
—
0
0
9
58
1.56
0.70
1.7
1.7
—
—
—
0
0
22
295
0.73
0.69
2.2
1.9
3.26
3.44
mmol/l
0.43
15
222
24
180
1.35
0.66
1.0
1.1
—
—
—
0
0
20
146
1.38
0.64
1.5
1.8
—
—
—
0
0
24
181
1.34
0.64
1.4
1.5
0.13
0.36
mg/l
3.96
11
94
5
29
1.73
0.64
1.8
2.1
39.26
41.28
g/l
—
5
29
12
79
1.53
0.63
3.5
3.1
7.08
10.17
pmol/l
0.79
12
79
8
50
1.61
0.61
1.3
1.9
—
—
—
0
0
8
53
1.52
0.58
5.1
3.8
—
—
—
0
0
15
107
1.41
0.56
1.7
1.6
—
—
—
0
0
13
90
1.46
0.56
1.5
1.2
—
—
—
0
0
10
65
1.55
0.56
1.2
2.1
—
—
—
0
0
19
142
1.35
0.55
1.4
1.7
—
—
—
0
0
37
306
1.23
0.52
1.8
1.6
—
—
—
0
0
6
41
1.47
0.50
1.0
1.1
323.33
265.25
mg/l
—
6
36
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
163
1.30
0.49
2.1
2.6
0.29
0.40
iu/ml
0.89
12
86
11
78
1.42
0.43
1.3
2.0
—
—
—
0
0
20
158
1.28
0.42
2.9
3.2
3.69
2.72
ratio
0.22
13
86
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
7
102
0.68
0.40
1.3
1.5
—
—
—
0
0
10
71
1.42
0.39
7.1
6.0
12.62
10.83
mg/l
—
10
66
9
66
1.37
0.38
1.2
1.1
121.78
114.69
%
—
9
61
9
68
1.33
0.37
1.0
1.1
1.54
1.54
g/l
—
9
63
16
126
1.28
0.35
3.1
3.6
0.00
1.87
index
—
6
75
6
44
1.37
0.34
1.3
1.1
—
—
—
0
0
12
92
1.31
0.32
1.1
1.4
113.17
931.60
e6/l
0.50
12
72
12
92
1.31
0.32
1.0
1.2
2.33
47.29
e6/l
0.68
12
69
61
557
1.11
0.28
4.0
5.0
5.21
34.61
ug/l
1.28
48
465
8
65
1.23
0.27
1.3
1.1
—
—
—
0
0
10
78
1.29
0.24
1.1
1.1
—
—
—
0
0
136
1301
1.06
0.22
3.5
3.2
0.60
0.76
ug/l
3.24
93
864
0
10
0.00
0.21
0.0
1.7
—
49.81
—
0
10
0
10
0.00
0.21
0.0
1.4
—
3.05
—
0
10
15
126
1.20
0.21
1.5
1.7
—
—
—
0
0
13
108
1.21
0.20
1.3
1.3
—
—
—
0
0
17
146
1.17
0.19
2.8
1.7
36.24
39.33
nmol/l
0.38
17
141
11
91
1.21
0.17
1.1
1.2
4.66
3.83
mmol/l
0.86
11
86
10
119
0.84
0.15
4.1
2.9
39.70
45.46
umol/l
—
10
110
26
237
1.10
0.14
1.5
2.0
1.40
1.57
g/l
0.33
21
210
9
110
0.81
0.13
1.0
1.3
—
—
—
0
0
58
609
0.95
0.12
5.4
5.0
29.78
31.56
%
0.68
45
387
14
124
1.13
0.11
1.5
1.5
—
—
—
0
0
16
144
1.11
0.10
2.3
2.4
3.42
3.83
g/l
0.55
16
136
10
114
0.87
0.09
1.0
1.2
1.58
1.52
g/l
—
10
114
6
54
1.11
0.09
2.5
3.1
—
—
—
0
0
6
54
1.11
0.09
1.3
1.8
—
—
—
0
0
6
55
1.09
0.09
1.3
1.8
—
—
—
0
0
7
64
1.09
0.08
1.0
1.2
—
—
—
0
0
42
402
1.05
0.07
1.5
1.5
—
—
—
0
0
14
150
0.93
0.04
2.1
2.0
98.00
91.46
%
0.52
14
145
11
112
0.98
0.00
3.7
7.0
—
307.54
—
0
13
11
109
1.01
0.00
1.1
1.3
497.00
512.50
mg/l
0.07
11
104
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
—
—
0
0
5
51
0.98
-0.00
1.4
1.5
—
—
—
0
0
5
51
0.98
-0.00
1.4
1.5
—
—
—
0
0
5
51
0.98
-0.00
1.4
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
6.0
—
35.13
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint M13_FORESTIER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FORESTIER | 1.208 [1.03, 1.42] | 0.021 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 210 out of 1048 females with M13_FORESTIER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FORESTIER | 1.194 [1.04, 1.37] | 0.012 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 338 out of 1527 males with M13_FORESTIER died.
Mortality risk
Mortality risk for people of age
years, who have M13_FORESTIER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.213% |
| 5 | 0.511% | 1.204% |
| 10 | 1.405% | 3.308% |
| 15 | 2.672% | 6.12% |
| 20 | 4.768% | 10.485% |
Relationships between endpoints
↥Index endpoint: M13_FORESTIER – Ankylosing hyperostosis [Forestier]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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