Contracture of joint

M13_CONTRACTUREJOINT

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M24.5
  • Hospital discharge: ICD-9 7184
  • Hospital discharge: ICD-8 72900
  • Cause of death: ICD-10 M24.5
  • Cause of death: ICD-9 7184
  • Cause of death: ICD-8 72900

2 out of 7 registries used, show all original rules.

557

4. Check minimum number of events

None

557

5. Include endpoints

None

557

6. Filter based on genotype QC (FinnGen only)

490

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M24
Name in latin
Contractura articulationis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4443 2087 2306
Only index persons 3699 1819 1880
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.07 0.07 0.07
Median age at first event (years)
Whole population 50.49 51.25 49.64
Only index persons 48.48 50.18 46.83

-FinnGen-

Key figures

All Female Male
Number of individuals 490 260 230
Unadjusted period prevalence (%) 0.10 0.09 0.11
Median age at first event (years) 50.93 48.66 53.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
513
Matched controls
5130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M24.5
ICD-10 Finland
Contracture of joint
+∞
307.7
355
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
20.4
171.8
145
97
M19.0
ICD-10 Finland
Primary arthrosis of other joints
27.8
130.3
92
40
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
19.2
124.1
104
67
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
42.9
105.1
64
17
72900
ICD-8 Finland
Other diseases of joint, Contractura articuli
+∞
102.6
95
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
14.9
102.2
98
80
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
58.2
100.5
57
11
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
89.2
83
*
M25.5
ICD-10 Finland
Pain in joint
4.8
62.2
199
599
M16.1
ICD-10 Finland
Other primary coxarthrosis
16.1
53.4
47
32
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
48.7
46
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
9.6
48.3
60
70
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
14.5
47.4
44
33
NGT60
NOMESCO Finland
Forcible manipulation of knee joint
+∞
46.6
44
*
1220
FHL
Arthroscopy
15.4
44.7
40
28
ZXA05
NOMESCO Finland
Left side
4.0
44.6
174
588
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
9.9
43.2
52
58
ZXA00
NOMESCO Finland
Right side
3.8
42.6
182
651
N02AX02
ATC
tramadol; systemic, rectal
3.3
39.2
268
1275
WX320
NOMESCO Finland
Spinalanesthesy
4.0
38.8
140
443
X59
ICD-10 Finland
Exposure to unspecified factor
3.8
36.8
142
469
R4120
NOMESCO Finland
Occupational therapy
6.3
35.8
65
116
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
12.9
35.4
35
29
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
13.4
35.2
34
27
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
5.6
34.7
72
146
Z3226
NOMESCO Finland
Physiotherapist
3.8
34.3
129
417
B01AB05
ATC
enoxaparin; parenteral
3.3
33.7
181
733
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.1
33.7
249
1211
M72.0
ICD-10 Finland
Palmar fascial fibromatosis [Dupuytren]
7.7
33.6
49
69
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.5
32.4
68
139
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
56.8
31.7
37
7
P01BA02
ATC
hydroxychloroquine; oral
10.4
31.6
36
37
L15
ICPC
Knee symptom/complaint
3.5
31.5
140
503
R4110
NOMESCO Finland
Physiotherapy
3.1
31.4
185
786
L90
ICPC
Osteoarthrosis of knee
9.3
31.4
39
45
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
6.9
31.4
51
81
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
30.5
29
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.2
30.2
55
98
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
5.3
29.9
65
137
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
6.1
29.4
54
97
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
5.6
29.3
59
116
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
29.0
233
1163
WX702
NOMESCO Finland
Supraglottic ventilation device
6.0
28.8
54
99
N03AX16
ATC
[U] pregabalin
3.2
28.5
141
537
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.1
28.3
152
608
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
6.4
27.8
48
81
M01AX05
ATC
glucosamine; oral
3.9
27.8
92
270
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
+∞
26.3
25
*
X58
ICD-10 Finland
Exposure to other specified factors
3.5
26.2
104
344
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
25.9
214
1070
M20.1
ICD-10 Finland
Hallux valgus (acquired)
10.5
24.9
28
28
M13.9
ICD-10 Finland
Arthritis, unspecified
9.1
24.8
31
36
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.8
24.7
85
255
M79.6
ICD-10 Finland
Pain in limb
2.6
24.4
233
1243
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
59.1
24.3
28
5
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
39.7
24.2
30
8
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
23.3
227
1217
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
68.3
23.0
26
*
NDE60
NOMESCO Finland
Incision and release of adhesions in joint of finger or metacarpal
125.6
22.8
24
*
WX111
NOMESCO Finland
Local infiltration anesthesia
125.6
22.8
24
*
NDM10
NOMESCO Finland
Palmar fasciotomy of hand
8.0
22.3
31
41
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
22.2
191
961
WX203
NOMESCO Finland
Infraclavicular plexus blockade
8.9
22.1
28
33
ZXE00
NOMESCO Finland
One hour or less
2.5
21.8
218
1174
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
4.6
21.7
54
127
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.6
21.2
53
125
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
39.0
21.0
26
7
S18
ICPC
Laceration/cut
2.4
20.3
252
1484
WX212
NOMESCO Finland
Femoral plexus blockade
8.3
20.2
27
34
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
196.9
18.7
19
*
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
6.6
17.7
29
46
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
16.4
17.7
28
18
S83.2
ICD-10 Finland
Tear of meniscus, current
4.8
17.3
40
88
WX200
NOMESCO Finland
Interscalenous plexus blockade
18.2
17.1
26
15
ZXD20
NOMESCO Finland
Day surgery
3.1
17.0
77
273
NCF25
NOMESCO Finland
Operation for osteochondritis of elbow joint, arthroscopic
175.5
16.6
17
*
9253
FHL
Manipulation under anesthesia or regression and plastering
41.6
16.4
20
5
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
4.0
16.4
49
132
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
13.4
16.3
28
22
M01AH01
ATC
celecoxib; oral
2.9
16.3
86
333
M01AH05
ATC
etoricoxib; oral
2.2
16.2
302
2035
N02BE01
ATC
paracetamol; systemic, rectal
3.2
16.1
459
3717
L28
ICPC
Limited function/disability (L)
2.7
16.0
100
422
N03AX12
ATC
[U] gabapentin; oral
2.9
16.0
86
336
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
15.8
204
1190
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
5.9
15.7
29
52
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
15.5
119
555
N06AX21
ATC
duloxetine; oral
3.1
15.5
71
253
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
39.4
15.5
19
5
S62.6
ICD-10 Finland
Fracture of other finger
4.6
15.2
37
85
NBE15
NOMESCO Finland
Incision or suture of capsule of joint of shoulder, arthroscopic
46.5
15.2
18
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
14.9
146
758
7184D
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, KÄSI]
+∞
14.7
14
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
14.4
68
246
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.6
14.4
97
424
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.9
14.4
77
299
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.4
14.3
53
166
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.4
14.2
37
90
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
54.9
13.9
16
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.2
13.7
38
97
7184F
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, POLVI]
+∞
13.6
13
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
13.6
13
*
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
13.6
13
*
L04AX03
ATC
methotrexate; systemic
4.5
13.6
34
80
WX002
NOMESCO Finland
Sedation and analgesia
2.5
13.6
97
436
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
13.5
192
1148
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
10.9
13.4
25
24
S70.0
ICD-10 Finland
Contusion of hip
5.5
13.4
26
49
M54.5
ICD-10 Finland
Low back pain
2.1
13.3
182
1071
Z50.1
ICD-10 Finland
Other physical therapy
4.1
13.2
37
95
WX204
NOMESCO Finland
Axillary plexus blockaced
5.2
13.0
27
54
M19.8
ICD-10 Finland
Other specified arthrosis
5.8
13.0
24
43
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
14.5
12.9
21
15
S83.4
ICD-10 Finland
Sprain and strain involving (fibular)(tibial) collateral ligament of knee
6.0
12.8
23
40
G56.2
ICD-10 Finland
Lesion of ulnar nerve
5.3
12.8
26
51
L88
ICPC
Rheumatoid/seropositive arthritis
15.9
12.7
20
13
M17.5
ICD-10 Finland
Other secondary gonarthrosis
71.7
12.6
14
*
L12
ICPC
Hand/finger symptom/complaint
2.5
12.6
92
417
7184E
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, LONKKANIVEL]
+∞
12.5
12
*
J01DA01
ATC
[U] cefalexin
2.0
12.5
316
2290
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.0
12.4
36
95
A02BC02
ATC
pantoprazole; systemic
2.0
12.3
335
2487
M23.8
ICD-10 Finland
Other internal derangements of knee
12.8
12.2
21
17
L08
ICPC
Shoulder symptom/complaint
2.3
12.1
114
576
M09AX01
ATC
hyaluronic acid; parenteral
9.6
12.1
24
26
M22.4
ICD-10 Finland
Chondromalacia patellae
27.4
12.1
16
6
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
5.0
12.0
26
54
A07EC01
ATC
sulfasalazine; oral, rectal
4.3
12.0
31
75
N02BF02
ATC
pregabalin; oral
3.6
11.9
40
117
TQW40
NOMESCO Finland
Remowal of suture of skin
3.4
11.8
43
133
NF1AA
NOMESCO Finland
Hip X-ray examination
3.9
11.8
35
94
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
11.7
182
1111
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
11.6
78
339
Z3231
NOMESCO Finland
Registered nurse
2.1
11.6
146
826
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
4.2
11.6
31
77
M01AB05
ATC
diclofenac; systemic, rectal
1.9
11.5
322
2386
E66.01
ICD-10 Finland
Obesity due to excess calories
3.0
11.5
53
189
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
11.5
11
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
122.7
11.5
12
*
L01BA01
ATC
methotrexate; systemic
20.6
11.2
16
8
L84
ICD-10 Finland
Corns and callosities
5.4
11.2
22
42
WX110
NOMESCO Finland
Infiltration anesthesia
2.0
11.1
354
2724
J01DB01
ATC
cefalexin; oral
2.1
11.1
404
3260
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
5.6
11.0
21
39
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
8.5
10.9
23
28
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.8
10.7
33
91
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
61.3
10.7
12
*
B01AF01
ATC
rivaroxaban; oral
2.9
10.7
54
203
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.0
10.6
50
181
L17
ICPC
Foot/toe symptom/complaint
2.0
10.5
143
829
M01AH03
ATC
valdecoxib; oral
3.5
10.5
36
107
M24.4
ICD-10 Finland
Recurrent dislocation and subluxation of joint
+∞
10.4
10
*
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
10.4
10
*
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
12.4
10.4
18
15
NB2AT
NOMESCO Finland
Intra artrial injection of shoulder with ultrasound guidance
33.3
10.4
13
*
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
33.3
10.4
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
10.2
114
614
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
5.2
10.1
21
42
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
40.9
10.0
12
*
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
3.8
10.0
31
86
M75.5
ICD-10 Finland
Bursitis of shoulder
5.4
9.7
19
36
NG1DA
NOMESCO Finland
X-ray of knees
56.1
9.7
11
*
1225
FHL
Arthroscopy and other therapeutic procedure
56.1
9.7
11
*
M24.2
ICD-10 Finland
Disorder of ligament
56.1
9.7
11
*
M01AC06
ATC
meloxicam; systemic, rectal
1.9
9.7
161
996
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.2
9.6
20
40
M01AH02
ATC
rofecoxib; oral
2.6
9.5
58
240
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
3.5
9.5
33
99
R5110, ,
SPAT
2.9
9.4
47
175
NDL54
NOMESCO Finland
Tenolysis of hand
30.6
9.4
12
*
WX402
NOMESCO Finland
General anaesthesia
2.0
9.4
122
692
ACC51
NOMESCO Finland
Release of median nerve
3.1
9.4
40
136
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
9.4
9
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
9.4
9
*
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
+∞
9.4
9
*
R52.9
ICD-10 Finland
Pain, unspecified
2.6
9.4
55
223
H02AB06
ATC
prednisolone; systemic
1.8
9.4
221
1519
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
4.8
9.4
21
45
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
9.4
76
359
E883A
ICD-9 Finland
Fall into hole or other opening in surface
3.5
9.3
33
100
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.4
9.2
33
101
J01FF01
ATC
clindamycin; systemic
1.9
9.2
133
784
ND1AA
NOMESCO Finland
Wrist X-ray examination
2.9
9.2
43
155
N02BF01
ATC
gabapentin; oral
2.7
9.1
52
208
ZXD05
NOMESCO Finland
Urgent procedure
1.9
9.1
157
980
Z09.4
ICD-10 Finland
Follow-up examination after treatment of fracture
3.2
9.0
37
123
M15
ICD-10 Finland
Polyarthrosis
4.5
8.9
22
51
M48.0
ICD-10 Finland
Spinal stenosis
2.6
8.9
56
235
NBF25
NOMESCO Finland
Operation for humeroscapular osteochondritis, arthroscopic
8.2
8.9
19
24
S80.0
ICD-10 Finland
Contusion of knee
2.9
8.7
43
159
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
6.8
8.7
21
32
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.2
8.6
34
111
M02AA07
ATC
piroxicam; topical
1.8
8.5
164
1054
NGE35
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic
7.5
8.5
19
26
T92.1
ICD-10 Finland
Sequelae of fracture of arm
28.0
8.5
11
*
B01AX06
ATC
[U] rivaroxaban
91.5
8.4
9
*
NDG76
NOMESCO Finland
Fusion of DIP joint
91.5
8.4
9
*
K02.1
ICD-10 Finland
Caries of dentine
1.7
8.4
280
2105
A04
ICPC
Weakness/tiredness general
2.1
8.4
82
418
M25.6
ICD-10 Finland
Stiffness of joint, not elsewhere classified
+∞
8.4
8
*
M22.0
ICD-10 Finland
Recurrent dislocation of patella
+∞
8.4
8
*
7184A
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, OLKANIVEL]
+∞
8.4
8
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
8.4
8
*
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
8.4
8
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
8.4
8
*
7184B
ICD-9 Finland
Other derangement of joint, Contracture of joint[CONTRACTURA, KYYNÄRNIVEL]
+∞
8.4
8
*
R06AE07
ATC
cetirizine; oral
1.7
8.3
202
1389
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.7
8.3
218
1532
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.4
8.2
29
88
A01
ICPC
Pain general/multiple sites
2.6
8.2
50
207
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
8.2
117
684
M01AX17
ATC
nimesulide; oral
2.0
8.1
105
593
L40.5
ICD-10 Finland
Arthropathic psoriasis
33.9
8.1
10
*
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
3.5
8.0
28
84
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
8.0
222
1581
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.7
7.9
25
70
S83.0
ICD-10 Finland
Dislocation of patella
11.0
7.8
14
13
A10AB01
ATC
insulin (human); parenteral
3.5
7.8
27
81
SPAT1229
SPAT
Assessment of need for aid
3.0
7.7
35
124
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.0
7.7
35
124
S89.9
ICD-10 Finland
Unspecified injury of lower leg
4.1
7.7
21
53
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.7
7.6
42
165
M65.3
ICD-10 Finland
Trigger finger
3.3
7.6
28
87
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
3.5
7.6
26
77
S72.4
ICD-10 Finland
Fracture of lower end of femur
25.4
7.6
10
*
M01AE02
ATC
naproxen; oral, rectal
1.7
7.6
262
1968
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
7.5
86
464
B01AB10
ATC
tinzaparin; parenteral
2.4
7.5
51
222
J01MA02
ATC
ciprofloxacin; systemic
1.7
7.5
185
1269
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
7.5
47
197
W19
ICD-10 Finland
Unspecified fall
2.4
7.5
54
242
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
7.4
55
249
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
7.4
152
989
M25.4
ICD-10 Finland
Effusion of joint
13.6
7.4
12
9
KMAK, ,
NOMESCO Finland
1.7
7.3
235
1726
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
7.3
131
819
NGH99
NOMESCO Finland
Other operation on knee joint, unspecified
+∞
7.3
7
*
M01AE01
ATC
ibuprofen; systemic, rectal
2.0
7.3
438
3817
J01AA02
ATC
doxycycline; systemic
1.8
7.3
378
3148
H3603, E103,
ICD-10 Finland
16.0
7.3
11
7
N02AA05
ATC
oxycodone; systemic
2.0
7.2
85
463
A29
ICPC
General symptom/complaint other
2.1
7.2
71
362
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.7
7.2
256
1928
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
3.0
7.2
32
112
M23.3
ICD-10 Finland
Other meniscus derangements
30.5
7.2
9
*
NG1EA
NOMESCO Finland
Knee X-ray examination with wrench
30.5
7.2
9
*
NDL99
NOMESCO Finland
Other operation on muscle or tendon of wrist or hand
30.5
7.2
9
*
1221
FHL
Arthroscopy and meniscus surgery
20.4
7.2
10
5
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
7.2
80
428
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.2
7.1
19
47
N06AA09
ATC
amitriptyline; systemic
2.5
7.1
47
202
M03BX02
ATC
tizanidine; oral
1.7
7.1
286
2221
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
7.1
7.0
16
23
Z2221
NOMESCO Finland
Medical doctor
1.8
7.0
132
837
E0000UV, ,
ATC
1.7
6.9
194
1371
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
14.0
6.9
11
8
S20.2
ICD-10 Finland
Contusion of thorax
3.0
6.9
31
109
TQW40, ,
SPAT
2.3
6.9
51
231
M02AA10
ATC
ketoprofen; topical
2.1
6.9
73
383
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.2
6.9
59
285
NBL05
NOMESCO Finland
Arthroscopic suture or reinsertation of rotator cuff of shoulder
8.4
6.9
14
17
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.8
135
868
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
4.4
6.8
17
40
L29
ICPC
Musculoskeletal sympt/complt other
2.5
6.8
41
169
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
6.8
62
307
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
40.6
6.8
8
*
M25.2
ICD-10 Finland
Flail joint
40.6
6.8
8
*
L04AA13
ATC
[U] leflunomide
40.6
6.8
8
*
L11
ICPC
Wrist symptom/complaint
2.5
6.7
44
189
NDJ64
NOMESCO Finland
Internal fixation of fracture of wrist or hand wire, rod, cerclage or pin
6.6
6.7
16
25
R52.2
ICD-10 Finland
Other chronic pain
3.7
6.7
21
59
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
6.6
81
448
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.7
6.5
34
130
L13
ICPC
Hip symptom/complaint
2.0
6.5
71
376
M01AB55
ATC
diclofenac, combinations; oral
3.0
6.5
29
102
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
6.5
66
341
NCE15
NOMESCO Finland
Incision or delibaration of capsule of elbow joint, open
70.7
6.4
7
*
1222
FHL
Arthroscopy and synovial surgery
70.7
6.4
7
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
6.4
49
225
M20.2
ICD-10 Finland
Hallux rigidus
14.5
6.4
10
7
M03BC01
ATC
orphenadrine (citrate); systemic
1.8
6.4
98
582
W17
ICD-10 Finland
Other fall from one level to another
3.2
6.4
25
81
M77.1
ICD-10 Finland
Lateral epicondylitis
2.5
6.4
41
174
B01AB04
ATC
dalteparin; parenteral
3.4
6.3
22
66
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
11.2
6.3
11
10
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.1
6.3
26
87
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
9.4
6.3
12
13
S06.0
ICD-10 Finland
Concussion
2.2
6.3
56
274
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
6.3
87
500
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.4
6.3
45
201
Z02.7
ICD-10 Finland
Issue of medical certificate
2.5
6.3
39
163
W22
ICD-10 Finland
Striking against or struck by other object(s)
2.7
6.3
33
127
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
+∞
6.3
6
*
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
+∞
6.3
6
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
+∞
6.3
6
*
73799
ICD-8 Finland
Hallux valgus and varus
+∞
6.3
6
*
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
+∞
6.3
6
*
M25.0
ICD-10 Finland
Haemarthrosis
+∞
6.3
6
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
6.3
6
*
S52.1
ICD-10 Finland
Fracture of upper end of radius
7.2
6.3
14
20
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
2.5
6.2
40
170
ZXA10
NOMESCO Finland
Bilateral
1.9
6.2
82
464
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.6
6.2
20
57
W31
ICD-10 Finland
Contact with other and unspecified machinery
4.1
6.2
17
43
NG1AA, ,
SPAT
2.5
6.2
39
164
M65.8
ICD-10 Finland
Other synovitis and tenosynovitis
6.4
6.2
15
24
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.7
6.1
123
791
L03
ICPC
Low back symptom/complaint
1.7
6.1
126
817
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
3.3
6.1
23
73
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
8.7
6.1
12
14
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
6.1
220
1644
Y96.9
ICD-10 Finland
Unspecified type of accident
5.3
6.1
17
33
R05
ICPC
Cough
1.8
6.0
110
689

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
108
491
2.52
14.81
1.4
1.1
3.79
1.64
u/ml
0.50
32
202
115
550
2.41
14.08
1.4
1.2
350.05
17.37
iu/ml
0.53
33
148
157
861
2.19
13.87
2.6
2.5
346.11
344.76
umol/l
0.06
140
763
259
1741
1.98
12.94
4.2
5.2
35.60
35.75
g/l
0.16
250
1644
192
1178
2.01
12.32
5.2
6.3
—
—
—
0
0
255
1725
1.95
12.31
3.0
2.7
—
—
estimate
—
0
0
100
489
2.30
11.47
2.4
1.9
—
—
—
0
0
17
10
17.54
11.26
1.4
1.1
—
—
—
0
0
90
436
2.29
10.50
1.5
1.2
621.54
440.48
titre
0.19
13
84
176
1104
1.90
10.21
3.8
3.0
0.35
0.51
e6/l
0.75
127
792
21
25
8.71
10.14
1.5
1.1
2068.82
9982.45
e6/l
0.81
11
20
122
676
2.06
10.11
3.5
2.6
0.98
1.11
e6/l
0.19
71
334
135
780
1.99
9.94
4.4
3.9
161.90
444.15
ng/l
1.74
101
585
384
3097
1.95
9.77
8.3
8.0
85.40
79.19
u/l
0.84
374
2946
144
859
1.94
9.63
1.8
1.6
1.43
1.33
mg/l
0.10
109
665
195
1299
1.81
9.14
3.8
3.1
18.31
53.80
e6/l
2.99
145
980
115
651
1.99
8.88
3.6
2.7
2.14
2.14
e6/l
0.00
64
310
203
1394
1.76
8.42
2.9
3.2
38.58
34.62
u/l
0.33
198
1332
76
376
2.20
8.36
3.7
2.4
37.10
39.17
u/l
0.11
59
313
212
1477
1.74
8.33
4.5
3.6
64.50
127.85
e6/l
1.04
146
1036
243
1765
1.72
8.18
7.6
6.7
1.20
1.21
mmol/l
0.79
236
1632
87
472
2.02
7.50
3.0
2.9
5.67
7.79
umol/l
1.23
78
429
98
562
1.92
7.18
2.7
2.4
2.31
2.26
g/l
0.44
93
526
172
1173
1.70
7.06
4.4
4.2
7.40
7.40
ph
0.06
127
836
451
3984
2.09
7.04
20.9
14.2
24.93
26.49
mg/l
0.48
396
3150
179
1236
1.69
7.00
2.7
2.4
—
—
—
0
0
231
1708
1.64
6.91
2.4
2.1
96.13
95.76
pmol/l
0.05
131
927
232
1724
1.63
6.76
2.6
2.4
78.10
76.45
nmol/l
0.36
212
1559
278
2166
1.62
6.63
6.1
7.2
11.60
12.27
umol/l
0.46
270
2073
267
2063
1.61
6.57
6.0
6.1
0.21
0.19
e9/l
1.05
241
1769
258
1979
1.61
6.53
7.9
7.3
1.21
1.21
mmol/l
0.39
235
1706
241
1833
1.59
6.22
6.2
5.8
57.94
57.16
%
0.50
234
1763
148
999
1.68
6.18
2.5
2.0
2.85
2.82
mg/l
0.04
132
836
28
100
2.90
6.09
3.0
2.8
5.36
2.83
index
0.34
14
58
241
1840
1.58
6.07
6.4
6.0
8.63
8.91
%
0.94
231
1724
78
440
1.91
5.97
2.0
1.7
—
—
—
0
0
180
1287
1.61
5.95
6.0
5.7
—
—
—
0
0
240
1838
1.57
5.92
6.3
5.9
3.08
2.85
%
0.74
232
1724
181
1300
1.61
5.86
4.0
3.3
30.34
46.92
mg/l
1.17
124
837
286
2284
1.57
5.85
7.8
10.2
4.17
4.08
e9/l
0.26
252
1963
255
1986
1.56
5.81
6.0
5.8
0.58
0.57
e9/l
0.13
229
1676
239
1835
1.57
5.79
13.9
12.1
1.27
1.24
inr
0.36
196
1534
255
1987
1.56
5.79
6.0
5.8
0.04
0.04
e9/l
0.16
231
1682
13
19
6.99
5.77
1.2
1.0
—
—
—
0
0
239
1839
1.56
5.72
6.5
5.9
0.66
0.68
%
0.16
231
1719
258
2025
1.55
5.61
6.1
5.8
1.80
1.96
e9/l
1.07
234
1753
189
1385
1.58
5.56
4.0
3.3
7.27
7.74
mmol/l
0.86
170
1200
169
1207
1.60
5.54
2.3
2.1
129.49
282.97
u/l
1.78
161
1149
163
1159
1.60
5.43
4.0
3.1
—
—
—
0
0
66
365
1.93
5.35
9.3
9.2
—
—
—
0
0
241
1878
1.53
5.33
6.3
6.0
27.07
27.49
%
0.26
235
1786
5
0
+∞
5.21
2.6
0.0
1.22
—
ug/l
—
5
0
156
1108
1.59
5.18
5.1
4.4
—
—
—
0
0
179
1325
1.54
4.92
4.5
4.0
11.49
8.90
mg/mmol
0.19
121
845
38
176
2.25
4.92
3.8
3.9
1.02
1.02
ratio
0.04
30
166
177
1311
1.53
4.83
3.1
2.5
69.28
68.09
u/l
0.02
169
1218
21
73
2.96
4.82
1.1
1.1
0.52
3.36
u/ml
1.21
15
39
215
1661
1.51
4.81
3.8
3.3
6.15
6.20
ph
0.27
121
977
237
1874
1.49
4.70
3.4
2.8
96.72
138.00
ug/l
3.45
221
1748
133
935
1.57
4.55
1.4
1.3
1.75
1.40
u/ml
0.12
26
266
330
2801
1.50
4.54
3.5
3.3
64.87
49.68
u/l
0.88
314
2654
52
281
1.95
4.52
2.6
2.5
6.15
6.01
ph
0.49
36
183
203
1573
1.48
4.37
2.4
2.1
—
—
—
0
0
124
866
1.57
4.34
2.6
2.6
8.67
6.30
e6/l
0.55
116
789
285
2363
1.46
4.31
6.4
5.0
6.95
6.76
mmol/l
0.66
270
2240
17
56
3.11
4.28
1.1
1.2
2.75
3.33
u/ml
—
8
24
55
309
1.87
4.26
1.8
2.2
0.00
0.08
estimate
—
9
65
78
487
1.71
4.26
1.8
2.6
105.31
139.60
ug/g
0.78
56
396
116
805
1.57
4.16
1.5
1.4
2.66
2.52
g/l
0.23
71
505
257
2099
1.45
4.15
4.2
3.6
0.00
0.03
estimate
1.06
33
392
176
1346
1.47
3.97
2.8
3.9
2.33
2.36
mmol/l
1.87
162
1230
27
119
2.34
3.94
1.9
1.4
238.32
284.15
ug/g
0.42
15
72
41
215
1.99
3.90
1.3
1.3
84.66
48.54
au/ml
—
5
19
132
1752
0.67
3.85
2.8
3.1
—
—
—
0
0
358
3137
1.47
3.83
4.6
4.1
14.65
14.74
pmol/l
0.33
329
2890
63
385
1.73
3.72
8.8
8.0
1.29
1.38
mmol/l
0.32
63
377
253
2091
1.41
3.67
4.2
3.5
0.00
0.00
estimate
-0.00
37
418
220
1774
1.42
3.67
9.8
10.6
0.00
0.00
e9/l
0.28
188
1425
47
265
1.85
3.62
1.3
1.6
—
—
—
0
0
18
68
2.71
3.60
1.1
1.2
—
—
—
0
0
108
771
1.51
3.37
3.3
2.8
528.92
528.62
mosm/kgh2o
0.00
95
672
16
59
2.77
3.35
1.0
1.1
2.11
1.63
u/ml
—
9
22
34
178
1.97
3.27
2.4
1.8
0.22
0.36
mg/l
0.89
18
87
72
472
1.61
3.27
8.7
8.2
0.74
1.06
mmol/l
0.36
61
383
248
2072
1.38
3.24
4.2
3.5
0.00
0.00
estimate
0.50
37
415
55
338
1.70
3.20
2.4
2.5
7.21
7.87
ug/l
0.13
47
297
24
111
2.22
3.17
2.1
1.6
26.96
9.00
iu/ml
—
5
30
24
111
2.22
3.17
1.2
1.2
—
—
—
0
0
210
1716
1.38
3.11
1.9
1.9
1.34
1.34
mmol/l
0.05
190
1455
411
3755
1.48
3.09
5.9
5.0
1.92
1.95
mu/l
0.12
392
3477
16
62
2.63
3.07
1.0
1.1
11.25
7.36
u/ml
—
9
27
71
474
1.58
2.99
8.9
8.2
7.43
7.42
ph
0.75
33
261
42
244
1.79
2.97
2.0
2.8
—
—
—
0
0
151
1182
1.39
2.86
3.7
3.2
923.07
1286.04
ng/l
1.65
129
1002
12
39
3.13
2.79
1.7
2.2
—
—
—
0
0
47
288
1.70
2.78
4.9
3.8
104.04
80.88
ng/l
0.47
40
260
5
6
8.40
2.75
1.0
1.0
—
—
—
0
0
26
132
2.02
2.75
1.2
1.2
—
—
—
0
0
142
1108
1.39
2.72
1.9
1.7
24.03
19.97
nmol/l
2.09
128
934
35
201
1.80
2.59
1.1
1.1
—
—
—
0
0
11
36
3.10
2.58
1.4
1.1
—
—
—
0
0
8
20
4.05
2.57
1.0
1.5
—
—
—
0
0
123
945
1.40
2.57
4.5
3.6
1.02
1.02
kg/l
0.55
84
610
58
384
1.58
2.55
2.2
2.3
0.22
0.21
g/l
0.07
50
366
12
45
2.71
2.46
1.0
1.0
0.68
0.66
u/ml
—
7
12
15
64
2.38
2.41
3.1
1.7
—
—
—
0
0
14
58
2.45
2.39
1.0
1.1
1.76
2.55
u/ml
—
9
30
32
184
1.79
2.38
2.2
2.2
—
—
—
0
0
13
52
2.54
2.37
1.0
1.0
7.70
3.01
u/ml
—
8
24
16
71
2.29
2.36
1.3
1.1
—
—
—
0
0
27
148
1.87
2.33
2.2
1.9
—
—
—
0
0
48
312
1.59
2.29
1.2
1.2
—
—
—
0
0
74
530
1.46
2.27
1.5
1.7
—
—
—
0
0
414
3859
1.38
2.17
7.2
6.0
40.57
39.43
mmol/mol
1.51
396
3606
102
784
1.38
2.12
1.9
3.1
2.42
2.45
mmol/l
1.03
86
712
445
4204
1.44
2.10
16.9
13.0
—
—
—
0
0
7
20
3.53
2.06
1.1
5.5
1137.71
786.70
u/ml
—
7
20
421
3946
1.37
2.03
5.1
4.8
6.12
5.95
mmol/l
1.50
404
3636
17
83
2.08
2.03
1.2
1.3
—
—
—
0
0
12
51
2.39
1.96
1.0
1.0
4.77
4.48
u/ml
—
7
21
28
166
1.73
1.91
1.1
1.2
—
—
—
0
0
60
429
1.45
1.88
2.0
2.8
1.69
1.83
%
0.79
54
386
92
713
1.35
1.82
2.9
3.5
0.80
0.83
mmol/l
0.99
86
676
66
485
1.41
1.79
1.6
1.5
—
—
—
0
0
184
1575
1.26
1.74
4.3
3.7
25.79
64.67
ng/l
1.05
123
1108
160
1349
1.27
1.71
3.5
3.5
—
0.80
—
0
5
56
405
1.43
1.67
1.5
1.7
—
—
—
0
0
6
19
3.18
1.66
3.5
2.3
—
—
—
0
0
83
646
1.34
1.60
1.7
1.9
—
—
—
0
0
452
4324
1.38
1.58
13.1
10.8
26.05
26.53
u/l
0.27
447
4202
11
50
2.23
1.58
1.1
1.3
—
—
—
0
0
25
153
1.67
1.56
2.6
1.8
—
—
—
0
0
25
153
1.67
1.56
2.6
1.7
—
—
—
0
0
15
78
1.95
1.55
2.4
4.9
—
—
—
0
0
465
4473
1.42
1.54
29.6
21.8
255.12
248.78
e9/l
1.21
460
4361
25
154
1.66
1.53
2.6
1.8
—
—
—
0
0
25
154
1.66
1.53
2.6
1.8
—
—
—
0
0
11
51
2.18
1.51
2.2
1.8
19.30
27.71
ng/l
0.49
11
51
23
139
1.69
1.51
2.6
1.8
—
—
—
0
0
465
4476
1.42
1.50
29.6
21.8
4.44
4.52
e12/l
2.93
459
4356
465
4476
1.42
1.50
29.6
21.9
6.67
6.67
e9/l
0.00
459
4352
12
58
2.09
1.50
1.3
2.2
—
—
—
0
0
35
236
1.52
1.49
4.2
3.7
24.72
24.02
mmol/l
0.79
35
231
59
441
1.38
1.47
3.5
3.7
3.95
5.95
e9/l
0.90
51
392
465
4479
1.41
1.46
29.8
22.0
133.28
136.24
g/l
4.15
465
4418
34
230
1.51
1.43
2.7
3.6
4.63
4.57
pmol/l
0.13
34
211
10
46
2.20
1.40
1.1
1.1
—
—
—
0
0
9
40
2.27
1.40
1.0
1.1
—
—
—
0
0
7
29
2.43
1.39
1.1
1.1
69.60
36.56
mg/l
—
7
23
28
183
1.56
1.37
2.9
3.6
11.68
20575.14
u/ml
0.81
22
164
5
17
2.96
1.36
1.4
1.1
—
—
—
0
0
70
546
1.33
1.35
5.9
5.4
1.07
1.02
mmol/l
0.84
65
500
8
34
2.37
1.29
1.5
1.4
—
—
—
0
0
69
542
1.32
1.27
1.2
1.3
—
—
—
0
0
8
35
2.31
1.27
1.4
1.4
—
—
—
0
0
19
115
1.68
1.26
2.7
3.5
2.93
2.19
ratio
0.18
14
63
53
401
1.36
1.25
5.6
3.7
1.98
1.64
mmol/l
0.31
48
327
19
116
1.66
1.23
2.7
1.5
—
—
—
0
0
30
205
1.49
1.23
1.0
1.1
—
—
—
0
0
5
19
2.65
1.22
2.4
2.9
484.60
519.62
min
—
5
13
58
448
1.33
1.21
3.8
4.6
15.66
29.35
ug/l
0.38
44
384
8
38
2.12
1.19
3.5
3.1
—
—
—
0
0
17
103
1.67
1.14
1.2
1.2
—
—
—
0
0
7
32
2.20
1.08
1.6
1.2
—
—
—
0
0
14
82
1.73
1.06
1.4
2.1
—
—
—
0
0
44
334
1.35
1.04
1.7
3.0
69.31
69.47
e9/l
0.01
27
244
430
4137
1.24
1.04
6.4
5.6
2.68
2.76
mmol/l
1.21
409
3866
5
22
2.28
1.03
1.2
1.0
—
—
—
0
0
10
177
0.56
1.03
1.0
1.2
1.54
1.56
g/l
—
10
177
53
415
1.31
1.02
5.6
3.8
7.38
7.38
ph
0.24
37
232
14
84
1.69
0.98
1.1
1.0
—
—
—
0
0
76
628
1.25
0.97
1.6
1.7
1137.83
1178.07
nmol/l
0.17
61
480
21
304
0.68
0.96
3.1
3.5
—
—
—
0
0
424
4083
1.22
0.95
5.4
4.9
4.56
4.69
mmol/l
1.88
414
3829
6
28
2.16
0.91
2.8
1.2
78.00
77.86
umol/l
—
6
28
11
179
0.61
0.86
1.0
1.2
0.86
0.93
g/l
0.44
11
179
18
121
1.51
0.83
1.1
1.1
—
83.08
—
0
13
36
276
1.33
0.83
1.4
1.2
—
—
—
0
0
6
32
1.88
0.82
2.8
3.8
304.17
755.78
mg
—
6
32
14
89
1.59
0.82
1.9
2.6
2.30
2849.22
u/l
—
5
38
27
198
1.38
0.82
1.3
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
0
27
0.00
0.77
0.0
1.3
—
—
—
0
0
6
34
1.77
0.76
1.0
1.6
2.55
1.20
promille
—
6
27
50
407
1.25
0.75
1.5
1.4
—
—
—
0
0
5
24
2.09
0.74
1.0
1.2
111.20
140.63
nmol/l
—
5
24
129
1153
1.16
0.73
1.5
1.4
—
—
—
0
0
5
26
1.93
0.71
1.4
2.0
—
—
—
0
0
5
27
1.86
0.68
1.0
1.0
—
—
—
0
0
419
4064
1.17
0.68
5.2
4.8
1.44
1.46
mmol/l
0.38
404
3776
12
78
1.55
0.66
6.1
3.5
7.86
8.30
mmol/l
0.23
12
73
54
452
1.22
0.65
1.4
1.4
—
—
—
0
0
48
397
1.23
0.65
1.3
1.5
—
—
—
0
0
15
105
1.44
0.60
2.7
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
38.5
—
125.40
—
0
15
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
174
1610
1.12
0.59
4.2
3.5
0.00
0.02
estimate
1.23
25
340
6
35
1.72
0.58
1.2
1.0
—
—
—
0
0
10
65
1.55
0.56
1.5
1.3
0.15
0.42
nmol/l
—
10
52
27
216
1.26
0.50
2.5
2.9
48.26
91.43
u/ml
0.32
27
209
7
45
1.56
0.49
1.3
1.5
—
—
—
0
0
7
45
1.56
0.49
1.1
1.4
—
—
—
0
0
7
46
1.53
0.48
2.3
1.8
—
—
—
0
0
7
46
1.53
0.48
1.6
1.5
34.43
31.38
g/l
—
7
40
17
222
0.76
0.48
1.8
1.6
—
—
—
0
0
92
835
1.12
0.44
2.6
3.1
0.65
0.82
ug/l
1.30
54
508
11
78
1.42
0.43
1.0
1.0
—
—
—
0
0
6
92
0.65
0.42
1.0
1.8
—
—
—
0
0
28
337
0.82
0.42
5.1
5.7
0.22
0.22
%
—
9
92
5
32
1.57
0.42
2.0
1.7
1.76
3.64
mg/l
—
5
32
0
15
0.00
0.41
0.0
1.2
—
338.60
—
0
10
0
16
0.00
0.41
0.0
1.3
—
8.94
—
0
16
5
34
1.48
0.40
1.8
1.2
—
—
—
0
0
8
60
1.34
0.40
1.1
1.4
—
—
—
0
0
8
60
1.34
0.40
1.1
1.4
—
—
—
0
0
8
60
1.34
0.40
1.1
1.4
—
—
—
0
0
8
60
1.34
0.40
1.1
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
0.00
—
0
18
397
3879
1.10
0.40
4.4
4.1
1.33
1.29
mmol/l
0.54
377
3582
7
105
0.66
0.39
2.0
1.7
166.86
235.00
pmol/l
—
7
97
5
35
1.43
0.39
1.0
1.2
—
—
—
0
0
5
37
1.35
0.37
1.6
1.1
—
—
—
0
0
29
245
1.19
0.36
6.8
4.3
—
—
—
0
0
19
153
1.25
0.36
2.8
2.8
—
—
—
0
0
29
339
0.85
0.34
5.1
5.3
0.10
0.13
%
—
10
103
90
830
1.10
0.34
1.6
1.7
122078333.70
41607312.48
pmol/l
0.29
77
697
13
101
1.29
0.32
6.5
3.2
1.56
1.55
mmol/l
0.03
13
95
7
52
1.35
0.31
1.4
1.3
—
—
—
0
0
7
54
1.30
0.30
1.0
1.2
—
—
—
0
0
147
1395
1.08
0.29
4.7
5.3
1.99
3.46
ug/l
1.22
126
1256
38
427
0.88
0.28
1.3
1.4
—
—
—
0
0
10
128
0.78
0.27
3.5
3.9
1.17
1.41
mg/l
—
10
116
8
67
1.20
0.26
2.3
3.8
0.81
0.79
nmol/l
—
8
52
56
516
1.10
0.23
1.3
1.2
—
—
—
0
0
11
135
0.81
0.22
24.5
8.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
37.22
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
5.58
—
0
12
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
31.81
—
0
9
6
49
1.23
0.20
1.7
2.9
3.77
4.08
e9/l
—
6
49
33
298
1.11
0.20
1.3
1.8
—
—
—
0
0
6
53
1.13
0.18
1.0
1.1
—
—
—
0
0
35
382
0.91
0.17
1.6
1.5
—
—
—
0
0
39
423
0.92
0.17
2.0
1.5
—
—
—
0
0
10
82
1.22
0.17
1.5
1.7
—
—
—
0
0
10
82
1.22
0.17
3.2
2.3
3.67
5.07
mmol/24h
—
10
72
17
194
0.87
0.17
3.8
3.6
—
—
—
0
0
8
71
1.13
0.16
1.1
1.3
—
—
—
0
0
9
79
1.14
0.15
3.2
2.8
—
—
—
0
0
38
355
1.08
0.13
5.6
4.3
7.33
7.37
ph
0.31
33
264
112
1153
0.96
0.11
4.3
3.6
0.00
0.01
estimate
0.80
33
383
13
115
1.13
0.10
1.2
1.3
—
—
—
0
0
5
45
1.11
0.10
1.2
2.1
13.56
10.39
%
—
5
45
5
45
1.11
0.10
1.4
1.3
0.16
0.19
nmol/l
—
5
29
5
46
1.09
0.09
1.4
1.3
—
—
nmol/l
—
0
0
5
47
1.06
0.09
2.6
4.3
—
—
—
0
0
34
360
0.94
0.09
4.7
5.1
1.60
0.94
%
0.33
15
123
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
7
64
1.09
0.08
1.0
1.2
—
11.72
—
0
13
8
74
1.08
0.07
1.8
2.9
55.93
57.33
%
—
8
74
8
76
1.05
0.07
1.9
2.8
4.33
8.63
pmol/l
—
8
76
8
77
1.04
0.07
1.1
1.1
—
—
—
0
0
8
77
1.04
0.07
1.1
1.1
—
—
—
0
0
8
78
1.03
0.07
2.0
1.5
—
—
—
0
0
15
163
0.92
0.07
2.3
2.4
0.00
0.02
estimate
—
7
53
114
1160
0.98
0.05
3.3
3.0
0.00
0.02
estimate
1.15
24
321
12
110
1.09
0.05
8.0
4.6
—
—
—
0
0
11
120
0.91
0.05
1.0
1.1
—
—
—
0
0
33
340
0.97
0.03
4.5
5.2
1.23
0.72
%
0.39
13
113
29
282
1.03
0.02
1.3
1.2
184.04
164.99
u/ml
0.10
12
113
13
123
1.06
0.01
1.4
1.3
—
—
—
0
0
91
906
1.01
0.00
4.1
5.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
2.21
—
0
6
0
5
0.00
-0.00
0.0
3.4
—
9.58
—
0
5
5
49
1.02
-0.00
1.2
1.4
—
—
—
0
0
6
62
0.97
-0.00
2.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
19.98
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
7.15
—
0
9
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
0.52
—
0
5
0
8
0.00
-0.00
0.0
2.0
—
2.56
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
9.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
4.68
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
3.4
2.8
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
58.89
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
77
0.91
-0.00
3.9
3.8
20.14
22.86
u/ml
—
7
77

Mortality – FinRegistry

Association

Association between endpoint M13_CONTRACTUREJOINT and mortality.

Females

Parameter HR [95% CI] p-value
M13_CONTRACTUREJOINT 1.246 [1.0, 1.56] 0.055
Birth year 0.997 [0.99, 1.01] 0.451

During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 1054 females with M13_CONTRACTUREJOINT died.

Males

Parameter HR [95% CI] p-value
M13_CONTRACTUREJOINT 1.31 [1.07, 1.6] 0.009
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 1179 males with M13_CONTRACTUREJOINT died.

Mortality risk

Mortality risk for people of age

years, who have M13_CONTRACTUREJOINT.

N-year risk Females Males
1 0.124% 0.248%
5 0.842% 1.646%
10 1.817% 4.002%
15 3.492% 7.282%
20 6.293% 11.894%

Relationships between endpoints

Index endpoint: M13_CONTRACTUREJOINT – Contracture of joint

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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