No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
262 |
4. Check minimum number of eventsNone |
262 |
5. Include endpointsNone |
262 |
6. Filter based on genotype QC (FinnGen only) |
244 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Atlantoaxial subluxation
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1586 | 993 | 576 |
| Only index persons | 1308 | 813 | 495 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 61.59 | 53.21 |
| Only index persons | 56.40 | 59.48 | 51.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 244 | 162 | 82 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | 53.82 | 52.76 | 55.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 250
- Matched controls
- 2500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L01BA01
ATC
methotrexate; systemic
130.1
245.7
128
20
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
51.7
213.7
144
64
M43.4
ICD-10 Finland
Other recurrent atlantoaxial subluxation
+∞
204.2
167
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
28.5
168.3
158
142
L88
ICPC
Rheumatoid/seropositive arthritis
41.2
143.0
94
36
L04AA13
ATC
[U] leflunomide
77.6
138.3
76
14
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
85.5
135.3
73
12
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
25.2
133.4
112
78
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
44.8
127.3
80
26
M43.3
ICD-10 Finland
Recurrent atlantoaxial subluxation with myelopathy
+∞
123.4
108
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
59.2
119.3
69
16
A07EC01
ATC
sulfasalazine; oral, rectal
21.3
118.1
107
85
P01BA02
ATC
hydroxychloroquine; oral
19.1
115.6
114
105
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
34.3
112.8
77
32
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
57.0
110.1
64
15
L04AX03
ATC
methotrexate; systemic
16.7
109.6
121
133
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
18.9
103.2
97
81
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
48.2
102.5
62
17
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
228.3
100.7
98
7
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
44.1
93.9
58
17
L04AA01
ATC
[U] ciclosporin
63.8
90.4
51
10
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
49.3
80.5
48
12
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
361.6
79.4
76
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
18.7
77.2
68
49
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
+∞
71.3
65
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
21.8
69.0
55
32
M48.0
ICD-10 Finland
Spinal stenosis
104.5
59.2
63
8
L04AX01
ATC
azathioprine; systemic
18.0
58.8
51
35
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
153.6
57.7
59
5
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
16.1
57.2
53
41
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
21.4
54.6
43
24
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
20.6
53.5
43
25
N03AX12
ATC
[U] gabapentin; oral
8.1
48.2
80
137
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
287.8
47.8
47
*
N03AX16
ATC
[U] pregabalin
6.9
46.4
98
215
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
9.6
45.9
62
83
M01CB01
ATC
sodium aurothiomalate; parenteral
118.3
45.6
48
5
N02AX02
ATC
tramadol; systemic, rectal
6.2
44.9
165
594
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
8.3
44.6
70
112
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
7.9
44.1
73
124
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.8
43.8
64
94
NDG30
NOMESCO Finland
Fusion of wrist, total
177.0
43.3
44
*
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
10.2
42.8
54
66
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
7.0
42.3
81
160
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
11.6
41.7
47
49
NA1AD
NOMESCO Finland
Cervical spine CT examination
12.7
40.2
42
39
M05BA07
ATC
risedronic acid; oral
16.0
39.9
36
26
H02AB06
ATC
prednisolone; systemic
6.3
39.4
188
816
M54.2
ICD-10 Finland
Cervicalgia
9.7
38.1
49
61
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
7.4
37.0
63
109
TQW40
NOMESCO Finland
Remowal of suture of skin
8.2
37.0
56
85
NF1AA
NOMESCO Finland
Hip X-ray examination
7.7
36.8
60
99
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
12.6
36.4
38
35
M43.1
ICD-10 Finland
Spondylolisthesis
111.5
35.8
38
*
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
209.2
35.8
36
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
13.4
35.0
35
30
M05BA04
ATC
alendronic acid; oral
6.5
33.7
66
131
H02AB04
ATC
methylprednisolone; systemic
5.8
33.6
78
182
M01AX01
ATC
nabumetone; oral
11.2
32.0
36
37
M05BX04
ATC
denosumab; parenteral
8.0
31.8
48
72
L04AB01
ATC
etanercept; parenteral
80.9
31.8
35
5
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
13.5
31.3
31
26
SPAT1229
SPAT
Assessment of need for aid
8.0
31.3
47
70
M01AB55
ATC
diclofenac, combinations; oral
8.7
31.2
43
58
H02AB08
ATC
triamcinolone; systemic
341.5
30.5
30
*
9522
FHL
Synovectomy
176.1
30.4
31
*
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
57.8
30.3
35
7
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
13.0
29.7
30
26
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
55.9
29.2
34
7
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.3
28.8
149
639
L28
ICPC
Limited function/disability (L)
4.6
28.4
91
274
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
163.2
28.3
29
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
34.8
28.1
36
12
H02AB07
ATC
prednisone; oral
5.3
28.1
69
167
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
70.4
27.7
31
5
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
39.1
27.3
34
10
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
156.9
27.2
28
*
M01AH01
ATC
celecoxib; oral
4.8
27.1
79
220
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
26.5
25
*
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
288.8
26.2
26
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
6.6
26.0
47
85
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
+∞
25.4
24
*
9284
FHL
Wrist ossification surgery
+∞
25.4
24
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
276.5
25.1
25
*
M54.4
ICD-10 Finland
Lumbago with sciatica
5.5
24.5
55
122
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
+∞
24.4
23
*
9527
FHL
Alloarthroplasty, implant or endoprosthesis
+∞
24.4
23
*
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
96.4
24.2
26
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
264.3
24.1
24
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
6.5
24.0
43
77
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.6
23.9
71
199
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
7.4
23.7
37
57
WX204
NOMESCO Finland
Axillary plexus blockaced
9.5
23.2
29
34
J01FF01
ATC
clindamycin; systemic
3.8
23.0
109
426
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
22.1
22.8
33
17
NDG76
NOMESCO Finland
Fusion of DIP joint
57.7
22.6
26
5
SPAT1148
SPAT
Treatment of chronic ulcer or burn
4.8
22.4
61
159
N02AA05
ATC
oxycodone; systemic
4.1
22.2
79
252
ZZH31
NOMESCO Finland
Bone allograft, small pieces
88.2
22.1
24
*
9531
FHL
Arthrodesis of the hand joint
240.1
22.0
22
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
126.1
22.0
23
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.1
21.9
42
80
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
8.7
21.7
29
37
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.5
21.3
140
666
7230B
ICD-9 Finland
Other disorders of cervical region, Spinal stenosis of cervical region[SUBLUXATIO ATLANTO-AXIALIS]
+∞
21.1
20
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
84.2
21.1
23
*
M01CB03
ATC
auranofin; oral
228.2
20.9
21
*
N02BF01
ATC
gabapentin; oral
5.9
20.6
41
81
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
52.8
20.6
24
5
M81.9
ICD-10 Finland
Osteoporosis, unspecified
6.9
20.4
34
56
N02BF02
ATC
pregabalin; oral
7.8
20.4
30
43
L04AB04
ATC
adalimumab; parenteral
32.0
20.1
26
9
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.4
20.1
31
47
9283
FHL
Subtalar joint ossification surgery (or triple)
+∞
20.1
19
*
R4120
NOMESCO Finland
Occupational therapy
5.9
19.8
39
76
S97
ICPC
Chronic ulcer skin
5.9
19.1
37
71
M43.0
ICD-10 Finland
Spondylolysis
204.7
18.8
19
*
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
48.0
18.6
22
5
A02BC01
ATC
omeprazole; systemic
3.4
18.5
99
408
NDG74
NOMESCO Finland
Fusion of first IP joint
193.1
17.8
18
*
N06AX21
ATC
duloxetine; oral
5.0
17.3
41
94
X59
ICD-10 Finland
Exposure to unspecified factor
3.6
17.3
72
252
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.8
17.3
25
35
L04AA24
ATC
abatacept; parenteral
68.2
17.0
19
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
16.7
80
305
L04AA11
ATC
[U] etanercept
181.6
16.7
17
*
NDG77
NOMESCO Finland
Other excision, reconstruction or fusion of joint of first finger
181.6
16.7
17
*
WX203
NOMESCO Finland
Infraclavicular plexus blockade
18.4
16.5
25
15
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
16.3
103
463
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
13.0
16.0
28
24
M54.5
ICD-10 Finland
Low back pain
3.2
16.0
89
371
NDC40
NOMESCO Finland
Secondary prosthetic replacement in of joint of finger or metacarpal
+∞
15.8
15
*
NDF60
NOMESCO Finland
Operation for osteochondritis of a joint of hand,v
+∞
15.8
15
*
9256
FHL
Synovectomy (knee 9311)
+∞
15.8
15
*
NDB78
NOMESCO Finland
Prosthetic replacement of several of finger or metacarpal
+∞
15.8
15
*
NDB60
NOMESCO Finland
Prosthetic replacement of MCP joint of finger
+∞
15.8
15
*
M01CC01
ATC
penicillamine; oral
+∞
15.8
15
*
M01AH02
ATC
rofecoxib; oral
3.9
15.7
53
160
L01
ICPC
Neck symptom/complaint
3.7
15.4
58
189
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
34.1
15.0
19
6
M05BA01
ATC
etidronic acid; systemic
85.2
14.7
16
*
9272
FHL
Metatarsophalangeal joint resection
85.2
14.7
16
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
14.7
14
*
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
14.7
14
*
M01AE03
ATC
ketoprofen; systemic, rectal
2.8
14.6
117
590
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
38.6
14.6
18
5
9289
FHL
Other measure in this category
158.9
14.6
15
*
M47.9
ICD-10 Finland
Spondylosis, unspecified
158.9
14.6
15
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
14.5
149
854
A02BC03
ATC
lansoprazole; oral
2.9
14.5
96
437
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
29.2
14.5
19
7
NDL52
NOMESCO Finland
Tenosynovectomy of hand
24.0
14.5
20
9
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.3
14.4
31
65
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
13.1
14.4
25
21
ZXA05
NOMESCO Finland
Left side
3.0
14.4
88
384
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.8
14.3
50
154
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
45.3
14.3
17
*
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
56.7
14.0
16
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.9
14.0
96
445
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.9
13.9
92
418
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.6
13.9
52
168
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.7
13.8
131
716
L04AA17
ATC
[U] adalimumab
79.6
13.7
15
*
L01BB01, ,
ATC
79.6
13.7
15
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
17.5
13.7
21
13
L04AC07
ATC
tocilizumab; parenteral
+∞
13.7
13
*
9260
FHL
Alloarthroplasty, endoprosthesis or implant
+∞
13.7
13
*
ZX120
NOMESCO Finland
Intravenous
4.0
13.6
43
123
L04AC14
ATC
sarilumab; systemic
147.7
13.6
14
*
3006
Kela drug reimbursment
Baricitinib
147.7
13.6
14
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
27.5
13.6
18
7
NH1AD
NOMESCO Finland
Ankle and foot CT
13.2
13.4
23
19
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
16.2
13.4
21
14
M54.9
ICD-10 Finland
Dorsalgia, unspecified
4.6
13.2
34
83
A02BC02
ATC
pantoprazole; systemic
3.2
13.2
199
1369
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
6.6
13.2
22
36
TNG10
NOMESCO Finland
Puncture of knee
20.4
13.1
19
10
WZA90
NOMESCO Finland
Other medical or dental certificate
2.9
13.1
80
346
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
5.6
13.0
26
51
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
52.9
13.0
15
*
SPAT1215
SPAT
Assessment of need for medical rehabilitation
6.4
12.8
22
37
B01AB05
ATC
enoxaparin; parenteral
2.7
12.8
109
560
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.0
12.8
70
285
Z50.1
ICD-10 Finland
Other physical therapy
5.5
12.7
26
52
NHG82
NOMESCO Finland
Fusion of other tarsal joint
21.4
12.7
18
9
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.2
12.6
37
100
M05.3
ICD-10 Finland
Rheumatoid arthritis with involvement of other organs and systems
+∞
12.6
12
*
M45
ICD-10 Finland
Ankylosing spondylitis
136.6
12.6
13
*
293
Kela drug reimbursment
Baricitinib
136.6
12.6
13
*
ZXA00
NOMESCO Finland
Right side
2.7
12.4
90
425
M79.6
ICD-10 Finland
Pain in limb
2.6
12.4
128
719
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
39.7
12.3
15
*
J01MA12
ATC
levofloxacin; systemic
3.1
12.3
64
252
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
12.3
50
170
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
19.3
12.2
18
10
ZXE20
NOMESCO Finland
More than three and less than five hours
3.3
12.2
54
193
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
5.3
12.2
26
54
L04AB06
ATC
golimumab; parenteral
49.2
12.0
14
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
49.2
12.0
14
*
M01AX17
ATC
nimesulide; oral
2.8
11.8
79
356
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
31.8
11.8
15
5
9165
FHL
Removal of osteosynthesis material
14.6
11.7
19
14
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
11.6
65
267
WX707
NOMESCO Finland
Fiberoscopic intubation
+∞
11.5
11
*
NCF10
NOMESCO Finland
Synovectomy of elbow joint, open
125.6
11.5
12
*
L04AA37
ATC
[U] baricitinib
125.6
11.5
12
*
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
125.6
11.5
12
*
J01MA02
ATC
ciprofloxacin; systemic
2.5
11.4
116
640
WZA10
NOMESCO Finland
Extensive medical or dental certificate
18.1
11.4
17
10
L03
ICPC
Low back symptom/complaint
2.7
11.4
77
349
NG1DA
NOMESCO Finland
X-ray of knees
21.2
11.3
16
8
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
26.4
11.3
15
6
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
4.4
11.0
29
72
M01AC06
ATC
meloxicam; systemic, rectal
2.5
11.0
110
601
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
18.9
10.9
16
9
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
18.9
10.9
16
9
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
10.9
43
143
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
10.8
120
685
M01AB01
ATC
indometacin; systemic, rectal
4.4
10.8
29
73
WX002
NOMESCO Finland
Sedation and analgesia
2.8
10.8
65
276
A02BC05
ATC
esomeprazole; systemic
2.4
10.8
118
670
R50.9
ICD-10 Finland
Fever, unspecified
3.0
10.7
56
220
9477
FHL
Cleansing or splitting of a tendon or tendon sheath (eg tenosynovectomy, tenolysis)
62.7
10.7
12
*
P01BA01
ATC
chloroquine; systemic
62.7
10.7
12
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.2
10.7
47
167
NH3EA
NOMESCO Finland
Feet X-ray examination with load
12.8
10.5
18
15
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.4
10.5
41
135
A02BB01
ATC
misoprostol; oral
114.6
10.5
11
*
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
114.6
10.5
11
*
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
114.6
10.5
11
*
RT271, ,
NOMESCO Finland
114.6
10.5
11
*
L04AB05
ATC
certolizumab pegol; parenteral
114.6
10.5
11
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.9
10.5
61
254
K07.60
ICD-10 Finland
Snapping jaw
4.9
10.5
24
53
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
10.5
47
169
NB2AT
NOMESCO Finland
Intra artrial injection of shoulder with ultrasound guidance
19.8
10.4
15
8
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.6
10.4
38
120
D06BB04
ATC
podophyllotoxin; topical
5.6
10.3
20
38
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
10.3
80
386
SPAT1153
SPAT
Removal of sutures
2.5
10.3
95
497
X58
ICD-10 Finland
Exposure to other specified factors
3.1
10.2
50
189
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
15.4
10.1
16
11
L17
ICPC
Foot/toe symptom/complaint
2.4
10.1
98
523
R06.0
ICD-10 Finland
Dyspnoea
2.5
10.1
87
440
L04AK01
ATC
leflunomide; oral
41.9
10.1
12
*
NHB10
NOMESCO Finland
Primary partial prosthetic replacement of ankle joint
41.9
10.1
12
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.6
10.0
35
107
M03BX01
ATC
baclofen; systemic
12.9
10.0
17
14
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
10.2
10.0
19
20
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
9.8
136
845
N03AE01
ATC
clonazepam; systemic
4.9
9.7
22
48
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
57.3
9.7
11
*
L01AA02
ATC
chlorambucil; oral
57.3
9.7
11
*
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
57.3
9.7
11
*
9271
FHL
Hallux surgery
10.7
9.7
18
18
NBB20
NOMESCO Finland
Primary total prosthetic replacement of humero-scapular joint
10.7
9.7
18
18
B01AB04
ATC
dalteparin; parenteral
5.0
9.5
21
45
9314
FHL
Total knee endoprosthesis (also includes patellar part)
103.8
9.5
10
*
291
Kela drug reimbursment
Tofacitinib
103.8
9.5
10
*
NBB10
NOMESCO Finland
Primary partial prosthetic replacement of humero-scapular joint not using cement, other or unspecified
22.7
9.4
13
6
NB1AD
NOMESCO Finland
Shoulder CT examination
11.3
9.4
17
16
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
9.4
9
*
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
+∞
9.4
9
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
9.4
9
*
N06AA09
ATC
amitriptyline; systemic
3.7
9.4
32
96
B02.9
ICD-10 Finland
Zoster without complication
3.7
9.4
32
96
M05BA06
ATC
ibandronic acid; systemic
8.3
9.3
20
26
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.8
9.3
52
211
M01AE02
ATC
naproxen; oral, rectal
2.3
9.3
156
1043
R13
ICD-10 Finland
Dysphagia
3.8
9.2
30
87
J01DB01
ATC
cefalexin; oral
3.2
9.1
219
1719
9473
FHL
Local soft tissue removal or exploration (eg Bursa)
38.2
9.1
11
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
38.2
9.1
11
*
ZZH20
NOMESCO Finland
Graft of patients own bone
38.2
9.1
11
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
9.1
43
159
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
7.3
9.1
21
31
J04AB02
ATC
rifampicin; systemic
25.1
9.0
12
5
L95
ICPC
Osteoporosis
4.4
8.9
23
56
M01AH05
ATC
etoricoxib; oral
2.3
8.9
161
1104
J01DA01
ATC
[U] cefalexin
2.3
8.8
165
1144
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.1
8.8
41
150
SPAT1149
SPAT
Suture or treatment of traumatic wound
3.1
8.8
41
150
M35.7
ICD-10 Finland
Hypermobility syndrome
51.8
8.7
10
*
J20
ICD-10 Finland
Acute bronchitis
3.2
8.6
37
129
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
28.6
8.6
11
*
3029
Kela drug reimbursment
Upadacitinib
93.1
8.5
9
*
NDG71
NOMESCO Finland
Arthrodes of first MP joint
93.1
8.5
9
*
298, ,
Kela drug reimbursment
93.1
8.5
9
*
NDF68
NOMESCO Finland
Operation for osteochondritis of several joints of hand, open
93.1
8.5
9
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
7.5
8.4
19
27
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
8.4
8
*
NDL99
NOMESCO Finland
Other operation on muscle or tendon of wrist or hand
+∞
8.4
8
*
L04AA29
ATC
[U] tofacitinib
+∞
8.4
8
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
+∞
8.4
8
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.8
8.4
27
78
R51.80
ICD-10 Finland
Headache
2.8
8.3
47
192
M03BC01
ATC
orphenadrine (citrate); systemic
2.5
8.2
59
271
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.7
8.2
27
79
ZX140
NOMESCO Finland
Intra articular
17.9
8.2
12
7
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
17.9
8.2
12
7
NDF10
NOMESCO Finland
Synovectomy of wrist
34.6
8.1
10
*
ZXC95
NOMESCO Finland
Use of surgical navigator
34.6
8.1
10
*
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.7
8.1
18
25
UJF32
NOMESCO Finland
Coloscopy
2.3
8.1
74
380
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
6.5
8.0
20
33
A28
ICPC
Limited function/disability NOS
2.5
8.0
60
281
R5110, ,
SPAT
3.2
8.0
34
118
S18
ICPC
Laceration/cut
2.1
7.9
131
851
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.6
7.9
27
81
M03BX02
ATC
tizanidine; oral
2.2
7.9
153
1056
R4180
NOMESCO Finland
Podiatric therapy
11.3
7.9
14
13
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.1
7.9
117
729
M54.3
ICD-10 Finland
Sciatica
6.8
7.9
19
30
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
7.8
54
243
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
7.8
7.8
17
23
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
7.8
7.8
17
23
XX9XE
NOMESCO Finland
Other ultrasound examination
15.7
7.8
12
8
L04AD01
ATC
ciclosporin; systemic
15.7
7.8
12
8
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
3.9
7.8
24
67
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.8
7.8
18
40
M05BX03
ATC
strontium ranelate; oral
46.5
7.8
9
*
NF2AT
NOMESCO Finland
Injection to hip joint with ultrasound guidance
46.5
7.8
9
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.0
7.7
36
132
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
19.1
7.7
11
6
NFC40
NOMESCO Finland
Repair of hip prosthesis by bone transplant to acetabulum
25.9
7.6
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
7.6
52
233
ZZH40
NOMESCO Finland
Substitute of bone
82.4
7.5
8
*
L04AA44
ATC
[U] upadacitinib
82.4
7.5
8
*
NDM99
NOMESCO Finland
Other operation on fascia, ganglion, synovial sheath or bursa of wrist or hand
82.4
7.5
8
*
WX320
NOMESCO Finland
Spinalanesthesy
2.2
7.4
79
430
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
8.8
7.4
15
18
AA1AD
NOMESCO Finland
CT of head and brain
2.2
7.4
84
469
H02BX01
ATC
methylprednisolone, combinations; systemic
4.4
7.4
19
46
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.4
7.4
28
90
M19.2
ICD-10 Finland
Other secondary arthrosis
11.4
7.4
13
12
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
9.8
7.4
14
15
WZC00
NOMESCO Finland
Treatment plan or consultation
2.1
7.4
104
632
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.9
7.4
22
60
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.7
7.3
43
178
L01CB
ATC
Podophyllotoxin derivatives
+∞
7.3
7
*
9311
FHL
Knee cleansing surgery (synovectomy, debridement)
+∞
7.3
7
*
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
7.3
7
*
Z98.1
ICD-10 Finland
Arthrodesis status
+∞
7.3
7
*
E85.3
ICD-10 Finland
Secondary systemic amyloidosis
+∞
7.3
7
*
R52.2
ICD-10 Finland
Other chronic pain
6.4
7.2
18
30
L99
ICPC
Musculoskeletal disease other
8.3
7.2
15
19
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
3.9
7.2
22
61
L83
ICPC
Neck syndrome
31.0
7.2
9
*
M17.4
ICD-10 Finland
Other secondary gonarthrosis, bilateral
31.0
7.2
9
*
NDL66
NOMESCO Finland
Transposition of tendon of wrist or hand, other tendon
31.0
7.2
9
*
H05AA02
ATC
teriparatide; parenteral
20.7
7.2
10
5
M50.3
ICD-10 Finland
Other cervical disc degeneration
20.7
7.2
10
5
SPAT1216
SPAT
Assessment of functional ability
2.5
7.2
49
219
N43.3
ICD-10 Finland
Hydrocele, unspecified
12.5
7.2
12
10
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
7.4
7.1
16
23
N02AC04
ATC
dextropropoxyphene; oral
7.4
7.1
16
23
L16
ICPC
Ankle symptom/complaint
2.8
7.1
38
150
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.2
7.1
18
31
Z2446
NOMESCO Finland
Social worker
3.6
7.0
24
72
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.3
6.9
18
44
G44.2
ICD-10 Finland
Tension-type headache
2.7
6.9
40
165
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.3
6.9
27
89
M02AA10
ATC
ketoprofen; topical
2.5
6.8
46
204
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
6.8
93
555
S72.3
ICD-10 Finland
Fracture of shaft of femur
17.3
6.8
10
6
318
Kela drug reimbursment
Teriparatide
17.3
6.8
10
6
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
17.3
6.8
10
6
M06
ICD-10 Finland
Other rheumatoid arthritis
17.3
6.8
10
6
7148X
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies
41.2
6.8
8
*
RT272, ,
NOMESCO Finland
41.2
6.8
8
*
UKC02
NOMESCO Finland
Cystoscopy
2.6
6.8
43
185
N05CF01
ATC
zopiclone; oral
2.1
6.8
91
540
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
6.8
81
460
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.6
6.7
23
69
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
8.2
6.7
14
18
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
6.6
101
627
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
10.4
6.6
12
12
-50
ICPC
Medication/prescr/renewal
5.6
6.6
18
34
Z02.7
ICD-10 Finland
Issue of medical certificate
3.3
6.6
26
86
WX110
NOMESCO Finland
Infiltration anesthesia
2.1
6.6
182
1393
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.9
6.5
32
120
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.4
6.5
49
229
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.0
6.5
30
109
Z3226
NOMESCO Finland
Physiotherapist
2.4
6.5
52
250
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
6.5
31
115
3005
Kela drug reimbursment
Tofacitinib
71.6
6.5
7
*
0103, ,
NOMESCO Finland
71.6
6.5
7
*
7143B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SEROPOSITIVA]
71.6
6.5
7
*
NHF80
NOMESCO Finland
Operation for debridement of toe joint, open
71.6
6.5
7
*
ZZH32
NOMESCO Finland
Bone allograft, block
71.6
6.5
7
*
XA402
NOMESCO Finland
ENMG
14.8
6.4
10
7
M81.8
ICD-10 Finland
Other osteoporosis
14.8
6.4
10
7
WZA00
NOMESCO Finland
Concise certificate
3.6
6.4
22
66
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.6
6.4
22
66
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
8.5
6.4
13
16
ZXD05
NOMESCO Finland
Urgent procedure
2.1
6.4
82
477
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
9.6
6.4
12
13
J05AB11
ATC
valaciclovir; oral
2.4
6.4
50
238
1222
FHL
Arthroscopy and synovial surgery
18.6
6.3
9
5
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.2
6.3
25
83
NCF20
NOMESCO Finland
Operation for osteochondritis of elbow joint, open
+∞
6.3
6
*
NAU20
NOMESCO Finland
Removal of internal fixation device from spine or neck
+∞
6.3
6
*
NDG79
NOMESCO Finland
Other excision, reconstruction or fusion of joint of II-V finger
+∞
6.3
6
*
9508
FHL
Tendon or muscle transposition
+∞
6.3
6
*
6960A
ICD-9 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
+∞
6.3
6
*
L01AA01
ATC
cyclophosphamide; systemic
27.4
6.3
8
*
NCM20
NOMESCO Finland
Excision of synovial ganglion of elbow or forearm
27.4
6.3
8
*
R60.0
ICD-10 Finland
Localized oedema
2.6
6.3
38
160
-, ,
ICD-10 Finland
8.0
6.2
13
17
M54
ICD-10 Finland
Dorsalgia
2.9
6.2
31
118
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
13.0
6.1
10
8
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
3.3
6.1
24
79
ND1AA
NOMESCO Finland
Wrist X-ray examination
2.9
6.1
29
107
N03AX09
ATC
lamotrigine; oral
4.1
6.1
17
44
W19
ICD-10 Finland
Unspecified fall
2.8
6.1
31
119
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
6.1
37
156
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
6.1
52
257
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
6.0
88
534
R4110, ,
SPAT
2.5
6.0
40
176
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
51
11.71
43.59
2.1
1.3
—
—
—
0
0
49
54
11.04
41.83
2.5
1.4
15014.94
18331.08
e6/l
0.09
36
37
45
64
8.36
31.20
1.8
1.4
2.51
0.00
iu/ml
—
8
11
171
986
3.32
17.77
3.6
2.4
80.51
79.42
nmol/l
0.18
160
879
193
1201
3.66
17.58
20.9
10.0
4.38
4.02
e9/l
1.74
186
1044
116
540
3.14
17.46
3.1
2.2
3.60
3.01
mg/l
1.97
105
459
181
1131
3.18
15.37
7.9
3.7
0.00
0.00
estimate
-0.00
53
251
26
44
6.48
15.12
2.1
1.5
—
—
—
0
0
179
1123
3.09
14.87
8.0
3.7
0.00
0.00
estimate
-0.00
54
240
223
1598
4.66
14.86
15.1
4.0
14.38
12.42
mm/h
1.14
218
1462
179
1138
3.02
14.22
8.2
3.7
0.00
0.01
estimate
0.50
50
232
117
633
2.59
12.21
8.0
3.7
0.00
0.00
estimate
0.50
52
232
21
19
11.95
11.78
1.1
1.0
—
—
—
0
0
156
990
2.53
11.30
6.8
6.5
1.21
1.22
mmol/l
0.48
147
917
169
1114
2.60
11.27
8.5
7.3
1.21
1.22
mmol/l
0.12
147
951
74
340
2.67
10.54
2.2
1.9
—
—
—
0
0
147
941
2.36
9.97
5.0
4.5
33.43
35.63
g/l
4.00
142
894
152
989
2.37
9.90
3.8
2.7
—
—
estimate
—
0
0
77
371
2.55
9.88
2.4
2.3
11.24
13.10
umol/l
1.15
72
348
74
359
2.51
9.29
1.8
1.6
1075.51
1138.96
nmol/l
0.22
57
262
212
1643
2.91
8.89
16.6
8.1
73.13
79.83
u/l
2.23
207
1544
41
152
3.03
8.60
1.8
1.5
—
—
—
0
0
71
349
2.44
8.60
2.3
2.2
2.34
2.33
g/l
0.05
64
325
144
974
2.13
7.80
4.0
2.9
106.99
121.02
ug/l
0.58
137
903
52
231
2.58
7.74
4.2
9.2
1.17
1.29
mmol/l
0.05
41
197
129
843
2.10
7.59
8.4
3.7
0.00
0.02
estimate
0.80
43
200
55
256
2.47
7.40
1.9
1.8
—
—
—
0
0
65
330
2.31
7.19
2.3
2.2
20.39
22.52
%
0.45
59
311
123
806
2.04
7.02
5.0
3.7
3223.53
45.56
ng/l
0.49
98
594
27
94
3.10
6.27
1.5
2.5
8.34
5.78
iu/ml
—
5
21
57
290
2.25
6.21
5.7
8.1
104.09
104.08
mmol/l
0.00
57
290
87
527
2.00
5.99
3.2
2.4
—
—
—
0
0
19
56
3.59
5.71
1.7
1.5
—
—
—
0
0
11
13
8.79
5.62
1.9
1.5
—
—
—
0
0
100
651
1.89
5.48
2.3
2.4
52.24
67.11
u/l
1.30
95
597
78
471
1.95
5.33
8.2
3.6
1.02
1.02
kg/l
0.53
60
323
21
71
3.14
5.12
3.2
2.6
—
—
—
0
0
103
690
1.84
5.07
3.3
3.4
1202.50
1311.03
ng/l
0.14
88
593
45
228
2.19
4.90
3.4
3.0
—
—
—
0
0
98
653
1.82
4.87
2.0
1.6
19.96
20.62
nmol/l
0.16
83
537
20
69
3.06
4.72
1.4
1.3
—
—
—
0
0
131
959
1.77
4.69
2.5
2.0
92.42
98.19
pmol/l
0.59
71
494
18
59
3.21
4.62
1.3
3.2
1.10
2.24
ratio
0.68
13
28
46
241
2.11
4.59
2.0
1.8
—
—
—
0
0
94
628
1.80
4.57
7.4
3.4
0.00
0.01
estimate
0.50
43
195
13
28
4.84
4.43
1.4
1.9
—
—
—
0
0
19
67
2.99
4.33
1.3
1.2
—
—
—
0
0
29
129
2.41
4.25
1.9
1.6
—
—
—
0
0
59
351
1.89
4.11
1.4
1.3
140.72
17.06
u/ml
0.81
28
134
13
31
4.36
4.07
1.3
1.1
6.57
4.27
u/ml
—
7
15
85
570
1.74
3.99
5.1
3.0
0.31
0.48
e6/l
0.35
74
415
72
460
1.79
3.99
1.7
1.7
414.05
441.35
pmol/l
0.36
61
369
94
650
1.71
3.95
3.2
2.0
132.47
212.28
u/l
1.54
94
617
14
38
3.84
3.86
1.6
2.2
—
—
—
0
0
147
1152
1.67
3.80
5.2
6.7
9.45
11.20
umol/l
2.73
142
1098
62
384
1.82
3.79
1.4
1.3
87.79
34.34
iu/ml
1.66
32
127
107
773
1.67
3.78
2.4
3.6
2.34
2.36
mmol/l
1.11
99
702
12
29
4.29
3.75
1.0
1.1
—
—
—
0
0
12
29
4.29
3.75
1.2
1.2
10.67
1.25
u/ml
—
6
12
18
68
2.77
3.65
2.1
1.9
—
—
—
0
0
19
75
2.66
3.55
2.2
2.1
—
—
—
0
0
11
26
4.38
3.55
1.5
2.0
—
—
—
0
0
27
128
2.24
3.45
5.1
12.4
95.91
94.28
%
1.49
27
128
77
521
1.69
3.43
3.2
2.8
332.80
345.43
umol/l
0.50
69
460
8
15
5.47
3.21
2.1
1.1
—
—
—
0
0
27
134
2.14
3.10
4.7
11.8
0.58
0.67
%
0.56
27
134
8
16
5.13
3.07
1.3
1.3
—
—
—
0
0
28
144
2.06
2.94
1.1
1.3
130.74
204.87
u/ml
0.35
11
63
16
64
2.60
2.93
1.8
1.9
—
—
—
0
0
40
239
1.80
2.72
7.4
6.2
—
—
—
0
0
14
55
2.64
2.66
1.8
1.8
—
—
—
0
0
28
150
1.98
2.64
2.2
2.3
7.31
7.08
ug/l
0.03
20
140
66
457
1.60
2.62
1.9
1.6
1.49
1.37
mg/l
0.15
51
360
15
62
2.51
2.59
1.9
1.8
—
—
—
0
0
15
62
2.51
2.59
1.3
2.0
—
—
—
0
0
5
7
7.26
2.56
1.0
1.1
—
—
—
0
0
6
11
5.56
2.56
1.5
1.1
—
—
—
0
0
32
182
1.87
2.54
7.1
7.0
7.71
9.05
mmol/l
0.68
32
171
53
352
1.64
2.48
4.7
3.4
0.80
0.81
mmol/l
0.33
53
338
6
12
5.09
2.41
1.0
2.0
—
—
—
0
0
6
12
5.09
2.41
1.0
2.0
—
—
—
0
0
6
12
5.09
2.41
1.0
2.0
—
—
—
0
0
21
106
2.07
2.33
1.4
1.3
—
—
—
0
0
35
212
1.76
2.28
5.4
4.0
5.71
5.79
kpa
0.20
35
203
7
18
3.97
2.27
1.0
1.1
—
—
—
0
0
226
2089
1.85
2.20
39.7
14.4
18.32
23.99
mg/l
3.58
217
1683
14
61
2.37
2.19
1.2
1.2
—
—
—
0
0
31
186
1.76
2.09
5.7
3.6
4.31
4.45
kpa
0.21
31
179
10
37
2.77
2.09
1.8
2.9
15.55
16.33
%
—
10
37
6
15
4.07
2.05
1.0
1.1
—
—
—
0
0
28
165
1.78
2.01
3.3
3.0
68.33
59.07
ml/min/173m2
0.51
15
73
7
21
3.40
1.98
1.0
1.1
—
—
—
0
0
6
16
3.81
1.94
1.0
1.9
—
—
—
0
0
6
16
3.81
1.94
1.0
1.1
—
—
—
0
0
6
16
3.81
1.94
1.0
1.9
—
—
—
0
0
6
16
3.81
1.94
1.0
1.9
—
—
—
0
0
6
16
3.81
1.94
1.0
1.9
—
—
—
0
0
8
28
2.92
1.88
1.0
1.8
—
—
—
0
0
8
28
2.92
1.88
1.0
1.8
—
—
—
0
0
8
28
2.92
1.88
1.0
1.8
—
—
—
0
0
6
17
3.59
1.85
1.0
1.1
—
—
—
0
0
6
17
3.59
1.85
1.0
1.1
—
—
—
0
0
12
53
2.33
1.83
2.1
1.7
—
—
—
0
0
49
344
1.53
1.81
4.7
2.6
1.28
1.36
e6/l
0.07
31
183
6
19
3.21
1.67
1.0
1.1
—
—
—
0
0
13
63
2.12
1.63
2.1
1.8
6.23
5.95
iu/l
—
8
21
13
63
2.12
1.63
1.3
1.1
—
—
—
0
0
47
335
1.50
1.62
2.2
1.8
29.72
29.43
s
0.10
47
326
185
1670
1.41
1.61
5.4
4.4
15.50
14.93
pmol/l
2.18
175
1514
10
43
2.38
1.61
2.5
2.3
6.32
8.16
pmol/l
—
10
43
10
43
2.38
1.61
1.8
1.7
—
—
—
0
0
66
504
1.42
1.60
1.4
1.3
4.35
1.23
u/ml
0.42
27
132
6
20
3.05
1.59
2.0
1.4
—
—
—
0
0
16
85
1.94
1.59
1.7
1.9
—
—
—
0
0
90
727
1.37
1.57
3.3
3.0
26.79
33.35
u/l
1.80
85
686
9
38
2.42
1.47
1.8
1.8
—
—
—
0
0
5
16
3.17
1.44
1.0
1.1
—
—
—
0
0
45
327
1.46
1.42
5.0
2.7
4.95
3.11
e6/l
0.58
28
167
10
46
2.22
1.42
1.2
1.2
—
—
—
0
0
7
29
2.45
1.40
1.3
1.4
—
—
—
0
0
7
29
2.45
1.40
1.3
1.4
—
—
—
0
0
7
29
2.45
1.40
1.3
1.4
—
—
—
0
0
19
112
1.75
1.40
1.1
1.0
—
—
—
0
0
6
23
2.65
1.37
2.7
1.9
-0.30
0.91
mmol/l
—
6
23
14
75
1.92
1.37
1.6
1.6
—
—
—
0
0
14
75
1.92
1.37
3.0
3.2
24.82
26.08
mmol/l
0.71
14
75
10
47
2.17
1.35
1.7
1.8
—
—
—
0
0
12
62
1.98
1.30
1.4
1.4
0.00
0.00
g/l
-0.00
12
56
11
55
2.05
1.29
1.8
1.4
—
—
—
0
0
5
18
2.81
1.29
1.0
1.0
—
—
—
0
0
6
25
2.43
1.25
2.2
1.9
8.95
10.84
mmol/l
—
6
25
6
25
2.43
1.25
2.5
1.6
—
—
—
0
0
6
25
2.43
1.25
2.2
1.9
—
—
—
0
0
12
63
1.95
1.25
1.2
1.1
—
—
—
0
0
5
19
2.66
1.22
2.4
3.8
10.26
3.28
nmol/l
—
5
19
6
26
2.34
1.19
2.7
4.5
—
—
—
0
0
158
1426
1.29
1.16
4.0
3.0
58.22
46.86
u/l
0.72
152
1338
5
20
2.53
1.15
1.0
1.2
74.20
114.60
pmol/l
—
5
20
13
73
1.82
1.13
2.3
3.9
1.22
1.35
mmol/l
0.23
13
73
19
122
1.60
1.06
1.1
1.2
—
65.90
—
0
8
7
37
1.92
0.95
1.3
1.9
—
—
—
0
0
7
37
1.92
0.95
1.0
1.1
—
—
—
0
0
6
27
2.25
0.94
1.0
1.0
—
—
—
0
0
6
27
2.25
0.94
1.8
2.0
—
—
—
0
0
6
27
2.25
0.94
1.3
1.5
—
—
—
0
0
6
27
2.25
0.94
1.3
1.5
—
—
—
0
0
9
52
1.76
0.93
1.7
1.3
—
—
—
0
0
6
28
2.17
0.92
1.0
1.0
—
—
—
0
0
6
28
2.17
0.92
1.3
1.5
—
—
—
0
0
6
30
2.02
0.87
1.2
1.7
—
—
—
0
0
135
1221
1.23
0.87
3.1
2.8
—
—
—
0
0
12
72
1.70
0.87
1.1
1.3
—
—
—
0
0
217
2073
1.35
0.86
27.8
14.7
83.30
79.83
ml/min/173m2
1.69
205
1910
8
45
1.80
0.85
1.0
1.1
—
66.63
—
0
6
17
113
1.54
0.84
3.1
2.5
14.56
12.51
nmol/l
0.80
17
104
7
38
1.87
0.74
1.7
1.4
—
—
—
0
0
5
26
1.94
0.71
1.2
1.2
—
—
—
0
0
9
58
1.57
0.70
2.0
1.6
561.67
344.36
mu/l
—
9
51
38
307
1.28
0.66
4.5
4.7
33.38
32.33
%
0.20
26
194
10
62
1.64
0.66
2.3
4.4
3.75
4.04
mmol/l
—
10
62
40
328
1.26
0.62
1.6
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
467.75
—
0
16
0
22
0.00
0.59
0.0
1.1
—
46.74
—
0
16
21
158
1.36
0.59
2.1
1.9
—
—
—
0
0
6
37
1.64
0.56
1.3
1.3
—
—
—
0
0
6
37
1.64
0.56
1.3
1.3
—
—
—
0
0
206
1984
1.22
0.54
6.6
5.3
1.79
1.93
mu/l
1.12
192
1810
22
171
1.31
0.52
1.7
1.4
—
—
—
0
0
13
93
1.42
0.49
1.3
1.4
—
—
—
0
0
210
2033
1.21
0.47
4.5
4.2
1.27
1.24
mmol/l
0.38
197
1845
85
929
0.87
0.45
2.0
1.9
1.50
1.30
mmol/l
1.40
70
766
22
176
1.27
0.43
2.2
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
2.6
—
13.23
—
0
17
39
336
1.19
0.40
1.4
1.5
—
—
—
0
0
45
401
1.15
0.32
5.2
4.7
22.51
21.55
%
0.18
29
210
7
52
1.36
0.31
1.0
1.2
—
12.00
—
0
10
7
52
1.36
0.31
1.6
1.4
—
—
—
0
0
5
39
1.29
0.23
1.0
1.2
—
—
—
0
0
213
2092
1.12
0.23
5.1
5.1
5.70
5.96
mmol/l
3.16
198
1906
27
239
1.15
0.22
1.9
2.3
4.82
9.17
umol/l
2.20
22
211
0
11
0.00
0.21
0.0
4.4
—
10.38
—
0
11
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
11
0.00
0.21
0.0
2.0
—
129.91
—
0
11
0
11
0.00
0.21
0.0
4.4
—
4.61
—
0
11
34
307
1.12
0.21
4.1
3.2
0.69
0.78
ug/l
0.52
28
207
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.26
0.20
1.3
1.2
1.21
0.92
nmol/l
—
6
37
0
14
0.00
0.20
0.0
1.4
—
53.94
—
0
14
0
14
0.00
0.20
0.0
1.6
—
45.99
—
0
14
206
2025
1.10
0.19
6.6
6.4
38.35
39.36
mmol/mol
1.15
194
1886
43
399
1.09
0.17
4.6
3.5
113.11
500.20
ng/l
1.38
33
315
78
748
1.06
0.14
4.0
4.2
25.17
7.65
mg/mmol
0.52
53
457
214
2163
0.93
0.12
5.9
5.8
2.62
2.71
mmol/l
0.83
202
1987
214
2119
1.07
0.10
5.1
5.0
1.56
1.52
mmol/l
0.49
201
1942
7
83
0.84
0.07
1.0
2.1
3.69
2.33
mg/l
—
7
63
213
2132
0.99
0.00
5.3
5.1
4.59
4.66
mmol/l
0.54
199
1964
25
251
1.00
0.00
3.0
4.8
2.54
25.08
ug/l
0.74
20
207
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
7
75
0.93
-0.00
1.7
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
24.30
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
9.69
—
0
5
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
9
0.00
-0.00
0.0
1.0
—
116.00
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
112.43
—
0
7
0
9
0.00
-0.00
0.0
1.6
—
101.89
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint M13_ATLOAXSUBLUX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ATLOAXSUBLUX | 2.573 [2.2, 3.01] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 298 out of 797 females with M13_ATLOAXSUBLUX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ATLOAXSUBLUX | 1.478 [1.18, 1.85] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 500 males with M13_ATLOAXSUBLUX died.
Mortality risk
Mortality risk for people of age
years, who have M13_ATLOAXSUBLUX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.239% |
| 5 | 1.353% | 1.353% |
| 10 | 3.347% | 3.58% |
| 15 | 6.752% | 6.956% |
| 20 | 11.712% | 11.871% |
Relationships between endpoints
↥Index endpoint: M13_ATLOAXSUBLUX – Atlantoaxial subluxation
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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