Pityriasis lichenoides chronica

L12_PARAPSO_PITYLICHCHRON

parapsoriasis: one of a group of skin disorders that are characterized primarily by their resemblance to psoriasis (red, scaly lesions), rather than by their underlying etiology. Neoplasms can develop from parapsoriasis. For example, it can develop into cutaneous T-cell lymphoma.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L41.1
  • Hospital discharge: ICD-9 6962B
  • Cause of death: ICD-10 L41.1
  • Cause of death: ICD-9 6962B

2 out of 7 registries used, show all original rules.

165

4. Check minimum number of events

None

165

5. Include endpoints

None

165

6. Filter based on genotype QC (FinnGen only)

144

Control definitions (FinnGen only)

Control exclude
L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L41
Name in latin
Pityriasis lichenoides chronica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1094 573 516
Only index persons 1012 541 471
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 47.37 51.09 43.22
Only index persons 46.68 50.15 42.71

-FinnGen-

Key figures

All Female Male
Number of individuals 144 76 68
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 56.06 53.99 58.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
149
Matched controls
1490
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L41.1
ICD-10 Finland
Pityriasis lichenoides chronica
+∞
201.6
144
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
17.9
67.9
71
72
L30.9
ICD-10 Finland
Dermatitis, unspecified
8.5
39.2
80
178
D07AC01
ATC
betamethasone; topical
7.2
31.9
98
314
E0000UV, ,
ATC
7.2
28.8
110
419
D07AD01
ATC
clobetasol; topical
6.6
25.3
53
115
D07AB02
ATC
hydrocortisone butyrate; topical
5.4
23.7
84
288
D07AB08
ATC
desonide; topical
6.4
22.4
46
97
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
242.5
21.1
21
*
D07AC13
ATC
mometasone; topical
4.7
19.4
72
248
D02AE01
ATC
carbamide; topical
8.0
16.2
24
35
L40.0
ICD-10 Finland
Psoriasis vulgaris
63.4
15.1
17
*
E000002, ,
ATC
4.9
13.2
34
85
E000001, ,
ATC
3.9
12.9
52
182
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.9
12.9
33
82
L41.4
ICD-10 Finland
Large plaque parapsoriasis
+∞
12.7
12
*
D07XC01
ATC
betamethasone; topical
4.8
11.6
30
75
L43.8
ICD-10 Finland
Other lichen planus
118.0
10.6
11
*
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.9
9.9
19
36
XQ848
NOMESCO Finland
Dermatological photography
11.8
9.6
17
16
L41.0
ICD-10 Finland
Pityriasis lichenoides et varioliformis acuta
+∞
9.5
9
*
D07AA02
ATC
hydrocortisone; topical
3.4
8.2
35
124
E000007, ,
ATC
4.7
7.0
17
40
D05AX52
ATC
calcipotriol, combinations; topical
10.0
6.9
13
14
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.1
6.9
33
125
D02AX
ATC
Other emollients and protectives
8.5
6.8
14
18
D05AX02
ATC
calcipotriol; topical
23.8
6.8
9
*
D09AB01
ATC
zinc bandage without supplements; topical
13.1
6.7
11
9
TQW80
NOMESCO Finland
Local dermatologic skincare
10.8
6.7
12
12
H02AB06
ATC
prednisolone; systemic
2.3
6.0
83
522

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
46
14.02
42.97
1.8
1.1
—
—
—
0
0
74
442
2.34
6.06
8.8
6.0
—
—
—
0
0
97
707
2.07
4.24
8.3
6.7
0.21
0.19
e9/l
0.60
89
618
96
700
2.04
4.16
8.4
6.6
1.96
1.81
e9/l
1.03
89
621
93
682
1.97
3.83
8.0
6.5
0.59
0.58
e9/l
0.27
86
591
93
687
1.94
3.69
8.2
6.5
0.04
0.04
e9/l
1.06
86
591
44
254
2.04
3.59
1.4
1.3
30.15
29.16
iu/ml
0.02
12
86
66
446
1.86
3.36
4.4
3.2
7.04
8.11
mmol/l
1.30
56
376
40
232
1.99
3.19
1.3
1.3
2.34
11.81
u/ml
1.24
12
84
62
428
1.77
2.83
3.9
3.9
3.80
7.64
mg/mmol
1.12
35
266
39
233
1.91
2.83
4.9
3.6
171.00
244.67
ng/l
0.16
25
182
96
754
1.77
2.76
11.8
10.4
4.00
4.15
e9/l
0.33
88
663
6
11
5.63
2.57
1.3
1.1
—
—
—
0
0
32
187
1.91
2.47
1.6
2.4
—
—
—
0
0
76
573
1.67
2.43
5.0
5.4
35.32
35.58
g/l
0.16
68
551
12
46
2.75
2.42
1.4
2.0
0.26
0.23
g/l
0.55
12
46
12
46
2.75
2.42
1.4
2.0
1.20
1.17
g/l
0.26
12
46
52
361
1.68
2.24
2.8
3.2
335.21
339.99
umol/l
0.13
47
315
32
198
1.78
2.06
1.6
1.4
640.00
490.83
titre
—
7
48
9
32
2.93
2.04
3.2
1.6
—
—
—
0
0
61
454
1.58
1.95
3.8
3.5
2.34
2.35
mmol/l
0.64
56
417
57
418
1.59
1.93
3.4
3.3
24.29
48.69
mg/l
1.31
37
271
67
517
1.54
1.79
2.6
2.1
—
—
—
0
0
6
18
3.43
1.76
1.5
1.1
—
—
—
0
0
6
18
3.43
1.76
7.0
2.3
5.03
4.22
e9/l
—
6
18
55
409
1.55
1.73
3.8
4.2
7.40
7.39
ph
0.65
38
295
46
329
1.58
1.71
1.5
1.4
1.74
2.19
u/ml
0.15
18
88
21
122
1.84
1.65
1.4
1.4
—
—
—
0
0
114
1000
1.60
1.61
8.2
8.3
77.69
80.24
u/l
0.28
109
940
18
100
1.91
1.61
7.6
6.1
0.43
0.70
%
—
7
32
111
969
1.57
1.59
5.5
4.5
15.16
14.83
pmol/l
0.66
103
879
17
93
1.93
1.59
2.0
3.4
—
—
—
0
0
66
520
1.48
1.55
2.3
2.0
1.40
1.33
mmol/l
0.20
58
432
11
51
2.25
1.55
1.1
1.4
417.62
257.08
miu/ml
—
6
26
21
125
1.79
1.53
1.6
1.8
—
—
—
0
0
74
599
1.47
1.50
11.6
11.8
0.00
0.00
e9/l
0.79
63
488
41
295
1.54
1.47
1.7
1.5
2.22
2.52
g/l
0.52
29
183
10
46
2.26
1.43
1.4
1.2
—
1.74
—
0
7
5
18
2.84
1.29
1.0
1.2
—
—
—
0
0
99
862
1.44
1.28
4.6
4.9
—
191.78
—
0
23
25
165
1.62
1.28
1.2
1.3
—
—
—
0
0
17
102
1.75
1.22
1.4
1.5
—
—
—
0
0
52
407
1.43
1.21
6.2
6.3
—
—
—
0
0
18
111
1.71
1.18
9.2
6.1
0.57
0.99
%
—
7
40
5
20
2.55
1.16
1.0
1.2
—
—
—
0
0
10
51
2.03
1.14
1.4
1.4
—
—
—
0
0
8
40
2.06
1.14
1.5
1.3
—
—
—
0
0
7
31
2.32
1.12
1.6
1.3
1803.57
5766.11
e6/l
—
7
19
39
294
1.44
1.10
5.2
4.3
1.02
1.02
kg/l
0.35
28
198
44
340
1.42
1.09
2.4
2.5
2.32
2.99
mg/l
1.35
39
296
41
313
1.43
1.08
5.7
5.0
—
—
—
0
0
26
181
1.53
1.08
1.5
2.6
59.56
132.87
ug/g
1.52
19
138
5
22
2.32
1.04
1.0
1.1
7.31
2.10
u/ml
—
5
14
5
22
2.32
1.04
1.0
1.0
—
—
—
0
0
10
54
1.91
0.99
1.4
1.4
—
—
—
0
0
40
309
1.40
0.99
1.9
2.1
1.14
1.60
mg/l
0.46
31
248
5
23
2.21
0.99
1.0
1.6
0.13
0.32
nmol/l
—
5
17
5
23
2.21
0.99
1.2
1.0
—
—
—
0
0
115
1050
1.42
0.99
27.2
21.2
13.59
13.68
%
0.32
115
1041
22
152
1.52
0.95
1.1
1.3
—
—
—
0
0
10
55
1.88
0.94
1.4
1.3
—
—
—
0
0
10
55
1.88
0.94
1.4
1.3
—
—
—
0
0
10
55
1.88
0.94
1.4
1.3
—
—
—
0
0
6
29
2.11
0.90
1.2
1.9
—
—
—
0
0
16
104
1.60
0.89
10.6
6.8
0.80
0.03
%
—
5
30
6
31
1.97
0.85
7.2
2.0
58.00
58.69
%
—
6
31
133
1257
1.54
0.85
18.5
17.2
20.98
23.52
mg/l
0.45
112
1023
22
156
1.48
0.85
1.4
1.6
—
—
—
0
0
77
671
1.31
0.85
6.5
8.3
1.22
1.21
mmol/l
0.52
69
576
28
211
1.40
0.80
2.0
2.4
28.78
29.17
s
0.19
28
206
0
27
0.00
0.78
0.0
1.7
—
7.51
—
0
27
34
267
1.35
0.76
1.8
1.8
617.44
453.05
pmol/l
0.94
29
226
49
407
1.30
0.75
2.5
3.4
—
—
—
0
0
61
525
1.27
0.71
5.1
4.2
0.00
0.02
estimate
0.50
16
125
111
1182
0.76
0.69
4.3
4.4
1.29
1.26
mmol/l
0.15
98
1085
7
42
1.70
0.69
1.6
1.3
—
—
—
0
0
47
393
1.29
0.68
4.6
3.6
0.00
0.00
estimate
-0.00
15
122
124
1170
1.36
0.66
6.9
5.4
1.90
1.95
mu/l
0.20
115
1069
138
1327
1.54
0.64
24.3
21.8
73.68
77.65
umol/l
1.58
138
1312
32
256
1.32
0.64
1.9
1.8
—
—
—
0
0
9
140
0.62
0.64
5.8
4.8
4.69
4.34
kpa
—
9
134
8
51
1.60
0.61
1.9
1.4
—
—
—
0
0
0
22
0.00
0.60
0.0
3.3
—
106.32
—
0
22
0
22
0.00
0.60
0.0
3.3
—
1.19
—
0
22
0
22
0.00
0.60
0.0
3.3
—
4.05
—
0
22
5
87
0.56
0.58
7.0
4.4
1.22
0.61
%
—
5
87
19
142
1.39
0.58
2.5
2.2
302.37
394.77
nmol/l
1.29
19
133
35
288
1.28
0.57
2.7
3.1
509.32
526.59
mosm/kgh2o
0.18
28
254
20
152
1.36
0.55
1.9
1.8
—
—
—
0
0
9
131
0.67
0.54
6.3
9.5
—
—
—
0
0
28
227
1.29
0.51
1.5
1.7
1338.69
1219.72
nmol/l
0.33
18
173
69
620
1.21
0.51
13.4
14.8
1.24
1.26
inr
0.08
57
503
25
200
1.30
0.51
3.1
6.0
1.04
1.05
mmol/l
0.06
19
184
64
573
1.20
0.49
2.2
2.1
94.33
95.57
pmol/l
0.07
35
286
24
194
1.28
0.45
3.6
8.1
102.79
103.80
mmol/l
0.40
24
194
5
31
1.63
0.43
1.0
1.2
—
—
—
0
0
21
168
1.29
0.43
1.3
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
3.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.1
—
3.14
—
0
18
13
98
1.36
0.39
6.5
3.7
—
—
—
0
0
75
692
1.17
0.39
4.9
4.1
0.00
0.00
estimate
-0.00
16
149
12
156
0.75
0.36
4.9
5.1
5.29
5.71
kpa
0.76
12
150
5
80
0.61
0.36
1.6
1.3
—
—
—
0
0
43
381
1.18
0.36
5.9
4.3
0.00
0.01
estimate
0.50
15
142
38
334
1.18
0.35
2.6
2.8
2.31
5.26
e6/l
3.43
31
308
67
617
1.16
0.35
3.3
3.0
—
—
estimate
—
0
0
76
707
1.15
0.34
4.9
4.2
0.18
0.00
estimate
0.48
17
140
6
86
0.69
0.34
4.0
9.3
—
—
—
0
0
6
46
1.32
0.33
4.7
4.8
83.90
188.12
mg/l
—
6
41
6
46
1.32
0.33
4.7
4.8
29.62
25.24
mg/l
—
6
41
75
701
1.14
0.30
4.9
4.1
0.00
10.68
estimate
0.50
16
152
7
55
1.29
0.30
1.3
12.9
1.40
1.44
%
—
7
49
8
109
0.72
0.30
1.3
1.3
—
—
—
0
0
9
75
1.21
0.25
1.0
1.2
—
—
—
0
0
48
441
1.13
0.25
5.0
2.6
—
—
—
0
0
17
143
1.21
0.24
2.0
1.5
—
—
—
0
0
19
162
1.20
0.24
1.5
1.5
—
—
—
0
0
58
540
1.12
0.24
4.0
4.3
18.51
46.31
ng/l
2.70
36
399
7
93
0.74
0.23
5.6
3.8
—
—
—
0
0
5
39
1.29
0.23
14.4
11.9
—
—
—
0
0
14
116
1.23
0.23
1.1
1.1
—
—
—
0
0
25
221
1.16
0.22
1.8
2.3
2.37
2.35
g/l
0.08
25
199
25
221
1.16
0.22
4.2
3.1
2.31
1.74
e6/l
0.24
16
116
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
195.39
—
0
10
0
10
0.00
0.21
0.0
1.5
—
12.00
—
0
10
0
13
0.00
0.21
0.0
13.2
—
10.16
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
25
222
1.15
0.21
1.6
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
5.1
—
—
—
0
0
6
49
1.23
0.20
1.3
13.8
0.85
0.86
%
—
6
43
45
484
0.90
0.20
3.0
3.3
—
—
—
0
0
6
51
1.18
0.19
1.5
2.2
—
—
—
0
0
139
1369
1.23
0.18
31.0
25.4
91.06
90.72
fl
0.40
139
1358
120
1172
1.12
0.18
7.8
6.7
40.33
39.74
mmol/mol
0.33
115
1099
7
62
1.14
0.17
3.3
2.1
—
—
—
0
0
139
1370
1.22
0.17
31.0
26.0
40.46
40.33
%
0.16
139
1359
139
1370
1.22
0.17
30.9
25.3
30.26
30.24
pg
0.04
139
1358
139
1370
1.22
0.17
31.2
25.6
134.15
135.11
g/l
0.35
139
1359
42
391
1.10
0.17
1.7
1.7
23.27
20.08
nmol/l
0.51
36
315
5
70
0.70
0.17
1.4
1.1
—
—
—
0
0
18
161
1.13
0.13
3.6
3.5
1.59
1.83
%
0.38
18
145
45
425
1.08
0.13
5.1
5.5
1.45
2.09
ug/l
1.49
40
382
128
1260
1.11
0.12
6.1
5.8
2.58
2.66
mmol/l
0.44
118
1168
122
1238
0.92
0.10
5.1
5.1
1.50
1.45
mmol/l
0.47
109
1141
123
1247
0.92
0.09
5.3
5.2
4.49
4.56
mmol/l
0.29
113
1159
37
389
0.94
0.09
1.1
1.4
—
—
—
0
0
11
97
1.14
0.09
5.4
8.9
25.45
24.79
mmol/l
0.31
11
97
6
53
1.14
0.09
1.0
1.1
—
—
—
0
0
5
60
0.83
0.08
1.6
1.6
—
—
—
0
0
15
137
1.11
0.08
2.1
4.6
549.52
55.46
ug/l
—
9
119
129
1304
0.92
0.08
19.6
14.8
—
—
—
0
0
37
386
0.94
0.07
3.1
3.1
—
0.00
—
0
9
52
534
0.96
0.05
4.8
4.0
418.71
49.82
e6/l
0.44
39
396
42
407
1.04
0.05
4.0
3.2
0.47
0.36
e6/l
0.13
32
310
49
477
1.04
0.05
4.0
3.4
39.08
165.98
e6/l
0.47
39
379
12
130
0.92
0.05
1.9
1.7
—
—
—
0
0
57
558
1.03
0.04
4.1
3.8
6.00
6.25
ph
1.14
33
317
13
139
0.93
0.03
1.9
1.4
—
—
—
0
0
38
390
0.97
0.03
4.1
4.7
—
—
—
0
0
17
162
1.06
0.02
2.4
10.8
7.40
7.41
ph
—
7
99
13
137
0.94
0.01
3.2
2.9
34.38
29.96
u/l
0.27
13
107
25
243
1.03
0.01
2.7
3.1
0.51
0.82
ug/l
1.92
15
154
21
207
1.02
0.00
1.9
2.3
23.48
22.40
%
0.11
21
192
44
443
0.99
0.00
3.5
4.0
—
—
—
0
0
122
1218
1.01
0.00
5.7
5.2
5.99
5.98
mmol/l
0.02
111
1121
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
58.75
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
33.50
—
0
5
0
5
0.00
-0.00
0.0
4.0
—
1.36
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
69.86
—
0
7
6
59
1.02
-0.00
3.3
2.1
1.40
1.54
g/l
—
6
53
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
0.00
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
123.21
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
74
0.94
-0.00
3.4
4.2
37.07
36.85
°c
—
7
74
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
68
0.88
-0.00
3.8
4.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_PARAPSO_PITYLICHCHRON and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
L12_PARAPSO_PITYLICHCHRON 1.103 [0.81, 1.5] 0.535
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 434 males with L12_PARAPSO_PITYLICHCHRON died.

Mortality risk

Mortality risk for people of age

years, who have L12_PARAPSO_PITYLICHCHRON.

N-year risk Females Males
1 No data 0.262%
5 No data 1.381%
10 No data 3.296%
15 No data 5.941%
20 No data 10.029%

Relationships between endpoints

Index endpoint: L12_PARAPSO_PITYLICHCHRON – Pityriasis lichenoides chronica

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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