phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.
Other and unspecified skin changes due to chronic exposure to nonionizing radiation
DOID EFO Endpoint Browser PheWeb
L12_NONIONRADISKINNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
533 |
4. Check minimum number of eventsNone |
533 |
5. Include endpointsNone |
533 |
6. Filter based on genotype QC (FinnGen only) |
485 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified skin changes due to chronic exposure to nonionizing radiation
based on the number of shared cases.
Similar with more cases:
- Skin changes due to chronic exposure to nonionizing radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3420 | 1992 | 1406 |
| Only index persons | 3066 | 1831 | 1235 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 71.86 | 71.91 | 71.77 |
| Only index persons | 71.03 | 71.15 | 70.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 485 | 250 | 235 |
| Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.11 |
| Median age at first event (years) | 68.99 | 67.50 | 70.57 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 499
- Matched controls
- 4990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
+∞
307.7
311
*
L57.0
ICD-10 Finland
Actinic keratosis
62.1
307.7
322
142
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
23.0
264.5
239
192
ZXC50
NOMESCO Finland
Cryotherapy
85.1
245.9
132
21
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
117.3
228.5
117
13
L57.9
ICD-10 Finland
Skin changes due to chronic exposure to nonionizing radiation, unspecified
3592.5
225.9
201
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
52.1
182.0
107
26
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
9.3
111.8
167
256
ZXC15
NOMESCO Finland
Use of photodynamic technique
53.3
105.5
61
13
TQW99
NOMESCO Finland
Other minor procedure on skin
14.7
104.5
102
86
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
32.6
103.0
68
24
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
9.0
94.1
137
201
D06BB10
ATC
imiquimod; topical
13.3
89.1
91
82
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
23.2
86.9
65
32
XQ845
NOMESCO Finland
Dermatoscopy
35.5
84.4
54
17
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
26.6
83.6
59
25
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
8.7
80.8
118
172
XQ848
NOMESCO Finland
Dermatological photography
19.2
75.0
61
36
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
117.0
74.4
79
8
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
30.1
72.8
49
18
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
13.0
59.6
60
52
R23.8
ICD-10 Finland
Other and unspecified skin changes
4.3
51.7
190
625
TEA00
NOMESCO Finland
Biopsy of lip
21.1
50.7
39
20
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
18.0
48.4
40
24
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
8.2
45.6
65
90
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
5.8
36.6
73
143
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.6
34.6
149
529
ZXC20
NOMESCO Finland
Use of chemical agents
11.3
34.4
37
35
ZZR00
NOMESCO Finland
Flap of skin
9.0
31.3
40
48
E0000UV, ,
ATC
2.9
31.0
270
1425
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
11.0
30.1
33
32
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
9.5
27.1
33
37
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
8.1
26.7
37
49
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
+∞
26.3
25
*
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
76.6
26.1
29
*
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
47.0
25.8
31
7
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
24.6
198
975
L82
ICD-10 Finland
Seborrhoeic keratosis
3.0
24.6
146
613
D07AC01
ATC
betamethasone; topical
2.5
22.6
231
1266
E000001, ,
ATC
2.9
22.6
129
528
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
37.0
22.3
28
8
D07AB08
ATC
desonide; topical
3.4
21.6
87
289
SPAT1153
SPAT
Removal of sutures
2.5
21.5
216
1169
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
6.9
20.7
33
51
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
3.7
20.3
69
205
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
37.5
20.0
25
7
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
17.6
19.4
30
18
EAA10
NOMESCO Finland
Excision of lesion of lip
15.9
18.7
30
20
D07AA02
ATC
hydrocortisone; topical
3.0
18.7
93
350
TQW80
NOMESCO Finland
Local dermatologic skincare
7.8
18.4
26
35
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
20.3
18.4
27
14
ZXC07
NOMESCO Finland
Carbon dioxide laser
+∞
17.8
17
*
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
98.6
17.7
19
*
S18
ICPC
Laceration/cut
2.3
17.7
285
1846
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
5.9
17.5
32
57
WXQ41
NOMESCO Finland
Photodynamic therapy of head and neck
+∞
16.8
16
*
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
93.2
16.7
18
*
D04.8
ICD-10 Finland
Carcinoma in situ: Skin of other sites
175.6
16.6
17
*
D07AC13
ATC
mometasone; topical
2.3
16.3
171
921
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
62.1
15.9
18
*
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
62.1
15.9
18
*
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
39.4
15.5
19
5
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.8
14.9
86
349
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
26.0
14.8
20
8
D06BX02
ATC
ingenol mebutate; topical
14.8
14.7
24
17
K13.03
ICD-10 Finland
Keilit UNS
37.3
14.5
18
5
P01BA02
ATC
hydroxychloroquine; oral
3.2
14.5
63
218
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
28.1
14.4
19
7
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
23.1
14.3
20
9
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.5
14.3
52
161
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.1
13.8
39
101
E000002, ,
ATC
3.0
13.4
66
245
EAA30
NOMESCO Finland
Partial excision of lower lip
41.3
13.2
16
*
S21
ICPC
Skin texture symptom/complaint
2.5
13.1
98
450
D02AX
ATC
Other emollients and protectives
5.3
12.8
26
51
S08
ICPC
Skin colour change
3.5
12.8
46
141
ZXC10
NOMESCO Finland
Use of laser
5.7
12.7
24
44
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
33.0
12.6
16
5
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
33.0
12.6
16
5
L01BC02
ATC
fluorouracil; systemic, topical
33.0
12.6
16
5
ZZA00
NOMESCO Finland
Split skin graft
4.5
12.6
31
72
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.2
12.5
143
785
L56.4
ICD-10 Finland
Polymorphous light eruption
38.6
12.3
15
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.0
12.2
58
211
WX723
NOMESCO Finland
CPAP therapy
4.4
12.2
31
74
E000007, ,
ATC
4.0
11.9
35
93
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
47.9
11.9
14
*
S29
ICPC
Skin symptom/complaint other
2.2
11.8
120
626
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.1
11.8
53
186
D05BB02
ATC
acitretin; oral
5.7
11.7
22
40
L43.9
ICD-10 Finland
Lichen planus, unspecified
5.4
11.6
23
44
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.2
11.4
47
157
-54
ICPC
Repair/fix-suture/cast/prosth device
5.7
11.3
21
38
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
13.1
11.2
19
15
WX780
NOMESCO Finland
Remote monitoring CPAP
4.1
11.2
31
79
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
28.7
10.8
14
5
D07AD01
ATC
clobetasol; topical
2.3
10.8
97
481
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
22.0
10.7
15
7
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
61.3
10.7
12
*
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
12.4
10.4
18
15
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
10.4
253
1777
8090/3-C44.4
ICD-O-3
Basal cell carcinoma, NOS, of skin of scalp and neck
10.9
10.4
19
18
TQW40, ,
SPAT
2.6
10.3
66
280
DHB00
NOMESCO Finland
Excision of lesion of external nose
13.5
10.2
17
13
L30.8
ICD-10 Finland
Other specified dermatitis
4.4
10.2
26
62
WX110
NOMESCO Finland
Infiltration anesthesia
1.9
10.1
327
2504
A02BC05
ATC
esomeprazole; systemic
1.8
10.0
222
1509
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
9.9
104
547
ZQZ00
NOMESCO Finland
Treatment of several skin areas
20.5
9.8
14
7
SPAT1141
SPAT
Excision of skin or mucous membrane lesion
3.4
9.8
36
112
8070/3-C00.1
ICD-O-3
Squamous cell carcinoma, NOS, of external lower lip
56.1
9.7
11
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
9.5
226
1565
E000003, ,
ATC
3.7
9.4
30
85
S77
ICPC
Malignant neoplasm of skin
8.9
9.4
19
22
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
9.3
368
2964
D04.9
ICD-10 Finland
Carcinoma in situ: Skin, unspecified
14.0
9.2
15
11
L56.9
ICD-10 Finland
Acute skin change due to ultraviolet radiation, unspecified
37.4
9.0
11
*
B07.9
ICD-10 Finland
Verruca simplex
4.1
9.0
25
64
8090/3-C44.6
ICD-O-3
Basal cell carcinoma, NOS, of skin of upper limb and shoulder
19.0
9.0
13
7
C44.3
ICD-10 Finland
Malignant neoplasm: Skin of other and unspecified parts of face
24.5
8.9
12
5
127
Kela drug reimbursment
Transplant complication
12.8
8.9
15
12
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
9.7
8.8
17
18
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
3.5
8.8
30
89
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
4.4
8.7
22
52
J01DB01
ATC
cefalexin; oral
2.0
8.7
401
3353
8070/3-C44.2
ICD-O-3
Squamous cell carcinoma, NOS, of external ear
28.1
8.5
11
*
QCA50
NOMESCO Finland
Cryotherapy of skin of upper limb
+∞
8.4
8
*
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
3.8
8.3
25
68
H02AB06
ATC
prednisolone; systemic
1.7
8.2
257
1900
CBB30
NOMESCO Finland
Excision of lesion of eyelid
3.9
8.2
24
64
SPAT1263
SPAT
Sampling
1.7
8.1
216
1526
L04AA01
ATC
[U] ciclosporin
10.3
8.1
15
15
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
22.4
8.0
11
5
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
8.0
122
729
SPAT1312
SPAT
General health counselling
1.8
8.0
156
1007
D06AX01
ATC
fusidic acid; topical
2.4
7.9
55
242
QAA99
NOMESCO Finland
Other local destruction of skin of head or neck
13.3
7.9
13
10
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
7.8
67
324
J01CA04
ATC
amoxicillin; systemic
1.8
7.8
381
3173
DAB00
NOMESCO Finland
Excision of lesion of auricle
8.2
7.6
16
20
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
18.7
7.6
11
6
C08CA01
ATC
amlodipine; oral
1.7
7.5
241
1779
L30.3
ICD-10 Finland
Infective dermatitis
3.5
7.5
26
78
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.5
174
1178
L04AD01
ATC
ciclosporin; systemic
7.8
7.4
16
21
K13.09
ICD-10 Finland
Disease of the lips UNS
81.3
7.4
8
*
M79.6
ICD-10 Finland
Pain in limb
1.7
7.4
218
1572
DAB10
NOMESCO Finland
Partial excision of auricle
16.0
7.3
11
7
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.2
273
2095
C44.50
ICD-10 Finland
Malignant tumor of the skin on the torso without histology
30.5
7.2
9
*
C07AB07
ATC
bisoprolol; oral
1.7
7.2
300
2363
J05AB01
ATC
aciclovir; systemic
1.8
7.1
117
713
H53.1
ICD-10 Finland
Subjective visual disturbances
2.6
7.1
40
159
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
3.3
7.1
27
86
L20.0
ICD-10 Finland
Besnier prurigo
3.3
7.1
27
86
L04AX01
ATC
azathioprine; systemic
3.3
7.1
26
81
L04AX03
ATC
methotrexate; systemic
2.4
7.0
51
229
J02AC01
ATC
fluconazole; systemic
1.7
7.0
167
1135
ZXE00
NOMESCO Finland
One hour or less
1.7
6.9
196
1391
UKC02
NOMESCO Finland
Cystoscopy
1.8
6.9
110
663
UDC00
NOMESCO Finland
Ear microscopy
2.4
6.9
49
218
SPAT1325
SPAT
Vaccination
1.7
6.7
196
1400
R4110, ,
SPAT
2.0
6.7
78
424
XQ802
NOMESCO Finland
Epicutan test
3.4
6.6
23
69
A02BC02
ATC
pantoprazole; systemic
1.7
6.6
347
2868
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
6.6
69
360
SPAT1301
SPAT
No procedures
1.7
6.5
173
1204
SPAT1260
SPAT
Consultation of another employee
1.9
6.5
98
581
M54.5
ICD-10 Finland
Low back pain
1.7
6.5
172
1198
WX704
NOMESCO Finland
Intubation
2.4
6.4
43
186
8070/3-C44.6
ICD-O-3
Squamous cell carcinoma, NOS, of skin of upper limb and shoulder
70.7
6.4
7
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.7
6.4
35
137
A98
ICPC
Health maint/preventive medicine
2.2
6.4
450
4035
C08CA02
ATC
felodipine; oral
2.0
6.4
70
372
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.3
6.4
24
76
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.8
6.3
118
746
8070/3-C44.5
ICD-O-3
Squamous cell carcinoma, NOS, of skin of trunk
27.0
6.2
8
*
8090/3-C44.0
ICD-O-3
Basal cell carcinoma, NOS, of skin of lip, NOS
27.0
6.2
8
*
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.2
214
1587
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.0
6.2
75
413
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
6.1
52
250
S04
ICPC
Lump/swelling localized
2.1
6.1
56
278
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.7
6.1
153
1047
D07XC01
ATC
betamethasone; topical
2.0
6.1
65
342
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
10.2
6.1
11
11
N02BE01
ATC
paracetamol; systemic, rectal
2.0
6.0
442
3955
Z01.2
ICD-10 Finland
Dental examination
1.6
6.0
189
1367
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
103
482
2.43
13.21
5.3
3.9
—
—
—
0
0
192
1186
2.01
12.13
4.9
3.9
0.00
0.12
estimate
0.94
74
368
308
2262
1.94
11.44
4.9
4.4
0.00
7.14
estimate
0.80
96
491
388
3094
2.14
11.34
5.8
4.6
16.49
14.75
mm/h
1.12
361
2847
304
2238
1.92
11.03
4.9
4.4
0.00
0.00
estimate
-0.00
89
472
42
136
3.28
10.71
1.8
1.4
—
—
—
0
0
306
2282
1.88
10.40
5.0
4.4
0.00
0.66
estimate
0.51
89
460
400
3283
2.10
9.99
10.8
8.4
79.03
81.44
u/l
0.69
385
3094
195
1287
1.85
9.59
5.2
4.4
0.00
0.00
estimate
0.50
87
421
377
3053
1.96
9.45
4.9
4.3
15.14
15.11
pmol/l
0.10
338
2724
344
2715
1.86
9.20
5.9
5.1
6.89
6.82
mmol/l
0.17
325
2592
312
2394
1.81
9.11
10.1
9.4
4.09
4.31
e9/l
1.16
278
2087
448
3896
2.47
8.91
26.3
19.8
24.14
27.05
mg/l
1.13
390
3332
309
2381
1.78
8.72
22.1
18.0
1.32
1.34
inr
0.31
274
1992
235
1676
1.76
8.68
5.1
4.5
0.04
0.06
estimate
0.17
76
394
286
2162
1.76
8.56
6.5
4.9
34.91
34.67
g/l
0.31
265
2024
206
1439
1.73
8.01
2.7
2.5
56.65
63.28
u/l
0.74
189
1333
457
4060
2.49
7.77
30.8
24.1
139.35
139.61
mmol/l
1.20
451
3972
457
4063
2.48
7.70
31.5
24.3
4.00
4.01
mmol/l
0.29
449
3971
218
1592
1.66
6.91
2.3
1.9
1.24
1.26
mmol/l
0.11
167
1299
302
2397
1.66
6.87
3.5
3.3
52.74
54.50
u/l
0.12
285
2207
459
4131
2.39
6.77
39.1
29.7
241.66
241.25
e9/l
0.04
448
4040
459
4131
2.39
6.77
39.0
29.7
4.35
4.36
e12/l
0.20
446
4022
164
1117
1.70
6.75
3.7
2.8
4.06
5.27
e6/l
1.29
152
1024
419
3654
1.91
6.64
6.2
5.5
2.00
2.01
mu/l
0.06
383
3295
75
404
2.01
6.58
2.2
1.9
386.52
396.36
nmol/l
0.15
69
368
424
3720
1.93
6.48
8.5
7.3
40.33
40.40
mmol/mol
0.05
393
3429
434
3850
1.98
6.23
7.2
6.3
2.45
2.52
mmol/l
1.07
394
3489
22
67
3.39
6.21
1.5
2.4
31.64
32.10
pg
0.20
22
67
280
2229
1.58
5.90
7.6
6.2
1.20
1.21
mmol/l
0.70
255
2028
71
390
1.96
5.89
5.6
4.1
1.23
1.22
mmol/l
0.07
57
342
101
624
1.78
5.79
1.3
1.3
27.57
14.97
u/ml
0.40
40
220
24
82
3.02
5.65
2.5
1.6
—
—
—
0
0
302
2466
1.57
5.55
9.7
7.0
1.21
1.21
mmol/l
0.73
243
2116
447
4044
2.01
5.49
17.6
13.0
24.06
23.72
u/l
0.20
431
3892
31
125
2.58
5.40
2.1
1.5
—
—
—
0
0
421
3743
1.80
5.38
6.2
5.3
1.46
1.47
mmol/l
0.30
382
3376
37
164
2.36
5.28
1.9
1.6
6.74
9.55
iu/ml
—
10
47
423
3772
1.80
5.27
6.5
5.4
4.34
4.44
mmol/l
1.26
387
3427
294
2406
1.54
5.19
7.6
6.7
11.05
12.10
umol/l
1.50
279
2296
405
3573
1.71
5.18
5.1
4.5
1.22
1.25
mmol/l
0.38
359
3183
198
1495
1.54
5.03
2.5
2.2
147.59
278.36
u/l
1.61
182
1412
19
61
3.20
4.96
2.1
1.5
—
—
—
0
0
19
61
3.20
4.96
2.1
1.6
—
—
—
0
0
224
1741
1.52
4.95
5.4
4.2
127.67
115.42
e6/l
0.10
175
1283
222
1723
1.52
4.94
4.9
3.5
—
—
—
0
0
148
1052
1.58
4.89
1.8
1.8
441.82
6667107.43
pmol/l
0.50
117
855
241
1910
1.51
4.81
4.1
3.0
136.89
146.39
ug/l
0.33
222
1747
240
1909
1.50
4.66
5.5
4.4
50.21
57.91
ng/l
0.16
195
1530
423
3808
1.73
4.63
6.6
5.7
6.00
6.09
mmol/l
0.83
379
3426
160
1170
1.54
4.63
4.2
2.9
357.16
358.80
umol/l
0.07
144
1000
245
1962
1.49
4.57
2.9
2.4
81.56
79.80
nmol/l
0.44
220
1716
111
752
1.61
4.45
4.0
2.5
20.89
21.15
%
0.09
97
704
215
1684
1.49
4.44
4.2
3.5
2.34
2.35
mmol/l
0.79
194
1511
15
37
4.15
4.44
2.3
1.8
—
—
—
0
0
117
806
1.59
4.37
4.0
2.5
2.29
2.27
g/l
0.13
105
747
12
24
5.10
4.34
2.0
1.6
—
—
—
0
0
22
85
2.66
4.19
3.9
3.0
8.43
9.96
pmol/l
0.40
22
85
199
1552
1.47
4.13
4.3
3.3
6.89
6.94
mmol/l
0.07
167
1279
12
26
4.70
4.08
2.0
1.6
—
—
—
0
0
29
131
2.29
4.01
2.3
1.6
—
—
—
0
0
101
689
1.58
3.90
1.3
1.3
42.35
40.84
iu/ml
0.03
29
232
246
2018
1.43
3.81
3.0
3.0
—
—
estimate
—
0
0
235
1918
1.43
3.72
2.8
2.5
—
—
—
0
0
199
1578
1.43
3.68
5.2
4.1
15.56
9.03
mg/mmol
0.71
120
988
20
79
2.60
3.67
1.8
1.5
—
—
—
0
0
199
1584
1.43
3.58
4.7
3.6
87.65
105.22
e6/l
0.13
169
1250
115
826
1.51
3.51
1.4
1.3
2.31
1.12
u/ml
0.35
27
200
12
31
3.94
3.51
2.0
1.5
—
—
—
0
0
22
94
2.40
3.46
1.8
1.5
—
—
—
0
0
25
119
2.16
3.09
1.3
1.2
2.02
2.66
u/ml
—
6
24
212
1743
1.38
3.03
4.1
3.3
2059.35
1767.83
ng/l
0.35
180
1527
132
1001
1.43
3.02
6.4
4.3
460.96
314.79
ng/l
0.23
105
871
262
2231
1.37
3.00
2.3
2.3
95.60
94.48
pmol/l
0.14
139
1173
168
1332
1.39
2.98
2.4
2.4
3.18
3.08
mg/l
0.24
149
1144
35
192
1.88
2.97
2.3
4.2
60.11
85.93
mg/l
0.35
29
166
35
192
1.88
2.97
2.4
4.2
60.90
58.28
mg/l
0.03
29
168
171
1363
1.39
2.94
4.6
3.5
0.51
0.46
e6/l
0.08
138
1031
60
388
1.62
2.89
2.0
1.7
—
—
—
0
0
405
3720
1.47
2.87
26.2
19.6
69.66
72.20
ml/min/173m2
1.66
388
3491
110
815
1.45
2.84
4.1
3.0
0.80
0.82
mmol/l
0.79
101
769
116
869
1.44
2.83
4.1
2.5
12.09
12.05
umol/l
0.02
105
809
8
18
4.50
2.80
4.5
5.0
—
—
—
0
0
134
1032
1.41
2.80
1.9
1.8
1190.92
1177.21
nmol/l
0.06
104
778
23
112
2.10
2.71
1.8
1.5
—
—
—
0
0
35
199
1.82
2.68
4.2
3.3
—
—
—
0
0
14
55
2.59
2.63
1.1
1.2
—
—
—
0
0
21
100
2.15
2.62
1.9
1.4
—
—
—
0
0
34
194
1.81
2.58
2.2
1.7
—
—
—
0
0
44
271
1.68
2.57
2.9
2.2
13.61
12.99
nmol/l
0.16
33
233
65
443
1.54
2.52
1.5
1.4
—
—
—
0
0
32
181
1.82
2.50
1.8
1.6
—
—
—
0
0
13
51
2.59
2.46
1.8
1.5
—
—
—
0
0
25
131
1.96
2.45
1.3
1.4
339.62
270.68
ug/g
1.53
19
76
6
12
5.05
2.41
1.8
1.0
11.10
9.79
ug/l
—
6
12
14
58
2.45
2.39
1.8
1.7
87.04
89.25
%
0.40
14
58
26
140
1.90
2.36
2.8
2.1
136.19
125.07
g/l
1.97
21
106
92
682
1.43
2.36
11.6
4.9
1.05
1.03
mmol/l
0.25
85
622
66
459
1.50
2.34
2.5
3.4
64.88
66.36
g/l
0.73
58
420
59
401
1.53
2.33
6.3
3.6
115.28
90.37
ng/l
1.26
46
343
22
113
1.99
2.29
1.4
1.5
—
—
—
0
0
182
1515
1.32
2.25
7.6
6.1
2.62
3.04
ug/l
0.32
157
1335
5
9
5.60
2.22
1.0
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
153
1.81
2.12
2.1
2.5
0.37
0.41
iu/ml
0.16
17
86
30
177
1.74
2.07
2.3
3.9
7.91
3.17
ratio
0.33
14
103
24
133
1.85
2.03
1.5
1.3
—
—
—
0
0
15
70
2.18
2.00
2.0
1.8
54.93
48.66
nmol/l
0.42
15
64
13
57
2.31
1.99
1.6
1.2
—
—
—
0
0
115
914
1.34
1.93
2.8
2.0
—
—
—
0
0
45
301
1.54
1.93
5.9
3.7
2.10
2.08
mmol/l
0.01
34
223
58
411
1.47
1.90
3.3
2.5
0.23
0.57
e6/l
1.55
58
396
23
130
1.81
1.85
2.6
3.9
1.21
1.87
index
0.36
14
75
182
1548
1.28
1.84
1.9
1.8
19.67
20.69
nmol/l
0.43
153
1271
5
12
4.20
1.82
1.2
1.2
—
—
—
0
0
7
23
3.07
1.80
2.3
1.6
—
—
—
0
0
7
23
3.07
1.80
2.3
1.6
—
—
—
0
0
7
23
3.07
1.80
2.3
1.6
—
—
—
0
0
7
23
3.07
1.80
2.3
1.6
—
—
—
0
0
12
54
2.25
1.75
1.1
1.1
304.57
351.68
u/ml
—
7
25
6
18
3.36
1.75
1.8
1.2
—
—
—
0
0
6
18
3.36
1.75
1.8
1.2
—
—
—
0
0
8
30
2.69
1.73
1.0
1.1
—
—
—
0
0
8
30
2.69
1.73
1.7
1.3
—
—
—
0
0
8
30
2.69
1.73
1.8
1.3
—
—
—
0
0
14
68
2.09
1.71
1.2
1.4
—
—
—
0
0
22
127
1.77
1.67
1.4
1.4
—
—
—
0
0
23
136
1.72
1.61
1.7
1.7
27284.83
19361.95
e6/l
0.25
12
97
7
26
2.72
1.58
3.3
1.8
1400.43
546.71
e6/l
—
7
21
6
20
3.02
1.58
1.3
3.0
194.17
144.50
nmol/l
—
6
20
11
50
2.23
1.58
1.1
1.1
1.62
1.58
g/l
0.16
11
45
16
85
1.91
1.56
1.2
1.3
—
—
—
0
0
0
44
0.00
1.52
0.0
1.2
—
1.77
—
0
13
116
962
1.27
1.41
1.7
1.7
1.27
1.54
mg/l
0.61
87
778
61
465
1.36
1.37
1.8
2.2
0.19
0.20
g/l
0.47
55
427
119
995
1.26
1.35
4.5
4.8
1.02
1.02
kg/l
0.01
87
703
14
75
1.89
1.35
1.6
1.4
—
—
—
0
0
12
61
1.99
1.34
1.7
1.6
—
—
—
0
0
155
1337
1.23
1.33
3.2
3.1
30.37
33.99
u/l
0.66
144
1265
98
803
1.27
1.32
2.0
1.8
29.75
29.52
s
0.12
90
773
35
243
1.47
1.32
1.8
1.8
0.67
2.16
ug/l
2.10
35
212
5
18
2.79
1.29
1.4
1.8
62.90
45.60
ug/l
—
5
18
9
45
2.02
1.24
1.2
1.2
—
—
—
0
0
8
37
2.18
1.22
1.1
1.2
120.38
85.41
pmol/l
—
8
37
5
19
2.65
1.22
1.4
2.3
—
—
—
0
0
5
19
2.65
1.22
3.0
1.6
—
—
—
0
0
5
19
2.65
1.22
2.8
1.5
—
—
—
0
0
5
19
2.65
1.22
2.8
1.5
—
—
—
0
0
13
71
1.85
1.20
1.3
1.5
—
—
—
0
0
125
1067
1.23
1.18
3.3
3.1
2.46
2.47
mmol/l
0.31
115
958
36
258
1.43
1.17
1.4
1.9
1.39
1.58
g/l
0.68
28
230
43
320
1.38
1.14
1.4
1.5
—
—
—
0
0
11
58
1.92
1.13
1.4
1.4
—
—
—
0
0
12
66
1.84
1.10
5.6
4.9
10.64
13.00
mg/l
1.03
12
61
26
178
1.49
1.07
1.6
1.3
—
—
—
0
0
17
105
1.64
1.07
1.4
1.2
—
—
—
0
0
7
33
2.14
1.06
1.3
1.3
—
—
—
0
0
20
130
1.56
1.04
1.5
1.5
—
—
—
0
0
5
22
2.29
1.03
9.0
3.3
—
—
—
0
0
9
47
1.93
1.02
2.4
1.6
—
—
—
0
0
10
53
1.90
1.02
2.3
1.2
446.90
241.00
pmol/l
—
10
47
10
54
1.87
0.97
1.7
1.4
—
—
—
0
0
9
50
1.81
0.97
2.4
1.6
—
—
—
0
0
55
437
1.29
0.97
1.7
1.4
—
—
—
0
0
28
200
1.42
0.95
2.7
2.8
1.37
0.95
g/l
0.30
21
174
9
51
1.78
0.95
2.4
2.6
—
—
—
0
0
25
175
1.45
0.95
2.4
2.7
0.00
0.03
g/l
0.50
20
159
21
142
1.50
0.94
1.4
1.4
—
—
—
0
0
10
55
1.83
0.92
1.7
1.3
—
—
—
0
0
8
42
1.92
0.89
1.3
1.3
133.50
48.72
u/l
—
8
37
21
144
1.48
0.88
1.6
1.7
—
—
—
0
0
83
701
1.22
0.88
2.5
1.9
—
—
—
0
0
20
136
1.49
0.88
1.7
1.6
24.10
13.74
u/ml
—
6
19
8
44
1.83
0.86
2.1
1.6
—
—
—
0
0
8
44
1.83
0.86
2.1
1.6
—
—
—
0
0
8
44
1.83
0.86
2.1
1.6
—
—
—
0
0
12
72
1.68
0.86
2.3
2.0
11.00
10.45
mmol/l
0.21
12
72
23
163
1.43
0.83
1.0
1.0
—
—
—
0
0
27
198
1.38
0.82
1.4
1.2
129.40
132.07
u/ml
—
10
72
15
223
0.66
0.80
1.5
3.6
1157.70
1481.77
u/ml
—
10
190
0
26
0.00
0.78
0.0
3.6
—
0.73
—
0
26
75
638
1.21
0.75
5.0
6.6
0.85
1.22
mmol/l
0.39
59
526
9
55
1.65
0.74
1.8
1.3
—
—
—
0
0
42
336
1.27
0.73
3.0
2.8
49.70
57.22
ml/min/173m2
0.80
27
151
14
92
1.54
0.73
1.1
1.2
—
16.30
—
0
5
9
56
1.62
0.72
1.8
1.3
—
—
—
0
0
9
57
1.59
0.71
1.8
1.3
—
—
—
0
0
9
57
1.59
0.71
1.8
1.3
—
—
—
0
0
8
54
1.49
0.57
2.0
1.3
0.69
35.33
nmol/l
—
8
49
75
658
1.16
0.56
2.5
2.0
—
—
—
0
0
74
649
1.16
0.55
5.1
6.6
4.88
5.07
kpa
1.05
68
628
74
650
1.16
0.54
5.1
6.5
11.90
11.57
kpa
0.23
68
630
28
348
0.79
0.54
4.6
8.3
1.08
1.27
%
0.74
28
343
63
548
1.17
0.52
5.3
3.1
1.36
2.03
mmol/l
0.92
52
453
49
569
0.85
0.49
3.2
4.4
2.98
31.89
ug/l
1.37
40
488
16
119
1.36
0.48
4.0
2.6
89.89
86.02
ug/min
—
9
69
47
546
0.85
0.48
7.3
8.7
—
—
—
0
0
5
33
1.52
0.41
2.2
3.7
1.00
0.82
index
—
5
33
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
77
844
0.90
0.36
4.1
3.1
1.25
1.07
e6/l
0.23
49
462
6
43
1.40
0.35
2.8
3.1
1343.33
910.14
mg
—
6
43
21
172
1.23
0.35
2.5
2.8
0.00
0.00
g/l
-0.00
15
152
7
52
1.35
0.31
1.6
1.4
—
—
—
0
0
50
452
1.12
0.28
2.9
2.6
4.36
6.42
ug/l
0.61
45
391
8
63
1.27
0.28
1.0
1.3
298.25
280.47
u/l
—
8
58
12
95
1.27
0.26
1.4
1.4
—
—
—
0
0
8
67
1.20
0.26
5.5
4.3
—
—
—
0
0
128
1214
1.07
0.26
5.6
5.0
23.96
22.06
%
0.76
67
644
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
10.68
—
0
5
0
14
0.00
0.20
0.0
1.0
—
356.14
—
0
7
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
28
311
0.89
0.19
3.5
3.8
43.85
47.72
%
0.36
28
303
83
874
0.94
0.18
4.2
3.4
0.94
0.85
ug/l
0.16
64
616
13
110
1.19
0.17
1.6
1.7
—
—
—
0
0
16
139
1.16
0.16
1.4
1.7
—
—
—
0
0
12
140
0.85
0.15
1.2
1.2
—
—
—
0
0
49
519
0.94
0.13
2.5
2.8
9.03
9.20
umol/l
0.02
37
461
12
138
0.87
0.13
1.2
1.2
—
—
—
0
0
82
788
1.05
0.12
4.5
3.3
3.13
2.60
e6/l
0.19
52
405
21
191
1.10
0.12
2.7
2.0
352.62
535.02
ug/l
0.28
21
182
29
271
1.07
0.10
1.6
1.5
—
—
—
0
0
6
56
1.07
0.08
1.8
1.9
—
—
—
0
0
16
173
0.92
0.07
1.4
1.3
—
—
—
0
0
109
1101
0.99
0.02
2.8
2.7
—
—
—
0
0
58
571
1.02
0.02
6.2
5.4
34.61
32.68
%
0.66
46
345
10
107
0.93
0.02
1.2
1.3
—
—
—
0
0
10
107
0.93
0.02
1.2
1.3
—
—
—
0
0
10
104
0.96
0.00
2.4
1.9
8.50
13.93
mg/l
—
10
96
37
365
1.01
0.00
1.6
1.7
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
-0.00
0.0
1.1
—
115.14
—
0
7
9
90
1.00
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
59
0.85
-0.00
1.4
1.1
—
—
—
0
0
6
64
0.94
-0.00
1.8
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
8.56
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
96.20
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
44.80
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
0.60
—
0
5
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_NONIONRADISKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NONIONRADISKINNAS | 0.839 [0.75, 0.94] | 0.003 |
| Birth year | 0.995 [0.99, 1.0] | 0.298 |
During the follow-up period (1.1.1998 — 31.12.2019), 659 out of 1855 females with L12_NONIONRADISKINNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NONIONRADISKINNAS | 0.902 [0.79, 1.03] | 0.133 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 578 out of 1306 males with L12_NONIONRADISKINNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NONIONRADISKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.162% |
| 5 | 0.522% | 0.98% |
| 10 | 1.337% | 2.459% |
| 15 | 2.522% | 4.826% |
| 20 | 4.316% | 8.193% |
Relationships between endpoints
↥Index endpoint: L12_NONIONRADISKINNAS – Other and unspecified skin changes due to chronic exposure to nonionizing radiation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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