Onychogryphosis

L12_NAIL_GRYPHOSIS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L60.2 Hospital discharge: ICD-9 — 7038C Hospital discharge: ICD-8 — 70305 Cause of death: ICD-10 — L60.2 Cause of death: ICD-9 — 7038C Cause of death: ICD-8 — 70305 2 out of 7 registries used, show all original rules.	106
4. Check minimum number of events None	106
5. Include endpoints None	106
6. Filter based on genotype QC (FinnGen only)	91

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L60
Name in latin: Onychogryposis

NAME	L12_NAIL_GRYPHOSIS
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L602
HD_ICD_9	7038C
HD_ICD_8	70305
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L602
COD_ICD_9	7038C
COD_ICD_8	70305
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Onychogryphosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1009	654	347
Only index persons	760	483	277
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	55.13	56.57	52.13
Only index persons	52.59	53.62	50.79

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	91	60	31
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	49.94	49.84	50.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
94: Matched controls
940

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L60.2

ICD-10 Finland

Onychogryphosis

2753.5

89.1

QDH00

NOMESCO Finland

Avulsion of toe nail

78.3

17.5

70305

ICD-8 Finland

Diseases of nail, Onychogryphosis

+∞

17.2

B35.1

ICD-10 Finland

Tinea unguium

6.6

11.5

L84

ICD-10 Finland

Corns and callosities

14.5

10.3

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

5.1

8.4

E10.4

ICD-10 Finland

Type 1 diabetes mellitus, With neurological complications

49.2

7.9

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

27.6

7.7

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

4.2

7.4

SPAT1229

SPAT

Assessment of need for aid

6.9

7.4

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

32.8

7.3

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

9.5

7.1

L03.0

ICD-10 Finland

Cellulitis of finger and toe

4.7

7.0

D01BA02

ATC

terbinafine; oral

3.3

6.9

149

7038C

ICD-9 Finland

Diseases of nail, Other specified diseases of nail[ONYCHOGRYPHOSIS]

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

363

3.39

7.23

2.2

2.0

88.06

98.89

pmol/l

1.17

181

(46235355) HIV 1 and 2 tests - Meaningful Use set

104

3.41

6.30

2.4

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.36

5.87

3.8

1.7

—

(3000494) Fungus identified in Specimen by Culture

3.36

5.55

1.6

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.58

5.32

2.6

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

390

2.73

5.07

3.3

2.6

—

estimate

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

4.06

5.00

4.9

3.5

23.67

24.60

mmol/l

0.51

(3021960) Folate [Moles/volume] in Serum or Plasma

246

2.59

4.85

1.6

1.7

16.96

22.96

nmol/l

2.45

205

(3019225) pH of Specimen

3.22

4.73

13.1

4.3

7.38

7.35

0.62

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

204

2.56

4.55

2.9

2.3

—

(3023368) Bacteria identified in Blood by Culture

209

2.48

4.28

4.7

4.5

—

(3032080) INR in Blood by Coagulation assay

382

2.46

4.25

22.6

14.9

1.32

1.20

inr

0.76

321

(42870588) Differential panel, method unspecified - Blood

267

2.42

4.22

10.5

5.3

—

(3006504) Eosinophils/Leukocytes in Blood

378

2.40

4.04

9.7

5.9

3.16

2.94

0.42

355

(3012544) pH of Venous blood

3.05

4.03

4.5

3.2

7.37

7.39

0.80

(3044640) Blood type and Crossmatch panel - Blood

264

2.35

3.98

3.1

2.4

—

(3022313) Gas panel - Capillary blood

4.03

3.90

10.6

3.7

—

(40768443) Skin Pathology biopsy report

4.59

3.86

1.3

—

(3019069) Monocytes/Leukocytes in Blood

383

2.34

3.85

10.0

6.1

8.70

8.68

0.02

361

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

12.68

3.81

1.3

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

12.68

3.81

1.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.79

3.72

2.9

1.5

—

(3022096) Basophils/Leukocytes in Blood

378

2.29

3.69

10.2

5.9

0.79

0.72

0.56

353

(3037121) Protein [Mass/volume] in Urine

4.65

3.64

6.9

3.6

648.00

175.09

mg/l

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

10.56

3.55

1.0

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.14

3.54

2.1

1.9

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

481

2.37

3.52

7.0

4.8

6.97

6.65

mmol/l

0.52

454

(3003458) Phosphate [Moles/volume] in Serum or Plasma

104

2.60

3.51

17.7

4.4

1.10

1.03

mmol/l

0.58

(3018010) Neutrophils/Leukocytes in Blood

385

2.22

3.44

9.5

6.1

59.81

57.32

0.90

368

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

119

2.50

3.44

6.9

4.8

35.47

32.58

0.42

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.01

3.44

2.2

2.3

—

(3013512) EKG study

304

2.18

3.40

4.6

3.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.27

3.28

1.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

533

2.36

3.21

6.6

4.5

—

5990.80

—

(3049717) Cytology report of Urine Cyto stain

4.35

3.19

2.1

2.9

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

182

2.15

2.89

1.8

1.9

439.25

461.08

pmol/l

0.15

154

(40761535) Cells panel - Urine sediment

2.78

2.87

4.7

3.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.05

2.76

1.3

1.5

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

6.32

2.74

1.7

1.3

—

(3013115) Eosinophils [#/volume] in Blood

427

2.03

2.72

9.6

6.4

0.20

0.19

e9/l

0.14

369

(3012095) Magnesium [Moles/volume] in Serum or Plasma

147

2.17

2.70

2.3

2.7

0.81

mmol/l

0.02

135

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

262

2.00

2.68

3.3

3.5

1723.61

1184.71

ng/l

0.44

219

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

125

2.24

2.66

2.7

2.0

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

362

1.98

2.66

2.9

2.4

80.91

77.75

nmol/l

0.35

328

(3004588) Protein electrophoresis panel - Serum or Plasma

2.80

2.57

1.2

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

464

1.99

2.51

10.8

10.3

3.69

3.95

e9/l

0.68

398

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

5.26

2.44

1.5

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

147

2.06

2.34

2.2

1.8

1152.45

1281.88

nmol/l

0.31

116

(3042936) Bacteria identified in Isolate by Culture

124

2.13

2.33

4.1

2.1

—

(3019198) Lymphocytes [#/volume] in Blood

422

1.89

2.31

9.7

5.8

1.58

1.77

e9/l

1.01

368

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.25

2.31

3.7

7.9

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

120

2.09

2.16

5.2

2.8

4.26

1.17

e6/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

287

1.84

2.15

6.8

3.8

18.07

10.76

mg/mmol

0.31

170

(3000991) Gas panel - Venous blood

2.44

2.13

14.7

7.7

—

(3009508) Creatinine [Moles/volume] in Urine

297

1.83

2.12

5.3

3.0

6.30

7.51

mmol/l

1.17

250

(3002256) Pathology report gross observation

106

2.13

2.11

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.49

2.08

1.5

1.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

282

1.81

2.03

6.8

2.9

—

(3012516) Albumin [Mass/volume] in Urine

283

1.80

2.00

5.5

3.2

100.18

57.95

mg/l

0.31

172

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

330

1.77

1.96

5.1

4.1

83.77

46.18

ng/l

0.46

237

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

416

1.78

1.95

16.9

6.2

1.20

1.22

mmol/l

0.54

363

(40768804) Tissue Pathology biopsy report

333

1.75

1.88

2.2

2.0

—

(3026008) Bacteria identified in Urine by Culture

260

1.70

1.64

4.4

3.0

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

3.13

1.61

1.2

1.1

—

(3019977) pH of Arterial blood

1.96

1.55

9.1

6.3

7.41

7.43

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.37

1.52

14.3

8.1

24.20

24.28

mmol/l

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.94

1.51

9.2

6.2

4.90

5.10

kpa

0.42

(3030467) Casts [#/volume] in Urine by Automated count

221

1.68

1.49

5.6

2.8

0.78

0.24

e6/l

0.63

156

(3028026) IgM [Mass/volume] in Serum or Plasma

2.31

1.45

1.6

1.7

1.28

1.18

g/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

782

2.17

1.42

30.5

16.1

26.68

23.82

mg/l

0.35

637

(3025941) Bacteria identified in Stool by Culture

2.32

1.41

1.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.05

1.37

1.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.05

1.37

5.6

1.4

—

(3015736) pH of Urine

336

1.58

1.35

5.0

3.4

6.14

6.16

0.04

186

(3035350) Ketones [Presence] in Urine by Test strip

423

1.58

1.34

5.5

3.9

0.00

estimate

-0.00

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.60

1.32

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

175

1.67

1.32

1.9

1.7

0.92

1.08

mg/l

0.19

141

(3002582) Erythrocytes [#/volume] in Urine

264

1.59

1.30

5.6

2.9

44.35

292.07

e6/l

0.49

198

(3026493) Urate [Moles/volume] in Serum or Plasma

213

1.60

1.23

4.1

2.8

411.36

332.80

umol/l

3.75

183

(40761511) CBC panel - Blood by Automated count

801

2.16

1.22

26.0

14.6

—

(3009261) Glucose [Presence] in Urine by Test strip

430

1.53

1.20

5.5

3.9

0.27

0.00

estimate

0.47

(3021601) Nitrite [Presence] in Urine by Test strip

421

1.53

1.19

5.6

3.8

0.00

estimate

-0.00

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.82

1.16

6.4

3.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.94

1.15

1.3

1.4

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

765

1.92

1.13

24.8

16.2

75.24

79.30

ml/min/173m2

0.68

707

(3019060) Gas panel - Arterial blood

1.99

1.06

1.4

3.8

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.34

1.04

1.0

5.0

91.16

45.07

mg/l

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.34

1.04

1.0

5.0

69.88

25.36

mg/l

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.34

1.04

1.6

2.0

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

821

2.12

1.02

33.9

18.6

139.47

139.75

mmol/l

0.46

805

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.08

1.02

1.9

2.5

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.85

1.02

1.2

1.4

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

820

2.15

1.02

34.8

18.6

4.02

3.97

mmol/l

0.68

801

(3029937) Albumin [Presence] in Urine by Test strip

240

1.51

1.02

4.7

3.9

0.00

estimate

-0.00

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

460

1.47

1.02

3.0

2.9

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.84

0.95

6.9

3.1

37.00

31.45

u/l

0.37

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

775

1.79

0.93

7.0

5.1

6.37

6.00

mmol/l

0.67

717

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.88

0.92

14.2

7.6

0.77

0.66

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.99

0.91

20.1

6.8

24.29

25.04

mmol/l

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.07

0.88

1.0

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.84

0.87

14.2

7.6

1.38

1.54

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

756

1.66

0.85

6.3

5.6

1.76

1.95

mu/l

0.85

700

(3018095) Leukocytes [#/volume] in Urine

296

1.41

0.83

7.4

3.6

212.48

80.40

e6/l

0.35

202

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.24

0.77

1.0

1.7

0.00

g/l

—

(3022145) Colonoscopy Study observation

101

1.58

0.76

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

632

1.42

0.73

5.1

4.7

14.94

14.88

pmol/l

0.06

578

(3002179) Metamyelocytes/Leukocytes in Blood

1.64

0.72

4.6

0.93

0.69

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.97

0.72

5.4

1.2

0.26

0.24

g/l

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.97

0.72

1.2

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

846

1.98

0.71

44.2

25.2

39.26

40.13

1.19

839

(3035941) MCH [Entitic mass]

846

1.98

0.71

42.4

24.7

30.52

30.37

0.34

839

(3007461) Platelets [#/volume] in Blood

846

1.98

0.71

42.7

24.8

253.74

251.57

e9/l

0.11

831

(3024731) MCV [Entitic mean volume] in Red Blood Cells

846

1.98

0.71

42.4

24.8

92.68

91.38

1.73

839

(3026361) Erythrocytes [#/volume] in Blood

846

1.98

0.71

42.6

24.8

4.28

4.45

e12/l

2.76

825

(3014576) Chloride [Moles/volume] in Serum or Plasma

103

1.54

0.70

12.0

6.4

104.67

104.04

mmol/l

0.17

103

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.72

0.70

1.0

1.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.90

0.69

5.4

1.2

1.22

1.17

g/l

—

(40761536) Microorganisms panel - Urine sediment

1.69

0.68

6.6

3.9

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

614

1.39

0.68

7.0

4.3

17.35

11.90

mm/h

1.91

565

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.57

0.67

2.8

1.7

—

(3043409) Potassium [Moles/volume] in Arterial blood

1.76

0.64

1.8

3.2

3.54

3.82

mmol/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

768

1.53

0.63

10.1

6.4

42.08

40.01

mmol/mol

1.09

725

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.57

0.63

2.3

2.0

1.63

1.49

0.31

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.61

0.0

2.6

—

16.60

—

(4024509) Urine culture

1.71

0.58

1.7

1.8

—

(40768797) Stomach Pathology biopsy report

126

1.43

0.56

1.4

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

796

1.52

0.54

7.1

6.0

2.61

2.69

mmol/l

0.36

735

(1761868) Lipid panel - Serum or Plasma

316

0.76

0.54

3.5

3.2

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

831

1.63

0.52

20.2

12.0

26.16

24.83

u/l

0.30

811

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.47

0.50

2.3

1.9

—

(3003694) ABO and Rh group [Type] in Blood

222

1.30

0.48

1.7

1.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.49

0.48

3.1

2.6

0.89

1.22

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.49

0.48

3.1

2.5

0.71

0.61

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

648

0.80

0.43

28.3

20.3

13.91

13.71

0.67

643

(3041096) Erythrocytes [Presence] in Urine by Automated

235

1.27

0.43

4.0

3.1

0.00

estimate

—

(3025159) Blasts/Leukocytes in Blood

1.44

0.43

4.7

5.2

0.00

—

(3017181) Myelocytes/Leukocytes in Blood

1.42

0.40

5.0

4.6

0.67

0.79

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

535

1.22

0.36

4.9

3.1

74.91

43.48

u/l

1.24

511

(3021440) Promyelocytes/Leukocytes in Blood

1.41

0.36

5.4

4.9

0.00

0.10

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

318

1.21

0.35

4.5

3.8

0.00

estimate

—

(3019150) Specific gravity of Urine by Refractometry

187

1.23

0.30

5.0

4.0

1.01

1.02

kg/l

1.11

123

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

181

0.80

0.28

2.0

3.0

2.48

2.45

mmol/l

0.71

164

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

115

1.26

0.25

1.3

1.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

741

1.22

0.24

5.6

4.3

1.37

1.27

mmol/l

0.70

676

(1002224) Polysomnography panel

1.37

0.24

1.4

1.1

—

(3020891) Body temperature

1.26

0.23

4.8

4.1

36.72

36.92

°c

—

(40758558) Short blood count panel - Blood

241

1.17

0.22

5.0

6.2

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

0.61

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

3.72

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.21

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

1.7

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

165

1.19

0.21

1.3

12.49

24.89

iu/ml

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

3.3

—

32.31

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(3000012) Reticulocyte production index

0.00

0.21

0.0

3.4

—

0.90

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

1.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.16

0.19

1.0

1.4

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.14

0.16

8.3

4.0

1.24

1.22

mmol/l

—

(4035726) Immunohistochemistry procedure

1.12

0.15

1.4

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

123

1.16

0.13

1.5

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

182

1.13

0.12

6.9

5.1

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.08

0.09

1.0

1.3

—

31.90

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.04

0.07

1.1

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

177

1.09

0.07

4.9

4.6

32.35

22.93

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

788

1.10

0.06

6.7

5.2

4.52

4.66

mmol/l

0.62

730

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

150

1.08

0.04

1.3

1.4

0.94

12.60

u/ml

—

(3018418) pH of Serum or Plasma

259

0.95

0.03

6.6

3.8

7.39

7.40

0.36

183

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

142

1.07

0.02

2.8

2.9

0.80

0.83

ug/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

782

1.06

0.02

6.6

5.1

1.42

1.51

mmol/l

1.05

719

(3007164) IgA [Mass/volume] in Serum or Plasma

183

1.05

0.01

1.7

1.4

2.41

2.60

g/l

0.20

102

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

348

1.01

0.00

2.2

2.0

1.41

1.33

mmol/l

0.27

287

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

6.70

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.0

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.2

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

-0.00

0.0

3.4

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

14.60

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.6

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.3

—

226.54

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.0

—

44.60

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

2.1

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.0

—

100.17

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.7

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.6

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

72.40

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.1

—

(36660697) Celiac disease serology panel - Serum

0.93

-0.00

1.3

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.7

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.6

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.02

-0.00

3.0

1.5

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

90.28

—

(44806071) Cardiolipin IgM antibody measurement

0.00

-0.00

0.0

1.2

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.0

—

7.60

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

1.8

—

13.33

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3039429) Cortisol [Moles/volume] in Saliva (oral fluid)

0.00

-0.00

0.0

1.8

—

27.48

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3000492) Spirometry study

0.94

-0.00

1.3

1.5

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

20.26

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.7

—

(4195642) Thrombophilia screening test

0.00

-0.00

0.0

1.0

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

8.90

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

-0.00

0.0

1.2

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_NAIL_GRYPHOSIS and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_NAIL_GRYPHOSIS	1.729 [1.08, 2.77]	0.023
Birth year	0.996 [0.99, 1.0]	0.325

During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 308 females with L12_NAIL_GRYPHOSIS died.

Males

Parameter	HR [95% CI]	p-value
L12_NAIL_GRYPHOSIS	1.993 [1.26, 3.15]	0.003
Birth year	0.984 [0.97, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 199 males with L12_NAIL_GRYPHOSIS died.

Mortality risk

Mortality risk for people of age

years, who have L12_NAIL_GRYPHOSIS.

N-year risk	Females	Males
1	0.15%	0.353%
5	0.942%	2.183%
10	2.462%	5.526%
15	4.902%	10.297%
20	8.73%	16.677%

Relationships between endpoints

↥

Index endpoint: L12_NAIL_GRYPHOSIS – Onychogryphosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Onychogryphosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints