No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
256 |
4. Check minimum number of eventsNone |
256 |
5. Include endpointsNone |
256 |
6. Filter based on genotype QC (FinnGen only) |
232 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60
- Name in latin
- Dystrophia unguium
Similar endpoints
↥List of similar endpoints to
Nail dystrophy
based on the number of shared cases.
Similar with more cases:
- Nail disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1588 | 915 | 667 |
| Only index persons | 1462 | 851 | 611 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 45.42 | 50.45 | 38.41 |
| Only index persons | 45.88 | 50.41 | 39.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 232 | 137 | 95 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 53.99 | 53.51 | 54.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 238
- Matched controls
- 2380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L60.3
ICD-10 Finland
Nail dystrophy
16384.0
303.9
223
*
S22
ICPC
Nail symptom/complaint
5.4
19.8
44
96
L60.0
ICD-10 Finland
Ingrowing nail
7.1
19.8
32
51
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.8
18.5
47
115
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.7
15.0
38
92
D01BA02
ATC
terbinafine; oral
3.1
15.0
89
385
QDH00
NOMESCO Finland
Avulsion of toe nail
159.4
14.6
15
*
L60.9
ICD-10 Finland
Nail disorder, unspecified
17.6
13.7
21
13
QCH00
NOMESCO Finland
Avulsion of finger nail
+∞
13.7
13
*
B35.1
ICD-10 Finland
Tinea unguium
4.5
13.4
35
87
L40.0
ICD-10 Finland
Psoriasis vulgaris
6.1
11.7
21
37
D01AE16
ATC
amorolfine; topical
3.3
10.4
44
153
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.7
10.0
66
294
Z2221
NOMESCO Finland
Medical doctor
2.5
9.7
81
405
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.6
9.6
35
110
D07AD01
ATC
clobetasol; topical
2.9
9.6
54
221
RJ421, ,
NOMESCO Finland
51.9
8.7
10
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.4
8.2
32
105
J02AC02
ATC
itraconazole; systemic
2.6
8.2
57
259
H02AB07
ATC
prednisone; oral
3.0
8.2
39
145
RJ420, ,
NOMESCO Finland
34.6
8.1
10
*
L60.1
ICD-10 Finland
Onycholysis
19.1
7.7
11
6
Z3231
NOMESCO Finland
Registered nurse
2.2
7.6
81
444
QDH01
NOMESCO Finland
Excision of nail bed in toe
82.6
7.5
8
*
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.1
7.4
21
55
70300
ICD-8 Finland
Diseases of nail, Dystrophia unguium
+∞
7.3
7
*
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.9
7.1
36
138
Z3226
NOMESCO Finland
Physiotherapist
2.4
7.1
57
276
D07AC01
ATC
betamethasone; topical
2.1
7.1
98
593
ZXA05
NOMESCO Finland
Left side
2.2
6.8
67
353
WX892
NOMESCO Finland
Monitored bed care
3.4
6.6
24
75
UJF30
NOMESCO Finland
Ileoscopy through colon
2.8
6.5
34
133
L17
ICPC
Foot/toe symptom/complaint
2.1
6.4
92
559
E0000UV, ,
ATC
2.0
6.4
108
696
7038A
ICD-9 Finland
Diseases of nail, Other specified diseases of nail[DYSTROPHIA UNGUIUM]
+∞
6.3
6
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.1
124
849
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
142
923
2.33
9.20
6.3
4.7
35.45
35.71
g/l
0.20
129
880
74
421
2.10
6.13
3.8
3.4
149.28
241.66
ng/l
0.41
57
319
33
134
2.70
5.84
2.8
2.8
83.18
159.84
ng/l
1.63
33
122
197
1606
2.32
5.77
10.5
8.3
72.68
78.11
u/l
2.13
192
1514
134
967
1.88
5.38
3.2
2.4
81.36
76.36
nmol/l
1.15
121
859
144
1064
1.89
5.36
11.1
7.5
1.22
1.21
mmol/l
0.71
131
918
18
54
3.52
5.28
3.3
3.3
1.69
1.00
index
0.36
13
28
43
208
2.30
5.26
2.3
2.4
35.89
29.69
u/l
0.54
35
169
82
522
1.87
4.75
3.3
2.1
2.21
3.02
mg/l
2.80
71
448
10
15
6.90
4.51
1.0
1.3
6.08
7.95
u/l
—
5
15
157
1228
1.82
4.51
11.2
10.2
3.88
4.09
e9/l
0.49
139
1077
29
133
2.34
3.99
1.2
1.2
265.83
130.57
u/ml
0.77
16
54
188
1583
1.89
3.93
5.7
4.2
13.63
11.64
mm/h
1.07
176
1462
58
350
1.87
3.88
3.2
3.1
1.27
2.86
e6/l
1.32
29
166
159
1281
1.73
3.79
6.4
5.4
6.53
6.62
mmol/l
0.20
150
1202
31
150
2.23
3.78
4.3
3.3
83.38
74.29
ng/l
0.26
26
131
107
781
1.67
3.67
3.1
3.1
—
—
—
0
0
227
2079
2.99
3.40
20.5
15.3
31.08
23.10
mg/l
1.94
198
1691
18
71
2.66
3.38
3.3
2.7
—
—
—
0
0
13
38
3.56
3.37
1.5
1.4
—
—
—
0
0
13
38
3.56
3.37
1.5
1.4
—
—
—
0
0
125
968
1.61
3.28
9.5
6.7
1.22
1.22
mmol/l
0.50
118
898
34
181
2.02
3.26
1.4
1.4
—
—
—
0
0
10
24
4.30
3.23
1.1
1.3
—
—
—
0
0
10
24
4.30
3.23
1.1
1.3
—
—
—
0
0
87
618
1.64
3.23
3.0
3.1
0.29
0.37
e6/l
0.19
65
441
10
25
4.13
3.12
1.1
1.3
—
—
—
0
0
10
25
4.13
3.12
1.1
1.3
—
—
—
0
0
59
385
1.71
2.99
3.2
2.9
0.58
1.02
e6/l
1.14
31
198
5
5
10.17
2.99
1.0
1.6
—
—
—
0
0
126
994
1.57
2.94
4.9
2.8
75.63
107.08
ug/l
3.98
119
919
15
59
2.65
2.84
1.5
1.6
0.02
0.08
iu/ml
—
5
10
10
28
3.68
2.82
1.1
1.3
—
—
—
0
0
43
262
1.78
2.76
1.6
1.8
—
—
—
0
0
10
29
3.55
2.72
1.1
1.2
—
—
—
0
0
118
931
1.53
2.67
2.6
2.0
101.74
97.70
pmol/l
0.33
56
455
54
356
1.67
2.62
1.7
1.9
—
—
—
0
0
14
58
2.50
2.42
1.4
1.2
—
—
—
0
0
124
1004
1.49
2.40
2.8
2.9
—
—
estimate
—
0
0
140
1164
1.49
2.36
7.4
6.9
10.21
10.80
umol/l
0.47
135
1098
186
1644
1.60
2.34
5.4
4.2
14.60
14.88
pmol/l
0.84
177
1492
75
549
1.53
2.34
2.4
2.8
335.90
344.92
umol/l
0.32
69
478
85
640
1.51
2.32
1.8
2.1
158.27
171.24
u/l
0.14
79
603
7
18
3.97
2.27
1.0
1.0
—
—
—
0
0
13
54
2.49
2.24
1.4
1.2
—
—
—
0
0
40
254
1.69
2.23
1.7
1.9
—
—
—
0
0
8
25
3.27
2.11
1.0
1.1
—
—
—
0
0
5
10
5.08
2.08
1.8
3.5
0.60
0.70
index
—
5
10
8
26
3.15
2.03
1.0
1.1
—
—
—
0
0
70
521
1.49
1.99
2.7
2.5
—
—
—
0
0
37
239
1.65
1.94
11.3
10.7
1.99
0.91
mmol/l
0.85
29
206
52
365
1.54
1.94
1.6
1.3
13.60
9.83
u/ml
0.14
13
140
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
12
4.23
1.83
1.0
1.3
—
—
—
0
0
82
640
1.43
1.80
2.9
3.2
783.23
1187.10
ng/l
1.13
69
533
211
1960
1.67
1.75
6.7
5.2
1.98
1.90
mu/l
0.46
199
1797
7
24
2.97
1.73
3.7
4.4
—
—
—
0
0
21
120
1.82
1.68
1.3
1.7
—
—
—
0
0
6
19
3.21
1.67
1.5
1.5
—
—
—
0
0
79
620
1.41
1.67
1.7
1.7
19.08
21.59
nmol/l
0.82
71
511
7
25
2.85
1.66
1.1
1.4
—
—
—
0
0
92
746
1.38
1.59
4.7
3.0
2.34
2.36
mmol/l
0.79
84
668
7
26
2.74
1.59
1.1
1.8
—
—
—
0
0
6
20
3.05
1.59
1.2
1.2
—
—
—
0
0
41
288
1.51
1.53
12.3
8.0
102.93
103.95
mmol/l
0.64
41
288
7
27
2.64
1.52
12.3
1.9
11.43
10.40
mmol/l
—
7
27
10
45
2.28
1.48
1.6
1.4
—
—
—
0
0
9
39
2.36
1.44
3.8
2.7
—
981.17
—
0
6
46
335
1.46
1.44
1.4
1.7
918.04
1220.07
nmol/l
2.48
37
248
6
22
2.77
1.44
1.0
1.1
—
—
—
0
0
14
75
1.92
1.37
2.0
2.0
60.43
366.54
ug/l
2.61
14
70
51
661
0.71
1.36
3.7
3.9
0.00
0.01
estimate
0.74
23
229
5
17
2.98
1.36
1.4
1.2
—
—
—
0
0
228
2188
2.00
1.35
16.8
12.0
26.36
27.10
u/l
0.26
222
2120
6
24
2.54
1.31
1.2
1.9
—
—
—
0
0
5
18
2.81
1.29
1.2
1.1
—
—
—
0
0
63
496
1.37
1.28
2.4
1.8
1.03
1.25
mg/l
0.44
51
385
21
132
1.65
1.25
2.4
3.7
25.14
24.66
mmol/l
0.25
21
132
23
149
1.60
1.22
2.3
1.4
—
—
—
0
0
32
224
1.50
1.22
4.0
4.8
12.86
25.98
ug/l
0.26
20
185
87
726
1.31
1.19
4.5
3.9
2.94
10.37
mg/mmol
3.50
59
455
31
217
1.49
1.19
2.8
3.6
2.10
2.02
mmol/l
0.05
31
183
12
65
1.89
1.15
2.0
1.4
—
—
—
0
0
21
136
1.60
1.13
14.0
8.3
26.59
24.81
mmol/l
1.21
21
136
51
396
1.37
1.13
1.6
1.3
12.77
31.70
iu/ml
1.98
13
119
156
1414
1.30
1.12
3.5
3.4
36.12
46.72
u/l
2.44
147
1330
207
1957
1.44
1.10
7.2
6.3
39.59
39.32
mmol/mol
0.18
198
1833
31
226
1.43
0.99
2.4
2.2
—
—
—
0
0
106
926
1.26
0.98
2.4
2.0
1.37
1.38
mmol/l
0.04
96
762
12
69
1.78
0.98
1.5
1.7
—
—
—
0
0
11
62
1.81
0.96
1.4
1.5
10.80
7.75
u/l
0.31
11
52
16
242
0.64
0.95
8.9
6.9
—
—
—
0
0
19
126
1.55
0.94
1.5
1.4
—
42.83
—
0
13
12
70
1.75
0.94
1.0
1.3
—
—
—
0
0
9
52
1.76
0.93
1.1
1.5
—
—
—
0
0
8
42
1.94
0.89
1.3
1.5
—
—
—
0
0
45
357
1.32
0.87
4.3
3.0
0.61
0.78
ug/l
1.46
36
218
12
72
1.70
0.87
3.4
2.8
1.70
1.44
mg/l
0.95
12
63
12
72
1.70
0.87
3.3
3.2
26.10
25.18
mmol/l
0.34
12
67
6
31
1.96
0.85
1.2
1.1
—
—
—
0
0
52
423
1.29
0.85
4.4
2.8
2.45
2.46
mmol/l
0.06
41
375
144
1317
1.24
0.84
3.3
3.0
—
—
—
0
0
12
73
1.68
0.83
1.6
1.9
—
—
—
0
0
79
908
0.81
0.82
3.5
3.7
0.00
0.02
estimate
0.68
16
207
8
47
1.73
0.81
1.1
1.4
—
—
—
0
0
6
33
1.84
0.79
1.2
1.1
—
—
—
0
0
129
1172
1.22
0.78
4.0
3.9
0.00
0.00
estimate
-0.00
24
246
7
39
1.82
0.73
1.7
1.2
—
—
—
0
0
9
58
1.57
0.70
1.3
1.2
—
—
—
0
0
39
315
1.28
0.68
1.8
1.4
—
—
—
0
0
129
1185
1.19
0.66
4.1
3.9
0.00
6.55
estimate
0.50
23
248
64
554
1.21
0.62
1.3
1.3
0.80
1.63
u/ml
0.85
12
136
8
50
1.62
0.62
1.3
1.4
—
—
—
0
0
31
247
1.29
0.60
2.7
2.3
—
—
—
0
0
209
2018
1.29
0.60
6.0
5.1
5.84
5.93
mmol/l
0.62
197
1854
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
8
52
1.56
0.60
1.3
1.4
—
—
—
0
0
129
1192
1.18
0.60
4.1
4.0
0.00
0.00
estimate
-0.00
21
235
52
443
1.22
0.59
1.9
1.8
425.32
449.25
pmol/l
0.34
41
367
45
527
0.82
0.55
3.7
3.9
1.02
1.02
kg/l
0.71
29
344
9
62
1.47
0.53
1.4
1.2
—
—
—
0
0
9
63
1.45
0.53
1.2
1.4
—
—
—
0
0
10
68
1.49
0.47
1.3
1.4
151.60
289.98
miu/ml
—
5
29
206
1998
1.23
0.47
19.5
15.4
85.42
82.53
ml/min/173m2
1.09
199
1834
13
175
0.73
0.46
1.9
3.7
1.23
1.23
mmol/l
0.03
13
154
15
112
1.36
0.46
3.7
2.1
—
—
—
0
0
213
2075
1.25
0.45
6.7
5.9
2.62
2.72
mmol/l
0.96
201
1926
5
32
1.57
0.42
1.6
1.7
0.51
0.47
nmol/l
—
5
25
8
58
1.39
0.42
1.4
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
8
60
1.34
0.40
1.1
1.4
—
—
—
0
0
5
34
1.48
0.40
1.2
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
9
71
1.28
0.36
1.3
1.2
0.81
0.91
g/l
—
9
71
5
80
0.62
0.36
1.4
2.1
—
—
—
0
0
16
127
1.28
0.34
1.0
1.0
—
—
—
0
0
6
46
1.31
0.33
1.3
1.2
—
—
—
0
0
47
422
1.14
0.31
2.0
1.6
—
—
—
0
0
210
2057
1.18
0.30
5.9
5.1
4.56
4.64
mmol/l
0.68
198
1915
10
76
1.33
0.28
3.5
4.0
39.11
57.02
mg/l
—
10
63
17
142
1.21
0.25
3.1
3.2
141.41
130.07
g/l
1.79
17
137
5
40
1.26
0.22
1.2
1.5
—
—
—
0
0
5
42
1.19
0.21
1.4
1.5
65.98
48.38
ug/l
—
5
42
19
164
1.17
0.21
1.7
1.8
2.90
3.39
mmol/l
1.57
12
127
16
136
1.19
0.20
4.3
2.1
—
—
—
0
0
6
48
1.26
0.20
1.5
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
3.6
—
1.21
—
0
14
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
208
2049
1.12
0.19
5.7
5.0
1.47
1.48
mmol/l
0.05
196
1898
8
70
1.15
0.16
1.3
1.2
1.50
1.54
g/l
—
8
70
50
474
1.07
0.12
5.3
4.5
23.05
22.20
%
0.17
30
221
17
187
0.90
0.10
2.1
2.3
0.02
0.17
e6/l
4.26
17
179
193
1952
0.94
0.10
5.0
4.2
1.33
1.28
mmol/l
0.45
176
1798
6
55
1.09
0.09
1.3
1.9
—
—
—
0
0
24
224
1.08
0.08
2.5
2.0
3.11
3.29
ratio
0.30
16
187
6
57
1.05
0.08
1.7
1.6
—
—
—
0
0
12
130
0.92
0.04
2.4
2.7
0.51
0.61
%
0.55
12
130
71
696
1.03
0.04
2.5
2.6
73.44
62.35
u/l
0.23
64
639
11
117
0.94
0.02
1.3
1.4
—
—
—
0
0
13
132
0.98
0.00
2.2
2.7
1.45
1.27
%
0.16
13
132
23
229
1.00
0.00
2.2
3.4
—
—
—
0
0
84
842
1.00
0.00
2.7
3.7
32.11
32.58
ng/l
0.01
48
600
14
144
0.97
0.00
23.6
10.8
93.16
94.14
%
0.36
14
144
66
665
0.99
0.00
3.2
3.2
0.00
0.00
estimate
-0.00
15
203
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
61
0.98
0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
6
61
0.98
0.00
1.2
1.1
—
20.84
—
0
8
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
26
260
1.00
-0.00
4.4
4.7
39.47
31.95
%
1.82
15
165
6
59
1.02
-0.00
1.2
1.5
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
5.86
—
0
5
0
9
0.00
-0.00
0.0
2.3
—
198.11
—
0
9
0
5
0.00
-0.00
0.0
1.6
—
1.23
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
8.89
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
10.50
—
0
9
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
11
110
1.00
-0.00
1.3
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
4.60
—
0
9
0
9
0.00
-0.00
0.0
1.3
—
62.74
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAIL_DYSTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_DYSTROPHY | 1.491 [1.13, 1.97] | 0.005 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 782 females with L12_NAIL_DYSTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_DYSTROPHY | 1.187 [0.87, 1.62] | 0.285 |
| Birth year | 0.988 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 524 males with L12_NAIL_DYSTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAIL_DYSTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.129% | 0.238% |
| 5 | 0.734% | 1.34% |
| 10 | 1.892% | 3.472% |
| 15 | 3.565% | 6.6% |
| 20 | 6.123% | 11.305% |
Relationships between endpoints
↥Index endpoint: L12_NAIL_DYSTROPHY – Nail dystrophy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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