Cutaneous lupus erythematosus

L12_LUPUS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L93#
  • Hospital discharge: ICD-9 6954
  • Hospital discharge: ICD-8 6954|68611
  • Cause of death: ICD-10 L93#
  • Cause of death: ICD-9 6954
  • Cause of death: ICD-8 6954|68611

2 out of 7 registries used, show all original rules.

996

4. Check minimum number of events

None

996

5. Include endpoints

None

996

6. Filter based on genotype QC (FinnGen only)

904

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Lupus erythematosus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5703 4197 1469
Only index persons 5048 3789 1259
Unadjusted period prevalence (%)
Whole population 0.10 0.12 0.04
Only index persons 0.12 0.14 0.05
Median age at first event (years)
Whole population 54.73 55.76 51.68
Only index persons 53.96 55.11 50.50

-FinnGen-

Key figures

All Female Male
Number of individuals 904 688 216
Unadjusted period prevalence (%) 0.21 0.24 0.10
Median age at first event (years) 54.68 53.54 58.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
936
Matched controls
9360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P01BA02
ATC
hydroxychloroquine; oral
35.4
307.7
598
446
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
144.0
307.7
212
19
L93.0
ICD-10 Finland
Discoid lupus erythematosus
8606.6
307.7
740
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
25.2
307.7
464
351
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.0
157.6
308
616
L93.1
ICD-10 Finland
Subacute cutaneous lupus erythematosus
+∞
152.4
142
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.7
151.8
437
1244
D07AB08
ATC
desonide; topical
6.7
143.2
281
560
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
14.6
123.4
116
90
D07AC01
ATC
betamethasone; topical
4.7
119.4
580
2402
L93.2
ICD-10 Finland
Other local lupus erythematosus
+∞
117.2
110
*
D07AD01
ATC
clobetasol; topical
5.0
114.9
338
949
D07AC13
ATC
mometasone; topical
4.3
105.8
486
1891
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
22.3
101.5
76
37
L04AX01
ATC
azathioprine; systemic
9.7
100.7
125
146
D07AB02
ATC
hydrocortisone butyrate; topical
4.1
99.1
482
1932
L04AA06
ATC
mycophenolic acid; systemic
17.4
91.7
77
48
E0000UV, ,
ATC
3.6
79.2
570
2837
L04AX03
ATC
methotrexate; systemic
4.8
78.8
210
530
H02AB06
ATC
prednisolone; systemic
3.5
71.7
619
3371
P01BA01
ATC
chloroquine; systemic
31.5
68.5
45
15
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.2
68.3
157
348
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
12.6
67.7
68
58
L93
ICD-10 Finland
Lupus erythematosus
+∞
66.5
63
*
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
88.7
59.8
66
8
XQ848
NOMESCO Finland
Dermatological photography
8.5
53.0
71
90
E000001, ,
ATC
3.1
49.9
280
1139
TQW80
NOMESCO Finland
Local dermatologic skincare
9.9
49.4
58
62
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
164.7
45.2
47
*
L71.8
ICD-10 Finland
Other rosacea
9.3
42.3
52
59
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
414.6
40.4
40
*
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.6
39.9
100
235
69540
ICD-8 Finland
Erythematous condition, Lupus erythematosus
+∞
38.8
37
*
D06BX01
ATC
metronidazole; topical
3.2
38.1
177
636
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
36.8
452
2633
C08CA05
ATC
nifedipine; systemic
4.2
34.2
96
246
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
93.6
33.0
36
*
M32
ICD-10 Finland
Systemic lupus erythematosus
121.1
32.9
35
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
30.9
520
3373
D07XC01
ATC
betamethasone; topical
3.0
29.8
155
590
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
300.9
28.9
29
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
9.7
28.1
33
35
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
26.3
27.7
38
15
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.2
26.5
115
393
L71.9
ICD-10 Finland
Rosacea, unspecified
5.3
26.4
54
106
D02AX
ATC
Other emollients and protectives
5.2
26.4
55
110
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.2
25.3
108
365
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.6
24.7
161
686
L88
ICPC
Rheumatoid/seropositive arthritis
4.0
24.3
73
196
SBA10
NOMESCO Finland
Measurement of salivary flow rate
8.6
24.1
31
37
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
23.9
220
1096
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.7
22.4
134
545
L04AD01
ATC
ciclosporin; systemic
7.0
22.2
34
50
H02AB07
ATC
prednisone; oral
2.4
22.1
169
774
L43.9
ICD-10 Finland
Lichen planus, unspecified
5.9
21.3
39
69
H04.10
ICD-10 Finland
Dry eye syndrome
2.4
21.0
161
738
D05BB02
ATC
acitretin; oral
5.6
20.9
40
74
D07AA02
ATC
hydrocortisone; topical
2.4
20.3
165
775
J04BA02
ATC
dapsone; oral
49.2
20.2
24
5
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
204.1
19.6
20
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
19.0
102
391
E000002, ,
ATC
2.5
19.0
128
551
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
18.9
245
1383
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.0
18.1
86
309
M05BA04
ATC
alendronic acid; oral
2.5
17.9
125
546
L01BA01
ATC
methotrexate; systemic
3.8
17.7
55
151
XQ802
NOMESCO Finland
Epicutan test
3.6
17.5
60
176
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.6
17.5
108
445
M35.1
ICD-10 Finland
Other overlap syndromes
21.4
17.4
25
12
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.6
17.2
41
92
R50.9
ICD-10 Finland
Fever, unspecified
2.2
16.9
167
848
E000007, ,
ATC
3.1
16.7
71
239
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
5.5
16.5
32
60
R06AX27
ATC
desloratadine; oral
1.9
16.1
299
1891
6954A
ICD-9 Finland
Erythematous conditions, Lupus erythematosus[LUPUS ERYTHEMATOSUS DISCOIDES]
+∞
15.7
15
*
XX9XE
NOMESCO Finland
Other ultrasound examination
12.0
15.6
28
24
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
15.2
454
3287
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
5.9
15.0
27
47
L43.8
ICD-10 Finland
Other lichen planus
5.1
14.6
31
63
SBA00
NOMESCO Finland
Microbiological examinations
4.0
14.5
41
105
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
5.0
14.3
31
64
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
14.3
299
1948
J01FF01
ATC
clindamycin; systemic
1.8
14.2
267
1684
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.3
14.0
53
166
D02AE01
ATC
carbamide; topical
2.7
13.9
75
288
S97
ICPC
Chronic ulcer skin
3.0
13.7
63
222
R06AE07
ATC
cetirizine; oral
1.7
13.5
436
3190
L56.4
ICD-10 Finland
Polymorphous light eruption
13.1
13.4
23
18
A02BC02
ATC
pantoprazole; systemic
1.8
13.3
661
5414
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.6
12.9
77
312
A02BC05
ATC
esomeprazole; systemic
1.7
12.8
402
2907
SPAT1153
SPAT
Removal of sutures
1.7
12.8
302
2023
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
10.7
12.8
24
23
J05AB11
ATC
valaciclovir; oral
2.0
12.7
166
927
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
4.0
12.6
36
93
ZXC12
NOMESCO Finland
Pulse colorlaser
20.4
12.5
18
9
D02BB01
ATC
betacarotene; oral
20.4
12.5
18
9
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
12.3
291
1948
XPX04
NOMESCO Finland
Angioscopy
27.1
12.1
16
6
B07.9
ICD-10 Finland
Verruca simplex
3.3
11.9
44
136
XQ845
NOMESCO Finland
Dermatoscopy
4.6
11.7
28
63
J01MA12
ATC
levofloxacin; systemic
1.9
11.6
178
1046
J01DB01
ATC
cefalexin; oral
1.9
11.6
770
6690
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
11.6
393
2880
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.4
11.5
78
335
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.8
11.3
57
211
E000006, ,
ATC
2.4
11.1
77
334
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.1
11.1
106
527
H02AB04
ATC
methylprednisolone; systemic
1.9
11.1
145
809
L30.8
ICD-10 Finland
Other specified dermatitis
3.4
11.1
39
117
S99
ICPC
Skin disease other
3.8
11.0
34
93
N02AX02
ATC
tramadol; systemic, rectal
1.6
11.0
403
2997
A01AC01
ATC
triamcinolone; local oral
4.9
11.0
24
50
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.6
11.0
66
268
D07AC14
ATC
methylprednisolone aceponate; topical
2.7
10.9
58
221
R06AE09
ATC
levocetirizine; oral
1.9
10.9
146
820
J01AA07
ATC
tetracycline; systemic
1.9
10.8
153
875
D10BA01
ATC
isotretinoin; oral
2.7
10.8
60
234
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.7
10.7
59
229
6954B
ICD-9 Finland
Erythematous conditions, Lupus erythematosus[LUPUS ERYTHEMATOSUS DISCOIDES DISSEMINATUS]
+∞
10.4
10
*
XQ800
NOMESCO Finland
Prick test
2.3
10.4
78
351
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.1
10.4
99
492
J01DA01
ATC
[U] cefalexin
1.6
10.3
578
4719
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.1
10.3
42
138
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
10.3
119
635
L04AA13
ATC
[U] leflunomide
3.5
10.1
35
104
C03CA01
ATC
furosemide; systemic
1.6
10.1
265
1809
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.5
10.1
62
255
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.0
9.9
106
550
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
16.9
9.9
15
9
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
5.2
9.9
20
39
J01AA04
ATC
lymecycline; systemic
1.9
9.8
124
682
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.1
9.7
97
490
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
9.7
133
752
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
9.6
124
687
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.9
9.6
28
74
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
3.5
9.5
32
93
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
9.5
127
712
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.8
9.5
29
79
B02.9
ICD-10 Finland
Zoster without complication
2.2
9.4
80
380
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
12.5
9.4
16
13
R4120
NOMESCO Finland
Occupational therapy
2.3
9.4
71
321
UJF32
NOMESCO Finland
Coloscopy
1.6
9.2
244
1664
E000003, ,
ATC
2.7
9.1
49
188
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
9.1
229
1539
ZXC50
NOMESCO Finland
Cryotherapy
3.4
9.1
32
96
L04AA01
ATC
[U] ciclosporin
4.8
9.1
20
42
WZA10
NOMESCO Finland
Extensive medical or dental certificate
4.4
8.9
22
51
J05AB01
ATC
aciclovir; systemic
1.6
8.9
220
1473
K90.0
ICD-10 Finland
Coeliac disease
3.2
8.8
34
108
NF1AA
NOMESCO Finland
Hip X-ray examination
2.0
8.8
92
473
A01AB04
ATC
amphotericin B; local oral
2.5
8.8
55
228
A07AA02
ATC
nystatin; oral
2.3
8.8
65
291
JN4AD
NOMESCO Finland
Body CT examination
1.9
8.8
108
589
N03AX16
ATC
[U] pregabalin
1.6
8.8
218
1461
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.9
8.7
123
702
S06
ICPC
Rash localized
2.4
8.7
61
267
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
10.2
8.5
16
16
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.8
8.5
43
160
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
27.8
8.5
11
*
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
20.2
8.5
12
6
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.6
8.4
27
76
A02BC03
ATC
lansoprazole; oral
1.6
8.4
271
1929
WW200
NOMESCO Finland
Immunization
3.5
8.4
28
81
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.3
8.4
31
96
A02BC01
ATC
omeprazole; systemic
1.6
8.4
251
1757
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
3.8
8.4
25
67
TQW99
NOMESCO Finland
Other minor procedure on skin
2.5
8.3
51
210
R42
ICD-10 Finland
Dizziness and giddiness
1.6
8.3
222
1514
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.8
8.2
41
152
ZX120
NOMESCO Finland
Intravenous
2.0
8.2
91
479
M05BX04
ATC
denosumab; parenteral
2.1
8.1
75
368
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.6
8.1
47
188
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
4.1
8.1
22
55
M33.1
ICD-10 Finland
Other dermatomyositis
33.7
8.1
10
*
M25.5
ICD-10 Finland
Pain in joint
1.5
8.1
320
2381
J02AC01
ATC
fluconazole; systemic
1.5
8.0
385
2984
R05
ICD-10 Finland
Cough
1.6
7.9
208
1408
D06AX01
ATC
fusidic acid; topical
2.0
7.9
90
477
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
7.9
339
2564
D07BC01
ATC
betamethasone and antiseptics; topical
1.9
7.8
107
604
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
7.8
164
1050
I73.0
ICD-10 Finland
Raynaud syndrome
3.7
7.8
24
66
ECA20
NOMESCO Finland
Biopsy of gingiva
6.4
7.7
19
30
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
7.7
110
629
M05BA07
ATC
risedronic acid; oral
2.7
7.6
40
152
J01AA02
ATC
doxycycline; systemic
1.6
7.6
717
6332
L63.9
ICD-10 Finland
Alopecia areata, unspecified
12.0
7.6
13
11
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
25.2
7.6
10
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.4
7.6
49
207
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
7.5
264
1908
J01MA02
ATC
ciprofloxacin; systemic
1.5
7.5
329
2491
J01DC02
ATC
cefuroxime; systemic
2.3
7.5
54
239
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
13.5
7.4
12
9
SPAT1229
SPAT
Assessment of need for aid
2.1
7.4
72
361
L84
ICD-10 Finland
Corns and callosities
3.1
7.4
30
99
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
7.4
158
1016
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.9
7.4
97
541
S01
ICPC
Pain/tenderness of skin
2.4
7.3
50
216
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
7.3
210
1451
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
+∞
7.3
7
*
N16.4*M32.1
ICD-10 Finland
Renal tubulo-interstitial disorders in systemic lupus erythematosus
+∞
7.3
7
*
L98.64
ICD-10 Finland
Benign lymphocyte infiltration into the skin [Jessner-Kanof]
+∞
7.3
7
*
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
4.2
7.3
19
46
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.3
331
2523
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
7.3
99
558
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
7.2
119
711
S18
ICPC
Laceration/cut
1.5
7.2
419
3350
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
2.2
7.2
59
277
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.3
7.2
51
225
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
20.2
7.1
10
5
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
7.1
107
622
EKA10
NOMESCO Finland
iopsy of buccal mucosa
3.2
7.0
27
86
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
3.7
6.9
21
57
127
Kela drug reimbursment
Transplant complication
5.9
6.9
18
31
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
4.0
6.9
19
48
L43.0
ICD-10 Finland
Hypertrophic lichen planus
8.3
6.8
14
17
N02AA05
ATC
oxycodone; systemic
1.6
6.8
163
1077
Z2221
NOMESCO Finland
Medical doctor
1.5
6.8
241
1742
A01AB09
ATC
miconazole; local oral
1.9
6.8
84
459
C08CA02
ATC
felodipine; oral
1.9
6.8
87
481
R13
ICD-10 Finland
Dysphagia
2.0
6.8
70
359
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
40.4
6.8
8
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.1
6.7
60
291
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
3.3
6.7
24
73
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.8
6.7
101
588
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
22.7
6.7
9
*
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.6
6.7
38
151
UJF30
NOMESCO Finland
Ileoscopy through colon
1.8
6.7
101
589
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
4.1
6.6
18
45
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
7.9
6.6
14
18
SPF40
NOMESCO Finland
Removal and reattachment of crown or small bridge
3.6
6.6
21
59
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
2.7
6.6
35
134
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.6
195
1353
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
6.6
153
1003
M13.9
ICD-10 Finland
Arthritis, unspecified
2.0
6.5
70
364
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
6.5
136
867
A46
ICD-10 Finland
Erysipelas
1.7
6.5
115
701
L30.0
ICD-10 Finland
Nummular dermatitis
2.5
6.5
38
153
SPAT1263
SPAT
Sampling
1.4
6.5
365
2883
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.0
6.5
28
96
D07CC01
ATC
betamethasone and antibiotics; topical
1.7
6.5
116
710
SCA02
NOMESCO Finland
Preventive oral health care
1.8
6.5
94
541
I78.9
ICD-10 Finland
Disease of capillaries, unspecified
14.4
6.4
10
7
L30.3
ICD-10 Finland
Infective dermatitis
2.6
6.3
36
143
A02BA02
ATC
ranitidine; systemic
1.6
6.3
177
1212
R06.0
ICD-10 Finland
Dyspnoea
1.5
6.3
245
1800
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
9.3
6.3
12
13
B01AC04
ATC
clopidogrel; oral
1.7
6.2
133
853
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
4.0
6.2
17
43
S29
ICPC
Skin symptom/complaint other
1.5
6.2
183
1269
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.9
6.2
83
466
Z94.0
ICD-10 Finland
Kidney transplant status
7.7
6.1
13
17
S88
ICPC
Dermatitis contact/allergic
3.1
6.1
25
83
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.6
6.1
34
134
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
2.5
6.0
36
147
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.6
6.0
34
135

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
278
209
18.50
309.72
1.9
1.2
2.86
7.85
u/ml
0.38
34
13
330
272
18.19
307.65
2.1
1.2
67.83
29.88
u/ml
1.14
68
12
461
377
23.13
307.65
5.1
1.6
11.36
6.64
iu/ml
1.72
179
80
419
244
30.28
307.65
4.3
1.6
0.20
0.24
g/l
7.85
404
232
418
251
29.28
307.65
4.3
1.6
1.10
1.22
g/l
6.70
411
239
332
264
18.94
307.65
2.1
1.2
14.18
2.46
u/ml
1.23
73
25
357
337
16.51
307.65
1.9
1.3
2.66
1.28
u/ml
0.45
21
24
325
265
18.26
307.65
2.1
1.2
6.98
9.79
u/ml
0.23
110
38
276
210
18.22
305.29
2.0
1.2
59.35
48.42
u/ml
0.29
104
18
533
1210
8.91
255.52
2.4
1.4
867.45
560.00
titre
2.92
274
269
184
108
20.96
229.75
1.9
1.3
64.21
97.35
u/ml
—
14
6
256
320
10.64
200.97
1.5
1.2
—
—
—
0
0
148
127
13.65
148.83
1.6
1.1
2.17
20.50
u/ml
—
12
6
62
10
66.33
112.44
2.0
2.1
—
—
—
0
0
744
4312
4.54
83.67
12.6
5.9
0.04
0.04
e9/l
1.18
695
3675
742
4303
4.49
83.09
12.5
5.9
0.56
0.57
e9/l
0.24
694
3671
750
4446
4.46
79.79
12.8
6.1
0.17
0.18
e9/l
3.08
703
3857
744
4388
4.39
79.68
12.6
5.9
1.77
1.91
e9/l
2.62
700
3835
92
104
9.70
75.56
1.7
1.2
—
—
—
0
0
691
3966
3.84
74.88
12.7
6.0
9.32
8.73
%
5.68
673
3706
691
3972
3.83
74.56
12.3
5.9
56.74
57.10
%
0.36
679
3781
688
3964
3.78
73.49
12.6
5.9
2.62
2.78
%
1.21
667
3701
694
4042
3.77
72.39
12.7
6.0
28.13
28.04
%
0.08
678
3825
683
3951
3.70
71.71
12.8
6.0
0.70
0.69
%
0.32
665
3676
771
4844
4.36
70.95
15.5
9.5
3.71
4.06
e9/l
4.82
730
4218
555
2859
3.31
69.98
10.7
5.6
—
—
—
0
0
67
78
9.17
53.54
1.4
1.2
—
—
—
0
0
62
73
9.02
49.06
1.4
1.2
—
—
—
0
0
72
116
6.64
43.39
1.4
1.2
3.85
3.29
u/ml
0.21
41
49
42
34
12.89
42.92
1.2
1.1
1.88
10.33
u/ml
—
8
6
364
1902
2.50
38.10
8.6
4.6
—
—
—
0
0
178
648
3.16
37.48
3.6
2.9
11.40
10.88
g/l
0.74
171
599
55
78
7.43
37.21
2.3
2.1
—
—
—
0
0
40
40
10.40
35.58
1.2
1.1
1.14
1.05
ratio
1.05
35
33
344
1875
2.32
31.51
4.0
2.5
5.96
7.07
e6/l
0.67
314
1713
432
2622
2.20
30.12
2.7
2.1
185.03
207.68
u/l
0.17
412
2494
553
3761
2.15
28.09
6.1
4.7
35.29
35.81
g/l
1.30
530
3539
176
747
2.67
27.37
6.4
4.0
0.84
0.92
%
0.10
50
212
620
4449
2.17
26.85
6.0
4.0
0.00
0.00
estimate
0.50
162
902
624
4501
2.16
26.49
6.0
4.0
0.00
5.29
estimate
1.07
166
929
94
286
3.54
26.08
1.3
1.2
—
—
—
0
0
168
713
2.65
26.05
6.0
3.9
0.46
0.66
%
0.67
48
196
170
726
2.64
26.03
6.6
4.3
0.13
0.08
%
0.19
46
160
168
714
2.65
25.97
6.6
4.1
0.07
0.11
%
0.26
41
178
626
4540
2.14
25.93
6.0
4.0
0.00
0.35
estimate
0.53
163
887
804
6489
2.69
25.51
12.7
7.9
77.30
78.54
u/l
0.41
789
6126
137
532
2.85
25.18
1.8
1.8
1.32
1.48
g/l
0.43
126
490
523
3602
2.02
24.24
4.8
3.5
6.33
6.23
ph
1.27
292
1986
471
3144
2.00
23.65
6.2
3.8
124.87
114.84
e6/l
0.07
378
2174
376
2328
2.03
23.27
5.0
3.0
0.41
0.47
e6/l
0.23
313
1679
208
1023
2.33
23.26
1.5
1.4
—
—
—
0
0
34
48
7.31
23.02
1.1
1.1
—
—
—
0
0
421
2726
1.99
22.83
5.2
3.1
24.05
74.65
e6/l
1.29
359
2067
180
846
2.40
22.24
2.0
2.0
381.72
378.79
nmol/l
0.05
162
782
527
3742
1.93
21.23
19.7
10.7
0.00
0.00
e9/l
0.01
458
3040
239
1300
2.13
20.59
2.7
2.4
2.29
2.35
g/l
0.73
219
1204
35
58
6.23
20.42
1.9
1.3
4.79
6.95
u/l
0.92
30
48
278
1608
2.04
20.26
4.4
2.6
479.15
513.04
mosm/kgh2o
2.13
244
1405
179
872
2.30
20.23
2.0
1.5
—
—
—
0
0
136
594
2.51
19.59
2.1
2.7
—
—
—
0
0
205
1070
2.17
19.53
3.5
3.1
4.21
5.22
e9/l
0.71
185
919
28
14
20.57
19.14
1.3
1.2
—
—
—
0
0
550
4045
1.87
18.99
3.2
2.5
80.01
78.64
nmol/l
0.55
525
3633
246
1404
2.02
18.35
2.9
2.4
13.07
13.03
umol/l
0.03
231
1312
55
148
3.89
18.21
3.6
3.2
3.74
4.18
e9/l
0.69
55
148
151
714
2.33
18.18
2.3
3.1
67.29
67.39
g/l
0.06
141
660
347
2232
1.88
18.12
4.9
2.9
—
0.00
estimate
—
0
10
282
1702
1.94
17.83
1.5
1.3
40.52
33.11
iu/ml
0.48
106
546
217
1203
2.05
17.44
2.9
2.4
23.65
22.36
%
0.82
201
1128
392
2657
1.82
17.04
5.1
3.9
7.40
7.40
ph
0.12
294
1894
84
308
2.90
17.00
2.2
2.1
10.88
10.58
g/l
0.23
76
276
376
2520
1.82
16.94
6.0
4.1
0.00
0.01
estimate
1.15
159
858
59
182
3.39
15.97
3.8
3.1
59.51
57.75
%
0.44
59
182
287
1798
1.86
15.88
1.7
1.5
2.60
2.42
g/l
0.76
191
1081
26
19
14.04
15.56
1.0
1.1
—
—
—
0
0
24
37
6.63
14.98
1.0
1.0
—
—
—
0
0
174
937
2.05
14.94
3.4
2.6
1.74
1.83
%
0.65
162
840
563
4355
1.73
14.63
8.8
6.7
1.22
1.22
mmol/l
0.82
489
3754
460
3378
1.71
14.35
5.8
3.9
0.00
0.03
estimate
2.57
138
743
254
1589
1.82
13.82
1.4
1.3
13.10
13.44
u/ml
0.03
113
593
676
5555
1.78
13.69
6.3
4.8
1142.83
2421.24
e6/l
0.51
12
94
84
348
2.55
13.40
2.2
1.9
1.55
1.53
g/l
0.04
69
307
513
3926
1.68
13.33
7.6
5.9
1.22
1.21
mmol/l
0.95
494
3611
138
717
2.08
12.95
2.9
2.6
68.03
70.18
e9/l
0.30
100
531
420
3073
1.67
12.81
3.6
3.5
2.34
2.36
mmol/l
2.08
388
2782
195
1159
1.86
12.36
2.1
1.8
—
—
—
0
0
319
2194
1.69
12.18
5.4
4.0
—
—
—
0
0
564
4506
1.63
11.70
7.0
6.4
9.65
10.97
umol/l
2.91
547
4291
41
124
3.41
11.47
1.5
1.8
0.78
0.83
g/l
0.10
29
104
384
2807
1.62
11.36
3.9
3.2
—
—
—
0
0
184
1107
1.82
11.12
6.2
4.7
1.04
1.03
mmol/l
0.09
178
1011
336
2396
1.63
10.88
5.3
3.4
0.00
0.06
estimate
1.04
138
725
155
907
1.85
10.19
1.6
1.5
—
—
—
0
0
442
3404
1.57
10.12
2.3
2.1
—
—
—
0
0
482
3794
1.56
9.96
13.1
13.0
1.18
1.21
inr
0.71
400
3111
28
72
3.98
9.91
1.2
1.3
0.50
0.36
g/l
0.68
18
56
28
72
3.98
9.91
1.2
1.3
8.41
7.07
g/l
0.45
18
57
28
72
3.98
9.91
1.2
1.3
3.15
2.83
g/l
0.37
17
55
133
749
1.90
9.83
1.5
1.4
—
—
—
0
0
123
680
1.93
9.61
7.4
4.0
—
—
—
0
0
290
2046
1.60
9.57
1.4
1.3
2.88
1.42
u/ml
0.49
80
528
25
61
4.18
9.48
1.2
1.1
646.67
89.00
titre
—
9
10
19
22
8.79
9.32
1.5
1.1
—
—
—
0
0
256
1772
1.61
9.06
3.3
2.8
2.45
2.46
mmol/l
0.09
230
1598
348
2587
1.55
9.05
9.6
6.2
—
—
—
0
0
27
73
3.78
8.93
1.2
1.3
—
—
—
0
0
212
1424
1.63
8.40
3.7
3.0
0.81
0.82
mmol/l
0.40
197
1347
303
2213
1.55
8.40
2.8
2.2
2.94
2.89
mg/l
0.11
267
1897
870
8062
2.12
8.22
26.1
14.9
21.19
22.92
mg/l
0.85
768
6578
118
677
1.85
8.20
7.1
6.2
10.20
9.49
mmol/l
0.45
113
647
352
2690
1.49
7.75
2.9
2.5
59.26
63.60
u/l
0.58
329
2473
210
1434
1.60
7.72
4.3
2.8
0.81
1.14
e6/l
1.41
139
723
182
1206
1.63
7.55
1.6
1.6
—
—
—
0
0
493
4042
1.46
7.52
3.5
3.0
125.04
109.05
ug/l
1.41
462
3765
44
177
2.56
7.51
1.5
1.3
50.39
59.68
mmol/l
1.19
38
145
204
1393
1.59
7.48
1.6
1.8
—
—
—
0
0
51
224
2.35
7.23
1.5
1.2
80.00
94.80
titre
—
6
25
20
52
3.91
7.01
1.2
1.2
15.16
23.15
umol/l
0.78
20
46
364
2849
1.45
6.90
4.0
3.2
30.59
30.45
u/l
0.04
346
2697
79
421
1.96
6.87
2.7
2.0
0.00
0.01
estimate
0.50
30
117
17
29
5.95
6.63
1.1
1.0
—
—
—
0
0
17
29
5.95
6.63
1.1
1.0
—
—
—
0
0
17
29
5.95
6.63
1.1
1.0
—
—
—
0
0
744
6702
1.54
6.47
5.3
4.6
14.77
14.79
pmol/l
0.08
701
6136
218
1576
1.50
6.06
5.1
3.8
362.22
393.00
ng/l
0.09
176
1196
101
606
1.75
6.04
2.9
3.0
226.56
199.88
ng/l
0.19
91
559
328
2568
1.43
6.01
3.4
3.0
1154.60
1044.48
ng/l
0.28
294
2175
278
2119
1.44
5.87
4.8
3.7
94.93
92.82
%
0.79
271
2070
99
597
1.74
5.82
1.4
1.4
—
—
—
0
0
162
1111
1.55
5.73
2.7
2.3
161.88
117.17
ug/g
0.90
137
869
14
23
6.16
5.70
1.1
1.2
25.71
28.48
s
0.78
14
23
127
828
1.62
5.56
2.5
2.0
0.00
0.02
estimate
0.50
33
148
48
231
2.14
5.53
3.1
3.0
1.06
2.03
index
0.91
18
121
254
1926
1.44
5.46
1.9
1.7
0.99
1.15
mg/l
0.76
213
1489
262
1999
1.43
5.44
5.8
4.1
1.02
1.02
kg/l
0.18
193
1315
122
794
1.62
5.38
2.5
2.2
0.20
0.21
g/l
0.68
117
744
562
4881
1.38
5.33
5.7
4.7
6.29
6.61
mmol/l
4.91
545
4619
195
1412
1.48
5.32
2.0
1.7
1225.94
1187.78
nmol/l
0.24
154
1055
175
1243
1.50
5.24
1.4
1.2
—
—
—
0
0
55
285
1.99
5.22
2.2
4.2
33.95
62.29
mg/l
1.33
46
249
55
285
1.99
5.22
2.3
4.2
43.67
68.82
mg/l
0.61
45
249
112
720
1.63
5.19
1.2
1.2
—
—
—
0
0
336
2710
1.37
4.97
2.6
2.2
—
—
—
0
0
23
84
2.78
4.80
1.2
1.2
—
—
—
0
0
93
582
1.66
4.79
1.3
1.2
150.93
193.46
u/ml
0.34
86
537
9
10
9.07
4.79
1.3
1.3
—
—
—
0
0
9
10
9.07
4.79
1.1
1.2
—
—
—
0
0
107
698
1.60
4.68
5.0
3.6
1.23
1.23
mmol/l
0.02
98
594
260
2037
1.38
4.52
2.5
2.2
—
—
—
0
0
314
2537
1.36
4.50
1.9
1.7
20.49
20.79
nmol/l
0.13
268
2125
27
111
2.47
4.50
2.0
2.4
—
—
—
0
0
82
507
1.68
4.43
3.9
3.5
7.42
7.42
ph
0.12
74
422
179
1320
1.44
4.39
4.8
2.9
2.98
3.40
e6/l
0.28
109
610
19
66
2.92
4.35
1.6
1.5
—
—
—
0
0
98
640
1.59
4.27
2.8
2.4
4.98
7.50
ug/l
1.54
83
564
442
3807
1.31
3.92
2.3
2.1
98.08
96.25
pmol/l
0.35
239
1922
91
597
1.58
3.91
2.6
2.5
5.72
21.86
au/ml
—
6
63
377
3189
1.31
3.79
4.5
3.7
241.96
63.73
ng/l
0.47
282
2250
56
327
1.76
3.75
1.5
1.9
0.68
2.28
ug/l
1.02
51
290
30
142
2.15
3.68
1.4
1.3
114.40
157.33
au/ml
—
7
46
47
262
1.84
3.66
2.3
3.8
1.20
3.74
ratio
1.12
22
150
22
91
2.45
3.66
2.6
2.4
1.16
1.24
g/24h
0.05
13
60
106
731
1.51
3.65
4.9
3.3
80.70
79.21
ng/l
0.07
96
636
17
62
2.77
3.60
1.6
1.4
35.90
27.90
%
—
10
40
33
164
2.05
3.58
1.4
1.4
—
—
—
0
0
130
938
1.45
3.57
6.6
7.4
0.55
1.05
mmol/l
0.59
111
778
131
948
1.44
3.54
6.6
7.4
12.57
12.31
kpa
0.24
126
910
131
948
1.44
3.54
6.6
7.4
5.02
5.08
kpa
0.35
126
909
8
13
6.20
3.50
1.1
1.1
—
—
—
0
0
131
951
1.44
3.48
7.0
7.4
7.42
7.42
ph
0.31
64
524
260
2113
1.32
3.44
3.0
2.5
326.37
329.83
umol/l
0.21
234
1862
11
27
4.11
3.40
3.5
1.9
0.59
0.63
mmol/l
0.47
11
27
9
18
5.04
3.37
5.4
2.1
—
—
—
0
0
46
263
1.79
3.33
1.3
1.5
294.20
291.58
ug/g
0.02
23
154
25
115
2.21
3.31
2.3
1.7
0.94
0.87
%
0.26
17
75
22
96
2.32
3.28
1.8
1.6
56.77
61.12
%
0.16
13
67
85
573
1.53
3.27
2.8
3.5
4.32
4.59
pmol/l
1.92
73
510
13
43
3.05
3.26
1.0
1.0
1590.62
1688.53
miu/ml
0.10
13
43
36
192
1.91
3.24
2.4
2.1
131.04
128.96
g/l
0.23
26
154
13
39
3.37
3.23
1.8
1.6
68.81
51.07
ug/l
0.36
13
39
27
130
2.11
3.20
1.0
1.1
—
—
—
0
0
49
289
1.73
3.20
4.9
3.3
132.22
297.67
mg/l
2.01
23
111
450
3952
1.27
3.20
3.0
2.6
—
—
estimate
—
0
0
605
5506
1.28
3.20
3.9
3.3
53.29
46.40
u/l
1.13
577
5149
865
8302
1.55
3.20
25.9
17.8
3.94
3.96
mmol/l
0.80
857
8120
113
813
1.44
3.16
5.4
3.9
7.38
7.37
ph
0.94
97
571
33
173
1.94
3.13
4.3
3.6
61.47
2066.12
u/ml
0.77
26
163
132
979
1.41
3.12
2.9
2.6
7.11
7.17
umol/l
0.01
115
861
326
2760
1.28
3.11
4.7
3.3
57.40
44.28
mg/l
0.43
209
1659
816
7753
1.41
3.09
6.5
5.7
1.98
1.88
mu/l
0.47
767
7164
863
8287
1.53
3.08
25.6
17.6
138.81
139.68
mmol/l
13.24
856
8119
30
153
1.99
3.07
1.3
1.3
269.15
216.93
u/ml
0.50
21
87
22
101
2.21
2.95
1.4
1.4
270.15
275.21
mosm/kgh2o
0.40
13
78
10
27
3.73
2.88
2.6
2.0
28.80
32.30
%
—
10
27
109
797
1.42
2.81
7.3
8.1
117.19
119.48
g/l
0.70
109
777
16
65
2.49
2.80
1.1
1.2
—
—
—
0
0
31
166
1.90
2.79
1.2
1.2
—
—
—
0
0
20
91
2.22
2.75
1.2
1.2
—
—
—
0
0
47
287
1.67
2.75
1.9
1.8
20.53
20.71
s
0.12
34
259
21
98
2.17
2.72
1.3
1.6
35.31
28.31
ng/l
0.26
21
98
31
169
1.86
2.65
1.4
1.5
—
—
—
0
0
99
721
1.42
2.62
7.4
7.4
—
—
—
0
0
34
192
1.80
2.61
1.2
1.4
2.71
48.74
e6/l
0.85
28
144
9
25
3.62
2.58
1.1
1.2
—
—
—
0
0
335
2902
1.24
2.53
4.8
3.3
6.75
7.13
mmol/l
0.95
293
2435
38
225
1.72
2.50
1.4
1.4
420.00
535.52
mg/l
1.51
38
213
30
168
1.81
2.39
4.0
2.5
7.66
8.10
pmol/l
0.12
30
168
6
13
4.64
2.27
1.0
1.1
—
—
—
0
0
128
996
1.33
2.27
1.4
1.3
—
—
—
0
0
21
106
2.00
2.27
1.6
1.2
—
—
—
0
0
216
1804
1.26
2.23
1.8
1.8
64088866.91
25250939.84
pmol/l
0.26
181
1497
322
2809
1.22
2.22
5.7
4.0
12.23
8.35
mg/mmol
0.75
203
1648
138
1090
1.31
2.21
1.4
1.3
—
—
—
0
0
22
116
1.92
2.12
1.3
1.3
—
—
—
0
0
22
116
1.92
2.12
1.3
1.3
—
—
—
0
0
22
116
1.92
2.12
1.3
1.3
—
—
—
0
0
22
116
1.92
2.12
1.3
1.3
—
—
—
0
0
29
168
1.75
2.09
3.9
3.5
—
—
—
0
0
36
225
1.62
1.99
1.5
1.6
4374.93
13472.03
e6/l
1.38
27
159
13
57
2.30
1.98
1.0
1.1
—
8.68
—
0
18
11
45
2.46
1.93
1.0
1.3
142.36
142.21
nmol/l
0.00
11
45
396
3566
1.19
1.89
2.2
1.9
1.25
1.34
mmol/l
1.70
322
3014
26
151
1.74
1.88
4.0
3.7
2.56
2.82
mmol/l
0.23
20
106
8
29
2.77
1.79
1.4
1.3
10.61
61.59
u/l
—
8
29
46
314
1.49
1.77
1.4
1.6
8.95
12.20
u/ml
—
6
63
280
3154
0.84
1.67
3.3
3.2
—
—
—
0
0
8
31
2.59
1.66
1.0
1.1
12.38
6.71
mm/h
—
8
31
16
83
1.94
1.65
1.2
1.3
—
—
—
0
0
37
245
1.53
1.65
1.2
1.3
—
—
—
0
0
102
808
1.29
1.63
1.5
1.5
—
—
—
0
0
104
826
1.29
1.63
3.8
3.1
7.38
7.38
ph
0.08
64
456
12
56
2.16
1.61
1.2
1.0
—
—
—
0
0
14
70
2.02
1.59
1.1
1.3
—
—
—
0
0
8
33
2.44
1.54
1.1
1.2
84.61
140.02
iu/ml
—
8
33
8
33
2.44
1.54
1.0
2.4
40.45
41.35
g/l
—
8
33
50
362
1.40
1.45
4.5
3.6
—
—
—
0
0
91
723
1.29
1.44
1.5
1.7
—
—
—
0
0
6
22
2.74
1.43
1.2
1.1
—
—
—
0
0
6
22
2.74
1.43
2.2
2.4
0.00
0.00
estimate
—
6
22
22
135
1.64
1.36
1.0
1.0
—
—
—
0
0
81
641
1.29
1.34
1.3
1.2
140.39
142.18
u/ml
0.01
38
243
16
90
1.79
1.33
1.1
1.1
—
—
—
0
0
99
804
1.26
1.33
3.9
3.0
1.28
1.87
mmol/l
0.98
84
686
27
176
1.55
1.33
2.3
2.2
113.56
82.82
ug/min
0.18
14
98
9
43
2.10
1.30
1.1
1.2
—
—
—
0
0
53
699
0.74
1.30
1.2
1.4
—
—
—
0
0
19
114
1.68
1.29
1.7
2.6
—
—
—
0
0
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
5
18
2.79
1.28
1.0
1.0
—
—
—
0
0
39
277
1.43
1.28
4.4
3.8
24.31
24.95
mmol/l
0.78
39
257
892
8765
1.38
1.27
39.1
23.4
251.39
255.66
e9/l
1.21
887
8590
892
8769
1.37
1.23
39.0
23.4
4.33
4.44
e12/l
9.93
885
8566
892
8770
1.36
1.21
39.2
23.4
6.48
6.65
e9/l
1.68
886
8564
13
71
1.84
1.20
1.4
1.6
—
—
—
0
0
12
64
1.89
1.18
1.1
1.0
—
—
—
0
0
14
79
1.78
1.17
1.1
1.1
—
—
—
0
0
21
134
1.58
1.15
2.1
1.9
—
—
—
0
0
57
442
1.31
1.12
1.3
1.2
—
—
—
0
0
11
58
1.91
1.12
2.0
1.7
69.09
106.02
ng/l
1.46
11
58
10
51
1.97
1.11
1.2
1.3
—
—
—
0
0
101
844
1.22
1.08
3.9
3.0
5.82
5.77
kpa
0.14
95
820
16
98
1.64
1.03
1.4
2.2
—
—
—
0
0
11
60
1.84
1.03
1.5
2.0
16.34
19.23
nmol/l
0.49
11
55
92
768
1.22
1.00
6.4
6.4
1.14
1.31
mmol/l
1.22
92
752
30
214
1.42
1.00
1.7
1.7
—
—
—
0
0
9
49
1.84
0.98
1.2
1.0
—
—
—
0
0
7
37
1.90
0.94
1.0
1.1
—
—
—
0
0
49
619
0.78
0.93
1.2
1.8
3.13
3.44
mmol/l
0.97
31
445
51
402
1.28
0.92
2.2
1.9
—
—
—
0
0
18
118
1.54
0.91
1.4
1.3
—
—
nmol/l
—
0
0
42
323
1.31
0.91
6.4
5.7
0.86
0.93
%
0.56
42
302
83
694
1.22
0.91
3.1
2.5
6.36
6.09
ph
1.66
46
474
10
56
1.79
0.88
1.1
1.3
—
—
—
0
0
6
30
2.01
0.87
1.2
1.6
95.22
79.73
nmol/24h
—
6
30
23
162
1.43
0.85
1.4
1.5
—
—
—
0
0
13
80
1.63
0.85
2.8
2.9
15.33
11.65
index
—
6
48
9
151
0.59
0.79
1.3
1.3
—
—
—
0
0
14
90
1.56
0.78
1.4
1.2
—
—
—
0
0
12
74
1.63
0.78
1.1
1.1
99.67
111.92
pmol/l
0.50
12
74
33
253
1.32
0.76
1.7
2.7
—
—
—
0
0
18
124
1.46
0.75
1.4
1.3
0.18
0.34
nmol/l
0.53
13
95
14
91
1.55
0.75
1.1
1.4
—
—
—
0
0
11
67
1.65
0.75
1.3
1.1
—
—
—
0
0
94
812
1.18
0.75
2.7
2.4
46.03
40.87
u/l
0.21
80
674
5
24
2.09
0.74
2.2
2.4
5.48
9.41
mg/l
—
5
19
19
133
1.44
0.74
1.3
1.4
0.30
0.34
nmol/l
0.22
13
103
52
425
1.24
0.73
2.3
2.4
—
—
—
0
0
845
8311
1.17
0.73
20.3
13.7
—
—
—
0
0
41
327
1.27
0.71
1.4
1.6
0.44
0.34
mg/l
0.34
14
141
9
144
0.62
0.70
1.7
1.5
—
—
—
0
0
9
146
0.61
0.69
1.7
1.6
—
—
—
0
0
7
42
1.67
0.68
2.3
2.4
—
—
—
0
0
20
144
1.40
0.68
1.1
1.1
—
—
—
0
0
22
163
1.36
0.64
5.7
7.9
10.45
11.05
mmol/l
0.45
22
147
22
163
1.36
0.64
5.7
7.9
105.50
105.41
mmol/l
0.03
22
147
14
95
1.48
0.64
1.2
1.1
—
—
—
0
0
12
177
0.67
0.63
1.2
1.7
1.09
0.88
nmol/l
0.34
12
142
11
71
1.56
0.62
1.7
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
11
72
1.53
0.59
1.5
1.4
—
—
—
0
0
44
367
1.21
0.55
6.4
5.2
1.82
1.53
%
0.71
44
347
27
213
1.28
0.54
1.2
1.2
—
—
—
0
0
22
170
1.30
0.52
5.7
3.8
27.67
27.04
mg/l
0.03
15
113
6
40
1.50
0.51
2.3
3.0
883.83
686.33
u/ml
—
6
40
19
144
1.33
0.51
1.1
1.1
—
—
—
0
0
251
2364
1.08
0.50
1.5
1.5
—
—
—
0
0
37
443
0.83
0.50
1.5
1.7
—
—
—
0
0
7
107
0.65
0.49
1.0
1.1
—
—
—
0
0
38
319
1.20
0.46
1.0
1.1
—
—
—
0
0
16
120
1.34
0.46
1.3
1.2
—
—
—
0
0
19
243
0.78
0.46
1.1
1.1
—
—
—
0
0
29
237
1.23
0.45
1.2
1.2
—
—
—
0
0
781
7693
1.09
0.44
6.7
6.3
38.36
39.09
mmol/mol
1.90
729
7177
7
51
1.38
0.44
7.4
2.8
7.67
7.93
mmol/l
—
7
51
803
7920
1.10
0.44
5.4
5.2
5.69
5.90
mmol/l
5.69
744
7263
13
95
1.37
0.44
1.5
1.4
31.77
33.22
g/l
0.14
13
85
11
78
1.42
0.43
3.5
3.4
—
—
—
0
0
8
56
1.43
0.42
1.4
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
100
914
1.11
0.40
4.0
4.3
9.03
25.42
ug/l
0.99
84
749
0
18
0.00
0.40
0.0
1.1
—
57.97
—
0
18
155
1447
1.09
0.40
5.4
5.3
2.50
2.36
ug/l
0.07
140
1299
13
171
0.76
0.39
3.5
1.6
—
—
—
0
0
8
61
1.31
0.39
1.5
1.5
0.80
1.17
promille
—
8
50
5
35
1.43
0.39
1.4
2.7
—
—
—
0
0
19
236
0.80
0.38
2.5
1.4
—
—
—
0
0
18
143
1.26
0.37
1.3
1.4
—
—
—
0
0
777
7669
1.08
0.36
4.6
4.3
1.22
1.27
mmol/l
1.40
713
7016
32
274
1.17
0.34
3.0
2.2
14894.60
4619.99
u/l
—
8
119
23
191
1.21
0.33
3.0
1.8
—
—
—
0
0
6
46
1.31
0.33
1.2
1.7
—
—
—
0
0
12
92
1.31
0.32
1.4
2.5
5.04
5.89
umol/l
—
7
61
31
267
1.17
0.31
3.7
3.9
1.59
1.29
mmol/l
0.46
31
261
7
97
0.72
0.31
1.6
1.1
—
—
—
0
0
29
335
0.86
0.30
2.5
3.4
56.00
4261.59
u/ml
0.82
22
292
16
130
1.23
0.29
1.1
1.2
—
—
—
0
0
53
585
0.90
0.28
2.8
3.3
112.67
78.90
u/ml
0.15
53
564
22
256
0.86
0.25
2.6
1.4
—
—
—
0
0
22
256
0.86
0.25
1.0
1.2
1.56
1.58
g/l
0.19
22
256
23
266
0.86
0.25
1.3
1.2
0.84
0.91
g/l
0.65
23
266
808
8013
1.06
0.23
5.3
5.1
1.48
1.52
mmol/l
1.73
740
7412
5
38
1.32
0.23
1.4
1.6
—
—
—
0
0
85
797
1.07
0.22
1.4
1.4
—
—
—
0
0
81
864
0.93
0.22
3.3
3.1
0.56
0.74
ug/l
2.21
49
541
29
257
1.13
0.22
1.9
2.0
5.67
26.30
iu/l
0.46
13
106
0
10
0.00
0.21
0.0
1.1
—
0.14
—
0
5
0
12
0.00
0.21
0.0
1.1
—
41.40
—
0
5
0
12
0.00
0.21
0.0
1.2
—
1.36
—
0
5
5
43
1.16
0.21
9.4
3.0
14.40
16.46
%
—
5
43
11
89
1.24
0.21
1.9
2.3
—
—
—
0
0
75
703
1.07
0.20
3.2
2.6
4.46
4.46
kpa
0.00
70
680
6
48
1.25
0.20
2.8
3.2
0.33
0.88
index
—
6
48
15
176
0.85
0.20
3.8
1.7
66.20
60.51
%
0.49
15
176
10
81
1.24
0.19
3.7
1.7
10.58
10.57
%
—
10
81
22
248
0.88
0.18
12.3
9.3
—
—
—
0
0
31
284
1.09
0.15
1.2
1.3
—
—
—
0
0
810
8056
1.04
0.14
5.6
5.1
4.52
4.73
mmol/l
7.73
749
7491
21
189
1.11
0.14
6.4
3.7
—
—
—
0
0
23
253
0.91
0.13
2.5
1.4
—
—
—
0
0
13
113
1.15
0.13
1.2
1.0
3.02
1.43
eliau/ml
—
5
47
26
283
0.92
0.13
1.3
1.3
244.80
254.31
miu/ml
—
10
138
17
152
1.12
0.12
1.2
1.1
0.46
1.64
u/ml
—
8
76
24
258
0.93
0.09
2.5
1.4
—
—
—
0
0
6
56
1.07
0.08
1.3
1.6
12.60
11.65
umol/l
—
6
49
24
255
0.94
0.07
2.4
1.4
—
—
—
0
0
8
91
0.88
0.06
2.1
1.6
—
—
—
0
0
819
8174
1.02
0.04
6.2
5.9
2.60
2.75
mmol/l
5.59
757
7578
63
619
1.02
0.02
1.3
1.2
—
—
—
0
0
13
126
1.03
0.00
1.3
1.0
1.63
2.00
u/ml
—
7
48
16
164
0.98
0.00
1.8
1.8
43.62
43.12
nmol/l
0.02
16
155
40
396
1.01
0.00
1.1
1.1
—
—
—
0
0
11
108
1.02
0.00
3.6
1.4
—
—
—
0
0
12
118
1.02
0.00
4.4
5.6
406.23
363.38
umol/l
—
7
104
96
956
1.00
0.00
1.7
1.7
—
—
—
0
0
20
203
0.98
0.00
4.8
4.2
30.50
40.78
u/ml
0.29
20
197
13
129
1.01
0.00
1.2
1.0
2.84
3.24
u/ml
—
5
62
19
195
0.97
0.00
2.7
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
6.2
—
7.89
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
6
61
0.98
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
232.80
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
2.9
2.4
—
—
—
0
0
7
76
0.92
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
87.14
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
30.86
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.2
384.17
389.73
nmol/l
—
6
55
0
6
0.00
-0.00
0.0
1.5
—
326.83
—
0
6
0
8
0.00
-0.00
0.0
1.8
—
63.63
—
0
8

Mortality – FinRegistry

Association

Association between endpoint L12_LUPUS and mortality.

Females

Parameter HR [95% CI] p-value
L12_LUPUS 1.429 [1.27, 1.61] < 0.001
Birth year 0.993 [0.99, 1.0] 0.127

During the follow-up period (1.1.1998 — 31.12.2019), 690 out of 3420 females with L12_LUPUS died.

Males

Parameter HR [95% CI] p-value
L12_LUPUS 1.68 [1.43, 1.98] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 248 out of 1146 males with L12_LUPUS died.

Mortality risk

Mortality risk for people of age

years, who have L12_LUPUS.

N-year risk Females Males
1 0.121% 0.312%
5 0.794% 1.697%
10 2.072% 4.409%
15 3.835% 8.15%
20 6.609% 13.991%

Relationships between endpoints

Index endpoint: L12_LUPUS – Cutaneous lupus erythematosus

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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