Livedoid vasculitis

L12_LIVEDOIDVASC

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L95.0
  • Cause of death: ICD-10 L95.0

2 out of 7 registries used, show all original rules.

152

4. Check minimum number of events

None

152

5. Include endpoints

None

152

6. Filter based on genotype QC (FinnGen only)

138

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L95
Name in latin
Vasculitis lividoides

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 736 442 289
Only index persons 645 394 251
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 62.30 64.34 59.28
Only index persons 60.70 62.60 57.71

-FinnGen-

Key figures

All Female Male
Number of individuals 138 86 52
Unadjusted period prevalence (%) 0.03 0.03 0.02
Median age at first event (years) 64.10 66.01 60.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
146
Matched controls
1460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L95.0
ICD-10 Finland
Livedoid vasculitis
+∞
211.0
146
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
20.2
73.4
73
69
S97
ICPC
Chronic ulcer skin
19.8
65.2
61
51
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
124.7
62.4
64
9
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
25.0
55.5
43
24
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
720.9
53.0
49
*
L95.8
ICD-10 Finland
Other vasculitis limited to skin
+∞
37.1
34
*
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
63.5
33.5
38
8
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
11.9
29.1
33
35
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
93.5
28.0
30
*
A46
ICD-10 Finland
Erysipelas
6.9
27.5
58
128
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
6.4
21.8
45
95
SPAT1148
SPAT
Treatment of chronic ulcer or burn
5.9
21.0
49
116
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
8.1
21.0
32
49
D69.0
ICD-10 Finland
Allergic purpura
216.7
19.0
19
*
J01FF01
ATC
clindamycin; systemic
4.6
18.7
76
280
H02AB06
ATC
prednisolone; systemic
5.2
18.6
109
527
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.6
17.0
56
174
I83.2
ICD-10 Finland
Varicose veins of lower extremities with both ulcer and inflammation
95.6
15.9
17
*
L04AX01
ATC
azathioprine; systemic
13.0
15.8
28
26
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
178.3
15.8
16
*
D07AC01
ATC
betamethasone; topical
3.9
14.8
84
377
A08
ICPC
Swelling
6.4
14.6
27
50
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.9
14.2
37
94
J01MA02
ATC
ciprofloxacin; systemic
3.8
14.2
88
416
D07AD01
ATC
clobetasol; topical
4.2
14.0
48
151
E0000UV, ,
ATC
3.7
13.5
91
450
ZZA00
NOMESCO Finland
Split skin graft
21.6
13.3
19
10
J01CF05
ATC
flucloxacillin; systemic
5.4
12.2
27
59
H02AB07
ATC
prednisone; oral
4.2
12.1
39
116
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
21.1
11.9
17
9
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.9
11.7
29
70
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
11.4
38
116
N02AA05
ATC
oxycodone; systemic
3.5
11.2
52
198
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.2
11.1
81
406
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
23.7
10.9
15
7
L04AX03
ATC
methotrexate; systemic
4.5
10.9
30
79
S18
ICPC
Laceration/cut
3.3
10.9
97
545
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
10.7
99
566
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
25.6
10.5
14
6
B01AA03
ATC
warfarin; systemic
3.6
10.5
43
151
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
5.0
10.2
24
55
R60.0
ICD-10 Finland
Localized oedema
3.8
10.2
38
125
B01AB05
ATC
enoxaparin; parenteral
3.1
10.0
72
353
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.5
9.8
41
145
D07XC01
ATC
betamethasone; topical
4.0
9.7
32
96
S76
ICPC
Skin infection other
5.3
9.6
21
45
J04BA02
ATC
dapsone; oral
106.7
9.5
10
*
L04AD01
ATC
ciclosporin; systemic
17.0
9.2
14
9
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.9
9.2
22
51
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.5
9.1
19
39
D09AB01
ATC
zinc bandage without supplements; topical
20.2
9.1
13
7
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.9
9.1
31
95
TQW80
NOMESCO Finland
Local dermatologic skincare
12.7
8.8
15
13
S21
ICPC
Skin texture symptom/complaint
3.2
8.8
43
167
C03CA01
ATC
furosemide; systemic
2.9
8.8
67
334
P01BA02
ATC
hydroxychloroquine; oral
4.4
8.6
24
63
S91.0
ICD-10 Finland
Open wound of ankle
29.5
8.6
11
*
N02AX02
ATC
tramadol; systemic, rectal
2.8
8.5
86
493
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.8
8.5
29
89
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.8
8.2
28
86
D07AB08
ATC
desonide; topical
3.7
8.1
29
92
J01MA12
ATC
levofloxacin; systemic
3.1
8.0
42
169
D02AX
ATC
Other emollients and protectives
12.8
7.7
13
11
K07
ICPC
Swollen ankles/oedema
4.9
7.7
18
41
L28
ICPC
Limited function/disability (L)
2.9
7.6
45
193
C03DA01
ATC
spironolactone; oral
3.3
7.5
32
113
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
11.8
7.5
13
12
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.4
7.3
29
98
D07AC13
ATC
mometasone; topical
2.7
7.3
55
268
S11
ICPC
Skin infection post-traumatic
21.3
7.2
10
5
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
9.5
7.2
14
16
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
7.2
84
504
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
6.9
50
238
L89
ICD-10 Finland
Decubitus ulcer and pressure area
42.1
6.8
8
*
SPAT1229
SPAT
Assessment of need for aid
3.9
6.7
21
60
L03.9
ICD-10 Finland
Cellulitis, unspecified
13.1
6.7
11
9
J01DB01
ATC
cefalexin; oral
4.1
6.7
132
1018
TQW11
NOMESCO Finland
Vacuum treatment of wound
10.8
6.7
12
12
E000006, ,
ATC
4.1
6.6
19
51
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.9
6.6
21
61
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
6.5
73
424
M30.0
ICD-10 Finland
Polyarteritis nodosa
72.9
6.5
7
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.8
6.4
21
62
M05BB03
ATC
alendronic acid and colecalciferol; oral
11.8
6.4
11
10
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
28.0
6.3
8
*
I73.8
ICD-10 Finland
Other specified peripheral vascular diseases
+∞
6.3
6
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.5
6.2
23
74
XQ848
NOMESCO Finland
Dermatological photography
9.2
6.2
12
14
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.2
6.2
17
44
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
6.1
50
250
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
6.1
37
160
Z2221
NOMESCO Finland
Medical doctor
2.4
6.0
55
289

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
62
47
22.19
70.18
1.4
1.3
—
—
—
0
0
41
17
33.14
59.64
1.4
1.1
3.10
7.80
u/ml
—
21
5
55
54
15.74
52.71
1.5
1.2
—
—
—
0
0
67
143
7.81
33.54
4.5
1.5
—
—
—
0
0
43
60
9.74
31.10
1.9
1.5
14.30
15.36
iu/ml
—
7
11
39
15
34.92
30.35
1.2
1.1
—
—
—
0
0
35
15
30.21
26.33
2.5
1.7
—
—
—
0
0
65
190
5.36
22.01
1.8
1.4
726.96
636.73
titre
0.12
23
49
42
101
5.43
17.43
1.5
1.5
—
—
—
0
0
50
140
4.91
17.33
1.7
1.6
—
—
—
0
0
119
681
5.04
14.72
13.7
6.0
0.06
0.04
e9/l
0.73
106
572
40
106
4.82
14.62
2.6
3.3
—
—
—
0
0
118
677
4.87
14.39
13.8
6.0
0.70
0.58
e9/l
1.18
105
568
93
455
3.88
14.26
13.2
5.6
—
—
—
0
0
119
691
4.90
14.17
13.8
6.1
1.81
1.84
e9/l
0.13
107
604
56
199
3.94
13.78
3.1
1.9
31.22
29.00
s
1.51
56
194
120
710
4.88
13.70
14.0
6.0
0.20
0.18
e9/l
0.28
107
607
81
389
3.43
12.24
6.9
4.4
—
—
—
0
0
69
305
3.39
11.86
2.0
1.6
1.05
1.38
mg/l
0.79
60
244
121
769
4.35
11.33
18.3
9.8
4.91
4.24
e9/l
0.69
111
665
49
179
3.62
11.31
1.7
1.6
—
—
—
0
0
72
344
3.16
10.60
3.4
2.1
2.71
3.08
mg/l
0.68
67
293
52
207
3.35
10.38
3.2
2.1
—
—
—
0
0
112
709
3.49
9.81
9.5
7.8
1.21
1.21
mmol/l
0.04
99
612
43
163
3.32
9.17
1.8
1.6
—
—
—
0
0
20
29
7.81
8.91
1.5
1.1
—
—
—
0
0
103
646
3.02
8.67
8.9
7.1
1.21
1.21
mmol/l
0.01
95
598
49
208
3.04
8.57
1.9
1.9
—
—
—
0
0
36
129
3.38
8.34
2.6
3.5
67.85
69.39
e9/l
0.09
22
95
98
612
2.83
8.07
2.6
2.2
85.74
97.64
pmol/l
2.03
60
293
56
269
2.75
7.69
4.8
4.0
88.84
169.94
ng/l
0.32
50
219
109
736
2.90
7.44
9.1
6.4
11.14
11.50
umol/l
0.16
109
693
97
628
2.62
7.02
23.6
12.1
1.37
1.22
inr
1.47
82
514
85
526
2.47
6.65
6.9
4.6
45.02
120.74
e6/l
1.10
60
378
14
20
7.62
6.39
1.0
1.0
—
—
—
0
0
9
5
19.05
6.34
1.3
1.2
16.22
13.00
umol/l
—
9
5
13
19
7.39
5.88
1.2
1.4
240.88
441.67
u/ml
—
8
6
60
336
2.33
5.65
4.9
3.9
—
0.00
—
0
6
74
454
2.28
5.61
6.1
4.1
7.40
7.40
ph
0.17
55
319
80
509
2.26
5.53
2.9
2.1
—
—
—
0
0
69
413
2.27
5.53
9.6
6.5
—
—
—
0
0
76
474
2.26
5.51
5.3
3.6
24.80
46.08
e6/l
0.69
60
362
47
239
2.43
5.48
4.1
3.5
2.29
2.29
e6/l
0.00
24
116
12
18
7.16
5.38
1.6
1.2
—
—
—
0
0
71
437
2.22
5.25
4.0
2.3
—
—
—
0
0
70
430
2.21
5.18
1.9
1.8
20.34
21.80
nmol/l
0.32
59
350
78
502
2.19
5.12
5.3
3.2
2.36
2.36
mmol/l
0.05
73
444
13
24
5.84
5.05
1.1
1.0
—
—
—
0
0
59
355
2.11
4.46
3.7
2.9
348.48
345.44
umol/l
0.09
52
305
34
163
2.42
4.43
3.4
2.6
6.73
7.18
umol/l
0.11
28
143
66
416
2.07
4.40
5.3
3.4
0.39
0.46
e6/l
0.13
49
304
33
159
2.39
4.24
1.4
1.3
—
—
—
0
0
14
35
4.31
4.23
1.3
1.4
—
—
—
0
0
86
606
2.02
4.12
19.0
11.4
0.00
0.00
e9/l
0.71
72
476
29
137
2.39
3.88
7.3
7.3
—
—
—
0
0
83
591
1.94
3.72
4.5
3.5
6.24
6.21
ph
0.09
37
312
7
9
8.10
3.60
1.1
1.0
—
—
—
0
0
11
26
4.49
3.59
1.4
1.1
22.53
18.81
u/l
0.23
11
21
45
266
2.00
3.44
1.5
1.3
72.64
29.48
iu/ml
0.52
14
84
66
447
1.87
3.35
3.5
2.7
50.12
66.11
u/l
0.96
60
414
95
726
1.88
3.25
4.8
4.0
0.00
0.00
estimate
-0.00
14
150
12
35
3.64
3.19
2.1
1.9
56.17
55.25
%
0.04
12
35
13
41
3.38
3.15
1.2
1.8
—
—
—
0
0
26
463
0.47
3.15
2.7
3.4
—
—
—
0
0
95
730
1.86
3.15
4.8
4.0
0.00
10.55
estimate
0.50
14
154
5
5
10.29
3.00
2.4
1.2
—
—
—
0
0
30
160
2.10
2.99
3.8
3.2
7.39
7.39
ph
0.22
16
89
40
239
1.93
2.92
1.5
1.3
28.51
10.43
u/ml
0.60
21
84
133
1163
2.61
2.91
6.1
5.6
2.10
1.96
mu/l
0.60
122
1052
63
439
1.77
2.80
4.9
3.7
—
—
—
0
0
7
14
5.19
2.76
1.1
1.4
—
—
—
0
0
45
287
1.82
2.67
2.2
1.5
3.31
2.80
g/l
0.38
31
162
9
25
3.77
2.62
1.3
1.2
—
—
—
0
0
7
16
4.54
2.50
1.1
1.4
—
—
—
0
0
7
16
4.54
2.50
2.6
1.7
10.06
9.63
%
—
7
16
94
748
1.72
2.49
4.9
4.0
0.00
0.03
estimate
0.50
13
142
5
8
6.42
2.39
2.4
1.9
41.70
32.26
%
—
5
8
64
465
1.67
2.35
4.7
3.3
7.10
7.51
mmol/l
0.35
57
375
11
41
2.82
2.26
2.9
2.8
1.00
1.59
index
—
5
27
115
982
1.81
2.23
4.7
4.4
14.71
14.89
pmol/l
0.30
105
885
5
9
5.71
2.23
1.0
2.2
—
—
—
0
0
62
452
1.65
2.22
4.6
3.4
39.05
52.10
mg/l
0.38
45
284
56
404
1.63
2.06
4.2
3.2
—
0.17
—
0
12
18
91
2.12
2.06
2.0
2.7
1.31
1.20
%
0.21
18
91
18
91
2.12
2.06
8.1
7.1
25.08
24.58
mmol/l
0.19
18
91
20
106
2.03
2.03
2.0
2.4
7.89
6.71
ug/l
0.16
15
96
78
614
1.58
1.98
4.1
2.8
—
—
estimate
—
0
0
12
52
2.42
1.93
6.2
5.0
2.59
2.96
ratio
—
6
29
45
312
1.64
1.92
1.3
1.3
0.90
1.31
u/ml
—
10
85
7
23
3.14
1.82
1.1
1.4
—
—
—
0
0
20
111
1.93
1.79
1.1
1.3
—
—
—
0
0
61
462
1.55
1.78
5.6
4.1
7.51
9.10
mg/mmol
0.20
43
275
17
89
2.03
1.78
1.8
2.7
0.52
0.64
%
1.22
17
89
30
191
1.72
1.75
1.5
1.3
—
—
—
0
0
136
1252
2.26
1.74
40.3
16.8
28.30
22.78
mg/l
1.30
129
1032
27
167
1.76
1.74
8.6
10.4
0.39
0.85
mmol/l
0.22
21
143
32
208
1.69
1.73
6.2
6.7
103.16
103.92
mmol/l
0.33
32
208
6
19
3.25
1.68
1.3
1.2
—
—
—
0
0
16
84
2.02
1.67
1.3
1.3
—
—
—
0
0
41
288
1.59
1.64
3.8
3.1
523.18
505.02
mosm/kgh2o
0.26
34
255
14
71
2.07
1.60
2.7
2.4
—
—
—
0
0
10
44
2.36
1.59
4.0
2.2
1.58
1.72
mg/l
—
10
39
16
87
1.94
1.53
4.4
3.1
7.41
7.43
ph
0.47
16
70
6
21
2.93
1.52
1.2
1.0
—
—
—
0
0
26
166
1.69
1.50
9.0
10.5
7.39
7.41
ph
0.46
12
94
5
17
3.01
1.37
2.2
2.2
—
—
—
0
0
5
17
3.01
1.37
9.2
3.3
4.85
5.42
e9/l
—
5
17
0
41
0.00
1.33
0.0
5.5
—
—
—
0
0
8
35
2.36
1.29
9.9
18.8
2.10
1.34
mmol/l
—
8
29
129
1190
1.72
1.29
8.3
6.8
41.10
39.63
mmol/mol
0.96
122
1096
23
149
1.65
1.27
9.3
11.2
96.45
95.49
%
0.72
23
144
27
378
0.65
1.20
1.4
1.4
—
—
—
0
0
11
57
2.01
1.20
1.5
1.3
0.64
0.28
mg/l
—
5
24
8
39
2.11
1.17
1.3
1.2
—
—
—
0
0
11
58
1.97
1.15
1.0
1.1
—
—
—
0
0
18
112
1.69
1.15
1.4
1.4
—
—
—
0
0
14
81
1.81
1.13
13.0
13.6
14.61
15.57
%
0.64
14
76
24
165
1.54
1.05
1.5
1.3
—
—
—
0
0
9
51
1.81
0.96
1.2
1.1
—
—
—
0
0
16
103
1.62
0.92
5.8
4.2
0.60
0.35
%
—
10
30
10
56
1.84
0.90
5.2
3.3
—
—
—
0
0
19
131
1.52
0.83
1.5
1.5
—
—
—
0
0
8
133
0.58
0.78
1.6
1.7
—
—
—
0
0
22
160
1.44
0.76
3.8
3.4
5.44
5.92
e9/l
0.11
17
140
5
25
2.03
0.73
1.2
1.4
—
—
—
0
0
7
40
1.79
0.72
1.0
1.1
—
—
—
0
0
7
42
1.70
0.69
1.3
1.2
—
—
—
0
0
5
27
1.88
0.69
9.2
2.6
64.40
58.14
%
—
5
27
38
309
1.31
0.68
9.7
4.9
—
—
—
0
0
12
80
1.54
0.62
2.3
2.9
3.92
4.24
pmol/l
0.74
12
73
0
20
0.00
0.61
0.0
1.6
—
—
—
0
0
0
22
0.00
0.60
0.0
3.5
—
1.19
—
0
22
130
1244
1.41
0.59
6.6
5.4
6.40
6.00
mmol/l
0.51
122
1127
0
23
0.00
0.59
0.0
3.3
—
107.52
—
0
23
0
23
0.00
0.59
0.0
3.3
—
3.96
—
0
23
6
35
1.74
0.58
3.0
1.3
—
—
—
0
0
27
215
1.31
0.56
2.6
2.9
0.53
0.75
ug/l
2.04
21
128
6
38
1.60
0.55
3.0
1.3
—
—
—
0
0
6
38
1.60
0.55
3.0
1.3
—
—
—
0
0
37
309
1.26
0.54
4.1
3.9
1.02
1.02
kg/l
0.44
28
195
33
395
0.79
0.54
3.1
3.5
0.00
0.00
estimate
-0.00
11
119
132
1271
1.40
0.52
6.3
6.2
2.41
2.66
mmol/l
2.82
123
1161
9
65
1.41
0.51
1.7
4.7
36.64
36.93
°c
—
9
65
35
293
1.26
0.50
1.9
1.8
456.17
474.27
pmol/l
0.07
30
241
12
85
1.45
0.48
6.8
9.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
5
34
1.49
0.41
1.0
2.2
—
3.31
—
0
16
0
18
0.00
0.40
0.0
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.5
—
1.24
—
0
11
5
35
1.44
0.39
3.4
1.3
—
—
—
0
0
125
1287
0.80
0.35
20.9
14.7
—
—
—
0
0
6
88
0.67
0.34
1.2
1.4
—
—
—
0
0
8
66
1.22
0.27
1.4
2.2
—
—
—
0
0
9
72
1.27
0.26
1.0
1.2
—
—
—
0
0
44
401
1.14
0.26
4.9
4.0
0.00
0.00
estimate
-0.00
13
139
5
37
1.36
0.24
3.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
5.19
—
0
10
0
10
0.00
0.21
0.0
7.8
—
7.71
—
0
10
14
117
1.22
0.21
7.6
4.3
0.00
0.03
%
—
6
32
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
9
114
0.78
0.21
6.6
3.4
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
6
50
1.21
0.20
2.7
3.5
—
—
—
0
0
7
58
1.22
0.18
10.3
12.8
1.33
0.92
%
—
7
50
11
92
1.21
0.16
8.4
12.5
23.25
24.92
mmol/l
0.99
11
86
18
159
1.15
0.16
4.7
4.4
2.46
36.99
ug/l
0.72
12
133
58
554
1.08
0.13
2.0
2.0
1.44
1.35
mmol/l
0.34
47
454
10
116
0.85
0.12
1.5
1.4
—
—
—
0
0
52
539
0.95
0.08
4.1
3.9
0.00
0.00
estimate
—
10
126
13
117
1.12
0.08
8.2
4.0
0.57
0.67
%
—
7
39
53
548
0.95
0.08
5.4
4.1
32.76
44.80
ng/l
0.49
42
415
9
83
1.09
0.07
2.4
1.8
—
—
—
0
0
123
1242
0.94
0.05
5.5
5.4
1.36
1.50
mmol/l
3.96
116
1131
124
1248
0.96
0.02
5.7
5.4
4.32
4.61
mmol/l
3.09
118
1144
11
107
1.03
0.00
8.8
4.1
0.00
0.07
%
—
5
29
119
1195
0.98
0.00
4.7
4.6
1.30
1.26
mmol/l
0.25
113
1084
0
7
0.00
0.00
0.0
1.0
—
7.50
—
0
7
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
244.60
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
57.60
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
18.1
—
968.43
—
0
7
0
5
0.00
0.00
0.0
1.0
—
35.30
—
0
5
0
7
0.00
0.00
0.0
1.7
—
53.71
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
155.00
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
61
0.98
-0.00
11.2
12.3
1.75
1.57
%
—
6
54
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.2
—
60.00
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_LIVEDOIDVASC and mortality.

Females

Parameter HR [95% CI] p-value
L12_LIVEDOIDVASC 2.31 [1.71, 3.12] < 0.001
Birth year 0.992 [0.98, 1.0] 0.057

During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 387 females with L12_LIVEDOIDVASC died.

Males

Parameter HR [95% CI] p-value
L12_LIVEDOIDVASC 2.531 [1.81, 3.53] < 0.001
Birth year 0.988 [0.98, 1.0] 0.037

During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 258 males with L12_LIVEDOIDVASC died.

Mortality risk

Mortality risk for people of age

years, who have L12_LIVEDOIDVASC.

N-year risk Females Males
1 0.23% 0.457%
5 1.255% 2.884%
10 3.34% 7.557%
15 5.871% 13.411%
20 10.136% 22.15%

Relationships between endpoints

Index endpoint: L12_LIVEDOIDVASC – Livedoid vasculitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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