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Lichen planopilaris

DOID EFO Endpoint Browser PheWeb

L12_LICHENPLANO

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L66.1
  • Cause of death: ICD-10 — L66.1

2 out of 7 registries used, show all original rules.

151

4. Check minimum number of events

None

151

5. Include endpoints

None

151

6. Filter based on genotype QC (FinnGen only)

132

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L66
Name in latin
Lichen planopilaris

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 618 485 131
Only index persons 608 481 127
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.02 0.02 0.00
Median age at first event (years)
Whole population 59.19 61.81 49.78
Only index persons 59.08 61.54 49.78

-FinnGen-

Key figures

All Female Male
Number of individuals 132 116 16
Unadjusted period prevalence (%) 0.04 0.04 0.01
Median age at first event (years) 62.86 64.03 54.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
138
Matched controls
1380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L66.1
ICD-10 Finland
Lichen planopilaris
+∞
199.4
138
*
D07AD01
ATC
clobetasol; topical
28.3
84.4
109
162
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
23.0
73.0
66
53
P01BA02
ATC
hydroxychloroquine; oral
19.1
69.6
75
81
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.3
20.8
63
188
D07AC01
ATC
betamethasone; topical
5.3
20.5
92
376
D07AC13
ATC
mometasone; topical
4.9
19.6
76
275
L43.8
ICD-10 Finland
Other lichen planus
43.2
18.2
22
6
D07XC01
ATC
betamethasone; topical
5.9
17.7
39
87
L66.9
ICD-10 Finland
Cicatricial alopecia, unspecified
+∞
14.8
14
*
L43.9
ICD-10 Finland
Lichen planus, unspecified
17.4
13.6
21
14
E0000UV, ,
ATC
3.6
12.1
89
460
D05BB02
ATC
acitretin; oral
18.6
12.0
18
11
L66.8
ICD-10 Finland
Other cicatricial alopecia
+∞
11.6
11
*
J01AA04
ATC
lymecycline; systemic
4.5
11.5
33
90
D07AB02
ATC
hydrocortisone butyrate; topical
3.4
11.5
68
305
L63.9
ICD-10 Finland
Alopecia areata, unspecified
+∞
8.4
8
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
7.8
34
123
Z2221
NOMESCO Finland
Medical doctor
2.7
7.0
54
266
XQ848
NOMESCO Finland
Dermatological photography
8.5
6.8
14
18
L93.0
ICD-10 Finland
Discoid lupus erythematosus
28.1
6.3
8
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
50
16.08
50.52
1.4
1.2
—
—
—
0
0
56
194
4.18
14.52
1.4
1.5
364.44
726.67
titre
1.49
18
54
29
65
5.38
12.84
1.4
2.0
3.17
7.42
iu/ml
—
6
16
104
643
3.51
9.68
7.5
5.9
0.53
0.54
e9/l
0.17
88
551
104
649
3.45
9.41
7.5
5.9
0.04
0.04
e9/l
0.04
88
557
110
715
3.65
9.20
9.5
9.8
3.26
3.88
e9/l
3.25
94
626
105
665
3.42
9.14
7.6
6.0
0.18
0.18
e9/l
0.09
90
578
104
656
3.38
9.09
7.5
5.9
1.92
2.16
e9/l
0.62
88
583
40
158
3.16
7.92
1.6
1.4
—
—
—
0
0
71
404
2.56
6.84
7.3
5.7
—
—
—
0
0
91
593
2.57
6.43
8.1
6.0
53.42
56.25
%
2.25
91
565
81
531
2.27
5.22
2.9
2.1
—
—
—
0
0
35
160
2.59
5.12
1.7
1.2
—
—
—
0
0
84
569
2.22
4.87
11.3
10.6
0.00
0.00
e9/l
0.50
65
461
56
349
2.02
3.79
1.4
1.2
0.67
1.77
u/ml
—
10
95
78
566
1.87
3.21
2.1
2.0
103.81
98.86
pmol/l
0.37
27
265
5
5
10.30
3.00
1.0
1.2
—
—
—
0
0
12
44
2.89
2.62
1.5
1.3
46.62
30.51
iu/l
0.58
12
39
75
561
1.74
2.60
3.9
4.2
36.77
36.19
g/l
0.46
66
532
52
352
1.77
2.55
1.7
1.6
22.16
21.36
nmol/l
0.15
44
294
114
969
2.01
2.53
6.9
8.0
74.79
78.94
u/l
0.52
107
909
45
297
1.76
2.38
1.6
1.4
2.75
2.26
g/l
0.34
25
166
119
1038
2.06
2.28
5.4
4.7
14.32
14.79
pmol/l
1.63
112
953
64
472
1.66
2.24
2.5
2.9
2.35
2.37
mmol/l
0.32
58
431
16
79
2.16
1.94
2.2
1.7
—
—
—
0
0
43
295
1.66
1.94
2.2
2.1
1.94
2.94
mg/l
3.20
33
255
129
1185
2.36
1.91
7.0
5.9
1.85
1.88
mu/l
0.12
123
1096
29
182
1.75
1.79
2.4
3.1
6.31
3.17
e6/l
0.33
11
82
16
84
2.02
1.68
2.3
3.5
—
—
—
0
0
7
25
2.89
1.67
2.4
1.7
5.16
6.10
pmol/l
—
7
25
74
594
1.53
1.67
4.9
5.5
1.22
1.22
mmol/l
0.44
67
540
5
14
3.66
1.63
1.2
1.0
—
—
—
0
0
39
274
1.59
1.57
1.3
1.3
1.16
11.80
u/ml
2.18
13
102
54
411
1.52
1.53
2.8
3.5
7.40
7.40
ph
0.00
33
278
6
21
2.94
1.52
1.3
1.6
9.22
8.13
kpa
—
6
21
46
339
1.54
1.51
3.2
3.1
0.26
0.43
e6/l
0.54
29
241
41
295
1.55
1.49
1.4
1.3
12.65
37.20
iu/ml
2.39
13
98
5
16
3.20
1.45
1.6
1.6
—
—
—
0
0
79
656
1.48
1.43
5.8
6.4
1.22
1.22
mmol/l
0.21
67
572
20
121
1.76
1.40
1.3
1.2
—
—
—
0
0
5
17
3.01
1.37
3.6
3.8
—
19.02
—
0
6
74
612
1.45
1.34
2.1
1.9
1.30
1.33
mmol/l
0.14
65
508
6
25
2.46
1.25
1.7
1.3
—
—
—
0
0
12
65
1.93
1.17
2.2
1.8
—
—
—
0
0
13
75
1.81
1.07
2.6
2.5
—
—
—
0
0
9
46
2.02
1.06
1.1
1.1
—
—
—
0
0
131
1249
1.96
1.05
11.4
12.5
—
—
—
0
0
102
919
1.42
1.01
3.7
3.9
—
0.20
—
0
5
38
291
1.42
1.00
5.2
4.6
—
—
—
0
0
49
393
1.38
0.99
3.6
3.1
13.03
42.07
e6/l
1.17
32
298
0
28
0.00
0.99
0.0
3.0
—
56.10
—
0
28
5
104
0.46
0.93
1.8
2.3
7.60
4.15
kpa
—
5
104
6
30
2.04
0.88
1.3
1.0
—
—
—
0
0
50
411
1.34
0.85
5.4
6.4
—
—
—
0
0
112
1038
1.42
0.83
20.0
17.8
13.24
13.61
%
3.97
112
1029
8
48
1.71
0.80
1.1
1.1
—
—
—
0
0
6
33
1.85
0.80
1.3
2.8
—
—
—
0
0
0
25
0.00
0.80
0.0
2.6
—
54.95
—
0
25
34
266
1.37
0.79
3.2
2.4
6.98
5.92
e6/l
0.18
28
245
40
487
0.75
0.78
3.3
3.5
24.54
23.87
ng/l
0.03
27
333
18
125
1.51
0.77
1.7
1.6
—
—
—
0
0
17
117
1.52
0.76
1.3
1.4
—
—
—
0
0
19
135
1.47
0.74
1.5
1.6
—
—
—
0
0
40
326
1.32
0.71
2.5
3.6
—
0.00
—
0
5
7
120
0.56
0.71
3.9
2.7
5.73
5.78
kpa
—
7
120
46
384
1.30
0.69
1.9
3.0
—
0.20
—
0
10
22
164
1.41
0.68
2.1
1.8
155.53
114.14
ug/g
0.43
15
134
127
1216
1.56
0.66
13.3
14.1
18.72
21.28
mg/l
0.50
105
963
7
44
1.62
0.66
1.1
1.4
—
0.27
—
0
13
25
193
1.36
0.63
1.6
1.2
—
—
—
0
0
0
20
0.00
0.61
0.0
1.3
—
—
—
0
0
46
391
1.26
0.59
2.0
2.2
—
—
—
0
0
6
35
1.75
0.58
1.0
1.1
—
—
—
0
0
54
469
1.25
0.58
2.9
3.3
—
—
—
0
0
6
36
1.70
0.57
1.5
2.0
24.75
26.01
mmol/l
—
6
36
30
243
1.30
0.56
4.3
3.8
17.00
177.47
ng/l
1.36
21
186
10
66
1.56
0.54
2.6
2.2
—
—
—
0
0
35
291
1.27
0.54
1.9
1.6
0.87
1.15
mg/l
0.45
24
240
123
1179
1.40
0.54
4.9
4.3
1.19
1.24
mmol/l
0.50
114
1082
9
64
1.43
0.52
1.6
1.8
—
—
—
0
0
128
1236
1.49
0.52
5.7
5.2
1.58
1.58
mmol/l
0.01
121
1142
53
465
1.23
0.51
4.2
3.7
21.79
68.40
e6/l
1.74
33
312
123
1181
1.38
0.51
5.8
6.4
38.18
38.73
mmol/mol
0.40
118
1109
37
312
1.25
0.51
2.4
2.6
315.33
328.55
umol/l
0.30
30
267
127
1228
1.43
0.47
5.6
5.2
5.72
5.86
mmol/l
0.72
119
1133
12
86
1.43
0.46
1.3
1.4
—
—
—
0
0
61
548
1.20
0.46
2.5
3.3
6.12
6.18
ph
0.18
30
288
6
92
0.64
0.44
2.7
3.1
—
—
—
0
0
5
31
1.64
0.43
1.0
1.2
—
0.56
—
0
5
17
132
1.33
0.43
1.9
1.6
—
—
—
0
0
5
32
1.58
0.42
1.2
1.2
—
—
—
0
0
21
169
1.29
0.42
1.4
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
313.27
—
0
11
5
34
1.49
0.41
1.0
1.2
1.50
1.62
g/l
—
5
34
77
712
1.18
0.40
4.5
6.4
9.47
10.47
umol/l
0.74
71
679
10
71
1.44
0.40
7.3
7.2
24.77
24.72
mmol/l
—
10
71
0
19
0.00
0.39
0.0
1.5
—
1.20
—
0
19
0
19
0.00
0.39
0.0
1.5
—
108.05
—
0
19
0
19
0.00
0.39
0.0
1.5
—
3.87
—
0
19
16
201
0.77
0.39
1.4
1.6
559.06
1206.97
nmol/l
—
10
153
68
736
0.85
0.39
5.0
4.5
6.63
6.55
mmol/l
0.09
63
691
128
1245
1.39
0.38
6.2
5.3
4.67
4.80
mmol/l
0.91
122
1161
129
1258
1.39
0.37
6.7
6.2
2.74
2.78
mmol/l
0.19
123
1167
14
109
1.32
0.35
2.5
4.3
7.37
7.37
ph
—
9
67
88
829
1.17
0.35
4.2
4.2
—
6462.36
—
0
14
26
303
0.83
0.34
4.8
4.0
—
—
—
0
0
74
689
1.16
0.34
3.5
3.6
0.00
0.00
estimate
-0.00
18
128
15
121
1.27
0.30
1.3
1.5
—
—
—
0
0
45
408
1.15
0.29
2.9
2.4
53.85
66.16
u/l
0.57
40
378
74
696
1.14
0.27
3.5
3.6
0.00
0.00
estimate
-0.00
18
130
28
316
0.86
0.26
2.6
3.5
1.02
1.02
kg/l
0.03
19
193
13
106
1.25
0.24
1.5
1.5
—
—
—
0
0
5
37
1.36
0.24
1.0
1.3
—
—
—
0
0
5
37
1.36
0.24
1.8
1.4
—
—
—
0
0
5
37
1.36
0.24
1.0
1.3
0.98
0.87
g/l
—
5
37
7
93
0.74
0.23
1.1
1.3
—
—
—
0
0
19
163
1.19
0.23
10.4
6.9
105.05
104.07
mmol/l
0.61
19
163
12
98
1.25
0.22
14.4
8.1
—
—
—
0
0
74
703
1.11
0.22
3.5
3.7
0.00
0.00
estimate
-0.00
18
123
0
11
0.00
0.21
0.0
4.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
33.15
—
0
13
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
2.5
—
10.32
—
0
14
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
35
380
0.89
0.18
4.7
3.5
0.00
0.00
estimate
-0.00
18
116
5
69
0.71
0.17
2.0
4.5
—
—
—
0
0
8
70
1.15
0.16
17.9
9.3
25.75
24.50
mmol/l
—
8
70
43
402
1.10
0.16
3.0
2.8
—
—
—
0
0
24
217
1.13
0.16
3.3
2.6
531.74
505.35
mosm/kgh2o
0.29
19
192
59
561
1.09
0.16
16.7
9.8
1.20
1.15
inr
0.29
47
451
9
78
1.16
0.16
17.3
9.1
95.82
94.32
%
—
9
78
9
79
1.15
0.15
17.3
8.9
0.52
0.62
%
—
9
79
9
81
1.12
0.15
17.3
8.8
1.11
1.19
%
—
9
81
46
436
1.08
0.13
3.7
3.2
31.84
42.70
mg/l
0.19
26
251
17
152
1.14
0.13
1.2
1.3
—
—
—
0
0
12
104
1.17
0.13
1.2
1.4
—
—
—
0
0
48
456
1.08
0.13
3.5
3.1
6.25
7.18
mmol/l
0.74
38
379
26
242
1.09
0.10
1.7
1.7
502.90
488.82
pmol/l
0.07
21
206
50
521
0.94
0.10
3.4
3.4
0.00
0.00
estimate
-0.00
16
103
16
145
1.12
0.10
4.9
4.2
0.96
1.05
mmol/l
0.77
16
129
46
441
1.06
0.09
3.9
3.7
10.28
8.12
mg/mmol
0.10
25
242
6
55
1.09
0.09
1.5
1.4
—
—
—
0
0
16
174
0.91
0.08
1.3
1.9
—
—
—
0
0
13
118
1.11
0.07
2.2
4.9
3.70
2.00
ug/l
0.35
13
103
16
148
1.09
0.06
3.3
4.6
5.57
9.66
ug/l
—
9
117
59
605
0.96
0.06
2.5
2.6
—
—
estimate
—
0
0
35
362
0.96
0.04
1.3
1.4
—
—
—
0
0
20
192
1.05
0.02
2.7
1.8
—
—
—
0
0
38
373
1.03
0.01
3.1
3.0
1.47
0.00
estimate
0.48
17
98
14
142
0.98
0.00
11.3
7.7
7.43
7.42
ph
—
6
86
5
59
0.84
0.00
1.0
1.2
—
—
—
0
0
5
53
0.94
0.00
1.6
1.6
—
5.02
—
0
10
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
9.32
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
1334.17
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
34.36
—
0
7
0
7
0.00
-0.00
0.0
2.0
—
115.14
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.90
-0.00
1.6
2.6
4.39
4.77
ug/l
—
8
77
0
6
0.00
-0.00
0.0
27.2
—
923.33
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
28.60
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
238.41
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
6.44
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
27.60
—
0
6
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
64
0.93
-0.00
3.7
3.1
23.73
24.77
mmol/l
—
6
64
0
6
0.00
-0.00
0.0
1.8
—
8.95
—
0
6
0
9
0.00
-0.00
0.0
12.1
—
0.65
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
52.33
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
93
0.97
-0.00
1.7
2.1
3.08
3.41
mmol/l
—
9
71
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_LICHENPLANO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_LICHENPLANO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: L12_LICHENPLANO – Lichen planopilaris

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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