androgenetic alopecia:
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
115 |
4. Check minimum number of eventsNone |
115 |
5. Include endpointsNone |
115 |
6. Filter based on genotype QC (FinnGen only) |
105 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified cicatricial alopecia
based on the number of shared cases.
Similar with more cases:
- Cicatricial alopecia [scarring hair loss]
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 559 | 452 | 105 |
| Only index persons | 544 | 440 | 104 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.02 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 53.97 | 58.53 | 34.66 |
| Only index persons | 54.40 | 58.89 | 35.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 105 | 96 | 9 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.00 |
| Median age at first event (years) | 61.51 | 62.27 | 53.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 106
- Matched controls
- 1060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L66.9
ICD-10 Finland
Cicatricial alopecia, unspecified
+∞
86.7
71
*
L66.8
ICD-10 Finland
Other cicatricial alopecia
+∞
52.5
46
*
D07AD01
ATC
clobetasol; topical
15.9
47.7
71
120
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
13.1
33.8
40
47
D07AC01
ATC
betamethasone; topical
7.2
21.3
76
276
P01BA02
ATC
hydroxychloroquine; oral
7.7
21.0
38
72
L66.1
ICD-10 Finland
Lichen planopilaris
+∞
18.2
17
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.6
16.9
48
137
D07XC01
ATC
betamethasone; topical
6.2
13.8
28
58
L63.9
ICD-10 Finland
Alopecia areata, unspecified
134.0
11.7
12
*
D07AC13
ATC
mometasone; topical
3.6
9.4
50
212
J01AA04
ATC
lymecycline; systemic
4.7
9.0
24
62
XQ845
NOMESCO Finland
Dermatoscopy
15.1
7.1
11
8
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
42.9
6.9
8
*
XQ848
NOMESCO Finland
Dermatological photography
11.1
6.7
12
12
D06BX01
ATC
metronidazole; topical
3.8
6.4
22
68
L71.8
ICD-10 Finland
Other rosacea
28.5
6.3
8
*
L66.2
ICD-10 Finland
Folliculitis decalvans
+∞
6.3
6
*
E000001, ,
ATC
3.0
6.0
34
144
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
21
35
7.24
12.67
1.3
1.2
2.70
1.40
u/ml
—
8
7
23
45
6.25
11.88
3.4
1.8
19.06
6.63
iu/ml
0.78
13
12
14
34
4.58
4.40
1.2
1.2
—
—
—
0
0
13
32
4.48
4.07
3.2
1.5
0.21
0.22
g/l
0.08
13
32
96
783
3.40
3.64
5.7
4.9
14.49
15.00
pmol/l
1.51
84
704
66
468
2.09
3.28
2.7
2.5
83.32
80.64
nmol/l
0.31
54
422
92
752
2.69
3.12
7.9
8.1
72.45
79.05
u/l
1.37
87
703
76
577
2.12
3.03
8.9
10.2
3.64
3.83
e9/l
0.44
69
500
92
756
2.64
3.01
5.7
4.6
11.06
12.12
mm/h
0.44
87
687
39
243
1.96
2.66
1.6
1.8
0.60
1.21
mg/l
1.53
33
199
34
203
1.99
2.61
1.5
1.4
—
—
—
0
0
5
8
6.49
2.40
1.4
1.1
—
—
—
0
0
39
257
1.82
2.18
1.6
1.3
0.47
2.17
u/ml
0.92
12
60
12
52
2.47
1.96
1.4
1.4
—
—
—
0
0
9
34
2.80
1.91
1.1
1.4
—
—
—
0
0
8
28
3.00
1.90
1.5
1.5
—
—
—
0
0
43
305
1.69
1.81
2.6
2.5
59.37
53.94
u/l
0.46
38
276
49
362
1.66
1.76
2.4
3.1
2.37
2.36
mmol/l
0.22
42
333
47
346
1.64
1.69
3.9
3.4
—
—
—
0
0
99
908
2.37
1.59
18.5
15.6
79.92
80.37
ml/min/173m2
0.08
91
830
6
21
2.96
1.53
1.0
1.5
—
—
—
0
0
5
16
3.23
1.45
1.0
1.7
—
—
—
0
0
53
417
1.54
1.37
6.6
4.0
0.00
0.01
estimate
0.49
13
86
5
17
3.03
1.37
1.6
1.2
—
—
nmol/l
—
0
0
67
557
1.55
1.34
6.5
4.2
0.00
0.00
estimate
-0.00
14
105
18
108
1.80
1.33
11.2
6.8
—
—
—
0
0
5
18
2.86
1.30
1.0
1.8
—
—
—
0
0
67
560
1.53
1.28
6.5
4.3
0.00
14.76
estimate
0.50
17
110
67
566
1.50
1.17
6.4
4.3
0.00
0.00
estimate
-0.00
17
106
38
286
1.51
1.17
3.8
3.4
0.39
0.47
e6/l
0.10
28
190
5
20
2.57
1.16
1.4
1.3
—
—
—
0
0
20
129
1.68
1.16
7.7
6.5
106.00
104.16
mmol/l
1.99
20
129
10
51
2.06
1.15
2.2
3.0
67.68
46.49
%
—
10
51
8
40
2.08
1.15
1.9
1.5
—
—
—
0
0
98
918
1.89
1.02
7.3
5.9
1.83
1.89
mu/l
0.21
88
839
38
294
1.46
1.01
9.0
4.3
0.00
0.00
estimate
-0.00
13
102
29
214
1.49
0.97
1.2
1.4
7.61
9.64
u/ml
0.14
14
85
99
932
1.94
0.96
5.9
5.3
5.71
5.85
mmol/l
0.88
94
860
28
208
1.47
0.90
1.9
1.8
457.18
492.10
pmol/l
0.18
22
172
100
949
1.95
0.89
6.8
6.0
2.79
2.76
mmol/l
0.12
94
873
72
638
1.40
0.83
3.2
3.1
44.90
40.95
u/l
0.26
66
604
0
24
0.00
0.80
0.0
6.1
—
4.95
—
0
12
12
75
1.68
0.79
1.8
2.4
0.08
1.42
e6/l
0.57
12
69
52
441
1.35
0.77
4.5
4.2
35.41
36.00
g/l
0.29
45
418
9
55
1.69
0.76
1.7
2.4
0.78
1.30
%
—
9
55
99
942
1.77
0.73
6.1
5.2
4.81
4.80
mmol/l
0.07
94
872
7
42
1.71
0.70
2.1
2.4
24.91
24.76
mmol/l
—
7
42
68
609
1.33
0.66
2.9
3.1
—
—
—
0
0
23
175
1.40
0.65
3.0
3.1
1.08
0.92
e6/l
0.22
15
81
30
239
1.36
0.65
1.4
1.4
17.27
34.76
iu/ml
—
8
79
5
29
1.76
0.64
1.4
1.2
—
—
—
0
0
58
510
1.30
0.63
7.5
6.5
1.21
1.22
mmol/l
0.85
48
433
53
465
1.28
0.57
6.9
5.6
1.21
1.22
mmol/l
0.51
47
420
95
903
1.50
0.56
8.1
6.5
37.88
38.83
mmol/mol
0.77
84
843
16
117
1.43
0.56
1.4
2.1
—
—
—
0
0
25
200
1.33
0.53
1.7
1.8
—
—
—
0
0
35
294
1.28
0.52
3.2
3.3
1790.90
902.79
ng/l
0.41
28
249
30
248
1.29
0.51
7.8
4.2
1.02
1.02
kg/l
0.10
14
155
14
102
1.43
0.50
5.4
3.4
—
—
—
0
0
98
944
1.50
0.49
19.8
15.3
20.82
19.94
mg/l
0.11
80
754
93
886
1.40
0.48
5.2
4.2
1.25
1.24
mmol/l
0.10
86
810
7
48
1.49
0.48
1.3
1.2
—
—
—
0
0
51
453
1.24
0.47
2.0
2.0
1.25
1.31
mmol/l
0.28
44
378
7
49
1.46
0.47
1.0
1.1
—
—
—
0
0
16
124
1.34
0.41
1.4
2.0
—
—
—
0
0
51
458
1.22
0.41
2.2
2.1
101.08
99.97
pmol/l
0.06
20
221
0
16
0.00
0.41
0.0
1.6
—
15.70
—
0
16
97
935
1.44
0.37
5.9
5.1
1.53
1.58
mmol/l
0.57
92
858
21
173
1.27
0.36
1.8
1.7
1408.83
1157.76
nmol/l
0.45
12
122
10
76
1.35
0.29
1.7
1.3
—
—
—
0
0
8
63
1.29
0.28
16.3
8.0
0.74
0.63
%
—
8
63
20
169
1.23
0.28
1.6
2.0
—
—
—
0
0
8
64
1.27
0.28
16.3
7.9
1.41
1.47
%
—
8
64
8
65
1.25
0.28
1.6
1.8
—
—
—
0
0
19
161
1.22
0.26
2.8
3.2
8.64
4.66
e6/l
0.46
11
68
11
88
1.28
0.23
2.8
1.8
—
—
—
0
0
33
299
1.15
0.22
1.9
1.7
27.19
22.49
nmol/l
0.63
26
245
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
3.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
7.86
—
0
5
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
7
57
1.24
0.19
1.3
1.2
—
—
—
0
0
8
67
1.21
0.17
1.6
2.9
89.13
87.93
ng/l
—
8
61
11
94
1.19
0.13
3.1
1.8
—
—
—
0
0
40
379
1.09
0.12
5.9
3.8
22.99
22.72
ng/l
0.01
26
252
33
310
1.09
0.11
4.4
3.6
0.00
0.00
estimate
-0.00
14
82
48
463
1.07
0.08
3.4
2.8
—
—
estimate
—
0
0
25
238
1.07
0.05
2.9
2.4
—
—
—
0
0
14
150
0.92
0.04
1.4
1.7
30.70
29.41
s
0.29
14
145
26
254
1.03
0.00
2.5
2.7
345.71
321.33
umol/l
0.56
21
220
33
334
0.98
0.00
4.4
3.6
2.15
7.81
mg/mmol
1.71
19
186
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
4.55
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
113.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
10.76
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
84.94
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
29.28
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
-0.00
0.0
3.2
—
117.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
385.67
—
0
6
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_HAIRLOSS_SCARNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_HAIRLOSS_SCARNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_HAIRLOSS_SCARNAS – Other and unspecified cicatricial alopecia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data