neurotic excoriation: a condition in which patients produce skin lesions through repetitive, compulsive excoriation of their skin.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
223 |
4. Check minimum number of eventsNone |
223 |
5. Include endpointsNone |
223 |
6. Filter based on genotype QC (FinnGen only) |
189 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L98
- Name in latin
- Dermatitis artificialis
Similar endpoints
↥List of similar endpoints to
Factitial dermatitis
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue, not elsewhere classified
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1738 | 1165 | 556 |
| Only index persons | 1405 | 982 | 423 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 54.96 | 55.45 | 53.93 |
| Only index persons | 53.35 | 54.22 | 51.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 189 | 135 | 54 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | 49.44 | 48.77 | 51.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 196
- Matched controls
- 1960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L98.1
ICD-10 Finland
Factitial dermatitis
+∞
203.2
158
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
7.9
41.0
74
140
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.5
33.8
51
78
D07AD01
ATC
clobetasol; topical
6.3
33.2
76
179
D07AC01
ATC
betamethasone; topical
5.9
33.0
128
476
E0000UV, ,
ATC
5.9
31.2
140
580
D07BA04
ATC
hydrocortisone and antiseptics; topical
7.6
30.3
50
84
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.3
29.0
86
251
D07AC13
ATC
mometasone; topical
4.6
25.3
101
366
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
64.9
24.8
28
5
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
7.4
24.4
40
66
E000001, ,
ATC
4.8
23.9
76
230
S97
ICPC
Chronic ulcer skin
8.1
23.8
35
51
D07AB02
ATC
hydrocortisone butyrate; topical
4.4
23.7
99
368
SPAT1148
SPAT
Treatment of chronic ulcer or burn
5.7
23.4
52
116
D09AB01
ATC
zinc bandage without supplements; topical
40.5
22.8
28
8
69840
ICD-8 Finland
Pruritus and related conditions, Dermatitis factitia (artifacta)
+∞
22.3
21
*
L28.1
ICD-10 Finland
Prurigo nodularis
56.9
21.7
25
5
J01FF01
ATC
clindamycin; systemic
4.1
21.0
88
322
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.9
19.9
53
137
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
35.5
19.8
25
8
A46
ICD-10 Finland
Erysipelas
4.8
19.3
54
145
A10AB05
ATC
insulin aspart; parenteral
6.5
18.9
34
61
6984A
ICD-9 Finland
Pruritus and related conditions, Dermatitis factitia [artifacta][LICHENIFICATIO ET DERMATITIS ARTEFACTA]
+∞
18.0
17
*
J01CF05
ATC
flucloxacillin; systemic
5.8
17.2
35
71
D07BC01
ATC
betamethasone and antiseptics; topical
4.6
16.8
47
125
D07AA02
ATC
hydrocortisone; topical
4.1
16.4
57
179
L29.9
ICD-10 Finland
Pruritus, unspecified
15.6
16.0
26
19
N05AH04
ATC
quetiapine; oral
3.8
15.1
60
206
D07CC01
ATC
betamethasone and antibiotics; topical
4.1
14.9
50
152
E000002, ,
ATC
4.4
14.7
43
118
D06AX01
ATC
fusidic acid; topical
4.7
14.4
38
96
R06AE07
ATC
cetirizine; oral
3.2
14.1
116
614
C03CA01
ATC
furosemide; systemic
3.2
13.9
87
393
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.9
13.8
50
160
N06AX16
ATC
venlafaxine; oral
3.6
13.3
55
192
D07AB08
ATC
desonide; topical
4.0
12.9
42
124
A06AD11
ATC
lactulose; oral
3.8
12.8
46
146
N05AX08
ATC
risperidone; systemic
4.5
12.7
35
91
SPAT1240
SPAT
Therapeutic discussion
4.1
12.6
39
111
J01DC02
ATC
cefuroxime; systemic
5.6
12.3
25
50
A10AC01
ATC
insulin (human); parenteral
4.7
12.1
31
76
SPAT1262
SPAT
Handing over of treatment supplies
3.6
12.1
47
157
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
5.4
11.8
25
52
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
14.9
11.7
19
14
N05BA04
ATC
oxazepam; oral
2.9
11.7
80
374
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.3
11.5
25
53
A10AE04
ATC
insulin glargine; parenteral
4.2
11.1
33
91
S29
ICPC
Skin symptom/complaint other
3.0
11.0
64
272
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.0
10.9
35
102
TQW80
NOMESCO Finland
Local dermatologic skincare
14.0
10.9
18
14
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.4
10.9
30
78
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.8
10.7
26
61
L30.3
ICD-10 Finland
Infective dermatitis
9.0
10.7
22
27
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.4
10.5
22
45
Z00.8
ICD-10 Finland
Other general examinations
4.2
10.5
30
80
J01MA02
ATC
ciprofloxacin; systemic
2.7
10.5
95
508
N05BB01
ATC
hydroxyzine; systemic
4.4
10.4
28
71
SPAT1255
SPAT
Intravenous administration of medicine
4.9
10.3
24
54
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
10.3
76
365
103
Kela drug reimbursment
Diabetes, insulin-treated
2.8
10.2
70
323
J01AA07
ATC
tetracycline; systemic
3.2
10.2
47
174
N03AX16
ATC
[U] pregabalin
2.8
10.0
66
298
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
5.3
10.0
21
43
P29
ICPC
Psychological sympt/compl other
4.1
10.0
30
83
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.0
10.0
31
88
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.9
9.8
23
52
SPAT1260
SPAT
Consultation of another employee
3.0
9.8
52
208
A10AE05
ATC
insulin detemir; parenteral
5.5
9.8
20
40
L28.0
ICD-10 Finland
Lichen simplex chronicus
57.9
9.7
11
*
M79.6
ICD-10 Finland
Pain in limb
2.6
9.7
112
666
SPAT1301
SPAT
No procedures
2.6
9.6
80
407
H3603, E103,
ICD-10 Finland
104.9
9.5
10
*
R60.0
ICD-10 Finland
Localized oedema
3.3
9.5
42
151
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.8
9.5
63
285
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.7
9.4
33
102
L20.0
ICD-10 Finland
Besnier prurigo
4.1
9.4
28
77
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.5
9.3
24
59
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.7
9.2
32
98
Z2446
NOMESCO Finland
Social worker
4.6
9.2
23
55
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
16.6
9.2
14
9
N05AA02
ATC
levomepromazine; systemic
7.8
9.0
20
28
A10AB01
ATC
insulin (human); parenteral
8.3
8.9
19
25
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
7.6
8.8
20
29
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
17.3
8.7
13
8
SPAT1254
SPAT
Administration of medicine
3.1
8.7
43
165
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
3.2
8.3
37
133
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
8.3
51
220
P76
ICPC
Depressive disorder
3.8
8.3
27
79
N06AX21
ATC
duloxetine; oral
3.0
8.3
41
157
N05CF01
ATC
zopiclone; oral
2.4
8.3
82
446
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
10.7
8.2
15
15
L28.2
ICD-10 Finland
Other prurigo
34.9
8.2
10
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
34.9
8.2
10
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
34.9
8.2
10
*
SPAT1307
SPAT
Psychosocial counselling and guidance
4.6
8.2
20
47
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
4.6
8.2
20
47
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.5
8.1
73
380
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.9
7.9
19
30
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
10.0
7.9
15
16
EBA15
NOMESCO Finland
Extraction of multiple teeth
11.5
7.9
14
13
N05CD07
ATC
temazepam; oral
3.2
7.9
34
120
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
7.8
41
162
WZC00, ,
SPAT
2.9
7.7
41
163
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
26.2
7.6
10
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
26.2
7.6
10
*
N03AE01
ATC
clonazepam; systemic
4.2
7.5
21
55
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.9
7.5
15
18
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
7.8
7.4
16
22
S01
ICPC
Pain/tenderness of skin
4.8
7.3
17
38
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
7.3
57
275
I50.9
ICD-10 Finland
Heart failure, unspecified
2.9
7.3
39
155
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
7.3
32
114
K08.3
ICD-10 Finland
Retained dental root
3.8
7.2
23
66
E000006, ,
ATC
3.8
7.2
23
66
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
31.3
7.2
9
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
21.0
7.2
10
5
J01DB01
ATC
cefalexin; oral
3.3
7.2
173
1366
U04
ICPC
Incontinence urine
4.0
7.1
21
57
N05AH03
ATC
olanzapine; systemic
3.9
7.1
22
62
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.9
7.1
22
62
N02AA05
ATC
oxycodone; systemic
2.6
7.1
49
223
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.9
7.0
36
140
N06AB04
ATC
citalopram; systemic
2.5
7.0
56
273
J96.1
ICD-10 Finland
Chronic respiratory failure
14.5
7.0
11
8
A41.9
ICD-10 Finland
Sepsis, unspecified
6.5
6.9
17
28
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.4
6.9
27
89
N03AX12
ATC
[U] gabapentin; oral
2.6
6.9
47
212
NF1AA
NOMESCO Finland
Hip X-ray examination
3.3
6.9
28
95
WX892
NOMESCO Finland
Monitored bed care
3.7
6.8
22
64
N02AX02
ATC
tramadol; systemic, rectal
2.2
6.8
94
579
D07XC01
ATC
betamethasone; topical
3.0
6.7
32
119
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
23.5
6.7
9
*
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
4.4
6.7
17
41
P01
ICPC
Feeling anxious/nervous/tense
2.7
6.7
40
169
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
6.6
47
216
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.2
6.6
18
46
T90
ICPC
Diabetes non-insulin dependent
2.4
6.6
57
288
A10AA01, ,
ATC
7.8
6.5
14
19
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
6.5
45
204
E000003, ,
ATC
4.3
6.5
17
42
A10AA02, ,
ATC
6.4
6.5
16
27
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
8.6
6.4
13
16
J01DA01
ATC
[U] cefalexin
2.2
6.4
135
973
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
9.7
6.4
12
13
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
11.6
6.4
11
10
S76
ICPC
Skin infection other
3.9
6.4
19
52
NA1AD
NOMESCO Finland
Cervical spine CT examination
5.4
6.4
18
36
N03AG01
ATC
valproic acid; systemic, rectal
3.6
6.4
22
67
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
27.6
6.3
8
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
27.6
6.3
8
*
L28
ICPC
Limited function/disability (L)
2.4
6.2
49
236
R06AX27
ATC
desloratadine; oral
2.2
6.2
68
378
OAB50, ,
SPAT
3.6
6.2
21
63
T89
ICPC
Diabetes insulin dependent
5.5
6.2
17
33
P03
ICPC
Feeling depressed
3.0
6.2
30
113
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
9.0
6.1
12
14
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
10.5
6.1
11
11
C07AB07
ATC
bisoprolol; oral
2.1
6.1
108
722
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
6.1
60
319
H02AB06
ATC
prednisolone; systemic
2.1
6.1
106
704
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.6
6.0
41
184
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
7.6
6.0
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
67
278
3.14
12.16
3.7
2.1
11.66
13.49
umol/l
1.02
62
250
62
250
3.16
11.77
3.9
2.1
2.41
2.35
g/l
0.36
56
227
86
427
2.81
11.09
2.9
2.2
3.32
2.76
mg/l
0.48
79
364
121
735
2.69
10.20
9.6
3.9
34.75
36.13
g/l
1.81
114
700
45
168
3.18
9.56
1.8
2.0
313.40
390.13
nmol/l
2.01
45
159
59
267
2.73
8.80
3.2
1.8
—
—
—
0
0
96
568
2.35
7.93
4.7
3.0
54.37
29.19
u/l
0.49
90
542
59
283
2.55
7.72
1.8
1.7
1405.45
1066.56
nmol/l
1.23
47
209
64
323
2.46
7.49
2.0
1.7
521.37
471.48
pmol/l
0.59
54
273
122
844
2.18
6.41
15.0
6.3
1.20
1.22
mmol/l
1.22
103
725
33
129
2.87
6.36
5.9
3.0
114.34
69.01
ng/l
1.81
28
117
87
530
2.15
6.33
4.7
2.4
44.44
65.28
u/l
1.84
78
495
44
202
2.52
6.20
2.7
1.7
—
—
—
0
0
82
505
2.07
5.66
2.8
1.9
172.67
192.94
u/l
0.15
76
482
35
155
2.53
5.28
3.6
3.4
—
—
—
0
0
40
192
2.36
5.07
2.8
1.8
—
—
—
0
0
22
78
3.05
5.01
5.1
3.4
1.78
1.47
mmol/l
0.16
17
55
34
154
2.46
4.88
7.8
2.8
2.19
1.83
mmol/l
0.22
29
126
28
116
2.65
4.81
2.0
1.4
—
—
—
0
0
117
851
1.93
4.75
4.8
2.9
95.50
95.11
ug/l
0.01
107
792
110
784
1.92
4.75
13.0
5.6
1.20
1.22
mmol/l
1.15
101
711
12
22
5.74
4.68
1.4
1.5
—
—
—
0
0
123
914
1.93
4.64
8.5
5.9
9.30
10.65
umol/l
1.09
117
872
129
975
1.95
4.61
15.2
9.2
4.42
4.06
e9/l
0.95
120
850
50
277
2.08
4.44
5.0
2.9
0.81
0.81
mmol/l
0.15
45
263
24
97
2.68
4.33
8.4
3.1
5.42
4.99
kpa
1.38
24
91
83
556
1.85
4.21
6.2
3.8
34.44
8.48
mg/mmol
0.77
55
331
71
454
1.88
4.15
1.6
1.3
0.95
1.41
u/ml
0.38
21
120
16
54
3.14
3.95
1.9
1.3
276.21
322.88
ug/g
0.30
11
32
157
1305
2.02
3.81
13.2
7.4
88.30
78.19
u/l
1.94
151
1227
55
334
1.90
3.71
4.9
3.3
266.44
308.07
ng/l
0.07
39
252
37
196
2.09
3.66
3.2
2.8
6.01
7.04
umol/l
0.19
31
172
35
183
2.11
3.58
12.8
6.7
2.44
0.60
mmol/l
1.65
28
152
13
36
3.79
3.57
2.6
1.4
—
—
—
0
0
84
587
1.75
3.57
4.4
3.3
—
—
—
0
0
154
1283
1.93
3.55
6.7
4.2
15.27
11.87
mm/h
1.94
143
1194
37
200
2.05
3.47
1.8
1.6
1.52
1.37
%
0.42
27
173
102
758
1.72
3.44
2.3
2.1
96.72
98.15
pmol/l
0.13
56
389
27
129
2.27
3.43
20.4
5.2
13.48
8.73
mmol/l
1.89
27
120
65
426
1.79
3.41
3.2
2.7
333.37
334.30
umol/l
0.02
57
372
23
106
2.33
3.18
3.0
3.5
4.36
4.54
pmol/l
0.17
18
95
15
56
2.82
3.14
3.1
3.6
1.72
1.39
mg/l
0.73
15
50
27
135
2.16
3.09
2.5
3.0
60.55
65.00
ml/min/173m2
0.15
11
55
8
16
5.16
3.08
2.1
1.3
—
—
—
0
0
10
26
4.00
3.02
1.4
1.3
—
—
—
0
0
5
5
10.21
2.99
1.0
1.0
—
—
—
0
0
12
37
3.39
2.99
1.7
1.5
—
—
—
0
0
70
485
1.69
2.96
3.5
3.1
0.20
0.44
e6/l
1.29
57
351
104
799
1.64
2.94
3.4
2.4
75.24
77.00
nmol/l
0.30
97
714
72
505
1.67
2.90
3.8
3.1
2952.35
1191.77
ng/l
0.42
63
428
6
9
6.83
2.89
1.2
1.2
19.67
23.44
u/l
—
6
9
6
9
6.83
2.89
1.2
1.2
97.50
76.89
u/l
—
6
9
72
510
1.65
2.77
1.9
1.7
23.79
21.17
nmol/l
0.54
62
429
6
10
6.15
2.72
3.8
4.1
162.17
250.00
nmol/l
—
6
10
155
1340
1.75
2.60
6.1
4.3
14.61
14.80
pmol/l
0.35
142
1216
12
42
2.98
2.60
1.9
1.4
—
—
—
0
0
25
130
2.06
2.60
3.1
2.6
0.33
0.14
e6/l
0.44
25
123
6
11
5.59
2.56
2.7
1.1
—
—
—
0
0
81
602
1.59
2.52
4.1
3.0
2.33
2.36
mmol/l
0.92
67
550
181
1649
2.28
2.51
34.8
14.2
25.41
21.66
mg/l
0.85
159
1359
7
185
0.36
2.44
3.6
2.0
3.47
3.27
ratio
—
7
151
14
58
2.52
2.43
5.2
1.8
—
—
—
0
0
12
46
2.71
2.41
1.8
1.4
—
—
—
0
0
101
798
1.55
2.36
4.1
2.6
—
—
estimate
—
0
0
21
107
2.08
2.30
10.2
6.8
26.76
24.34
mmol/l
2.39
21
107
5
9
5.67
2.22
3.6
1.4
139.80
53.08
ng/l
—
5
9
59
418
1.59
2.20
3.0
2.2
—
—
—
0
0
7
19
3.78
2.17
2.6
1.4
10.14
9.74
mmol/l
—
7
19
136
1162
1.56
2.13
5.8
3.2
57.33
43.59
u/l
0.67
128
1103
83
644
1.50
2.03
5.0
3.8
64.42
38.54
ng/l
0.46
53
448
9
32
2.90
2.03
1.4
1.4
—
—
—
0
0
7
21
3.42
1.98
2.3
1.2
—
—
—
0
0
27
159
1.81
1.98
2.8
2.7
24.05
29.85
u/l
0.45
20
136
10
39
2.65
1.97
1.4
1.2
—
—
—
0
0
9
33
2.81
1.96
1.6
1.4
—
—
—
0
0
54
387
1.55
1.89
2.2
1.7
0.82
1.29
mg/l
1.31
38
317
11
46
2.47
1.89
1.1
1.1
—
0.91
—
0
7
5
12
4.24
1.83
1.2
1.2
—
—
—
0
0
6
18
3.40
1.76
1.0
1.1
—
—
—
0
0
5
13
3.92
1.72
1.4
1.8
—
—
—
0
0
5
13
3.92
1.72
1.4
1.8
—
—
—
0
0
5
13
3.92
1.72
1.4
1.8
—
—
—
0
0
5
13
3.92
1.72
1.0
1.2
—
—
—
0
0
48
342
1.53
1.72
1.2
1.4
12.13
27.79
iu/ml
2.74
15
117
8
31
2.65
1.68
1.1
1.1
—
—
—
0
0
55
408
1.48
1.63
6.3
3.9
1.02
1.02
kg/l
0.13
40
257
5
14
3.64
1.62
1.0
1.1
—
—
—
0
0
6
20
3.06
1.59
1.7
1.5
—
—
—
0
0
12
57
2.18
1.58
5.5
1.8
—
—
—
0
0
171
1581
1.64
1.51
7.9
5.3
1.88
1.87
mu/l
0.04
160
1453
21
125
1.76
1.51
1.3
1.3
286.12
164.52
u/ml
—
6
50
12
60
2.07
1.41
1.7
1.5
—
—
—
0
0
7
29
2.46
1.40
1.3
1.7
—
—
—
0
0
6
23
2.66
1.38
1.0
1.2
—
—
—
0
0
6
23
2.66
1.38
1.0
1.2
—
—
—
0
0
5
17
2.99
1.36
1.2
1.3
152.60
99.59
pmol/l
—
5
17
5
17
2.99
1.36
1.0
1.1
—
—
—
0
0
5
17
2.99
1.36
1.6
1.1
—
—
—
0
0
6
24
2.55
1.31
1.0
1.2
—
—
—
0
0
6
24
2.55
1.31
1.0
1.2
—
—
—
0
0
6
26
2.35
1.19
1.0
1.2
—
—
—
0
0
7
140
0.48
1.14
2.4
1.8
3.70
3.39
mmol/l
—
7
103
8
40
2.04
1.13
2.1
1.4
—
—
—
0
0
8
40
2.04
1.13
2.3
2.0
131.00
127.42
g/l
—
8
26
10
51
2.01
1.13
1.7
1.3
—
—
—
0
0
45
345
1.40
1.11
3.0
2.6
2.45
2.45
mmol/l
0.02
37
310
10
52
1.97
1.08
1.5
1.1
—
—
—
0
0
9
46
2.00
1.05
3.1
2.9
—
—
—
0
0
10
53
1.93
1.03
3.1
4.6
24.30
31.44
mg/l
—
10
47
10
53
1.93
1.03
3.2
4.6
24.34
43.94
mg/l
—
10
47
62
507
1.33
1.01
4.9
3.2
0.00
0.00
estimate
-0.00
21
142
12
69
1.79
0.99
1.3
1.6
1.21
1.16
g/l
0.25
12
69
7
36
1.98
0.98
2.1
1.4
—
—
—
0
0
41
318
1.37
0.94
1.4
1.3
24.86
11.67
u/ml
0.40
16
123
6
27
2.26
0.94
1.0
1.1
—
—
—
0
0
14
87
1.66
0.90
2.3
1.4
—
—
—
0
0
106
944
1.27
0.88
5.9
4.0
0.00
0.00
estimate
-0.00
22
170
6
30
2.03
0.87
1.5
1.4
—
—
—
0
0
6
30
2.03
0.87
1.5
1.4
—
—
—
0
0
80
693
1.26
0.83
6.0
3.8
0.00
0.01
estimate
0.50
19
153
164
1549
1.36
0.83
10.2
6.0
44.78
38.74
mmol/mol
5.71
156
1462
60
503
1.28
0.81
5.8
3.9
0.00
0.00
estimate
-0.00
23
166
35
272
1.35
0.80
3.2
3.0
3.78
2.85
e6/l
0.23
18
126
8
48
1.69
0.79
2.3
1.6
—
—
—
0
0
11
67
1.68
0.77
1.4
1.6
0.20
0.23
g/l
0.57
11
67
0
28
0.00
0.76
0.0
1.3
—
—
—
0
0
103
926
1.24
0.75
6.3
3.9
0.00
0.00
estimate
-0.00
24
180
22
161
1.41
0.72
11.0
6.3
1.23
1.32
mmol/l
0.19
22
161
14
93
1.54
0.71
3.0
1.8
—
—
—
0
0
5
26
1.95
0.71
1.8
1.5
—
—
—
0
0
103
936
1.21
0.64
6.3
3.9
0.00
0.00
estimate
-0.00
24
182
5
29
1.74
0.64
4.0
1.3
—
—
—
0
0
6
35
1.74
0.58
1.7
1.5
—
—
—
0
0
24
190
1.30
0.51
11.1
7.0
—
—
—
0
0
37
311
1.23
0.49
1.6
1.5
—
—
—
0
0
7
46
1.54
0.49
1.3
1.1
—
—
—
0
0
35
295
1.23
0.46
3.2
2.8
1.36
0.89
e6/l
0.33
17
148
30
249
1.24
0.45
3.3
4.2
22.61
21.82
%
0.08
15
116
113
1059
1.16
0.43
3.7
3.3
—
—
—
0
0
8
58
1.40
0.42
1.5
2.4
—
—
—
0
0
80
733
1.15
0.41
2.6
1.9
1.54
1.36
mmol/l
0.51
66
626
5
34
1.48
0.40
1.0
1.2
—
—
—
0
0
13
97
1.36
0.40
5.8
2.2
0.67
0.61
%
0.26
13
97
13
98
1.35
0.38
5.7
2.2
1.45
1.20
%
0.39
13
98
166
1609
1.21
0.38
6.2
4.9
6.76
5.88
mmol/l
3.77
150
1478
9
69
1.32
0.38
2.9
3.1
4583.67
2067.55
u/ml
—
9
60
178
1741
1.24
0.33
19.8
11.3
30.62
25.34
u/l
0.48
172
1694
7
57
1.24
0.29
1.6
1.1
—
—
—
0
0
7
57
1.24
0.29
1.6
1.1
—
—
—
0
0
19
221
0.84
0.24
5.9
4.8
29.86
32.64
%
0.41
14
140
7
93
0.74
0.23
1.6
1.5
—
—
—
0
0
5
41
1.23
0.22
1.6
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
12.56
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
16
138
1.17
0.18
1.4
1.4
—
—
—
0
0
8
71
1.13
0.16
1.9
2.4
27.13
41.43
u/l
—
8
64
32
347
0.91
0.15
1.3
1.7
—
—
—
0
0
163
1654
0.91
0.14
6.6
5.6
2.60
2.73
mmol/l
1.04
147
1543
19
205
0.92
0.08
1.2
2.3
—
—
—
0
0
7
66
1.06
0.08
1.1
1.4
—
307.32
—
0
35
161
1625
0.95
0.06
5.8
4.9
1.44
1.51
mmol/l
1.05
143
1513
11
99
1.12
0.06
1.8
2.2
—
—
—
0
0
11
100
1.11
0.05
1.1
1.0
—
—
—
0
0
13
120
1.09
0.05
2.2
2.3
—
—
—
0
0
162
1632
0.96
0.04
6.2
5.0
4.58
4.69
mmol/l
0.56
145
1526
11
104
1.06
0.01
1.4
1.3
—
47.70
—
0
8
19
187
1.02
0.00
1.2
2.2
—
—
—
0
0
155
1555
0.98
0.00
5.1
4.1
1.45
1.28
mmol/l
1.57
133
1432
12
118
1.02
0.00
2.7
2.5
—
14.96
—
0
9
0
7
0.00
0.00
0.0
5.3
—
98.71
—
0
7
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
11.19
—
0
7
0
7
0.00
0.00
0.0
1.3
—
10.05
—
0
7
0
8
0.00
0.00
0.0
4.6
—
200.50
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
23.90
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
59
0.84
-0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
53
0.94
-0.00
1.4
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_FACTITIALDERMAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_FACTITIALDERMAT | 1.852 [1.48, 2.32] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.356 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 821 females with L12_FACTITIALDERMAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_FACTITIALDERMAT | 2.697 [1.9, 3.82] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 141 out of 347 males with L12_FACTITIALDERMAT died.
Mortality risk
Mortality risk for people of age
years, who have L12_FACTITIALDERMAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.189% | 0.509% |
| 5 | 1.244% | 2.861% |
| 10 | 2.935% | 7.543% |
| 15 | 5.525% | 13.919% |
| 20 | 9.486% | 24.042% |
Relationships between endpoints
↥Index endpoint: L12_FACTITIALDERMAT – Factitial dermatitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data