Cutis laxa senilis

L12_CUTLAXSEN

photosensitivity disease: Photosensitivity refers to various symptoms, diseases and conditions caused or aggravated by exposure to sunlight.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L57.4
  • Hospital discharge: ICD-9 7018B
  • Cause of death: ICD-10 L57.4
  • Cause of death: ICD-9 7018B

2 out of 7 registries used, show all original rules.

307

4. Check minimum number of events

None

307

5. Include endpoints

None

307

6. Filter based on genotype QC (FinnGen only)

269

Control definitions (FinnGen only)

Control exclude
L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L57
Name in latin
Cutis laxa senilis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1483 1319 155
Only index persons 1385 1244 141
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.00
Only index persons 0.04 0.05 0.01
Median age at first event (years)
Whole population 55.73 54.96 62.05
Only index persons 55.47 54.72 62.05

-FinnGen-

Key figures

All Female Male
Number of individuals 269 244 25
Unadjusted period prevalence (%) 0.08 0.09 0.01
Median age at first event (years) 56.34 55.54 64.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
282
Matched controls
2820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L57.4
ICD-10 Finland
Cutis laxa senilis
+∞
307.7
262
*
QAJ30
NOMESCO Finland
Other facelift
509.5
80.2
76
*
QBJ30
NOMESCO Finland
Correction of abdominal apron
188.7
70.7
71
5
H02.3
ICD-10 Finland
Blepharochalasis
5.6
26.9
59
128
9862
FHL
Facial skin shaping surgery (Faclift)
+∞
23.2
22
*
L57.0
ICD-10 Finland
Actinic keratosis
6.0
22.8
44
84
7018B
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Other specified hypertrophic and atrophic conditions of skin[ELASTOSIS SENILIS]
+∞
21.1
20
*
E66.8
ICD-10 Finland
Other obesity
5.1
17.7
40
88
QBJ00
NOMESCO Finland
Liposuction in trunk
24.9
16.7
23
10
Z41.1
ICD-10 Finland
Other plastic surgery for unacceptable cosmetic appearance
31.5
11.8
15
5
J01DB01
ATC
cefalexin; oral
4.6
11.6
262
2084
QAJ15
NOMESCO Finland
Browlift using video-endoscope
114.1
10.5
11
*
QAJ99
NOMESCO Finland
Other aesthetic operations on skin of head or neck
+∞
10.5
10
*
A02BC05
ATC
esomeprazole; systemic
2.3
10.4
154
975
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.2
10.0
154
985
N06AB10
ATC
escitalopram; oral
2.5
9.8
81
397
J01EA01
ATC
trimethoprim; systemic
2.2
8.8
115
681
QAJ10
NOMESCO Finland
Browlift
51.6
8.7
10
*
Z42.2
ICD-10 Finland
Follow-up care involving plastic surgery of other parts of trunk
+∞
8.4
8
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
8.4
128
801
H02BX01
ATC
methylprednisolone, combinations; systemic
3.7
8.3
27
78
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
15.1
8.3
13
9
N06AB04
ATC
citalopram; systemic
2.2
7.9
86
470
J02AC01
ATC
fluconazole; systemic
2.0
7.9
152
1029
E66.9
ICD-10 Finland
Obesity, unspecified
4.1
7.9
22
57
WX402
NOMESCO Finland
General anaesthesia
2.2
7.8
81
434
CBJ50
NOMESCO Finland
Operation for ptosis of eyebrow
19.0
7.7
11
6
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.1
7.5
95
550
P06
ICPC
Sleep disturbance
2.5
7.4
52
234
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.5
7.4
49
215
M62.0
ICD-10 Finland
Diastasis of muscle
+∞
7.3
7
*
QBJ05
NOMESCO Finland
Other correction of loose or redundant skin of trunk
+∞
7.3
7
*
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
4.1
7.3
20
51
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.9
7.2
35
130
N05BA12
ATC
alprazolam; oral
2.6
7.1
46
199
SAA04
NOMESCO Finland
Special examination of mouth
3.6
7.0
24
72
N02BF01
ATC
gabapentin; oral
2.5
7.0
50
227
N06AB03
ATC
fluoxetine; oral
2.4
6.9
51
235
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
8.6
6.9
14
17
N62
ICD-10 Finland
Hypertrophy of breast
3.6
6.9
23
68
N05CF01
ATC
zopiclone; oral
2.0
6.8
118
758
XKC03
NOMESCO Finland
Water cystometry
4.2
6.7
18
45
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
6.7
77
427
M54.5
ICD-10 Finland
Low back pain
1.9
6.5
125
828
N02AX02
ATC
tramadol; systemic, rectal
1.9
6.5
140
963
N30.0
ICD-10 Finland
Acute cystitis
2.1
6.5
72
393
TQW99
NOMESCO Finland
Other minor procedure on skin
3.6
6.4
21
61
E66.01
ICD-10 Finland
Obesity due to excess calories
2.6
6.3
40
171
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
3.6
6.3
21
62
QAJ05
NOMESCO Finland
Other correction of loose or redundant skin of head or neck
+∞
6.3
6
*
QAJ00
NOMESCO Finland
Liposuction in head or neck
+∞
6.3
6
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
6.3
159
1149
J01DA01
ATC
[U] cefalexin
1.9
6.1
193
1492
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
6.1
47
221
M20.1
ICD-10 Finland
Hallux valgus (acquired)
2.4
6.0
45
208

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
128
854
1.91
6.54
2.2
2.0
111.08
147.62
u/l
1.65
123
806
169
1239
1.91
6.42
2.5
2.2
95.86
97.21
pmol/l
0.10
81
600
164
1225
1.81
5.53
2.6
2.8
—
—
estimate
—
0
0
167
1255
1.81
5.51
5.7
5.8
1.21
1.22
mmol/l
1.44
155
1145
63
349
2.04
5.39
1.9
2.0
130.61
119.72
ug/g
0.14
46
276
238
2016
2.16
5.31
8.6
8.0
73.77
78.71
u/l
1.45
230
1891
207
1678
1.88
5.16
3.7
3.2
44.28
43.35
u/l
0.05
193
1573
123
864
1.75
4.95
2.8
2.3
53.53
61.73
u/l
0.85
115
797
95
619
1.81
4.95
5.4
4.3
1.02
1.02
kg/l
0.66
63
417
167
1295
1.71
4.58
2.7
2.4
81.51
80.31
nmol/l
0.23
153
1136
176
1389
1.71
4.48
6.7
6.5
1.21
1.22
mmol/l
0.83
158
1189
100
680
1.73
4.41
3.6
3.6
92.55
92.65
%
0.01
94
666
241
2095
2.03
4.34
5.3
4.8
14.72
14.88
pmol/l
0.54
229
1915
129
951
1.66
4.15
3.8
3.4
—
—
—
0
0
156
1210
1.65
4.09
5.3
4.0
35.94
35.58
g/l
0.33
149
1143
69
431
1.80
4.04
3.1
2.8
0.80
0.81
mmol/l
0.31
63
400
42
224
2.03
3.95
1.4
1.1
—
—
—
0
0
139
1055
1.63
3.92
2.5
2.0
—
—
—
0
0
57
339
1.85
3.90
2.5
3.4
3.38
4.59
e9/l
2.56
44
295
187
1544
1.63
3.61
5.1
4.5
6.27
6.59
mmol/l
1.69
179
1458
51
305
1.82
3.42
2.2
2.3
5.56
6.70
umol/l
0.46
46
263
64
416
1.70
3.22
3.5
3.0
3.83
3.56
e6/l
0.09
36
187
155
1247
1.54
3.16
3.4
3.1
133.37
99.08
ug/l
0.40
148
1139
168
1376
1.55
3.16
6.6
6.0
0.18
0.18
e9/l
0.01
151
1189
164
1345
1.52
3.00
6.9
5.9
1.81
1.97
e9/l
0.79
150
1179
5
5
10.15
2.99
1.4
2.4
—
—
—
0
0
261
2404
2.15
2.97
7.0
6.1
1.80
1.87
mu/l
0.61
251
2221
143
1141
1.51
2.97
4.1
3.8
6.45
6.24
ph
1.34
77
626
114
867
1.53
2.96
2.1
2.4
—
—
—
0
0
231
2052
1.70
2.94
27.2
21.3
332.29
330.22
g/l
4.17
231
2046
7
207
0.32
2.93
3.3
3.5
—
—
—
0
0
6
9
6.78
2.88
1.2
1.8
115.17
118.11
nmol/l
—
6
9
67
940
0.62
2.87
3.8
3.3
—
—
—
0
0
115
882
1.51
2.85
3.4
3.7
7.40
7.40
ph
0.33
83
621
89
648
1.55
2.79
4.7
4.0
—
0.13
—
0
8
57
373
1.66
2.78
2.0
1.9
—
—
—
0
0
18
79
2.37
2.74
2.0
2.7
—
—
—
0
0
160
1322
1.49
2.71
6.7
5.9
0.53
0.56
e9/l
1.18
145
1124
90
661
1.53
2.71
1.4
1.3
5.72
1.94
u/ml
0.35
16
172
266
2481
2.27
2.71
20.2
16.0
21.04
22.52
mg/l
0.31
223
2043
112
864
1.49
2.66
3.8
3.3
87.08
30.99
e6/l
0.37
86
656
109
842
1.48
2.55
7.5
6.5
—
—
—
0
0
9
26
3.54
2.50
2.1
1.5
18.31
33.71
ng/l
—
9
26
99
753
1.49
2.49
3.6
3.2
0.53
0.54
e6/l
0.01
76
542
151
1248
1.45
2.47
6.6
5.9
27.77
28.16
%
0.16
143
1177
125
997
1.46
2.46
4.6
4.0
53.06
92.28
e6/l
0.74
95
685
38
230
1.75
2.46
4.3
6.6
1.23
1.26
mmol/l
0.09
38
224
92
694
1.48
2.40
4.1
4.0
—
—
—
0
0
159
1332
1.44
2.39
6.9
5.9
0.04
0.04
e9/l
0.01
144
1132
108
842
1.46
2.38
1.8
1.7
23.43
21.68
nmol/l
0.50
92
692
17
80
2.20
2.23
1.1
1.3
0.16
0.27
mg/l
—
8
28
20
101
2.06
2.21
3.8
3.8
—
—
—
0
0
27
152
1.86
2.21
2.3
2.5
—
—
—
0
0
45
295
1.63
2.18
6.5
7.2
7.44
7.42
ph
0.77
27
170
169
1448
1.42
2.14
4.7
4.2
0.00
0.01
estimate
—
8
276
147
1231
1.41
2.12
6.9
6.0
8.80
8.62
%
0.36
138
1147
33
201
1.73
2.10
4.4
7.7
—
—
—
0
0
89
686
1.43
2.03
2.8
2.2
2.56
3.15
mg/l
2.02
72
581
57
403
1.52
2.01
1.4
1.2
—
—
—
0
0
25
142
1.83
2.00
1.8
1.9
—
—
—
0
0
171
1478
1.40
2.00
8.9
10.0
3.79
4.02
e9/l
0.74
163
1292
5
11
4.61
1.95
2.8
3.8
1282.60
693.91
u/ml
—
5
11
31
190
1.71
1.94
1.2
1.3
—
—
—
0
0
166
1433
1.39
1.93
4.7
4.1
0.00
11.87
estimate
—
9
295
15
72
2.14
1.90
2.1
2.9
1.20
1.72
index
—
5
36
13
59
2.26
1.87
1.7
1.7
—
—
—
0
0
145
1229
1.37
1.86
6.8
6.0
0.73
0.71
%
0.17
136
1136
145
1230
1.37
1.85
6.8
5.9
3.11
2.77
%
1.18
136
1143
123
1018
1.37
1.82
3.5
3.9
15.18
91.92
ng/l
0.79
91
733
164
1421
1.37
1.82
4.7
4.1
0.00
0.00
estimate
—
9
284
145
1233
1.36
1.81
6.7
5.9
56.24
57.30
%
0.53
137
1168
17
90
1.95
1.69
1.4
1.3
247.20
293.29
ug/g
—
10
52
261
2474
1.74
1.66
5.9
5.4
5.78
5.91
mmol/l
0.90
247
2254
266
2536
1.86
1.64
17.2
14.2
—
—
—
0
0
143
1228
1.33
1.61
14.6
13.1
1.19
1.20
inr
0.10
119
1002
8
32
2.54
1.61
1.1
1.4
—
—
—
0
0
21
122
1.78
1.59
1.2
1.2
—
—
—
0
0
69
530
1.40
1.58
5.0
4.0
15.70
251.94
ng/l
2.97
59
414
82
649
1.37
1.57
2.0
2.7
325.91
324.03
umol/l
0.05
70
560
80
633
1.37
1.53
1.6
1.7
0.68
1.24
mg/l
2.55
65
524
95
775
1.34
1.49
3.4
3.3
—
0.11
—
0
19
13
66
2.02
1.46
1.1
1.1
3.44
3.81
mmol/l
0.94
13
60
37
258
1.50
1.41
4.1
4.1
7.32
7.36
ph
0.36
26
169
20
120
1.72
1.38
1.2
1.1
—
—
—
0
0
5
17
2.97
1.36
1.2
1.1
—
4.54
—
0
5
5
17
2.97
1.36
1.4
1.1
—
—
—
0
0
11
54
2.08
1.34
1.6
1.6
—
—
—
0
0
49
365
1.41
1.34
1.6
1.7
—
—
—
0
0
35
245
1.49
1.31
1.5
1.5
—
—
—
0
0
6
24
2.53
1.31
1.7
2.8
—
—
—
0
0
8
34
2.39
1.30
1.4
1.6
—
—
—
0
0
8
34
2.39
1.30
1.4
1.6
—
—
—
0
0
8
34
2.39
1.30
1.4
1.6
—
—
—
0
0
8
34
2.39
1.30
1.4
1.6
—
—
—
0
0
5
18
2.81
1.29
1.0
1.1
0.72
0.46
ratio
—
5
8
14
77
1.86
1.28
1.9
1.6
2549.75
17762.60
e6/l
—
8
48
23
148
1.60
1.24
7.6
4.3
—
—
—
0
0
9
45
2.03
1.24
2.0
1.9
46.89
58.64
%
—
9
45
37
266
1.45
1.22
2.5
2.5
38.58
32.14
u/l
0.25
31
218
8
37
2.20
1.22
1.1
1.2
—
—
—
0
0
0
35
0.00
1.16
0.0
1.0
—
—
—
0
0
15
88
1.74
1.13
1.2
1.3
—
—
—
0
0
8
40
2.03
1.13
1.3
1.2
—
—
—
0
0
71
577
1.31
1.13
1.9
1.6
1.99
2.35
g/l
1.11
35
333
109
940
1.26
1.08
3.9
3.6
—
0.80
—
0
5
104
898
1.25
1.01
3.3
3.1
6.72
6.63
mmol/l
0.08
93
751
39
296
1.37
0.98
1.8
1.5
—
—
—
0
0
101
873
1.24
0.97
3.4
3.2
20.22
37.26
mg/l
1.40
55
510
270
2624
1.68
0.96
14.5
12.5
23.72
23.76
u/l
0.02
265
2541
0
32
0.00
0.95
0.0
7.2
—
6.32
—
0
25
117
1032
1.23
0.92
3.2
3.2
2.35
2.37
mmol/l
1.13
104
929
6
28
2.17
0.92
1.5
1.1
—
—
—
0
0
69
577
1.26
0.88
1.3
1.3
29.46
34.92
iu/ml
0.14
24
192
31
232
1.38
0.86
2.2
2.7
69.50
76.13
ng/l
0.31
26
196
72
607
1.25
0.85
2.9
2.6
2.43
2.47
mmol/l
3.32
67
543
41
324
1.31
0.81
2.0
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
119
1066
1.20
0.78
4.8
3.9
0.00
0.01
estimate
—
6
227
12
76
1.60
0.73
1.2
1.2
500.58
491.01
mg/l
0.03
12
71
100
890
1.19
0.69
4.0
3.9
4.91
7.18
mg/mmol
0.49
58
504
7
42
1.68
0.69
1.6
1.2
53.48
19.23
u/l
—
7
33
254
2464
1.31
0.65
5.8
5.2
1.62
1.57
mmol/l
1.00
239
2258
5
29
1.74
0.64
1.2
1.4
—
—
—
0
0
5
29
1.74
0.64
1.0
1.1
—
—
—
0
0
255
2476
1.31
0.64
5.8
5.3
4.73
4.77
mmol/l
0.28
238
2287
11
71
1.57
0.63
1.1
1.1
—
—
—
0
0
16
113
1.44
0.62
1.1
1.4
—
—
—
0
0
258
2511
1.32
0.61
6.8
6.2
2.71
2.76
mmol/l
0.39
243
2305
8
51
1.58
0.61
1.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
2.37
—
0
11
248
2404
1.26
0.59
7.9
6.6
38.66
39.12
mmol/mol
0.40
237
2242
19
141
1.37
0.58
2.4
2.4
0.56
0.62
%
0.62
19
141
6
35
1.73
0.58
1.0
1.2
—
—
—
0
0
39
322
1.25
0.57
1.4
1.3
—
—
—
0
0
242
2344
1.23
0.55
4.9
4.4
1.25
1.25
mmol/l
0.05
222
2135
19
143
1.35
0.54
2.4
2.5
1.03
1.16
%
0.40
19
143
30
243
1.26
0.52
4.0
2.7
5.84
6.16
ph
1.18
16
163
28
227
1.26
0.49
2.1
3.3
62.61
73.72
e9/l
1.05
20
168
17
128
1.35
0.49
1.4
1.9
—
—
—
0
0
107
1160
0.87
0.48
8.5
11.1
0.00
0.00
e9/l
1.50
94
940
13
94
1.40
0.47
1.8
1.2
—
—
—
0
0
31
257
1.23
0.45
2.4
2.9
7.37
7.39
ph
0.59
15
151
5
31
1.62
0.43
1.6
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
80.29
—
0
7
0
15
0.00
0.41
0.0
1.3
—
95.69
—
0
15
0
18
0.00
0.40
0.0
1.3
—
281.08
—
0
12
53
594
0.87
0.38
5.6
4.6
—
—
—
0
0
70
769
0.88
0.38
4.0
3.5
0.00
0.00
estimate
—
6
225
10
72
1.40
0.37
1.7
2.3
12.75
10.97
mg/l
—
10
66
28
236
1.21
0.36
1.6
1.4
—
—
—
0
0
123
1157
1.11
0.36
2.0
1.9
1.34
1.32
mmol/l
0.10
110
964
14
178
0.78
0.35
2.5
1.8
3.08
3.51
mmol/l
—
9
138
31
265
1.19
0.35
1.4
1.5
—
—
—
0
0
6
43
1.40
0.35
1.3
1.6
—
—
—
0
0
62
561
1.13
0.35
1.7
1.7
537.72
464.41
pmol/l
0.90
54
457
6
45
1.34
0.34
1.0
1.0
—
—
—
0
0
6
88
0.67
0.33
2.0
2.4
25.32
25.23
mmol/l
—
6
88
44
391
1.15
0.32
1.3
1.4
380.00
584.71
titre
—
6
102
58
526
1.13
0.32
1.3
1.3
1.20
12.05
u/ml
4.49
17
205
30
260
1.17
0.30
1.3
1.6
—
—
—
0
0
38
336
1.15
0.30
1.5
1.5
—
—
—
0
0
7
56
1.26
0.29
1.1
1.1
—
—
—
0
0
15
122
1.24
0.27
2.1
3.0
24.85
25.32
mmol/l
0.15
15
122
9
73
1.24
0.25
1.1
1.2
—
—
—
0
0
38
341
1.13
0.25
1.3
1.2
—
—
—
0
0
19
221
0.85
0.23
3.7
5.0
0.00
0.11
%
—
8
57
7
93
0.75
0.23
1.0
1.3
—
2.23
—
0
12
22
252
0.86
0.22
1.3
1.3
—
—
—
0
0
13
107
1.23
0.22
1.2
1.1
—
—
—
0
0
18
209
0.85
0.22
3.9
4.6
0.00
0.16
%
—
8
56
0
11
0.00
0.21
0.0
1.7
—
141.64
—
0
11
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
0.00
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
5
43
1.17
0.21
1.4
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
16.1
—
847.00
—
0
14
22
193
1.15
0.20
1.0
1.2
197.48
188.94
u/ml
—
5
83
14
118
1.20
0.19
1.1
1.3
—
1.49
—
0
7
20
175
1.15
0.19
1.3
1.4
—
—
—
0
0
73
690
1.08
0.19
1.3
1.4
—
—
—
0
0
20
227
0.87
0.19
3.9
4.4
0.10
0.77
%
—
10
73
6
53
1.13
0.19
1.3
1.4
—
—
—
0
0
84
799
1.07
0.18
5.4
4.1
0.00
0.00
estimate
—
9
269
21
185
1.15
0.18
7.0
5.2
1.14
1.85
ug/l
0.91
21
158
52
486
1.09
0.17
1.9
1.7
1424.62
1207.78
nmol/l
0.80
39
357
5
69
0.72
0.17
1.0
1.2
0.86
0.93
g/l
—
5
69
13
111
1.18
0.16
4.2
4.6
36.78
36.90
°c
0.48
13
111
18
159
1.14
0.15
1.7
1.2
—
—
—
0
0
21
189
1.12
0.14
2.0
2.8
—
—
—
0
0
19
210
0.90
0.12
3.6
4.7
0.20
0.55
%
—
10
63
5
44
1.14
0.10
1.6
1.7
—
—
—
0
0
10
87
1.15
0.09
1.3
5.0
378.38
37.50
mg/l
—
10
74
10
87
1.15
0.09
1.3
5.0
18.24
84.83
mg/l
—
10
73
6
56
1.07
0.08
1.3
1.4
—
—
—
0
0
6
56
1.07
0.08
1.3
1.4
—
—
—
0
0
6
56
1.07
0.08
1.3
1.4
—
—
—
0
0
6
58
1.04
0.08
1.3
1.4
—
—
—
0
0
5
65
0.77
0.08
1.0
1.2
1.68
1.64
g/l
—
5
65
8
76
1.05
0.07
2.3
2.6
1.12
1.39
mg/l
—
8
65
7
80
0.87
0.07
1.0
1.1
—
88.00
—
0
10
17
161
1.06
0.03
1.2
1.6
—
—
—
0
0
32
326
0.98
0.00
2.4
4.0
22.28
6.64
ug/l
0.52
22
270
18
183
0.98
0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
20.72
—
0
6
6
65
0.92
-0.00
4.3
2.2
50.83
61.28
%
—
6
65
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.2
—
0.18
—
0
5
6
64
0.94
-0.00
1.5
2.0
—
—
—
0
0
5
53
0.94
-0.00
1.0
2.7
4.82
7.45
pmol/l
—
5
53
7
73
0.96
-0.00
14.6
9.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.3
—
1987.50
—
0
8
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
0.02
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_CUTLAXSEN and mortality.

Females

Parameter HR [95% CI] p-value
L12_CUTLAXSEN 0.901 [0.73, 1.12] 0.345
Birth year 0.992 [0.98, 1.0] 0.089

During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 879 females with L12_CUTLAXSEN died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_CUTLAXSEN.

N-year risk Females Males
1 0.068% No data
5 0.471% No data
10 1.246% No data
15 2.254% No data
20 3.936% No data

Relationships between endpoints

Index endpoint: L12_CUTLAXSEN – Cutis laxa senilis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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