Alopecia universalis

L12_ALOPECIA_UNIVERSALIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L63.1
  • Hospital discharge: ICD-9 7040D
  • Cause of death: ICD-10 L63.1
  • Cause of death: ICD-9 7040D

2 out of 7 registries used, show all original rules.

112

4. Check minimum number of events

None

112

5. Include endpoints

None

112

6. Filter based on genotype QC (FinnGen only)

103

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 103 68 35
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 48.74 48.04 50.11

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
107
Matched controls
1070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L63.1
ICD-10 Finland
Alopecia universalis
+∞
151.3
106
*
L63.9
ICD-10 Finland
Alopecia areata, unspecified
517.8
37.4
35
*
L63.0
ICD-10 Finland
Alopecia (capitis) totalis
+∞
34.2
31
*
L63.8
ICD-10 Finland
Other alopecia areata
289.5
23.6
23
*
D07AC13
ATC
mometasone; topical
6.9
22.7
63
184
S23
ICPC
Hair loss/baldness
57.9
20.1
23
5
D07AC01
ATC
betamethasone; topical
5.3
16.6
64
235
D07AD01
ATC
clobetasol; topical
5.7
15.6
38
94
H03AA01
ATC
levothyroxine sodium; systemic
4.3
11.7
42
139
XQ802
NOMESCO Finland
Epicutan test
10.2
8.4
16
18
L63
ICD-10 Finland
Alopecia areata
85.8
7.5
8
*
D07AB02
ATC
hydrocortisone butyrate; topical
3.1
7.3
46
210
L20.0
ICD-10 Finland
Besnier prurigo
4.2
7.3
22
62
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
4.0
7.2
23
68
E0000UV, ,
ATC
2.8
6.5
61
342

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
155
3.81
9.83
1.6
1.4
320.00
496.47
titre
—
9
34
27
73
4.61
9.61
1.4
1.2
91.45
119.14
u/ml
0.24
12
32
34
147
2.92
5.78
1.5
1.7
406.92
493.74
pmol/l
0.89
26
128
21
74
3.29
5.00
4.3
4.2
0.14
0.77
%
—
7
22
43
230
2.45
4.67
10.9
4.5
—
—
—
0
0
49
281
2.37
4.53
1.6
1.4
0.65
1.70
u/ml
0.97
13
73
95
741
3.51
4.45
7.4
4.6
15.23
14.71
pmol/l
1.20
88
687
20
74
3.09
4.38
4.5
4.6
0.00
0.05
%
—
6
20
54
330
2.28
4.24
7.7
6.6
—
—
—
0
0
20
77
2.96
4.09
4.5
4.2
0.58
0.65
%
—
6
26
69
474
2.28
4.00
3.8
3.1
78.22
95.14
ug/l
0.75
64
452
9
15
6.44
3.90
3.7
1.9
4.22
4.28
e9/l
—
9
15
23
102
2.60
3.61
1.7
2.6
280.70
393.46
nmol/l
2.85
23
95
8
13
6.55
3.57
1.3
1.1
—
—
—
0
0
70
503
2.13
3.38
11.0
6.3
0.57
0.56
e9/l
0.15
62
437
70
504
2.12
3.35
10.9
6.3
0.04
0.04
e9/l
0.66
62
434
42
250
2.12
3.35
4.5
4.1
9.74
79.37
mg/mmol
0.46
20
152
100
868
3.32
3.10
8.9
5.4
1.85
1.79
mu/l
0.24
94
812
17
70
2.70
3.06
3.9
4.0
4.29
4.73
pmol/l
1.13
17
62
70
514
2.05
3.06
11.0
6.3
1.90
1.93
e9/l
0.12
63
457
71
527
2.03
2.97
11.1
6.7
0.21
0.18
e9/l
0.92
62
462
10
27
3.98
2.97
3.9
1.7
58.60
60.79
%
—
10
27
56
386
1.95
2.87
6.2
3.3
0.06
0.01
estimate
0.36
16
86
9
23
4.17
2.84
2.9
2.4
7.40
7.43
ph
—
9
23
21
101
2.34
2.76
1.3
1.4
—
—
—
0
0
43
274
1.95
2.75
6.8
3.7
0.00
0.00
estimate
-0.00
18
98
40
249
1.97
2.74
2.1
1.4
2.08
2.41
g/l
0.72
27
151
6
10
6.28
2.73
1.8
1.2
—
—
—
0
0
6
10
6.28
2.73
1.2
2.2
39.90
30.79
umol/l
—
6
10
44
291
1.87
2.47
3.6
3.3
7.41
8.39
mmol/l
0.66
34
250
5
8
6.49
2.39
1.2
1.0
1209.80
986.75
u/ml
—
5
8
39
251
1.87
2.37
3.9
3.4
91.70
42.02
mg/l
0.51
18
160
41
270
1.84
2.31
4.0
2.9
—
—
—
0
0
7
19
3.86
2.19
2.6
2.2
4.80
4.95
kpa
—
7
19
7
19
3.86
2.19
2.6
2.2
10.10
8.84
kpa
—
7
19
7
19
3.86
2.19
2.7
2.3
19.03
16.39
%
—
7
19
10
37
2.87
2.13
1.1
1.2
—
—
—
0
0
16
77
2.27
2.09
6.2
2.9
—
—
—
0
0
5
10
5.18
2.09
1.2
2.0
—
—
—
0
0
34
218
1.82
2.05
6.8
3.7
1.02
1.02
kg/l
0.50
23
137
71
563
1.78
2.05
12.8
11.0
4.13
3.97
e9/l
0.23
63
492
55
407
1.72
2.02
2.0
1.9
1.33
1.40
mmol/l
0.34
44
351
53
390
1.71
1.98
10.0
8.2
1.21
1.22
mmol/l
0.44
48
367
5
11
4.71
1.96
1.0
2.0
15.22
19.00
ng/l
—
5
11
41
284
1.72
1.89
5.2
2.6
62.03
56.28
u/l
0.46
36
264
8
29
2.90
1.83
1.5
1.7
—
—
—
0
0
38
265
1.67
1.68
5.9
4.0
7.39
7.40
ph
0.59
30
190
58
451
1.62
1.67
17.5
11.2
0.00
0.00
e9/l
-0.00
51
357
19
108
1.92
1.64
1.4
1.9
—
—
—
0
0
49
368
1.61
1.61
9.1
9.3
1.08
1.12
inr
0.56
41
308
21
125
1.85
1.58
1.7
1.4
—
—
—
0
0
64
516
1.60
1.54
6.1
3.6
0.00
0.00
estimate
-0.00
19
102
30
201
1.68
1.52
1.3
1.3
25.15
11.70
u/ml
0.28
14
83
64
517
1.59
1.52
6.2
3.7
0.00
0.00
estimate
-0.00
19
102
10
45
2.35
1.51
8.2
5.1
—
—
—
0
0
19
112
1.85
1.47
1.9
1.7
1447.66
1153.26
nmol/l
0.48
12
84
24
153
1.73
1.45
1.6
1.7
—
—
—
0
0
29
195
1.67
1.45
1.8
1.7
—
—
—
0
0
10
46
2.29
1.45
1.2
1.1
0.85
0.84
g/l
—
10
46
12
60
2.13
1.44
3.5
1.5
—
—
—
0
0
64
521
1.57
1.44
6.4
3.7
0.15
0.00
estimate
0.48
20
96
22
138
1.75
1.40
1.3
1.4
—
—
—
0
0
54
428
1.53
1.34
10.7
9.6
1.21
1.22
mmol/l
0.55
42
373
33
234
1.59
1.33
1.8
1.6
22.15
21.54
nmol/l
0.10
28
199
8
34
2.46
1.32
1.4
1.3
—
—
—
0
0
9
44
2.14
1.30
1.0
1.1
1.60
1.60
g/l
—
9
44
8
35
2.39
1.30
1.4
1.3
—
106.00
—
0
5
46
354
1.53
1.30
2.2
2.0
91.98
101.68
pmol/l
0.69
26
182
39
290
1.54
1.28
4.8
3.0
0.00
0.00
estimate
-0.00
18
81
52
412
1.51
1.27
5.6
3.2
6.48
6.23
ph
1.03
33
221
93
841
1.81
1.24
6.9
5.6
40.42
38.53
mmol/mol
1.05
87
796
64
532
1.51
1.23
7.7
5.6
6.93
6.42
mmol/l
0.75
59
495
8
38
2.19
1.21
1.1
1.2
—
—
—
0
0
6
26
2.38
1.20
1.8
1.5
—
—
—
0
0
21
136
1.68
1.20
1.8
1.9
—
—
—
0
0
39
294
1.51
1.19
3.5
2.7
—
—
—
0
0
32
231
1.55
1.19
6.1
3.6
—
—
—
0
0
32
231
1.55
1.19
1.9
2.2
—
—
—
0
0
30
214
1.56
1.17
1.3
1.3
16.42
23.36
iu/ml
—
6
77
42
323
1.49
1.17
5.5
3.3
86.98
24.16
ng/l
0.61
33
194
24
163
1.61
1.15
2.0
1.7
—
—
—
0
0
15
89
1.80
1.15
1.2
1.8
—
—
—
0
0
10
52
2.02
1.10
1.7
1.7
—
—
—
0
0
98
910
1.91
1.09
6.0
4.8
4.63
4.76
mmol/l
0.62
90
862
38
293
1.46
1.02
4.3
3.4
25.56
33.40
e6/l
0.25
29
222
16
101
1.69
1.00
1.3
1.2
—
—
—
0
0
10
54
1.94
1.00
3.1
2.0
149.40
3451.29
u/l
—
5
18
0
28
0.00
0.99
0.0
3.1
—
19.05
—
0
28
98
917
1.82
0.98
6.6
5.2
2.74
2.80
mmol/l
0.33
90
864
32
241
1.47
0.96
4.2
3.3
0.88
0.35
e6/l
0.29
23
170
6
28
2.21
0.93
1.0
1.7
—
3.25
—
0
6
6
29
2.13
0.91
1.5
1.3
—
—
—
0
0
32
244
1.44
0.90
3.7
3.1
—
—
estimate
—
0
0
28
210
1.45
0.86
2.0
2.5
1.72
1.09
mg/l
0.36
23
176
6
31
1.99
0.86
3.3
1.7
—
—
—
0
0
32
252
1.38
0.75
5.9
2.8
—
—
—
0
0
7
40
1.80
0.73
2.4
2.3
—
—
—
0
0
42
349
1.33
0.70
5.0
4.2
188.57
29.95
e6/l
0.46
30
235
96
906
1.58
0.68
5.7
4.7
1.44
1.49
mmol/l
0.58
88
850
5
30
1.70
0.62
3.8
6.9
23.22
24.09
mmol/l
—
5
30
10
64
1.62
0.61
7.7
3.3
—
—
—
0
0
49
423
1.29
0.61
4.3
3.0
—
—
estimate
—
0
0
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
11
73
1.56
0.59
11.5
14.1
23.72
24.73
mmol/l
0.74
11
73
6
35
1.76
0.59
6.5
4.8
37.00
37.01
°c
—
6
35
102
980
1.87
0.58
23.4
12.5
—
—
—
0
0
92
868
1.43
0.57
5.1
4.0
1.26
1.28
mmol/l
0.14
85
810
28
227
1.32
0.54
8.9
4.5
—
—
—
0
0
7
45
1.59
0.50
11.0
2.5
1.17
1.53
%
—
7
45
7
45
1.59
0.50
1.3
2.3
—
—
—
0
0
16
120
1.39
0.50
8.8
10.0
1.14
1.13
mmol/l
0.09
16
111
7
47
1.52
0.48
1.4
1.2
—
—
—
0
0
44
387
1.23
0.44
2.3
2.0
—
—
—
0
0
8
58
1.41
0.42
1.3
1.2
—
—
—
0
0
33
285
1.23
0.38
2.2
1.6
—
—
—
0
0
69
641
1.22
0.38
5.9
4.3
—
—
—
0
0
10
72
1.43
0.38
2.1
2.4
—
4.94
—
0
5
17
135
1.31
0.38
2.2
2.1
—
—
—
0
0
98
949
1.39
0.38
24.9
14.6
16.81
21.93
mg/l
1.07
84
759
6
44
1.38
0.35
12.2
2.5
0.58
0.72
%
—
6
44
6
45
1.35
0.34
2.0
1.4
—
—
—
0
0
10
75
1.37
0.31
10.5
10.1
—
—
—
0
0
7
56
1.27
0.30
1.4
1.2
—
—
—
0
0
13
103
1.30
0.30
1.8
1.5
—
—
—
0
0
10
76
1.35
0.29
9.2
5.2
4.83
4.61
kpa
—
10
76
91
879
1.24
0.27
6.2
4.5
5.74
5.76
mmol/l
0.07
84
824
9
72
1.27
0.26
12.1
9.9
1.23
1.34
mmol/l
—
9
72
0
10
0.00
0.21
0.0
2.0
—
69.80
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
—
—
0
0
0
13
0.00
0.21
0.0
3.7
—
2.62
—
0
13
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
7
59
1.20
0.18
1.4
1.2
—
—
—
0
0
7
60
1.18
0.18
1.4
1.2
—
—
—
0
0
7
60
1.18
0.18
1.4
1.2
—
—
—
0
0
7
61
1.16
0.18
1.4
1.2
—
—
—
0
0
11
92
1.22
0.17
2.0
1.7
—
—
—
0
0
14
123
1.16
0.13
1.2
1.3
—
—
—
0
0
12
106
1.15
0.10
14.3
9.1
104.75
104.90
mmol/l
0.07
12
106
5
48
1.04
0.09
5.0
14.2
—
—
—
0
0
6
58
1.04
0.08
1.5
1.1
—
—
—
0
0
7
68
1.03
0.08
6.3
12.1
7.42
7.41
ph
—
7
60
7
68
1.03
0.08
1.0
1.1
—
—
—
0
0
7
84
0.82
0.07
2.3
1.9
—
0.00
estimate
—
0
20
9
84
1.08
0.07
1.6
1.3
—
—
—
0
0
43
443
0.95
0.05
3.0
2.8
—
—
—
0
0
31
298
1.06
0.05
3.9
7.5
—
—
—
0
0
13
120
1.09
0.05
1.2
1.2
—
—
—
0
0
15
158
0.94
0.02
6.2
3.6
680.56
147.51
ng/l
—
9
110
5
52
0.96
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
92.20
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.3
—
16.33
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
189.13
—
0
5
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
8.4
—
6.50
—
0
9
0
5
0.00
-0.00
0.0
1.8
—
0.00
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
8709.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
163.80
—
0
5
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
60
1.00
-0.00
10.8
3.9
25.65
24.14
mmol/l
—
6
60
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.4
—
0.75
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
37.62
—
0
5

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: L12_ALOPECIA_UNIVERSALIS – Alopecia universalis

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).