Acne keloid

L12_ACNEKELOID

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L73.0
  • Hospital discharge: ICD-9 7061D
  • Hospital discharge: ICD-8 70611
  • Cause of death: ICD-10 L73.0
  • Cause of death: ICD-9 7061D
  • Cause of death: ICD-8 70611

2 out of 7 registries used, show all original rules.

66

4. Check minimum number of events

None

66

5. Include endpoints

None

66

6. Filter based on genotype QC (FinnGen only)

58

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L73
Name in latin
Acne cheloides (scleroticans nuchae)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 511 157 348
Only index persons 476 151 325
Unadjusted period prevalence (%)
Whole population 0.01 0.00 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 35.43 37.86 34.35
Only index persons 35.04 38.25 33.56

-FinnGen-

Key figures

All Female Male
Number of individuals 58 25 33
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 36.38 40.98 32.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
62
Matched controls
620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L73.0
ICD-10 Finland
Acne keloid
+∞
77.1
57
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
8.8
13.5
21
34
D10BA01
ATC
isotretinoin; oral
15.5
13.1
22
21
J01AA07
ATC
tetracycline; systemic
7.4
12.8
25
52
L70.0
ICD-10 Finland
Acne vulgaris
65.6
10.0
11
*
L73.8
ICD-10 Finland
Other specified follicular disorders
45.1
6.9
8
*
D07XC01
ATC
betamethasone; topical
7.3
6.3
15
26
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.9
6.2
16
41

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
48
4.14
5.01
2.5
1.7
—
—
—
0
0
14
48
3.48
3.57
1.2
1.3
—
—
—
0
0
26
136
2.57
3.13
6.8
4.5
3.26
9.30
mg/mmol
1.11
16
92
26
136
2.57
3.13
5.6
3.7
34.13
50.65
mg/l
0.36
18
90
26
138
2.52
3.02
2.9
3.9
101.19
94.94
%
0.58
26
138
6
10
6.50
2.76
5.7
1.0
0.84
1.09
nmol/l
—
6
10
8
21
4.21
2.56
2.9
4.2
1.02
1.02
ratio
—
8
21
35
228
2.23
2.43
2.1
2.0
90.98
95.50
pmol/l
0.30
18
112
30
189
2.14
2.21
7.0
7.0
—
—
—
0
0
7
23
3.29
1.86
1.1
1.2
—
—
—
0
0
6
18
3.57
1.79
10.3
5.9
119.17
152.00
mg/l
—
6
9
7
24
3.15
1.78
2.7
1.5
—
10.46
—
0
5
5
15
3.53
1.55
3.2
2.1
—
—
—
0
0
44
346
1.94
1.52
7.8
4.5
—
—
—
0
0
5
16
3.30
1.46
2.6
1.3
22.18
24.62
mmol/l
—
5
16
29
203
1.81
1.43
2.0
1.9
—
—
—
0
0
14
78
2.03
1.34
3.1
1.8
15.13
13.85
umol/l
0.19
14
71
36
273
1.76
1.32
8.3
7.8
30.63
28.35
%
0.67
36
265
35
266
1.73
1.26
7.9
7.8
2.67
2.74
%
0.08
35
257
5
19
2.77
1.24
8.2
2.9
—
—
—
0
0
32
238
1.71
1.24
12.4
12.8
0.00
0.00
e9/l
0.50
25
197
12
65
2.05
1.23
1.5
1.5
—
—
—
0
0
35
267
1.71
1.23
7.9
7.8
8.56
8.82
%
0.25
35
259
14
81
1.94
1.21
1.2
1.6
—
—
—
0
0
7
30
2.50
1.16
2.6
1.8
—
—
—
0
0
21
141
1.74
1.15
4.9
4.8
—
—
—
0
0
19
124
1.77
1.14
4.2
3.5
—
—
—
0
0
8
41
2.09
1.13
8.0
6.5
1.26
1.45
mmol/l
—
8
41
35
271
1.67
1.13
8.1
7.5
53.87
57.17
%
1.14
35
262
13
76
1.90
1.09
2.8
1.9
—
—
—
0
0
31
235
1.64
1.07
2.5
2.7
—
—
estimate
—
0
0
36
285
1.63
1.04
7.5
7.7
0.04
0.04
e9/l
0.18
31
258
7
35
2.12
1.04
2.9
1.7
—
—
—
0
0
7
35
2.12
1.04
2.7
1.7
—
—
—
0
0
7
35
2.12
1.04
2.6
1.7
—
—
—
0
0
0
31
0.00
0.99
0.0
1.3
—
314.46
—
0
16
7
37
2.00
0.97
2.7
1.6
—
—
—
0
0
7
37
2.00
0.97
2.7
1.6
—
—
—
0
0
6
27
2.35
0.96
7.3
2.6
7.40
7.43
ph
—
6
22
39
320
1.59
0.93
6.8
4.6
—
45.80
—
0
5
8
46
1.85
0.86
5.0
2.7
6.04
5.55
kpa
—
8
46
26
197
1.55
0.86
6.0
3.9
20.61
9.29
e6/l
0.32
18
133
6
33
1.90
0.81
7.0
4.4
4.52
4.57
pmol/l
—
6
28
23
172
1.54
0.80
4.4
3.0
8.69
14.74
e6/l
1.04
18
128
38
317
1.51
0.79
14.7
13.5
3.96
3.87
e9/l
0.11
33
285
5
23
2.27
0.78
1.0
1.2
—
—
—
0
0
9
55
1.74
0.78
2.9
3.5
1.29
1.84
%
—
9
50
52
466
1.72
0.77
23.1
18.4
336.44
334.10
g/l
1.12
52
466
9
56
1.71
0.76
1.1
1.2
—
—
—
0
0
5
24
2.17
0.76
3.8
2.1
—
—
—
0
0
5
91
0.51
0.74
1.2
1.3
—
—
—
0
0
57
530
1.93
0.74
22.7
15.4
139.68
139.69
mmol/l
0.01
57
519
17
121
1.56
0.72
3.1
3.9
1.01
1.02
kg/l
—
9
75
5
29
1.79
0.65
1.6
2.4
23.00
24.76
mmol/l
—
5
29
5
30
1.72
0.63
1.4
1.2
—
—
—
0
0
5
30
1.72
0.63
12.0
7.7
26.00
24.70
mmol/l
—
5
30
34
286
1.42
0.62
5.8
3.7
0.00
0.00
estimate
—
6
47
9
62
1.53
0.56
8.1
7.9
102.78
104.89
mmol/l
—
9
62
9
63
1.50
0.55
1.6
1.4
—
—
—
0
0
22
176
1.39
0.52
2.0
2.2
—
—
—
0
0
16
124
1.39
0.44
2.1
1.5
2.97
2.64
g/l
0.33
11
82
8
57
1.46
0.44
1.3
1.4
—
—
—
0
0
5
31
1.67
0.44
12.0
8.4
94.80
91.24
%
—
5
31
5
33
1.56
0.42
1.4
1.4
3423.00
149.67
u/ml
—
5
27
5
33
1.56
0.42
12.0
7.8
0.46
0.68
%
—
5
33
28
239
1.31
0.42
5.8
3.3
5.93
6.25
ph
0.91
15
137
8
60
1.38
0.42
10.1
7.2
2.56
1.35
mmol/l
—
8
48
0
15
0.00
0.42
0.0
3.4
—
4.00
—
0
15
5
34
1.51
0.41
12.0
7.7
0.90
1.91
%
—
5
34
0
17
0.00
0.41
0.0
7.1
—
1.67
—
0
17
26
221
1.30
0.40
5.4
9.0
1.11
1.16
inr
0.33
21
187
5
36
1.42
0.39
9.2
3.3
—
—
—
0
0
19
155
1.33
0.38
4.0
2.8
0.22
0.19
e6/l
0.05
14
109
6
41
1.51
0.37
10.8
6.6
—
—
—
0
0
32
284
1.26
0.34
5.9
3.7
0.00
0.00
estimate
—
6
52
10
75
1.40
0.32
1.4
1.5
—
—
—
0
0
13
104
1.32
0.29
2.8
2.2
0.49
0.81
ug/l
—
8
64
5
71
0.68
0.28
1.0
1.3
—
—
—
0
0
31
281
1.21
0.25
6.1
3.6
0.00
0.00
estimate
—
6
52
5
37
1.38
0.24
2.2
2.6
4.60
4.89
kpa
—
5
37
19
165
1.22
0.23
7.8
7.6
—
—
—
0
0
5
42
1.21
0.22
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
30.55
—
0
11
0
11
0.00
0.21
0.0
1.0
—
1.63
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
14
118
1.24
0.21
1.7
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.49
—
0
7
0
12
0.00
0.21
0.0
1.2
—
4.88
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
6
47
1.31
0.21
1.8
1.6
—
—
—
0
0
17
147
1.22
0.21
4.5
4.3
7.38
7.40
ph
—
10
109
7
60
1.19
0.18
4.0
2.1
—
—
—
0
0
17
149
1.19
0.18
4.9
3.5
0.00
0.00
estimate
—
6
49
22
199
1.16
0.16
3.5
3.3
11.05
23.39
ng/l
2.84
13
125
15
168
0.86
0.14
4.8
3.4
—
—
—
0
0
14
124
1.17
0.12
3.0
5.7
—
—
—
0
0
12
107
1.15
0.09
2.1
1.6
—
—
—
0
0
16
150
1.09
0.05
2.8
2.2
—
—
—
0
0
17
162
1.07
0.02
1.5
1.4
—
—
—
0
0
17
164
1.05
0.00
5.1
3.1
0.00
0.00
estimate
—
5
43
25
249
1.01
0.00
3.6
2.8
—
—
—
0
0
22
216
1.03
0.00
5.0
3.4
0.00
0.00
estimate
—
6
47
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
113.60
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
295.39
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
32.71
—
0
7
0
9
0.00
-0.00
0.0
2.4
—
1.20
—
0
9
0
7
0.00
-0.00
0.0
2.7
—
18.86
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
94.80
—
0
5
0
8
0.00
-0.00
0.0
2.3
—
202.60
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
4.01
—
0
9
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
88.46
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
11.58
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.8
—
1.44
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
68
0.87
-0.00
6.0
3.6
2.84
4.70
e9/l
—
6
59
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
108.78
—
0
9
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_ACNEKELOID and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ACNEKELOID.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_ACNEKELOID – Acne keloid

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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