liver disease: A disease involving the liver.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
123 |
4. Check minimum number of eventsNone |
123 |
5. Include endpointsNone |
123 |
6. Filter based on genotype QC (FinnGen only) |
107 |
Control definitions (FinnGen only)
- Control exclude
- K11_LIVER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Liver disorders in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Diseases of liver
- Gastrointestinal diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 658 | 357 | 293 |
| Only index persons | 589 | 326 | 263 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 41.72 | 45.97 | 36.16 |
| Only index persons | 40.95 | 45.13 | 35.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 107 | 71 | 36 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | 48.04 | 46.53 | 51.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 111
- Matched controls
- 1110
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K77.0*B25.1
ICD-10 Finland
Cytomegaloviral hepatitis
+∞
66.5
57
*
K77.8*D86.8
ICD-10 Finland
Hepatic granulomas in sarcoidosis
+∞
30.6
28
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
10.2
27.4
38
54
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
+∞
20.4
19
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
38.6
17.8
22
7
R50.9
ICD-10 Finland
Fever, unspecified
5.8
17.1
42
105
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
32.3
14.8
19
7
L04AA06
ATC
mycophenolic acid; systemic
57.2
13.2
15
*
K76.9
ICD-10 Finland
Liver disease, unspecified
79.2
12.9
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.4
12.7
30
71
A05AA02
ATC
ursodeoxycholic acid; oral
34.3
12.0
15
5
K77.0
ICD-10 Finland
Liver disorders in infectious and parasitic diseases classified elsewhere
+∞
10.6
10
*
L04AD02
ATC
tacrolimus; systemic
108.9
9.6
10
*
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
+∞
9.5
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.5
9.3
70
365
127
Kela drug reimbursment
Transplant complication
40.3
9.2
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.9
9.2
17
18
JN4AD
NOMESCO Finland
Body CT examination
4.5
7.7
21
55
K83.0
ICD-10 Finland
Cholangitis
85.6
7.5
8
*
Z94.4
ICD-10 Finland
Liver transplant status
85.6
7.5
8
*
K77.8
ICD-10 Finland
Liver disorders in other diseases classified elsewhere
+∞
7.4
7
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
7.4
7
*
TK800
NOMESCO Finland
Hemodialysis
21.8
7.3
10
5
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
21.8
7.3
10
5
L04AX01
ATC
azathioprine; systemic
9.2
7.1
14
17
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
12.1
7.0
12
11
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
18.1
6.9
10
6
D86.0
ICD-10 Finland
Sarcoidosis of lung
18.1
6.9
10
6
M05BA04
ATC
alendronic acid; oral
7.4
6.6
15
23
C03DA01
ATC
spironolactone; oral
4.1
6.4
19
53
XF402
NOMESCO Finland
ECG with work load test
4.6
6.3
16
39
K77.0*B00.8
ICD-10 Finland
Herpesviral hepatitis
+∞
6.3
6
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
30
11.01
21.57
1.4
1.4
—
—
—
0
0
31
20
20.99
20.83
1.1
1.3
499.83
164.08
u/ml
1.60
12
12
45
135
4.92
14.56
4.4
2.2
2.42
2.37
g/l
0.19
40
123
60
249
4.07
12.19
4.5
2.9
0.15
0.31
e6/l
1.14
47
175
15
9
19.00
10.20
1.5
1.3
—
—
—
0
0
23
54
5.11
9.66
11.4
8.1
24.65
24.83
mmol/l
0.07
23
54
79
449
3.63
9.05
18.0
6.6
1.21
1.22
mmol/l
0.62
67
397
20
45
5.20
8.78
8.3
3.5
24.13
24.84
mmol/l
0.44
20
45
92
586
4.33
8.66
20.6
11.2
3.80
3.98
e9/l
0.37
87
519
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
13
12.12
8.06
2.5
3.3
0.19
0.52
iu/ml
—
5
8
48
216
3.15
7.88
2.5
2.1
2.31
2.76
mg/l
0.93
42
195
32
112
3.61
7.88
2.5
1.9
—
—
—
0
0
39
158
3.26
7.60
2.5
2.0
—
—
—
0
0
21
56
4.39
7.49
12.6
9.3
95.14
93.03
%
0.88
21
56
36
141
3.30
7.39
5.1
2.9
0.76
3.43
e6/l
1.65
22
71
38
155
3.21
7.29
4.8
2.8
0.81
0.81
mmol/l
0.04
33
145
79
487
3.16
7.17
5.5
3.1
154.45
92.96
ug/l
0.95
74
461
37
153
3.13
6.89
5.1
2.8
0.41
1.03
e6/l
1.97
24
82
31
118
3.26
6.60
2.4
1.8
—
—
—
0
0
19
52
4.20
6.52
13.8
8.5
23.54
24.32
mmol/l
0.60
19
52
15
24
7.05
6.43
7.6
2.5
1.95
1.33
mg/l
1.52
15
24
12
14
9.45
6.23
4.2
1.6
4.80
8.15
u/ml
0.39
12
14
14
22
7.12
6.09
1.8
2.6
1.07
1.49
ratio
—
5
9
18
50
4.10
6.05
2.2
1.6
—
—
—
0
0
21
66
3.69
5.96
13.6
7.6
1.06
1.11
mmol/l
0.13
21
66
10
9
12.06
5.92
1.2
1.1
—
—
—
0
0
30
119
3.08
5.91
11.3
6.8
104.63
103.64
mmol/l
0.52
30
119
55
309
2.55
5.50
4.7
2.2
61.14
68.31
u/l
0.21
50
291
43
217
2.60
5.35
3.3
2.2
—
—
—
0
0
9
9
10.75
5.13
4.6
2.2
1212.56
788.89
u/ml
—
9
9
77
523
2.54
4.91
5.9
3.5
0.00
0.00
estimate
-0.00
22
101
78
533
2.56
4.91
6.4
3.6
0.00
0.00
estimate
-0.00
18
98
21
75
3.22
4.87
3.0
3.0
—
—
—
0
0
12
23
5.71
4.61
2.7
1.2
0.00
0.00
g/l
-0.00
12
23
76
527
2.40
4.42
6.5
3.5
0.00
0.00
estimate
-0.00
22
101
30
146
2.45
3.89
2.0
1.8
1.41
1.40
%
0.02
24
136
16
62
2.85
3.21
3.4
1.3
—
—
—
0
0
18
75
2.67
3.16
3.6
2.7
62.88
70.33
ml/min/173m2
—
8
33
7
12
6.14
3.07
1.0
1.2
—
—
—
0
0
10
26
4.12
3.06
2.5
1.1
—
—
—
0
0
10
26
4.12
3.06
1.3
2.2
—
—
—
0
0
5
6
8.65
2.77
1.2
1.0
—
—
—
0
0
5
6
8.65
2.77
1.6
1.2
—
—
—
0
0
12
42
3.08
2.64
1.4
1.5
350.14
321.47
miu/ml
—
7
22
9
25
3.82
2.64
1.3
1.3
—
—
—
0
0
9
25
3.82
2.64
1.3
2.2
—
—
—
0
0
57
403
1.85
2.59
2.0
2.1
114.93
94.88
pmol/l
1.86
37
214
6
11
5.69
2.58
1.8
2.7
—
—
—
0
0
6
12
5.22
2.43
1.5
1.8
—
—
—
0
0
6
13
4.81
2.30
1.7
2.1
850.50
425.00
e6/l
—
6
7
18
88
2.25
2.27
2.7
3.9
3.42
58.77
ug/l
0.59
12
72
11
42
2.79
2.21
3.6
1.4
0.24
0.23
g/l
0.18
11
42
11
42
2.79
2.21
3.6
1.4
1.30
1.17
g/l
0.73
11
42
9
30
3.17
2.20
2.4
2.8
—
—
—
0
0
28
165
1.93
2.18
2.0
1.6
438.73
449.75
pmol/l
0.08
22
144
41
274
1.79
2.16
5.5
3.7
0.00
0.00
estimate
-0.00
20
98
41
276
1.77
2.10
2.7
2.1
112.27
141.77
u/l
0.59
41
269
10
39
2.72
2.00
1.5
1.4
—
—
—
0
0
43
299
1.72
1.94
5.6
2.7
0.00
0.00
estimate
-0.00
19
77
8
28
3.00
1.90
1.5
1.4
—
—
—
0
0
53
398
1.63
1.75
5.8
3.4
0.00
0.01
estimate
0.49
16
86
5
13
3.97
1.73
1.2
1.3
—
—
—
0
0
6
19
3.28
1.68
1.3
2.1
—
—
—
0
0
8
32
2.61
1.63
1.0
1.1
—
4.23
—
0
6
6
20
3.11
1.60
2.8
2.3
—
—
—
0
0
40
286
1.62
1.58
6.6
3.7
12.07
8.87
mg/mmol
0.23
23
169
59
465
1.57
1.54
4.2
2.5
—
—
estimate
—
0
0
32
219
1.65
1.49
2.7
1.7
1.17
1.01
mg/l
0.12
27
184
6
22
2.82
1.45
3.3
1.4
—
—
—
0
0
20
122
1.78
1.39
1.9
1.6
1905.08
1154.36
nmol/l
1.45
13
97
9
44
2.14
1.30
2.0
1.2
—
—
—
0
0
103
958
2.04
1.26
40.7
13.6
19.66
22.54
mg/l
0.42
98
767
6
26
2.38
1.20
1.2
2.0
—
—
—
0
0
38
284
1.51
1.20
1.7
1.3
0.68
0.82
u/ml
—
8
74
13
73
1.88
1.16
6.4
2.5
—
—
—
0
0
5
21
2.44
1.10
2.6
1.6
—
—
—
0
0
9
47
1.99
1.05
3.1
2.7
1.01
1.39
%
—
9
47
11
63
1.83
0.94
5.3
2.2
—
—
—
0
0
6
33
1.86
0.80
2.2
1.1
—
—
—
0
0
97
905
1.57
0.79
8.3
5.7
40.21
38.49
mmol/mol
0.77
92
860
9
54
1.72
0.77
3.0
1.3
—
—
—
0
0
85
776
1.41
0.76
5.8
4.8
14.89
14.68
pmol/l
0.34
77
725
30
233
1.39
0.76
1.3
1.3
19.83
16.73
iu/ml
0.17
11
73
25
189
1.42
0.73
2.2
1.7
—
—
—
0
0
5
27
1.89
0.69
2.4
1.6
22.98
25.17
mmol/l
—
5
27
31
248
1.35
0.65
1.8
1.7
—
—
—
0
0
42
352
1.31
0.65
4.6
3.5
17.29
31.10
ng/l
1.07
28
210
52
450
1.29
0.63
2.3
1.9
1.55
1.32
mmol/l
1.01
43
395
6
38
1.61
0.55
2.7
1.8
—
—
—
0
0
6
39
1.57
0.54
1.5
1.6
—
—
—
0
0
6
39
1.57
0.54
1.5
1.4
—
2.79
—
0
11
14
102
1.43
0.50
17.5
7.5
—
—
—
0
0
12
85
1.46
0.49
1.7
1.4
—
—
—
0
0
97
925
1.39
0.48
4.9
4.0
1.37
1.30
mmol/l
0.35
90
873
5
33
1.54
0.42
2.4
1.1
—
—
—
0
0
25
208
1.26
0.40
1.4
1.3
8.66
7.86
u/ml
—
9
78
7
51
1.40
0.32
7.9
1.6
2.43
3.07
mg/l
—
7
38
74
707
1.14
0.22
4.9
3.5
—
—
—
0
0
5
42
1.20
0.22
1.6
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
52
1.16
0.19
3.7
1.2
0.93
0.88
g/l
—
6
52
26
236
1.13
0.17
5.4
3.9
1.02
1.02
kg/l
0.52
19
154
14
151
0.92
0.05
1.9
2.1
3.71
3.53
ratio
—
9
125
12
111
1.09
0.04
1.7
2.0
3.57
3.55
mmol/l
—
6
83
16
169
0.94
0.03
4.4
4.3
15.72
20.63
%
—
9
79
91
917
0.96
0.01
7.1
5.6
1.79
1.83
mu/l
0.15
85
864
11
112
0.98
0.00
4.2
4.7
36.09
31.35
%
0.95
11
71
15
153
0.98
0.00
3.8
2.3
—
—
—
0
0
14
136
1.03
0.00
3.7
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.22
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.0
—
328.43
—
0
7
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
11.67
—
0
9
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_LIVDISINOTH and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_LIVDISINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_LIVDISINOTH – Liver disorders in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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