No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
755 |
4. Check minimum number of eventsNone |
755 |
5. Include endpointsNone |
755 |
6. Filter based on genotype QC (FinnGen only) |
676 |
Control definitions (FinnGen only)
- Control exclude
- K11_OESSTODUO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K22
- Name in latin
- Achalasia cardiae
Similar endpoints
↥List of similar endpoints to
Achalasia of cardia
based on the number of shared cases.
Similar with more cases:
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5195 | 2402 | 2748 |
| Only index persons | 4286 | 2011 | 2275 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.08 |
| Only index persons | 0.08 | 0.07 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 56.29 | 57.84 | 54.84 |
| Only index persons | 53.34 | 54.74 | 52.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 676 | 332 | 344 |
| Unadjusted period prevalence (%) | 0.14 | 0.12 | 0.16 |
| Median age at first event (years) | 54.75 | 51.02 | 58.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 699
- Matched controls
- 6990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
30.7
307.7
547
733
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
51.0
307.7
196
53
K22.0
ICD-10 Finland
Achalasia of cardia
+∞
307.7
577
*
R13
ICD-10 Finland
Dysphagia
19.6
277.2
250
193
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
112.3
264.8
136
15
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
27.0
220.5
160
76
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
361.5
213.1
205
8
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
70.9
188.2
103
17
UJD02
NOMESCO Finland
Gastroscopy
20.3
143.4
115
67
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
467.4
121.7
118
*
K22.2
ICD-10 Finland
Oesophageal obstruction
+∞
108.2
101
*
JCE21
NOMESCO Finland
Laparoscopic cardiomyotomy
+∞
100.5
94
*
A02BC05
ATC
esomeprazole; systemic
4.9
94.8
419
1639
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
9.1
84.0
112
144
K22.1
ICD-10 Finland
Ulcer of oesophagus
267.0
71.8
72
*
53009
ICD-8 Finland
Diseases of oesophagus, Functio laesa NUD
+∞
70.0
66
*
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
25.0
68.6
49
21
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
+∞
56.0
53
*
UJC12
NOMESCO Finland
Flexible oesophagoscopy
107.2
54.7
59
6
C08CA05
ATC
nifedipine; systemic
6.0
54.2
105
200
A02BC03
ATC
lansoprazole; oral
3.4
52.1
278
1133
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
535.1
51.1
50
*
A02BC04
ATC
rabeprazole; oral
5.3
46.9
105
227
A02BC02
ATC
pantoprazole; systemic
3.8
46.6
559
3588
A02BA02
ATC
ranitidine; systemic
3.6
46.6
202
716
A03FA02
ATC
cisapride; oral, rectal
5.5
46.2
98
202
53001
ICD-8 Finland
Diseases of oesophagus, Achalasia cardiae
+∞
44.2
42
*
K22.9
ICD-10 Finland
Disease of oesophagus, unspecified
454.7
43.7
43
*
A02BC01
ATC
omeprazole; systemic
3.0
39.0
251
1109
K30
ICD-10 Finland
Functional dyspepsia
4.7
34.9
88
209
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
11.4
34.0
36
33
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
32.9
292
1498
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
31.6
235
1101
5300A
ICD-9 Finland
Diseases of oesophagus, Achalasia and cardiospasm
+∞
31.5
30
*
K22.7
ICD-10 Finland
Barrett oesophagus
86.5
30.0
33
*
K20
ICD-10 Finland
Oesophagitis
59.4
29.4
34
6
JDB10
NOMESCO Finland
Percutaneous gastrostomy
11.6
28.6
30
27
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.2
27.5
126
450
JDA55
NOMESCO Finland
Endoscopic dilatation of stomach, pylorus or anastomosis of stomach
100.7
26.9
29
*
UJF32
NOMESCO Finland
Coloscopy
2.5
26.6
217
1051
T18.1
ICD-10 Finland
Foreign body in oesophagus
32.4
26.1
34
11
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.5
26.0
66
157
TJX90
NOMESCO Finland
Other minor procedure in gastroenterological surgery
140.2
25.8
27
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
25.7
393
2497
R12
ICD-10 Finland
Heartburn
3.8
23.7
77
220
WX402
NOMESCO Finland
General anaesthesia
2.5
23.3
197
961
XJC00
NOMESCO Finland
Oesophageal manometry
237.5
22.8
23
*
D21
ICPC
Swallowing problem
7.9
22.2
31
41
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.7
21.9
141
603
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
21.8
189
930
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
21.8
172
811
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.5
21.3
31
43
JCF12
NOMESCO Finland
Endoscopic insertion of prosthetic tube into oesphagus
35.0
21.3
27
8
1323
FHL
Esophagoscopy and dilatation
+∞
20.9
20
*
K22.8
ICD-10 Finland
Other specified diseases of oesophagus
216.2
20.7
21
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.8
20.4
47
103
ZXC96
NOMESCO Finland
Robot assisted procedure
5.5
20.4
40
76
N02AX02
ATC
tramadol; systemic, rectal
2.1
19.8
332
2114
XJC10
NOMESCO Finland
Oesophageal pH monitoring
205.6
19.7
20
*
WX002
NOMESCO Finland
Sedation and analgesia
2.4
19.4
167
814
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
4.6
19.2
47
108
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
18.9
285
1737
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
18.9
223
1239
JBW97
NOMESCO Finland
Other laparoscopic operation on diaphragm or laparoscopic or thoracoscopic operation for gastro-oesophageal reflux
+∞
18.8
18
*
JCA08
NOMESCO Finland
Endoscopic removal of foreign body from oesophagus
71.9
18.8
21
*
JDA32
NOMESCO Finland
Endoscopic injection in stomach or pylorus
71.9
18.8
21
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
18.6
234
1332
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
18.3
153
734
K29.3
ICD-10 Finland
Chronic superficial gastritis
45.3
18.3
22
5
J01MA12
ATC
levofloxacin; systemic
2.3
17.9
156
762
JCA98
NOMESCO Finland
Other local endoscopic operation on oesophagus
+∞
17.8
17
*
A07AA02
ATC
nystatin; oral
3.7
17.7
59
171
ZXE00
NOMESCO Finland
One hour or less
2.0
17.6
297
1874
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
184.5
17.6
18
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
17.5
117
506
K59.09
ICD-10 Finland
Constipation, unspecified
3.2
17.0
70
232
K29.7
ICD-10 Finland
Gastritis, unspecified
14.5
16.9
28
20
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
16.8
152
753
K22.3
ICD-10 Finland
Perforation of oesophagus
+∞
16.7
16
*
JBC00
NOMESCO Finland
Gastro-oesophageal antireflux operation
+∞
16.7
16
*
R53
ICD-10 Finland
Malaise and fatigue
2.1
16.7
202
1124
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
16.7
186
1003
K92.0
ICD-10 Finland
Haematemesis
7.5
16.6
24
33
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.3
16.6
148
729
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
16.1
104
442
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.0
16.0
46
120
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
15.8
72
254
UJF92
NOMESCO Finland
Capsular endoscopy
7.4
15.8
23
32
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
13.5
15.3
26
20
Y0599
ICD-8 Finland
Investigation of digestive system
6.3
14.7
25
41
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
14.3
203
1188
J01MA02
ATC
ciprofloxacin; systemic
1.9
14.2
288
1899
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
14.1
195
1130
R4190
NOMESCO Finland
Nutritional therapy
3.9
13.7
41
110
53094
ICD-8 Finland
Diseases of oesophagus, Oesophagitis
+∞
13.6
13
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
13.5
275
1808
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.7
13.4
76
301
R4110
NOMESCO Finland
Physiotherapy
1.9
13.3
210
1270
A03FA01
ATC
metoclopramide; systemic, rectal
2.0
13.3
167
933
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
13.2
118
578
R02
ICPC
Shortness of breath/dyspnoea
2.3
12.8
112
543
R01AD08
ATC
fluticasone; nasal
1.9
12.6
194
1162
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.7
12.6
73
293
6241
FHL
Fund application (Nissen)
+∞
12.5
12
*
K29.1
ICD-10 Finland
Other acute gastritis
24.8
12.5
17
7
GD1AD
NOMESCO Finland
Thorax CT examination
2.9
12.5
62
229
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
12.4
55
191
R03BA05
ATC
fluticasone; inhalant
2.1
12.3
128
665
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
5.1
12.2
26
53
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
12.2
101
478
N06AX11
ATC
mirtazapine; oral
1.8
12.2
239
1543
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
18.4
12.1
18
10
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
12.1
186
1111
JN4BD
NOMESCO Finland
Extensive body CT
2.4
11.9
90
409
C03CA01
ATC
furosemide; systemic
1.8
11.9
239
1552
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
11.9
134
717
Z3226
NOMESCO Finland
Physiotherapist
2.1
11.9
138
747
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
6.0
11.9
21
36
A02BA03
ATC
famotidine; systemic
4.1
11.6
32
81
N06AA09
ATC
amitriptyline; systemic
2.6
11.5
69
281
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
11.5
153
868
R11
ICD-10 Finland
Nausea and vomiting
2.5
11.3
73
308
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
11.3
65
259
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
11.3
142
789
R42
ICD-10 Finland
Dizziness and giddiness
1.9
11.3
180
1085
A01AB09
ATC
miconazole; local oral
2.6
11.3
68
278
A01AB04
ATC
amphotericin B; local oral
3.3
11.3
42
131
N03AX16
ATC
[U] pregabalin
1.9
11.3
161
936
N05AH04
ATC
quetiapine; oral
2.1
11.2
128
687
H02AB06
ATC
prednisolone; systemic
1.7
11.2
329
2376
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
11.1
162
947
ZXD05
NOMESCO Finland
Urgent procedure
1.8
11.1
217
1392
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
11.1
253
1699
L28
ICPC
Limited function/disability (L)
2.0
11.1
148
841
1310
FHL
Esophagogastroscopy
44.0
10.9
13
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.6
10.9
68
283
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.9
10.9
32
85
A02BA04
ATC
nizatidine; systemic
2.7
10.7
59
230
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
10.6
131
723
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.5
10.6
26
60
J02AC01
ATC
fluconazole; systemic
1.8
10.6
237
1580
R03AC02
ATC
salbutamol; inhalant
1.7
10.6
367
2758
K59.1
ICD-10 Finland
Functional diarrhoea
3.0
10.5
46
158
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
10.5
347
2571
R06AE07
ATC
cetirizine; oral
1.7
10.5
282
1978
K25.7
ICD-10 Finland
Gastric ulcer, Chronic without haemorrhage or perforation
111.6
10.4
11
*
5301A
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[OESOPHAGITIS REFLUENS]
+∞
10.4
10
*
K25.0
ICD-10 Finland
Gastric ulcer, Acute with haemorrhage
+∞
10.4
10
*
5308A
ICD-9 Finland
Diseases of oesophagus, Other specified disorders of oesophagus[HERNIA HIATUS OESOPHAGI (""""SLIDING HERNIA"""")]
+∞
10.4
10
*
R06.0
ICD-10 Finland
Dyspnoea
1.8
10.4
199
1266
D84
ICPC
Oesophagus disease
33.1
10.4
13
*
H02AB09
ATC
hydrocortisone; systemic
4.5
10.3
25
57
Z3231
NOMESCO Finland
Registered nurse
1.8
10.3
195
1235
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
10.3
147
852
K92.1
ICD-10 Finland
Melaena
3.1
10.3
43
144
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.1
10.3
106
547
C07AB02
ATC
metoprolol; systemic
1.9
10.3
153
899
UKC02
NOMESCO Finland
Cystoscopy
2.0
10.2
129
717
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
10.1
70
306
C01DA14
ATC
isosorbide mononitrate; oral
2.0
10.0
130
729
A01
ICPC
Pain general/multiple sites
2.3
9.9
78
361
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.3
9.7
37
117
J46
ICD-10 Finland
Status asthmaticus
4.3
9.7
25
60
J45.1
ICD-10 Finland
Nonallergic asthma
2.7
9.7
55
218
Z2221
NOMESCO Finland
Medical doctor
1.8
9.7
190
1214
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
9.6
116
633
N05CF01
ATC
zopiclone; oral
1.7
9.6
224
1502
WVA20
NOMESCO Finland
Medicine administration
3.6
9.6
31
88
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
9.5
300
2178
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
9.4
83
402
WX110
NOMESCO Finland
Infiltration anesthesia
1.7
9.4
476
3894
JCA96
NOMESCO Finland
Other local operation on oesophagus
+∞
9.4
9
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
9.4
106
566
D02
ICPC
Abdominal pain epigastric
2.9
9.3
45
164
A06AC51
ATC
ispaghula, combinations; oral
3.1
9.3
39
131
R01AD09
ATC
mometasone; nasal
1.7
9.2
289
2090
N03AE01
ATC
clonazepam; systemic
2.9
9.2
43
154
D03
ICPC
Heartburn
3.4
9.1
32
96
D10
ICPC
Vomiting
3.0
9.1
41
144
A28
ICPC
Limited function/disability NOS
1.9
9.0
142
846
G47.3
ICD-10 Finland
Sleep apnoea
1.8
9.0
157
966
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
9.0
122
693
A02BX02
ATC
sucralfate; oral
3.4
9.0
32
97
K29.4
ICD-10 Finland
Chronic atrophic gastritis
18.9
9.0
13
7
D06
ICPC
Abdominal pain localized other
2.4
8.9
65
291
J01FA09
ATC
clarithromycin; systemic
1.7
8.9
196
1291
A06AD11
ATC
lactulose; oral
1.9
8.8
116
652
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.9
8.8
42
152
R03DC03
ATC
montelukast; oral
2.0
8.8
106
578
J01MA14
ATC
moxifloxacin; systemic
2.3
8.7
71
333
UJC02
NOMESCO Finland
Rigid oesophagoscopy
14.3
8.7
14
10
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
8.7
114
640
K29.9
ICD-10 Finland
Gastroduodenitis, unspecified
50.6
8.7
10
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.8
8.7
43
159
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
4.5
8.7
21
48
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
8.7
85
430
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.4
8.6
59
256
XF402
NOMESCO Finland
ECG with work load test
2.2
8.5
75
363
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
8.5
122
705
J01DB01
ATC
cefalexin; oral
1.8
8.4
555
4792
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
5.0
8.4
18
37
6302
FHL
Esophagogastromyotomy (Heller)
+∞
8.3
8
*
R07.0
ICD-10 Finland
Pain in throat
2.6
8.3
47
186
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.2
8.3
73
354
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
8.3
223
1544
R07.3
ICD-10 Finland
Other chest pain
2.2
8.2
73
355
M79.6
ICD-10 Finland
Pain in limb
1.6
8.2
290
2145
R60.0
ICD-10 Finland
Localized oedema
2.0
8.2
93
496
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.1
8.1
86
447
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.4
8.1
56
244
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
8.1
64
296
N02BE01
ATC
paracetamol; systemic, rectal
1.9
8.1
609
5427
K29.6
ICD-10 Finland
Other gastritis
33.8
8.1
10
*
N05BA01
ATC
diazepam; systemic, rectal
2.0
8.0
91
485
M01AB55
ATC
diclofenac, combinations; oral
2.5
7.9
49
203
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.9
7.9
37
133
N05BA04
ATC
oxazepam; oral
1.7
7.8
174
1144
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
7.8
249
1793
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
7.8
278
2055
G04BD08
ATC
solifenacin; oral
2.4
7.8
53
230
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.6
7.7
43
169
R01AD12
ATC
fluticasone furoate; nasal
1.7
7.7
188
1265
R03BA01
ATC
beclometasone; inhalant
1.9
7.6
95
524
R03BB04
ATC
tiotropium bromide; inhalant
2.1
7.6
78
401
J01FF01
ATC
clindamycin; systemic
1.7
7.6
178
1185
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.0
7.6
34
119
Z02.7
ICD-10 Finland
Issue of medical certificate
2.3
7.6
58
265
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
7.6
45
183
R52.1
ICD-10 Finland
Chronic intractable pain
10.2
7.6
14
14
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.5
7.5
48
202
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
7.5
227
1610
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
7.5
79
410
WZC30
NOMESCO Finland
Teaching
1.8
7.5
119
710
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
80.9
7.4
8
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.0
7.4
33
115
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
7.4
129
790
P01AB01
ATC
metronidazole; oral, rectal
1.6
7.4
249
1810
N06AX21
ATC
duloxetine; oral
2.1
7.4
77
398
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.6
7.4
43
173
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.4
7.4
52
229
P25
ICPC
Phase of life problem adult
3.2
7.3
28
89
R49.01
ICD-10 Finland
Functional dysphonia
3.6
7.3
24
69
JCE20
NOMESCO Finland
Cardiomyotomy
+∞
7.3
7
*
K31.8
ICD-10 Finland
Other specified diseases of stomach and duodenum
+∞
7.3
7
*
K22
ICD-10 Finland
Other diseases of oesophagus
+∞
7.3
7
*
JCA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in oesophagus
+∞
7.3
7
*
M54.8
ICD-10 Finland
Other dorsalgia
2.9
7.3
34
122
M54.5
ICD-10 Finland
Low back pain
1.6
7.2
235
1692
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
7.2
195
1343
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
7.2
101
578
R03AC03
ATC
terbutaline; inhalant
1.9
7.2
89
490
J01DA01
ATC
[U] cefalexin
1.5
7.1
407
3321
J37.0
ICD-10 Finland
Chronic laryngitis
3.2
7.1
28
91
C03DA01
ATC
spironolactone; oral
1.9
7.0
94
530
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
7.0
110
652
R05
ICD-10 Finland
Cough
1.7
7.0
139
882
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.7
7.0
168
1122
J01FA10
ATC
azithromycin; systemic
1.5
7.0
351
2780
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
7.0
109
646
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
5.9
6.9
18
31
49300
ICD-8 Finland
Asthma, bronchiale
3.6
6.9
22
62
N03AX12
ATC
[U] gabapentin; oral
1.8
6.9
106
625
R03AK08
ATC
formoterol and beclometasone; inhalant
2.8
6.8
33
121
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
6.8
173
1173
R04.2
ICD-10 Finland
Haemoptysis
3.0
6.8
29
99
Z43.1
ICD-10 Finland
Attention to gastrostomy
40.5
6.8
8
*
JX1XB
NOMESCO Finland
Other X-ray examination of alimentary tract with contrast
40.5
6.8
8
*
B37.8
ICD-10 Finland
Candidiasis of other sites
40.5
6.8
8
*
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.9
6.8
31
110
UJK02
NOMESCO Finland
ERCP
3.6
6.8
22
63
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
4.0
6.7
19
49
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.9
6.7
83
457
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
6.5
6.7
16
25
B01AB05
ATC
enoxaparin; parenteral
1.6
6.6
212
1516
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.6
6.6
39
158
R52.2
ICD-10 Finland
Other chronic pain
3.0
6.6
28
95
A04
ICPC
Weakness/tiredness general
1.8
6.5
109
658
C10AC01
ATC
colestyramine; oral
3.7
6.5
20
55
R63.4
ICD-10 Finland
Abnormal weight loss
2.7
6.5
33
124
JN4AD
NOMESCO Finland
Body CT examination
1.9
6.5
86
484
E86
ICD-10 Finland
Volume depletion
3.4
6.5
23
70
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
6.4
263
1983
JCE96
NOMESCO Finland
Other reconstruction of oesophagus
70.5
6.4
7
*
JD1FN
NOMESCO Finland
Scintigraphy of gastric function
70.5
6.4
7
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.0
6.4
65
333
UJD10, ,
SPAT
3.6
6.4
20
56
G44.2
ICD-10 Finland
Tension-type headache
1.9
6.3
86
487
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
6.3
416
3457
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
3.9
6.3
18
47
K44.0
ICD-10 Finland
Diaphragmatic hernia with obstruction, without gangrene
18.2
6.3
9
5
R5140
NOMESCO Finland
Monitoring the use of the aid
1.9
6.3
79
437
K31.7
ICD-10 Finland
Polyp of stomach and duodenum
+∞
6.3
6
*
K22.5
ICD-10 Finland
Diverticulum of oesophagus, acquired
+∞
6.3
6
*
SPAT1104
SPAT
Monitoring of emergency patient
2.3
6.2
46
207
B03BA03
ATC
hydroxocobalamin; parenteral
2.5
6.2
39
163
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.2
6.2
24
77
XG474
NOMESCO Finland
Exhalation nntrogen oxide
3.6
6.2
20
57
Z01.9
ICD-10 Finland
Special examination, unspecified
2.3
6.2
48
221
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
6.2
278
2136
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.7
6.2
139
912
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
6.1
124
790
ZXA05
NOMESCO Finland
Left side
1.6
6.1
164
1123
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.0
6.1
64
332
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.5
6.1
38
159
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
10.1
6.0
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
455
2863
2.69
33.74
19.2
16.5
1.28
1.29
inr
0.24
391
2398
414
2619
2.42
28.31
5.5
4.9
35.23
35.45
g/l
0.35
397
2456
487
3493
2.30
22.37
8.3
5.0
6.41
6.67
mmol/l
2.40
473
3323
251
1431
2.18
20.12
3.0
2.3
—
—
—
0
0
289
1748
2.11
19.80
4.0
2.3
60.77
60.26
u/l
0.05
274
1633
256
1521
2.08
18.03
3.0
2.1
2.95
2.94
mg/l
0.02
233
1302
428
3064
2.02
17.74
7.9
6.6
11.29
11.72
umol/l
0.39
413
2939
246
1448
2.08
17.70
5.4
3.9
84.26
88.33
%
1.71
241
1424
396
2772
1.99
17.34
3.5
2.7
—
—
estimate
—
0
0
556
4415
2.27
17.08
10.2
8.1
78.46
79.52
u/l
0.22
539
4177
124
564
2.46
16.62
2.7
2.0
0.20
0.21
g/l
1.27
119
525
298
1918
1.97
16.40
3.3
3.1
32.92
33.19
u/l
0.02
286
1824
161
852
2.16
14.99
2.4
2.7
19.54
23.05
%
3.06
153
796
182
1010
2.08
14.96
3.8
3.3
0.81
0.82
mmol/l
0.43
174
954
118
556
2.35
14.51
9.6
7.4
1.59
1.31
mmol/l
0.77
118
548
331
2301
1.83
13.62
6.1
3.8
48.96
74.24
ng/l
0.31
255
1695
166
923
2.05
13.41
2.3
2.7
2.38
2.26
g/l
1.66
155
862
183
1058
1.99
13.24
2.5
1.9
—
—
—
0
0
527
4258
1.97
13.15
5.5
4.1
14.10
12.78
mm/h
1.09
491
3947
373
2715
1.80
12.95
8.5
6.7
1.20
1.21
mmol/l
2.00
349
2498
405
3045
1.78
12.37
9.5
7.3
1.20
1.21
mmol/l
2.13
357
2612
431
3311
1.79
12.12
10.1
9.9
4.27
4.19
e9/l
0.29
391
2875
363
2669
1.75
11.75
3.6
2.9
115.59
139.11
ug/l
1.40
342
2476
133
714
2.07
11.69
10.1
7.6
5.12
5.10
kpa
0.04
127
692
133
714
2.07
11.69
10.1
7.6
12.21
12.16
kpa
0.03
128
692
43
133
3.38
11.68
2.5
2.3
125.14
127.06
g/l
0.16
36
111
169
989
1.93
11.63
2.5
2.6
11.43
12.91
umol/l
2.01
160
923
78
336
2.49
11.61
3.8
3.8
1.85
1.89
mmol/l
0.04
59
247
36
101
3.70
11.32
1.4
1.7
—
—
—
0
0
349
2563
1.72
11.13
2.7
2.4
78.94
77.63
nmol/l
0.30
313
2306
90
423
2.29
11.02
1.8
1.6
—
—
—
0
0
145
820
1.97
10.97
4.7
6.0
1.03
1.03
mmol/l
0.08
137
747
130
711
2.02
10.81
10.2
7.6
1.19
1.05
mmol/l
0.13
110
587
44
146
3.15
10.69
1.5
1.3
262.63
279.50
ug/g
0.18
26
80
350
2617
1.68
10.10
2.5
2.1
90.51
94.89
pmol/l
1.13
198
1364
268
1868
1.70
10.08
2.8
2.1
181.86
221.19
u/l
0.62
256
1772
200
1287
1.78
9.98
1.9
1.7
0.96
1.33
mg/l
2.37
168
1011
166
1017
1.83
9.73
2.1
1.8
1097.77
1197.61
nmol/l
0.74
126
770
125
704
1.94
9.48
3.6
5.0
240.96
258.09
u/l
0.58
119
670
619
5484
2.12
9.37
25.7
15.8
79.98
79.26
ml/min/173m2
0.36
589
5083
268
1899
1.67
9.29
4.2
3.3
1291.17
1564.11
ng/l
0.81
235
1645
172
1087
1.77
9.02
1.8
1.5
2.23
2.55
g/l
1.34
107
681
467
3826
1.66
8.95
6.7
4.7
310.43
1533.80
e6/l
—
7
75
210
1415
1.69
8.71
3.7
2.7
5.79
5.64
e6/l
0.06
192
1306
112
628
1.93
8.57
1.8
2.1
207.11
118.21
ug/g
1.20
93
495
52
214
2.54
8.52
3.8
2.8
—
—
—
0
0
153
953
1.78
8.37
2.2
2.2
29.79
29.49
s
0.30
147
926
250
1782
1.63
8.25
2.0
1.7
19.49
20.20
nmol/l
0.33
222
1491
41
152
2.80
8.23
1.4
1.5
—
—
—
0
0
131
784
1.83
8.17
2.3
1.8
—
—
—
0
0
182
1205
1.69
7.96
1.3
1.3
0.66
1.42
u/ml
2.31
49
326
41
155
2.75
7.94
1.4
1.6
—
—
—
0
0
243
1737
1.61
7.85
4.1
3.2
0.60
0.50
e6/l
0.32
201
1298
279
2064
1.59
7.78
2.9
3.6
2.33
2.35
mmol/l
1.86
257
1884
457
3792
1.59
7.68
4.2
3.0
55.06
47.90
u/l
0.70
429
3579
627
5669
2.03
7.61
29.3
15.9
25.00
25.43
mg/l
0.14
570
4644
31
105
3.04
7.32
1.5
1.4
—
—
—
0
0
40
156
2.66
7.32
1.3
1.7
—
—
—
0
0
271
2020
1.56
7.17
4.5
3.4
58.59
74.37
e6/l
0.28
224
1576
291
2212
1.54
7.01
4.4
3.3
—
—
—
0
0
24
72
3.42
6.88
1.4
1.4
—
—
—
0
0
34
128
2.74
6.67
1.5
1.4
—
—
—
0
0
64
321
2.09
6.66
1.4
1.4
—
—
—
0
0
635
5819
2.00
6.61
33.1
19.3
3.97
3.99
mmol/l
0.98
626
5698
105
625
1.80
6.61
2.8
2.5
6.88
8.89
umol/l
0.94
85
553
27
90
3.08
6.56
1.6
1.5
—
—
—
0
0
50
229
2.27
6.52
2.2
1.9
—
—
—
0
0
170
1158
1.62
6.51
4.9
4.0
1742.70
329.16
ng/l
0.47
137
934
634
5815
1.97
6.46
33.1
19.1
139.49
139.67
mmol/l
1.06
626
5702
506
4382
1.56
6.33
5.2
4.2
15.02
14.88
pmol/l
0.61
467
4006
36
144
2.58
6.29
1.5
1.5
—
—
—
0
0
108
658
1.76
6.28
4.4
3.5
—
—
—
0
0
118
744
1.71
6.06
2.4
1.8
—
—
—
0
0
29
110
2.71
5.63
1.6
1.5
—
—
—
0
0
177
1257
1.55
5.58
1.9
1.7
496.40
16860897.07
pmol/l
0.74
144
1032
71
397
1.88
5.45
2.1
1.7
—
—
—
0
0
51
254
2.09
5.43
1.1
1.0
—
—
—
0
0
88
529
1.76
5.35
3.6
2.4
43.25
31.81
u/l
1.41
73
439
45
215
2.17
5.33
1.9
1.7
—
—
—
0
0
206
1531
1.49
5.20
2.9
2.9
344.23
349.47
umol/l
0.26
177
1361
96
598
1.70
5.14
3.7
3.6
2.80
1.95
mmol/l
1.48
83
505
20
66
3.09
4.98
1.4
1.4
—
—
—
0
0
19
61
3.17
4.94
4.2
2.9
21.69
28.29
mg/l
—
7
32
642
5997
1.86
4.94
16.0
11.7
26.26
25.92
u/l
0.18
626
5820
81
489
1.74
4.85
2.7
2.3
3.59
7.80
ug/l
3.94
65
432
645
6039
1.88
4.84
34.9
21.1
79.70
80.19
umol/l
0.17
638
5970
53
280
1.97
4.83
1.5
2.0
1.71
1.55
g/l
0.55
45
250
82
499
1.73
4.78
2.5
2.3
13.79
13.17
nmol/l
0.30
67
460
396
3364
1.41
4.69
3.4
2.9
—
—
—
0
0
32
140
2.35
4.68
4.5
3.3
0.82
0.83
nmol/l
0.07
23
122
40
193
2.14
4.65
3.1
2.7
1.58
1.63
mg/l
0.16
34
171
226
1747
1.43
4.56
5.9
4.0
0.01
0.00
estimate
0.22
95
622
371
3131
1.39
4.48
5.7
3.9
0.12
0.47
estimate
0.34
107
654
368
3106
1.39
4.42
5.7
3.9
0.00
5.03
estimate
0.80
106
697
42
211
2.05
4.41
3.5
3.3
0.46
1.11
g/l
0.91
37
187
81
507
1.68
4.27
4.6
4.1
1.21
1.23
mmol/l
1.17
74
432
76
471
1.69
4.16
3.2
2.9
67.77
64.22
ml/min/173m2
0.24
30
196
362
3070
1.37
4.11
5.8
3.9
0.00
0.00
estimate
0.50
104
677
147
1068
1.48
4.05
3.2
3.0
1.21
1.12
e6/l
0.13
83
580
32
150
2.19
4.02
2.6
2.2
252.69
3644.52
u/l
—
7
58
95
630
1.59
3.98
3.8
3.5
5.99
5.80
kpa
1.06
95
610
30
138
2.23
3.95
1.3
1.4
—
—
—
0
0
142
1031
1.47
3.92
1.4
1.3
21.04
33.80
iu/ml
1.48
55
315
78
496
1.64
3.88
3.2
3.1
210.54
232.44
ng/l
0.17
71
459
90
595
1.59
3.82
3.4
4.9
3.93
17.32
ug/l
1.18
71
498
6
5
12.09
3.77
1.0
1.0
—
—
—
0
0
16
55
2.95
3.76
1.3
2.2
—
—
—
0
0
20
78
2.61
3.74
1.2
1.2
—
—
—
0
0
570
5250
1.46
3.73
6.4
5.1
1.83
1.93
mu/l
1.42
538
4835
32
155
2.12
3.72
3.4
3.1
2.64
2.04
index
0.30
22
86
53
307
1.79
3.69
3.3
4.0
4.47
4.55
pmol/l
0.21
43
272
71
447
1.65
3.67
1.5
1.4
—
—
—
0
0
14
45
3.15
3.66
1.7
1.4
—
—
—
0
0
33
164
2.06
3.60
1.3
1.3
—
—
—
0
0
43
235
1.88
3.60
3.7
1.6
6.62
6.85
iu/ml
—
9
54
81
531
1.59
3.57
3.7
2.7
4.05
4.33
kpa
0.91
81
512
14
46
3.09
3.54
1.9
1.4
—
—
—
0
0
17
63
2.74
3.51
2.7
4.8
—
—
—
0
0
16
59
2.75
3.34
1.3
2.1
—
—
—
0
0
134
992
1.43
3.32
3.3
3.1
2.29
1.73
e6/l
0.42
70
503
38
206
1.89
3.28
7.6
3.5
1.67
1.31
mmol/l
0.35
38
201
18
74
2.47
3.07
1.6
1.4
—
—
—
0
0
647
6174
1.64
3.03
40.7
24.3
249.79
245.51
e9/l
0.90
637
6050
7
12
5.88
3.02
2.6
1.4
0.59
0.61
mmol/l
—
7
12
647
6176
1.64
3.00
40.5
24.2
91.24
91.33
fl
0.19
640
6109
11
31
3.59
3.00
1.9
1.5
—
—
—
0
0
647
6178
1.64
2.97
41.9
24.8
39.59
40.34
%
2.88
640
6107
647
6178
1.64
2.97
40.6
24.3
4.39
4.48
e12/l
4.25
635
6036
127
952
1.41
2.93
1.4
1.3
29.52
13.65
u/ml
0.76
46
359
647
6181
1.63
2.93
41.0
24.4
131.75
135.31
g/l
7.12
640
6111
55
347
1.63
2.86
3.7
3.9
24.89
24.38
mmol/l
0.53
55
341
572
5346
1.39
2.80
4.6
4.2
1.29
1.26
mmol/l
0.43
523
4885
277
2351
1.30
2.78
5.9
3.9
0.03
0.03
estimate
0.05
89
572
91
650
1.46
2.73
1.9
1.7
1.64
1.43
%
1.21
83
563
14
54
2.63
2.71
1.4
1.7
—
—
—
0
0
14
54
2.63
2.71
1.4
1.7
—
—
—
0
0
14
54
2.63
2.71
1.4
1.7
—
—
—
0
0
33
183
1.84
2.70
1.3
3.3
0.00
0.00
g/l
-0.00
28
162
38
222
1.75
2.63
1.6
1.2
0.18
1.88
u/ml
—
5
15
515
4753
1.32
2.63
31.9
20.1
13.85
13.65
%
2.58
510
4696
10
30
3.37
2.61
2.0
1.5
—
—
—
0
0
205
1685
1.31
2.58
5.1
3.4
0.03
0.06
estimate
0.19
86
539
24
121
2.02
2.58
1.2
1.3
113.12
1036.11
e6/l
0.51
17
97
24
121
2.02
2.58
1.2
1.2
2.81
89.61
e6/l
1.04
16
92
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
36
209
1.76
2.55
2.3
2.4
0.34
0.35
iu/ml
0.05
20
109
14
56
2.53
2.54
1.5
1.3
10.21
11.55
u/l
0.17
14
49
38
226
1.72
2.49
2.8
1.6
0.27
0.30
mg/l
0.15
20
105
8
21
3.84
2.47
1.8
1.0
—
—
—
0
0
16
70
2.32
2.42
1.1
1.4
—
—
—
0
0
16
70
2.32
2.42
1.1
1.4
—
—
—
0
0
67
462
1.50
2.41
2.9
4.1
67.11
92.20
ng/l
3.36
56
392
154
1231
1.32
2.36
2.6
3.1
2.44
2.45
mmol/l
1.28
141
1122
16
71
2.28
2.36
1.1
1.4
—
—
—
0
0
16
71
2.28
2.36
2.7
2.0
88.05
89.43
%
0.27
16
71
9
28
3.24
2.31
2.6
4.9
—
—
—
0
0
16
72
2.25
2.29
1.1
1.4
—
—
—
0
0
8
23
3.51
2.27
1.6
2.1
—
—
—
0
0
8
23
3.51
2.27
1.6
2.1
—
—
—
0
0
16
73
2.22
2.22
1.1
1.4
—
—
—
0
0
8
24
3.36
2.18
3.5
2.0
39.04
39.42
g/l
—
8
24
8
24
3.36
2.18
1.6
2.1
—
—
—
0
0
572
5405
1.32
2.14
7.2
6.3
39.26
39.31
mmol/mol
0.04
539
5066
21
109
1.96
2.12
1.5
1.6
—
—
—
0
0
38
237
1.64
2.12
2.0
2.0
47.50
38.45
u/l
1.50
32
210
242
2076
1.25
2.11
4.0
3.3
7.27
7.64
mmol/l
0.62
205
1751
11
43
2.58
2.08
1.5
1.2
0.23
1.28
u/ml
—
5
23
117
916
1.33
2.07
1.6
1.5
—
—
—
0
0
10
38
2.65
2.01
2.0
1.4
—
—
—
0
0
36
226
1.63
1.97
5.2
4.5
35.29
54.28
mg/l
1.45
28
189
36
226
1.63
1.97
5.2
4.5
38.30
41.23
mg/l
0.10
28
191
50
340
1.51
1.95
1.2
1.2
84.01
142.01
u/ml
0.53
19
140
10
39
2.59
1.94
2.5
3.7
0.90
0.77
index
—
10
39
16
78
2.08
1.92
1.2
1.4
—
—
—
0
0
25
143
1.78
1.91
1.9
1.3
26.49
10.20
u/ml
—
7
25
25
144
1.76
1.87
1.8
1.3
20.96
3.12
u/ml
—
5
17
580
5518
1.30
1.86
5.8
5.1
5.87
5.96
mmol/l
1.15
532
5035
90
690
1.35
1.84
11.1
7.0
—
—
—
0
0
15
73
2.08
1.81
1.1
1.4
—
—
—
0
0
32
200
1.63
1.80
4.6
4.4
1.32
2.73
ratio
1.73
17
121
8
29
2.78
1.79
1.0
1.6
142.54
93.84
ng/l
—
8
29
8
30
2.69
1.73
1.6
1.9
—
—
—
0
0
8
30
2.69
1.73
1.6
1.9
—
—
—
0
0
8
30
2.69
1.73
1.6
1.9
—
—
—
0
0
8
30
2.69
1.73
1.6
1.9
—
—
—
0
0
27
165
1.66
1.67
1.4
1.6
—
—
—
0
0
20
112
1.81
1.66
2.2
3.4
7.17
9.14
pmol/l
0.65
20
112
16
83
1.95
1.65
2.6
2.1
30.94
32.17
pg
0.51
16
83
16
83
1.95
1.65
1.5
1.2
2.86
5.87
u/ml
—
7
31
5
14
3.59
1.62
1.0
1.0
—
—
—
0
0
10
44
2.29
1.56
1.3
1.1
122.70
102.57
pmol/l
—
10
44
12
57
2.12
1.55
1.2
1.2
—
—
—
0
0
8
33
2.44
1.54
2.0
2.7
—
—
—
0
0
229
2019
1.20
1.45
4.4
4.1
5.03
9.72
mg/mmol
2.58
142
1259
22
133
1.68
1.44
1.9
1.9
346.67
5.44
iu/l
—
9
48
5
16
3.14
1.44
1.0
1.0
—
—
—
0
0
160
1367
1.22
1.40
6.0
4.1
1.02
1.02
kg/l
0.00
129
908
6
23
2.62
1.37
1.0
1.1
1436.50
1414.96
miu/ml
—
6
23
21
128
1.66
1.34
1.6
1.3
—
—
—
0
0
13
68
1.93
1.34
1.7
1.4
132242.86
23637.97
e6/l
—
7
32
49
361
1.38
1.32
2.4
2.5
42.33
20.08
au/ml
—
7
33
29
193
1.52
1.31
1.2
1.3
—
—
—
0
0
25
162
1.56
1.27
1.2
1.1
—
—
—
0
0
14
77
1.83
1.26
1.6
1.4
1645.13
1726.98
e6/l
—
8
47
25
163
1.55
1.24
1.2
1.1
—
—
—
0
0
23
149
1.56
1.18
1.2
1.3
—
—
—
0
0
10
50
2.01
1.17
1.0
1.0
—
—
—
0
0
7
31
2.27
1.10
1.7
1.4
—
—
—
0
0
13
75
1.75
1.03
1.2
1.1
—
—
—
0
0
23
157
1.48
0.97
1.4
1.4
—
—
—
0
0
578
5599
1.19
0.95
5.4
4.9
1.43
1.45
mmol/l
0.55
535
5166
6
27
2.23
0.93
1.7
3.4
696.17
952.22
u/ml
—
6
27
14
86
1.64
0.91
6.6
4.9
372.14
340.72
umol/l
0.51
14
74
83
697
1.22
0.89
4.9
4.7
34.35
32.20
%
0.81
55
445
6
29
2.08
0.89
1.3
1.8
3.00
10.17
u/field
—
6
19
22
152
1.46
0.89
1.4
2.1
14.15
12.53
mg/l
0.47
22
141
18
119
1.53
0.89
2.1
1.3
—
—
—
0
0
18
119
1.53
0.89
2.1
1.3
—
—
—
0
0
8
46
1.75
0.82
1.0
1.0
—
—
—
0
0
235
2161
1.13
0.82
5.7
5.5
2.31
3.32
ug/l
0.77
210
1942
10
58
1.73
0.80
2.4
2.5
—
—
—
0
0
65
777
0.82
0.79
1.5
1.5
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
160.94
—
0
24
6
33
1.83
0.79
1.0
1.0
—
—
—
0
0
579
5635
1.16
0.77
5.5
5.0
4.39
4.57
mmol/l
4.08
539
5226
6
34
1.77
0.76
1.0
1.2
—
—
—
0
0
9
54
1.68
0.74
1.0
1.1
—
—
—
0
0
5
24
2.09
0.74
1.0
1.3
—
—
—
0
0
7
38
1.85
0.73
1.3
1.1
—
—
—
0
0
9
57
1.59
0.71
1.2
1.1
96.00
93.98
%
—
9
52
9
57
1.59
0.71
1.0
1.1
—
—
—
0
0
10
158
0.63
0.71
1.5
1.6
—
—
—
0
0
5
26
1.93
0.70
1.4
1.2
—
—
—
0
0
5
26
1.93
0.70
1.4
1.2
—
—
—
0
0
587
5728
1.15
0.70
6.1
5.7
2.53
2.67
mmol/l
3.91
550
5302
35
275
1.29
0.69
1.4
1.3
—
—
—
0
0
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
15
102
1.48
0.68
1.0
1.2
259.29
264.05
u/ml
—
7
58
7
44
1.60
0.65
1.1
1.3
—
26.57
—
0
7
23
173
1.34
0.62
1.4
1.3
—
—
—
0
0
8
49
1.64
0.62
1.4
1.2
—
—
—
0
0
5
30
1.67
0.61
1.0
1.2
175.00
157.86
pmol/l
—
5
30
13
88
1.49
0.61
1.8
1.6
—
—
—
0
0
0
21
0.00
0.60
0.0
1.8
—
0.35
—
0
5
14
97
1.45
0.59
1.2
1.1
12.34
1.90
u/ml
—
9
55
59
505
1.18
0.57
1.5
2.0
—
—
—
0
0
5
86
0.58
0.56
1.0
1.0
—
—
—
0
0
6
37
1.63
0.55
1.8
2.8
5.00
1.16
%
—
6
37
7
45
1.56
0.49
1.4
1.8
—
—
—
0
0
62
545
1.15
0.45
1.6
2.1
—
—
—
0
0
7
51
1.38
0.44
2.0
2.8
415.00
1101.10
mg
—
7
51
5
31
1.62
0.43
1.6
1.1
—
—
—
0
0
5
31
1.62
0.43
1.6
1.1
—
—
—
0
0
8
56
1.43
0.42
1.1
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
5
34
1.47
0.40
1.4
1.3
—
—
—
0
0
5
34
1.47
0.40
1.4
1.3
—
—
—
0
0
5
34
1.47
0.40
1.8
1.6
1.98
1.15
promille
—
5
28
249
2376
1.07
0.39
1.9
1.9
1.47
1.33
mmol/l
0.67
201
1993
5
36
1.39
0.38
1.0
1.2
—
—
—
0
0
5
36
1.39
0.38
1.0
1.2
—
—
—
0
0
18
143
1.27
0.37
2.5
1.8
197.94
216.76
pmol/l
0.45
18
134
14
178
0.78
0.34
1.3
1.1
1.53
1.53
g/l
0.01
14
178
6
44
1.37
0.34
1.2
1.2
—
—
—
0
0
20
163
1.23
0.34
1.4
1.4
124.90
255.24
miu/ml
—
10
82
6
45
1.34
0.34
1.2
1.2
—
—
—
0
0
6
45
1.34
0.34
1.2
1.2
—
—
—
0
0
15
181
0.82
0.25
1.3
1.1
0.94
0.91
g/l
0.44
15
181
6
83
0.72
0.24
1.2
1.5
—
—
—
0
0
5
40
1.25
0.22
1.2
1.3
79.00
77.12
umol/l
—
5
40
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
5.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
1.15
—
0
10
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
6
49
1.23
0.20
1.2
1.2
—
—
—
0
0
6
50
1.20
0.19
1.0
1.4
—
—
—
0
0
180
1740
1.05
0.19
4.8
4.5
22.18
21.80
%
0.10
82
884
7
63
1.11
0.17
1.0
1.2
—
—
—
0
0
5
69
0.72
0.17
1.6
1.8
—
—
—
0
0
8
72
1.11
0.16
1.1
1.3
7.49
7.78
mmol/l
—
8
60
18
202
0.89
0.14
1.3
1.9
2.50
3.66
mg/l
0.47
12
149
22
241
0.91
0.12
1.5
2.0
—
—
—
0
0
5
45
1.11
0.10
1.0
1.2
—
—
—
0
0
43
409
1.05
0.09
1.5
1.7
3.39
3.47
mmol/l
0.21
28
286
7
66
1.06
0.08
1.6
1.5
—
—
—
0
0
16
147
1.09
0.07
2.5
2.5
16.75
98.95
ug/min
—
8
84
28
289
0.97
0.02
1.7
2.0
—
—
—
0
0
56
554
1.01
0.00
1.8
2.0
3.38
3.53
ratio
0.38
41
439
15
147
1.02
0.00
1.3
1.5
—
—
—
0
0
130
1303
1.00
0.00
3.6
3.2
0.68
0.76
ug/l
0.48
90
850
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
1.17
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
58
0.86
-0.00
1.4
4.4
15.82
71.07
u/ml
—
5
58
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
8.9
—
10.92
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint K11_ACHAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ACHAL | 1.679 [1.43, 1.97] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.159 |
During the follow-up period (1.1.1998 — 31.12.2019), 400 out of 1422 females with K11_ACHAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ACHAL | 1.729 [1.48, 2.03] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 597 out of 1737 males with K11_ACHAL died.
Mortality risk
Mortality risk for people of age
years, who have K11_ACHAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.182% | 0.257% |
| 5 | 1.003% | 1.676% |
| 10 | 2.602% | 4.449% |
| 15 | 4.928% | 8.826% |
| 20 | 8.809% | 15.009% |
Relationships between endpoints
↥Index endpoint: K11_ACHAL – Achalasia of cardia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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