eosinophilic pneumonia: An inflammatory lung disorder characterized by an increased number of eosinophils in the lungs. The majority of cases are idiopathic, without identifiable cause. In a minority of cases, medications, fungal infections, and environmental triggers have been implicated. It manifests as acute or chronic. Acute eosinophilic pneumonia is a severe and rapidly progressing pneumonia that may lead to respiratory failure requiring mechanical ventilation. Chronic eosinophilic pneumonia follows a slower course and manifests as fever, dyspnea, cough, and weight loss.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
487 |
4. Check minimum number of eventsNone |
487 |
5. Include endpointsNone |
487 |
6. Filter based on genotype QC (FinnGen only) |
436 |
Control definitions (FinnGen only)
- Control exclude
- J10_INTERSTITIUM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J80-J84
- Name in latin
- Eosinophilia pulmonum non alibi classificata
Similar endpoints
↥List of similar endpoints to
Pulmonary eosinophilia, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3168 | 1780 | 1353 |
| Only index persons | 2462 | 1464 | 998 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 59.21 | 58.03 | 60.60 |
| Only index persons | 56.56 | 55.95 | 57.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 436 | 244 | 192 |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | 57.90 | 54.33 | 62.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 447
- Matched controls
- 4470
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
+∞
307.7
393
*
TGC00
NOMESCO Finland
Bronchial lavation
32.7
148.3
100
39
UGC12
NOMESCO Finland
Flexible bronchoscopy
12.2
127.2
155
187
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
15.2
111.7
109
93
J45.1
ICD-10 Finland
Nonallergic asthma
11.3
111.5
139
171
H02AB06
ATC
prednisolone; systemic
14.5
100.7
400
1656
J45.0
ICD-10 Finland
Predominantly allergic asthma
9.5
97.1
139
202
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
7.1
95.6
229
576
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
8.0
90.9
159
289
J45.9
ICD-10 Finland
Asthma, unspecified
6.4
83.4
216
573
J18.9
ICD-10 Finland
Pneumonia, unspecified
6.3
83.0
272
889
R03DC03
ATC
montelukast; oral
5.4
60.0
162
429
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.1
55.5
95
163
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
6.0
54.2
114
240
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
+∞
52.1
49
*
J33.0
ICD-10 Finland
Polyp of nasal cavity
10.7
51.8
60
64
R03AK08
ATC
formoterol and beclometasone; inhalant
8.7
49.8
68
90
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.1
47.1
273
1238
J01MA14
ATC
moxifloxacin; systemic
5.4
46.4
108
247
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
9.9
45.9
56
64
5183A
ICD-9 Finland
Other diseases of lung, Pulmonary eosinophilia
+∞
44.5
42
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.4
44.2
144
432
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
43.4
41
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.6
43.3
66
99
R03BA02
ATC
budesonide; inhalant
4.1
41.5
159
534
M05BA04
ATC
alendronic acid; oral
5.0
41.3
106
262
L04AX01
ATC
azathioprine; systemic
9.4
41.2
52
62
D72.1
ICD-10 Finland
Eosinophilia
63.8
40.1
46
8
R03AC02
ATC
salbutamol; inhalant
4.0
38.2
333
1885
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.7
38.1
66
113
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.7
37.8
46
52
J46
ICD-10 Finland
Status asthmaticus
9.6
37.3
46
53
R03BA08
ATC
ciclesonide; inhalant
5.1
36.3
88
206
R03DA04
ATC
theophylline; systemic, rectal
5.8
35.5
71
140
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.6
34.7
52
76
R03BA01
ATC
beclometasone; inhalant
4.0
34.7
123
386
51920
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis eosinophilica
+∞
33.8
32
*
R03AC13
ATC
formoterol; inhalant
5.9
33.3
65
125
H02AB04
ATC
methylprednisolone; systemic
3.9
33.0
121
387
49300
ICD-8 Finland
Asthma, bronchiale
9.5
32.4
40
46
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.0
32.1
77
178
R03BB04
ATC
tiotropium bromide; inhalant
4.2
32.0
102
295
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
6.0
31.6
60
112
J33.8
ICD-10 Finland
Other polyp of sinus
10.0
31.3
37
40
XG410
NOMESCO Finland
Flow-volume spirometry
7.3
31.2
48
72
J45.8
ICD-10 Finland
Mixed asthma
7.9
30.6
44
61
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
30.3
302
1749
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
323.2
30.2
30
*
R03AK07
ATC
formoterol and budesonide; inhalant
3.2
27.3
142
562
R03BA05
ATC
fluticasone; inhalant
3.3
27.0
132
503
H02AB07
ATC
prednisone; oral
3.5
26.3
113
397
J47
ICD-10 Finland
Bronchiectasis
9.7
25.9
31
34
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
8.4
25.9
35
45
J01FA06
ATC
roxithromycin; oral
2.8
25.8
243
1323
R03AC12
ATC
salmeterol; inhalant
5.3
25.8
56
118
R01AD05
ATC
budesonide; nasal
4.5
25.7
70
178
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.0
25.2
40
62
J45
ICD-10 Finland
Asthma
3.9
24.3
82
244
J01MA12
ATC
levofloxacin; systemic
3.1
23.9
135
555
R03AK11
ATC
formoterol and fluticasone; inhalant
7.8
22.3
32
44
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
4.9
21.1
49
109
H02AB09
ATC
hydrocortisone; systemic
7.8
21.0
30
41
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
39.3
21.0
26
7
GD1AD
NOMESCO Finland
Thorax CT examination
4.1
20.1
59
158
A02BC02
ATC
pantoprazole; systemic
3.0
19.8
356
2541
R03AC03
ATC
terbutaline; inhalant
3.2
19.7
94
347
R01AD09
ATC
mometasone; nasal
2.4
19.1
241
1446
R01AD08
ATC
fluticasone; nasal
2.6
19.0
164
826
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.6
18.7
31
50
J32.4
ICD-10 Finland
Chronic pansinusitis
16.0
18.7
30
20
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.8
17.4
58
170
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
5.2
16.9
36
74
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
93.6
16.7
18
*
R96
ICPC
Asthma
3.1
16.3
75
270
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
16.0
264
1729
J31.0
ICD-10 Finland
Chronic rhinitis
3.6
15.9
58
180
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
5.9
14.8
27
48
J01FA15
ATC
telithromycin; oral
3.2
14.8
63
216
M05BA07
ATC
risedronic acid; oral
4.7
14.0
33
74
J01FA10
ATC
azithromycin; systemic
2.2
13.7
271
1863
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.7
13.6
45
131
R06AE07
ATC
cetirizine; oral
2.1
13.1
209
1317
M81.4
ICD-10 Finland
Drug-induced osteoporosis
29.4
13.0
17
6
WW200
NOMESCO Finland
Immunization
5.8
13.0
24
43
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
13.0
129
674
R06.0
ICD-10 Finland
Dyspnoea
2.2
12.8
161
925
DHB20
NOMESCO Finland
Polypectomy of internal nose
10.1
12.4
24
25
R81
ICPC
Pneumonia
4.2
12.0
33
84
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.5
11.9
30
71
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
19.6
11.7
17
9
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
11.5
53
190
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
11.4
115
601
XG474
NOMESCO Finland
Exhalation nntrogen oxide
4.8
11.3
26
57
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.1
11.0
125
684
J01FA09
ATC
clarithromycin; systemic
2.0
10.9
157
940
R06.2
ICD-10 Finland
Wheezing
3.7
10.8
35
100
Z3231
NOMESCO Finland
Registered nurse
2.1
10.8
148
869
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
18.4
10.8
16
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
10.7
98
492
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.2
10.6
45
153
M05BB03
ATC
alendronic acid and colecalciferol; oral
5.0
10.6
23
48
DPA30
NOMESCO Finland
Sphenotomy
14.7
10.6
17
12
R03DX09
ATC
mepolizumab; parenteral
+∞
10.5
10
*
R01AD12
ATC
fluticasone furoate; nasal
2.0
10.4
142
830
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
33.4
10.4
13
*
R05
ICD-10 Finland
Cough
2.1
10.3
115
623
R03DC01
ATC
zafirlukast; oral
7.8
10.3
23
31
R06AX27
ATC
desloratadine; oral
2.1
10.1
129
735
R01AD01
ATC
beclometasone; nasal
2.3
10.1
86
418
R02
ICPC
Shortness of breath/dyspnoea
2.3
9.9
83
400
XQ800
NOMESCO Finland
Prick test
3.1
9.7
43
150
J01AA02
ATC
doxycycline; systemic
2.2
9.7
368
3022
L04AA06
ATC
mycophenolic acid; systemic
8.7
9.7
20
24
297, ,
Kela drug reimbursment
+∞
9.4
9
*
J01MA02
ATC
ciprofloxacin; systemic
1.9
9.3
198
1337
J01CA04
ATC
amoxicillin; systemic
2.2
9.3
365
3006
R03BB01
ATC
ipratropium bromide; inhalant
3.3
9.2
36
117
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
19.1
9.0
13
7
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
7.1
8.9
21
31
R01BA52
ATC
pseudoephedrine, combinations; oral
1.9
8.9
147
910
1240
FHL
Bronchoscopy
8.2
8.9
19
24
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.5
8.9
62
274
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
8.9
103
563
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
14.4
8.7
14
10
A02BC01
ATC
omeprazole; systemic
1.9
8.5
145
905
3028
Kela drug reimbursment
Mepolizumab
91.7
8.4
9
*
P01BA02
ATC
hydroxychloroquine; oral
2.6
8.1
49
202
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.1
8.1
34
115
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
8.1
72
355
A07AA02
ATC
nystatin; oral
2.8
7.8
39
146
251, ,
Kela drug reimbursment
45.8
7.7
9
*
R03DX10
ATC
benralizumab; systemic
45.8
7.7
9
*
3027
Kela drug reimbursment
Benralizumab
45.8
7.7
9
*
J96.1
ICD-10 Finland
Chronic respiratory failure
4.6
7.7
18
40
J02AC03
ATC
voriconazole; systemic
25.5
7.6
10
*
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
10.3
7.6
14
14
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.3
7.5
29
93
Z3226
NOMESCO Finland
Physiotherapist
2.0
7.5
95
535
R01AD58
ATC
fluticasone, combinations; nasal
1.9
7.5
107
628
R06AX26
ATC
fexofenadine; oral
2.8
7.4
37
139
127
Kela drug reimbursment
Transplant complication
9.6
7.3
14
15
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
+∞
7.3
7
*
ZXA10
NOMESCO Finland
Bilateral
1.9
7.2
100
580
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.9
7.2
35
129
ZX120
NOMESCO Finland
Intravenous
2.3
7.1
57
268
J01DA06
ATC
[U] cefuroxime
2.1
7.0
77
411
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
7.7
7.0
15
20
A01AB04
ATC
amphotericin B; local oral
2.8
6.9
34
126
ZXE00
NOMESCO Finland
One hour or less
1.7
6.8
172
1192
E0000UV, ,
ATC
1.7
6.8
190
1353
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
9.5
6.8
13
14
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
9.5
6.8
13
14
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
40.7
6.8
8
*
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
17.0
6.8
10
6
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
6.6
6.7
16
25
R04.2
ICD-10 Finland
Haemoptysis
3.5
6.6
23
69
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
10.2
6.6
12
12
Z2221
NOMESCO Finland
Medical doctor
1.8
6.5
126
808
M05BX04
ATC
denosumab; parenteral
2.6
6.5
39
161
Z94.2
ICD-10 Finland
Lung transplant status
70.8
6.4
7
*
WZC30
NOMESCO Finland
Teaching
1.9
6.4
84
478
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
6.3
80
448
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.0
6.3
27
93
A02BC05
ATC
esomeprazole; systemic
1.7
6.3
190
1377
J20
ICD-10 Finland
Acute bronchitis
2.2
6.3
56
276
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
27.1
6.2
8
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
6.2
69
369
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
6.4
6.2
15
24
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
6.1
79
446
R50.9
ICD-10 Finland
Fever, unspecified
2.0
6.1
77
431
5BA08, ,
NOMESCO Finland
12.7
6.1
10
8
WX872
NOMESCO Finland
Intensive care
2.8
6.1
30
112
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
6.0
195
1432
L04AD01
ATC
ciclosporin; systemic
6.2
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
142
240
8.21
86.42
2.7
1.3
357.47
292.35
u/ml
0.26
135
222
51
25
22.90
68.07
1.9
1.2
4.41
0.13
u/ml
1.18
39
11
90
132
8.28
60.88
2.8
2.9
—
—
—
0
0
70
85
9.58
55.03
1.5
1.3
—
—
—
0
0
60
64
10.67
51.84
1.5
1.3
251.43
116.67
titre
—
7
6
40
34
12.82
39.94
1.2
1.1
—
—
—
0
0
345
2052
3.99
35.47
15.7
5.9
0.33
0.19
e9/l
18.00
329
1782
35
30
12.57
34.68
1.9
1.6
—
—
—
0
0
345
2198
3.50
28.63
16.6
9.5
4.92
4.06
e9/l
5.80
325
1907
36
43
9.02
28.26
4.1
4.1
—
—
—
0
0
51
93
6.06
27.45
1.7
1.5
—
—
—
0
0
53
103
5.70
26.68
2.0
1.6
—
—
—
0
0
42
70
6.52
24.67
2.1
1.8
—
—
—
0
0
45
84
5.84
23.58
1.7
1.5
—
—
—
0
0
93
310
3.53
23.27
2.6
1.4
—
—
—
0
0
51
110
5.10
22.80
2.0
1.6
—
—
—
0
0
45
89
5.51
22.15
1.1
1.2
—
—
—
0
0
34
51
7.13
21.99
1.7
1.6
—
—
—
0
0
57
153
4.12
19.36
1.7
1.7
14.39
8.67
iu/ml
—
9
40
100
390
3.01
19.05
2.6
2.0
311.11
382.68
nmol/l
0.96
95
357
35
66
5.67
18.08
1.8
1.6
—
—
—
0
0
25
34
7.73
17.55
2.3
1.9
—
—
—
0
0
263
1713
2.30
16.29
19.0
11.7
0.00
0.00
e9/l
0.17
233
1399
37
81
4.89
16.18
1.8
1.6
—
—
—
0
0
25
38
6.91
15.91
2.3
1.8
—
—
—
0
0
26
46
5.94
14.30
1.1
1.2
—
—
—
0
0
140
734
2.32
14.18
2.6
1.9
—
—
—
0
0
115
560
2.42
13.73
2.3
1.8
—
—
—
0
0
41
111
3.97
13.69
1.1
1.1
—
1.60
—
0
5
259
1756
2.13
13.52
3.3
2.5
82.76
79.09
nmol/l
1.15
246
1558
110
529
2.43
13.48
2.4
1.9
—
—
—
0
0
28
57
5.17
13.28
1.7
1.6
—
—
—
0
0
364
2856
2.48
12.82
9.7
4.4
14.49
12.56
mm/h
1.79
358
2654
41
117
3.76
12.71
1.9
1.5
—
—
—
0
0
44
133
3.56
12.54
1.3
1.2
0.35
0.19
u/ml
—
6
10
20
14
14.89
12.38
1.6
1.1
—
—
—
0
0
29
66
4.63
12.09
10.9
6.0
172.80
152.43
iu/ml
—
5
7
33
86
4.06
11.59
1.2
1.3
—
—
—
0
0
296
2193
2.04
11.19
7.3
6.4
10.53
11.39
umol/l
1.25
289
2087
282
2077
1.97
10.55
9.6
6.8
1.21
1.21
mmol/l
0.14
258
1802
34
98
3.67
10.38
1.9
2.1
124.63
127.36
g/l
0.22
24
81
261
1881
1.93
10.33
8.0
6.2
1.21
1.21
mmol/l
0.01
252
1720
36
113
3.38
9.68
1.6
1.5
1.28
0.01
iu/ml
—
8
15
16
14
11.80
9.13
3.5
1.4
39.25
71.74
ug/l
1.27
16
14
22
52
4.40
8.76
1.2
1.1
0.47
1.19
u/ml
0.92
13
26
66
304
2.37
8.68
1.7
1.6
—
—
—
0
0
361
2986
2.09
8.66
13.0
8.2
76.72
80.60
u/l
1.24
351
2819
27
78
3.62
8.22
1.3
1.4
—
—
—
0
0
27
78
3.62
8.22
1.3
1.4
—
—
—
0
0
18
38
4.89
8.18
1.9
1.5
—
—
—
0
0
18
38
4.89
8.18
1.9
1.5
—
—
—
0
0
18
38
4.89
8.18
1.9
1.5
—
—
—
0
0
53
232
2.46
7.78
4.1
2.6
1.91
1.94
mmol/l
0.02
42
168
68
334
2.22
7.68
3.4
3.3
224.71
216.92
ng/l
0.04
62
308
119
718
1.90
7.66
3.3
2.4
13.15
12.54
umol/l
0.30
112
662
161
1072
1.78
7.52
2.9
2.2
2.88
3.01
mg/l
0.31
143
920
139
892
1.81
7.31
2.0
1.6
1.38
1.29
mg/l
0.13
113
717
93
526
1.97
7.22
7.8
5.0
1.03
1.03
mmol/l
0.05
88
480
167
1139
1.74
7.09
4.2
3.3
0.30
0.43
e6/l
0.58
133
833
108
647
1.88
7.05
1.4
1.3
10.50
11.41
u/ml
0.06
36
253
297
2374
1.75
7.05
6.2
5.0
6.69
6.72
mmol/l
0.10
288
2261
131
835
1.80
7.01
4.6
4.2
186.92
298.09
ng/l
0.58
110
689
110
665
1.87
6.97
3.2
2.4
2.27
2.28
g/l
0.10
104
610
188
1336
1.70
6.82
4.3
3.5
145.31
113.89
e6/l
0.12
156
1031
88
498
1.96
6.80
6.5
7.8
1.55
1.02
mmol/l
0.51
75
423
11
9
12.49
6.61
1.9
1.9
—
—
—
0
0
11
9
12.49
6.61
1.9
1.9
—
—
—
0
0
140
929
1.74
6.44
3.2
2.7
4.06
5.11
e6/l
0.62
132
857
103
625
1.84
6.41
3.3
2.3
23.14
21.92
%
0.38
97
583
11
10
11.24
6.33
2.0
1.8
—
—
—
0
0
260
2042
1.65
6.23
3.3
2.7
—
—
—
0
0
113
712
1.79
6.19
1.5
1.3
22.80
32.77
iu/ml
0.74
35
227
20
58
3.56
6.08
1.3
1.4
—
—
—
0
0
12
15
8.19
5.87
1.8
1.9
—
—
—
0
0
180
1307
1.63
5.77
4.0
3.3
28.62
32.12
u/l
1.55
172
1234
16
41
4.01
5.76
1.2
1.0
0.29
0.35
u/ml
0.09
11
20
235
1825
1.61
5.69
7.4
4.7
33.83
35.38
g/l
4.07
227
1712
16
32
5.15
5.61
1.1
1.0
0.79
0.92
u/ml
0.09
11
11
59
310
2.04
5.58
4.0
3.5
88.05
81.91
ng/l
0.23
50
270
8
5
16.24
5.43
1.4
1.4
—
—
—
0
0
186
1383
1.59
5.29
4.7
3.3
1525.27
1387.38
ng/l
0.21
173
1190
5
0
+∞
5.22
1.6
0.0
4.26
—
mg/l
—
5
0
5
0
+∞
5.22
1.6
0.0
1.90
—
mg/l
—
5
0
5
0
+∞
5.22
1.6
0.0
4.73
—
mg/l
—
5
0
5
0
+∞
5.22
1.6
0.0
1.03
—
mg/l
—
5
0
223
1735
1.57
5.19
3.8
2.9
124.79
130.68
ug/l
0.17
205
1601
11
15
7.49
5.17
3.1
6.1
—
—
—
0
0
13
23
5.79
5.10
1.5
1.6
—
—
—
0
0
11
16
7.02
4.98
1.9
1.6
—
—
—
0
0
11
16
7.02
4.98
1.9
1.6
—
—
—
0
0
11
16
7.02
4.98
1.9
1.6
—
—
—
0
0
11
16
7.02
4.98
1.9
1.6
—
—
—
0
0
13
24
5.55
4.95
1.5
1.6
—
—
—
0
0
100
648
1.70
4.87
3.6
3.2
0.73
2.24
e6/l
3.24
55
309
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
28
115
2.53
4.73
2.9
2.3
0.30
0.37
iu/ml
0.78
20
66
189
1439
1.54
4.71
4.9
3.4
2.34
2.35
mmol/l
1.31
179
1302
13
28
4.75
4.40
1.5
1.6
—
—
—
0
0
15
45
3.41
4.36
1.1
1.1
—
—
—
0
0
103
694
1.63
4.28
3.4
3.0
0.46
1.12
e6/l
2.69
58
355
14
34
4.22
4.24
1.1
1.1
—
—
—
0
0
100
675
1.62
4.11
5.0
3.2
0.82
0.81
mmol/l
0.20
95
634
13
34
3.91
3.72
1.6
1.7
—
—
—
0
0
13
34
3.91
3.72
1.2
1.1
—
—
—
0
0
167
1290
1.47
3.66
2.7
2.1
137.36
220.40
u/l
1.91
162
1224
240
1987
1.45
3.65
19.4
14.7
1.28
1.26
inr
0.21
213
1662
48
274
1.84
3.59
1.9
1.7
—
—
—
0
0
7
9
7.88
3.57
1.1
1.6
—
—
—
0
0
11
27
4.15
3.41
1.1
1.1
—
—
—
0
0
12
32
3.82
3.41
1.1
1.1
—
—
—
0
0
12
32
3.82
3.41
1.0
1.0
—
—
—
0
0
36
191
1.96
3.35
1.6
1.8
1.66
1.44
g/l
0.54
30
170
14
48
2.98
3.33
1.2
1.1
2.14
4.11
u/ml
—
7
19
11
28
4.00
3.31
1.1
1.2
—
—
—
0
0
65
416
1.66
3.28
5.6
3.1
3.12
2.14
mmol/l
0.93
58
355
6
7
8.67
3.27
1.2
1.0
0.56
0.18
u/ml
—
6
7
16
60
2.73
3.26
1.1
1.3
—
—
—
0
0
9
19
4.81
3.25
1.4
3.0
521.11
742.95
u/ml
—
9
19
11
29
3.86
3.20
1.1
1.1
—
—
—
0
0
11
29
3.86
3.20
1.1
1.1
—
—
—
0
0
12
35
3.49
3.13
1.8
1.2
—
—
—
0
0
12
35
3.49
3.13
1.8
1.2
—
—
—
0
0
295
2579
1.42
3.08
6.3
4.9
1968.20
1266.96
e6/l
—
5
48
8
16
5.07
3.06
1.0
1.2
—
—
—
0
0
30
155
2.00
3.02
2.6
2.0
149.67
304.28
ug/l
1.58
30
147
61
393
1.64
3.01
2.8
2.3
0.21
0.21
g/l
0.17
56
363
159
1256
1.41
2.97
1.7
1.7
21.10
20.79
nmol/l
0.10
139
1039
21
96
2.25
2.88
1.2
1.2
—
—
—
0
0
133
1034
1.41
2.68
4.1
2.7
352.02
348.76
umol/l
0.13
123
904
5
7
7.21
2.55
1.4
1.7
—
—
—
0
0
29
160
1.87
2.46
2.4
1.8
—
—
—
0
0
391
3663
1.54
2.38
33.2
17.0
23.37
25.20
mg/l
0.60
373
3060
7
17
4.17
2.37
1.0
1.1
—
—
—
0
0
111
858
1.39
2.28
1.5
1.3
0.56
1.40
u/ml
2.06
25
231
5
9
5.60
2.22
2.0
1.6
0.69
0.62
mmol/l
—
5
9
242
2113
1.32
2.19
5.2
4.1
0.00
0.01
estimate
0.50
57
420
6
14
4.33
2.15
1.0
1.1
—
—
—
0
0
238
2079
1.31
2.12
5.1
4.1
0.00
0.00
estimate
-0.00
58
440
240
2103
1.30
2.07
5.2
4.1
0.00
7.70
estimate
0.80
60
455
13
56
2.36
2.06
2.8
2.1
31.00
32.75
pg
0.69
13
56
9
34
2.68
1.87
1.1
1.2
101.67
105.62
pmol/l
—
9
34
156
1305
1.30
1.86
2.9
2.6
57.64
65.30
u/l
0.61
151
1210
210
1826
1.28
1.86
2.4
2.2
96.98
96.35
pmol/l
0.07
108
921
21
116
1.85
1.82
2.3
1.5
—
—
—
0
0
18
95
1.93
1.78
2.6
1.5
—
—
—
0
0
21
117
1.83
1.77
1.3
1.1
—
—
—
0
0
9
36
2.53
1.75
1.0
1.3
—
—
—
0
0
8
30
2.70
1.73
2.3
2.7
13.82
13.19
%
—
8
30
52
371
1.45
1.68
2.8
2.5
25.25
37.00
u/l
2.00
44
303
25
150
1.71
1.67
2.1
1.7
—
—
—
0
0
63
467
1.41
1.66
2.4
2.8
5.62
8.37
umol/l
1.76
58
418
13
64
2.06
1.55
1.2
1.2
—
—
—
0
0
6
21
2.88
1.51
1.0
1.1
—
—
—
0
0
107
874
1.29
1.50
3.0
2.9
2.48
2.46
mmol/l
1.50
99
787
190
1664
1.25
1.50
5.2
4.0
28.10
72.02
ng/l
0.75
144
1248
314
2912
1.26
1.46
4.8
4.3
15.20
14.90
pmol/l
1.31
293
2631
7
28
2.52
1.45
2.1
1.3
—
—
—
0
0
22
133
1.69
1.45
1.5
1.4
243.40
294.90
ug/g
—
10
76
17
95
1.82
1.45
1.7
1.3
—
—
—
0
0
21
126
1.70
1.42
1.4
1.3
—
—
—
0
0
24
150
1.63
1.41
1.3
4.1
41.69
97.05
mg/l
0.76
18
128
10
46
2.20
1.41
2.1
1.3
—
—
—
0
0
7
29
2.44
1.39
1.0
1.2
—
—
—
0
0
6
23
2.63
1.37
1.0
1.8
—
—
—
0
0
6
23
2.63
1.37
1.0
1.8
—
—
—
0
0
18
105
1.74
1.35
2.7
3.2
0.78
1.85
index
—
9
61
10
47
2.15
1.34
1.1
1.4
27440.00
31297.37
e6/l
—
5
27
9
43
2.12
1.31
3.1
2.0
0.11
0.65
mmol/l
—
9
43
19
114
1.70
1.30
3.1
2.6
1.56
1.59
mg/l
0.05
19
96
32
450
0.69
1.23
14.4
7.8
—
—
—
0
0
63
494
1.32
1.20
1.6
1.5
—
—
—
0
0
6
26
2.32
1.19
7.8
3.6
0.83
1.27
%
—
6
26
89
732
1.27
1.19
1.9
1.8
1083.59
1205.83
nmol/l
0.89
72
557
23
150
1.56
1.17
1.3
4.1
31.06
46.43
mg/l
0.52
17
129
19
118
1.64
1.16
1.4
1.1
—
—
—
0
0
0
35
0.00
1.15
0.0
1.1
—
40.52
—
0
24
0
35
0.00
1.15
0.0
1.0
—
666.80
—
0
25
161
1418
1.21
1.14
4.4
3.3
6.53
7.27
mmol/l
1.96
141
1177
8
41
1.97
1.09
1.6
2.3
—
—
—
0
0
31
222
1.43
1.04
1.5
1.4
—
—
—
0
0
26
180
1.47
1.03
1.3
1.3
—
—
—
0
0
15
91
1.67
1.01
2.9
1.8
3.38
4.69
iu/l
—
8
39
129
1125
1.21
1.00
4.3
3.6
0.23
0.01
estimate
0.57
52
349
360
3444
1.23
0.98
6.1
5.4
1.84
1.99
mu/l
1.61
336
3140
16
100
1.62
0.98
1.4
1.5
—
—
—
0
0
7
37
1.91
0.94
1.0
1.6
—
53.33
—
0
6
6
29
2.08
0.89
1.0
1.2
—
—
—
0
0
10
56
1.80
0.88
1.1
1.0
—
—
—
0
0
262
2453
1.16
0.84
4.0
3.2
76.13
50.89
u/l
1.19
255
2292
197
1808
1.16
0.82
3.4
2.7
—
—
estimate
—
0
0
5
100
0.49
0.78
1.0
1.1
1.60
1.55
g/l
—
5
100
335
3481
0.85
0.76
4.7
4.5
1.21
1.28
mmol/l
1.36
313
3175
353
3652
0.84
0.75
5.7
5.4
4.65
4.59
mmol/l
0.45
335
3374
51
417
1.25
0.75
4.3
3.6
—
—
—
0
0
360
3716
0.84
0.73
6.5
6.2
2.62
2.65
mmol/l
0.26
340
3422
7
39
1.81
0.72
1.3
1.4
—
—
—
0
0
10
60
1.68
0.72
4.3
2.8
105.30
105.53
mmol/l
—
10
60
351
3628
0.85
0.71
5.6
5.3
1.60
1.48
mmol/l
5.30
332
3333
5
26
1.93
0.71
1.0
1.0
—
—
—
0
0
9
59
1.54
0.68
4.7
2.8
1.18
1.19
mmol/l
—
9
59
31
243
1.30
0.64
3.1
2.4
0.64
0.61
%
0.24
31
243
16
112
1.44
0.64
1.6
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
9.19
—
0
21
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
171
1584
1.13
0.59
5.2
4.0
0.06
0.03
estimate
0.21
54
361
31
247
1.27
0.58
3.1
2.4
1.13
1.16
%
0.13
31
247
6
36
1.68
0.57
1.2
1.1
—
—
—
0
0
6
39
1.55
0.53
1.2
1.2
—
—
—
0
0
64
558
1.17
0.52
1.6
1.5
—
—
—
0
0
6
98
0.61
0.52
3.7
1.7
52.33
40.77
nmol/l
—
6
92
39
325
1.22
0.52
3.4
2.7
61.16
62.08
ml/min/173m2
0.09
25
134
22
171
1.30
0.51
1.1
1.0
—
—
—
0
0
18
137
1.33
0.48
1.2
3.8
1.40
3.41
ratio
—
10
77
43
502
0.84
0.47
4.7
5.0
35.12
32.39
%
1.07
34
322
55
479
1.17
0.47
3.0
4.4
128.17
40.15
ug/l
0.31
49
400
128
1184
1.11
0.45
5.1
4.2
0.00
0.01
estimate
0.74
53
410
363
3544
1.13
0.43
7.4
6.9
40.28
39.89
mmol/mol
0.34
349
3321
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
365
3569
1.12
0.40
25.9
17.0
75.93
77.10
ml/min/173m2
0.49
356
3331
64
714
0.88
0.40
3.5
3.2
0.68
0.81
ug/l
0.68
47
463
7
102
0.68
0.40
1.3
1.1
0.83
0.91
g/l
—
7
102
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
171.98
—
0
19
149
1404
1.09
0.36
5.2
4.0
4.81
8.41
mg/mmol
1.51
97
853
114
1222
0.91
0.36
5.4
5.6
1.63
2.51
ug/l
2.08
104
1085
44
387
1.15
0.35
1.8
1.8
1.48
1.51
%
0.16
37
333
14
110
1.28
0.32
1.1
1.6
—
—
—
0
0
7
100
0.70
0.31
1.0
1.3
36.23
26.10
iu/l
—
7
86
16
129
1.25
0.30
2.3
2.0
17.66
2.89
mg/l
0.79
16
99
102
953
1.09
0.30
3.4
2.3
—
—
—
0
0
7
55
1.28
0.30
1.0
1.1
—
25.78
—
0
9
7
56
1.25
0.29
6.9
6.5
411.14
357.67
umol/l
—
7
49
15
123
1.23
0.25
1.5
1.3
—
—
—
0
0
11
87
1.27
0.24
3.3
2.0
—
—
—
0
0
18
153
1.18
0.22
2.9
1.5
0.12
0.33
mg/l
—
10
65
357
3620
0.93
0.21
5.5
5.5
5.83
6.03
mmol/l
1.56
334
3311
92
972
0.93
0.21
4.7
4.8
21.77
21.73
%
0.01
42
475
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
1.26
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
39
355
1.11
0.20
2.8
2.5
6.66
7.00
ug/l
0.06
34
314
10
80
1.26
0.20
2.7
2.8
9.87
9.88
pmol/l
—
10
80
13
108
1.21
0.20
3.0
2.0
—
—
—
0
0
167
1614
1.06
0.20
2.2
2.0
1.29
1.32
mmol/l
0.17
139
1350
11
91
1.21
0.17
5.4
2.1
24.82
33.04
umol/l
2.03
11
78
90
865
1.05
0.13
1.7
1.8
420.74
451.11
pmol/l
0.57
78
723
96
928
1.04
0.11
5.7
4.2
1.02
1.02
kg/l
0.56
71
619
6
55
1.09
0.09
1.0
1.6
—
—
—
0
0
11
99
1.11
0.06
1.5
1.7
—
—
—
0
0
22
208
1.06
0.05
2.2
1.8
—
—
—
0
0
10
93
1.08
0.02
1.3
1.4
—
—
—
0
0
23
237
0.97
0.01
1.2
1.2
134.93
137.14
u/ml
0.01
11
92
22
218
1.01
0.00
2.0
3.2
18.18
111.30
u/ml
1.05
22
212
23
229
1.00
0.00
2.6
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
6.94
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
1.19
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint J10_PULMEOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.613 [1.36, 1.91] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.183 |
During the follow-up period (1.1.1998 — 31.12.2019), 276 out of 1053 females with J10_PULMEOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.865 [1.56, 2.23] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 327 out of 857 males with J10_PULMEOS died.
Mortality risk
Mortality risk for people of age
years, who have J10_PULMEOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.372% |
| 5 | 0.928% | 2.274% |
| 10 | 2.312% | 5.463% |
| 15 | 4.365% | 9.521% |
| 20 | 7.696% | 15.863% |
Relationships between endpoints
↥Index endpoint: J10_PULMEOS – Pulmonary eosinophilia, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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