eosinophilic pneumonia: An inflammatory lung disorder characterized by an increased number of eosinophils in the lungs. The majority of cases are idiopathic, without identifiable cause. In a minority of cases, medications, fungal infections, and environmental triggers have been implicated. It manifests as acute or chronic. Acute eosinophilic pneumonia is a severe and rapidly progressing pneumonia that may lead to respiratory failure requiring mechanical ventilation. Chronic eosinophilic pneumonia follows a slower course and manifests as fever, dyspnea, cough, and weight loss.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditionsNone |
519870 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
447 |
4. Check minimum number of eventsNone |
447 |
5. Include endpointsNone |
447 |
6. Filter based on genotype QC (FinnGen only) |
436 |
Control definitions (FinnGen only)
- Control exclude
- J10_INTERSTITIUM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J80-J84
- Name in latin
- Eosinophilia pulmonum non alibi classificata
Similar endpoints
↥List of similar endpoints to
Pulmonary eosinophilia, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3168 | 1780 | 1353 |
| Only index persons | 2462 | 1464 | 998 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 59.21 | 58.03 | 60.60 |
| Only index persons | 56.56 | 55.95 | 57.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 436 | 244 | 192 |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | 57.90 | 54.33 | 62.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 447
- Matched controls
- 4470
TimeCodeWAS
↥TODO / Current known limitations:
- Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
- Legend / how to read the glyphs.
- Proper column names.
- Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
- Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
- Download CSV not working.
- No filters and sorters.
- Limited amount of endpoints with TimeCodeWAS data.
- Cross-links to Risteys lab test pages for lab test codes.
J84.9 (45543277)
386789004 (4304002)
J82 (45548123)
J84.8 (45548126)
5183A (2000404063)
TGC00 (2001303585)
5128-4 (3001334)
6968-2 (3009445)
48404-8 (3049804)
50373000 (4177340)
60621009 (4245997)
J84.1 (45557630)
UGC12 (2001303610)
SMOKING-2-3-0 (2002330113)
29257-3 (3002482)
14278-6 (3003284)
14277-8 (3004383)
23826-1 (3012477)
13956-8 (3014162)
21363-7 (3020565)
34645-2 (3031478)
49774-3 (3032700)
M30.1 (45548401)
R91 (45548995)
J45.0 (45557624)
51920 (2000302925)
GD1DD (2001303632)
Z2221 (2001311556)
R03AC02 (21603256)
ERIP (262)
26484-6 (3001604)
26478-8 (3002030)
19113-0 (3005322)
543-9 (3005702)
26444-0 (3006315)
26450-7 (3006504)
19926-5 (3011505)
26449-9 (3013115)
14749-6 (3013826)
26511-6 (3018010)
26485-3 (3019069)
26474-7 (3019198)
19870-5 (3020158)
1995-0 (3021347)
30180-4 (3022096)
600-7 (3023368)
20150-9 (3024653)
29953-7 (3037522)
43409-2 (3042936)
11 (38004456)
93 (38004510)
57782-5 (40760892)
69738-3 (42870588)
J15.9 (45557621)
J33.0 (45562447)
J45.9 (45562456)
IP (9201)
29 (38004472)
H02AB06 (21602734)
A07EA01 (21600653)
21 (8717)
GD1AA (2001303617)
OP (9202)
J45.1 (45557625)
R03DC03 (21603356)
19875-4 (3001668)
20155-8 (3023550)
69970-2 (42868459)
69982-7 (42868471)
69983-5 (42868472)
R03AK06 (21603280)
1988-5 (3020460)
R03BA02 (21603285)
OMOP5117446 (33004)
OMOP4822458 (581477)
751-8 (3013650)
A02BC02 (21600097)
H02AB04 (21602732)
R03BA05 (21603288)
R03BA09 (45893496)
30385-9 (3002385)
J32.0 (45586667)
4537-7 (3013707)
J01AA02 (21602800)
R03AK08 (43534839)
J01FA06 (21602974)
55429-5 (40758558)
715-3 (3021589)
207NI0002X (38003841)
R01AD08 (21605050)
R01AD12 (21605053)
R03AC03 (21603257)
203 (2001600201)
R03BB04 (21603296)
M05BA04 (21604152)
R01AD09 (21605051)
113016006 (4010399)
ER (9203)
28539-5 (3035941)
26515-7 (3007461)
26453-1 (3026361)
26464-8 (3010813)
30428-7 (3024731)
718-7 (3000963)
OMOP4822462 (581458)
2951-2 (3019550)
20570-8 (3009542)
28540-3 (3003338)
2823-3 (3023103)
J18.9 (45601123)
62238-1 (40764999)
A12AA20 (21600872)
22 (8756)
14682-9 (3020564)
4 (38004449)
14631-6 (3006140)
50554-5 (3029287)
R03BA08 (21603291)
R01AD13 (43534836)
A07EA03 (21600655)
H02AB07 (21602735)
30405-5 (3018095)
58410-2 (40761511)
J01CR02 (21602863)
19072-8 (3016431)
J45 (45596282)
6768-6 (3035995)
J01CA04 (21602823)
OMOP4822461 (32036)
1742-6 (3006923)
J01MA14 (21603021)
1 (38004446)
J20.9 (45562445)
R05CB15 (21603394)
Z01.8 (45581003)
24357-6 (3037467)
J33.8 (45591556)
R06AE07 (21603497)
J01DB01 (21602870)
251B00000X (38004193)
127783003 (4133840)
J01FA10 (21602978)
J01FA09 (21602977)
R05 (45606792)
L04AX01 (21603927)
NK6QA (2001308500)
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint J10_PULMEOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.613 [1.36, 1.91] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.183 |
During the follow-up period (1.1.1998 — 31.12.2019), 276 out of 1053 females with J10_PULMEOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.865 [1.56, 2.23] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 327 out of 857 males with J10_PULMEOS died.
Mortality risk
Mortality risk for people of age
years, who have J10_PULMEOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.372% |
| 5 | 0.928% | 2.274% |
| 10 | 2.312% | 5.463% |
| 15 | 4.365% | 9.521% |
| 20 | 7.696% | 15.863% |
Relationships between endpoints
↥Index endpoint: J10_PULMEOS – Pulmonary eosinophilia, not elsewhere classified
GWS hits: 1