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ILD medications: nintedanib

ILD_NINTENDANIB

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC L01XE31

1 out of 7 registries used, show all original rules.

243

4. Check minimum number of events

Min. number of events 3
243

5. Include endpoints

None

243

6. Filter based on genotype QC (FinnGen only)

188

Control definitions (FinnGen only)

Control exclude
ILD_MEDICATIONS

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 188 54 134
Unadjusted period prevalence (%) 0.05 0.02 0.06
Median age at first event (years) 70.51 71.20 70.22

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
194
Matched controls
1940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L01XE31
ATC
[U] nintedanib
+∞
280.8
194
*
284
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
278.5
194
*
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
+∞
257.2
194
16
356
Kela drug reimbursment
Nintedanib and pirfenidone
8277.5
203.4
159
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
125.3
188.8
99
16
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
52.2
158.8
104
42
L01EX09
ATC
nintedanib; oral
584.9
119.5
107
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
45.0
107.2
68
23
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
34.1
107.1
76
36
L04AX05
ATC
pirfenidone; oral
+∞
103.7
90
*
XG410
NOMESCO Finland
Flow-volume spirometry
31.3
89.7
64
30
UGC12
NOMESCO Finland
Flexible bronchoscopy
17.9
82.7
83
78
TGC00
NOMESCO Finland
Bronchial lavation
33.2
70.8
48
19
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
16.3
58.4
56
47
H02AB06
ATC
prednisolone; systemic
10.5
55.2
145
426
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
24.2
51.6
39
20
GD1AD
NOMESCO Finland
Thorax CT examination
10.3
44.7
60
81
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
8.3
43.2
75
137
GD1AA
NOMESCO Finland
Thorax X-ray examination
12.8
36.8
175
812
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
11.5
34.8
40
43
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
183.3
30.6
31
*
Z51.5
ICD-10 Finland
Palliative care
6.4
30.4
64
138
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.2
29.4
100
328
R03AC02
ATC
salbutamol; inhalant
6.1
29.1
147
661
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
7.7
27.5
44
71
J96.1
ICD-10 Finland
Chronic respiratory failure
32.5
26.9
35
13
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
70.5
26.8
30
5
N02AA01
ATC
morphine; systemic, rectal
25.7
25.9
36
17
R03BA08
ATC
ciclesonide; inhalant
8.1
24.7
37
55
L04AA06
ATC
mycophenolic acid; systemic
+∞
23.4
22
*
R06.0
ICD-10 Finland
Dyspnoea
4.2
21.8
95
360
R05
ICD-10 Finland
Cough
4.5
21.2
69
210
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
123.4
21.0
22
*
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
64.8
20.4
23
*
WX721
NOMESCO Finland
Oxygen concentrator therapy
+∞
20.1
19
*
127
Kela drug reimbursment
Transplant complication
+∞
19.1
18
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
19.1
18
*
Z94.2
ICD-10 Finland
Lung transplant status
+∞
19.1
18
*
R03BB04
ATC
tiotropium bromide; inhalant
5.9
18.7
38
77
R28
ICPC
Limited function/disability (R)
44.2
16.7
20
5
R02
ICPC
Shortness of breath/dyspnoea
4.2
15.7
51
152
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.4
15.3
91
404
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
+∞
14.8
14
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
12.8
68
277
R03AK08
ATC
formoterol and beclometasone; inhalant
14.6
12.8
21
16
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.7
12.6
47
153
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.8
12.2
30
71
R03BA01
ATC
beclometasone; inhalant
4.4
12.0
33
86
J01FA10
ATC
azithromycin; systemic
2.9
11.9
111
614
GX1K5
NOMESCO Finland
Diffusion capacity
69.3
11.8
13
*
GX2C5
NOMESCO Finland
Short-lasting oximetry
127.2
11.6
12
*
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
26.9
11.3
15
6
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
11.3
84
410
N02AA05
ATC
oxycodone; systemic
3.0
11.1
63
265
XG466
NOMESCO Finland
Sleep oxymetry
9.4
10.9
22
26
WX892
NOMESCO Finland
Monitored bed care
4.3
10.8
31
83
GX1D5
NOMESCO Finland
Flow volume spirometry
63.6
10.7
12
*
L04AX01
ATC
azathioprine; systemic
116.0
10.5
11
*
L04AD01
ATC
ciclosporin; systemic
+∞
10.5
10
*
R03AK07
ATC
formoterol and budesonide; inhalant
3.4
10.3
42
144
R05
ICPC
Cough
2.9
9.9
63
280
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.0
9.8
31
89
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.3
9.8
27
70
WX726
NOMESCO Finland
High-flow oxygen therapy
104.9
9.5
10
*
R99
ICPC
Respiratory disease other
11.5
9.5
17
16
L04AD02
ATC
tacrolimus; systemic
+∞
9.4
9
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.6
9.4
82
425
WX725
NOMESCO Finland
Noninvasive ventilation
4.4
9.4
25
63
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.8
9.4
31
92
J01MA14
ATC
moxifloxacin; systemic
4.1
9.3
27
73
J47
ICD-10 Finland
Bronchiectasis
16.6
9.2
14
9
A02BC02
ATC
pantoprazole; systemic
3.0
9.1
154
1092
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
10.2
9.0
17
18
XJC10
NOMESCO Finland
Oesophageal pH monitoring
52.4
8.8
10
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
10.8
8.7
16
16
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
7.3
8.6
20
30
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
7.3
8.6
20
30
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
8.5
8.6
18
23
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
7.7
8.5
19
27
R01AD12
ATC
fluticasone furoate; nasal
2.7
8.4
60
280
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
+∞
8.4
8
*
J01FA06
ATC
roxithromycin; oral
2.4
8.1
86
481
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
23.2
8.1
11
5
R5140
NOMESCO Finland
Monitoring the use of the aid
3.0
8.1
40
153
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.4
7.8
81
447
R4110
NOMESCO Finland
Physiotherapy
2.4
7.5
74
398
J45.9
ICD-10 Finland
Asthma, unspecified
3.1
7.2
34
126
J01CA04
ATC
amoxicillin; systemic
2.7
6.9
159
1214
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
11.5
6.9
12
11
J01MA12
ATC
levofloxacin; systemic
2.5
6.9
50
233
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.2
6.8
102
650
SPAT1262
SPAT
Handing over of treatment supplies
2.5
6.8
53
256
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
6.7
42
182
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
72.1
6.5
7
*
WW200
NOMESCO Finland
Immunization
11.6
6.4
11
10
J84
ICD-10 Finland
Other interstitial pulmonary diseases
+∞
6.3
6
*
GX2D5
NOMESCO Finland
Sleep oximetry
27.7
6.3
8
*
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
7.1
6.2
14
21
XG474
NOMESCO Finland
Exhalation nntrogen oxide
10.5
6.1
11
11
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.9
6.1
18
49

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
115
155
16.76
91.56
1.5
1.2
327.06
484.44
titre
0.36
34
36
60
24
35.75
88.99
3.0
1.6
—
—
—
0
0
98
125
14.82
79.85
4.6
4.5
—
—
—
0
0
42
13
40.96
66.67
1.3
1.2
—
—
—
0
0
47
21
29.22
66.22
1.4
1.2
—
—
—
0
0
41
15
34.39
61.73
5.0
1.6
4.86
4.26
e9/l
0.38
41
15
43
20
27.34
59.43
1.4
1.3
142.31
160.00
au/ml
—
16
5
170
565
17.24
58.80
15.8
3.5
—
—
—
0
0
54
44
16.62
57.18
1.2
1.1
—
—
—
0
0
104
217
9.18
54.51
1.6
1.2
37.10
24.67
iu/ml
0.41
36
60
43
26
20.96
52.93
5.1
1.5
57.38
61.08
%
0.76
43
26
111
256
8.80
52.73
10.9
7.9
2.01
0.70
mmol/l
3.48
101
210
110
258
8.54
51.17
11.0
7.8
7.42
7.41
ph
1.00
81
150
41
25
20.53
50.17
3.8
2.9
—
—
—
0
0
36
19
23.04
46.88
1.1
1.0
2.81
2.63
u/ml
—
26
8
178
767
17.01
43.11
15.1
3.8
58.89
57.21
%
1.15
178
721
37
27
16.70
41.07
3.9
1.2
—
—
—
0
0
37
27
16.70
41.07
3.9
1.2
—
—
—
0
0
37
27
16.70
41.07
3.9
1.2
—
—
—
0
0
37
27
16.70
41.07
3.9
1.2
—
—
—
0
0
72
133
8.02
40.86
4.3
1.4
—
—
—
0
0
49
78
8.07
31.21
1.4
1.3
—
—
—
0
0
45
71
7.95
28.77
1.3
1.1
164.39
218.19
u/ml
0.18
40
65
30
29
12.05
27.83
1.2
1.0
—
—
—
0
0
36
47
9.18
26.88
2.4
2.3
140.42
126.70
g/l
1.20
12
37
55
115
6.28
26.74
5.2
3.5
7.42
7.42
ph
0.06
49
95
127
553
4.75
24.85
5.0
3.9
—
—
—
0
0
142
684
5.01
24.00
4.2
3.2
948.12
1410.78
ng/l
1.32
129
590
68
193
4.89
23.08
1.3
1.2
6.17
2.64
u/ml
0.48
16
65
30
40
8.69
21.87
11.8
2.7
3.40
2.12
mmol/l
1.58
30
23
58
151
5.05
21.75
1.5
1.4
—
—
—
0
0
29
12
28.15
21.59
2.1
1.8
—
—
—
0
0
31
44
8.20
21.45
1.3
1.3
—
—
—
0
0
31
44
8.20
21.45
8.5
2.8
—
—
—
0
0
68
206
4.54
21.04
4.1
1.3
—
—
—
0
0
30
18
19.47
19.93
1.1
1.0
350.75
256.09
u/ml
0.56
24
11
25
9
31.59
19.27
1.2
1.1
—
—
—
0
0
50
127
4.96
19.13
1.4
1.4
—
—
—
0
0
51
135
4.77
18.52
1.5
1.3
—
—
—
0
0
50
136
4.61
17.48
5.5
3.0
0.48
0.69
%
0.42
30
39
37
80
5.48
16.93
5.2
3.4
—
—
—
0
0
48
130
4.58
16.83
5.4
3.0
0.79
0.38
%
0.46
28
39
83
350
3.40
15.18
2.6
1.5
1.52
1.33
mg/l
0.22
74
281
155
964
4.02
14.75
13.2
6.8
1.20
1.20
mmol/l
0.29
134
825
45
132
4.14
14.06
4.8
3.0
0.04
0.17
%
0.71
23
35
74
310
3.24
13.41
12.4
3.4
—
—
—
0
0
110
581
3.06
13.24
6.2
3.7
7.41
7.40
ph
2.47
92
404
17
8
23.12
12.24
1.4
1.0
—
—
—
0
0
68
286
3.12
12.06
1.9
1.3
3.17
2.88
g/l
0.51
52
152
42
140
3.55
10.76
3.1
3.5
—
—
—
0
0
125
769
2.76
10.38
23.9
10.3
0.00
0.00
e9/l
1.30
117
608
42
145
3.42
10.17
5.3
3.2
0.05
0.16
%
0.42
21
37
104
590
2.64
10.08
4.4
2.0
121.50
324.83
u/l
1.01
98
560
53
213
3.05
9.97
4.4
2.4
9.72
11.83
umol/l
0.34
53
194
70
333
2.72
9.59
3.0
1.8
28.26
29.48
s
2.14
70
326
99
561
2.56
9.45
4.5
3.2
0.43
0.48
e6/l
0.13
83
402
20
26
8.44
9.41
1.3
1.0
—
—
—
0
0
144
979
2.83
9.37
10.9
15.5
1.22
1.31
inr
1.40
126
808
18
20
9.80
9.26
2.4
1.4
87.89
89.59
%
0.35
18
20
78
409
2.52
8.60
4.9
3.8
1501.23
519.38
ng/l
1.12
69
356
92
532
2.39
8.07
11.9
5.6
—
—
—
0
0
13
10
13.82
8.00
1.0
1.0
—
—
—
0
0
105
645
2.37
7.99
5.0
3.4
38.57
35.98
e6/l
0.05
87
485
11
6
19.32
7.69
2.9
1.8
23.64
58.12
ug/l
—
11
6
13
12
11.51
7.41
3.1
2.2
19.31
15.96
%
1.57
13
12
21
59
3.87
6.80
1.4
1.2
—
—
—
0
0
78
447
2.25
6.71
8.4
2.7
365.88
367.50
umol/l
0.05
69
371
63
331
2.34
6.65
4.4
3.3
0.51
0.95
e6/l
0.73
37
175
107
699
2.18
6.61
6.7
3.9
27.85
110.48
e6/l
1.85
87
492
115
774
2.19
6.57
4.4
4.0
41.15
39.05
ng/l
0.05
100
626
48
225
2.51
6.50
1.1
1.3
—
—
—
0
0
12
13
9.75
6.38
1.1
1.0
—
—
—
0
0
9
5
18.77
6.32
1.1
1.0
—
—
—
0
0
6
0
+∞
6.28
1.5
0.0
120.33
—
e6/l
—
6
0
35
143
2.77
6.22
2.2
1.7
170.62
138.31
ug/g
0.34
29
113
11
11
10.52
6.11
1.6
1.5
—
—
—
0
0
40
188
2.42
5.32
20.5
8.9
—
—
—
0
0
5
0
+∞
5.23
1.6
0.0
9.60
—
%
—
5
0
5
0
+∞
5.23
1.4
0.0
19.40
—
%
—
5
0
52
276
2.21
5.22
4.6
1.8
—
—
—
0
0
16
45
3.79
5.16
1.4
1.4
218.80
280.21
ug/g
—
10
28
164
1336
2.47
5.11
43.1
21.4
14.28
13.77
%
4.46
164
1319
57
329
2.04
4.55
2.2
2.5
12.01
13.26
umol/l
0.70
57
300
92
641
1.83
4.09
6.1
3.7
2.34
2.35
mmol/l
0.22
87
571
72
469
1.85
3.95
2.0
1.3
—
—
—
0
0
63
394
1.89
3.92
2.1
1.8
480.73
18038425.87
pmol/l
0.50
52
316
50
293
1.95
3.76
2.1
2.4
21.36
24.07
%
0.85
50
273
6
6
10.26
3.52
1.0
1.0
—
—
—
0
0
6
6
10.26
3.52
1.0
1.0
—
—
—
0
0
6
6
10.26
3.52
1.0
1.0
—
—
—
0
0
80
554
1.76
3.50
2.8
3.0
—
—
—
0
0
36
194
2.05
3.40
2.0
2.2
79.37
67.39
e9/l
0.76
23
145
117
928
1.66
2.92
5.1
3.8
0.00
1.78
estimate
0.51
37
171
115
909
1.65
2.90
5.2
3.7
0.00
0.00
estimate
-0.00
39
186
116
921
1.65
2.86
5.2
3.8
0.00
9.63
estimate
0.50
38
195
74
529
1.64
2.75
4.3
3.8
0.00
0.00
estimate
-0.00
36
167
10
36
2.87
2.17
1.3
1.1
—
—
—
0
0
0
55
0.00
2.10
0.0
4.6
—
—
—
0
0
169
1532
1.80
2.03
5.2
4.9
2.01
2.10
mu/l
0.50
153
1348
22
120
1.94
2.02
3.5
3.1
24.61
23.95
mmol/l
0.26
22
120
9
33
2.81
1.96
1.3
1.3
61.67
60.04
mmol/l
—
9
28
89
713
1.46
1.81
4.5
3.4
6.03
6.20
ph
0.99
48
402
179
1664
1.98
1.79
5.9
6.0
6.00
6.19
mmol/l
1.78
157
1486
33
213
1.66
1.77
3.8
3.3
7.38
7.39
ph
0.48
18
114
6
19
3.22
1.67
3.3
1.8
-0.02
1.38
mmol/l
—
6
19
23
137
1.77
1.64
2.1
2.4
329.00
405.11
nmol/l
1.19
23
130
181
1698
1.98
1.61
6.1
6.9
2.55
2.52
mmol/l
0.17
161
1533
11
50
2.27
1.60
3.9
2.8
35.73
36.80
umol/l
0.05
11
45
19
108
1.84
1.57
1.1
1.3
—
—
—
0
0
5
15
3.39
1.53
1.0
1.0
—
—
—
0
0
5
15
3.39
1.53
1.2
1.1
—
—
—
0
0
140
1246
1.44
1.48
4.1
3.8
15.03
15.03
pmol/l
0.01
129
1076
5
16
3.18
1.44
3.4
3.3
—
—
—
0
0
5
17
2.99
1.36
1.0
1.0
—
—
—
0
0
45
335
1.45
1.30
1.3
1.3
1.23
1.50
u/ml
0.17
11
85
79
652
1.36
1.25
2.4
2.2
—
—
—
0
0
83
692
1.35
1.23
4.7
3.8
0.00
0.00
estimate
-0.00
36
156
23
150
1.61
1.21
1.3
1.3
—
—
—
0
0
89
753
1.34
1.18
3.5
3.4
7.23
7.92
mmol/l
0.94
73
623
61
487
1.37
1.18
4.0
3.5
0.00
0.17
estimate
0.50
32
150
175
1652
1.61
1.15
5.3
5.8
1.38
1.39
mmol/l
0.11
153
1478
90
766
1.33
1.14
4.2
4.2
6.30
10.11
mg/mmol
0.71
60
493
88
749
1.32
1.11
3.5
3.5
48.51
62.93
mg/l
0.29
64
500
57
457
1.35
1.07
4.8
3.0
—
0.00
—
0
13
169
1590
1.49
1.05
4.6
4.9
1.31
1.28
mmol/l
0.26
148
1411
174
1647
1.55
1.04
6.9
7.7
40.58
40.54
mmol/mol
0.03
157
1519
5
22
2.31
1.04
1.0
1.6
9.72
11.13
%
—
5
22
16
99
1.67
1.03
2.1
2.5
—
—
—
0
0
175
1660
1.55
1.02
5.4
5.9
4.36
4.37
mmol/l
0.05
153
1515
28
201
1.46
0.98
3.9
3.3
2.05
1.47
mmol/l
0.17
22
168
7
36
1.98
0.98
1.7
1.5
32.97
31.19
g/l
—
7
29
43
539
0.74
0.95
2.7
3.9
—
—
—
0
0
6
27
2.26
0.94
1.3
1.3
—
—
—
0
0
6
28
2.18
0.92
1.7
1.4
—
—
—
0
0
8
43
1.90
0.88
2.0
1.2
—
—
—
0
0
45
360
1.33
0.85
2.1
1.7
988.79
1146.19
nmol/l
0.68
35
267
96
850
1.26
0.82
4.4
2.6
—
—
estimate
—
0
0
28
210
1.39
0.79
3.6
3.3
5.87
5.60
kpa
0.58
28
203
0
27
0.00
0.78
0.0
3.2
—
4.04
—
0
27
0
27
0.00
0.78
0.0
3.2
—
1.18
—
0
27
0
27
0.00
0.78
0.0
3.2
—
104.81
—
0
27
52
616
0.79
0.74
2.6
3.6
0.59
0.81
ug/l
2.02
38
437
26
196
1.38
0.72
3.0
2.3
12.03
12.92
nmol/l
0.26
26
173
72
627
1.24
0.69
1.9
1.6
19.45
21.24
nmol/l
0.46
64
505
28
216
1.35
0.68
1.2
1.3
—
—
—
0
0
18
129
1.44
0.66
1.6
2.0
—
—
—
0
0
24
182
1.36
0.65
2.2
1.5
—
—
—
0
0
17
122
1.43
0.62
2.0
2.5
1.40
1.21
%
0.49
17
122
0
23
0.00
0.58
0.0
3.5
—
2.20
—
0
16
0
23
0.00
0.58
0.0
4.6
—
55.61
—
0
23
14
98
1.46
0.58
1.1
1.2
—
—
—
0
0
67
750
0.84
0.53
2.1
2.0
1.54
1.29
mmol/l
1.05
54
593
10
68
1.50
0.48
1.1
1.1
—
—
—
0
0
24
193
1.28
0.46
1.8
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
2.4
—
2.87
—
0
15
0
15
0.00
0.41
0.0
1.1
—
149.09
—
0
15
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
26.73
—
0
11
0
17
0.00
0.41
0.0
1.1
—
268.90
—
0
10
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
0.19
—
0
14
20
162
1.26
0.37
3.1
2.9
0.56
0.36
e6/l
0.22
20
157
7
99
0.70
0.31
1.7
2.5
—
17.96
—
0
8
12
93
1.31
0.30
3.3
1.8
—
—
—
0
0
110
1045
1.12
0.30
4.0
6.3
1.63
2.68
ug/l
2.27
96
925
8
106
0.74
0.30
3.9
3.1
—
—
—
0
0
7
57
1.24
0.29
1.6
2.5
60.26
58.48
%
—
7
57
0
11
0.00
0.21
0.0
1.2
—
8.13
—
0
11
0
10
0.00
0.21
0.0
2.7
—
0.90
—
0
10
5
43
1.17
0.21
3.8
3.6
0.88
0.77
nmol/l
—
5
37
7
61
1.15
0.17
1.0
1.1
—
—
—
0
0
7
88
0.79
0.15
1.0
1.3
—
50.35
—
0
8
21
231
0.90
0.13
1.3
1.3
—
—
—
0
0
16
179
0.88
0.13
1.9
2.8
5.04
4.63
kpa
0.28
16
171
9
84
1.07
0.07
3.1
2.5
—
0.00
estimate
—
0
21
11
121
0.90
0.06
2.2
2.4
0.48
0.64
%
0.99
11
121
10
93
1.08
0.02
3.4
3.4
24.91
24.77
mmol/l
—
10
88
40
408
0.98
0.01
6.6
4.0
1.02
1.02
kg/l
0.10
31
283
14
136
1.03
0.00
3.3
3.1
—
—
—
0
0
23
226
1.02
0.00
1.6
5.7
13.08
39.46
ug/l
0.58
18
189
61
606
1.01
0.00
2.8
2.2
—
—
—
0
0
89
885
1.01
0.00
2.2
2.2
93.93
93.87
pmol/l
0.00
49
437
5
57
0.87
0.00
7.0
12.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.7
1.5
—
16.89
—
0
10
0
5
0.00
-0.00
0.0
1.8
—
9.94
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
169.71
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
9.22
—
0
5
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
9.14
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
6.84
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
1294.67
—
0
6
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ILD_NINTENDANIB – ILD medications: nintedanib

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).