Kyphoscoliotic heart disease

I9_KYPHOSCOLIOTIC_HEART_DISEASE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I27.1 Cause of death: ICD-10 — I27.1 2 out of 7 registries used, show all original rules.	52
4. Check minimum number of events None	52
5. Include endpoints None	52
6. Filter based on genotype QC (FinnGen only)	47

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

NAME	I9_KYPHOSCOLIOTIC_HEART_DISEASE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I271
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I271
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Kyphoscoliotic heart disease based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	47	31	16
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	62.83	60.78	66.81

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3027945) Reticulocytes/Erythrocytes in Blood

5.74

7.40

3.8

3.4

2.39

1.97

0.60

(3019977) pH of Arterial blood

4.50

5.56

13.1

7.3

7.45

7.42

1.50

(3019060) Gas panel - Arterial blood

5.89

5.06

9.7

5.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

3.78

4.88

2.3

1.8

1.21

1.89

mg/l

0.46

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

8.06

4.75

3.4

1.8

95.50

97.00

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

8.06

4.75

4.0

2.1

—

(42870588) Differential panel, method unspecified - Blood

142

3.55

4.52

12.4

5.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

13.30

4.42

2.3

1.5

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

4.05

4.16

2.8

2.6

6.28

5.64

kpa

0.76

(44790048) Parainfluenza type 2 nucleic acid detection

11.39

4.15

3.1

1.1

—

(44790049) Parainfluenza type 3 nucleic acid detection

11.39

4.15

3.1

1.1

—

(44806118) Parainfluenza type 4 nucleic acid detection

11.39

4.15

3.1

1.1

—

(44790047) Parainfluenza type 1 nucleic acid detection

11.39

4.15

3.1

1.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.76

4.10

3.8

1.8

—

(3019198) Lymphocytes [#/volume] in Blood

220

3.78

4.09

10.4

6.3

1.50

1.80

e9/l

1.27

196

(3001604) Monocytes [#/volume] in Blood

221

3.75

4.04

10.2

6.2

0.54

0.59

e9/l

0.55

192

(3006315) Basophils [#/volume] in Blood

221

3.75

4.04

10.3

6.2

0.04

e9/l

0.33

192

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.43

4.04

3.4

1.9

—

(3013115) Eosinophils [#/volume] in Blood

224

3.66

3.89

11.0

6.3

0.18

0.19

e9/l

0.09

195

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.61

3.87

3.5

1.6

—

(4195642) Thrombophilia screening test

13.39

3.87

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

3.29

3.78

8.3

6.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

238

3.66

3.70

16.1

11.3

4.30

4.07

e9/l

0.22

207

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

7.11

3.67

3.0

1.8

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

3.35

3.60

10.5

6.5

102.35

103.90

mmol/l

0.53

(3023419) Bacteria identified in Sputum by Culture

11.15

3.60

2.5

4.3

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

6.59

3.50

3.5

1.7

233.50

243.07

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

6.14

3.35

2.6

1.5

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

6.14

3.35

3.0

1.7

—

(40768797) Stomach Pathology biopsy report

3.17

3.19

1.4

1.3

—

(3000991) Gas panel - Venous blood

3.84

3.13

9.8

6.8

—

(3014007) Fractional oxyhemoglobin in Arterial blood

4.38

3.09

10.2

10.3

92.51

94.94

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

10.92

3.04

3.4

1.8

—

(3017181) Myelocytes/Leukocytes in Blood

3.87

2.96

4.2

5.1

1.10

0.80

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

7.40

2.96

1.3

2.0

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

4.55

2.94

4.1

2.8

126.33

132.26

g/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

5.09

2.94

4.0

2.6

0.99

1.17

—

(3023368) Bacteria identified in Blood by Culture

128

2.71

2.90

7.8

4.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

4.35

2.84

1.9

2.3

24.78

24.40

mmol/l

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

9.09

2.81

1.2

1.0

103.40

109.17

—

(3042936) Bacteria identified in Isolate by Culture

2.99

2.80

3.2

1.9

—

(3002179) Metamyelocytes/Leukocytes in Blood

3.92

2.79

4.3

5.3

1.60

0.54

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

220

2.78

2.75

14.0

6.2

1.18

1.21

mmol/l

1.43

190

(3022313) Gas panel - Capillary blood

4.56

2.70

4.6

2.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.73

2.65

2.1

1.2

2.23

2.52

g/l

0.30

(3025159) Blasts/Leukocytes in Blood

3.66

2.62

4.1

6.0

0.00

0.08

—

(3019230) Fractional oxyhemoglobin in Venous blood

7.78

2.61

6.8

2.6

54.00

61.00

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

3.43

2.45

11.0

7.3

1.47

1.24

mmol/l

—

(3024354) Oxygen [Partial pressure] in Venous blood

3.32

2.37

2.4

2.8

2.60

4.66

kpa

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

4.35

2.35

2.7

2.4

0.79

0.74

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

4.11

2.24

3.9

3.1

26.57

25.55

mmol/l

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

3.21

2.13

11.8

7.3

24.80

25.20

mmol/l

—

(3024928) Oxygen saturation in Venous blood

5.42

2.12

1.6

3.0

55.16

67.29

—

(3037522) Nuclear Ab [Titer] in Serum

2.57

2.06

1.7

1.4

1554.29

632.38

titre

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.71

2.05

3.0

3.6

31.10

46.58

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.33

2.04

15.0

8.8

25.86

25.01

mmol/l

—

(3020891) Body temperature

3.87

1.90

4.3

4.9

37.00

36.90

°c

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

4.15

1.76

1.2

1.3

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.85

1.66

3.4

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.15

1.61

3.2

2.3

—

(3021589) Normoblasts [#/volume] in Blood

185

2.02

1.57

18.6

11.7

0.00

e9/l

0.50

149

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

154

1.93

1.39

4.0

2.4

66.83

52.59

u/l

1.20

145

(3026008) Bacteria identified in Urine by Culture

155

1.91

1.36

3.5

2.9

—

(3002582) Erythrocytes [#/volume] in Urine

166

1.87

1.29

4.6

3.2

8.79

30.33

e6/l

1.28

128

(3000492) Spirometry study

2.38

1.28

2.3

1.4

—

(3000494) Fungus identified in Specimen by Culture

2.26

1.27

3.9

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.25

1.22

1.0

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.25

1.22

2.9

1.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.03

1.21

2.7

2.9

3.00

2.44

e6/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

169

1.82

1.20

5.2

3.2

—

(3044640) Blood type and Crossmatch panel - Blood

134

1.83

1.17

3.8

2.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.41

1.06

1.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.41

1.06

2.2

1.2

—

(40758558) Short blood count panel - Blood

132

1.72

0.95

7.1

7.0

—

(3018095) Leukocytes [#/volume] in Urine

182

1.62

0.85

5.8

4.2

210.19

36.89

e6/l

0.62

129

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.79

0.83

1.5

1.4

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.81

0.0

1.2

—

0.30

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

194

1.59

0.79

3.8

2.8

—

estimate

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

195

1.58

0.77

2.4

2.3

92.38

94.90

pmol/l

—

(3030467) Casts [#/volume] in Urine by Automated count

139

1.60

0.76

5.1

2.9

1.08

0.41

e6/l

0.46

102

(1761868) Lipid panel - Serum or Plasma

151

0.58

0.76

2.8

3.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.69

0.68

14.3

10.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.80

0.65

2.0

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

374

0.64

0.65

8.8

7.0

53.49

40.69

mmol/mol

0.52

349

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.65

0.58

1.4

—

(40768804) Tissue Pathology biopsy report

185

0.66

0.58

2.4

2.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.55

0.51

2.5

2.7

1.67

0.48

e6/l

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.47

0.47

1.9

1.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

280

1.41

0.47

7.2

3.4

77.38

51.60

u/l

0.99

268

(36660697) Celiac disease serology panel - Serum

1.62

0.44

1.2

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.62

0.44

1.6

1.3

—

(36304419) Bacteria [Presence] in Urine

135

1.40

0.43

5.5

2.8

—

estimate

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.4

—

1.67

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.42

0.0

1.1

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.42

0.0

2.7

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.4

—

0.79

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.42

0.0

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.40

0.0

1.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.46

0.40

1.3

17.40

20.44

iu/ml

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

0.63

0.39

1.0

1.3

—

11.00

—

(3003694) ABO and Rh group [Type] in Blood

108

0.69

0.33

1.4

—

(3022145) Colonoscopy Study observation

1.37

0.32

1.6

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.28

0.27

1.4

1.8

—

(40761511) CBC panel - Blood by Automated count

408

1.44

0.26

46.0

14.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

136

1.26

0.24

7.6

3.5

0.00

estimate

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.4

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

0.17

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

1.5

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.26

0.21

4.5

1.5

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.1

—

3.89

—

(40768793) Breast Pathology biopsy report

0.00

0.20

0.0

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

139

1.22

0.19

7.1

4.3

0.00

estimate

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

179

1.20

0.18

7.8

4.2

0.00

estimate

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.15

0.10

5.4

3.4

23.00

29.28

u/l

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.15

0.09

8.7

4.8

39.67

35.33

—

(3002256) Pathology report gross observation

0.83

0.09

1.2

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

0.88

0.07

3.0

2.7

2.44

2.48

mmol/l

—

(3035350) Ketones [Presence] in Urine by Test strip

242

0.91

0.07

7.6

4.3

0.00

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

239

0.93

0.03

7.0

4.2

0.00

estimate

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

227

0.94

0.01

3.4

3.2

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

384

1.08

0.01

37.5

17.9

76.79

78.18

ml/min/173m2

0.14

357

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

151

0.99

0.00

1.8

2.1

1.13

1.31

mmol/l

—

121

(3013512) EKG study

154

0.96

0.00

6.2

4.1

—

(3009261) Glucose [Presence] in Urine by Test strip

242

0.98

0.00

7.1

4.4

0.00

estimate

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

413.77

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.5

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.5

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

2.8

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

2.9

—

92.06

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.9

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

-0.00

0.0

1.3

—

(3022621) pH of Urine by Test strip

1.02

-0.00

3.4

2.3

6.40

5.93

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.7

—

77.43

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

3.72

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: I9_KYPHOSCOLIOTIC_HEART_DISEASE – Kyphoscoliotic heart disease

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Kyphoscoliotic heart disease

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Kyphoscoliotic heart disease (I9_KYPHOSCOLIOTIC_HEART_DISEASE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Relationships between endpoints