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Hypertension, Pulmonary Arterial

DOID EFO Endpoint Browser PheWeb

I9_HYPTENSPUL

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I27.0
  • Hospital discharge: ICD-9 — 4160A
  • Hospital discharge: ICD-8 — 42600
  • Cause of death: ICD-10 — I27.0
  • Cause of death: ICD-9 — 4160A
  • Cause of death: ICD-8 — 42600

2 out of 7 registries used, show all original rules.

333

4. Check minimum number of events

None

333

5. Include endpoints

None

333

6. Filter based on genotype QC (FinnGen only)

319

Control definitions (FinnGen only)

Control exclude
I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I27
Name in latin
Hypertensio pulmonalis primaria

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2950 1579 1316
Only index persons 1759 1100 659
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.03 0.04 0.03
Median age at first event (years)
Whole population 65.26 67.03 63.32
Only index persons 68.00 69.52 65.46

-FinnGen-

Key figures

All Female Male
Number of individuals 319 207 112
Unadjusted period prevalence (%) 0.07 0.07 0.05
Median age at first event (years) 61.78 60.58 63.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
333
Matched controls
3330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
303.4
307.7
159
10
I27.0
ICD-10 Finland
Primary pulmonary hypertension
+∞
307.7
311
*
G04BE03
ATC
sildenafil; oral
186.2
272.6
134
12
205
Kela drug reimbursment
Chronic hypertension
+∞
225.5
190
*
C03DA01
ATC
spironolactone; oral
21.1
173.9
170
157
B01AA03
ATC
warfarin; systemic
14.6
141.9
200
310
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
14.2
138.2
193
294
C03CA01
ATC
furosemide; systemic
16.0
131.3
260
606
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
491.6
107.9
102
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
15.0
107.2
112
109
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
217.9
106.3
105
7
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
10.6
106.0
174
311
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
52.7
97.6
57
13
C02KX04
ATC
macitentan; oral
+∞
89.7
82
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
8.6
87.6
178
392
I50.9
ICD-10 Finland
Heart failure, unspecified
9.2
84.3
137
235
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
8.7
80.3
137
247
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
15.1
79.2
77
65
R06.0
ICD-10 Finland
Dyspnoea
6.9
70.4
194
557
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
11.6
70.3
82
91
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.0
68.8
78
83
C01AA05
ATC
digoxin; systemic
9.0
65.9
97
145
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
262.9
64.6
64
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
12.5
63.0
68
67
J96.1
ICD-10 Finland
Chronic respiratory failure
19.2
62.1
51
31
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.7
61.8
261
1069
I50.0
ICD-10 Finland
Congestive heart failure
9.5
59.6
81
109
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
20.4
57.8
46
26
WX872
NOMESCO Finland
Intensive care
13.5
53.8
54
47
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
14.2
52.5
51
42
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
11.9
51.9
57
57
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
14.2
51.6
50
41
A12BA01
ATC
potassium chloride; oral
23.0
49.4
37
18
C02KX01
ATC
bosentan; oral
+∞
44.8
42
*
G04BE08
ATC
tadalafil; oral
252.5
44.1
44
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
7.5
43.6
71
116
M04AA01
ATC
allopurinol; systemic
6.6
43.6
82
156
I48
ICD-10 Finland
Atrial fibrillation and flutter
4.8
41.1
131
395
C08CA02
ATC
felodipine; oral
11.6
40.4
44
43
WX740
NOMESCO Finland
Nitrogen oxide therapy
151.0
38.6
40
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
13.8
38.2
37
30
GD1AD
NOMESCO Finland
Thorax CT examination
8.0
37.7
56
82
AN1
HP
Coronary angiography
6.6
37.1
68
125
I10
ICD-10 Finland
Essential (primary) hypertension
4.0
35.0
180
754
TPH04
NOMESCO Finland
Cathetrisation of vein
4.4
34.2
119
377
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
7.9
33.6
50
73
AP2
HP
Catheterization of the right side of the heart
100.6
33.5
36
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
129.9
33.4
35
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.3
32.8
79
186
C08CA05
ATC
nifedipine; systemic
9.4
32.4
41
49
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
7.3
32.2
51
80
C07AB07
ATC
bisoprolol; oral
3.8
31.2
205
989
R4110
NOMESCO Finland
Physiotherapy
3.8
30.5
146
572
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
330.9
30.3
30
*
Z3226
NOMESCO Finland
Physiotherapist
4.2
30.3
106
334
ZXE40
NOMESCO Finland
More than seven and less than nine hours
13.1
30.3
30
25
XF404
NOMESCO Finland
Ambulatory ECG
5.9
30.0
60
119
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.7
29.7
144
567
383
Kela drug reimbursment
Selexipag
+∞
29.6
28
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.9
28.2
41
58
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.4
27.8
86
246
C08CA01
ATC
amlodipine; oral
3.7
27.7
126
472
TPH07
NOMESCO Finland
Cathetrisation of artery
5.1
27.7
66
153
B01AC27
ATC
selexipag; oral
+∞
27.5
26
*
C02KX02
ATC
ambrisentan; oral
+∞
27.5
26
*
Z2446
NOMESCO Finland
Social worker
6.3
27.2
50
91
H02AB06
ATC
prednisolone; systemic
3.5
27.2
204
1042
C08DB01
ATC
diltiazem; oral
8.5
26.4
36
47
B01AC11
ATC
iloprost; inhalant, parenteral
+∞
26.4
25
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
25.5
78
220
C09AA02
ATC
enalapril; systemic
4.6
25.2
70
183
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.5
24.7
43
74
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.7
24.5
103
363
XF400
NOMESCO Finland
ECG with 12 standard connections
3.9
24.1
89
287
B01AB05
ATC
enoxaparin; parenteral
3.3
24.1
143
624
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.3
24.0
134
563
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
7.5
23.8
36
53
103
Kela drug reimbursment
Diabetes, insulin-treated
3.6
23.7
100
352
ZXE30
NOMESCO Finland
More than five and less than seven hours
6.8
23.4
39
64
Z94.2
ICD-10 Finland
Lung transplant status
+∞
23.2
22
*
L04AA06
ATC
mycophenolic acid; systemic
28.3
23.1
31
12
R04.0
ICD-10 Finland
Epistaxis
5.2
23.1
52
114
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
246.2
22.9
23
*
A46
ICD-10 Finland
Erysipelas
4.0
22.9
78
237
ZXE20
NOMESCO Finland
More than three and less than five hours
4.0
22.8
76
227
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.7
22.8
90
303
TGC00
NOMESCO Finland
Bronchial lavation
9.7
22.4
27
30
XG466
NOMESCO Finland
Sleep oxymetry
9.7
22.4
27
30
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
8.7
22.1
29
36
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.7
22.0
56
136
ZX120
NOMESCO Finland
Intravenous
4.3
21.5
63
171
K93
ICPC
Pulmonary embolism
53.8
21.4
25
5
TFP20
NOMESCO Finland
Cardiodefibrillation
5.7
21.3
43
85
334
Kela drug reimbursment
Treprostinil
+∞
21.1
20
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
5.2
21.0
47
102
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.7
20.5
53
130
B01AC21
ATC
treprostinil; parenteral
+∞
20.0
19
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
20.0
19
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
7.2
19.9
31
47
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.4
19.9
92
340
K78
ICPC
Atrial fibrillation/flutter
4.8
19.8
49
116
Z3231
NOMESCO Finland
Registered nurse
3.0
19.6
119
515
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
5.7
19.6
39
76
WX892
NOMESCO Finland
Monitored bed care
5.4
19.5
41
84
Z2221
NOMESCO Finland
Medical doctor
3.0
19.5
122
537
XF620
NOMESCO Finland
Examination of circulation with color method
49.2
19.5
23
5
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.9
19.2
64
190
207
Kela drug reimbursment
Chronic arrhythmias
3.4
19.0
81
284
XG410
NOMESCO Finland
Flow-volume spirometry
6.6
18.9
32
53
C02KX05
ATC
riociguat; oral
+∞
18.9
18
*
GD2SN
NOMESCO Finland
Lung ventilation SPECT
41.0
18.8
23
6
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
200.8
18.7
19
*
127
Kela drug reimbursment
Transplant complication
46.9
18.5
22
5
A10AB05
ATC
insulin aspart; parenteral
6.0
18.3
34
62
C07AB02
ATC
metoprolol; systemic
3.3
17.5
79
286
A10BB01
ATC
glibenclamide; oral
8.0
17.2
24
32
M10.9
ICD-10 Finland
Gout, unspecified
5.7
16.9
33
63
S97
ICPC
Chronic ulcer skin
5.4
16.8
35
71
I27.1
ICD-10 Finland
Kyphoscoliotic heart disease
+∞
16.8
16
*
SPAT1262
SPAT
Handing over of treatment supplies
3.4
16.1
68
235
R28
ICPC
Limited function/disability (R)
18.4
15.9
24
14
42600
ICD-8 Finland
Pulmonary heart disease, Cor pulmonale
+∞
15.7
15
*
62
HP
Catheterization and pressure measurement of the right side of the heart
89.4
15.7
17
*
B01AB10
ATC
tinzaparin; parenteral
3.6
15.7
58
184
A10BB12
ATC
glimepiride; oral
5.6
15.6
31
60
C03AA03
ATC
hydrochlorothiazide; oral
5.6
15.6
31
60
J01MA12
ATC
levofloxacin; systemic
3.0
15.4
84
338
I50.1
ICD-10 Finland
Left ventricular failure
5.2
15.3
33
69
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
15.0
98
433
K99
ICPC
Cardiovascular disease other
17.5
15.0
23
14
C02AC05
ATC
moxonidine; oral
59.5
14.9
17
*
AP3
HP
Catheterization of the right and left side of the heart
59.5
14.9
17
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
6.5
14.9
25
41
L04AX01
ATC
azathioprine; systemic
6.0
14.9
27
48
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
+∞
14.7
14
*
GD1UN
NOMESCO Finland
Lung circulation SPECT
37.9
14.6
18
5
FB1BC
NOMESCO Finland
Extensive angiography of arteria pulmonalis
156.6
14.6
15
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.8
14.3
27
50
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.0
14.0
75
297
ZXD05
NOMESCO Finland
Urgent procedure
2.5
13.7
118
594
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
10.7
13.7
26
26
A10BH05
ATC
linagliptin; oral
6.2
13.7
24
41
L04AD02
ATC
tacrolimus; systemic
78.4
13.7
15
*
FBB20
NOMESCO Finland
Thrombendarterectomy of pulmonary artery in chronic obstruction
+∞
13.6
13
*
K82
ICPC
Pulmonary heart disease
+∞
13.6
13
*
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
22.3
13.5
19
9
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.5
13.4
27
53
R5140
NOMESCO Finland
Monitoring the use of the aid
3.5
13.4
50
159
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.2
13.4
60
214
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
17.6
13.1
20
12
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
17.6
13.1
20
12
C09BA02
ATC
enalapril and diuretics; systemic
6.5
13.1
22
36
ZX108
NOMESCO Finland
Inhalation
20.1
13.1
19
10
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.7
13.0
45
136
I20.99
ICD-10 Finland
Angina pectoris, unspecified
4.6
13.0
32
75
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.1
13.0
38
102
R50.9
ICD-10 Finland
Fever, unspecified
2.9
12.8
72
292
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.5
12.8
47
148
B01AB04
ATC
dalteparin; parenteral
4.7
12.7
30
68
3AC01, ,
NOMESCO Finland
25.5
12.6
17
7
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
12.6
12
*
GD1FN
NOMESCO Finland
Lung ventilation isotope imaging
134.9
12.5
13
*
A10AE05
ATC
insulin detemir; parenteral
5.7
12.5
24
45
R03AC02
ATC
salbutamol; inhalant
2.3
12.4
204
1348
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.8
12.4
41
120
R4190
NOMESCO Finland
Nutritional therapy
4.9
12.4
28
61
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
12.3
145
833
C01BD01
ATC
amiodarone; systemic
11.7
12.2
22
20
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
18.9
12.2
18
10
A10BA02
ATC
metformin; oral
2.6
12.1
87
400
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.5
12.0
30
71
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
6.2
11.9
21
36
P01BA02
ATC
hydroxychloroquine; oral
3.5
11.9
44
139
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.5
11.8
43
134
R02
ICPC
Shortness of breath/dyspnoea
2.9
11.8
65
260
A10AC01
ATC
insulin (human); parenteral
4.1
11.8
34
90
PH7FT
NOMESCO Finland
Inmplantation of filter to inferior vena cava with radiological guidance
+∞
11.5
11
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
11.5
11
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
12.4
11.5
20
17
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.1
11.4
53
192
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
17.8
11.3
17
10
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
13.4
11.3
19
15
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.5
11.1
40
124
T90
ICPC
Diabetes non-insulin dependent
2.6
11.1
73
320
N02AX02
ATC
tramadol; systemic, rectal
2.2
11.0
151
914
C08CA13
ATC
lercanidipine; oral
3.4
10.7
40
127
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
10.6
79
367
R03BB04
ATC
tiotropium bromide; inhalant
3.0
10.6
50
183
G47.3
ICD-10 Finland
Sleep apnoea
2.6
10.6
73
327
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
113.4
10.5
11
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
+∞
10.5
10
*
FB1AC
NOMESCO Finland
Angiography of arteria pulmonalis
+∞
10.5
10
*
4160A
ICD-9 Finland
Chronic pulmonary heart disease, Primary pulmonary hypertension
+∞
10.5
10
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.3
10.4
28
70
C01DA14
ATC
isosorbide mononitrate; oral
2.8
10.4
61
251
M34.1
ICD-10 Finland
CR(E)ST syndrome
33.7
10.4
13
*
C02EA02, ,
ATC
33.7
10.4
13
*
E66.8
ICD-10 Finland
Other obesity
5.5
10.2
20
38
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.6
10.1
66
287
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
8.0
10.1
22
29
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
41.4
10.0
12
*
C07AA07
ATC
sotalol; systemic
4.8
9.9
23
51
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
9.9
127
741
N02AA05
ATC
oxycodone; systemic
2.4
9.9
81
392
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.6
9.7
33
98
WX882
NOMESCO Finland
High dependency care
7.5
9.7
22
31
D68.8
ICD-10 Finland
Other specified coagulation defects
18.2
9.5
14
8
WX721
NOMESCO Finland
Oxygen concentrator therapy
31.0
9.5
12
*
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
5.1
9.4
20
41
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
4.3
9.4
25
62
PH3BC
NOMESCO Finland
Extensive flebography of internal organs with X-ray
+∞
9.4
9
*
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.4
9.3
78
380
J01MA14
ATC
moxifloxacin; systemic
3.0
9.3
44
161
C09AA05
ATC
ramipril; oral
2.4
9.3
78
381
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.0
9.3
27
72
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.9
9.2
48
185
R99
ICPC
Respiratory disease other
11.9
9.2
16
14
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.3
9.1
36
118
N18.8
ICD-10 Finland
Other chronic renal failure
16.2
9.1
14
9
L04AD01
ATC
ciclosporin; systemic
16.2
9.1
14
9
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.9
9.1
45
169
A10AE04
ATC
insulin glargine; parenteral
3.7
9.0
29
83
C07AG02
ATC
carvedilol; oral
8.3
9.0
19
24
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
9.0
109
619
TLC00
NOMESCO Finland
Insertion of intrauterine device
4.2
9.0
24
60
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
5.1
8.9
19
39
I50
ICD-10 Finland
Heart failure
4.9
8.9
20
43
J01FF01
ATC
clindamycin; systemic
2.2
8.9
92
490
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
8.0
8.8
19
25
ZXE00
NOMESCO Finland
One hour or less
2.0
8.7
138
862
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.6
8.7
58
254
WX725
NOMESCO Finland
Noninvasive ventilation
4.0
8.7
25
66
XF402
NOMESCO Finland
ECG with work load test
2.9
8.6
42
156
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
4.0
8.5
25
67
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
92.3
8.5
9
*
A10BH01
ATC
sitagliptin; oral
3.5
8.4
30
92
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.5
8.4
60
271
C09CA01
ATC
losartan; oral
2.3
8.4
71
347
FL1AC
NOMESCO Finland
Left cardioangiography
9.8
8.4
16
17
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
8.4
8
*
H11.3
ICD-10 Finland
Conjunctival haemorrhage
3.9
8.3
25
68
AA1AD
NOMESCO Finland
CT of head and brain
2.1
8.3
103
588
D64.9
ICD-10 Finland
Anaemia, unspecified
2.8
8.2
45
178
K29
ICPC
Cardiovascular sympt/complt other
4.7
8.2
19
42
RK110, ,
NOMESCO Finland
17.7
8.1
12
7
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.0
8.1
23
60
C09DA06
ATC
candesartan and diuretics; oral
4.5
8.1
20
47
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
6.4
8.0
20
33
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
8.1
8.0
17
22
A07AA09
ATC
vancomycin; oral
13.5
7.9
13
10
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
7.9
142
921
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.4
7.8
20
48
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.4
7.8
20
48
M10.0
ICD-10 Finland
Idiopathic gout
6.6
7.8
19
30
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.2
7.8
20
34
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.8
7.8
42
165
XW5WT
NOMESCO Finland
Other blood specimen with radiologicl guidance
46.1
7.7
9
*
C09DA01
ATC
losartan and diuretics; oral
3.7
7.7
25
72
WW200
NOMESCO Finland
Immunization
7.0
7.7
18
27
XX1XW
NOMESCO Finland
Extensive written report from radiologist
8.3
7.7
16
20
I26
ICD-10 Finland
Pulmonary embolism
12.2
7.6
13
11
C07AB03
ATC
atenolol; systemic
4.4
7.6
19
45
SPAT1255
SPAT
Intravenous administration of medicine
3.5
7.6
27
83
XF640, ,
NOMESCO Finland
6.7
7.5
18
28
XX4BW, ,
NOMESCO Finland
81.8
7.4
8
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
81.8
7.4
8
*
I28.9
ICD-10 Finland
Disease of pulmonary vessels, unspecified
81.8
7.4
8
*
RK320, ,
NOMESCO Finland
13.8
7.4
12
9
C10AA01
ATC
simvastatin; oral
1.9
7.4
127
807
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
7.4
36
134
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.7
7.3
41
164
GD1CN
NOMESCO Finland
Lung circulation isotope imaging
+∞
7.3
7
*
I87.0
ICD-10 Finland
Postthrombotic syndrome
+∞
7.3
7
*
A41.9
ICD-10 Finland
Sepsis, unspecified
4.5
7.3
18
42
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.5
7.3
18
42
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
7.3
44
183
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
7.3
96
556
C08CA10
ATC
nilvadipine; oral
20.5
7.2
10
5
C09CA03
ATC
valsartan; oral
3.7
7.1
23
66
I42.0
ICD-10 Finland
Dilated cardiomyopathy
7.2
7.1
16
23
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
7.2
7.1
16
23
XFE00
NOMESCO Finland
Epicardial ultrasonography
7.2
7.1
16
23
B01AF02
ATC
apixaban; oral
2.4
7.1
51
231
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.5
7.1
47
205
N19
ICD-10 Finland
Unspecified kidney failure
6.3
6.9
17
28
TK800
NOMESCO Finland
Hemodialysis
11.3
6.8
12
11
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
3.7
6.8
22
63
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
6.8
84
474
Q25.0
ICD-10 Finland
Patent ductus arteriosus
40.9
6.8
8
*
L04AA01
ATC
[U] ciclosporin
17.1
6.8
10
6
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
6.8
66
340
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
23.1
6.7
9
*
61
HP
Catheterization and pressure measurement of the left side of the heart
8.1
6.7
14
18
I20.09
ICD-10 Finland
Unstable angina
4.0
6.6
19
50
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
9.0
6.6
13
15
ZY010
NOMESCO Finland
Hospital outpatient
3.8
6.6
20
55
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
71.2
6.4
7
*
A07AA02
ATC
nystatin; oral
3.1
6.4
27
92
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
6.4
48
221
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.7
6.4
20
56
M10
ICD-10 Finland
Gout
5.7
6.4
17
31
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
5.7
6.4
17
31
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.3
66
349
N05CF01
ATC
zopiclone; oral
1.8
6.3
117
755
Q21.10
ICD-10 Finland
Persistent ostium secundum
18.4
6.3
9
5
I83.2
ICD-10 Finland
Varicose veins of lower extremities with both ulcer and inflammation
18.4
6.3
9
5
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
+∞
6.3
6
*
FXE00
NOMESCO Finland
Use of ECLA
+∞
6.3
6
*
3A064, ,
NOMESCO Finland
27.2
6.3
8
*
7AX01, ,
NOMESCO Finland
27.2
6.3
8
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
3.4
6.3
22
67
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.2
6.2
25
83
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
7.9
6.2
13
17
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
6.1
78
443
UJF32
NOMESCO Finland
Coloscopy
1.9
6.1
89
530
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
10.3
6.1
11
11
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.5
6.1
38
161
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.8
6.0
18
49
C09CA07
ATC
telmisartan; oral
3.8
6.0
18
49

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Pulmonary heart disease, unspecified
I27.9 (45548015)
Primary pulmonary hypertension
I27.0 (45552787)
Other specified pulmonary heart diseases
I27.8 (45557541)
Chronic hypertension
205 (2001600203)
macitentan; oral
C02KX04 (43534769)
Other secondary pulmonary hypertension
I27.2 (45581768)
riociguat; oral
C02KX05 (45893474)
Catheterisation of right atrium or ventricle
TFC00 (2001303396)
Pulmonary embolism
K93 (2002000620)
bosentan; oral
C02KX01 (21600448)
Measurement of pulmonary artery pressure
XF614 (2001303384)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Pulmonary embolism with mention of acute cor pulmonale
I26.0 (45567169)
Extensive CT examination of arteria pulmonalis
FB1BD (2001302407)
Thorax X-ray examination outside radiological department
GD1UA (2001303652)
Nitrogen oxide therapy
WX740 (2001310835)
More than three and less than five hours
ZXE20 (2001311408)
SMOKING - SMOKE2: no - SMOKE3: former - SMOKE5: Unspecified
SMOKING-2-2-0 (2002330110)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: Unspecified
SMOKING-2-3-0 (2002330113)
ambrisentan; oral
C02KX02 (21600449)
iloprost; inhalant, parenteral
B01AC11 (21600996)
Natriuretic peptide B [Mass/volume] in Serum or Plasma
30934-4 (3011960)
Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
3255-7 (3016407)
Cardiac output
82799009 (4221102)
selexipag; oral
B01AC27 (1588656)
Coronary angiography
AN1 (2000200163)
Standard cardiac ultrasound examination
FM1AE (2001303278)
Cardiac ultrasound examination through oesophagus
FM1BE (2001303285)
Doppler ultrasound examination of heart
FM1DE (2001303299)
Extensive structural and functional ultrasound examination of heart
FM1EE (2001303307)
ECG with 12 standard connections
XF400 (2001303368)
X-ray examination of the lungs in one projection
GD1PA (2001303645)
Ultrasound examination of lower leg veins
PH2AE (2001309451)
Physiotherapy
R4110 (2001310233)
Respiratory and circulatory monitoring
WX700 (2001310817)
Intensive care
WX872 (2001310844)
Scheduled procedure
ZXD10 (2001311387)
More than one and less than three hours
ZXE10 (2001311401)
Medical doctor
Z2221 (2001311556)
Physiotherapist
Z3226 (2001311560)
Selexipag
383 (2001600344)
treprostinil; parenteral
B01AC21 (21601003)
furosemide; oral, parenteral
C03CA01 (21601518)
Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
27811-9 (3000515)
Forced vital capacity [Volume] Respiratory system --post bronchodilation
19875-4 (3001668)
Base excess in Arterial blood by calculation
1925-7 (3003396)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
EKG study
11524-6 (3013512)
Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1920-8 (3013721)
Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
19072-8 (3016431)
Oxygen saturation in Arterial blood
2708-6 (3016502)
aPTT in Platelet poor plasma by Coagulation assay
14979-9 (3018677)
Gas panel - Arterial blood
24336-0 (3019060)
Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
3209-4 (3019250)
pH of Arterial blood
2744-1 (3019977)
Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
3216-9 (3020427)
Troponin I.cardiac [Mass/volume] in Serum or Plasma
10839-9 (3021337)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
FEV1 --post bronchodilation
20155-8 (3023550)
Oxygen [Partial pressure] in Arterial blood
2703-7 (3027801)
Carbon dioxide [Partial pressure] in Arterial blood
2019-8 (3027946)
Prothrombin time (PT) actual/Normal
5894-1 (3033658)
Thrombin time
3243-3 (3036489)
Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
48065-7 (3051714)
Pulmonary Disease
29 (38004472)
FEV1/FVC --post bronchodilation
69970-2 (42868459)
FVC percent change Respiratory system
69982-7 (42868471)
FEV1 percent change
69983-5 (42868472)
Pulmonary embolism without mention of acute cor pulmonale
I26.9 (45552785)
Dyspnoea
R06.0 (45558449)
Erysipelas
A46 (45561706)
Type 2 diabetes mellitus, without complications
E11.9 (45561952)
Sleep apnoea
G47.3 (45562094)
Asthma, unspecified
J45.9 (45562456)
Heart failure, unspecified
I50.9 (45576879)
Atherosclerotic heart disease
I25.1 (45596196)
Atrial fibrillation and flutter
I48 (45596206)
Pneumonia, unspecified
J18.9 (45601123)
Lung transplant status
Z94.2 (45609997)
Inpatient Visit
IP (9201)
spironolactone; oral
C03DA01 (21601534)
Cardiology
6 (38004451)
sildenafil; oral
G04BE03 (21602648)
Thorax X-ray examination
GD1AA (2001303617)
Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
33762-6 (3029187)
warfarin; oral, parenteral
B01AA03 (21600965)
Essential (primary) hypertension
I10 (45591453)
digoxin; oral, parenteral
C01AA05 (21600234)
Outpatient Visit
OP (9202)
Internal Medicine
11 (38004456)
Office Visit
OMOP4822458 (581477)
Troponin T.cardiac [Mass/volume] in Serum or Plasma
6598-7 (3019800)
Outpatient Hospital
22 (8756)
Rheumatology
66 (38004491)
Urate [Moles/volume] in Serum or Plasma
14933-6 (3026493)
INR in Blood by Coagulation assay
34714-6 (3032080)
Inpatient Hospital
21 (8717)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
CBC W Ordered Manual Differential panel - Blood
57782-5 (40760892)
Ferritin [Mass/volume] in Serum or Plasma
2276-4 (3001122)
potassium chloride; oral
A12BA01 (21600877)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
enoxaparin; parenteral
B01AB05 (21600976)
diltiazem; oral
C08DB01 (21601771)
Hematology
82 (38004501)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
Chronic kidney disease, unspecified
N18.9 (45553438)
amlodipine; oral
C08CA01 (21601747)
Differential panel, method unspecified - Blood
69738-3 (42870588)
Bacteria identified in Blood by Culture
600-7 (3023368)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
30248-9 (3015399)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Basophils [#/volume] in Blood
26444-0 (3006315)
Procedure duration 50 to 59 minutes
ZXE06 (2001311400)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Epithelial cells [#/volume] in Urine
30383-4 (3000850)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
CBC panel - Blood by Automated count
58410-2 (40761511)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Other specified chronic obstructive pulmonary disease
J44.8 (45586673)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
Thoracic and Cardiac Surgery
OMOP4822009 (45756830)
Emergency Room Visit
ER (9203)
Casts [#/volume] in Urine by Automated count
51483-6 (3030467)
FEV1/FVC
19926-5 (3011505)
Forced vital capacity [Volume] Respiratory system
19870-5 (3020158)
FEV1
20150-9 (3024653)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
allopurinol; oral, parenteral
M04AA01 (21604131)
Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M
62238-1 (40764999)
Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method
4537-7 (3013707)
Iron [Moles/volume] in Serum or Plasma
14798-3 (3022948)
Bacteria [Presence] in Urine
87829-8 (36304419)
Iron/Transferrin [Ratio] in Serum or Plasma
60517-0 (40763571)
tiotropium bromide; inhalant
R03BB04 (21603296)
Angiography of heart and/or coronary arteries
FN1AC (2001302996)
Supplier / Service Provider
OMOP5117446 (33004)
prednisolone
A07EA01 (21600653)
prednisolone; oral, parenteral
H02AB06 (21602734)
Transferrin [Mass/volume] in Serum or Plasma
3034-6 (3004789)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
MCH [Entitic mass]
28539-5 (3035941)
Platelets [#/volume] in Blood
26515-7 (3007461)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
Erythrocytes [#/volume] in Urine
30391-7 (3002582)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
Urinalysis microscopic panel [#/volume] - Urine by Automated count
50554-5 (3029287)
Normoblasts [#/volume] in Blood
715-3 (3021589)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
Pharmacy visit
OMOP4822462 (581458)
12 lead EKG panel
34534-8 (3044889)
Physical Medicine And Rehabilitation
25 (38004468)
pH of Serum or Plasma
2753-2 (3018418)
High resolution CT examination of lungs
GD1DD (2001303632)
nifedipine; oral, parenteral
C08CA05 (21601751)
Congestive heart failure
I50.0 (45567179)
Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
34487-9 (3044938)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
Urea [Moles/volume] in Serum or Plasma
22664-7 (3020779)
bisoprolol; oral
C07AB07 (21601689)
Chronic respiratory failure
J96.1 (45557632)
metoprolol; oral, parenteral
C07AB02 (21601684)
Leukocytes [#/volume] in Urine
30405-5 (3018095)
Abdominal ultrasound examination
JN3AE (2001305555)
Glucose [Moles/volume] in Serum or Plasma
14749-6 (3013826)
Nuclear Ab [Titer] in Serum
29953-7 (3037522)
One hour or less
ZXE00 (2001311394)
Complement C3 [Mass/volume] in Serum or Plasma
4485-9 (3000620)
Complement C4 [Mass/volume] in Serum or Plasma
4498-2 (3017766)
Laboratory Visit
OMOP4822461 (32036)
Psychiatry
26 (38004469)
Intravenous
ZX120 (2001311495)
amoxicillin and beta-lactamase inhibitor; oral, parenteral
J01CR02 (21602863)
metformin; oral
A10BA02 (21600747)
General Practice
1 (38004446)
Clinical & Laboratory Dermatological Immunology Physician
207NI0002X (38003841)
Short blood count panel - Blood
55429-5 (40758558)
Emergency Medicine
93 (38004510)
isosorbide mononitrate; oral
C01DA14 (21600324)
Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
14804-9 (3022250)
enalapril; oral, parenteral
C09AA02 (21601786)
salbutamol; inhalant
R03AC02 (21603256)
Atrial fibrillation/flutter
K78 (2002000605)
Magnesium [Moles/volume] in Serum or Plasma
2601-3 (3012095)
Cathetrisation of vein
TPH04 (2001309597)
cefalexin; oral
J01DB01 (21602870)
pantoprazole; oral, parenteral
A02BC02 (21600097)
Reticulocytes/Erythrocytes in Blood
4679-7 (3027945)
Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
40982-1 (3038288)
Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
40987-0 (3043924)
Osmolality of Urine
2695-5 (3026782)
Bacteria [#/volume] in Urine by Automated count
51480-2 (3031040)
Case Management Agency
251B00000X (38004193)
Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
1742-6 (3006923)
Esophagoscopy, gastroscopy and duodenoscopy
UJD10 (2001304788)
Thyrotropin [Units/volume] in Serum or Plasma
3016-3 (3009201)
Diabetes non-insulin dependent
T90 (2002001131)
Endocrinology
46 (38004485)
candesartan; oral
C09CA06 (21601829)
Blood type and Crossmatch panel - Blood
34531-4 (3044640)
tadalafil; oral
G04BE08 (21602653)
Telehealth
OMOP5556618 (722455)
paracetamol; oral, parenteral, rectal
N02BE01 (21604344)
Procedure duration 60 to 89 minutes
ZXE11 (2001311402)
isosorbide dinitrate; local oral, oral, sublingual, transdermal
C01DA08 (21600321)
Gastroenterology
10 (38004455)
tramadol; oral, parenteral, rectal
N02AX02 (21604298)
Clinical Cytogenetics and Genomics
OMOP4822000 (32411)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
121
158
11.46
93.68
9.7
2.8
310.67
231.27
ng/l
0.73
116
141
90
93
12.89
81.62
5.7
2.3
20.89
22.13
s
0.53
84
83
59
29
24.51
79.40
1.5
1.2
2.31
1.60
u/ml
—
29
10
232
753
7.86
74.89
13.8
3.0
1453.24
1141.30
ng/l
1.07
225
630
53
28
22.32
68.93
1.3
1.2
—
—
—
0
0
190
547
6.76
68.32
9.5
2.4
385.96
322.93
umol/l
9.23
184
477
126
256
7.31
64.60
19.0
7.3
4.83
5.19
kpa
2.68
121
244
125
252
7.34
64.58
18.9
7.4
7.43
7.42
ph
0.53
82
146
126
257
7.28
64.33
18.9
7.3
9.88
11.84
kpa
6.34
121
246
123
251
7.18
62.61
19.2
7.4
1.16
0.88
mmol/l
0.26
100
211
87
141
8.00
54.46
5.1
4.7
—
—
—
0
0
203
803
4.91
45.66
11.8
3.0
27.67
33.86
u/l
1.64
198
764
45
38
13.54
45.49
7.9
3.9
6.36
8.68
kpa
5.15
45
38
37
23
17.97
44.16
2.5
2.1
—
—
—
0
0
245
1191
5.00
40.31
52.5
10.7
1.68
1.21
inr
20.77
225
974
180
720
4.26
38.15
6.1
2.3
3.31
3.03
mg/l
0.57
172
601
141
480
4.36
37.20
8.4
3.2
854.09
331.36
ng/l
0.36
129
363
118
358
4.56
36.16
1.7
1.4
670.27
583.33
titre
0.24
37
72
90
227
5.06
34.61
6.9
3.0
7.38
7.38
ph
0.10
65
143
147
547
4.02
33.68
8.2
1.7
1.56
1.57
mg/l
0.01
116
423
32
27
13.01
32.10
1.3
1.2
—
—
—
0
0
32
28
12.54
31.37
1.3
1.2
—
—
—
0
0
116
385
4.09
30.90
12.8
3.2
0.80
0.83
mmol/l
1.43
111
362
86
229
4.71
30.68
7.0
3.0
1.51
2.15
mmol/l
0.68
73
188
163
694
3.64
29.80
7.1
3.8
—
—
—
0
0
67
150
5.34
29.31
29.3
9.0
24.51
24.99
mmol/l
0.42
67
150
38
48
8.81
28.72
1.1
1.1
—
—
—
0
0
45
72
7.07
27.75
1.2
1.2
—
378.00
—
0
5
36
45
8.85
27.40
8.8
4.6
61.77
59.36
%
0.22
36
45
55
111
5.74
26.89
2.6
1.6
4.07
12.67
iu/ml
0.88
11
21
196
986
3.40
26.58
8.0
3.3
117.90
90.91
ng/l
0.09
171
688
76
207
4.46
26.06
31.1
6.2
—
—
—
0
0
186
919
3.32
25.76
14.4
6.2
—
—
—
0
0
29
30
10.49
25.35
4.4
1.6
—
—
—
0
0
29
30
10.49
25.35
4.4
1.6
—
—
—
0
0
29
30
10.49
25.35
4.4
1.6
—
—
—
0
0
29
30
10.49
25.35
4.4
1.6
—
—
—
0
0
218
1204
3.35
24.63
11.4
4.0
34.83
35.33
g/l
0.67
210
1118
31
38
8.89
23.89
8.8
4.0
2.21
1.83
mmol/l
0.30
24
24
31
38
8.89
23.89
8.8
4.0
5.05
4.88
kpa
0.61
31
38
224
1273
3.32
23.79
14.8
6.3
2.44
2.84
%
2.44
214
1170
225
1288
3.30
23.48
15.0
6.4
24.72
28.61
%
6.17
215
1207
223
1271
3.28
23.42
14.8
6.4
0.71
0.70
%
0.07
212
1161
93
315
3.71
23.36
27.4
6.6
104.48
104.15
mmol/l
0.22
93
315
223
1273
3.28
23.32
15.0
6.4
9.25
8.88
%
1.03
213
1172
33
48
7.52
22.05
1.1
1.0
—
—
—
0
0
95
341
3.50
21.68
3.8
1.7
—
—
—
0
0
67
191
4.14
21.39
2.0
2.8
—
—
—
0
0
84
289
3.55
20.36
3.3
2.7
2.22
1.67
%
3.02
79
260
226
1373
3.01
19.80
14.7
6.2
0.61
0.57
e9/l
1.81
208
1177
215
1276
2.93
19.60
14.9
6.3
59.88
56.51
%
3.82
210
1197
226
1380
2.98
19.48
14.7
6.2
0.04
0.04
e9/l
0.52
208
1183
231
1433
3.00
19.23
15.4
6.4
0.17
0.19
e9/l
1.13
215
1244
228
1410
2.96
18.98
15.3
6.2
1.62
1.98
e9/l
3.56
212
1242
46
108
4.78
18.73
2.2
2.0
1.11
1.48
g/l
1.72
37
95
114
507
2.90
17.62
4.5
2.5
500.31
533.52
mosm/kgh2o
1.07
103
448
77
277
3.32
17.18
1.6
1.4
—
—
—
0
0
236
1536
2.84
16.94
18.2
9.9
4.34
3.95
e9/l
1.61
219
1347
35
73
5.24
16.30
8.7
2.8
7.42
7.41
ph
0.92
35
73
148
778
2.62
16.25
4.9
2.1
176.35
261.39
u/l
0.39
143
745
205
1262
2.62
16.14
7.1
2.7
109.26
115.99
ug/l
0.17
199
1163
64
219
3.38
15.37
2.8
2.7
86.36
62.44
e9/l
3.06
47
164
19
6
33.44
14.97
1.3
1.3
30.84
27.50
s
—
19
6
51
153
3.76
14.94
39.1
8.5
92.20
94.46
%
0.84
51
153
36
83
4.74
14.91
1.1
1.2
—
—
—
0
0
49
144
3.82
14.78
40.4
8.6
0.64
0.66
%
0.20
49
144
50
150
3.75
14.63
39.7
8.4
1.25
1.27
%
0.06
50
150
119
587
2.60
14.61
4.4
2.3
3.63
7.31
e6/l
1.82
108
534
213
1376
2.52
14.52
20.9
5.9
1.18
1.22
mmol/l
10.22
194
1178
198
1247
2.45
14.13
20.3
5.4
1.18
1.22
mmol/l
11.17
190
1125
29
58
5.38
14.11
3.9
3.1
0.80
0.80
nmol/l
0.03
24
46
146
806
2.44
13.95
7.4
3.5
7.41
7.40
ph
3.26
122
578
51
160
3.58
13.95
1.2
1.3
323.44
148.31
u/ml
—
10
64
22
36
6.47
13.10
5.5
2.6
—
—
—
0
0
222
1528
2.36
12.16
17.7
4.1
6.70
6.34
mmol/l
2.12
216
1442
17
9
19.82
11.71
2.7
9.0
17.62
13.17
%
—
17
9
93
449
2.49
11.58
1.7
1.9
—
—
—
0
0
82
373
2.59
11.57
1.6
1.7
—
—
—
0
0
62
246
2.87
11.40
9.1
4.3
0.76
0.72
%
0.06
27
72
134
764
2.26
11.37
5.9
2.8
0.54
0.44
e6/l
0.19
117
560
69
293
2.71
11.15
4.1
2.8
10.40
8.07
umol/l
0.70
63
258
60
237
2.87
11.11
9.6
4.7
0.52
0.29
%
0.17
23
52
147
880
2.20
10.98
5.9
2.8
50.74
147.33
e6/l
0.60
129
659
59
234
2.85
10.83
8.8
4.2
0.65
0.46
%
0.48
26
65
184
1208
2.17
10.81
25.4
10.3
0.00
0.00
e9/l
0.20
160
998
21
41
5.40
10.45
3.8
3.7
4.32
3.99
e9/l
0.34
21
41
47
170
3.05
10.15
8.4
4.0
7.42
7.42
ph
0.42
41
140
17
14
12.72
9.96
4.7
3.2
34.75
115.23
ug/l
1.25
17
14
57
235
2.72
9.68
9.0
4.4
0.05
0.08
%
0.26
22
60
42
148
3.10
9.47
4.4
3.1
4.08
4.54
pmol/l
1.97
36
134
13
6
22.46
9.42
2.1
2.0
—
—
—
0
0
136
831
2.08
9.26
11.7
6.2
—
—
—
0
0
64
296
2.44
8.55
3.3
1.6
—
—
—
0
0
53
224
2.62
8.54
2.6
2.3
61.33
31.52
u/l
0.48
46
186
22
54
4.29
8.40
1.3
1.3
132.36
163.56
au/ml
0.68
11
16
37
130
3.08
8.37
8.5
4.1
—
—
—
0
0
20
31
6.79
8.32
4.1
3.6
—
—
—
0
0
110
646
2.05
8.15
3.6
2.8
53.28
28.83
mg/l
0.56
85
367
35
123
3.06
7.91
6.2
2.8
0.59
0.62
%
0.19
35
123
35
124
3.04
7.80
6.2
2.8
1.30
1.11
%
0.67
35
124
89
490
2.11
7.80
1.3
1.3
38.82
38.01
iu/ml
0.03
24
139
27
82
3.49
7.70
2.0
1.3
27.63
1.46
u/ml
—
6
8
140
909
1.93
7.70
3.5
3.0
—
—
—
0
0
109
653
1.99
7.56
4.1
3.3
9.60
5.25
mg/mmol
0.43
85
351
102
598
2.02
7.51
10.3
4.9
—
—
—
0
0
17
25
7.11
7.39
1.3
1.5
—
—
—
0
0
151
1017
1.89
7.34
7.6
3.4
64.75
142.94
e6/l
0.55
128
700
11
7
16.18
7.27
4.4
1.0
—
—
—
0
0
81
444
2.09
7.12
5.0
2.6
3.21
2.44
e6/l
0.32
51
217
129
833
1.90
7.08
4.0
2.4
—
—
—
0
0
54
252
2.36
7.02
3.2
1.5
—
—
—
0
0
47
206
2.49
7.00
3.3
2.2
106.26
64.10
ng/l
2.85
42
177
112
704
1.89
6.59
3.7
2.8
6.18
7.23
mmol/l
2.37
106
576
15
23
6.77
6.41
2.2
2.0
86.66
89.13
%
0.50
15
23
60
313
2.12
5.94
4.5
1.4
—
—
—
0
0
39
174
2.41
5.58
1.7
1.4
—
—
—
0
0
21
68
3.23
5.44
3.4
2.6
4.00
2.21
index
0.50
13
38
87
534
1.85
5.38
1.8
1.6
415.80
41163241.91
pmol/l
0.75
73
430
21
69
3.18
5.32
4.1
2.8
59.81
57.70
%
0.41
21
69
8
6
13.62
5.10
1.4
1.2
—
—
—
0
0
94
600
1.79
5.09
2.3
1.4
2.09
2.24
g/l
0.42
71
342
15
32
4.86
5.05
1.1
1.1
—
—
—
0
0
227
1854
1.70
4.83
7.7
4.1
—
3.08
—
0
7
13
25
5.37
4.82
2.1
2.0
52.50
37.71
ug/min
—
6
12
79
486
1.82
4.80
1.9
1.7
1073.58
1227.11
nmol/l
0.84
67
343
22
80
2.87
4.71
5.5
5.6
1.70
1.17
mmol/l
0.88
22
80
12
23
5.37
4.50
2.1
1.7
10.62
10.26
mmol/l
0.16
12
23
18
60
3.11
4.47
1.1
2.2
—
—
—
0
0
41
206
2.13
4.45
4.9
3.6
1.22
1.23
mmol/l
0.40
36
175
23
89
2.70
4.41
1.3
1.5
—
—
—
0
0
158
1196
1.61
4.38
4.7
2.8
—
—
estimate
—
0
0
10
16
6.41
4.32
2.2
1.3
1.00
1.06
index
—
10
16
13
30
4.47
4.17
2.6
2.2
30.77
32.33
pg
0.61
13
30
10
17
6.03
4.16
2.6
9.9
11.94
11.04
%
—
10
17
11
24
4.70
3.77
1.1
1.3
—
—
—
0
0
6
5
12.18
3.77
5.5
2.4
47.92
60.80
%
—
6
5
7
9
7.91
3.57
1.1
8.8
10.19
6.81
mmol/l
—
7
9
13
36
3.71
3.53
1.8
1.3
—
—
—
0
0
20
81
2.56
3.53
3.6
4.3
68.81
47.69
mg/l
0.17
14
71
9
17
5.41
3.53
1.1
1.1
—
—
—
0
0
19
75
2.63
3.53
3.7
4.0
1.50
2.71
ratio
0.78
11
42
12
31
3.98
3.52
2.0
1.4
—
—
—
0
0
20
82
2.53
3.45
3.6
4.3
37.67
106.16
mg/l
0.48
15
72
7
10
7.12
3.38
1.3
1.5
—
—
—
0
0
5
188
0.25
3.37
2.0
2.3
8.21
13.11
nmol/l
—
5
169
233
2605
0.65
3.13
5.6
5.2
2.37
2.78
mmol/l
11.79
225
2360
37
206
1.90
3.06
8.3
3.4
—
—
—
0
0
14
51
2.82
3.02
4.4
2.4
1.55
1.49
mmol/l
0.11
14
51
225
2528
0.66
3.01
5.0
4.6
1.38
1.55
mmol/l
6.70
214
2281
48
294
1.74
2.92
1.6
1.4
—
—
—
0
0
7
13
5.47
2.88
2.4
3.5
908.57
823.23
u/ml
—
7
13
66
937
0.63
2.83
2.5
2.8
—
—
—
0
0
12
39
3.15
2.80
6.2
3.8
—
—
—
0
0
153
1232
1.45
2.79
3.9
2.4
75.45
78.55
nmol/l
0.68
143
1077
5
6
8.43
2.76
6.4
1.3
—
—
—
0
0
12
40
3.07
2.72
2.3
1.3
30.64
5.31
pmol/l
0.61
12
40
228
2540
0.68
2.71
5.2
4.6
4.21
4.75
mmol/l
14.09
220
2312
19
86
2.28
2.69
1.3
1.2
—
—
—
0
0
52
339
1.63
2.53
1.3
1.2
—
—
—
0
0
201
1723
1.42
2.49
5.4
3.0
65.06
43.26
u/l
4.17
194
1587
16
70
2.35
2.45
7.1
4.7
3.94
3.90
mmol/l
0.16
16
70
6
13
4.68
2.28
5.7
3.5
327.33
55.62
nmol/l
—
6
13
15
66
2.33
2.28
3.7
1.8
126.33
124.79
g/l
—
9
48
25
136
1.91
2.25
1.3
1.3
—
—
—
0
0
8
25
3.25
2.11
1.8
1.6
20.15
36.54
ng/l
—
8
25
96
745
1.41
2.03
5.6
3.2
0.00
0.13
estimate
0.63
50
231
8
26
3.13
2.02
1.4
1.1
—
—
—
0
0
107
847
1.39
2.02
1.9
1.6
18.64
20.86
nmol/l
0.76
101
677
6
16
3.80
1.94
1.3
2.5
47.32
36.84
%
—
6
16
13
58
2.29
1.93
2.1
2.0
—
—
—
0
0
233
2541
0.72
1.91
5.2
4.7
6.02
5.73
mmol/l
2.72
220
2271
125
1024
1.35
1.89
6.0
3.2
2.32
2.36
mmol/l
3.13
120
903
7
23
3.09
1.81
5.7
3.1
34.57
2.81
nmol/l
—
7
23
167
1439
1.32
1.76
7.1
3.7
0.00
1.07
estimate
0.50
61
281
84
1055
0.73
1.74
2.0
1.8
1.36
1.25
mmol/l
0.67
73
877
17
89
1.96
1.73
2.2
2.4
290.25
157.91
mg/l
—
8
32
7
25
2.84
1.66
4.0
1.6
4.11
4.00
mmol/l
—
7
25
5
14
3.61
1.62
1.4
1.3
2.16
1.76
mmol/l
—
5
14
163
1412
1.30
1.60
6.8
3.6
0.00
0.00
estimate
0.50
62
277
131
1112
1.29
1.47
4.9
3.3
6.23
6.30
ph
0.32
73
593
9
38
2.41
1.46
2.1
1.8
—
—
—
0
0
5
16
3.16
1.44
1.0
1.0
—
—
—
0
0
21
127
1.70
1.40
2.2
2.4
—
—
—
0
0
7
29
2.44
1.40
1.6
1.1
—
—
—
0
0
9
41
2.23
1.38
5.7
2.4
10.22
6.71
mmol/l
—
9
41
222
2400
0.78
1.36
4.5
3.9
1.27
1.19
mmol/l
1.51
213
2139
5
17
2.97
1.36
1.6
1.3
—
—
—
0
0
5
17
2.97
1.36
1.6
1.9
1244.20
279.35
mg
—
5
17
6
24
2.53
1.31
1.0
1.6
—
—
—
0
0
97
805
1.29
1.28
7.1
3.6
0.00
0.00
estimate
0.50
56
266
83
675
1.31
1.27
1.4
1.3
0.60
1.45
u/ml
1.88
27
165
162
1433
1.25
1.25
7.0
3.7
0.00
5.72
estimate
0.50
63
284
6
25
2.42
1.25
4.5
1.6
104.17
107.00
mmol/l
—
6
25
6
25
2.42
1.25
4.5
1.6
1.17
1.19
mmol/l
—
6
25
30
208
1.49
1.18
2.8
2.0
0.25
0.90
e6/l
1.72
30
197
5
20
2.52
1.15
1.0
1.0
—
—
—
0
0
7
30
2.36
1.13
1.0
1.1
—
—
—
0
0
5
21
2.40
1.09
1.4
2.3
—
—
—
0
0
7
32
2.21
1.08
1.1
1.2
98.43
123.12
pmol/l
—
7
32
11
59
1.89
1.08
1.1
1.2
—
—
—
0
0
85
716
1.25
0.98
1.5
1.4
—
—
—
0
0
8
144
0.54
0.95
2.0
2.0
—
—
—
0
0
6
120
0.49
0.95
1.3
1.8
—
—
—
0
0
137
1218
1.21
0.95
2.3
2.0
82.62
99.65
pmol/l
4.72
83
625
57
459
1.29
0.95
1.3
1.3
38.90
10.30
u/ml
0.67
15
164
29
211
1.41
0.92
5.0
2.9
6.13
6.07
ph
0.14
24
138
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
119
1066
1.18
0.73
6.6
3.7
0.02
0.07
estimate
0.79
52
243
31
239
1.33
0.72
1.2
1.2
—
—
—
0
0
16
109
1.49
0.72
1.3
1.2
—
—
—
0
0
7
41
1.72
0.70
1.0
1.1
—
—
—
0
0
7
41
1.72
0.70
1.0
1.1
—
—
—
0
0
7
43
1.64
0.67
1.3
1.2
—
—
—
0
0
18
244
0.72
0.63
1.3
1.6
—
—
—
0
0
10
63
1.61
0.62
3.0
3.5
—
—
—
0
0
0
21
0.00
0.60
0.0
2.5
—
—
—
0
0
0
22
0.00
0.59
0.0
11.2
—
674.45
—
0
22
17
123
1.40
0.59
3.9
1.7
0.00
0.00
estimate
-0.00
11
35
0
23
0.00
0.58
0.0
15.8
—
1209.00
—
0
23
12
81
1.50
0.58
1.2
2.1
0.96
8587.27
u/l
—
5
26
34
406
0.82
0.48
2.5
3.0
0.66
0.82
ug/l
0.74
21
255
31
257
1.23
0.45
3.3
1.9
0.00
0.00
estimate
—
9
46
13
173
0.74
0.43
1.4
1.4
—
26.55
—
0
19
0
17
0.00
0.41
0.0
1.3
—
186.44
—
0
17
7
101
0.69
0.40
1.0
1.0
—
—
—
0
0
9
69
1.31
0.37
1.7
1.1
3.11
3.53
mmol/l
—
9
63
36
310
1.18
0.37
2.4
4.5
36.04
35.91
ug/l
0.00
25
256
5
37
1.36
0.37
1.0
1.2
—
—
—
0
0
270
2642
1.12
0.30
48.6
13.8
22.77
25.17
mg/l
0.65
259
2108
15
185
0.80
0.30
1.5
1.2
—
—
—
0
0
7
54
1.30
0.30
1.6
1.2
—
—
—
0
0
42
374
1.14
0.30
1.8
2.5
303.69
122.85
ug/g
0.50
36
274
10
76
1.33
0.28
2.2
2.8
—
—
—
0
0
8
65
1.24
0.27
1.9
1.1
45.63
3.40
e6/l
—
8
45
8
66
1.22
0.27
1.9
1.2
110.63
169.34
e6/l
—
8
47
65
601
1.10
0.26
4.2
2.8
2.47
2.46
mmol/l
0.17
57
532
26
227
1.16
0.24
1.8
1.4
—
—
—
0
0
9
77
1.17
0.24
2.0
1.2
504.89
427.72
mg/l
—
9
71
270
2745
0.91
0.23
39.1
12.0
—
—
—
0
0
8
102
0.78
0.21
1.0
1.1
—
—
—
0
0
214
2089
1.07
0.21
6.0
4.2
15.71
14.82
pmol/l
5.45
203
1884
67
628
1.08
0.20
6.1
4.1
1.02
1.02
kg/l
0.71
50
410
62
660
0.93
0.19
4.3
5.7
2.98
3.54
ug/l
0.21
52
580
10
82
1.23
0.17
2.4
1.6
—
—
—
0
0
5
70
0.71
0.17
1.0
4.6
18.60
31.43
u/ml
—
5
70
18
158
1.15
0.16
2.9
2.7
96.63
129.88
u/ml
0.26
18
153
10
83
1.21
0.15
2.4
1.6
—
—
—
0
0
10
83
1.21
0.15
2.4
1.6
—
—
—
0
0
7
87
0.80
0.14
1.7
1.3
—
—
—
0
0
10
84
1.20
0.14
15.7
9.9
—
—
—
0
0
10
85
1.18
0.12
2.4
1.6
—
—
—
0
0
26
240
1.09
0.11
1.3
1.9
—
—
—
0
0
16
144
1.12
0.10
1.2
1.2
—
142.00
titre
—
0
5
5
44
1.14
0.10
2.4
1.4
—
—
—
0
0
248
2466
1.02
0.04
8.8
5.2
2.12
1.95
mu/l
1.53
238
2228
35
343
1.02
0.01
1.3
1.3
—
—
—
0
0
107
1068
1.00
0.00
2.7
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
0.00
—
0
6
7
78
0.90
-0.00
3.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
57.67
—
0
6
0
5
0.00
-0.00
0.0
2.2
—
14.46
—
0
5
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
7.53
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
67.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
4.75
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.6
—
3.47
—
0
9
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
0.48
—
0
7
0
8
0.00
-0.00
0.0
6.1
—
3.46
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
3.42
—
0
5
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.02
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint I9_HYPTENSPUL and mortality.

Females

Parameter HR [95% CI] p-value
I9_HYPTENSPUL 4.18 [3.33, 5.24] < 0.001
Birth year 0.994 [0.99, 1.0] 0.19

During the follow-up period (1.1.1998 — 31.12.2019), 588 out of 1066 females with I9_HYPTENSPUL died.

Males

Parameter HR [95% CI] p-value
I9_HYPTENSPUL 4.585 [3.19, 6.59] < 0.001
Birth year 0.99 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 390 out of 643 males with I9_HYPTENSPUL died.

Mortality risk

Mortality risk for people of age

years, who have I9_HYPTENSPUL.

N-year risk Females Males
1 0.421% 0.888%
5 2.404% 5.63%
10 6.259% 13.925%
15 11.562% 25.475%
20 19.153% 39.831%

Relationships between endpoints

↥

Index endpoint: I9_HYPTENSPUL – Hypertension, Pulmonary Arterial

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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