restrictive cardiomyopathy: A type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. Causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
142 |
4. Check minimum number of eventsNone |
142 |
5. Include endpointsNone |
142 |
6. Filter based on genotype QC (FinnGen only) |
121 |
Control definitions (FinnGen only)
- Control exclude
- I9_CARDMYO
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I42
- Name in latin
- Cardiomyopathia restrictiva
Similar endpoints
↥List of similar endpoints to
Restrictive cardiomyopathy
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathies, Primary/intrinsic
- Cardiomyopathy (excluding other)
- Cardiomyopathy
- Other heart diseases
- Other heart diseases, wide
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 790 | 397 | 379 |
| Only index persons | 553 | 298 | 255 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 68.55 | 72.32 | 64.68 |
| Only index persons | 70.21 | 73.52 | 66.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 121 | 53 | 68 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 67.64 | 70.78 | 65.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 126
- Matched controls
- 1260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I42.5
ICD-10 Finland
Other restrictive cardiomyopathy
+∞
163.9
119
*
C03DA01
ATC
spironolactone; oral
23.0
74.2
84
101
I50.9
ICD-10 Finland
Heart failure, unspecified
21.1
65.6
95
160
I50.0
ICD-10 Finland
Congestive heart failure
14.1
50.1
64
86
201
Kela drug reimbursment
Chronic cardiac insufficiency
18.6
50.0
47
39
B01AA03
ATC
warfarin; systemic
11.9
44.6
83
176
C03CA01
ATC
furosemide; systemic
21.7
42.0
113
360
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
546.4
40.5
38
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
10.5
40.5
78
169
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
38.5
35
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
9.9
37.4
84
212
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
35.0
32
*
TFP20
NOMESCO Finland
Cardiodefibrillation
10.4
30.9
42
58
I48
ICD-10 Finland
Atrial fibrillation and flutter
7.9
30.3
80
228
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
11.2
29.9
37
45
AN1
HP
Coronary angiography
8.7
29.7
50
89
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
12.1
27.4
31
33
C01AA05
ATC
digoxin; systemic
8.5
26.7
43
72
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
10.8
26.6
33
40
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
12.0
24.1
27
28
207
Kela drug reimbursment
Chronic arrhythmias
6.1
22.5
58
154
M04AA01
ATC
allopurinol; systemic
6.4
22.4
52
125
I50.1
ICD-10 Finland
Left ventricular failure
10.1
21.4
27
33
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
+∞
20.4
19
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
52.8
18.9
22
5
K78
ICPC
Atrial fibrillation/flutter
6.7
18.5
35
68
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
25.6
18.2
25
12
C07AB07
ATC
bisoprolol; oral
7.0
18.0
105
526
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
7.5
17.7
29
48
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.9
16.5
52
158
Z94.1
ICD-10 Finland
Heart transplant status
181.6
15.9
16
*
XF404
NOMESCO Finland
Ambulatory ECG
6.0
15.8
33
70
WX892
NOMESCO Finland
Monitored bed care
7.0
15.7
27
47
M10.9
ICD-10 Finland
Gout, unspecified
6.8
15.6
28
51
Z2221
NOMESCO Finland
Medical doctor
4.5
15.5
62
225
XF400
NOMESCO Finland
ECG with 12 standard connections
4.6
15.0
49
152
TFJ02
NOMESCO Finland
Muscle biopsy of heart
91.0
14.9
16
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.1
14.9
97
498
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
14.9
14
*
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
26.1
14.8
20
9
127
Kela drug reimbursment
Transplant complication
29.7
13.8
18
7
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
156.1
13.7
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
13.1
39
111
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
14.6
12.7
21
17
C01BD01
ATC
amiodarone; systemic
17.0
12.2
19
13
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.0
11.8
23
45
L04AD02
ATC
tacrolimus; systemic
39.0
11.5
14
*
L04AA06
ATC
mycophenolic acid; systemic
28.1
11.4
15
6
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.9
11.3
46
163
I50
ICD-10 Finland
Heart failure
11.2
11.3
21
22
R06.0
ICD-10 Finland
Dyspnoea
3.5
10.9
61
266
I42.1
ICD-10 Finland
Obstructive hypertrophic cardiomyopathy
+∞
10.6
10
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
35.9
10.6
13
*
TFP34
NOMESCO Finland
Electrophysiological investigation
35.9
10.6
13
*
81
HP
Angiography of the heart and coronary arteries
5.2
10.3
24
55
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.4
10.2
60
267
Z3231
NOMESCO Finland
Registered nurse
3.3
10.2
63
290
R4110
NOMESCO Finland
Physiotherapy
3.3
10.1
60
269
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.4
10.0
56
242
I42.8
ICD-10 Finland
Other cardiomyopathies
+∞
9.5
9
*
WX740
NOMESCO Finland
Nitrogen oxide therapy
+∞
9.5
9
*
4250A
ICD-9 Finland
Cardiomyopathy, Endomyocardial fibrosis
+∞
9.5
9
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.6
9.4
40
144
A10BK01
ATC
dapagliflozin; oral
5.2
9.2
21
47
ZXD05
NOMESCO Finland
Urgent procedure
3.2
9.0
53
233
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.7
9.0
35
119
I48.2
ICD-10 Finland
Chronic atrial fibrillation
5.4
8.9
19
40
G04BE03
ATC
sildenafil; oral
17.9
8.8
13
8
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
5.5
8.7
18
37
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
21.9
8.6
12
6
WX872
NOMESCO Finland
Intensive care
7.5
8.6
20
31
K84
ICPC
Heart disease other
12.0
8.6
15
14
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.4
8.4
18
38
B01AF02
ATC
apixaban; oral
3.6
8.3
33
113
GD1LA
NOMESCO Finland
GD
23.9
8.2
11
5
ZXE10
NOMESCO Finland
More than one and less than three hours
2.9
8.1
63
320
ZXD10
NOMESCO Finland
Scheduled procedure
2.9
7.9
66
348
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
7.8
38
148
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
4.4
7.6
21
55
H02AB06
ATC
prednisolone; systemic
2.8
7.5
77
448
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
84.9
7.5
8
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.8
7.5
18
42
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
4.3
7.4
21
56
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
7.4
54
263
C07AG02
ATC
carvedilol; oral
4.6
7.4
19
47
FQA10
NOMESCO Finland
Orthotopic transplantation of heart with bicaval anastomosis
+∞
7.4
7
*
XF620
NOMESCO Finland
Examination of circulation with color method
+∞
7.4
7
*
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
+∞
7.4
7
*
ZXE00
NOMESCO Finland
One hour or less
2.8
7.3
67
366
C09AA05
ATC
ramipril; oral
2.8
7.3
56
279
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
21.5
7.3
10
5
TK800
NOMESCO Finland
Hemodialysis
13.1
7.2
12
10
C10AA01
ATC
simvastatin; oral
2.8
7.1
77
456
JN3AD
NOMESCO Finland
Abdominal CT examination
3.5
7.1
28
95
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
14.9
7.0
11
8
R18
ICD-10 Finland
Ascites
11.9
7.0
12
11
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
7.9
6.9
15
21
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.2
6.9
16
25
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
6.8
43
193
A12BA01
ATC
potassium chloride; oral
4.4
6.7
18
46
AP1
HP
Catheterization of the left side of the heart
10.9
6.7
12
12
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.6
6.6
24
77
AP3
HP
Catheterization of the right and left side of the heart
73.4
6.5
7
*
AP2
HP
Catheterization of the right side of the heart
73.4
6.5
7
*
I27.0
ICD-10 Finland
Primary pulmonary hypertension
+∞
6.3
6
*
AP4
HP
Myocardial biopsy
+∞
6.3
6
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
7.4
6.2
14
21
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
6.7
6.2
15
25
I35.0
ICD-10 Finland
Aortic (valve) stenosis
3.9
6.0
19
55
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
420
8.08
23.93
16.8
3.3
3712.98
1837.73
ng/l
1.75
95
360
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
30
38
10.05
23.20
13.1
3.5
0.35
0.40
iu/ml
0.22
17
22
62
202
5.07
18.34
15.9
3.6
0.81
0.81
mmol/l
0.01
62
189
22
35
7.40
13.79
5.0
3.1
196.00
210.29
%
0.22
22
35
72
318
3.95
13.16
4.2
2.3
3.07
3.04
mg/l
0.04
61
279
22
39
6.62
12.44
8.7
3.8
86.27
92.33
%
0.69
22
39
64
296
3.36
10.26
5.5
3.2
422.35
349.10
umol/l
3.46
55
251
98
620
3.61
8.78
21.1
7.6
1.19
1.21
mmol/l
2.04
92
532
46
193
3.18
8.39
7.2
2.5
31.80
29.62
s
1.64
46
188
41
163
3.25
8.15
2.6
1.9
—
—
—
0
0
80
463
2.99
8.10
6.4
3.1
141.63
144.55
ug/l
0.05
75
422
45
191
3.11
7.99
13.8
6.9
102.93
104.02
mmol/l
0.68
45
191
15
18
9.29
7.57
2.0
1.4
10284.10
37425.00
e6/l
—
10
8
15
20
8.35
7.14
2.0
1.5
464.80
1016.36
e6/l
—
10
14
18
44
4.61
7.09
7.6
4.0
28.49
73.36
mg/l
0.45
18
38
18
44
4.61
7.09
7.6
4.0
89.29
81.25
mg/l
0.06
18
38
16
24
7.47
7.08
2.6
1.2
—
—
—
0
0
17
41
4.64
6.79
1.3
1.2
—
—
—
0
0
37
157
2.92
6.42
2.9
2.0
—
—
—
0
0
46
220
2.72
6.37
3.0
1.9
—
—
—
0
0
15
25
6.66
6.22
2.1
1.4
160.13
146.44
au/ml
—
8
9
27
97
3.27
6.21
1.6
1.6
—
—
—
0
0
52
269
2.59
6.11
5.0
2.5
—
—
—
0
0
15
26
6.40
6.06
2.2
1.4
—
—
—
0
0
17
45
4.21
6.04
23.8
6.2
2.09
1.58
mg/l
0.84
17
38
17
35
5.45
6.01
5.9
4.2
0.44
1.87
index
—
9
23
49
250
2.57
5.89
5.3
1.8
1.06
1.26
mg/l
0.37
44
204
77
493
2.44
5.56
9.2
4.0
97.84
51.55
ng/l
0.34
66
381
14
26
5.92
5.41
1.4
1.5
—
—
—
0
0
14
26
5.92
5.41
1.4
1.5
—
—
—
0
0
34
153
2.67
5.19
24.1
8.8
0.65
0.97
mmol/l
0.13
29
131
63
389
2.24
4.70
3.4
3.5
2.34
2.36
mmol/l
0.42
58
348
9
11
8.71
4.64
1.0
1.3
—
—
—
0
0
92
675
2.35
4.37
17.0
10.4
4.54
4.26
e9/l
0.47
83
580
59
363
2.18
4.36
5.2
3.4
1.12
0.46
e6/l
1.14
50
266
20
74
3.02
4.33
4.9
4.4
54.20
56.94
ml/min/173m2
—
10
32
22
87
2.85
4.24
10.3
4.2
2.46
1.97
mmol/l
0.26
14
57
10
18
5.93
4.06
1.2
1.2
—
—
—
0
0
10
18
5.93
4.06
1.3
1.3
135.90
216.48
u/l
—
10
18
20
77
2.90
4.04
2.8
1.7
—
—
—
0
0
40
220
2.20
3.83
1.9
1.7
1204.84
1178.99
nmol/l
0.05
35
168
25
112
2.54
3.79
42.5
8.2
25.04
24.67
mmol/l
0.20
25
112
40
221
2.19
3.79
4.3
3.1
2.18
0.91
e6/l
0.72
21
115
6
6
10.41
3.53
1.2
1.2
—
—
—
0
0
71
499
1.97
3.41
2.5
2.2
90.87
97.35
pmol/l
0.64
42
237
12
34
3.79
3.30
1.2
1.2
—
—
—
0
0
8
15
5.61
3.24
1.1
1.7
—
—
—
0
0
10
25
4.25
3.16
1.6
1.6
—
—
—
0
0
15
57
2.85
3.09
2.7
1.7
0.44
5.55
ug/l
0.55
15
52
6
8
7.80
3.09
1.3
2.6
—
—
—
0
0
11
32
3.66
2.98
1.3
1.8
—
—
—
0
0
17
71
2.61
2.95
9.7
3.3
0.62
0.65
%
0.15
17
71
17
72
2.57
2.87
9.7
3.3
1.06
1.16
%
0.23
17
72
12
41
3.13
2.71
1.8
1.5
—
—
—
0
0
7
15
4.87
2.63
1.1
1.7
—
—
—
0
0
8
20
4.20
2.61
1.5
1.8
—
—
—
0
0
5
7
7.38
2.57
2.2
1.1
221.80
555.00
mg
—
5
7
97
797
1.94
2.53
8.8
4.5
16.09
13.75
mm/h
0.89
92
725
36
219
1.90
2.53
4.8
3.2
2.76
1.34
e6/l
0.86
17
112
5
8
6.45
2.39
1.4
2.4
—
—
—
0
0
5
8
6.45
2.39
1.4
2.4
—
—
—
0
0
5
9
5.73
2.23
5.4
1.3
3.58
3.00
mg/l
—
5
9
69
527
1.68
2.16
5.8
2.9
—
—
estimate
—
0
0
7
20
3.64
2.08
1.0
1.3
—
207.87
—
0
6
10
39
2.70
1.99
1.6
1.4
—
—
—
0
0
10
39
2.70
1.99
1.8
1.5
—
—
—
0
0
63
481
1.62
1.90
4.7
2.6
79.34
76.66
nmol/l
0.28
58
423
5
13
3.96
1.73
1.8
1.4
—
—
—
0
0
5
13
3.96
1.73
1.8
1.4
—
—
—
0
0
5
13
3.96
1.73
1.8
1.4
—
—
—
0
0
10
40
2.63
1.71
1.8
1.5
—
—
—
0
0
6
19
3.26
1.68
10.5
1.7
20.55
3.46
mg/l
—
6
14
49
363
1.57
1.62
1.9
1.8
16.98
21.00
nmol/l
1.76
42
293
6
20
3.10
1.60
2.2
1.6
—
—
—
0
0
7
27
2.68
1.54
21.9
3.3
6.00
10.69
pmol/l
—
7
27
6
21
2.95
1.52
2.8
2.5
21.17
16.98
ug/l
—
6
21
7
29
2.49
1.41
1.0
1.4
—
—
—
0
0
13
72
1.90
1.20
1.5
1.3
—
—
—
0
0
34
253
1.47
1.06
1.4
1.4
0.35
1.04
u/ml
—
6
72
111
1034
1.62
0.94
50.9
18.6
22.15
26.08
mg/l
1.07
105
890
18
120
1.58
0.91
4.4
3.9
—
—
—
0
0
6
29
2.12
0.90
2.3
1.7
—
—
—
0
0
8
46
1.79
0.84
2.3
2.5
—
—
—
0
0
6
33
1.86
0.80
1.2
1.4
1.08
1.09
g/l
—
6
33
6
33
1.86
0.80
1.2
1.3
0.21
0.22
g/l
—
6
33
0
24
0.00
0.80
0.0
1.2
—
1.97
—
0
13
0
27
0.00
0.78
0.0
1.7
—
—
—
0
0
86
776
1.34
0.77
6.0
4.1
15.55
15.02
pmol/l
0.92
81
692
20
270
0.69
0.75
3.3
3.2
1.01
0.75
ug/l
0.52
14
167
5
25
2.04
0.73
1.6
1.2
—
—
—
0
0
5
26
1.96
0.71
1.4
1.6
—
—
—
0
0
70
622
1.28
0.66
6.4
4.2
0.00
0.00
estimate
-0.00
20
141
7
44
1.62
0.66
3.7
1.8
—
—
—
0
0
7
44
1.62
0.66
3.9
2.0
—
—
—
0
0
0
20
0.00
0.61
0.0
1.1
—
1.07
—
0
8
16
116
1.43
0.58
21.6
8.3
—
—
—
0
0
70
631
1.25
0.55
6.4
4.3
0.00
0.03
estimate
0.50
18
135
46
396
1.25
0.54
3.5
4.2
18.95
10.44
mg/mmol
0.40
34
259
30
359
0.78
0.51
7.7
3.9
0.00
0.00
estimate
-0.00
17
114
20
156
1.34
0.49
1.2
1.3
1.12
4.05
u/ml
—
6
57
69
630
1.21
0.45
6.5
4.2
0.00
0.00
estimate
-0.00
20
148
8
55
1.48
0.44
1.4
2.6
13.00
1417.20
u/ml
—
8
44
5
32
1.59
0.42
1.4
1.5
—
—
—
0
0
98
930
1.24
0.41
7.3
5.2
2.53
2.04
mu/l
1.49
93
834
5
34
1.49
0.41
1.2
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
5
35
1.45
0.40
1.2
1.2
—
—
—
0
0
23
269
0.82
0.31
5.6
4.4
1.02
1.02
kg/l
0.30
18
187
111
1080
1.23
0.26
67.0
24.8
114.69
82.67
umol/l
3.56
111
1066
100
965
1.18
0.26
5.8
5.4
6.33
6.14
mmol/l
0.37
89
876
60
563
1.13
0.23
3.4
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
32
352
0.88
0.21
4.1
4.4
23.25
20.63
%
0.54
11
176
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
45
480
0.90
0.18
7.2
4.3
0.06
0.03
estimate
0.20
18
116
5
67
0.74
0.17
1.4
2.2
3.06
3.35
ratio
—
5
54
39
365
1.10
0.15
5.5
4.2
0.00
0.02
estimate
0.50
18
133
42
445
0.92
0.14
4.8
5.6
2.34
2.72
ug/l
0.17
36
396
5
44
1.14
0.10
1.2
1.3
—
—
—
0
0
15
140
1.08
0.04
1.5
1.5
—
—
—
0
0
111
1100
1.08
0.04
75.0
28.5
122.63
133.34
g/l
8.59
111
1089
111
1100
1.08
0.04
72.9
28.0
92.00
91.10
fl
1.16
111
1090
111
1100
1.08
0.04
80.2
28.8
37.63
39.86
%
4.83
111
1090
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.4
—
9.80
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
19.00
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
6.27
—
0
6
7
72
0.97
-0.00
1.1
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
116.52
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
1848.80
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
9.40
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
50.95
—
0
6
9
98
0.91
-0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.4
—
4.65
—
0
7
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYORESTR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYORESTR | 3.454 [2.39, 4.98] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.374 |
During the follow-up period (1.1.1998 — 31.12.2019), 141 out of 266 females with I9_CARDMYORESTR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYORESTR | 3.473 [2.16, 5.58] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 218 males with I9_CARDMYORESTR died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYORESTR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.452% | 0.712% |
| 5 | 2.057% | 3.886% |
| 10 | 5.061% | 10.332% |
| 15 | 9.883% | 18.825% |
| 20 | 17.043% | 30.526% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYORESTR – Restrictive cardiomyopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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