cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
245 |
4. Check minimum number of eventsNone |
245 |
5. Include endpointsNone |
245 |
6. Filter based on genotype QC (FinnGen only) |
214 |
Control definitions (FinnGen only)
- Control exclude
- I9_OTHHEART
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Cardiomyopathy in other diseases
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy
- Other heart diseases, wide
- Cardiovascular diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1290 | 549 | 728 |
| Only index persons | 1090 | 458 | 632 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 75.24 | 77.02 | 73.83 |
| Only index persons | 75.15 | 76.96 | 73.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 214 | 71 | 143 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.07 |
| Median age at first event (years) | 74.08 | 71.34 | 75.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 218
- Matched controls
- 2180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I50.9
ICD-10 Finland
Heart failure, unspecified
181.8
248.6
125
16
I48
ICD-10 Finland
Atrial fibrillation and flutter
256.1
244.6
118
10
I43.1*E85.9
ICD-10 Finland
Cardiac amyloidosis
+∞
165.4
137
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
101.1
89
*
C03DA01
ATC
spironolactone; oral
19.2
100.2
98
89
C03CA01
ATC
furosemide; systemic
21.8
98.7
181
400
207
Kela drug reimbursment
Chronic arrhythmias
+∞
98.6
87
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
94.9
84
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
47.9
93.7
57
16
B01AF02
ATC
apixaban; oral
22.0
82.2
68
44
I50.0
ICD-10 Finland
Congestive heart failure
1083.3
79.6
73
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
11.1
70.8
107
174
E85.9
ICD-10 Finland
Amyloidosis, unspecified
+∞
66.1
60
*
M04AA01
ATC
allopurinol; systemic
10.2
65.5
107
189
I43.8*M10.0
ICD-10 Finland
Gout in the heart
+∞
61.4
56
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
9.7
59.4
94
158
B01AA03
ATC
warfarin; systemic
9.9
56.0
83
128
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
606.7
50.6
48
*
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
305.8
49.2
48
*
XF404
NOMESCO Finland
Ambulatory ECG
16.0
45.6
42
32
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
7.0
45.3
105
256
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
273.9
44.7
44
*
C07AB07
ATC
bisoprolol; oral
8.2
44.7
169
647
TFP20
NOMESCO Finland
Cardiodefibrillation
+∞
42.1
39
*
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
+∞
40.9
38
*
E85.4
ICD-10 Finland
Organ-limited amyloidosis
+∞
40.9
38
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
10.4
38.0
47
56
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
423.7
37.2
36
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
409.6
36.1
35
*
I50.1
ICD-10 Finland
Left ventricular failure
390.7
33.9
33
*
M10.9
ICD-10 Finland
Gout, unspecified
7.5
32.0
53
89
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.7
31.3
162
732
M10
ICD-10 Finland
Gout
10.9
30.9
36
39
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.7
30.8
74
179
XW000
NOMESCO Finland
Bone marrow biopsy
9.4
30.4
40
51
R06.0
ICD-10 Finland
Dyspnoea
5.0
30.1
103
334
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
+∞
29.9
28
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.9
28.6
39
52
I48.1
ICD-10 Finland
Persistent atrial fibrillation
320.4
28.4
28
*
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
27.7
26
*
250, ,
Kela drug reimbursment
306.8
27.4
27
*
I48.2
ICD-10 Finland
Chronic atrial fibrillation
306.8
27.4
27
*
E85.89
ICD-10 Finland
Other amyloidosis
+∞
25.5
24
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
+∞
25.5
24
*
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
25.5
24
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
10.9
24.6
28
29
I43.1
ICD-10 Finland
Cardiomyopathy in metabolic diseases
+∞
24.4
23
*
M10.0
ICD-10 Finland
Idiopathic gout
10.3
24.4
29
32
A10BK01
ATC
dapagliflozin; oral
7.2
24.2
40
66
I49.5
ICD-10 Finland
Sick sinus syndrome
98.0
24.2
26
*
I50
ICD-10 Finland
Heart failure
98.0
24.2
26
*
C90.0
ICD-10 Finland
Multiple myeloma
29.9
23.4
31
12
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.2
22.1
84
285
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
7.1
21.4
35
57
XF402
NOMESCO Finland
ECG with work load test
5.8
20.7
43
89
N07XX08
ATC
tafamidis; oral
+∞
20.1
19
*
WX892
NOMESCO Finland
Monitored bed care
6.6
20.0
35
61
A46
ICD-10 Finland
Erysipelas
4.4
19.6
62
182
3011
Kela drug reimbursment
Tafamidis
+∞
19.0
18
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
+∞
19.0
18
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
8.3
18.7
26
35
K78
ICPC
Atrial fibrillation/flutter
20.9
17.8
26
14
153
Kela drug reimbursment
Lenalidomid
46.2
17.6
21
5
C01AA05
ATC
digoxin; systemic
17.9
17.5
27
17
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
28.3
17.3
23
9
C09AA05
ATC
ramipril; oral
3.4
17.1
93
390
TFJ02
NOMESCO Finland
Muscle biopsy of heart
+∞
16.9
16
*
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
+∞
16.9
16
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
+∞
16.9
16
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
16.5
53
156
XF400
NOMESCO Finland
ECG with 12 standard connections
3.9
15.9
57
181
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
171.8
15.7
16
*
A10BK03
ATC
empagliflozin; oral
4.4
15.4
44
118
C01BD01
ATC
amiodarone; systemic
86.0
14.8
16
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
39.0
14.7
18
5
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
160.3
14.6
15
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.1
14.4
46
134
L04AX04
ATC
lenalidomide; oral
45.9
14.3
17
*
329
Kela drug reimbursment
Lenalidomide
57.2
14.0
16
*
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
13.7
13
*
B01AF01
ATC
rivaroxaban; oral
4.0
13.6
45
134
I44.1
ICD-10 Finland
Atrioventricular block, second degree
148.9
13.6
14
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.1
13.6
31
69
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
10.4
13.4
26
28
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.7
13.4
50
162
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.9
13.2
45
137
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.3
12.9
37
99
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
6.2
12.7
23
41
I47.2
ICD-10 Finland
Ventricular tachycardia
+∞
12.6
12
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.9
12.5
84
386
N19
ICD-10 Finland
Unspecified kidney failure
6.5
12.4
21
35
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
15.9
12.0
19
13
I47.1
ICD-10 Finland
Supraventricular tachycardia
49.6
12.0
14
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
5.0
11.8
27
60
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.7
11.7
29
69
N08.4*E85.9
ICD-10 Finland
Glomerular disorders in amyloidosis
+∞
11.6
11
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
37.2
11.4
14
*
A04AA01
ATC
ondansetron; systemic, rectal
3.9
11.3
36
104
R07.4
ICD-10 Finland
Chest pain, unspecified
2.8
11.0
78
365
B01AB05
ATC
enoxaparin; parenteral
2.7
11.0
90
453
J05AB01
ATC
aciclovir; systemic
2.9
10.9
65
277
ACC51
NOMESCO Finland
Release of median nerve
4.1
10.9
32
87
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
10.9
106
581
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
63.2
10.7
12
*
H02AB02
ATC
dexamethasone; systemic
3.2
10.6
48
175
GD1LA
NOMESCO Finland
GD
115.3
10.5
11
*
R02
ICPC
Shortness of breath/dyspnoea
3.6
10.5
39
125
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
34.4
10.5
13
*
A02BC02
ATC
pantoprazole; systemic
2.9
10.4
166
1146
K07
ICPC
Swollen ankles/oedema
5.4
10.3
21
42
R55
ICD-10 Finland
Syncope and collapse
3.4
9.9
40
135
K77
ICPC
Heart failure
27.5
9.9
13
5
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.7
9.9
71
332
H02AB06
ATC
prednisolone; systemic
2.5
9.9
121
729
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.1
9.8
48
182
R4110
NOMESCO Finland
Physiotherapy
2.6
9.8
78
384
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
9.7
41
143
C02AC05
ATC
moxonidine; oral
5.1
9.3
20
42
R50.9
ICD-10 Finland
Fever, unspecified
3.0
9.1
46
178
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
9.1
61
275
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.5
9.0
34
110
I34.1
ICD-10 Finland
Mitral (valve) prolapse
52.1
8.7
10
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.3
8.7
36
123
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.9
8.7
27
76
AA1AD
NOMESCO Finland
CT of head and brain
2.4
8.6
84
450
R60.0
ICD-10 Finland
Localized oedema
3.0
8.5
42
160
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
93.5
8.5
9
*
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
93.5
8.5
9
*
A10BH05
ATC
linagliptin; oral
4.2
8.4
23
59
1XX32, ,
NOMESCO Finland
+∞
8.4
8
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
15.3
8.3
13
9
AN1
HP
Coronary angiography
3.2
8.3
36
127
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
8.3
36
127
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
8.7
8.3
17
21
M13.9
ICD-10 Finland
Arthritis, unspecified
3.8
8.3
27
79
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
8.1
80
429
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
7.1
8.1
19
29
R00.0
ICD-10 Finland
Tachycardia, unspecified
10.0
7.9
15
16
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
11.4
7.9
14
13
J94.8
ICD-10 Finland
Other specified pleural conditions
11.4
7.9
14
13
ZXA00
NOMESCO Finland
Right side
2.4
7.9
74
388
L01AA03
ATC
melphalan; systemic
46.7
7.8
9
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.5
7.7
16
20
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
7.6
78
423
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
82.8
7.5
8
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.2
7.3
20
51
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
7.3
90
525
AP4
HP
Myocardial biopsy
+∞
7.3
7
*
L01FC01
ATC
daratumumab; parenteral
+∞
7.3
7
*
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
+∞
7.3
7
*
I43.8*E05.9
ICD-10 Finland
Thyrotoxic heart disease
+∞
7.3
7
*
ZX112
NOMESCO Finland
Subcutaneous
6.7
7.1
17
27
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
4.6
7.1
17
39
ZXD05
NOMESCO Finland
Urgent procedure
2.3
7.1
69
365
Z3231
NOMESCO Finland
Registered nurse
2.3
7.1
73
396
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
8.7
6.9
14
17
ZXA05
NOMESCO Finland
Left side
2.3
6.9
70
376
J01CA04
ATC
amoxicillin; systemic
2.4
6.8
166
1255
AA1AA
NOMESCO Finland
Head X-ray examination
17.4
6.8
10
6
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
6.7
46
207
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
4.4
6.7
17
41
SPAT1104
SPAT
Monitoring of emergency patient
3.7
6.6
22
65
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
6.5
42
183
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
6.5
42
183
B01AE07
ATC
dabigatran etexilate; oral
7.8
6.5
14
19
H02AB07
ATC
prednisone; oral
2.6
6.5
40
171
N03AX16
ATC
[U] pregabalin
2.3
6.5
58
295
NF1AA
NOMESCO Finland
Hip X-ray examination
2.8
6.4
34
134
A11CC03
ATC
alfacalcidol; systemic
11.5
6.4
11
10
Z3226
NOMESCO Finland
Physiotherapist
2.4
6.3
49
233
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
5.7
6.3
17
32
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
6.3
6
*
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
27.5
6.3
8
*
R53
ICD-10 Finland
Malaise and fatigue
2.3
6.3
59
306
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
4.0
6.2
18
48
S97
ICPC
Chronic ulcer skin
3.4
6.1
22
69
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.3
6.0
17
34
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
108
58
35.92
146.73
12.8
2.5
37.20
51.09
mg/l
0.82
93
50
106
58
34.63
142.64
13.0
2.5
60.19
53.13
mg/l
0.12
91
51
101
54
33.99
136.81
12.1
2.6
1.61
2.48
ratio
0.50
68
35
124
155
17.23
104.08
8.4
2.3
63.58
66.75
g/l
3.07
117
139
171
480
12.89
70.00
13.1
1.9
4825.84
470.22
ng/l
16.73
162
405
74
77
14.04
67.69
7.5
2.0
4.00
4.06
g/l
0.21
69
68
74
77
14.04
67.69
7.5
2.0
3.24
3.56
g/l
1.05
69
68
74
77
14.04
67.69
7.5
2.0
7.12
7.56
g/l
0.87
69
68
70
73
13.65
63.70
7.9
2.0
2.72
3.03
g/l
1.19
65
64
68
70
13.66
62.33
7.9
2.1
0.66
0.98
g/l
0.26
57
60
65
67
13.40
59.37
7.7
2.1
8.14
10.90
g/l
3.51
59
57
55
57
12.57
49.61
7.9
2.2
0.00
0.00
g/l
-0.00
47
51
55
58
12.35
49.00
7.9
2.2
0.01
0.09
g/l
0.40
49
52
99
219
7.45
47.40
7.7
4.3
1.12
0.99
mmol/l
4.30
94
203
104
265
6.59
42.42
3.6
1.9
2.33
2.23
g/l
0.90
98
234
123
460
4.84
29.92
6.8
2.6
414.15
351.10
umol/l
5.18
109
381
53
98
6.82
29.07
6.4
1.7
472.11
115.69
ng/l
3.14
53
84
94
293
4.88
28.69
4.2
3.8
0.81
0.82
mmol/l
0.15
88
269
96
317
4.62
26.95
2.7
1.7
—
—
—
0
0
36
18
23.68
25.33
3.5
1.4
772.11
572.17
mg
0.33
36
18
114
453
4.18
24.41
2.8
2.1
3.05
2.96
mg/l
0.13
98
379
145
685
4.34
24.20
4.4
2.5
142.48
178.04
ug/l
1.40
135
621
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
31
38
9.34
24.13
3.7
2.5
0.39
0.41
iu/ml
0.09
16
19
161
829
4.60
23.58
12.1
4.5
33.90
34.91
g/l
1.27
154
777
144
693
4.18
23.02
11.2
3.1
74.24
159.05
ng/l
0.49
129
543
54
133
5.07
21.39
3.0
2.1
5.08
5.06
ug/l
0.01
44
115
159
846
4.25
21.37
15.9
4.9
1.20
1.21
mmol/l
2.84
150
768
165
922
4.25
20.15
10.3
7.1
14.39
11.87
umol/l
1.97
160
877
63
186
4.36
19.78
6.1
4.8
0.58
1.05
mmol/l
0.33
54
150
72
235
4.08
19.72
2.3
1.5
—
—
—
0
0
169
973
4.28
19.44
18.3
9.7
4.42
4.22
e9/l
0.59
153
829
57
162
4.41
18.74
4.8
3.7
2.16
2.05
mmol/l
0.08
51
133
165
958
3.97
18.19
18.6
5.8
1.20
1.21
mmol/l
2.97
148
820
62
192
4.12
18.12
3.5
3.1
10.27
7.20
umol/l
0.53
53
175
29
22
15.01
17.55
1.8
1.5
24.21
37.44
g/l
3.92
24
22
49
130
4.57
17.52
1.9
1.6
—
—
—
0
0
66
219
3.89
17.44
2.4
1.5
—
—
—
0
0
50
137
4.44
17.13
4.1
2.7
111.33
80.07
ng/l
1.59
45
120
81
318
3.46
16.48
14.3
3.0
267.44
267.25
ng/l
0.00
81
263
166
1032
3.55
15.05
10.3
4.1
6.75
6.85
mmol/l
0.30
160
982
84
356
3.21
14.85
2.1
1.9
0.94
1.68
mg/l
2.85
61
293
51
160
3.86
14.39
2.5
3.1
0.18
0.21
g/l
1.52
46
154
40
109
4.27
13.65
6.9
5.4
94.57
94.22
%
0.21
40
109
39
107
4.22
13.18
7.1
5.4
0.54
0.67
%
1.04
39
107
63
242
3.25
12.91
9.4
5.4
103.57
104.10
mmol/l
0.33
63
242
106
551
2.80
12.51
4.3
2.1
191.46
193.83
u/l
0.01
97
518
34
90
4.29
12.00
1.5
1.8
1.28
1.52
g/l
0.90
27
79
38
111
3.94
11.74
7.2
5.3
1.17
1.45
%
0.96
38
111
42
132
3.70
11.69
2.3
1.4
—
—
—
0
0
47
160
3.47
11.60
2.1
2.0
479.45
30.17
u/l
0.49
40
133
19
15
13.75
11.38
1.6
1.5
121.68
302.60
u/l
1.74
19
15
21
21
10.94
11.29
1.6
1.3
712.20
836.83
e6/l
0.12
15
12
14
5
29.74
10.86
1.1
2.2
—
—
—
0
0
20
20
10.89
10.76
1.6
1.4
5940.78
70786.67
e6/l
—
9
9
23
30
8.44
10.71
1.2
1.2
—
—
—
0
0
93
504
2.47
9.47
4.1
3.3
39.14
31.51
u/l
0.80
86
478
81
419
2.48
9.05
3.4
2.6
—
—
—
0
0
33
105
3.53
8.94
5.4
3.1
1.89
1.84
mmol/l
0.03
25
77
25
67
4.09
8.62
1.3
1.2
—
—
—
0
0
19
28
7.33
8.27
1.5
1.3
—
—
—
0
0
19
28
7.33
8.27
1.5
1.3
—
—
—
0
0
20
47
4.58
8.13
1.8
1.4
—
—
—
0
0
16
21
8.13
7.53
1.1
1.1
—
—
—
0
0
15
19
8.39
7.23
1.4
1.1
—
—
—
0
0
10
5
20.85
7.20
3.0
1.4
424.40
1441.00
u/ml
—
10
5
18
31
6.23
7.09
1.1
1.5
—
—
—
0
0
94
564
2.17
7.08
4.1
3.4
1.03
0.37
e6/l
1.33
75
428
18
33
5.85
6.78
2.4
1.7
—
—
—
0
0
18
45
4.27
6.77
1.7
1.2
—
—
—
0
0
22
64
3.71
6.76
1.9
1.6
9.34
9.89
iu/ml
—
5
19
20
55
3.90
6.64
2.0
1.3
—
—
—
0
0
15
22
7.24
6.64
1.1
1.3
107.00
134.43
au/ml
—
6
8
165
1257
2.29
6.45
7.2
4.3
20.55
13.38
mm/h
3.31
160
1144
119
807
2.05
6.26
3.7
2.8
—
—
estimate
—
0
0
65
353
2.20
6.16
3.8
3.2
0.89
1.04
e6/l
0.24
37
201
10
8
13.02
6.14
2.8
1.0
39.07
41.51
g/l
—
10
8
16
29
5.87
6.12
2.4
1.8
—
—
—
0
0
11
11
10.46
6.10
2.8
3.5
—
—
—
0
0
15
26
6.11
5.95
1.9
1.3
—
—
—
0
0
62
335
2.19
5.92
3.9
3.4
2.63
1.14
e6/l
0.74
33
183
22
71
3.33
5.80
2.2
1.6
—
—
—
0
0
100
650
1.99
5.80
5.2
4.1
45.94
5.50
mg/mmol
2.54
84
401
18
51
3.76
5.74
1.4
2.0
—
—
—
0
0
88
550
2.01
5.67
3.3
2.5
54.45
62.95
u/l
0.50
78
507
89
559
2.00
5.66
2.1
1.7
22.36
19.95
nmol/l
0.73
79
457
9
7
13.34
5.63
1.0
1.7
—
—
—
0
0
11
13
8.84
5.63
1.0
1.1
—
—
—
0
0
120
843
1.94
5.44
2.7
2.2
94.77
92.11
pmol/l
0.26
75
431
22
74
3.19
5.43
2.5
1.7
1.21
6.62
ug/l
0.74
17
64
153
1169
2.04
5.41
4.9
3.8
15.45
14.99
pmol/l
1.19
136
1016
10
11
9.46
5.34
2.5
2.5
1.10
0.91
index
—
10
11
11
15
7.66
5.21
1.5
1.4
4.82
10.93
u/l
2.06
11
15
13
23
5.94
5.15
1.5
3.6
34.31
32.52
pg
0.90
13
23
11
16
7.18
5.02
2.1
1.3
—
—
—
0
0
12
20
6.28
4.99
2.1
1.4
—
—
—
0
0
9
10
9.33
4.83
1.4
1.6
16.67
11.00
u/l
—
9
10
191
1618
2.46
4.76
47.6
15.7
25.49
28.31
mg/l
0.68
178
1339
21
75
2.99
4.70
3.1
1.8
—
—
—
0
0
50
270
2.11
4.70
1.4
1.3
15.09
38.48
iu/ml
2.45
19
92
96
651
1.85
4.64
4.2
3.5
2.33
2.36
mmol/l
1.02
81
585
11
19
6.04
4.50
2.6
2.1
—
—
—
0
0
127
955
1.79
4.23
4.7
3.2
86.64
55.02
u/l
2.28
118
875
107
769
1.77
4.13
3.3
2.4
—
—
—
0
0
63
388
1.88
4.03
1.7
1.7
1066.98
1111.21
nmol/l
0.09
46
294
14
37
3.97
3.97
1.6
1.5
—
—
—
0
0
176
1488
1.95
3.73
6.6
4.7
2.33
2.04
mu/l
1.85
160
1301
24
107
2.40
3.54
1.4
1.3
—
—
—
0
0
8
13
6.34
3.53
2.6
2.1
—
—
—
0
0
8
13
6.34
3.53
2.6
2.1
—
—
—
0
0
16
60
2.80
3.31
2.4
2.4
—
—
—
0
0
17
66
2.71
3.30
1.2
1.1
72.95
132.50
u/ml
—
6
25
20
86
2.46
3.19
4.2
3.7
0.72
0.64
%
0.48
20
86
10
25
4.14
3.12
1.9
1.4
—
—
—
0
0
13
41
3.31
3.11
1.7
1.4
—
—
—
0
0
20
87
2.43
3.11
4.2
3.7
1.05
1.23
%
0.57
20
87
175
1507
1.82
3.09
5.5
4.4
1.22
1.25
mmol/l
0.30
160
1335
6
8
7.67
3.07
2.7
2.4
—
—
—
0
0
6
8
7.67
3.07
2.7
2.4
—
—
—
0
0
6
8
7.67
3.07
2.7
2.4
—
—
—
0
0
7
12
5.99
3.04
1.3
1.1
—
—
—
0
0
5
5
10.19
2.99
3.0
3.0
—
—
—
0
0
5
5
10.19
2.99
3.0
3.0
—
—
—
0
0
5
5
10.19
2.99
3.0
3.0
—
—
—
0
0
44
266
1.82
2.93
1.3
1.3
3.03
16.18
u/ml
1.43
11
94
117
916
1.60
2.92
3.9
3.8
0.00
0.00
estimate
-0.00
22
211
6
9
6.82
2.88
1.2
1.0
—
—
—
0
0
6
9
6.82
2.88
1.3
1.4
—
—
—
0
0
52
332
1.74
2.88
1.3
1.2
0.75
1.49
u/ml
—
8
78
33
185
1.92
2.76
5.8
3.4
—
—
—
0
0
5
6
8.49
2.76
3.0
2.8
—
—
—
0
0
5
6
8.49
2.76
3.0
2.8
—
—
—
0
0
5
6
8.49
2.76
3.0
2.8
—
—
—
0
0
5
6
8.49
2.76
3.0
2.8
—
—
—
0
0
117
927
1.57
2.70
4.0
3.8
0.04
7.45
estimate
0.49
23
218
8
19
4.33
2.70
1.0
1.1
—
—
—
0
0
12
43
2.90
2.69
1.3
1.6
0.16
0.10
iu/ml
—
5
9
5
7
7.28
2.56
1.8
1.6
—
—
—
0
0
5
7
7.28
2.56
1.8
1.6
—
—
—
0
0
6
11
5.57
2.56
1.0
1.0
270.17
316.82
mg/l
—
6
11
12
45
2.76
2.49
1.1
1.2
—
—
—
0
0
11
38
2.99
2.45
1.2
1.2
—
2.16
—
0
5
177
1564
1.70
2.43
8.4
7.1
40.95
40.00
mmol/mol
0.86
167
1426
99
769
1.53
2.42
2.8
2.2
76.23
78.88
nmol/l
0.47
92
672
5
8
6.36
2.38
1.4
1.5
—
—
—
0
0
5
8
6.36
2.38
1.4
1.5
—
—
—
0
0
17
78
2.28
2.38
7.1
3.9
1.68
1.34
%
1.41
17
73
116
937
1.51
2.33
4.0
3.8
0.00
0.02
estimate
0.50
18
202
12
47
2.64
2.31
1.1
1.4
847.43
273.32
ug/g
—
7
22
6
13
4.71
2.28
1.0
1.2
—
—
—
0
0
5
9
5.65
2.22
1.2
1.0
130.60
178.11
u/l
—
5
9
5
9
5.65
2.22
1.8
1.6
—
—
—
0
0
5
9
5.65
2.22
1.2
1.0
50.00
85.44
u/l
—
5
9
5
9
5.65
2.22
1.8
1.6
—
—
—
0
0
35
215
1.75
2.21
15.4
6.3
—
—
—
0
0
177
1585
1.62
2.06
6.3
5.2
4.04
4.49
mmol/l
7.15
164
1432
73
547
1.50
2.05
3.0
3.5
0.71
0.77
ug/l
0.26
50
404
176
1576
1.61
2.03
6.3
5.1
1.32
1.44
mmol/l
3.12
163
1413
12
51
2.43
1.98
1.2
1.2
—
—
—
0
0
12
51
2.43
1.98
1.2
1.2
—
—
—
0
0
10
39
2.64
1.97
1.2
1.3
5.80
85.79
e6/l
—
10
29
6
17
3.60
1.85
1.8
1.5
—
—
—
0
0
58
423
1.51
1.84
3.3
3.0
2.48
2.47
mmol/l
0.27
47
378
179
1621
1.58
1.83
7.5
6.1
2.25
2.61
mmol/l
6.48
169
1460
177
1605
1.55
1.74
6.7
5.5
6.10
6.09
mmol/l
0.03
159
1439
10
41
2.51
1.66
1.3
1.4
65.20
238.39
e6/l
—
10
33
13
63
2.13
1.63
1.2
1.2
—
—
—
0
0
10
44
2.33
1.58
3.2
3.0
3.94
3.89
mmol/l
—
10
44
5
15
3.39
1.53
1.2
1.1
—
—
—
0
0
6
21
2.91
1.51
5.8
1.9
16.87
8.89
pmol/l
—
6
21
109
919
1.37
1.51
5.8
6.0
2.47
2.96
ug/l
0.45
95
823
24
149
1.69
1.48
1.3
1.6
1.80
1.68
%
0.15
17
128
19
110
1.80
1.48
2.9
3.5
39.70
63.50
ml/min/173m2
—
10
50
11
52
2.17
1.47
3.3
4.1
1.36
1.61
mmol/l
0.33
11
52
90
739
1.37
1.46
4.5
5.0
20.76
21.79
%
0.22
42
429
9
42
2.19
1.35
1.8
1.5
—
—
—
0
0
5
21
2.41
1.09
1.8
1.5
—
—
—
0
0
5
23
2.20
0.98
1.0
1.2
0.26
0.20
nmol/l
—
5
15
32
237
1.41
0.95
5.7
5.2
34.35
32.53
%
0.31
23
139
171
1599
1.32
0.92
45.3
15.8
62.62
74.65
ml/min/173m2
9.61
166
1495
8
46
1.77
0.83
5.3
1.8
119.13
130.28
g/l
—
8
32
25
182
1.42
0.82
1.2
1.3
—
—
—
0
0
7
41
1.73
0.70
1.7
1.3
—
—
—
0
0
32
252
1.32
0.67
2.8
4.8
2.76
41.58
ug/l
0.84
27
214
21
158
1.36
0.60
13.3
3.8
1.21
1.22
mmol/l
0.98
21
135
5
88
0.56
0.57
3.0
2.1
5.28
3.49
ratio
—
5
73
13
97
1.36
0.40
1.6
3.5
13.12
3102.60
u/ml
1.03
13
83
7
54
1.31
0.30
1.6
1.3
—
—
—
0
0
8
66
1.22
0.27
1.1
1.1
—
—
—
0
0
61
655
0.90
0.24
2.0
1.9
1.35
1.29
mmol/l
0.19
53
523
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
203.82
—
0
10
13
108
1.22
0.20
4.6
4.4
1.02
1.02
ratio
0.75
13
102
15
127
1.19
0.20
1.5
1.5
—
—
—
0
0
67
702
0.93
0.15
4.7
3.9
0.00
0.00
estimate
-0.00
17
171
56
539
1.05
0.09
4.6
3.8
0.00
0.00
estimate
-0.00
17
188
19
176
1.09
0.08
2.5
2.8
0.35
0.30
e6/l
0.15
19
169
38
397
0.95
0.07
5.2
4.0
1.02
1.02
kg/l
0.86
29
267
45
434
1.05
0.06
1.6
1.8
464.82
15702875.56
pmol/l
0.50
34
363
12
131
0.91
0.06
2.0
1.4
—
—
—
0
0
50
504
0.99
0.00
3.6
3.3
0.00
0.00
estimate
-0.00
17
168
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
11.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
1.16
—
0
5
0
5
0.00
-0.00
0.0
3.0
—
13.34
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYOINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOINOTH | 2.876 [2.14, 3.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.266 |
During the follow-up period (1.1.1998 — 31.12.2019), 309 out of 468 females with I9_CARDMYOINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOINOTH | 3.006 [2.13, 4.25] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 575 males with I9_CARDMYOINOTH died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYOINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | 0.544% |
| 5 | 1.524% | 3.482% |
| 10 | 4.342% | 8.284% |
| 15 | 8.369% | 15.119% |
| 20 | 14.153% | 24.199% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYOINOTH – Cardiomyopathy in other diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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