No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
741 |
4. Check minimum number of eventsNone |
741 |
5. Include endpointsNone |
741 |
6. Filter based on genotype QC (FinnGen only) |
658 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H61
- Name in latin
- Perichondritis auris externae
Similar endpoints
↥List of similar endpoints to
Perichondritis of external ear
based on the number of shared cases.
Similar with more cases:
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4952 | 2479 | 2432 |
| Only index persons | 4192 | 2180 | 2012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 49.13 | 53.02 | 45.11 |
| Only index persons | 47.52 | 51.82 | 42.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 658 | 356 | 302 |
| Unadjusted period prevalence (%) | 0.13 | 0.13 | 0.14 |
| Median age at first event (years) | 49.69 | 51.97 | 47.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 674
- Matched controls
- 6740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H61.0
ICD-10 Finland
Perichondritis of external ear
7936.1
307.7
387
*
38798
ICD-8 Finland
Other disease of ear and mastoid process, Alii definiti
+∞
278.0
247
*
DAB00
NOMESCO Finland
Excision of lesion of auricle
20.2
69.0
54
29
3800A
ICD-9 Finland
Disorders of external ear, Perichondritis of pinna
+∞
50.7
48
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.5
30.1
119
390
H60.9
ICD-10 Finland
Otitis externa, unspecified
4.5
27.8
72
174
H61.2
ICD-10 Finland
Impacted cerumen
3.8
20.1
64
180
TDA10
NOMESCO Finland
Needle biopsy of auricle or external auditory canal
25.9
18.3
25
10
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.8
18.0
102
407
J01DA01
ATC
[U] cefalexin
2.0
16.4
445
3299
H60.1
ICD-10 Finland
Cellulitis of external ear
13.2
16.3
28
22
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
4.8
16.1
37
81
L57.0
ICD-10 Finland
Actinic keratosis
2.4
15.4
117
536
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
12.2
15.2
27
23
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
4.6
15.1
36
81
H61.8
ICD-10 Finland
Other specified disorders of external ear
21.6
14.7
21
10
UDC00
NOMESCO Finland
Ear microscopy
3.0
14.7
70
253
4141
FHL
Myringoplasty (also for reasons other than inflammation)
30.8
13.9
18
6
H62.0*A46
ICD-10 Finland
Otitis externa in erysipelas
24.4
13.8
19
8
H60.3
ICD-10 Finland
Other infective otitis externa
6.2
13.5
23
38
H60.8
ICD-10 Finland
Other otitis externa
5.5
13.3
26
49
XQ848
NOMESCO Finland
Dermatological photography
4.1
13.1
37
95
M94.1
ICD-10 Finland
Relapsing polychondritis
+∞
12.5
12
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
5.2
12.0
25
50
H29
ICPC
Ear symptom/complaint other
2.2
11.3
101
494
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
11.2
167
987
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.1
10.8
114
594
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
4.7
10.1
23
50
SPAT1301
SPAT
No procedures
1.7
10.0
228
1526
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.9
9.9
161
973
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
9.7
206
1350
S02CA02
ATC
flumetasone and antiinfectives; otic
2.7
9.7
51
195
SPAT1254
SPAT
Administration of medicine
2.0
9.5
119
659
A46
ICD-10 Finland
Erysipelas
2.0
9.4
122
685
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.8
9.2
151
913
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
13.9
9.2
15
11
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
9.2
62
268
SPAT1153
SPAT
Removal of sutures
1.7
9.1
229
1566
ZXC50
NOMESCO Finland
Cryotherapy
3.4
9.0
33
102
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
9.0
215
1452
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
8.8
210
1415
J01MA02
ATC
ciprofloxacin; systemic
1.6
8.8
271
1952
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
8.8
235
1633
H01
ICPC
Ear pain/earache
2.2
8.7
75
361
J01FF01
ATC
clindamycin; systemic
1.7
8.6
188
1237
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
3.3
8.5
32
101
SPAT1263
SPAT
Sampling
1.6
8.3
283
2083
H70
ICPC
Otitis externa
4.8
8.2
18
38
E0000UV, ,
ATC
1.6
8.1
278
2045
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
7.9
93
504
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
7.8
83
433
H62.0
ICD-10 Finland
Otitis externa in bacterial diseases classified elsewhere
45.5
7.7
9
*
J01DB01
ATC
cefalexin; oral
1.7
7.7
538
4675
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
7.7
121
721
H92.0
ICD-10 Finland
Otalgia
2.6
7.7
44
176
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.0
7.6
93
510
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
7.5
205
1421
E000001, ,
ATC
1.8
7.4
129
790
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.2
7.4
62
294
H61.1
ICD-10 Finland
Noninfective disorders of pinna
81.0
7.4
8
*
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
7.3
91
501
K59.09
ICD-10 Finland
Constipation, unspecified
2.3
7.3
58
269
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.5
7.3
45
186
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.5
7.3
25
74
WX704
NOMESCO Finland
Intubation
2.3
7.3
57
263
N06AA09
ATC
amitriptyline; systemic
2.1
7.2
70
353
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
7.1
96
543
SPAT1310
SPAT
Counselling related to known health issue
1.6
6.9
209
1480
XQ845
NOMESCO Finland
Dermatoscopy
3.6
6.9
22
62
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
14.0
6.9
11
8
S18
ICPC
Laceration/cut
1.5
6.8
327
2568
N03AX16
ATC
[U] pregabalin
1.7
6.8
156
1031
J01CA04
ATC
amoxicillin; systemic
1.6
6.8
514
4464
H60
ICD-10 Finland
Otitis externa
2.8
6.8
34
127
H60.0
ICD-10 Finland
Abscess of external ear
40.5
6.8
8
*
N05AX12
ATC
aripiprazole; systemic
3.3
6.8
25
78
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
6.7
155
1025
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
6.7
334
2640
C07AB07
ATC
bisoprolol; oral
1.5
6.6
353
2827
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.5
6.6
22
64
J02AC01
ATC
fluconazole; systemic
1.6
6.6
228
1664
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.2
6.6
58
282
R50.9
ICD-10 Finland
Fever, unspecified
1.8
6.5
105
629
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.4
6.5
23
70
A04
ICPC
Weakness/tiredness general
1.8
6.5
112
685
A06AD11
ATC
lactulose; oral
1.7
6.4
118
733
A07AA02
ATC
nystatin; oral
2.3
6.4
49
224
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
2.6
6.3
37
150
SPAT1081
SPAT
Cardiorespiratory global assessment
2.3
6.3
46
207
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
26.9
6.2
8
*
H61.9
ICD-10 Finland
Disorder of external ear, unspecified
26.9
6.2
8
*
C03CA01
ATC
furosemide; systemic
1.5
6.1
246
1848
SPAT1260
SPAT
Consultation of another employee
1.7
6.1
118
743
SPAT1285
SPAT
Provision of consultation response
2.4
6.1
39
165
D07AC01
ATC
betamethasone; topical
1.5
6.0
235
1752
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
6.0
84
480
N05CD07
ATC
temazepam; oral
1.8
6.0
95
565
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
136
777
1.94
9.96
6.9
7.2
1.82
1.01
mmol/l
1.30
115
640
137
794
1.91
9.59
7.2
7.0
5.16
5.09
kpa
0.23
131
765
136
794
1.89
9.29
7.2
7.0
11.70
11.88
kpa
0.15
130
768
271
1943
1.66
9.00
2.3
2.1
162.70
274.82
u/l
1.38
258
1836
349
2668
1.64
8.99
3.2
3.0
138.76
137.97
ug/l
0.02
313
2468
175
1138
1.73
8.27
2.5
1.9
—
—
—
0
0
207
1412
1.67
8.18
5.8
4.6
1.02
1.02
kg/l
0.26
146
968
395
3170
1.59
7.90
9.1
7.1
1.21
1.21
mmol/l
0.89
350
2735
433
3557
1.61
7.80
6.8
5.0
6.78
6.74
mmol/l
0.15
412
3392
260
1900
1.60
7.70
1.8
1.8
20.75
20.60
nmol/l
0.05
229
1599
354
2793
1.56
7.44
6.9
5.0
34.65
35.17
g/l
0.90
335
2615
88
478
1.97
7.38
1.7
1.7
—
—
—
0
0
396
3247
1.53
6.69
7.8
6.6
11.18
11.60
umol/l
0.31
381
3099
385
3139
1.53
6.67
5.5
4.3
0.00
5.17
estimate
0.80
74
678
385
3165
1.50
6.23
5.4
4.3
0.00
0.49
estimate
0.52
72
626
275
2114
1.51
6.14
3.8
3.2
1488.04
1577.82
ng/l
0.15
245
1833
355
2885
1.49
5.98
8.0
6.3
1.20
1.21
mmol/l
2.21
334
2651
345
2794
1.48
5.88
2.5
2.2
96.30
94.54
pmol/l
0.25
196
1467
403
3369
1.49
5.83
12.5
9.8
4.51
4.16
e9/l
1.64
367
2932
30
114
2.71
5.81
5.4
5.9
1794.57
146.87
iu/ml
—
7
15
125
811
1.66
5.79
2.4
1.9
—
—
—
0
0
131
861
1.65
5.77
2.4
1.8
—
—
—
0
0
251
1915
1.50
5.71
3.6
2.5
59.24
64.03
u/l
0.46
240
1784
330
2676
1.46
5.43
2.7
2.5
77.46
78.68
nmol/l
0.31
303
2395
509
4495
1.54
5.42
10.9
8.4
81.33
80.03
u/l
0.26
487
4256
223
1678
1.49
5.37
2.7
2.3
2.98
3.03
mg/l
0.14
198
1444
372
3105
1.44
5.14
5.4
4.3
0.00
0.00
estimate
-0.00
71
654
452
3914
1.47
5.13
6.7
5.1
1068.20
2787.84
e6/l
—
5
74
163
1159
1.54
5.10
2.0
1.8
1263.59
1189.96
nmol/l
0.47
133
868
94
596
1.67
4.73
1.9
2.0
389.78
383.69
nmol/l
0.10
85
554
30
127
2.43
4.71
1.6
1.4
—
—
—
0
0
33
147
2.31
4.64
1.5
1.4
—
—
—
0
0
354
2964
1.41
4.60
24.9
16.5
1.32
1.29
inr
0.40
314
2475
292
2367
1.41
4.56
5.5
4.3
0.09
0.05
estimate
0.28
58
553
26
106
2.51
4.43
1.4
1.4
—
—
—
0
0
481
4271
1.44
4.35
6.3
4.6
14.24
13.21
mm/h
0.75
453
3971
114
774
1.57
4.34
5.7
4.4
243.77
260.06
u/l
0.63
107
733
36
174
2.13
4.19
2.5
1.6
—
—
—
0
0
21
79
2.71
4.19
1.6
1.4
—
—
—
0
0
21
80
2.68
4.10
1.6
1.4
—
—
—
0
0
21
80
2.68
4.10
1.6
1.4
—
—
—
0
0
46
247
1.93
4.04
2.4
2.3
43.98
39.39
u/l
0.72
41
221
202
1562
1.42
4.02
3.5
2.8
332.31
346.67
umol/l
1.25
179
1356
84
544
1.62
3.90
2.9
2.5
5.78
6.23
ug/l
0.13
76
487
222
1771
1.38
3.62
5.6
4.4
0.00
0.01
estimate
0.96
65
600
13
35
3.77
3.61
1.3
1.3
—
—
—
0
0
54
317
1.76
3.60
3.0
3.2
4.28
4.46
pmol/l
0.55
48
273
43
238
1.86
3.48
5.7
3.9
1.23
1.40
mmol/l
0.74
43
232
292
2446
1.34
3.44
5.4
4.1
45.59
72.51
ng/l
0.48
222
1872
70
448
1.63
3.42
2.6
2.3
13.02
13.39
nmol/l
0.15
58
401
43
242
1.83
3.31
2.3
2.7
0.65
1.18
g/l
0.71
37
205
157
1202
1.40
3.24
6.1
4.3
87.56
316.67
ng/l
1.96
136
999
321
2746
1.32
3.20
3.2
2.8
—
—
estimate
—
0
0
130
966
1.43
3.17
1.3
1.3
6.37
11.73
u/ml
0.78
39
351
12
35
3.47
3.12
1.3
1.3
—
—
—
0
0
232
1903
1.33
3.07
4.2
3.2
36.90
33.02
u/l
0.36
218
1797
477
4332
1.35
3.06
5.4
4.3
15.04
14.98
pmol/l
0.22
438
3942
41
235
1.79
3.00
5.7
3.5
44.73
79.46
mg/l
0.70
36
197
10
26
3.89
2.99
2.2
3.7
1196.70
895.50
u/ml
—
10
26
583
5480
1.47
2.98
27.2
17.7
26.47
25.55
mg/l
0.26
518
4590
145
1117
1.38
2.86
2.8
2.5
11.65
12.61
umol/l
0.99
134
1040
25
123
2.07
2.85
1.4
1.4
—
—
—
0
0
18
77
2.37
2.84
1.6
1.4
—
—
—
0
0
18
77
2.37
2.84
1.6
1.4
—
—
—
0
0
18
78
2.34
2.76
1.6
1.4
—
—
—
0
0
40
235
1.75
2.71
5.8
3.5
37.51
44.09
mg/l
0.26
35
199
10
29
3.48
2.70
1.3
1.3
—
—
—
0
0
10
29
3.48
2.70
1.3
1.3
—
—
—
0
0
40
236
1.74
2.68
2.2
1.9
—
—
—
0
0
550
5142
1.38
2.66
6.6
5.4
2.04
1.97
mu/l
0.30
512
4703
56
362
1.60
2.66
4.9
3.6
42.63
48.20
%
0.93
56
353
16
67
2.42
2.65
3.4
2.0
—
—
—
0
0
250
2109
1.29
2.63
3.8
3.4
7.07
7.27
mmol/l
0.37
227
1776
166
1323
1.34
2.62
2.1
1.8
405.84
25115014.93
pmol/l
1.18
139
1091
405
3634
1.29
2.61
4.3
3.3
57.58
50.78
u/l
0.76
385
3405
15
62
2.45
2.55
3.5
2.1
—
—
—
0
0
31
172
1.84
2.54
2.3
1.5
—
—
—
0
0
110
826
1.40
2.52
5.4
5.4
1.04
1.03
mmol/l
0.11
105
756
596
5662
1.45
2.51
30.6
21.6
4.00
3.99
mmol/l
0.23
590
5545
64
433
1.53
2.51
8.5
8.6
93.52
94.02
%
0.32
64
428
135
1052
1.35
2.47
1.4
1.3
35.95
37.41
iu/ml
0.05
46
331
51
329
1.60
2.46
1.1
1.2
200.55
130.03
u/ml
0.48
21
122
595
5655
1.45
2.46
30.6
21.4
139.56
139.63
mmol/l
0.27
589
5548
80
570
1.46
2.45
1.4
1.6
1.56
1.51
%
0.17
65
478
133
1036
1.35
2.44
3.2
3.2
0.82
0.82
mmol/l
0.07
127
974
39
237
1.69
2.37
2.7
3.0
—
—
—
0
0
36
214
1.72
2.37
1.7
1.8
—
—
—
0
0
90
661
1.42
2.35
4.0
3.4
2.13
1.85
mmol/l
0.29
82
560
92
680
1.41
2.32
3.2
2.5
10.03
7.94
umol/l
0.41
82
604
132
1036
1.34
2.30
2.7
2.5
2.46
2.28
g/l
3.25
122
966
96
716
1.40
2.30
10.7
8.1
—
—
—
0
0
201
1675
1.28
2.27
4.9
3.7
0.00
0.06
estimate
0.63
54
531
92
684
1.40
2.25
3.9
3.4
5.88
5.80
kpa
0.27
92
664
165
1345
1.30
2.20
1.8
1.7
1.35
1.41
mg/l
0.08
139
1059
8
24
3.36
2.18
4.0
2.2
40.50
41.83
g/l
—
8
24
254
2187
1.26
2.18
3.6
3.6
2.33
2.35
mmol/l
2.04
239
1963
80
584
1.42
2.17
3.6
2.8
4.12
4.40
kpa
0.70
80
563
11
42
2.65
2.15
5.3
1.9
—
—
—
0
0
50
338
1.52
2.01
1.5
1.5
—
—
—
0
0
122
969
1.32
1.96
2.7
2.5
19.24
22.10
%
1.82
111
908
15
71
2.14
1.93
1.8
1.2
—
—
—
0
0
38
245
1.58
1.88
1.1
1.1
—
—
—
0
0
598
5740
1.37
1.84
16.9
12.8
24.71
25.19
u/l
0.33
585
5571
240
2091
1.23
1.79
4.6
4.2
5.25
8.49
mg/mmol
1.18
158
1306
265
2335
1.22
1.76
2.1
1.9
1.41
1.33
mmol/l
0.70
228
1932
16
81
2.00
1.76
1.3
1.5
—
—
—
0
0
154
1280
1.26
1.75
1.4
1.3
0.98
1.40
u/ml
0.64
38
338
8
31
2.60
1.66
1.9
2.2
—
—
—
0
0
33
213
1.58
1.65
6.0
3.4
2.51
2.89
ratio
0.12
21
129
5
14
3.59
1.62
1.2
1.0
—
—
—
0
0
45
313
1.47
1.61
1.7
1.9
1.46
1.59
g/l
0.32
39
285
16
84
1.93
1.61
4.4
2.0
10.56
10.68
mmol/l
0.06
16
84
27
169
1.62
1.54
4.0
3.4
0.86
0.85
nmol/l
0.03
21
142
5
15
3.35
1.52
1.2
1.3
—
—
—
0
0
44
310
1.45
1.49
4.8
3.2
25.62
25.11
mmol/l
0.50
44
301
16
87
1.86
1.47
1.3
1.4
62185.73
1560.97
e6/l
0.46
11
60
334
3048
1.19
1.46
2.9
2.8
—
—
—
0
0
17
95
1.81
1.44
1.2
1.2
171.78
285.75
u/ml
—
9
49
34
230
1.50
1.42
1.4
1.3
—
—
—
0
0
23
142
1.64
1.40
2.0
1.7
5.57
46.63
iu/l
—
10
55
607
5880
1.33
1.39
39.6
27.1
4.34
4.43
e12/l
3.56
600
5746
22
135
1.65
1.37
1.4
1.1
1.54
1.54
g/l
0.03
22
135
19
112
1.72
1.36
3.0
1.4
0.80
0.88
nmol/l
0.16
13
95
5
17
2.95
1.36
1.2
1.1
—
—
—
0
0
19
113
1.70
1.33
2.9
1.7
—
—
—
0
0
28
185
1.54
1.31
1.5
1.3
—
—
—
0
0
27
178
1.54
1.28
1.3
1.4
310.59
286.16
ug/g
0.27
17
103
8
35
2.30
1.27
4.4
2.1
248.50
238.80
e6/l
—
8
30
6
25
2.41
1.24
1.0
1.0
—
—
—
0
0
75
598
1.29
1.21
6.0
6.6
1.24
1.35
mmol/l
0.78
75
587
6
26
2.32
1.19
1.5
1.4
—
—
—
0
0
6
26
2.32
1.19
1.2
2.0
57.35
58.75
ug/l
—
6
26
48
361
1.35
1.17
4.5
3.5
2.12
1.81
mmol/l
0.18
36
264
176
1546
1.19
1.16
5.0
4.8
21.77
21.65
%
0.04
95
787
11
58
1.91
1.12
1.6
1.4
—
—
—
0
0
10
51
1.98
1.11
1.0
1.3
—
—
—
0
0
22
144
1.55
1.10
1.4
1.2
0.88
0.90
g/l
0.17
22
144
14
81
1.74
1.09
1.2
1.3
0.53
22.97
nmol/l
0.50
14
76
544
5239
1.20
1.08
8.3
6.9
40.44
39.74
mmol/mol
0.93
519
4886
14
82
1.72
1.06
1.0
1.0
—
—
—
0
0
5
22
2.28
1.03
1.0
1.1
—
—
—
0
0
7
34
2.07
1.03
2.0
1.3
131.14
166.48
pmol/l
—
7
34
94
787
1.23
1.03
1.6
1.5
—
—
—
0
0
9
47
1.93
1.02
1.0
1.7
—
371.25
—
0
8
60
477
1.28
1.02
1.6
1.4
—
—
—
0
0
5
23
2.18
0.98
2.6
1.9
83.00
104.00
%
—
5
23
567
5495
1.20
0.97
6.7
6.1
2.53
2.63
mmol/l
2.04
539
5049
49
385
1.29
0.92
2.8
3.3
24.53
24.13
mmol/l
0.34
49
380
6
28
2.15
0.91
4.8
5.3
—
—
—
0
0
553
5368
1.17
0.82
5.5
5.2
1.45
1.47
mmol/l
0.52
523
4924
6
32
1.88
0.82
2.5
2.4
—
—
—
0
0
67
558
1.22
0.80
2.8
2.4
35.05
33.72
u/l
0.14
62
465
20
139
1.45
0.80
1.9
1.5
—
—
—
0
0
11
66
1.68
0.79
3.5
1.6
—
—
—
0
0
11
66
1.68
0.79
3.5
1.6
—
—
—
0
0
11
66
1.68
0.79
3.5
1.6
—
—
—
0
0
82
698
1.20
0.79
1.5
1.4
—
—
—
0
0
9
55
1.64
0.73
1.4
1.4
19.10
25.72
u/l
—
9
47
81
695
1.19
0.72
3.5
4.4
35.61
29.66
ug/l
0.09
68
591
554
5392
1.15
0.72
5.9
5.3
4.44
4.55
mmol/l
1.77
526
4978
9
56
1.62
0.72
1.7
1.1
0.91
1.76
nmol/l
—
9
50
7
40
1.76
0.71
2.1
2.2
13.93
13.27
%
—
7
40
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
27
1.86
0.68
1.4
1.2
—
—
—
0
0
60
505
1.21
0.67
3.8
3.9
99.20
87.30
ng/l
0.47
51
438
5
28
1.79
0.66
1.4
1.1
—
—
—
0
0
21
154
1.38
0.65
2.1
2.4
13.24
73.55
ug/min
2.39
11
86
21
155
1.37
0.63
1.5
1.4
—
—
—
0
0
549
5355
1.14
0.62
6.1
5.5
6.02
6.00
mmol/l
0.14
515
4873
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
23
174
1.33
0.60
2.7
1.9
2.62
4.04
mg/l
0.55
16
131
43
354
1.23
0.60
1.4
1.2
270.14
297.98
u/ml
0.06
38
326
40
485
0.81
0.59
2.6
2.9
57.50
63.46
ml/min/173m2
0.59
20
202
527
5137
1.12
0.57
4.7
4.4
1.37
1.27
mmol/l
1.60
493
4670
6
36
1.67
0.57
1.2
1.7
79.82
83.12
ng/l
—
6
36
27
212
1.29
0.56
1.5
1.5
0.45
0.36
mg/l
—
10
92
159
1464
1.11
0.55
2.6
2.4
—
—
—
0
0
6
38
1.58
0.54
3.3
2.7
2.08
0.87
%
—
6
38
541
5286
1.12
0.54
21.0
17.4
76.06
76.77
ml/min/173m2
0.34
509
4942
23
178
1.30
0.53
1.7
1.6
—
—
—
0
0
17
128
1.34
0.48
1.5
1.3
—
—
—
0
0
17
128
1.34
0.48
1.5
1.3
—
—
—
0
0
49
423
1.17
0.45
1.9
1.7
—
—
—
0
0
5
32
1.57
0.42
1.0
1.2
—
—
—
0
0
22
176
1.26
0.42
2.0
1.5
—
—
—
0
0
203
1917
1.08
0.42
5.7
5.7
2.94
2.78
ug/l
0.13
178
1714
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
21
168
1.26
0.40
1.6
1.3
—
—
—
0
0
8
60
1.34
0.40
2.9
2.4
636.63
942.08
mg
—
8
60
5
35
1.43
0.39
5.4
1.9
—
—
—
0
0
5
35
1.43
0.39
5.4
1.9
—
—
—
0
0
5
35
1.43
0.39
5.4
1.9
—
—
—
0
0
5
35
1.43
0.39
1.2
5.2
—
58.17
—
0
6
5
35
1.43
0.39
1.6
1.5
—
—
—
0
0
5
35
1.43
0.39
1.6
1.5
—
—
—
0
0
5
35
1.43
0.39
5.4
1.9
—
—
—
0
0
20
160
1.26
0.39
1.5
1.6
28474.73
15781.05
e6/l
0.31
15
118
5
79
0.63
0.35
1.0
1.1
—
—
—
0
0
143
1343
1.08
0.34
3.4
3.1
2.46
2.46
mmol/l
0.17
127
1204
6
44
1.37
0.34
1.2
1.3
—
—
—
0
0
6
87
0.69
0.33
1.3
1.1
—
—
—
0
0
17
137
1.25
0.32
1.2
1.4
—
—
—
0
0
13
101
1.29
0.32
1.5
1.7
—
—
—
0
0
8
62
1.29
0.28
1.9
2.4
—
—
—
0
0
20
169
1.19
0.26
1.5
1.9
—
—
—
0
0
16
133
1.21
0.24
1.3
1.5
—
—
—
0
0
15
180
0.83
0.24
1.0
1.2
—
—
—
0
0
15
180
0.83
0.24
1.0
1.2
—
—
—
0
0
149
1422
1.06
0.24
3.4
2.8
6.59
5.55
e6/l
0.33
135
1291
43
390
1.11
0.23
2.6
1.9
—
—
—
0
0
5
38
1.32
0.23
1.0
1.3
—
—
—
0
0
5
39
1.28
0.23
3.2
2.6
16.60
40.70
mg/l
—
5
30
5
39
1.28
0.23
1.0
1.3
—
—
—
0
0
21
181
1.17
0.22
1.8
1.7
—
—
—
0
0
5
40
1.25
0.22
1.6
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
14
117
1.20
0.20
1.5
1.3
2.11
12.06
e6/l
—
9
83
39
355
1.10
0.20
2.7
1.8
—
—
—
0
0
6
50
1.20
0.19
1.3
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
213
1.13
0.18
2.9
2.5
0.36
0.35
iu/ml
0.07
15
121
7
58
1.21
0.18
1.4
1.3
—
—
—
0
0
7
59
1.19
0.18
1.4
1.1
—
—
—
0
0
24
268
0.89
0.17
1.1
1.3
—
—
—
0
0
8
69
1.16
0.16
4.0
4.2
—
—
—
0
0
41
441
0.93
0.15
2.5
2.0
3.23
3.51
ratio
0.86
34
351
22
198
1.11
0.14
1.8
2.0
—
—
—
0
0
10
118
0.85
0.14
5.0
2.8
7.35
8.63
pmol/l
—
10
118
118
1142
1.04
0.12
3.4
3.2
0.72
0.81
ug/l
0.67
83
751
5
46
1.09
0.09
1.4
1.4
—
—
—
0
0
5
47
1.06
0.09
2.2
1.1
95.00
101.04
pmol/l
—
5
47
5
60
0.83
0.08
1.2
1.2
—
—
—
0
0
5
63
0.79
0.08
4.0
3.4
13.40
77.65
u/ml
—
5
63
7
66
1.06
0.08
1.0
1.1
—
2.58
—
0
28
6
73
0.82
0.07
1.0
1.2
103.67
115.41
%
—
6
68
8
74
1.08
0.07
1.3
1.1
1.49
1.52
g/l
—
8
69
7
81
0.86
0.07
1.3
1.4
—
—
—
0
0
66
643
1.03
0.05
5.4
3.6
—
—
—
0
0
22
209
1.05
0.04
1.2
1.6
1.31
1.19
g/l
1.21
22
199
15
140
1.07
0.04
1.0
1.1
—
12.71
—
0
15
110
1084
1.02
0.04
3.0
3.1
1.13
1.07
e6/l
0.08
64
579
52
509
1.02
0.03
3.9
3.7
1.22
1.23
mmol/l
0.39
40
439
76
750
1.02
0.02
5.1
5.0
32.37
32.58
%
0.06
57
486
205
2038
1.01
0.02
4.0
3.5
18.76
95.69
e6/l
1.66
168
1564
99
1000
0.99
0.02
3.3
3.3
4.44
2.44
e6/l
0.66
53
498
176
1753
1.01
0.00
3.5
3.4
0.67
0.49
e6/l
0.37
140
1288
21
204
1.03
0.00
1.2
1.5
0.28
0.23
g/l
1.64
21
195
17
165
1.03
0.00
3.5
3.3
2.50
2.06
index
—
10
90
10
97
1.03
0.00
1.0
1.4
—
—
—
0
0
14
137
1.02
0.00
4.1
3.6
208.99
2026.07
u/ml
0.53
14
132
14
137
1.02
0.00
1.3
1.3
—
—
—
0
0
16
157
1.02
0.00
1.3
1.2
—
—
—
0
0
15
151
0.99
0.00
1.1
1.2
—
—
—
0
0
32
321
1.00
0.00
2.3
1.8
3.18
3.41
mmol/l
0.47
24
236
0
7
0.00
0.00
0.0
3.9
—
0.57
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
13.97
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.3
—
5.57
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.4
—
77.10
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
1.6
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
110.00
—
0
6
5
49
1.02
-0.00
1.6
1.1
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.1
87.00
98.30
%
—
5
53
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_PERCHRONDR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_PERCHRONDR | 1.613 [1.35, 1.93] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.2 |
During the follow-up period (1.1.1998 — 31.12.2019), 337 out of 1198 females with H8_PERCHRONDR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_PERCHRONDR | 1.223 [1.0, 1.49] | 0.046 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 924 males with H8_PERCHRONDR died.
Mortality risk
Mortality risk for people of age
years, who have H8_PERCHRONDR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.181% |
| 5 | 1.027% | 1.238% |
| 10 | 2.192% | 3.306% |
| 15 | 4.13% | 6.583% |
| 20 | 7.925% | 10.866% |
Relationships between endpoints
↥Index endpoint: H8_PERCHRONDR – Perichondritis of external ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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