Noise effects on inner ear

H8_NOISEINNER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H83.3
  • Hospital discharge: ICD-9 3881
  • Cause of death: ICD-10 H83.3
  • Cause of death: ICD-9 3881

2 out of 7 registries used, show all original rules.

1771

4. Check minimum number of events

None

1771

5. Include endpoints

None

1771

6. Filter based on genotype QC (FinnGen only)

1619

Control definitions (FinnGen only)

Control exclude
H8_INNER

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H83
Name in latin
Laesio auris internae e strepitu

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13487 861 12565
Only index persons 12716 844 11872
Unadjusted period prevalence (%)
Whole population 0.33 0.02 0.35
Only index persons 0.43 0.03 0.45
Median age at first event (years)
Whole population 53.71 51.05 53.80
Only index persons 52.85 51.01 52.98

-FinnGen-

Key figures

All Female Male
Number of individuals 1619 146 1473
Unadjusted period prevalence (%) 0.62 0.05 0.68
Median age at first event (years) 56.82 49.59 57.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1661
Matched controls
16610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H83.3
ICD-10 Finland
Noise effects on inner ear
9415.3
307.7
1591
40
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
9.0
307.7
869
1801
DFF00
NOMESCO Finland
Pure tone audiometry
6.6
231.0
454
898
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
7.3
199.8
331
545
Z01.1
ICD-10 Finland
Examination of ears and hearing
4.7
159.6
473
1306
DAX08
NOMESCO Finland
Fitting of hearing aid
6.6
154.6
278
493
DFF15
NOMESCO Finland
Speech audiometry
7.2
151.9
246
391
UDC00
NOMESCO Finland
Ear microscopy
5.9
143.6
290
574
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.5
129.4
231
404
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.7
107.8
217
424
H93.1
ICD-10 Finland
Tinnitus
5.1
107.1
248
549
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
6.6
82.6
140
230
Z57.0
ICD-10 Finland
Occupational exposure to noise
179.0
81.9
85
5
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
5.9
81.3
155
286
3881A
ICD-9 Finland
Other disorders of ear, Noise effects on inner ear
+∞
72.4
69
*
H02
ICPC
Hearing complaint
2.6
46.8
322
1404
SPAT1043
SPAT
Audiometry
2.9
41.7
216
811
N07CA01
ATC
betahistine; oral
3.6
41.5
147
439
W34
ICD-10 Finland
Discharge from other and unspecified firearms
78.9
41.1
46
6
W42
ICD-10 Finland
Exposure to noise
+∞
34.5
33
*
W3388, ,
ICD-10 Finland
+∞
33.4
32
*
H91.9
ICD-10 Finland
Hearing loss, unspecified
3.0
26.6
127
453
WX720
NOMESCO Finland
Own respiration
3.0
25.5
121
430
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
24.7
270
1408
WX704
NOMESCO Finland
Intubation
2.4
22.1
164
729
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
5.6
20.1
38
69
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.6
20.0
117
464
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
2.8
19.5
98
359
H29
ICPC
Ear symptom/complaint other
2.1
18.9
204
1053
R4135
NOMESCO Finland
Rehabilitation for hearing problems
4.2
18.7
49
118
DFX03
NOMESCO Finland
Review, maintenance and user education for hearing aid
6.7
17.0
27
41
H81.3
ICD-10 Finland
Other peripheral vertigo
6.3
16.8
28
45
M03BX02
ATC
tizanidine; oral
1.6
16.6
946
7646
R5140
NOMESCO Finland
Monitoring the use of the aid
1.9
16.5
237
1349
H03
ICPC
Tinnitus, ringing/buzzing ear
3.5
15.7
54
158
OAA80, ,
SPAT
1.9
15.4
223
1271
WX725
NOMESCO Finland
Noninvasive ventilation
2.3
14.7
114
515
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
1.8
14.5
240
1424
ZXE10
NOMESCO Finland
More than one and less than three hours
0.6
14.3
245
3853
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
14.1
419
2905
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
2.7
14.0
74
279
SPAT1263
SPAT
Sampling
1.5
14.0
587
4393
R5120
NOMESCO Finland
Preparation of an aid
2.9
13.8
64
225
WX702
NOMESCO Finland
Supraglottic ventilation device
2.3
13.7
101
447
ZXD10
NOMESCO Finland
Scheduled procedure
0.6
13.6
258
3959
XG410
NOMESCO Finland
Flow-volume spirometry
2.6
13.3
76
298
R42
ICD-10 Finland
Dizziness and giddiness
1.7
13.1
292
1881
N02BE01
ATC
paracetamol; systemic, rectal
1.7
12.8
1398
12642
H91.1
ICD-10 Finland
Presbycusis
2.2
12.8
110
520
WW200, ,
SPAT
1.5
12.3
457
3313
H81.0
ICD-10 Finland
Ménière disease
16.0
12.1
19
12
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
12.0
341
2327
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.0
11.8
126
646
L15
ICPC
Knee symptom/complaint
1.6
11.7
335
2290
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
11.4
359
2505
ZXE00
NOMESCO Finland
One hour or less
0.6
11.3
282
4081
M01AE01
ATC
ibuprofen; systemic, rectal
1.6
10.5
1415
12983
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.9
10.4
124
661
T70.0
ICD-10 Finland
Otitic barotrauma
18.9
10.3
15
8
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
10.1
586
4603
WX419
NOMESCO Finland
Other general anesthesy
4.8
10.0
22
46
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
10.0
285
1940
H91.8
ICD-10 Finland
Other specified hearing loss
4.2
9.9
26
63
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.8
9.7
150
870
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
9.6
375
2729
SFA10
NOMESCO Finland
One-surface restoration
1.4
9.5
809
6757
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
9.5
673
5455
M01AH05
ATC
etoricoxib; oral
1.4
9.3
929
7959
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
9.2
520
4048
R4110, ,
SPAT
1.7
9.2
182
1133
Z2221
NOMESCO Finland
Medical doctor
0.6
9.1
166
2608
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
9.1
648
5249
R01AD58
ATC
fluticasone, combinations; nasal
1.5
9.1
314
2228
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.5
9.0
293
2053
N03AX12
ATC
[U] gabapentin; oral
1.6
8.8
228
1516
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
2.5
8.8
54
221
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
8.5
1057
9309
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
8.4
946
8194
T15.0
ICD-10 Finland
Foreign body in cornea
2.0
8.4
89
456
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
8.3
260
1802
Z10.0
ICD-10 Finland
Occupational health examination
1.7
8.2
160
990
XCW10
NOMESCO Finland
Assessment of vision
3.4
8.1
28
83
J34.2
ICD-10 Finland
Deviated nasal septum
1.8
8.1
115
651
R05
ICPC
Cough
1.5
8.0
308
2226
SPAT1097
SPAT
Recording of ECG
1.6
8.0
204
1352
H81.2
ICD-10 Finland
Vestibular neuronitis
13.1
7.9
13
10
M02AA10
ATC
ketoprofen; topical
1.6
7.9
214
1439
L13
ICPC
Hip symptom/complaint
1.5
7.8
227
1548
DJD20
NOMESCO Finland
Plastic repair of septum of nose
2.0
7.8
84
434
J01DB01
ATC
cefalexin; oral
1.4
7.7
1264
11535
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
7.7
413
3173
S61.0
ICD-10 Finland
Open wound of finger(s) without damage to nail
1.6
7.6
175
1132
Z3231
NOMESCO Finland
Registered nurse
0.7
7.5
204
2938
R51.80
ICD-10 Finland
Headache
1.6
7.5
179
1167
M54.2
ICD-10 Finland
Cervicalgia
1.8
7.5
112
644
KMAK, ,
NOMESCO Finland
1.3
7.4
710
5961
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.7
7.4
128
767
Y89.1
ICD-10 Finland
Sequelae of war operations
13.4
7.4
12
9
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.6
7.4
163
1043
L01
ICPC
Neck symptom/complaint
1.6
7.3
188
1246
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.8
7.3
100
559
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
+∞
7.3
7
*
N40
ICD-10 Finland
Hyperplasia of prostate
1.4
7.2
529
4269
L08
ICPC
Shoulder symptom/complaint
1.4
7.1
322
2398
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.7
7.1
143
894
F76
ICPC
Foreign body in eye
3.8
7.1
21
56
H13
ICPC
Plugged feeling ear
1.4
7.1
298
2189
SPAT1301
SPAT
No procedures
1.4
7.0
401
3105
H01
ICPC
Ear pain/earache
1.7
7.0
132
810
M79.6
ICD-10 Finland
Pain in limb
1.3
7.0
572
4684
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
7.0
526
4255
G47.3
ICD-10 Finland
Sleep apnoea
1.4
7.0
418
3263
R01AD09
ATC
mometasone; nasal
1.3
6.9
574
4711
SFA30
NOMESCO Finland
Three-surface restoration
1.3
6.9
631
5251
M54.5
ICD-10 Finland
Low back pain
1.4
6.9
490
3929
N32.0
ICD-10 Finland
Bladder-neck obstruction
3.6
6.9
22
62
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
1.5
6.9
190
1282
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
6.7
641
5362
XQ848
NOMESCO Finland
Dermatological photography
2.3
6.7
48
212
G04CA02
ATC
tamsulosin; oral
1.3
6.6
551
4515
R06.0
ICD-10 Finland
Dyspnoea
1.4
6.6
371
2862
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
1.7
6.6
110
653
H90
ICD-10 Finland
Conductive and sensorineural hearing loss
7.8
6.6
14
18
G04CA52
ATC
tamsulosin and dutasteride; systemic
1.5
6.6
241
1722
XG405
NOMESCO Finland
Education on PEF monitoring
3.2
6.6
25
79
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.3
6.6
794
6850
SFA20
NOMESCO Finland
Two-surface restoration
1.3
6.5
844
7348
A98
ICPC
Health maint/preventive medicine
1.6
6.5
1530
14593
Z01.2
ICD-10 Finland
Dental examination
1.3
6.5
614
5124
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.7
6.4
105
621
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
1.5
6.4
180
1219
WZC00
NOMESCO Finland
Treatment plan or consultation
1.3
6.3
503
4092
XA402
NOMESCO Finland
ENMG
2.6
6.3
35
137
SPAT1041
SPAT
Comprehensive hearing test
3.2
6.3
24
76
RF313, ,
NOMESCO Finland
11.1
6.3
11
10
OAA65, ,
SPAT
1.5
6.3
227
1618
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.6
6.2
138
884
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.7
6.2
109
657
R03AC02
ATC
salbutamol; inhalant
1.3
6.2
711
6075
L12
ICPC
Hand/finger symptom/complaint
1.5
6.2
212
1495
SDA01
NOMESCO Finland
Periodontal treatment, very brief
1.4
6.2
330
2523
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
6.2
250
1822
M01AE02
ATC
naproxen; oral, rectal
1.3
6.1
745
6410
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
6.1
170
1148
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.1
256
1878
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.5
6.0
175
1192
R5140, ,
SPAT
3.2
6.0
23
73
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.6
6.0
149
980
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
2.3
6.0
44
196

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
129
514
2.64
21.87
6.1
7.0
1.25
1.37
mmol/l
0.66
121
449
100
370
2.81
19.56
6.7
8.1
104.44
105.67
mmol/l
1.22
94
326
100
370
2.81
19.56
6.7
8.1
11.49
11.46
mmol/l
0.02
94
326
438
6270
0.59
19.23
11.7
12.3
0.00
0.00
e9/l
0.99
372
5129
283
1646
1.87
18.54
5.6
4.9
31.87
30.60
%
1.17
206
1100
469
3217
1.64
16.93
3.9
3.6
1.02
1.02
kg/l
0.38
346
2144
138
710
2.03
12.83
6.0
6.2
0.99
0.85
%
5.20
131
666
146
774
1.97
12.48
5.7
5.9
1.88
1.69
%
0.92
139
727
1488
13726
1.81
12.22
5.5
5.1
1.30
1.32
mmol/l
0.74
1418
12873
272
1753
1.66
12.11
3.2
3.7
4.54
5.15
e9/l
0.56
233
1543
1507
13979
1.84
11.80
6.1
5.9
2.69
2.65
mmol/l
0.95
1437
13129
1491
13792
1.79
11.71
5.6
5.2
4.48
4.46
mmol/l
0.35
1423
13018
1441
13210
1.69
11.63
5.7
5.2
5.96
6.09
mmol/l
4.91
1364
12228
290
4184
0.63
11.45
3.5
3.5
0.31
0.39
e6/l
0.56
234
3133
1429
13165
1.61
10.19
4.6
4.4
1.35
1.37
mmol/l
0.38
1359
12264
587
4616
1.42
10.01
3.3
2.9
58.86
78.36
u/l
0.59
549
4337
1546
14562
1.89
9.99
12.1
12.5
30.09
30.43
u/l
0.30
1521
14202
165
989
1.74
9.54
2.9
2.4
6.03
6.01
ph
0.11
130
670
487
3743
1.43
9.30
3.2
2.7
0.00
0.04
0.74
12
75
199
1266
1.65
9.22
3.7
4.8
7.36
7.34
ph
0.69
158
959
1550
14664
1.85
9.10
22.2
22.4
85.34
86.38
umol/l
0.62
1540
14540
1425
13195
1.56
9.08
6.5
6.6
39.21
39.88
mmol/mol
2.62
1352
12462
1575
14982
1.99
9.02
25.2
25.6
90.96
91.19
fl
1.31
1568
14845
1575
14983
1.99
9.01
25.2
25.6
30.53
30.55
pg
0.18
1568
14845
1575
14984
1.99
8.99
25.3
25.7
4.65
4.62
e12/l
1.26
1556
14675
1575
14985
1.99
8.97
25.7
26.4
41.81
41.86
%
0.06
1566
14837
1575
14987
1.98
8.94
25.4
25.9
141.22
140.16
g/l
1.91
1568
14849
1575
14990
1.98
8.88
25.4
25.8
6.81
6.83
e9/l
0.08
1553
14680
1573
14975
1.95
8.70
25.4
25.8
232.24
236.79
e9/l
2.20
1556
14713
1045
9175
1.37
8.66
5.1
4.2
—
3.12
—
0
13
166
2572
0.61
8.55
2.8
3.3
2.41
2.44
mmol/l
3.85
154
2307
1455
13580
1.58
8.47
16.8
17.4
26.04
27.34
mg/l
0.70
1224
11284
1069
9444
1.37
8.36
5.7
5.3
4.45
2.51
ug/l
0.78
1009
8618
1076
9548
1.36
7.98
3.6
3.5
14.78
14.83
pmol/l
0.29
984
8749
1486
13973
1.60
7.96
20.2
20.8
139.88
139.68
mmol/l
2.86
1463
13750
51
1101
0.45
7.76
3.6
3.8
—
—
—
0
0
1488
14017
1.59
7.66
20.4
21.0
4.02
4.01
mmol/l
0.52
1462
13773
184
1202
1.60
7.64
3.3
3.0
186.26
207.52
ng/l
0.30
168
1100
84
1513
0.53
7.49
10.7
11.1
—
—
—
0
0
102
575
1.82
7.28
4.1
4.2
25.11
24.76
mmol/l
0.63
94
539
60
1188
0.49
7.18
12.5
12.0
94.58
93.97
%
0.64
60
1182
19
47
4.08
7.08
1.0
1.2
—
—
—
0
0
59
1157
0.49
6.87
12.7
12.2
0.59
0.63
%
0.41
59
1147
592
4902
1.32
6.62
4.4
3.7
—
0.71
—
0
17
63
1189
0.51
6.53
12.0
11.8
1.43
1.33
%
0.48
63
1181
188
2661
0.67
6.24
3.2
3.2
0.79
0.87
e6/l
0.18
123
1474
159
1054
1.56
6.21
9.2
12.7
16.87
16.28
%
1.78
153
1019
1099
9956
1.31
6.07
3.9
3.6
50.34
57.18
u/l
2.39
1060
9433
86
1448
0.57
6.05
2.5
2.8
36.19
73.45
u/l
0.59
70
1255
59
1079
0.53
5.54
4.2
4.6
1.21
1.22
mmol/l
0.36
51
948
160
1101
1.50
5.28
6.3
7.6
24.52
24.48
mmol/l
0.04
151
1059
1293
12063
1.32
5.26
4.6
4.4
1.91
1.94
mu/l
0.33
1187
11098
946
8486
1.27
5.24
4.5
4.3
3.43
534.52
e6/l
—
7
135
444
5338
0.77
5.15
4.2
4.1
66.83
94.01
e6/l
0.40
351
3964
637
5472
1.27
5.02
3.7
3.5
0.04
0.01
estimate
0.31
73
1289
472
3911
1.29
4.97
3.4
3.1
0.05
0.03
estimate
0.15
64
1178
661
5708
1.26
4.97
4.1
3.9
64.72
69.37
ng/l
0.07
481
4238
16
37
4.36
4.94
1.5
1.2
18.13
36.21
%
1.49
16
29
102
646
1.62
4.87
2.6
2.3
—
—
—
0
0
403
4877
0.77
4.85
3.5
3.6
25.74
92.20
e6/l
3.62
343
3803
19
491
0.38
4.57
5.4
4.9
7.39
7.41
ph
1.01
19
486
113
746
1.55
4.54
3.9
4.2
—
—
—
0
0
270
2096
1.34
4.52
1.4
1.3
49.63
29.18
iu/ml
0.67
78
615
812
7232
1.24
4.50
3.8
3.6
0.00
0.23
estimate
0.54
85
1383
808
7215
1.23
4.29
3.8
3.6
0.01
5.08
estimate
1.57
91
1530
43
798
0.53
4.29
3.8
4.6
36.86
36.91
°c
0.45
43
791
68
1108
0.60
4.25
10.3
10.6
23.61
24.73
mmol/l
1.33
68
1102
1163
10813
1.25
4.19
8.1
9.0
76.76
79.74
u/l
1.22
1120
10368
186
2464
0.72
4.15
3.5
3.4
0.93
0.78
e6/l
0.30
119
1276
176
1293
1.40
4.14
2.8
2.7
0.30
0.36
e6/l
0.30
170
1241
31
141
2.22
4.13
1.3
1.3
45129.17
57936.50
e6/l
0.17
18
103
155
1115
1.43
4.11
3.8
3.9
5.10
5.14
kpa
0.28
150
1071
61
1007
0.59
4.02
3.0
4.2
24.04
24.14
mmol/l
0.10
61
999
795
7120
1.22
4.00
3.8
3.5
0.00
0.00
estimate
-0.00
93
1520
205
2659
0.74
3.99
2.9
3.9
0.81
0.82
mmol/l
0.30
193
2543
777
6958
1.22
3.87
7.9
8.8
1.21
1.20
mmol/l
2.59
690
6040
150
1087
1.42
3.83
3.7
4.0
7.42
7.41
ph
0.57
130
914
205
1566
1.35
3.81
1.6
1.5
—
—
—
0
0
168
1243
1.39
3.81
2.1
2.1
0.00
0.01
estimate
0.50
26
278
84
547
1.56
3.64
2.0
1.9
—
—
—
0
0
124
1697
0.71
3.38
3.5
4.1
5.87
5.81
kpa
0.24
119
1653
243
1942
1.29
3.30
1.3
1.3
9.96
8.47
u/ml
0.12
84
763
13
340
0.38
3.29
4.5
5.6
8.58
8.57
kpa
0.01
13
334
13
338
0.38
3.25
4.5
5.5
5.02
5.03
kpa
0.03
13
333
13
337
0.38
3.23
4.5
5.5
1.61
2.50
mmol/l
—
7
226
696
6255
1.19
3.13
6.4
8.2
1.20
1.20
mmol/l
1.26
641
5831
266
3216
0.79
2.98
4.3
5.1
—
—
—
0
0
27
134
2.03
2.96
1.3
1.2
—
—
—
0
0
197
1560
1.30
2.88
2.3
2.8
98.75
159.36
ug/g
2.94
164
1291
665
5999
1.18
2.77
2.1
2.0
1.46
1.44
mmol/l
0.20
576
5049
516
4560
1.19
2.72
2.1
2.4
206.41
284.07
u/l
1.03
485
4339
96
687
1.42
2.70
1.9
2.1
0.00
1.17
estimate
0.51
18
217
684
6204
1.17
2.63
2.1
2.1
98.23
93.50
pmol/l
1.70
390
3617
48
298
1.63
2.61
1.1
1.1
6.84
3.60
eliau/ml
—
5
31
122
915
1.36
2.61
1.2
1.2
—
—
—
0
0
775
7106
1.17
2.59
14.3
16.8
1.30
1.29
inr
0.06
668
5965
127
1655
0.75
2.56
3.4
4.2
1.96
1.71
mmol/l
0.34
107
1431
370
3196
1.20
2.49
3.6
3.1
—
—
—
0
0
25
457
0.54
2.49
4.4
3.1
68.57
62.77
%
0.96
25
448
29
160
1.83
2.40
2.7
2.4
—
—
—
0
0
87
1186
0.72
2.36
1.4
1.4
—
—
—
0
0
138
1078
1.31
2.27
5.6
5.3
—
—
—
0
0
563
5079
1.16
2.24
4.0
3.6
31.83
39.40
u/l
1.53
522
4795
713
6559
1.15
2.16
3.1
3.0
—
—
estimate
—
0
0
22
398
0.55
2.15
4.5
4.2
—
—
—
0
0
447
3979
1.17
2.10
1.7
1.7
18.67
18.95
nmol/l
0.17
378
3418
630
5770
1.15
2.00
3.4
3.2
5.98
6.15
ph
4.55
401
3360
18
337
0.53
1.99
4.2
2.8
17.37
16.51
%
0.67
18
326
157
1272
1.26
1.97
1.5
1.4
—
—
—
0
0
7
21
3.34
1.96
1.7
1.3
—
—
—
0
0
560
5092
1.15
1.96
3.6
3.7
47.02
56.85
mg/l
0.46
369
3589
293
3370
0.84
1.95
2.6
2.8
2.67
3.32
e6/l
1.28
274
3100
145
1165
1.27
1.95
1.6
1.8
3.49
3.52
mmol/l
0.11
100
824
28
165
1.71
1.91
3.5
4.4
—
—
—
0
0
522
5733
0.87
1.91
3.1
3.2
0.71
0.76
ug/l
0.63
309
3635
27
159
1.71
1.86
1.7
1.5
76.64
59.75
%
1.86
22
105
592
5424
1.14
1.84
3.5
3.7
8.97
8.64
mmol/l
0.99
502
4647
924
8714
1.14
1.83
5.3
6.1
6.72
6.88
mmol/l
1.51
882
8367
5
12
4.18
1.82
1.0
1.3
—
—
—
0
0
296
2577
1.18
1.82
2.2
2.4
13.97
14.13
nmol/l
0.15
269
2354
342
3013
1.17
1.82
4.9
4.0
606.89
541.43
ng/l
0.08
273
2474
811
7602
1.13
1.74
6.5
7.5
12.15
12.77
umol/l
1.00
777
7311
9
194
0.46
1.73
1.2
1.5
—
—
—
0
0
32
202
1.60
1.72
1.2
1.2
—
—
—
0
0
116
923
1.28
1.71
2.8
2.4
27.05
19.50
au/ml
0.48
14
84
565
5186
1.14
1.68
4.0
4.4
6.19
9.68
mg/mmol
1.94
366
3545
248
2854
0.85
1.66
3.5
3.1
587.70
571.85
mosm/kgh2o
0.60
226
2518
717
6684
1.13
1.66
5.8
6.9
57.49
57.91
%
0.43
694
6437
730
6813
1.13
1.65
5.8
7.1
27.65
26.63
%
1.71
704
6505
193
1634
1.20
1.63
2.0
2.1
3.83
3.77
ratio
0.27
158
1314
267
2328
1.18
1.62
1.5
1.8
885.78
1145.17
nmol/l
6.93
215
1828
313
3528
0.86
1.62
2.7
2.6
—
—
—
0
0
11
50
2.21
1.57
5.0
7.1
4.97
5.58
kpa
0.84
11
50
5
15
3.34
1.52
1.2
1.2
2.13
2.10
umol/24h
—
5
15
711
6652
1.12
1.51
5.9
7.2
0.64
0.67
%
0.58
678
6293
174
1472
1.20
1.50
1.4
1.4
—
—
—
0
0
23
139
1.66
1.48
1.2
1.5
—
—
nmol/l
—
0
0
208
1790
1.19
1.48
1.3
1.4
528.75
381.78
titre
0.61
32
360
14
253
0.55
1.44
3.0
2.0
1.64
1.68
mmol/l
0.05
14
242
15
265
0.56
1.43
1.7
3.1
3.87
123.47
u/ml
1.15
15
259
605
5622
1.12
1.43
2.2
2.4
74.00
74.65
nmol/l
0.23
551
5115
158
1865
0.83
1.43
1.9
2.7
1.83
1.78
%
0.22
141
1685
710
6661
1.12
1.41
6.0
7.1
2.87
2.94
%
0.36
678
6304
32
213
1.51
1.41
1.3
1.1
30.15
14.66
au/ml
0.71
13
60
64
834
0.76
1.38
2.0
1.9
0.30
0.33
mg/l
0.19
34
451
147
1740
0.83
1.38
3.5
4.2
7.38
7.38
ph
0.65
97
1013
22
135
1.64
1.36
1.8
1.5
—
—
—
0
0
453
4156
1.12
1.33
2.6
3.1
359.17
369.53
umol/l
1.50
419
3741
25
378
0.66
1.29
1.1
1.1
—
—
—
0
0
6
134
0.45
1.28
4.0
2.2
831.50
644.22
ml
—
6
77
5
117
0.43
1.25
1.2
1.5
13.60
14.26
umol/l
—
5
112
492
4551
1.12
1.24
3.2
3.3
1140.50
1552.05
ng/l
1.77
411
3947
68
530
1.30
1.24
1.2
1.1
—
0.77
—
0
6
142
1667
0.84
1.23
6.8
8.6
9.98
10.54
mmol/l
0.50
137
1612
707
6668
1.10
1.23
6.0
7.2
9.29
9.25
%
0.14
675
6310
20
313
0.63
1.22
3.0
3.5
56.10
58.20
%
0.35
20
313
25
164
1.53
1.20
1.2
1.5
0.54
0.60
nmol/l
0.35
25
158
97
1175
0.81
1.18
1.5
1.6
—
—
—
0
0
11
198
0.55
1.16
3.1
2.0
10.66
11.14
%
0.17
11
198
1171
11349
1.11
1.13
19.5
21.1
13.53
13.64
%
2.34
1158
11214
411
4452
0.90
1.13
3.0
3.6
2.33
2.34
mmol/l
0.78
381
4061
8
40
2.00
1.12
2.9
2.7
50.88
91.37
ug/l
—
8
40
7
137
0.51
1.09
1.1
1.3
—
174.62
—
0
26
786
7483
1.10
1.09
5.4
7.0
0.22
0.21
e9/l
0.20
713
6543
27
186
1.46
1.06
1.1
1.2
—
—
—
0
0
777
7402
1.09
1.06
5.3
6.9
1.94
1.92
e9/l
0.09
710
6520
153
1757
0.86
1.04
1.8
1.8
—
—
—
0
0
11
60
1.84
1.03
1.5
1.5
41.80
40.42
g/l
0.45
11
60
163
1858
0.86
1.01
1.4
1.4
—
—
—
0
0
12
68
1.77
1.00
1.3
1.2
7.75
8.66
mm/h
0.12
12
68
202
2265
0.88
1.00
2.7
3.0
23.04
23.81
%
0.38
190
2143
23
156
1.48
0.98
1.2
1.5
0.87
1.30
promille
0.79
17
124
11
61
1.81
0.98
1.2
1.1
—
—
—
0
0
543
5104
1.09
0.98
2.3
2.2
—
—
—
0
0
27
377
0.71
0.97
1.2
1.3
—
—
—
0
0
759
7244
1.09
0.97
5.3
6.8
0.61
0.62
e9/l
1.13
687
6232
761
7267
1.09
0.95
5.3
6.8
0.04
0.04
e9/l
0.24
688
6258
0
32
0.00
0.95
0.0
3.9
—
3062.69
—
0
32
0
32
0.00
0.95
0.0
1.9
—
—
—
0
0
121
1403
0.85
0.95
2.0
2.4
6.11
8.76
ug/l
1.61
100
1294
68
552
1.24
0.95
2.5
3.7
350.17
409.47
mg/l
0.19
23
284
12
197
0.61
0.94
1.2
1.6
6.70
6.33
mmol/l
0.38
12
186
217
2406
0.89
0.91
2.0
1.9
—
—
—
0
0
17
255
0.66
0.90
3.2
3.7
3.55
4.34
e9/l
0.97
17
255
42
324
1.30
0.88
4.3
4.4
—
—
—
0
0
8
42
1.91
0.88
1.9
2.3
—
—
—
0
0
378
4061
0.91
0.88
3.9
5.1
7.40
7.40
ph
0.09
303
2955
15
95
1.58
0.87
2.3
2.4
7.90
7.19
mmol/l
—
8
63
196
1757
1.13
0.87
8.2
10.4
126.89
124.53
g/l
0.84
188
1716
88
743
1.19
0.85
1.9
2.0
2.07
1.95
ug/l
0.04
76
677
42
327
1.29
0.84
1.9
1.7
—
—
—
0
0
134
1523
0.87
0.83
2.2
2.4
0.19
0.21
g/l
2.31
127
1414
6
112
0.53
0.83
1.8
2.2
7.92
7.78
mmol/l
—
6
112
32
421
0.76
0.82
2.7
2.3
159.29
110.26
ug/min
0.15
21
254
6
32
1.88
0.82
1.0
1.2
138.67
139.57
mmol/l
—
6
23
52
418
1.25
0.81
1.6
1.5
278.96
255.55
ug/g
0.36
27
263
221
2429
0.90
0.81
2.6
2.9
2.31
2.25
g/l
0.86
207
2275
59
482
1.23
0.80
1.9
1.6
—
—
—
0
0
49
607
0.80
0.79
1.2
1.3
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
0.36
—
0
12
130
1474
0.87
0.79
2.0
2.7
69.94
69.64
e9/l
0.03
117
1095
0
26
0.00
0.78
0.0
6.1
—
8.66
—
0
26
183
1647
1.12
0.78
1.3
1.4
—
—
—
0
0
5
96
0.52
0.78
4.4
2.2
502.20
489.94
min
—
5
64
7
124
0.56
0.77
2.4
2.5
—
—
—
0
0
41
323
1.28
0.76
1.3
1.2
1.62
4.44
u/ml
—
5
21
50
404
1.24
0.76
1.1
1.1
—
—
—
0
0
175
1941
0.89
0.76
1.6
1.7
—
—
—
0
0
15
99
1.52
0.75
1.8
1.5
—
—
—
0
0
434
4603
0.92
0.75
3.1
2.7
—
—
—
0
0
22
158
1.40
0.74
1.3
1.1
—
—
—
0
0
5
24
2.09
0.74
1.0
1.0
—
—
—
0
0
92
1064
0.86
0.74
3.9
3.4
134.52
130.03
g/l
1.03
85
1038
46
370
1.25
0.73
2.8
1.7
0.74
0.89
nmol/l
1.48
40
327
113
1286
0.87
0.73
4.8
5.0
0.05
0.11
%
0.60
40
401
34
263
1.30
0.73
1.8
2.0
4.56
4.73
iu/l
0.02
15
107
81
944
0.85
0.72
1.5
2.0
1.07
1.35
g/l
0.86
73
881
11
68
1.62
0.71
1.0
1.1
1395.09
1348.62
miu/ml
0.12
11
68
43
532
0.80
0.71
3.3
3.0
1.63
1.61
mg/l
0.07
36
484
35
441
0.79
0.68
9.8
11.1
—
—
—
0
0
5
94
0.53
0.66
1.2
1.2
142.60
141.50
nmol/l
—
5
94
107
1212
0.87
0.66
2.4
2.9
10.19
10.81
g/l
0.73
98
1130
53
635
0.83
0.65
1.9
2.4
217.37
633.23
ug/l
2.50
53
611
31
394
0.78
0.65
2.6
3.3
2.38
1.97
index
0.10
24
223
108
957
1.14
0.62
4.0
5.2
99.43
106.77
ng/l
0.27
97
847
32
400
0.80
0.60
1.6
4.4
—
—
—
0
0
28
218
1.29
0.60
1.2
1.7
—
—
—
0
0
28
218
1.29
0.60
1.2
1.7
—
—
—
0
0
28
218
1.29
0.60
1.2
1.7
—
—
—
0
0
28
218
1.29
0.60
1.2
1.7
—
—
—
0
0
15
208
0.72
0.58
1.3
1.5
59731.11
63244.63
e6/l
—
9
126
7
112
0.62
0.58
1.1
1.3
—
—
—
0
0
25
193
1.30
0.57
1.0
1.1
1.92
2.19
u/ml
0.07
14
102
66
568
1.17
0.57
1.1
1.1
0.55
0.67
ratio
—
8
68
304
2856
1.08
0.57
1.7
1.8
161686222.51
31764150.15
pmol/l
1.07
261
2421
11
161
0.68
0.57
1.1
1.1
14.30
2.45
eliau/ml
—
5
71
51
603
0.84
0.57
2.7
4.0
216.73
3601.81
u/ml
1.03
44
519
36
294
1.23
0.54
1.5
1.2
—
—
—
0
0
6
38
1.58
0.54
1.2
1.0
—
—
—
0
0
49
576
0.85
0.52
1.7
2.0
23.52
21.23
s
0.41
42
520
10
66
1.52
0.52
4.0
2.5
—
—
—
0
0
6
40
1.50
0.51
1.2
1.1
—
—
—
0
0
22
170
1.30
0.51
1.2
1.4
259.47
311.10
pmol/l
0.31
17
147
314
2967
1.07
0.51
1.6
1.7
1.00
1.45
mg/l
2.89
251
2302
33
269
1.23
0.51
1.5
1.8
—
—
—
0
0
9
65
1.39
0.50
1.6
2.5
88.67
169.37
ng/l
—
9
65
16
118
1.36
0.50
1.4
1.6
89.13
87.93
umol/l
0.07
16
118
23
181
1.27
0.48
1.0
1.1
1.78
3.04
u/ml
0.49
13
83
220
2060
1.08
0.47
7.8
9.5
7.42
7.41
ph
2.46
154
1152
20
155
1.29
0.47
1.5
1.2
—
—
—
0
0
7
48
1.46
0.46
2.6
2.3
—
—
—
0
0
5
85
0.59
0.45
1.8
3.0
2030.00
1991.48
ml
—
5
77
92
828
1.12
0.45
1.3
1.3
—
—
—
0
0
19
242
0.78
0.44
3.3
4.5
10.21
10.61
pmol/l
0.05
19
242
219
2056
1.08
0.44
7.6
9.4
1.26
0.76
mmol/l
0.92
171
1699
201
1881
1.08
0.44
7.8
9.7
96.39
95.54
%
1.60
191
1820
220
2066
1.07
0.44
7.7
9.5
11.77
12.12
kpa
0.63
208
2001
220
2066
1.07
0.44
7.7
9.5
4.96
5.12
kpa
2.10
207
1997
16
121
1.33
0.44
1.3
1.2
—
—
—
0
0
7
51
1.37
0.44
1.0
1.1
—
14.80
—
0
5
18
230
0.78
0.43
1.2
1.2
1.83
4.04
u/ml
—
6
117
68
603
1.13
0.43
1.1
1.2
1.43
1.44
g/l
0.16
68
603
21
262
0.80
0.42
1.9
4.2
—
—
—
0
0
42
488
0.86
0.42
2.0
3.7
2.11
3.21
ratio
0.52
31
276
22
272
0.81
0.41
1.5
1.7
0.80
0.91
g/l
0.18
17
214
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
0.09
—
0
15
0
15
0.00
0.41
0.0
3.7
—
—
—
0
0
242
2558
0.94
0.41
1.5
1.6
2.44
2.72
g/l
1.21
150
1680
0
17
0.00
0.40
0.0
1.1
—
72.26
—
0
12
72
802
0.89
0.40
1.1
1.1
—
—
—
0
0
31
260
1.20
0.39
3.4
3.0
0.74
0.82
nmol/l
0.64
31
207
61
542
1.13
0.38
1.5
3.1
—
—
—
0
0
72
800
0.90
0.38
1.4
1.8
1.43
1.54
g/l
0.50
61
697
75
676
1.11
0.38
1.2
1.3
—
—
—
0
0
11
147
0.75
0.37
1.5
1.4
—
—
—
0
0
27
322
0.84
0.37
1.4
1.5
189.80
151.84
au/ml
—
5
95
9
70
1.29
0.36
1.2
1.2
—
—
—
0
0
39
449
0.87
0.36
1.4
1.3
40.00
101.49
titre
—
5
47
5
80
0.62
0.35
6.2
5.3
—
—
—
0
0
413
3988
1.05
0.34
3.4
3.7
0.00
0.00
estimate
0.96
78
1350
200
1893
1.06
0.34
1.2
1.3
—
—
—
0
0
32
372
0.86
0.34
3.1
3.0
89.98
89.28
%
0.22
32
361
165
1752
0.94
0.34
2.6
3.2
7.20
9.30
umol/l
1.35
150
1578
6
88
0.68
0.33
1.3
2.0
—
—
—
0
0
25
210
1.19
0.32
1.6
2.5
0.34
0.35
mmol/l
0.00
25
203
6
47
1.28
0.32
1.7
1.3
7.28
11.18
mmol/l
—
6
47
51
455
1.12
0.32
1.8
1.7
8.09
19.26
u/ml
2.38
18
109
81
743
1.09
0.31
3.3
2.8
—
—
—
0
0
405
4184
0.96
0.31
5.5
6.8
—
—
—
0
0
122
1303
0.93
0.30
5.2
5.1
0.22
0.09
%
0.61
45
376
127
1352
0.93
0.29
5.0
4.9
0.45
0.78
%
2.29
53
467
64
583
1.10
0.29
1.5
3.0
—
—
—
0
0
170
1790
0.94
0.28
1.8
1.8
—
—
—
0
0
66
604
1.10
0.28
1.2
1.2
—
—
—
0
0
37
327
1.13
0.28
1.4
1.2
3.37
3.82
mmol/l
2.17
30
308
562
5753
0.97
0.28
2.9
3.2
—
—
—
0
0
57
518
1.10
0.27
1.4
1.7
8.81
5.59
iu/ml
0.32
14
136
14
172
0.81
0.27
1.4
2.5
—
—
—
0
0
13
161
0.81
0.27
1.4
1.3
—
—
—
0
0
20
169
1.19
0.26
1.2
1.1
—
—
—
0
0
30
263
1.14
0.25
1.1
1.1
0.79
1.68
u/ml
0.81
21
144
46
508
0.90
0.25
1.5
1.4
5.62
6.10
u/l
0.23
38
408
25
287
0.87
0.24
1.1
1.1
—
—
—
0
0
122
1290
0.94
0.24
5.0
4.7
0.67
0.66
%
0.04
52
438
73
677
1.08
0.24
1.2
1.6
—
21.40
—
0
25
22
189
1.17
0.24
3.3
6.2
7.00
7.32
mmol/l
0.24
16
162
29
328
0.88
0.23
1.2
1.2
300.82
293.49
u/ml
0.05
17
205
64
591
1.09
0.23
1.5
2.9
—
—
—
0
0
64
592
1.08
0.23
1.5
2.6
—
—
—
0
0
353
3628
0.97
0.22
2.2
2.3
2.79
2.80
mg/l
0.02
316
3148
0
11
0.00
0.21
0.0
1.2
—
15.32
—
0
11
0
11
0.00
0.21
0.0
5.2
—
421.82
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
27.80
—
0
5
13
156
0.83
0.21
1.1
1.1
—
—
—
0
0
282
2735
1.04
0.21
1.3
1.3
1.76
1.69
u/ml
0.04
63
770
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
25
220
1.14
0.21
1.1
1.1
1.96
1.39
u/ml
0.12
13
110
19
219
0.87
0.20
1.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
34
307
1.11
0.20
3.3
3.6
6.74
7.64
mmol/l
1.53
34
298
50
461
1.09
0.20
1.6
3.1
—
—
—
0
0
601
5908
1.03
0.20
2.7
3.0
172.67
174.80
ug/l
0.05
563
5547
11
90
1.22
0.19
1.1
1.1
33.90
36.82
mmol/l
0.27
11
80
24
270
0.89
0.19
1.4
1.5
—
—
—
0
0
6
53
1.13
0.18
1.0
1.1
—
—
—
0
0
41
376
1.09
0.18
2.8
2.3
135.03
130.96
g/l
0.48
29
287
37
338
1.10
0.18
1.4
1.3
198.50
208.97
miu/ml
0.05
12
132
62
581
1.07
0.17
1.5
2.9
—
—
—
0
0
125
1302
0.96
0.16
2.1
2.9
66.40
66.27
g/l
0.07
114
1219
26
235
1.11
0.15
2.2
2.8
—
—
—
0
0
15
172
0.87
0.15
2.2
2.3
—
—
—
0
0
6
76
0.79
0.15
1.2
1.4
—
—
—
0
0
31
338
0.92
0.15
1.2
1.2
—
—
—
0
0
21
234
0.90
0.15
1.1
1.1
12.82
4.93
u/ml
0.56
15
128
29
265
1.10
0.14
1.1
1.1
74.50
85.63
iu/ml
—
8
55
94
900
1.05
0.14
1.7
1.9
—
—
—
0
0
19
212
0.90
0.14
1.9
2.5
2.82
1.60
g/24h
—
10
134
64
608
1.05
0.13
1.4
1.2
139.56
130.49
u/ml
0.05
25
197
11
94
1.17
0.13
1.0
1.0
—
—
—
0
0
252
2575
0.97
0.13
2.5
2.9
12.97
13.33
umol/l
0.37
242
2431
44
468
0.94
0.13
1.1
1.1
—
—
—
0
0
24
219
1.10
0.12
1.3
1.5
135.22
210.54
pmol/l
0.98
24
219
16
143
1.12
0.11
1.1
1.3
—
—
—
0
0
20
182
1.10
0.11
1.1
1.3
—
—
—
0
0
456
4503
1.02
0.10
4.3
4.8
—
—
—
0
0
100
1032
0.97
0.10
2.1
2.7
—
—
—
0
0
65
624
1.04
0.10
2.4
3.1
24.36
24.72
mmol/l
0.34
65
617
5
48
1.04
0.09
1.4
3.1
—
—
—
0
0
6
54
1.11
0.09
1.0
1.0
—
—
—
0
0
645
6398
1.01
0.08
5.5
6.0
36.06
35.51
g/l
1.68
616
6041
39
410
0.95
0.08
1.5
1.4
1.27
1.17
g/l
0.95
39
395
5
62
0.81
0.08
1.8
1.5
6.80
1.43
u/field
—
5
46
21
226
0.93
0.08
1.1
1.1
0.55
1.43
u/ml
0.74
11
92
5
63
0.79
0.08
1.2
1.1
—
331.49
—
0
16
5
63
0.79
0.08
1.0
1.0
—
—
—
0
0
5
64
0.78
0.08
1.0
1.0
—
—
—
0
0
7
64
1.09
0.08
1.3
1.1
—
—
—
0
0
62
598
1.04
0.08
1.3
1.3
—
—
—
0
0
247
2507
0.98
0.08
1.8
2.2
29.37
29.91
s
0.76
233
2453
6
70
0.86
0.07
1.2
1.2
130.17
175.44
iu/ml
—
6
70
6
73
0.82
0.07
1.2
2.2
4340.67
1173.18
u/ml
—
6
73
27
286
0.94
0.07
1.1
1.1
—
—
—
0
0
8
77
1.04
0.07
1.9
1.9
—
—
—
0
0
8
77
1.04
0.07
1.1
1.1
—
—
—
0
0
7
84
0.83
0.07
1.0
1.2
—
3.33
—
0
6
7
84
0.83
0.07
1.3
1.7
—
—
—
0
0
17
157
1.08
0.07
1.2
1.3
—
—
—
0
0
8
91
0.88
0.06
1.1
1.2
—
—
—
0
0
13
142
0.91
0.06
1.4
2.4
38.28
36.42
%
0.21
13
142
9
105
0.86
0.06
1.1
1.6
—
—
—
0
0
17
158
1.08
0.06
1.2
1.3
6.82
6.85
g/l
0.01
12
109
187
1844
1.02
0.06
1.4
1.6
—
—
—
0
0
17
182
0.93
0.05
1.1
1.2
—
—
—
0
0
38
395
0.96
0.05
1.5
1.4
0.25
0.25
g/l
0.08
38
378
19
202
0.94
0.05
1.1
1.6
—
—
—
0
0
25
238
1.05
0.05
1.4
2.6
—
—
—
0
0
49
476
1.03
0.04
1.2
1.2
—
—
—
0
0
410
4126
0.99
0.04
1.3
1.4
—
—
—
0
0
62
633
0.98
0.03
3.7
3.8
4.56
4.53
pmol/l
0.11
56
577
34
351
0.97
0.03
1.4
1.5
—
—
—
0
0
130
1285
1.01
0.03
2.8
2.3
421.99
371.32
nmol/l
0.98
122
1211
800
8019
1.00
0.02
7.9
10.5
4.18
4.28
e9/l
0.47
724
6966
32
329
0.97
0.02
1.5
1.3
427.96
1423.55
e6/l
0.80
25
253
16
168
0.95
0.02
1.1
1.0
0.04
0.37
u/ml
—
5
60
39
398
0.98
0.01
1.5
1.6
193.79
257.64
mu/l
2.69
39
374
150
1490
1.01
0.01
3.4
4.8
6.75
22.74
ug/l
1.82
113
1249
28
273
1.03
0.01
1.2
1.5
—
8.87
—
0
6
11
116
0.95
0.00
1.0
1.0
—
—
—
0
0
13
136
0.96
0.00
1.1
1.1
—
—
—
0
0
20
194
1.03
0.00
1.5
1.6
—
—
—
0
0
230
2307
1.00
0.00
2.1
2.3
—
—
—
0
0
30
294
1.02
0.00
3.6
3.4
37.84
30.19
mg/l
0.53
19
202
10
101
0.99
0.00
1.1
1.1
15.70
22.47
u/ml
—
5
37
32
322
0.99
0.00
1.5
1.3
27.88
38.17
e6/l
0.16
25
236
27
269
1.00
0.00
1.1
1.1
—
—
—
0
0
27
269
1.00
0.00
1.1
1.1
—
—
—
0
0
19
188
1.01
0.00
1.0
1.1
—
—
—
0
0
10
97
1.03
0.00
1.1
1.2
—
—
—
0
0
26
255
1.02
0.00
1.7
1.8
35.19
26.73
ug/l
0.24
26
249
0
6
0.00
0.00
0.0
1.2
—
184.67
—
0
6
0
6
0.00
0.00
0.0
1.0
—
618.43
—
0
6
5
53
0.94
0.00
1.4
1.6
26.96
9.16
nmol/l
—
5
45
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
9
91
0.99
0.00
1.0
1.2
98.00
105.59
pmol/l
—
9
91
5
50
1.00
0.00
1.0
1.4
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.3
0.00
0.11
estimate
—
5
57
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
-0.00
1.3
1.3
200.33
196.32
mmol/24h
—
6
64
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
1.4
3.0
—
—
—
0
0
6
64
0.94
-0.00
2.0
1.3
—
3.08
%
—
0
12
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
83
0.96
-0.00
2.3
1.9
—
—
—
0
0
6
69
0.87
-0.00
1.2
1.7
—
—
—
0
0
6
69
0.87
-0.00
2.2
1.2
6.70
9.48
ug/l
—
6
62
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
0.02
—
0
8
0
7
0.00
-0.00
0.0
8.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.08
—
0
5
0
7
0.00
-0.00
0.0
2.1
—
325.71
—
0
7
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.1
—
5.86
—
0
14
6
63
0.95
-0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
0.19
—
0
7
6
67
0.90
-0.00
1.2
1.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_NOISEINNER and mortality.

Females

Parameter HR [95% CI] p-value
H8_NOISEINNER 0.93 [0.69, 1.25] 0.628
Birth year 0.998 [0.99, 1.01] 0.64

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 717 females with H8_NOISEINNER died.

Males

Parameter HR [95% CI] p-value
H8_NOISEINNER 0.788 [0.72, 0.86] < 0.001
Birth year 0.99 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 1579 out of 10010 males with H8_NOISEINNER died.

Mortality risk

Mortality risk for people of age

years, who have H8_NOISEINNER.

N-year risk Females Males
1 0.078% 0.183%
5 0.599% 1.04%
10 1.384% 2.658%
15 2.62% 5.003%
20 4.996% 8.654%

Relationships between endpoints

Index endpoint: H8_NOISEINNER – Noise effects on inner ear

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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