otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
722 |
4. Check minimum number of eventsNone |
722 |
5. Include endpointsNone |
722 |
6. Filter based on genotype QC (FinnGen only) |
649 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H60
- Name in latin
- Otitis externa acuta non infectiosa
Similar endpoints
↥List of similar endpoints to
Acute otitis externa, noninfective
based on the number of shared cases.
Similar with more cases:
- Otitis externa
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4704 | 2439 | 2237 |
| Only index persons | 4262 | 2271 | 1991 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.06 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 45.42 | 45.65 | 45.04 |
| Only index persons | 44.12 | 44.57 | 43.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 649 | 384 | 265 |
| Unadjusted period prevalence (%) | 0.13 | 0.14 | 0.12 |
| Median age at first event (years) | 50.81 | 50.04 | 51.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 675
- Matched controls
- 6750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
+∞
307.7
675
15
H60.9
ICD-10 Finland
Otitis externa, unspecified
14.5
202.8
214
210
H60.3
ICD-10 Finland
Other infective otitis externa
32.7
188.9
126
47
H60.8
ICD-10 Finland
Other otitis externa
27.6
168.2
119
52
UDC00
NOMESCO Finland
Ear microscopy
9.2
117.2
164
228
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
14.0
86.2
83
67
S02CA02
ATC
flumetasone and antiinfectives; otic
8.4
84.1
121
171
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
13.4
69.5
68
56
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
14.4
60.3
56
42
H70
ICPC
Otitis externa
12.7
54.7
55
47
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
15.1
53.2
48
34
Z01.1
ICD-10 Finland
Examination of ears and hearing
4.1
51.8
179
549
H66.0
ICD-10 Finland
Acute suppurative otitis media
5.1
48.4
113
254
H65.3
ICD-10 Finland
Chronic mucoid otitis media
12.9
47.5
47
39
H60
ICD-10 Finland
Otitis externa
6.3
46.2
84
150
H61.2
ICD-10 Finland
Impacted cerumen
5.9
45.1
88
168
H04
ICPC
Ear discharge
7.6
40.5
60
86
H60.1
ICD-10 Finland
Cellulitis of external ear
16.2
39.4
34
22
H01
ICPC
Ear pain/earache
3.6
35.7
137
443
H65.0
ICD-10 Finland
Acute serous otitis media
10.8
34.5
38
37
H29
ICPC
Ear symptom/complaint other
3.2
27.9
129
464
DFF00
NOMESCO Finland
Pure tone audiometry
3.4
27.9
112
370
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.8
27.1
166
699
Z97.4
ICD-10 Finland
Presence of external hearing-aid
4.8
26.8
64
145
J01MA02
ATC
ciprofloxacin; systemic
2.4
25.9
313
1809
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
7.5
25.2
37
52
J01DA01
ATC
[U] cefalexin
2.4
24.6
474
3317
H66.9
ICD-10 Finland
Otitis media, unspecified
4.0
24.3
74
202
H92.0
ICD-10 Finland
Otalgia
3.9
22.3
69
190
H13
ICPC
Plugged feeling ear
2.5
21.9
170
797
H61.8
ICD-10 Finland
Other specified disorders of external ear
32.4
21.6
28
9
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
3.8
21.2
70
202
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
4.5
19.3
48
112
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.8
19.2
62
176
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.5
18.9
145
671
DAX08
NOMESCO Finland
Fitting of hearing aid
3.7
18.9
62
178
H71
ICD-10 Finland
Cholesteatoma of middle ear
17.1
18.0
28
17
J01DA09
ATC
[U] cefadroxil
2.1
16.4
206
1166
DC1AD
NOMESCO Finland
Temporalbone CT
17.2
16.2
25
15
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
24.0
15.2
21
9
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
15.5
15.0
24
16
H62.0*A46
ICD-10 Finland
Otitis externa in erysipelas
36.9
14.5
18
5
H65.2
ICD-10 Finland
Chronic serous otitis media
11.7
14.4
26
23
D07AC01
ATC
betamethasone; topical
1.9
13.8
265
1719
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
6.7
13.7
22
34
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
76.7
13.6
15
*
H60.0
ICD-10 Finland
Abscess of external ear
40.9
13.2
16
*
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
12.8
220
1369
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
12.8
104
490
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
12.6
144
778
H81
ICPC
Excessive ear wax
2.1
12.3
132
695
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
13.7
12.0
20
15
DFF15
NOMESCO Finland
Speech audiometry
3.1
11.4
49
167
TDA90
NOMESCO Finland
Removal wax from ear
9.4
11.1
22
24
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.4
11.0
78
345
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.8
11.0
198
1242
DCD00
NOMESCO Finland
Myringoplasty
12.2
10.9
19
16
J01DB01
ATC
cefalexin; oral
2.0
10.9
561
4776
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
10.6
67
280
H02AB04
ATC
methylprednisolone; systemic
2.1
10.5
108
557
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
26.5
9.8
13
5
H80.9
ICD-10 Finland
Otosclerosis, unspecified
10.2
9.6
18
18
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.8
9.5
29
79
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
9.5
286
2057
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
9.3
200
1311
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
9.3
142
841
J01MA12
ATC
levofloxacin; systemic
1.9
9.1
128
737
H74.1
ICD-10 Finland
Adhesive middle ear disease
15.8
9.1
14
9
J01FA10
ATC
azithromycin; systemic
1.6
8.9
388
3047
D07XC01
ATC
betamethasone; topical
2.1
8.9
88
447
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
8.9
149
908
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
8.8
251
1772
J02AC01
ATC
fluconazole; systemic
1.7
8.8
263
1881
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
8.7
159
993
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
7.8
8.7
19
25
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.0
8.6
97
517
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
8.5
196
1305
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
8.5
77
378
H60.4
ICD-10 Finland
Cholesteatoma of external ear
91.2
8.4
9
*
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
91.2
8.4
9
*
D07AB08
ATC
desonide; topical
2.1
8.4
82
414
S02CA06
ATC
dexamethasone and antiinfectives; otic
8.7
8.3
17
20
C03CA01
ATC
furosemide; systemic
1.7
8.3
190
1263
I25.2
ICD-10 Finland
Old myocardial infarction
2.6
8.3
48
193
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
8.2
160
1015
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
8.3
8.1
17
21
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
8.0
353
2755
R4135
NOMESCO Finland
Rehabilitation for hearing problems
4.4
8.0
20
47
H66
ICD-10 Finland
Suppurative and unspecified otitis media
4.0
7.9
22
56
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
7.8
84
440
K02.1
ICD-10 Finland
Caries of dentine
1.6
7.7
392
3148
R5120
NOMESCO Finland
Preparation of an aid
3.3
7.7
29
91
H70.1
ICD-10 Finland
Chronic mastoiditis
15.2
7.7
12
8
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.7
310
2361
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
3.3
7.6
28
87
J01CA04
ATC
amoxicillin; systemic
1.8
7.6
546
4770
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.7
7.5
180
1208
N02AX02
ATC
tramadol; systemic, rectal
1.6
7.5
288
2167
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
7.5
125
758
Z75.1
ICD-10 Finland
Person awaiting admission to adequate facility elsewhere
3.5
7.5
25
73
J01FF01
ATC
clindamycin; systemic
1.7
7.4
183
1235
R42
ICD-10 Finland
Dizziness and giddiness
1.7
7.4
153
986
D07CC01
ATC
betamethasone and antibiotics; topical
2.0
7.2
88
481
R06AE07
ATC
cetirizine; oral
1.6
7.2
282
2124
N03AX16
ATC
[U] pregabalin
1.7
7.2
152
985
XQ802
NOMESCO Finland
Epicutan test
2.8
7.1
35
129
G47.3
ICD-10 Finland
Sleep apnoea
1.7
7.1
156
1020
SPAT1310
SPAT
Counselling related to known health issue
1.6
7.1
207
1456
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.6
7.1
216
1535
R06.0
ICD-10 Finland
Dyspnoea
1.6
7.1
184
1258
SFA20
NOMESCO Finland
Two-surface restoration
1.5
7.0
387
3137
L04AA06
ATC
mycophenolic acid; systemic
4.3
7.0
18
43
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
6.4
7.0
17
27
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.9
6.9
86
474
SPAT1312
SPAT
General health counselling
1.6
6.9
200
1404
D07AD01
ATC
clobetasol; topical
1.8
6.8
113
682
E66.8
ICD-10 Finland
Other obesity
2.5
6.8
42
174
H02
ICPC
Hearing complaint
1.8
6.8
102
597
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
40.5
6.8
8
*
WZA90
NOMESCO Finland
Other medical or dental certificate
1.7
6.7
161
1075
D07BC01
ATC
betamethasone and antiseptics; topical
2.0
6.7
79
427
E000006, ,
ATC
2.3
6.7
51
233
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
6.7
89
502
M54.5
ICD-10 Finland
Low back pain
1.6
6.7
243
1794
H02AB06
ATC
prednisolone; systemic
1.5
6.7
310
2414
J01FA01
ATC
erythromycin; systemic
1.9
6.6
88
496
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
6.6
89
504
XQ800
NOMESCO Finland
Prick test
2.2
6.6
53
248
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
6.5
263
1985
J01AA02
ATC
doxycycline; systemic
1.6
6.5
505
4386
R01AD08
ATC
fluticasone; nasal
1.6
6.5
186
1299
H73.1
ICD-10 Finland
Chronic myringitis
70.5
6.4
7
*
C01DA14
ATC
isosorbide mononitrate; oral
1.8
6.3
94
548
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
6.3
474
4065
E0000UV, ,
ATC
1.5
6.3
270
2060
SFA10
NOMESCO Finland
One-surface restoration
1.5
6.2
361
2929
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.2
6.1
50
235
SFA30
NOMESCO Finland
Three-surface restoration
1.5
6.1
275
2114
E66.01
ICD-10 Finland
Obesity due to excess calories
2.0
6.1
68
360
D07AC13
ATC
mometasone; topical
1.6
6.1
186
1313
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.1
164
1124
38699, ,
ICD-8 Finland
12.7
6.1
10
8
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
6.1
88
509
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.7
6.1
32
123
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.3
6.0
22
68
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.3
6.0
47
217
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.3
6.0
43
191
SPAT1360
SPAT
Extensive global examination
2.3
6.0
43
191
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
125
725
1.89
8.67
5.5
4.8
32.17
32.06
%
0.03
75
484
299
2241
1.60
8.05
5.1
3.6
44.86
77.73
ng/l
0.51
216
1572
258
1888
1.59
7.56
4.2
2.6
66.59
63.50
u/l
0.13
241
1762
416
3420
1.56
7.16
6.1
4.9
6.77
6.70
mmol/l
0.29
386
3226
50
224
2.33
6.85
2.0
1.9
—
—
—
0
0
76
413
1.95
6.36
4.5
3.4
5.10
5.13
kpa
0.11
71
403
243
1814
1.53
6.26
2.4
2.1
184.26
222.59
u/l
0.27
235
1731
105
648
1.73
5.84
7.4
6.8
—
—
—
0
0
494
4322
1.53
5.60
5.5
4.4
12.00
11.81
mm/h
0.10
456
4044
140
953
1.59
5.32
2.0
1.9
—
—
—
0
0
43
206
2.16
5.07
2.1
1.7
—
—
—
0
0
150
1059
1.54
4.82
1.3
1.3
4.82
11.39
u/ml
1.43
63
406
62
347
1.87
4.77
4.2
3.4
1.52
1.82
mmol/l
0.32
49
265
252
1994
1.42
4.49
4.5
4.1
7.56
8.41
mg/mmol
0.09
147
1233
133
930
1.54
4.45
1.8
1.7
1126.75
1188.98
nmol/l
0.39
105
713
321
2661
1.39
4.33
13.6
12.6
1.18
1.21
inr
0.46
278
2206
112
763
1.56
4.20
9.2
5.6
1.09
1.04
mmol/l
1.03
104
708
196
1502
1.43
4.11
2.8
2.8
338.84
340.74
umol/l
0.08
167
1334
345
2910
1.38
4.11
9.4
7.0
1.21
1.21
mmol/l
0.03
293
2539
190
1453
1.43
4.02
2.5
2.4
—
—
—
0
0
39
200
2.01
3.90
1.4
1.6
—
—
—
0
0
19
72
2.69
3.76
1.3
1.3
—
—
—
0
0
74
469
1.65
3.74
4.9
3.7
119.29
78.22
ng/l
1.33
56
421
153
1140
1.44
3.70
1.4
1.3
39.73
32.85
iu/ml
0.19
43
352
257
2096
1.37
3.66
3.9
3.3
7.11
7.62
mmol/l
1.13
214
1796
495
4473
1.40
3.63
9.5
8.4
82.07
78.95
u/l
0.30
467
4248
308
2594
1.34
3.52
2.4
2.1
98.74
96.44
pmol/l
0.34
179
1354
14
47
3.02
3.43
1.0
1.2
—
—
—
0
0
195
1535
1.38
3.42
3.0
2.2
3.03
2.89
mg/l
0.45
169
1333
126
918
1.46
3.42
3.9
2.4
2.43
2.33
g/l
1.09
118
857
13
37
3.56
3.41
1.2
1.0
—
—
—
0
0
217
1739
1.37
3.41
5.2
3.8
0.00
0.01
estimate
0.96
80
608
9
18
5.05
3.38
1.0
1.1
—
—
—
0
0
83
557
1.56
3.33
4.8
3.5
2.25
1.81
mmol/l
0.32
70
475
14
48
2.96
3.31
1.0
1.2
—
—
—
0
0
306
2593
1.33
3.29
8.4
6.3
1.21
1.21
mmol/l
0.19
278
2404
21
90
2.38
3.27
1.5
1.3
—
—
—
0
0
34
178
1.96
3.25
1.5
1.5
240.00
280.86
ug/g
0.46
15
111
207
1663
1.35
3.16
1.8
1.7
20.58
20.77
nmol/l
0.06
162
1419
153
1172
1.39
3.14
1.7
1.7
43089883.80
34839791.90
pmol/l
0.07
123
996
495
4523
1.35
3.02
5.3
4.4
14.65
14.78
pmol/l
0.54
448
4164
130
977
1.41
2.97
3.9
3.3
0.81
0.82
mmol/l
0.61
122
934
84
582
1.51
2.93
2.2
2.0
341.61
384.44
nmol/l
1.22
74
550
49
298
1.69
2.93
5.8
3.5
46.89
47.55
%
0.06
49
290
115
849
1.43
2.90
3.9
2.4
21.27
22.91
%
0.75
106
802
131
991
1.40
2.88
4.0
2.4
12.56
13.10
umol/l
0.39
122
923
299
2560
1.30
2.86
5.7
5.1
35.68
35.87
g/l
0.25
282
2412
70
470
1.55
2.82
2.7
3.3
66.11
67.16
g/l
0.50
60
440
17
71
2.43
2.82
1.1
1.0
0.17
0.46
u/ml
—
8
20
29
152
1.95
2.79
2.1
1.5
—
—
—
0
0
308
2658
1.29
2.74
2.9
2.5
76.65
76.70
nmol/l
0.01
270
2408
49
306
1.65
2.67
1.5
1.4
—
—
—
0
0
13
49
2.69
2.63
2.0
1.2
3.47
0.55
u/ml
—
8
25
401
3595
1.28
2.59
3.1
3.1
—
—
—
0
0
567
5333
1.39
2.58
6.5
5.4
1.81
1.90
mu/l
1.15
523
4949
24
121
2.02
2.58
1.2
1.1
1.98
2.51
u/ml
0.13
12
64
8
20
4.04
2.57
1.0
1.2
—
—
—
0
0
356
3148
1.28
2.55
7.4
6.8
10.47
11.16
umol/l
0.87
337
3016
10
31
3.26
2.52
1.9
1.6
133.09
89.11
ng/l
—
10
31
599
5694
1.46
2.52
20.6
15.4
20.99
24.05
mg/l
1.44
514
4681
210
1740
1.30
2.51
4.0
3.2
1163.06
1082.07
ng/l
0.16
185
1494
11
37
3.00
2.49
2.2
1.5
72.64
74.89
umol/l
0.18
11
37
569
5363
1.39
2.49
7.8
6.4
40.57
39.28
mmol/mol
2.62
527
5050
8
21
3.84
2.47
1.0
1.2
109.00
106.25
%
—
8
16
62
424
1.51
2.33
1.7
1.6
—
—
—
0
0
436
3977
1.27
2.32
4.0
3.4
55.47
47.48
u/l
0.53
403
3769
53
351
1.55
2.30
2.5
3.7
4.48
4.60
pmol/l
0.22
48
313
60
409
1.51
2.29
1.8
1.2
220.75
275.39
u/ml
0.22
55
382
8
23
3.51
2.27
1.8
1.6
—
—
—
0
0
17
79
2.18
2.26
1.3
1.4
—
—
—
0
0
17
79
2.18
2.26
1.3
1.4
—
—
—
0
0
18
86
2.12
2.24
1.3
1.4
—
—
—
0
0
5
9
5.59
2.21
1.0
1.1
—
—
—
0
0
17
80
2.15
2.20
1.3
1.4
—
—
—
0
0
22
115
1.94
2.18
1.1
2.0
5.21
4.61
mmol/24h
0.18
16
98
9
30
3.03
2.15
1.1
1.0
1592.00
1686.37
miu/ml
—
9
30
157
1282
1.29
2.06
1.6
1.5
2.41
2.43
g/l
0.03
109
785
103
793
1.35
2.04
2.7
2.4
119.34
123.17
ug/g
0.06
82
638
22
118
1.89
2.04
9.4
7.2
592.83
159.50
iu/ml
—
6
18
29
171
1.73
2.00
2.9
3.6
1.06
2.70
ratio
2.09
24
104
56
389
1.48
1.98
2.9
2.5
23.44
20.37
au/ml
—
5
31
5
11
4.57
1.94
1.2
1.4
1.25
1.18
mmol/l
—
5
11
448
4798
0.80
1.93
21.4
19.1
13.77
13.59
%
1.47
440
4743
17
85
2.03
1.91
1.3
1.4
—
—
—
0
0
12
53
2.29
1.81
1.2
1.4
—
—
—
0
0
31
192
1.64
1.81
5.0
3.9
1.36
1.32
mmol/l
0.09
31
186
604
5809
1.38
1.80
24.1
18.1
3.98
3.97
mmol/l
0.46
587
5684
372
3386
1.22
1.80
10.2
9.9
4.18
4.05
e9/l
0.58
332
2974
63
457
1.42
1.80
2.7
2.5
60.75
68.03
ml/min/173m2
0.70
28
191
415
3820
1.22
1.79
5.6
4.5
11.50
2426.43
e6/l
—
6
65
45
307
1.50
1.76
1.1
1.0
—
—
—
0
0
603
5804
1.37
1.73
24.1
18.0
139.62
139.67
mmol/l
0.16
587
5690
7
24
2.94
1.72
1.0
1.0
—
—
—
0
0
13
61
2.15
1.72
1.0
1.1
—
—
—
0
0
11
48
2.31
1.71
1.1
1.1
—
—
—
0
0
8
31
2.60
1.66
1.6
1.3
—
—
—
0
0
231
2033
1.21
1.52
3.5
3.5
2.34
2.36
mmol/l
0.82
200
1843
38
259
1.50
1.52
2.1
1.8
4.80
8.22
iu/ml
0.61
11
67
16
86
1.88
1.51
1.3
1.4
—
—
—
0
0
28
178
1.60
1.51
1.5
1.3
—
—
—
0
0
28
178
1.60
1.51
1.7
1.2
—
2.37
—
0
9
12
58
2.09
1.50
1.0
1.1
—
—
—
0
0
33
219
1.53
1.49
1.6
1.6
14.30
9.62
u/ml
—
5
46
27
171
1.60
1.48
1.5
1.4
12.59
10.38
u/l
0.30
22
132
573
5504
1.27
1.45
6.1
5.1
6.11
5.93
mmol/l
1.69
518
5075
20
118
1.72
1.42
2.1
1.3
131.50
163.93
au/ml
—
6
37
27
174
1.57
1.39
1.5
1.2
—
—
—
0
0
11
53
2.09
1.39
1.1
1.2
—
—
—
0
0
170
1465
1.21
1.38
1.4
1.3
0.86
1.64
u/ml
1.09
52
409
89
715
1.28
1.34
1.9
1.8
—
—
—
0
0
25
160
1.58
1.33
1.4
1.3
—
—
—
0
0
308
2810
1.18
1.31
4.2
3.0
111.55
117.13
ug/l
0.23
283
2638
5
18
2.79
1.28
2.6
2.4
40.56
41.60
g/l
—
5
18
59
453
1.33
1.25
1.9
1.4
—
—
—
0
0
38
271
1.43
1.24
1.5
2.1
38.88
38.43
u/l
0.05
33
246
23
147
1.58
1.24
2.9
2.3
92.30
43.53
ug/min
0.55
13
85
303
2772
1.17
1.22
2.8
2.8
—
—
estimate
—
0
0
151
1306
1.20
1.18
3.4
2.6
6.24
5.30
e6/l
0.33
145
1203
30
207
1.47
1.17
2.0
2.1
1755.05
4112.70
u/l
—
10
89
54
414
1.33
1.16
1.2
1.3
235.10
130.75
u/ml
0.41
21
168
20
126
1.61
1.15
2.0
1.3
—
—
—
0
0
8
39
2.06
1.15
1.0
1.6
—
418.57
—
0
7
261
2378
1.16
1.08
4.9
3.7
0.05
0.03
estimate
0.10
66
541
16
97
1.67
1.07
4.0
1.8
—
—
—
0
0
15
90
1.68
1.04
1.3
1.4
0.22
0.38
nmol/l
—
10
72
153
1340
1.18
1.04
1.7
1.8
0.93
1.25
mg/l
1.96
125
1032
20
132
1.53
0.98
1.6
1.2
254.64
252.44
u/ml
0.01
11
74
226
2054
1.15
0.96
3.3
3.4
29.52
31.67
u/l
0.41
210
1946
333
3108
1.14
0.95
4.9
3.8
0.00
0.00
estimate
-0.00
84
643
80
665
1.23
0.94
8.6
7.7
1.61
0.82
mmol/l
0.88
65
558
17
110
1.56
0.91
6.7
2.3
10.09
7.88
pmol/l
0.74
17
110
11
63
1.76
0.90
1.3
1.7
—
—
—
0
0
11
63
1.76
0.90
1.3
1.7
—
—
—
0
0
11
63
1.76
0.90
1.3
1.7
—
—
—
0
0
335
3137
1.13
0.90
4.9
3.8
0.00
4.62
estimate
0.80
85
656
8
42
1.92
0.88
1.0
3.4
1712.25
827.31
mg
—
8
42
269
2488
1.13
0.87
2.0
1.9
1.44
1.36
mmol/l
0.89
223
2120
6
32
1.88
0.82
1.0
1.2
81.17
156.14
pmol/l
—
6
32
567
5516
1.17
0.80
18.6
14.7
82.12
82.12
ml/min/173m2
0.00
527
5102
79
672
1.20
0.77
2.0
1.9
—
—
—
0
0
6
34
1.77
0.76
1.2
2.0
—
—
—
0
0
6
34
1.77
0.76
1.2
2.0
—
—
—
0
0
6
34
1.77
0.76
1.2
2.0
—
—
—
0
0
6
34
1.77
0.76
1.2
2.0
—
—
—
0
0
613
6012
1.21
0.74
14.6
12.1
26.90
25.90
u/l
0.45
585
5852
9
55
1.64
0.73
2.6
2.5
—
—
—
0
0
7
39
1.80
0.72
1.0
1.2
—
—
—
0
0
7
39
1.80
0.72
1.4
1.8
10.27
7.42
mmol/l
—
7
39
617
6057
1.22
0.72
26.0
20.0
79.90
76.03
umol/l
1.12
602
5984
89
1021
0.85
0.71
3.1
3.0
0.69
0.76
ug/l
0.38
61
641
577
5637
1.16
0.69
5.8
5.0
1.42
1.48
mmol/l
2.61
532
5255
206
1902
1.12
0.67
4.0
3.2
40.39
94.73
e6/l
0.73
168
1448
586
5735
1.17
0.66
6.3
5.8
2.61
2.73
mmol/l
2.71
544
5351
21
154
1.38
0.65
1.2
1.2
—
—
—
0
0
22
163
1.36
0.65
1.8
2.1
2.21
38.93
iu/l
—
6
68
13
87
1.50
0.63
1.0
1.1
—
—
—
0
0
5
30
1.67
0.61
6.4
2.1
—
—
—
0
0
26
200
1.31
0.61
3.2
3.0
—
—
—
0
0
37
454
0.80
0.61
2.1
1.8
3.49
3.46
mmol/l
0.05
26
342
332
3159
1.10
0.60
5.0
3.8
0.32
0.51
estimate
0.13
78
610
20
149
1.35
0.58
4.3
1.8
—
—
—
0
0
25
193
1.31
0.58
2.6
2.7
0.93
1.24
g/l
0.15
20
171
6
35
1.72
0.58
1.3
1.3
—
—
—
0
0
6
35
1.72
0.58
1.3
1.3
—
—
—
0
0
24
185
1.31
0.57
1.6
1.5
—
—
—
0
0
631
6227
1.20
0.55
30.6
23.5
250.34
251.61
e9/l
0.20
620
6113
6
38
1.58
0.54
1.2
1.1
—
—
—
0
0
631
6228
1.20
0.54
30.4
23.4
90.83
91.02
fl
0.50
621
6167
6
39
1.54
0.53
1.2
1.8
—
—
—
0
0
6
98
0.61
0.52
1.0
1.3
—
—
—
0
0
6
98
0.61
0.52
1.0
1.3
—
—
—
0
0
631
6230
1.20
0.52
30.6
23.5
4.49
4.49
e12/l
0.05
618
6102
631
6230
1.20
0.52
31.1
23.9
40.23
40.33
%
0.19
621
6165
9
136
0.66
0.52
1.6
1.5
—
—
—
0
0
84
747
1.14
0.51
1.7
1.8
1.58
1.46
%
0.68
69
660
631
6233
1.19
0.49
30.8
23.7
135.12
135.15
g/l
0.02
621
6169
54
622
0.86
0.48
2.2
2.0
3.52
3.45
ratio
0.13
43
511
17
128
1.34
0.48
2.0
3.8
35.29
35.36
umol/l
0.01
17
118
14
102
1.38
0.47
6.1
3.0
—
3962.43
—
0
7
55
478
1.16
0.46
2.2
2.4
11.89
13.66
nmol/l
1.10
49
441
175
1634
1.10
0.46
3.4
3.1
0.46
0.40
e6/l
0.19
137
1186
70
620
1.14
0.46
2.5
1.9
—
—
—
0
0
110
1003
1.12
0.46
3.0
2.8
1.65
0.90
e6/l
1.01
67
516
7
49
1.43
0.46
1.4
1.4
1.11
1.16
promille
—
7
41
576
5661
1.12
0.46
5.9
5.1
4.53
4.67
mmol/l
2.86
537
5308
549
5387
1.10
0.43
5.1
4.3
1.38
1.28
mmol/l
2.33
498
4990
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
5
32
1.57
0.42
1.2
1.1
—
—
—
0
0
127
1175
1.10
0.41
2.8
3.0
2.44
2.45
mmol/l
0.24
111
1053
41
352
1.18
0.41
1.6
1.6
—
—
—
0
0
15
114
1.32
0.41
2.1
1.8
—
—
—
0
0
5
34
1.47
0.40
1.4
1.4
2.60
2.39
u/field
—
5
24
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
19
151
1.27
0.39
5.7
2.9
0.28
0.35
iu/ml
0.68
11
82
75
678
1.12
0.38
2.5
2.8
10.45
7.75
umol/l
0.29
67
604
9
71
1.27
0.36
3.9
2.7
1.20
1.19
mmol/l
—
9
71
75
681
1.11
0.36
2.4
2.1
—
—
—
0
0
123
1146
1.09
0.35
1.6
1.6
—
—
—
0
0
9
123
0.73
0.35
1.4
1.4
—
—
—
0
0
22
181
1.22
0.35
8.0
3.0
1.93
1.46
mg/l
0.94
22
163
36
312
1.16
0.34
1.7
1.9
—
—
—
0
0
23
193
1.20
0.31
1.3
2.4
10.10
10.67
g/l
0.45
18
176
19
157
1.22
0.29
1.6
1.5
12296.85
13098.96
e6/l
0.03
13
114
12
94
1.28
0.28
1.2
1.1
—
1.96
—
0
20
12
94
1.28
0.28
1.0
1.1
1.65
1.50
g/l
1.31
12
87
8
62
1.29
0.28
1.1
1.2
—
—
—
0
0
8
64
1.25
0.27
1.4
2.1
13.30
13.12
%
—
8
64
8
67
1.20
0.26
2.3
4.2
—
—
—
0
0
5
75
0.66
0.26
1.0
1.5
—
—
—
0
0
9
72
1.25
0.25
1.0
1.5
—
—
—
0
0
9
72
1.25
0.25
3.9
2.7
105.00
105.64
mmol/l
—
9
72
15
123
1.22
0.25
2.3
1.5
—
—
—
0
0
9
77
1.17
0.24
1.1
1.1
—
—
—
0
0
117
1108
1.07
0.24
5.1
3.7
51.80
338.30
ng/l
4.31
80
847
17
201
0.84
0.24
1.2
1.1
1.46
1.55
g/l
0.82
17
201
21
181
1.17
0.22
1.6
1.3
—
—
—
0
0
7
95
0.73
0.22
1.1
1.5
—
—
—
0
0
18
210
0.85
0.22
1.2
1.2
0.83
0.92
g/l
1.11
18
210
5
41
1.22
0.22
1.0
1.6
—
25.88
—
0
8
14
167
0.83
0.22
1.2
2.3
0.00
0.03
g/l
0.50
14
153
0
11
0.00
0.21
0.0
1.0
—
1.02
—
0
6
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
109.00
—
0
10
0
10
0.00
0.21
0.0
1.1
—
40.86
—
0
5
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
38.70
—
0
10
146
1399
1.06
0.21
5.5
3.8
1.02
1.02
kg/l
0.33
101
928
0
12
0.00
0.21
0.0
2.1
—
2.76
—
0
5
11
89
1.24
0.21
1.0
1.3
1.80
6.69
u/ml
—
5
39
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.25
0.20
1.2
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
0.66
—
0
9
6
49
1.23
0.20
1.2
1.2
—
—
—
0
0
6
49
1.23
0.20
1.2
1.2
—
—
—
0
0
6
51
1.18
0.19
1.2
1.2
—
—
—
0
0
6
51
1.18
0.19
1.2
1.2
—
—
—
0
0
17
196
0.86
0.19
1.6
1.3
—
—
—
0
0
6
53
1.13
0.18
1.0
1.2
112.67
107.57
pmol/l
—
6
53
19
166
1.15
0.18
1.1
1.1
—
—
—
0
0
7
59
1.19
0.18
6.1
3.1
29.29
48.83
u/ml
—
7
59
5
66
0.76
0.17
1.6
2.1
—
—
—
0
0
19
167
1.14
0.17
1.1
1.1
—
—
—
0
0
59
626
0.94
0.16
3.0
4.5
3.57
29.47
ug/l
1.29
46
523
18
203
0.88
0.15
1.8
1.5
—
—
—
0
0
9
80
1.13
0.15
1.0
1.1
—
—
—
0
0
9
82
1.10
0.15
1.0
1.2
—
—
—
0
0
9
83
1.09
0.14
1.1
1.3
0.49
22.38
nmol/l
—
9
78
60
568
1.06
0.14
3.3
3.1
—
—
—
0
0
13
149
0.87
0.13
1.2
2.5
0.00
0.00
g/l
-0.00
13
142
23
252
0.91
0.13
2.0
3.7
23.76
874.06
u/ml
1.73
16
219
15
168
0.89
0.12
1.5
1.7
—
—
—
0
0
11
95
1.16
0.11
1.5
1.6
39.45
51.13
ug/l
0.76
11
95
14
124
1.13
0.11
1.5
1.7
—
—
—
0
0
6
56
1.07
0.08
1.2
1.2
—
—
—
0
0
7
64
1.09
0.08
1.7
1.4
3.82
3.00
ug/l
—
7
52
7
65
1.08
0.08
1.0
1.2
—
—
—
0
0
150
1472
1.02
0.07
4.6
4.0
93.93
91.19
%
0.77
145
1448
133
1356
0.98
0.07
3.8
4.4
21.29
21.44
%
0.04
61
631
13
118
1.10
0.07
1.3
1.5
—
—
—
0
0
19
177
1.08
0.06
1.3
1.5
—
—
—
0
0
171
1685
1.02
0.06
5.5
5.2
1.85
2.66
ug/l
1.06
156
1533
17
158
1.08
0.06
1.3
1.6
—
—
—
0
0
95
930
1.03
0.06
1.6
1.5
—
—
—
0
0
29
304
0.95
0.06
1.3
1.3
—
—
—
0
0
15
161
0.93
0.05
1.0
1.1
—
5.76
—
0
20
19
201
0.94
0.04
1.1
1.3
193.56
254.28
miu/ml
—
9
97
13
121
1.08
0.03
4.0
4.1
35.20
27.93
mg/l
—
5
87
26
270
0.96
0.03
1.3
1.6
0.43
0.34
mg/l
0.31
12
125
171
1722
0.99
0.02
4.1
3.2
0.00
0.06
estimate
0.60
70
522
37
378
0.98
0.01
1.9
2.0
—
—
—
0
0
16
167
0.96
0.01
1.4
1.1
—
3.91
—
0
26
22
213
1.03
0.01
2.2
1.8
—
—
—
0
0
11
104
1.06
0.01
1.0
1.8
—
—
—
0
0
12
122
0.98
0.00
1.4
1.5
—
—
—
0
0
93
925
1.01
0.00
3.1
2.9
4.54
2.63
e6/l
0.50
47
440
14
142
0.99
0.00
1.5
2.0
175.36
214.65
pmol/l
0.91
14
133
14
139
1.01
0.00
1.3
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
7
78
0.90
-0.00
1.6
1.6
—
—
—
0
0
5
50
1.00
-0.00
5.0
1.9
15.14
23.53
nmol/l
—
5
45
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
12.62
—
0
6
6
63
0.95
-0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
74
0.95
-0.00
1.4
1.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_EXT_NONINF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_NONINF | 1.437 [1.24, 1.66] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 2245 females with H8_EXT_NONINF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_NONINF | 1.369 [1.2, 1.56] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 486 out of 2048 males with H8_EXT_NONINF died.
Mortality risk
Mortality risk for people of age
years, who have H8_EXT_NONINF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.152% | 0.252% |
| 5 | 0.83% | 1.636% |
| 10 | 2.1% | 4.116% |
| 15 | 3.908% | 7.577% |
| 20 | 6.395% | 13.316% |
Relationships between endpoints
↥Index endpoint: H8_EXT_NONINF – Acute otitis externa, noninfective
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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