Other specified/unspecified disorders of ear

H8_EARNAS

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H93.8, H93.9 Hospital discharge: ICD-9 — 388[8-9] Cause of death: ICD-10 — H93.8, H93.9 Cause of death: ICD-9 — 388[8-9] 2 out of 7 registries used, show all original rules.	137
4. Check minimum number of events None	137
5. Include endpoints None	137
6. Filter based on genotype QC (FinnGen only)	120

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	H8_EARNAS
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H93[8-9]
HD_ICD_9	388[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H93[8-9]
COD_ICD_9	388[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other specified/unspecified disorders of ear based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	846	451	389
Only index persons	716	406	310
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	46.76	50.76	41.95
Only index persons	48.46	51.62	44.31

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	120	83	37
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	55.98	54.48	59.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
126: Matched controls
1260

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H93.9

ICD-10 Finland

Disorder of ear, unspecified

1146.1

68.8

H93.8

ICD-10 Finland

Other specified disorders of ear

+∞

57.8

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

49.6

30.4

Z01.1

ICD-10 Finland

Examination of ears and hearing

8.2

21.3

DFF00

NOMESCO Finland

Pure tone audiometry

17.8

16.7

H90.4

ICD-10 Finland

Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

119.5

10.6

Z3229

NOMESCO Finland

Other healthcare associate professional

5.9

10.2

H93.1

ICD-10 Finland

Tinnitus

18.7

10.2

H92.0

ICD-10 Finland

Otalgia

8.4

10.0

N07CA01

ATC

betahistine; oral

5.8

9.9

UDC00

NOMESCO Finland

Ear microscopy

8.1

8.6

H29

ICPC

Ear symptom/complaint other

4.0

8.5

3888X

ICD-9 Finland

Other disorders of ear

+∞

8.4

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

3.3

7.7

130

R01AD58

ATC

fluticasone, combinations; nasal

2.9

6.8

192

3889X

ICD-9 Finland

Other disorders of ear, Unspecified disorder of ear

+∞

6.3

L01

ICPC

Neck symptom/complaint

3.0

6.3

133

H66.9

ICD-10 Finland

Otitis media, unspecified

4.3

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768797) Stomach Pathology biopsy report

136

2.58

4.47

1.4

1.2

—

(3019198) Lymphocytes [#/volume] in Blood

594

2.24

4.36

5.5

6.2

2.00

1.84

e9/l

0.90

526

(3013115) Eosinophils [#/volume] in Blood

600

2.20

4.17

5.6

6.6

0.19

0.18

e9/l

0.31

527

(3001604) Monocytes [#/volume] in Blood

581

2.18

4.14

5.6

6.1

0.56

0.55

e9/l

0.09

500

(3006315) Basophils [#/volume] in Blood

583

2.16

4.08

5.6

6.2

0.03

0.04

e9/l

1.24

501

(3007853) Bacteria identified in Skin by Aerobe culture

123

2.52

3.96

1.9

1.7

—

(40768804) Tissue Pathology biopsy report

466

2.06

3.86

2.3

2.0

—

(42870588) Differential panel, method unspecified - Blood

361

2.06

3.78

5.8

6.2

—

(40768795) Lymph node Pathology biopsy report

6.49

3.56

1.0

1.1

—

(3048689) Calprotectin [Mass/mass] in Stool

148

2.25

3.29

3.1

2.0

165.33

74.94

ug/g

0.53

114

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

120

1069

3.57

3.15

19.3

14.8

18.57

23.11

mg/l

1.06

105

869

(3021589) Normoblasts [#/volume] in Blood

490

1.90

3.12

10.2

10.5

0.00

e9/l

-0.00

386

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.53

3.06

2.6

1.0

—

(3044640) Blood type and Crossmatch panel - Blood

353

1.87

2.86

2.5

2.3

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.50

2.72

1.2

1.8

1.29

1.71

g/l

0.37

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

524

1.81

2.71

9.3

7.3

1.22

1.21

mmol/l

0.70

449

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

248

1.90

2.67

1.9

1.7

0.79

1.13

mg/l

0.47

185

(3044941) Cell count panel - Synovial fluid

4.87

2.63

3.0

1.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

259

1.86

2.57

2.9

2.2

2.39

2.64

mg/l

0.38

229

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

392

1.77

2.50

3.9

3.3

16.21

36.84

ng/l

1.33

259

(3021788) Differential panel - Synovial fluid

5.19

2.43

3.0

1.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

586

1.75

2.38

6.5

7.3

18.28

11.10

umol/l

0.65

554

(3013650) Neutrophils [#/volume] in Blood by Automated count

636

1.77

2.38

8.3

11.2

4.07

4.03

e9/l

0.06

553

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

3.26

2.27

1.6

2.0

14.04

11.07

mg/l

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

3.01

2.26

1.4

1.8

—

11.94

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

636

1.71

2.15

6.5

4.9

6.78

6.49

mmol/l

0.41

587

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

205

1.83

2.15

4.8

3.6

378.50

284.90

ng/l

0.10

147

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.64

2.08

1.1

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.64

2.08

1.1

1.4

—

(3022145) Colonoscopy Study observation

113

2.03

2.07

1.9

1.3

—

(40761511) CBC panel - Blood by Automated count

120

1101

2.89

2.06

17.1

12.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

101

864

1.85

2.02

5.6

4.4

15.06

14.68

pmol/l

0.81

791

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

2.70

1.99

1.4

1.7

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.58

1.99

3.5

2.2

36.73

46.26

u/l

1.18

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

114

1021

2.22

1.91

20.6

14.1

86.20

83.23

ml/min/173m2

0.74

107

933

(3007164) IgA [Mass/volume] in Serum or Plasma

264

1.69

1.88

1.6

1.5

2.56

2.27

g/l

0.42

159

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

273

1.68

1.87

2.4

2.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

522

1.61

1.84

3.0

2.7

—

estimate

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

173

1.80

1.84

3.9

3.0

3.00

3.71

e6/l

0.21

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.69

1.84

1.3

—

(40758558) Short blood count panel - Blood

337

1.63

1.81

5.6

7.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

3.45

1.77

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

737

1.64

1.76

3.2

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

121

1128

2.83

1.75

14.0

11.8

28.15

25.77

u/l

0.46

115

1100

(3005322) IgE [Units/volume] in Serum or Plasma

2.11

1.73

1.3

134.71

134.26

u/ml

0.00

(4035726) Immunohistochemistry procedure

1.98

1.72

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

193

1.73

1.72

3.8

2.9

0.62

1.04

e6/l

0.55

(3002256) Pathology report gross observation

145

1.81

1.70

1.2

—

(3030467) Casts [#/volume] in Urine by Automated count

306

1.62

1.69

4.7

3.1

0.49

0.44

e6/l

0.07

208

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.36

1.69

1.1

1.4

0.38

0.16

mg/l

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

3.67

1.63

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.79

1.60

1.3

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

172

1.73

1.60

1.7

1.9

—

(3044290) Cell count panel - Cerebral spinal fluid

3.10

1.60

1.0

1.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

214

1.66

1.59

1.7

1.3

12.63

27.36

iu/ml

—

(3032080) INR in Blood by Coagulation assay

460

1.53

1.54

16.6

10.3

1.33

1.19

inr

0.56

387

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

3.42

1.54

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

3.42

1.54

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

3.42

1.54

1.2

—

(3018333) Ribosomal P Ab [Presence] in Serum

3.42

1.54

1.2

—

(3018095) Leukocytes [#/volume] in Urine

423

1.53

1.52

6.1

3.8

114.54

67.09

e6/l

0.26

274

(3019309) Folate [Moles/volume] in Red Blood Cells

167

1.70

1.50

1.7

1269.53

1142.44

nmol/l

0.31

135

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.14

1.49

1.8

1.7

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

815

1.60

1.49

5.6

4.2

10.81

11.32

mm/h

0.16

760

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.59

1.47

1.0

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.41

1.46

1.1

1.7

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

334

1.54

1.45

3.3

2.5

122.79

67.14

u/l

0.39

311

(3019225) pH of Specimen

1.91

1.45

6.1

4.6

7.39

7.36

1.01

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.91

1.45

1.2

108.29

167.24

u/ml

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

3.21

1.45

1.2

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

3.21

1.45

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

128

1.77

1.44

1.8

1.6

—

(3002582) Erythrocytes [#/volume] in Urine

363

1.52

1.42

4.9

3.1

24.02

46.96

e6/l

0.64

264

(36660697) Celiac disease serology panel - Serum

106

1.81

1.38

1.4

1.2

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.69

1.38

2.7

10.3

—

141.80

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.92

1.38

1.6

1.4

—

(3000494) Fungus identified in Specimen by Culture

131

1.72

1.34

2.1

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

198

1.60

1.33

1.5

1.3

1.46

13.35

u/ml

—

(3026008) Bacteria identified in Urine by Culture

340

1.50

1.32

3.1

2.8

—

(3049717) Cytology report of Urine Cyto stain

2.44

1.32

1.4

2.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

501

1.47

1.30

3.7

2.6

76.20

76.93

nmol/l

0.07

460

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

124

1.73

1.30

1.8

1.7

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.47

1.26

2.0

1.4

—

(3024928) Oxygen saturation in Venous blood

2.47

1.26

14.3

2.8

62.98

57.93

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.47

1.26

2.0

1.4

—

(3023368) Bacteria identified in Blood by Culture

280

1.51

1.25

5.6

4.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.93

1.25

1.0

—

(3034770) Mitochondria Ab [Titer] in Serum

2.24

1.24

1.0

1.1

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

299

1.49

1.23

2.5

3.1

899.10

1207.82

ng/l

0.52

246

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

299

1.49

1.23

1.7

1.3

0.65

3.24

u/ml

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

2.70

1.22

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

448

1.45

1.22

2.4

2.1

95.83

98.75

pmol/l

0.15

225

(36304419) Bacteria [Presence] in Urine

301

1.48

1.19

4.1

2.9

—

estimate

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

110

1009

1.71

1.18

6.8

5.5

1.99

1.85

mu/l

0.59

943

(3015736) pH of Urine

480

1.43

1.16

4.1

3.4

6.41

6.27

0.42

269

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.07

1.14

1.0

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.90

1.13

1.4

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.33

1.12

1.0

1.2

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.01

1.11

1.1

—

(3026493) Urate [Moles/volume] in Serum or Plasma

269

1.47

1.10

3.1

2.9

318.63

332.21

umol/l

0.36

240

(3021601) Nitrite [Presence] in Urine by Test strip

592

1.41

1.09

4.6

3.7

0.00

estimate

-0.00

115

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

112

1038

1.71

1.08

5.2

4.7

5.78

5.86

mmol/l

0.25

966

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

108

993

1.61

1.06

7.6

5.8

39.06

38.42

mmol/mol

0.30

943

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

132

1.61

1.05

6.0

4.5

38.75

33.33

0.91

(40768443) Skin Pathology biopsy report

1.98

1.05

1.2

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.32

1.04

1.2

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.32

1.04

1.4

1.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.06

1.01

1.3

1.7

—

(3037522) Nuclear Ab [Titer] in Serum

159

1.55

1.00

1.8

1.3

620.00

563.81

titre

—

(3035350) Ketones [Presence] in Urine by Test strip

600

1.38

0.97

4.5

3.7

0.00

13.76

estimate

0.50

118

(3042936) Bacteria identified in Isolate by Culture

152

1.54

0.96

2.4

1.9

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

2.20

0.93

1.3

1.1

—

0.82

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

180

1.49

0.91

2.0

1.7

417.72

462.01

pmol/l

0.34

155

(3009261) Glucose [Presence] in Urine by Test strip

605

1.35

0.89

4.6

3.7

0.00

estimate

-0.00

109

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.64

0.89

2.2

2.4

0.20

0.23

g/l

0.63

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

247

1.40

0.82

1.7

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

257

1.38

0.80

2.1

2.0

—

(3023520) Reticulocytes [#/volume] in Blood

1.61

0.79

1.3

3.3

62.91

76.80

e9/l

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

2.22

0.77

1.2

1.3

4.66

3.50

mmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

100

1.57

0.77

4.6

3.1

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

110

1.52

0.72

1.8

4.9

4.02

9.84

ug/l

—

(40761536) Microorganisms panel - Urine sediment

1.59

0.72

3.2

3.1

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

1.96

0.71

1.2

1.3

1.40

2.05

e6/l

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

1.96

0.71

1.4

1.5

38.00

234.43

e6/l

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

1.96

0.71

1.0

1.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.75

0.71

1.3

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

106

994

1.42

0.69

4.3

4.1

1.30

1.24

mmol/l

0.31

922

(3035933) Granulocytes/Leukocytes in Blood

1.82

0.67

1.4

2.2

67.00

59.37

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.61

0.60

1.3

1.4

30.38

24.45

iu/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.54

0.59

2.6

2.1

—

(3018418) pH of Serum or Plasma

335

1.28

0.59

6.3

4.1

7.41

7.39

0.99

245

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

112

1068

1.44

0.57

6.0

5.5

2.68

2.71

mmol/l

0.11

999

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.47

0.57

1.2

1.5

—

(3000492) Spirometry study

108

1.44

0.56

1.4

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

144

1.38

0.54

1.6

1.8

—

(3022313) Gas panel - Capillary blood

1.52

0.52

2.0

5.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.53

0.51

8.8

7.7

25.32

25.12

mmol/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

457

1.23

0.51

2.2

1.9

1.30

1.41

mmol/l

0.53

388

(3012516) Albumin [Mass/volume] in Urine

332

1.25

0.50

3.9

3.5

33.29

64.45

mg/l

0.73

214

(3015377) Calcium [Moles/volume] in Serum or Plasma

390

1.24

0.50

3.2

3.6

2.37

2.35

mmol/l

0.42

364

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

229

1.29

0.49

2.0

1.7

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.49

0.46

1.5

1.1

—

(3009508) Creatinine [Moles/volume] in Urine

365

1.23

0.45

3.8

3.2

6.33

7.51

mmol/l

1.26

311

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

139

0.70

0.45

1.7

1.5

1.38

1.35

—

118

(1761868) Lipid panel - Serum or Plasma

414

1.22

0.44

4.0

3.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

337

1.23

0.44

5.2

4.0

3.86

10.16

mg/mmol

1.39

213

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.64

0.43

1.6

1.3

50.06

37.13

nmol/l

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.54

0.42

1.6

5.7

24.34

24.39

mmol/l

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.41

0.0

1.4

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.36

0.41

14.9

3.4

24.50

24.58

mmol/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

109

1047

1.30

0.41

5.6

4.8

1.47

1.50

mmol/l

0.21

977

(3041096) Erythrocytes [Presence] in Urine by Automated

321

1.22

0.40

3.8

3.0

0.00

estimate

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.40

0.38

2.4

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.41

0.35

3.0

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.38

0.35

1.8

1.4

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

773

1.17

0.33

3.9

3.1

61.38

46.51

u/l

0.69

738

(1002224) Polysomnography panel

1.34

0.31

1.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

109

1055

1.25

0.31

5.4

4.8

4.55

4.65

mmol/l

0.50

991

(3019150) Specific gravity of Urine by Refractometry

268

0.83

0.30

4.5

3.6

1.01

1.02

kg/l

0.52

178

(3009343) pH of Capillary blood

1.26

0.30

1.9

4.2

7.44

7.42

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

447

1.16

0.30

3.9

3.5

0.09

0.00

estimate

0.47

(40760892) CBC W Ordered Manual Differential panel - Blood

273

1.18

0.29

2.6

4.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.25

0.26

1.3

2.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

220

1.17

0.23

2.3

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.29

0.23

2.4

1.7

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.26

0.22

2.4

1.6

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.26

0.22

1.2

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.26

0.22

1.0

2.1

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

1.23

0.22

1.4

2.2

0.00

g/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

1.23

0.22

1.4

2.2

0.00

g/l

—

(3029937) Albumin [Presence] in Urine by Test strip

328

1.14

0.22

3.6

3.7

0.00

estimate

-0.00

104

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

15.2

—

0.72

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

0.21

0.0

1.6

—

8.27

—

(3000991) Gas panel - Venous blood

1.23

0.20

16.4

9.1

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.20

0.0

1.2

—

13.29

—

(3021960) Folate [Moles/volume] in Serum or Plasma

301

1.13

0.19

1.6

21.76

23.21

nmol/l

0.28

253

(3027801) Oxygen [Partial pressure] in Arterial blood

119

0.83

0.16

8.4

8.0

10.51

12.62

kpa

—

113

(3019977) pH of Arterial blood

119

0.83

0.16

8.4

8.1

7.45

7.42

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

119

0.83

0.16

8.4

8.0

4.71

5.10

kpa

—

112

(3025941) Bacteria identified in Stool by Culture

0.77

0.16

1.2

1.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

140

1.16

0.16

11.6

7.4

103.62

104.44

mmol/l

0.29

140

(3021879) Hepatitis B virus core Ab [Presence] in Serum

102

1.20

0.16

2.2

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.15

0.15

2.1

2.0

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

915

1.11

0.15

26.2

18.1

13.54

13.63

0.31

905

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.76

0.15

7.6

4.0

67.00

78.90

ng/l

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

122

1.17

0.14

3.1

4.4

208.71

234.54

u/l

0.67

117

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

124

1.15

0.12

4.4

7.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

136

0.87

0.11

1.3

1.7

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

1.17

0.10

1.4

2.1

0.00

g/l

—

(3008898) HLA-B27 [Presence]

1.09

0.09

1.0

1.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.07

0.09

3.2

2.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.04

0.09

1.2

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.04

0.09

1.2

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.04

0.09

1.2

1.1

—

(3016879) Cocaine [Presence] in Urine

1.04

0.09

1.2

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.15

0.09

2.3

2.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.10

0.09

1.7

1.4

—

(3019060) Gas panel - Arterial blood

0.83

0.08

1.6

3.7

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.83

0.08

12.3

9.9

0.50

0.61

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.83

0.08

12.3

10.0

1.57

1.19

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

108

1.12

0.07

2.7

2.1

316.67

379.58

nmol/l

0.54

(3017143) Hepatitis C virus Ab [Presence] in Serum

157

1.10

0.07

1.9

1.5

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

934

0.94

0.06

26.7

19.3

332.16

331.92

g/l

0.10

934

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

139

1.09

0.05

2.0

—

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

1.12

0.05

1.6

2.0

2.90

3.37

mmol/l

—

(3002032) Base excess in Venous blood by calculation

102

1.09

0.03

13.6

3.5

1.95

2.03

mmol/l

0.03

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

138

0.94

0.02

2.1

2.9

0.41

0.71

ug/l

—

(3003694) ABO and Rh group [Type] in Blood

339

0.96

0.02

1.7

1.5

—

(21494755) Public health laboratory ask at order entry panel

114

0.96

0.00

1.0

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

124

0.96

0.00

2.1

2.0

3.43

3.17

ratio

—

107

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

126

1.04

0.00

1.8

1.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

156

1.03

0.00

2.4

2.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

178

1.01

0.00

3.2

4.3

20.33

23.63

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.88

-0.00

1.1

1.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.89

-0.00

17.0

2.3

0.70

1.19

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

127.43

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.91

-0.00

17.0

2.3

0.56

0.63

—

(3000764) Benzodiazepines [Presence] in Urine

0.94

-0.00

1.2

1.3

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.5

—

10.63

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.5

—

4.57

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

3.2

—

16.18

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.8

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.95

-0.00

15.5

3.0

119.33

128.60

g/l

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3027008) Opiates [Presence] in Urine

0.94

-0.00

1.2

1.3

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.4

—

331.14

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

2.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

2.4

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

2.6

—

45.12

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

8.8

—

1056.56

—

(3010503) CD19 cells [#/volume] in Blood

0.00

-0.00

0.0

2.0

—

179.33

—

(3027944) Amphetamines [Presence] in Urine

0.91

-0.00

1.2

1.3

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.1

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

2.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.6

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

11.89

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.98

-0.00

10.2

6.6

17.52

15.62

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

0.94

-0.00

1.2

1.3

—

(4198724) Urine methamphetamine measurement

0.00

-0.00

0.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

18.48

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.1

—

8.54

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3017704) Immunofixation for Urine

0.00

-0.00

0.0

1.9

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

3.2

—

0.50

—

(4024509) Urine culture

0.96

-0.00

2.2

1.9

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.2

—

26.50

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

30.72

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_EARNAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_EARNAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_EARNAS – Other specified/unspecified disorders of ear

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified/unspecified disorders of ear

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints