No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
435 |
4. Check minimum number of eventsNone |
435 |
5. Include endpointsNone |
435 |
6. Filter based on genotype QC (FinnGen only) |
379 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amblyopia unius oculi
Similar endpoints
↥List of similar endpoints to
Severe visual impairment, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2596 | 1398 | 1186 |
| Only index persons | 2197 | 1205 | 992 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 50.93 | 57.12 | 43.50 |
| Only index persons | 56.01 | 61.87 | 48.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 379 | 233 | 146 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.07 |
| Median age at first event (years) | 67.22 | 65.66 | 69.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 397
- Matched controls
- 3970
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.5
ICD-10 Finland
Severe visual impairment, monocular
4503599627370496.0
307.7
393
7
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
10.3
74.6
95
118
H53.1
ICD-10 Finland
Subjective visual disturbances
16.9
65.2
57
39
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.8
47.7
107
239
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.8
47.1
105
233
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
6.6
40.4
72
128
XCK00
NOMESCO Finland
Perimetry
6.6
39.0
70
125
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.1
37.8
141
466
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
110.9
37.5
40
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.1
37.1
137
449
S01ED51
ATC
timolol, combinations; ophthalmic
5.3
36.6
85
193
S01EA05
ATC
brimonidine; ophthalmic
9.0
31.8
41
50
H53.9
ICD-10 Finland
Visual disturbance, unspecified
12.8
31.1
31
26
CS494
NOMESCO Finland
Other visual field testing
10.0
29.6
35
38
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
5.6
27.7
57
115
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
5.1
27.5
64
144
H53.0
ICD-10 Finland
Amblyopia ex anopsia
104.0
27.0
29
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.3
26.5
80
222
WX140
NOMESCO Finland
Parabulbar anesthesy
5.7
25.7
52
103
114
Kela drug reimbursment
Glaucoma
4.1
25.0
79
226
S01EC01
ATC
acetazolamide; systemic
8.5
24.6
33
42
S01ED01
ATC
timolol; ophthalmic
6.5
24.4
42
71
H34.8
ICD-10 Finland
Other retinal vascular occlusions
8.3
22.9
31
40
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.8
22.6
211
1143
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
21.3
228
1312
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
4.7
21.2
53
126
H53.4
ICD-10 Finland
Visual field defects
116.2
20.8
22
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.9
20.6
29
39
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
20.2
20.3
30
16
H43.1
ICD-10 Finland
Vitreous haemorrhage
8.1
20.2
28
37
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
40.6
18.8
23
6
XCH00
NOMESCO Finland
Eye pressure measurement
4.8
18.5
45
104
H57.1
ICD-10 Finland
Ocular pain
5.5
17.3
35
69
S01EE01
ATC
latanoprost; ophthalmic
3.9
17.2
55
157
H53.2
ICD-10 Finland
Diplopia
25.8
16.2
22
9
H54.4
ICD-10 Finland
Blindness, monocular
+∞
15.7
15
*
H26.02
ICD-10 Finland
Presenil cataract
6.8
15.1
24
37
H33.0
ICD-10 Finland
Retinal detachment with retinal break
5.3
14.8
31
63
H25.1
ICD-10 Finland
Senile nuclear cataract
2.3
14.4
169
964
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.0
14.0
31
66
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.7
13.9
87
371
H26.4
ICD-10 Finland
After-cataract
2.9
13.8
73
284
AA1AD
NOMESCO Finland
CT of head and brain
2.3
13.7
151
836
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.2
13.6
179
1066
H34.1
ICD-10 Finland
Central retinal artery occlusion
41.6
13.2
16
*
H25.8
ICD-10 Finland
Other senile cataract
2.7
12.8
76
315
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
25.3
12.6
17
7
S01EC54
ATC
brinzolamide, combinations; ophthalmic
10.5
12.2
23
23
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
11.9
52
181
H47.2
ICD-10 Finland
Optic atrophy
67.0
11.7
13
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
4.8
11.6
27
60
S01EE03
ATC
bimatoprost; ophthalmic
5.4
11.4
23
45
H50.1
ICD-10 Finland
Divergent concomitant strabismus
25.9
11.2
15
6
S01EE05
ATC
tafluprost; ophthalmic
4.2
11.0
30
76
S01BC05
ATC
ketorolac; ophthalmic
4.0
10.8
32
86
H04.10
ICD-10 Finland
Dry eye syndrome
2.7
10.3
61
251
SPAT1234
SPAT
Support of social functional capacity
3.5
10.0
35
106
TAB00
NOMESCO Finland
Lumbar puncture
3.8
9.7
30
83
E0000UV, ,
ATC
1.9
9.5
178
1168
CKC12
NOMESCO Finland
Photocoagulation of retina
4.0
9.4
27
71
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
9.4
212
1479
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.6
9.1
56
234
F05
ICPC
Visual disturbance other
4.4
9.0
23
55
H26.2
ICD-10 Finland
Complicated cataract
11.1
8.9
16
15
H40.0
ICD-10 Finland
Glaucoma suspect
2.8
8.7
46
178
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.7
8.6
27
76
37300
ICD-8 Finland
Strabismus, Concomitans convergens
20.6
8.5
12
6
H3603, E103,
ICD-10 Finland
20.6
8.5
12
6
S01EC04
ATC
brinzolamide; ophthalmic
3.5
8.4
29
87
R51.80
ICD-10 Finland
Headache
2.2
8.3
77
387
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
14.9
8.3
13
9
H16.0
ICD-10 Finland
Corneal ulcer
3.4
8.1
29
89
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.5
8.0
28
85
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
7.8
66
320
S01EE04
ATC
travoprost; ophthalmic
4.7
7.7
18
40
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
7.7
49
208
Z2445
NOMESCO Finland
Psychologist
3.7
7.7
24
67
J01DB01
ATC
cefalexin; oral
2.2
7.7
331
2773
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
7.5
69
345
T89
ICPC
Diabetes insulin dependent
3.6
7.4
24
69
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
16.1
7.3
11
7
H52.1
ICD-10 Finland
Myopia
3.9
7.2
21
56
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
7.2
60
289
Z2446
NOMESCO Finland
Social worker
2.8
7.1
37
142
H25.0
ICD-10 Finland
Senile incipient cataract
2.8
7.1
37
142
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
4.0
7.1
20
52
CKD40
NOMESCO Finland
Endophotocoagulation of retina
6.5
7.0
17
27
H20.1
ICD-10 Finland
Chronic iridocyclitis
14.1
6.9
11
8
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.7
6.9
39
156
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.6
6.8
40
163
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.3
6.8
17
28
Z94.0
ICD-10 Finland
Kidney transplant status
11.2
6.8
12
11
N06AX26
ATC
vortioxetine; oral
2.7
6.8
36
139
Z49.1
ICD-10 Finland
Extracorporeal dialysis
9.6
6.8
13
14
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
6.8
81
448
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
6.7
37
146
S01EC03
ATC
dorzolamide; ophthalmic
7.0
6.6
15
22
H50.31
ICD-10 Finland
Intermittent exotropia
14.6
6.4
10
7
L04AA06
ATC
mycophenolic acid; systemic
6.7
6.4
15
23
R06.0
ICD-10 Finland
Dyspnoea
1.8
6.4
124
802
H35.36
ICD-10 Finland
Macular cyst
11.3
6.3
11
10
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
18.4
6.3
9
5
C03CA01
ATC
furosemide; systemic
1.7
6.3
146
994
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
27.1
6.2
8
*
N02BE01
ATC
paracetamol; systemic, rectal
2.4
6.2
360
3186
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.5
6.2
17
32
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
4.0
6.0
17
44
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.6
6.0
34
136
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
184
1078
2.32
14.86
2.4
2.2
144.04
272.62
u/l
1.27
171
1018
261
1817
2.27
13.35
11.0
6.8
1.22
1.21
mmol/l
0.78
228
1565
241
1645
2.18
12.66
9.0
6.0
1.22
1.21
mmol/l
0.27
214
1510
85
389
2.51
11.61
10.7
7.0
—
—
—
0
0
281
2095
2.17
11.03
5.9
4.9
6.88
6.74
mmol/l
0.51
270
1970
54
203
2.92
10.80
2.6
2.5
21.80
21.77
au/ml
—
5
14
331
2653
2.49
10.69
10.0
7.9
80.34
79.15
u/l
0.19
307
2499
237
1683
2.01
10.30
19.8
15.3
1.35
1.26
inr
1.14
194
1402
20
38
5.49
10.22
1.1
1.1
—
—
—
0
0
204
1409
1.92
9.25
5.4
4.1
76.00
76.45
ng/l
0.00
162
1066
363
3104
2.98
9.13
7.0
5.4
2.04
1.96
mu/l
0.56
323
2852
84
430
2.21
8.72
6.1
4.9
36.73
32.39
%
2.10
56
269
296
2347
2.03
8.56
7.1
4.9
911.62
3899.66
e6/l
—
8
50
137
851
1.93
8.37
2.7
2.3
—
—
—
0
0
250
1898
1.86
7.95
5.8
6.2
11.06
12.11
umol/l
0.64
235
1798
218
1588
1.83
7.92
6.6
4.6
35.75
35.32
g/l
0.49
193
1493
111
653
1.97
7.89
1.8
1.7
1106.69
1203.16
nmol/l
0.55
75
500
275
2162
1.89
7.70
4.0
3.2
49.04
48.45
u/l
0.03
250
2028
164
1114
1.80
7.36
1.8
1.7
19.22
20.68
nmol/l
0.51
128
944
49
213
2.48
7.35
6.4
3.7
1.71
1.79
mmol/l
0.04
42
160
37
141
2.79
7.20
2.0
1.9
—
—
—
0
0
379
3399
3.54
7.18
29.3
20.0
4.00
3.98
mmol/l
1.05
370
3321
383
3459
4.04
7.12
16.2
12.0
24.11
24.91
u/l
0.53
363
3347
314
2611
1.97
7.00
5.5
4.3
15.15
14.91
pmol/l
0.76
278
2373
385
3498
4.33
6.89
31.1
22.0
84.72
77.72
umol/l
1.75
380
3446
175
1229
1.76
6.89
3.7
3.3
2.36
2.36
mmol/l
0.05
150
1117
378
3397
3.36
6.88
29.1
19.8
139.51
139.62
mmol/l
0.38
369
3323
172
1203
1.76
6.86
4.2
3.3
6.94
7.32
mmol/l
0.44
137
1004
50
227
2.38
6.82
1.7
1.9
—
—
—
0
0
35
134
2.77
6.75
1.7
1.8
—
—
—
0
0
214
1601
1.73
6.65
3.0
2.4
74.36
77.85
nmol/l
1.10
183
1435
254
1999
1.75
6.53
9.6
9.5
4.40
4.17
e9/l
0.55
213
1751
217
1637
1.72
6.48
2.4
2.2
98.72
95.79
pmol/l
0.38
115
849
12
13
9.48
6.33
1.2
1.2
—
—
—
0
0
350
3060
2.21
6.30
5.3
4.2
1.27
1.26
mmol/l
0.20
305
2795
30
110
2.87
6.27
1.8
1.4
1.30
0.15
iu/ml
—
8
23
305
2547
1.85
6.25
6.3
4.3
12.58
13.16
mm/h
0.28
275
2359
158
1102
1.72
6.22
4.7
2.6
105.71
64.00
u/l
0.66
143
1024
140
944
1.75
6.22
2.9
2.3
3.23
3.10
mg/l
0.20
115
820
361
3201
2.41
6.20
6.3
5.0
1.49
1.47
mmol/l
0.20
325
2954
16
39
4.23
6.14
1.3
1.1
—
—
—
0
0
167
1188
1.70
6.08
5.0
4.1
10.81
9.06
mg/mmol
0.18
111
734
353
3108
2.23
6.05
9.3
6.6
41.54
39.59
mmol/mol
2.60
319
2918
360
3197
2.35
6.00
7.2
5.2
6.12
5.98
mmol/l
1.03
312
2935
369
3313
2.61
5.99
23.9
16.8
24.84
23.99
mg/l
0.17
321
2759
366
3276
2.50
5.95
7.0
5.9
2.56
2.65
mmol/l
1.04
333
3028
361
3217
2.35
5.84
6.2
5.1
4.47
4.56
mmol/l
0.86
327
2984
9
7
13.11
5.60
1.1
1.4
—
—
—
0
0
59
311
2.05
5.58
2.5
2.9
66.58
66.43
g/l
0.05
50
286
386
3573
3.90
5.43
36.1
25.4
242.94
246.88
e9/l
0.60
378
3503
20
63
3.29
5.39
7.6
6.4
114.33
453.91
iu/ml
—
6
11
11
14
8.04
5.38
3.7
4.1
537.55
803.07
u/ml
0.54
11
14
386
3576
3.87
5.36
36.1
25.4
4.40
4.43
e12/l
0.60
376
3493
386
3576
3.87
5.36
36.4
25.7
39.82
39.90
%
0.10
381
3530
386
3576
3.87
5.36
35.9
25.3
91.75
91.32
fl
1.14
381
3533
162
1173
1.64
5.34
4.8
3.4
1800.53
1523.53
ng/l
0.41
138
1000
386
3579
3.83
5.29
36.2
25.5
133.04
133.45
g/l
0.22
381
3532
13
22
6.07
5.26
1.4
1.0
—
—
—
0
0
56
297
2.03
5.21
14.6
6.5
11.37
9.71
mmol/l
0.98
51
282
354
3177
2.05
4.86
20.8
16.5
76.62
78.41
ml/min/173m2
0.76
329
2946
49
263
1.98
4.41
1.4
1.6
—
—
—
0
0
206
1644
1.53
4.15
3.0
2.7
—
—
estimate
—
0
0
10
17
6.00
4.15
1.2
1.1
—
—
—
0
0
52
292
1.90
4.11
3.2
2.6
7.45
7.66
ug/l
0.02
39
261
13
31
4.30
4.05
1.1
1.1
—
—
—
0
0
126
920
1.54
3.75
4.2
2.8
346.35
347.67
umol/l
0.05
107
802
14
39
3.68
3.73
1.4
1.1
—
—
—
0
0
111
790
1.56
3.70
1.5
1.7
417.46
441.87
pmol/l
0.37
89
653
232
1933
1.48
3.58
6.1
4.3
0.00
0.73
estimate
0.50
29
415
48
277
1.83
3.50
7.8
3.2
106.42
78.57
ng/l
1.14
43
240
94
653
1.58
3.46
1.9
1.9
—
—
—
0
0
14
47
3.05
3.44
1.4
1.3
1.67
3.90
u/ml
—
6
21
19
76
2.58
3.43
3.2
1.1
16.31
3.81
e6/l
0.69
13
59
169
1336
1.46
3.35
5.9
3.3
—
—
—
0
0
227
1899
1.46
3.33
5.8
4.2
0.00
0.00
estimate
-0.00
29
426
61
385
1.69
3.28
4.8
3.5
1.92
2.05
mmol/l
0.08
53
322
11
29
3.87
3.21
5.1
2.6
—
—
—
0
0
55
340
1.72
3.19
1.8
1.6
1.52
1.55
%
0.12
48
294
6
8
7.59
3.06
1.3
1.4
—
—
—
0
0
13
45
2.95
3.05
1.4
1.2
1.20
1.75
u/ml
—
5
16
227
1919
1.43
3.03
6.0
4.2
0.00
3.68
estimate
0.50
32
441
113
841
1.48
2.99
7.6
4.4
1.02
1.02
kg/l
0.40
78
564
12
37
3.31
2.96
1.3
1.4
—
—
—
0
0
8
17
4.78
2.93
1.0
1.0
1358.00
1425.94
miu/ml
—
8
17
22
102
2.22
2.92
1.5
1.3
328.41
317.90
ug/g
—
10
57
9
22
4.16
2.90
2.6
2.2
216.67
165.94
e6/l
—
9
17
7
13
5.46
2.88
1.3
2.0
—
—
—
0
0
7
13
5.46
2.88
1.3
2.0
—
—
—
0
0
8
18
4.51
2.81
1.4
1.1
—
—
—
0
0
12
39
3.14
2.79
1.2
1.5
—
—
—
0
0
5
6
8.42
2.75
1.2
1.5
—
—
—
0
0
53
338
1.66
2.75
2.3
2.3
0.21
0.21
g/l
0.11
44
317
7
14
5.07
2.74
1.3
1.9
—
—
—
0
0
12
40
3.06
2.71
1.2
1.5
—
—
—
0
0
12
40
3.06
2.71
1.2
1.5
—
—
—
0
0
23
113
2.10
2.67
2.6
3.4
1.70
1.54
mg/l
0.38
23
101
139
1096
1.41
2.66
6.6
4.3
0.00
0.00
estimate
0.50
29
401
12
41
2.99
2.64
1.2
1.5
—
—
—
0
0
12
41
2.99
2.64
1.3
1.7
—
—
—
0
0
144
1144
1.41
2.64
3.4
2.9
32.01
32.60
u/l
0.09
131
1079
31
172
1.87
2.59
1.2
1.0
—
—
—
0
0
12
42
2.91
2.57
1.2
1.5
—
—
—
0
0
12
42
2.91
2.57
1.2
1.5
—
—
—
0
0
14
56
2.55
2.56
4.0
2.8
—
947.40
—
0
5
6
11
5.52
2.55
2.8
1.6
—
—
—
0
0
6
11
5.52
2.55
1.3
1.1
—
—
—
0
0
6
11
5.52
2.55
1.3
1.1
—
—
—
0
0
104
784
1.44
2.54
1.8
1.7
1.07
1.40
mg/l
0.80
79
630
7
16
4.43
2.48
1.1
1.5
—
—
—
0
0
12
45
2.72
2.47
1.2
1.2
—
—
—
0
0
6
12
5.06
2.41
1.3
1.3
—
—
—
0
0
6
12
5.06
2.41
1.2
1.2
—
—
—
0
0
14
58
2.47
2.39
3.1
1.3
151.40
155.74
au/ml
—
5
18
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
22
3.69
2.37
1.1
1.2
—
—
—
0
0
8
23
3.53
2.28
2.5
2.2
346.13
522.00
e6/l
—
8
16
6
13
4.67
2.28
1.0
1.4
—
—
—
0
0
6
13
4.67
2.28
1.0
1.4
—
—
—
0
0
15
66
2.32
2.27
1.0
1.3
—
144.00
—
0
5
15
66
2.32
2.27
1.0
1.3
—
—
—
0
0
190
1612
1.34
2.22
4.0
3.0
132.96
119.91
ug/l
0.38
166
1493
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
102
2.01
2.14
2.2
2.2
0.28
0.35
iu/ml
0.41
11
55
14
62
2.30
2.10
1.6
1.3
—
—
—
0
0
7
20
3.54
2.06
1.3
1.7
—
—
—
0
0
7
20
3.54
2.06
1.3
1.7
—
—
—
0
0
7
20
3.54
2.06
1.3
1.7
—
—
—
0
0
7
20
3.54
2.06
1.3
1.7
—
—
—
0
0
102
794
1.38
2.05
1.4
1.3
0.72
1.56
u/ml
1.66
28
211
50
340
1.54
2.02
2.2
1.8
344.83
390.80
nmol/l
1.00
41
319
7
21
3.37
1.97
1.4
1.1
—
—
—
0
0
33
204
1.67
1.96
1.7
1.4
—
—
—
0
0
10
39
2.60
1.95
1.4
1.7
—
—
—
0
0
6
17
3.57
1.84
1.0
1.5
—
—
—
0
0
6
17
3.57
1.84
1.0
1.5
—
—
—
0
0
5
12
4.21
1.83
1.2
1.2
—
—
—
0
0
8
29
2.79
1.80
1.3
1.2
—
—
—
0
0
78
593
1.39
1.80
3.2
3.1
0.82
0.81
mmol/l
0.24
71
563
32
202
1.64
1.77
1.1
1.2
171.21
136.31
u/ml
0.16
13
85
9
36
2.53
1.75
1.2
1.6
—
—
—
0
0
9
36
2.53
1.75
1.2
1.6
—
—
—
0
0
9
36
2.53
1.75
1.2
1.6
—
—
—
0
0
10
41
2.48
1.65
1.7
1.3
—
—
—
0
0
5
14
3.60
1.62
2.2
1.2
—
—
—
0
0
5
14
3.60
1.62
1.2
1.6
36.44
41.90
g/l
—
5
14
18
100
1.84
1.55
1.1
1.4
296.33
299.06
miu/ml
—
6
45
18
100
1.84
1.55
1.2
1.3
—
—
—
0
0
59
439
1.40
1.55
4.1
4.5
263.88
253.47
u/l
0.09
52
414
21
123
1.75
1.54
1.1
1.3
—
—
—
0
0
6
21
2.88
1.51
1.7
1.7
—
—
—
0
0
121
1012
1.28
1.45
6.6
5.5
3.17
2.96
ug/l
0.08
110
903
167
1453
1.26
1.44
6.2
4.3
0.00
0.04
estimate
1.95
27
361
94
761
1.31
1.44
3.0
2.9
2.45
2.46
mmol/l
0.70
85
678
19
111
1.75
1.41
1.5
1.4
—
—
—
0
0
76
599
1.33
1.40
3.3
3.2
1.06
0.82
ug/l
0.39
45
400
44
318
1.43
1.36
2.9
2.5
0.58
0.55
e6/l
0.02
44
300
5
17
2.96
1.36
1.2
1.2
—
—
—
0
0
5
17
2.96
1.36
1.0
1.1
—
—
—
0
0
9
43
2.12
1.31
2.2
2.1
10.00
10.74
mmol/l
—
9
43
57
435
1.36
1.30
4.6
6.5
0.76
1.22
mmol/l
0.42
44
366
15
84
1.82
1.29
2.0
2.8
126.09
66.11
ug/min
—
7
48
215
1944
1.23
1.26
3.1
2.9
—
—
—
0
0
21
131
1.64
1.26
1.2
2.9
0.09
0.56
g/l
1.22
15
117
97
803
1.28
1.25
5.6
4.7
22.34
21.76
%
0.13
53
403
81
665
1.27
1.12
3.4
2.8
1.20
1.05
e6/l
0.17
48
356
76
619
1.28
1.12
4.1
2.4
12.45
12.69
umol/l
0.10
71
578
16
96
1.69
1.12
1.3
1.2
—
—
—
0
0
34
245
1.42
1.10
6.4
5.9
24.43
24.40
mmol/l
0.02
34
235
8
41
1.97
1.09
1.3
1.3
—
—
—
0
0
23
153
1.53
1.09
1.9
1.8
2.90
2.97
ug/l
0.01
17
134
53
413
1.33
1.08
2.6
2.7
13.87
8.39
umol/l
0.42
47
357
20
130
1.57
1.05
1.3
1.2
0.27
2.79
u/ml
—
6
10
23
155
1.51
1.03
1.3
2.5
7.47
7.52
g/l
0.05
18
144
23
155
1.51
1.03
1.3
2.5
4.09
4.30
g/l
0.41
18
144
23
155
1.51
1.03
1.2
2.5
3.49
3.78
g/l
0.36
18
144
15
91
1.67
1.02
3.4
3.1
1.43
2.04
index
—
7
53
16
99
1.64
1.01
1.3
1.8
—
—
—
0
0
9
157
0.56
1.00
4.0
2.8
56.56
1892.45
u/ml
—
9
136
25
173
1.47
1.00
1.9
2.1
1.65
1.51
g/l
0.34
20
157
67
547
1.27
0.98
4.3
2.4
21.64
22.26
%
0.14
62
513
46
359
1.32
0.94
4.8
7.1
122.59
121.30
g/l
0.20
46
352
21
144
1.48
0.89
1.3
2.6
2.83
2.99
g/l
0.32
16
133
6
30
2.01
0.87
5.3
3.1
1039.00
1058.77
mg
—
6
30
6
30
2.01
0.87
1.5
1.2
—
—
—
0
0
12
72
1.69
0.86
1.1
1.1
—
12.81
—
0
7
6
31
1.95
0.84
1.5
1.2
—
—
—
0
0
59
484
1.26
0.84
1.7
1.9
—
—
—
0
0
74
623
1.23
0.84
1.3
1.3
18.92
35.70
iu/ml
1.18
15
207
6
32
1.89
0.82
1.5
1.2
—
—
—
0
0
6
32
1.89
0.82
1.5
1.2
—
—
—
0
0
6
32
1.89
0.82
1.2
1.4
—
53.33
—
0
6
121
1074
1.18
0.79
4.1
3.2
0.26
0.55
e6/l
1.68
95
784
6
33
1.83
0.79
2.0
3.6
19.75
66.54
u/ml
—
6
33
35
270
1.32
0.79
3.5
3.0
304.60
233.29
ng/l
0.41
29
246
0
26
0.00
0.78
0.0
2.0
—
13.45
—
0
26
35
272
1.31
0.76
2.3
2.7
51.85
63.77
ml/min/173m2
1.94
20
118
16
230
0.68
0.74
1.2
1.2
164.88
267.34
u/ml
0.44
16
216
69
585
1.22
0.74
4.2
2.4
2.25
2.31
g/l
0.48
64
539
22
159
1.41
0.74
1.4
1.5
0.48
0.31
mg/l
—
5
63
5
26
1.93
0.71
2.4
1.2
121.40
92.50
pmol/l
—
5
26
21
152
1.40
0.70
1.5
1.8
2.50
8.15
iu/ml
—
5
43
55
461
1.22
0.67
1.7
2.0
—
—
—
0
0
12
78
1.56
0.66
1.3
1.3
—
—
—
0
0
151
1383
1.15
0.65
1.9
1.9
1.33
1.31
mmol/l
0.07
130
1136
42
344
1.25
0.63
5.5
2.1
27.28
33.83
u/l
1.08
36
284
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
6
35
1.72
0.58
1.5
1.2
—
—
—
0
0
33
266
1.26
0.57
1.6
1.4
—
—
—
0
0
6
36
1.68
0.57
1.0
1.3
407.67
566.34
u/l
—
6
36
6
36
1.68
0.57
1.0
1.3
—
—
—
0
0
6
39
1.55
0.53
1.8
1.2
—
—
—
0
0
17
127
1.35
0.50
2.1
3.0
—
—
—
0
0
14
103
1.37
0.46
1.6
1.2
—
—
—
0
0
14
104
1.36
0.43
1.6
1.2
—
—
—
0
0
5
32
1.57
0.42
1.0
1.4
—
—
—
0
0
10
70
1.44
0.42
1.3
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
6.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
9.50
—
0
16
11
79
1.40
0.41
2.0
1.5
—
—
—
0
0
17
132
1.30
0.41
1.2
2.6
12.55
9.80
g/l
0.46
12
120
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
2.2
—
76.76
—
0
18
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
9
68
1.33
0.38
1.0
1.5
—
—
—
0
0
14
107
1.32
0.37
1.3
1.5
38.74
25.39
iu/l
—
8
90
68
615
1.13
0.36
3.5
3.0
1.59
2.24
e6/l
0.76
34
308
43
378
1.15
0.35
3.3
3.7
—
—
—
0
0
6
44
1.37
0.34
1.2
1.2
—
—
—
0
0
76
695
1.12
0.34
5.9
4.2
34.13
239.35
ng/l
2.79
57
571
13
101
1.30
0.32
1.4
1.4
—
—
—
0
0
35
399
0.87
0.31
2.4
4.3
3.34
17.81
ug/l
0.79
29
340
7
54
1.30
0.30
1.0
1.5
—
—
—
0
0
62
565
1.12
0.30
1.2
1.3
1.31
10.41
u/ml
2.76
18
209
8
62
1.30
0.28
2.6
1.9
160.25
217.47
pmol/l
—
8
57
20
169
1.19
0.26
1.6
1.3
—
—
—
0
0
6
85
0.70
0.24
1.2
1.2
—
40.90
—
0
12
31
347
0.88
0.23
2.3
2.3
—
—
—
0
0
7
94
0.74
0.22
1.0
1.1
1.44
1.55
g/l
—
7
94
7
95
0.73
0.22
1.0
1.1
0.91
0.88
g/l
—
7
95
5
41
1.22
0.22
1.0
1.1
—
2.48
—
0
17
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
11
89
1.24
0.21
2.1
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
309.67
—
0
6
0
14
0.00
0.20
0.0
1.1
—
8.11
—
0
14
6
51
1.18
0.19
1.2
1.3
0.73
38.36
nmol/l
—
6
45
18
158
1.15
0.16
2.2
2.1
—
—
—
0
0
6
76
0.79
0.15
1.5
4.3
7.33
427.26
u/ml
—
6
71
6
76
0.79
0.15
1.0
1.4
—
—
—
0
0
13
112
1.17
0.14
1.3
1.3
—
1.58
—
0
5
13
113
1.16
0.13
1.2
1.4
—
—
—
0
0
11
96
1.15
0.10
1.9
1.9
—
—
—
0
0
5
46
1.09
0.09
4.8
4.2
—
—
—
0
0
6
54
1.11
0.09
1.5
1.7
—
—
—
0
0
5
65
0.77
0.08
1.2
1.8
—
—
—
0
0
108
1055
1.03
0.08
4.7
3.7
0.00
0.08
estimate
0.60
28
349
10
88
1.14
0.08
1.0
1.4
—
—
—
0
0
9
87
1.04
0.07
1.2
1.3
—
—
—
0
0
10
89
1.13
0.07
1.2
1.4
—
—
—
0
0
20
187
1.07
0.06
2.6
2.2
—
—
—
0
0
29
302
0.96
0.04
3.6
4.2
1.24
1.23
mmol/l
0.64
24
262
56
574
0.97
0.04
1.6
1.5
—
—
—
0
0
30
310
0.97
0.03
2.2
2.1
—
—
—
0
0
20
194
1.03
0.00
4.7
7.9
16.07
15.95
%
0.06
20
186
49
488
1.00
0.00
1.8
1.4
—
—
—
0
0
12
115
1.04
0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.18
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
7.36
—
0
8
7
70
1.00
-0.00
8.6
3.2
10.67
9.50
pmol/l
—
7
70
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
78
0.90
-0.00
1.3
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
7
74
0.94
-0.00
1.6
2.5
18.20
15.87
%
—
7
74
0
6
0.00
-0.00
0.0
1.0
—
68.98
—
0
6
8
83
0.96
-0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
78
0.90
-0.00
1.3
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_SEVVISIMPMONOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPMONOC | 1.039 [0.83, 1.3] | 0.732 |
| Birth year | 0.998 [0.99, 1.01] | 0.58 |
During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 1136 females with H7_SEVVISIMPMONOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPMONOC | 1.545 [1.1, 2.16] | 0.011 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 954 males with H7_SEVVISIMPMONOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_SEVVISIMPMONOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.283% |
| 5 | 0.654% | 1.82% |
| 10 | 1.606% | 4.232% |
| 15 | 3.138% | 8.11% |
| 20 | 5.713% | 14.077% |
Relationships between endpoints
↥Index endpoint: H7_SEVVISIMPMONOC – Severe visual impairment, monocular
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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