eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Other and unspecified postprocedural disorders of eye and adnexa
DOID EFO Endpoint Browser PheWeb
H7_POSTOPEYENAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
103 |
4. Check minimum number of eventsNone |
103 |
5. Include endpointsNone |
103 |
6. Filter based on genotype QC (FinnGen only) |
86 |
Control definitions (FinnGen only)
- Control exclude
- H7_EYEPOSTOP
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified postprocedural disorders of eye and adnexa
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of eye and adnexa, not elsewhere classified
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 541 | 282 | 257 |
| Only index persons | 456 | 238 | 218 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 71.21 | 72.30 | 70.00 |
| Only index persons | 69.97 | 70.56 | 69.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 86 | 46 | 40 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 72.95 | 73.92 | 71.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 93
- Matched controls
- 930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H59.9
ICD-10 Finland
Postprocedural disorder of eye and adnexa, unspecified
1027.1
57.0
50
*
H59.8
ICD-10 Finland
Other postprocedural disorders of eye and adnexa
+∞
49.5
43
*
WX140
NOMESCO Finland
Parabulbar anesthesy
20.3
39.8
36
28
Z96.1
ICD-10 Finland
Presence of intraocular lens
11.2
31.7
58
120
WX100
NOMESCO Finland
Conjunctival surface anesthesia
8.9
25.5
49
103
CJE99
NOMESCO Finland
Other extracapsular cataract operation using phakoemulsification technique
+∞
19.4
18
*
S01ED51
ATC
timolol, combinations; ophthalmic
8.3
18.9
31
53
CKD60
NOMESCO Finland
Anterior vitrectomy
44.5
17.6
21
6
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
33.3
16.5
21
8
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.9
14.5
23
37
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
+∞
13.9
13
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
29.2
13.0
17
7
CJW99
NOMESCO Finland
Other operation on lens
149.3
12.8
13
*
H25.8
ICD-10 Finland
Other senile cataract
5.0
11.8
34
96
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.9
11.6
67
321
H33.0
ICD-10 Finland
Retinal detachment with retinal break
12.8
10.3
18
17
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.0
9.7
58
274
CKD40
NOMESCO Finland
Endophotocoagulation of retina
22.6
8.7
12
6
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
+∞
8.5
8
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
49.3
7.9
9
*
S01EE01
ATC
latanoprost; ophthalmic
4.9
7.7
19
46
H27.0
ICD-10 Finland
Aphakia
86.7
7.5
8
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
10.6
7.1
13
14
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
13.6
6.8
11
9
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
15.8
6.6
10
7
CKD15
NOMESCO Finland
Injection of vitreous substitute
74.8
6.5
7
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
104
5.02
12.24
5.2
5.1
30.10
32.60
%
0.67
21
60
16
31
6.01
6.04
1.4
1.8
—
—
—
0
0
15
35
4.90
4.90
1.3
1.9
—
—
—
0
0
65
465
2.32
3.42
5.1
7.2
1.23
1.21
mmol/l
2.43
57
397
59
413
2.17
3.17
4.8
6.6
1.24
1.21
mmol/l
2.46
50
383
59
417
2.13
3.05
2.3
2.2
87.56
96.58
pmol/l
0.61
25
201
66
491
2.19
2.93
3.9
3.3
78.36
57.47
u/l
0.42
56
456
34
202
2.08
2.73
2.3
2.7
—
—
—
0
0
84
732
2.52
2.19
6.0
5.4
2.06
1.96
mu/l
0.31
71
653
75
616
2.12
2.18
5.9
4.9
12.01
13.57
mm/h
0.53
67
562
20
108
2.09
2.01
4.1
9.6
—
—
—
0
0
51
378
1.77
1.95
2.6
2.5
78.46
78.77
nmol/l
0.02
44
335
84
746
2.30
1.76
5.8
5.5
1.54
1.47
mmol/l
0.57
69
671
86
770
2.55
1.76
18.6
19.5
21.28
24.50
mg/l
0.57
80
666
82
720
2.17
1.63
4.8
4.6
1.20
1.26
mmol/l
0.36
64
644
86
778
2.40
1.62
6.4
6.4
2.55
2.56
mmol/l
0.02
70
700
84
752
2.21
1.62
5.7
5.5
4.52
4.49
mmol/l
0.10
68
680
40
288
1.68
1.62
2.6
2.4
70.25
56.43
u/l
1.49
35
264
60
482
1.69
1.59
5.6
10.5
4.46
4.38
e9/l
0.10
52
427
75
644
1.85
1.53
8.0
8.6
82.12
82.46
u/l
0.02
69
603
24
155
1.74
1.41
1.4
1.3
58.40
31.98
iu/ml
—
5
46
26
172
1.71
1.41
1.7
2.0
—
—
—
0
0
83
742
2.10
1.41
18.5
19.5
74.18
74.71
ml/min/173m2
0.09
75
698
41
306
1.61
1.40
5.0
4.1
13.68
11.46
mg/mmol
0.07
25
186
33
234
1.64
1.38
2.3
3.1
328.93
353.82
umol/l
0.84
27
193
50
393
1.59
1.37
2.5
2.9
—
—
estimate
—
0
0
39
293
1.57
1.27
2.0
1.8
21.70
22.08
nmol/l
0.05
27
233
12
65
1.97
1.20
1.3
1.9
—
—
—
0
0
83
754
1.94
1.15
6.4
5.8
6.04
6.05
mmol/l
0.05
69
674
48
385
1.51
1.13
4.6
4.4
31.50
47.40
ng/l
0.74
35
301
82
743
1.88
1.13
8.4
7.5
42.02
40.78
mmol/mol
0.30
71
682
43
338
1.51
1.11
3.1
3.6
1423.26
1643.51
ng/l
0.17
34
279
0
29
0.00
0.99
0.0
1.4
—
—
—
0
0
33
251
1.49
0.98
2.1
2.3
2.85
2.94
mg/l
0.10
25
219
26
192
1.49
0.88
1.6
1.8
901.48
1269.39
nmol/l
1.83
18
142
9
141
0.60
0.77
4.4
7.4
105.89
104.35
mmol/l
—
9
141
13
84
1.64
0.77
2.6
2.8
0.20
0.22
g/l
0.46
13
76
10
61
1.72
0.72
1.2
1.6
—
—
—
0
0
67
610
1.35
0.59
4.3
4.2
15.59
15.10
pmol/l
0.90
55
540
6
38
1.62
0.55
1.3
2.1
57.00
44.50
u/l
—
6
32
54
598
0.77
0.55
23.7
26.0
331.19
330.87
g/l
0.08
54
598
7
48
1.49
0.48
2.6
2.9
—
—
—
0
0
14
104
1.41
0.46
1.3
1.5
—
—
—
0
0
43
379
1.25
0.44
2.5
3.0
131.51
129.66
ug/l
0.02
36
348
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
14
177
0.75
0.37
4.1
3.1
0.57
0.81
ug/l
—
6
113
25
214
1.23
0.32
2.0
1.9
319.90
468.92
pmol/l
3.25
20
175
7
53
1.35
0.31
2.4
3.1
—
—
—
0
0
15
126
1.23
0.22
1.7
2.0
—
—
—
0
0
5
42
1.20
0.22
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
262.29
—
0
7
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
21
236
0.86
0.19
5.1
4.9
23.09
22.54
%
—
9
121
43
403
1.12
0.18
2.8
2.9
—
—
—
0
0
7
89
0.77
0.15
1.1
1.6
—
—
—
0
0
18
201
0.87
0.15
4.8
4.4
1.01
1.02
kg/l
0.58
12
127
10
84
1.21
0.14
1.7
1.3
—
—
—
0
0
33
312
1.09
0.10
2.0
3.4
2.40
2.35
mmol/l
1.16
22
281
6
55
1.10
0.09
1.5
1.4
—
—
—
0
0
11
123
0.88
0.08
1.6
2.1
—
—
—
0
0
40
414
0.94
0.06
3.6
4.6
36.43
34.74
g/l
0.88
35
389
31
303
1.03
0.01
1.6
2.0
1.19
1.34
mmol/l
0.77
25
249
12
118
1.02
0.00
3.8
7.5
-2.72
1.01
mmol/l
—
6
99
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
5.72
—
0
5
0
5
0.00
0.00
0.0
11.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
94.60
—
0
5
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
48.95
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_POSTOPEYENAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_POSTOPEYENAS | 1.186 [0.87, 1.61] | 0.277 |
| Birth year | 0.998 [0.99, 1.01] | 0.592 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 221 females with H7_POSTOPEYENAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_POSTOPEYENAS | 1.221 [0.89, 1.68] | 0.222 |
| Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 207 males with H7_POSTOPEYENAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_POSTOPEYENAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.158% | 0.267% |
| 5 | 0.729% | 1.541% |
| 10 | 1.938% | 3.612% |
| 15 | 3.787% | 6.642% |
| 20 | 6.666% | 11.455% |
Relationships between endpoints
↥Index endpoint: H7_POSTOPEYENAS – Other and unspecified postprocedural disorders of eye and adnexa
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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