eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Postprocedural disorders of eye and adnexa, not elsewhere classified
DOID EFO Endpoint Browser PheWeb
H7_EYEPOSTOP
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
139 |
4. Check minimum number of eventsNone |
139 |
5. Include endpoints |
139 |
6. Filter based on genotype QC (FinnGen only) |
117 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H55-H59
- Name in latin
- Morbositates oculi et organorum accessoriorum post interventiones non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Postprocedural disorders of eye and adnexa, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 873 | 487 | 378 |
| Only index persons | 737 | 418 | 319 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 72.77 | 74.62 | 70.31 |
| Only index persons | 71.58 | 73.40 | 69.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 117 | 63 | 54 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 73.06 | 74.46 | 71.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 126
- Matched controls
- 1260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H59.9
ICD-10 Finland
Postprocedural disorder of eye and adnexa, unspecified
805.7
54.9
50
*
H59.8
ICD-10 Finland
Other postprocedural disorders of eye and adnexa
+∞
48.0
43
*
WX140
NOMESCO Finland
Parabulbar anesthesy
17.9
47.2
45
38
Z96.1
ICD-10 Finland
Presence of intraocular lens
11.5
43.9
80
165
H59.0
ICD-10 Finland
Keratopathy (bullous aphakic) following cataract surgery
+∞
35.0
32
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
7.1
26.7
60
143
S01ED51
ATC
timolol, combinations; ophthalmic
8.6
25.4
40
65
CKD60
NOMESCO Finland
Anterior vitrectomy
44.0
20.7
25
7
CJE99
NOMESCO Finland
Other extracapsular cataract operation using phakoemulsification technique
+∞
20.4
19
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
32.5
18.6
24
9
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.4
16.4
27
45
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
33.5
15.7
20
7
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.9
15.2
92
450
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
+∞
14.9
14
*
CJW99
NOMESCO Finland
Other operation on lens
156.1
13.7
14
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.8
12.1
78
378
H25.8
ICD-10 Finland
Other senile cataract
4.0
10.9
39
126
H33.0
ICD-10 Finland
Retinal detachment with retinal break
10.4
9.9
19
21
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
+∞
9.5
9
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
10.2
8.9
17
19
H27.0
ICD-10 Finland
Aphakia
96.2
8.5
9
*
S01EE01
ATC
latanoprost; ophthalmic
4.4
8.2
23
61
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
5.0
8.2
19
43
CKD20
NOMESCO Finland
Removal of vitreous body substitute
48.0
7.8
9
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
14.6
7.6
12
9
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
11.9
7.5
13
12
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.6
7.3
27
88
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
6.9
77
462
S01EA05
ATC
brimonidine; ophthalmic
8.6
6.8
14
18
S01BC03
ATC
diclofenac; ophthalmic
15.4
6.5
10
7
CKD15
NOMESCO Finland
Injection of vitreous substitute
73.4
6.5
7
*
S01EA03
ATC
apraclonidine; ophthalmic
28.2
6.3
8
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
13.4
6.2
10
8
H25.1
ICD-10 Finland
Senile nuclear cataract
2.5
6.0
67
393
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
38
137
3.54
8.90
5.2
5.2
29.48
33.10
%
1.21
23
80
16
42
4.22
5.74
1.4
1.9
—
—
—
0
0
89
624
2.45
5.02
6.1
6.8
1.23
1.21
mmol/l
2.30
76
527
82
562
2.31
4.77
5.5
6.1
1.23
1.21
mmol/l
2.03
72
520
80
554
2.22
4.38
2.4
2.2
89.71
94.44
pmol/l
0.35
38
265
15
46
3.57
4.34
1.3
2.0
—
—
—
0
0
114
970
2.84
3.15
6.1
5.4
1.99
1.99
mu/l
0.00
99
868
105
863
2.30
3.11
8.4
8.4
80.88
83.13
u/l
0.20
99
810
117
1036
2.81
2.79
21.5
19.4
27.49
25.09
mg/l
0.29
110
885
84
650
1.88
2.77
3.8
3.3
68.96
55.99
u/l
0.32
73
607
101
834
2.06
2.70
5.7
4.7
11.60
14.24
mm/h
1.52
93
757
42
269
1.84
2.52
2.2
2.5
—
—
—
0
0
82
644
1.78
2.43
7.4
9.8
4.50
4.38
e9/l
0.18
74
562
37
230
1.86
2.42
1.6
2.0
—
—
—
0
0
111
962
2.29
2.42
4.8
4.7
1.26
1.26
mmol/l
0.05
92
859
113
998
2.28
2.15
5.9
5.5
1.49
1.47
mmol/l
0.24
98
897
53
380
1.68
2.09
2.5
2.4
64.83
55.22
u/l
1.12
48
349
113
1005
2.21
1.99
6.0
5.6
4.52
4.46
mmol/l
0.28
97
909
115
1037
2.25
1.83
6.8
6.5
2.52
2.54
mmol/l
0.09
99
934
66
514
1.60
1.81
2.8
2.5
80.51
77.46
nmol/l
0.29
58
450
113
1014
2.11
1.79
6.4
5.8
6.09
6.10
mmol/l
0.02
99
911
5
13
3.96
1.73
1.4
1.5
—
—
—
0
0
16
85
2.01
1.64
1.3
1.9
—
—
—
0
0
52
390
1.57
1.63
2.0
1.8
21.66
21.72
nmol/l
0.01
38
310
111
1000
1.92
1.58
21.7
19.7
74.19
74.02
ml/min/173m2
0.03
103
941
66
528
1.52
1.52
2.6
2.9
—
—
estimate
—
0
0
93
809
1.57
1.40
4.5
4.2
15.34
15.18
pmol/l
0.26
80
718
66
541
1.46
1.28
4.7
4.6
30.06
43.44
ng/l
0.90
48
433
25
167
1.62
1.25
1.6
1.9
—
—
—
0
0
32
228
1.54
1.22
4.3
4.1
29.44
140.85
ng/l
1.59
27
194
58
469
1.44
1.19
3.0
3.7
1468.06
1688.66
ng/l
0.21
47
397
21
137
1.64
1.15
4.1
9.1
—
—
—
0
0
29
206
1.53
1.12
1.4
1.3
41.00
31.75
iu/ml
—
8
61
44
341
1.45
1.12
2.2
2.2
2.90
2.99
mg/l
0.11
36
293
53
427
1.42
1.09
5.0
4.2
12.11
10.10
mg/mmol
0.08
29
270
109
1003
1.64
1.09
8.9
7.7
42.13
40.98
mmol/mol
0.36
98
922
34
256
1.45
0.99
1.6
1.7
888.86
1271.96
nmol/l
2.79
25
190
15
93
1.70
0.99
2.1
1.5
—
—
—
0
0
9
156
0.54
0.96
4.2
3.7
—
—
—
0
0
39
311
1.37
0.82
2.2
3.0
338.63
358.21
umol/l
0.63
32
256
5
96
0.50
0.82
13.0
8.4
1.78
1.37
%
—
5
96
5
93
0.52
0.70
13.0
8.5
0.48
0.67
%
—
5
93
31
246
1.35
0.67
1.2
1.2
1.34
1.29
u/ml
—
5
56
7
111
0.61
0.61
1.1
1.5
—
—
—
0
0
20
155
1.35
0.51
5.4
6.7
-1.45
0.97
mmol/l
1.20
11
134
7
46
1.55
0.49
1.1
1.2
—
—
—
0
0
60
537
1.22
0.49
2.5
2.8
—
—
—
0
0
7
51
1.39
0.45
1.0
1.0
—
—
—
0
0
23
186
1.29
0.44
1.3
1.3
82.70
8.60
u/ml
—
5
71
5
31
1.64
0.43
1.2
1.5
1.20
1.10
g/l
—
5
31
5
31
1.64
0.43
1.2
1.4
0.27
0.22
g/l
—
5
31
0
15
0.00
0.41
0.0
3.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
20
161
1.29
0.40
1.5
2.1
—
—
—
0
0
43
483
0.83
0.39
4.4
4.6
0.00
0.00
estimate
—
9
116
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
27
227
1.24
0.39
1.4
2.4
2.39
2.24
g/l
0.94
22
204
31
359
0.82
0.39
4.2
4.1
0.00
0.00
estimate
—
9
115
5
78
0.63
0.37
2.4
2.8
1.04
1.15
%
—
5
78
6
45
1.35
0.34
1.3
1.3
—
—
—
0
0
7
54
1.31
0.31
2.6
2.8
—
—
—
0
0
56
516
1.15
0.30
2.5
2.8
119.98
138.10
ug/l
0.34
47
466
10
76
1.34
0.29
2.3
2.4
1.57
1.46
g/l
—
10
68
59
549
1.14
0.26
3.8
4.5
34.38
34.58
g/l
0.08
53
517
10
78
1.31
0.25
1.9
1.3
—
—
—
0
0
67
632
1.13
0.24
4.2
4.5
0.00
10.83
estimate
0.50
13
150
16
187
0.83
0.22
5.6
6.6
106.50
104.18
mmol/l
0.80
16
187
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
7.20
—
0
5
27
241
1.15
0.21
1.5
2.4
10.89
11.92
umol/l
0.32
22
217
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
45
417
1.12
0.21
1.9
3.2
2.39
2.35
mmol/l
1.22
34
374
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
76
793
0.90
0.20
26.5
25.9
330.89
330.92
g/l
0.01
76
793
0
14
0.00
0.20
0.0
1.0
—
211.20
—
0
5
29
320
0.88
0.20
5.5
4.9
21.41
21.76
%
0.04
13
170
66
627
1.11
0.19
4.3
4.5
0.00
0.00
estimate
-0.00
12
142
7
59
1.20
0.18
2.4
3.0
—
—
—
0
0
22
198
1.13
0.15
4.7
3.5
5.75
2.47
e6/l
0.30
16
97
44
418
1.08
0.12
2.0
2.0
1.17
1.34
mmol/l
1.22
35
332
66
638
1.07
0.11
4.4
4.6
0.00
0.03
estimate
0.50
13
132
5
43
1.17
0.10
3.2
2.7
—
—
—
0
0
36
379
0.93
0.10
4.6
4.5
0.00
0.00
estimate
-0.00
13
132
15
136
1.12
0.09
1.3
1.5
—
—
—
0
0
22
234
0.93
0.07
4.8
3.3
0.49
0.78
ug/l
2.32
13
152
35
363
0.95
0.05
4.8
3.5
0.86
0.42
e6/l
0.48
29
266
26
272
0.94
0.05
4.0
4.7
1.02
1.02
kg/l
0.32
19
176
22
209
1.06
0.05
4.5
3.3
13.51
1.17
e6/l
0.44
16
108
31
300
1.04
0.03
2.1
1.9
327.84
450.68
pmol/l
3.00
25
245
11
104
1.06
0.01
1.6
1.4
—
—
—
0
0
20
203
0.98
0.00
1.8
1.9
28.91
28.92
s
0.00
20
197
0
7
0.00
-0.00
0.0
1.7
—
48.95
—
0
7
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
99.14
—
0
7
8
84
0.95
-0.00
6.4
7.3
22.88
24.40
mmol/l
—
8
84
0
5
0.00
-0.00
0.0
1.0
—
15.94
—
0
5
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
10.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
95.83
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_EYEPOSTOP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYEPOSTOP | 1.239 [0.99, 1.54] | 0.057 |
| Birth year | 0.994 [0.99, 1.0] | 0.174 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 404 females with H7_EYEPOSTOP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYEPOSTOP | 1.275 [0.95, 1.71] | 0.102 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 311 males with H7_EYEPOSTOP died.
Mortality risk
Mortality risk for people of age
years, who have H7_EYEPOSTOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.248% |
| 5 | 0.685% | 1.393% |
| 10 | 1.707% | 3.671% |
| 15 | 3.339% | 6.617% |
| 20 | 5.871% | 11.493% |
Relationships between endpoints
↥Index endpoint: H7_EYEPOSTOP – Postprocedural disorders of eye and adnexa, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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