Chronic inflammatory disorders of orbit

H7_ORBITINFLAMCHRON

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H05.1 Hospital discharge: ICD-9 — 3761 Cause of death: ICD-10 — H05.1 Cause of death: ICD-9 — 3761 2 out of 7 registries used, show all original rules.	109
4. Check minimum number of events None	109
5. Include endpoints None	109
6. Filter based on genotype QC (FinnGen only)	100

Control definitions (FinnGen only)

Control exclude: H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H05
Name in latin: Inflammatio orbitae chronica

NAME	H7_ORBITINFLAMCHRON
CONTROL_EXCLUDE	H7_LIDLACRIMALORBIT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H051
HD_ICD_9	3761
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H051
COD_ICD_9	3761
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Chronic inflammatory disorders of orbit based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	733	362	363
Only index persons	668	330	338
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	50.37	54.07	46.47
Only index persons	49.07	52.64	45.59

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	100	53	47
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	53.23	50.66	56.12

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
104: Matched controls
1040

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H05.1

ICD-10 Finland

Chronic inflammatory disorders of orbit

+∞

134.7

Z01.0

ICD-10 Finland

Examination of eyes and vision

6.6

19.1

101

H05.2

ICD-10 Finland

Exophthalmic conditions

+∞

17.1

H02AB06

ATC

prednisolone; systemic

6.3

16.1

361

CAA30

NOMESCO Finland

Biopsy of orbit

+∞

14.9

CA1CG

NOMESCO Finland

Eye and orbita extensive MRI examination with high intensity magnet

173.3

14.9

H04.10

ICD-10 Finland

Dry eye syndrome

11.0

12.0

H57.1

ICD-10 Finland

Ocular pain

15.2

11.7

XCK00

NOMESCO Finland

Perimetry

11.0

10.6

H02.4

ICD-10 Finland

Ptosis of eyelid

+∞

10.6

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

3.7

9.9

288

H02AB07

ATC

prednisone; oral

4.6

9.3

D31.6

ICD-10 Finland

Benign neoplasm: Orbit, unspecified

+∞

8.4

3761A

ICD-9 Finland

Disorders of the orbit, Chronic inflammatory disorders of orbit

+∞

8.4

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic

3.4

8.4

218

H53.2

ICD-10 Finland

Diplopia

12.2

7.5

M60.9

ICD-10 Finland

Myositis, unspecified

86.0

7.5

H05.0

ICD-10 Finland

Acute inflammation of orbit

+∞

7.4

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.0

7.0

222

H01.0

ICD-10 Finland

Blepharitis

7.4

7.0

XCW99

NOMESCO Finland

Other investigative procedure of eye

4.6

7.0

Z03.80

ICD-10 Finland

Observation for other suspected diseases and conditions

19.5

6.4

CA1CM

NOMESCO Finland

Eye and orbita extensive MRI examination with 3 Tesla magnet

+∞

6.3

CA1DG

NOMESCO Finland

Eye and orbita very extensive MRI examination with high intensity magnet

+∞

6.3

H06.2*E05.9

ICD-10 Finland

Dysthyroid exophthalmos

+∞

6.3

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

9.5

6.2

S01ED51

ATC

timolol, combinations; ophthalmic

4.5

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

11.64

24.97

2.6

1.8

1.41

5.53

iu/l

—

(4062490) Immunoglobulin typing, IgG

37.01

16.88

1.9

1.3

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

7.91

15.83

1.9

1.5

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

33.40

13.45

1.8

2754.24

941.83

u/ml

—

(3005719) IgG [Mass/volume] in Serum or Plasma

4.77

10.48

2.1

2.0

10.73

10.02

g/l

0.32

(3037522) Nuclear Ab [Titer] in Serum

126

3.52

7.72

1.9

1.5

400.00

651.85

titre

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.45

6.44

2.2

1.6

—

(4035726) Immunohistochemistry procedure

3.45

5.74

1.5

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

513

2.93

5.60

18.3

10.3

5.05

4.11

e9/l

2.24

445

(42870588) Differential panel, method unspecified - Blood

306

2.59

5.37

11.1

5.4

—

(3001604) Monocytes [#/volume] in Blood

470

2.73

5.33

11.6

6.2

0.63

0.57

e9/l

1.16

401

(3006315) Basophils [#/volume] in Blood

471

2.72

5.29

11.6

6.2

0.04

e9/l

0.18

402

(3013115) Eosinophils [#/volume] in Blood

486

2.68

5.09

12.1

6.3

0.18

0.19

e9/l

0.20

427

(3019198) Lymphocytes [#/volume] in Blood

478

2.65

5.02

11.7

6.2

1.83

2.15

e9/l

0.72

423

(3018418) pH of Serum or Plasma

265

2.51

4.95

4.9

4.1

7.40

0.29

193

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.89

4.64

1.7

0.28

0.25

g/l

0.43

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.59

4.41

1.6

1.39

1.17

g/l

1.45

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

428

2.38

4.36

8.3

7.3

1.21

mmol/l

0.24

368

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

8.55

4.14

1.0

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

106

2.64

3.81

3.8

7.6

103.88

104.36

mmol/l

0.17

106

(3019832) Treponema pallidum Ab [Presence] in Serum

101

2.64

3.69

1.6

1.7

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

4.24

3.63

1.2

1.3

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

10.50

3.54

1.3

1.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.08

3.42

2.1

2.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

7.41

3.42

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

5.08

3.32

1.9

1.4

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

6.73

3.24

1.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.74

3.23

2.3

2.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

528

2.09

3.02

3.9

4.4

7.27

6.64

mmol/l

1.00

492

(3036603) Volume of Urine

10.41

3.01

1.4

4.2

3446.00

1661.00

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

150

2.19

2.88

2.7

1.9

—

(3012544) pH of Venous blood

2.59

2.83

3.9

3.3

7.39

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

8.67

2.78

1.0

1.2

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

8.67

2.78

1.0

1.2

—

(40768795) Lymph node Pathology biopsy report

6.29

2.73

1.0

1.1

—

(3021589) Normoblasts [#/volume] in Blood

421

1.93

2.71

15.5

11.6

0.00

0.01

e9/l

0.28

335

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

104

2.28

2.59

1.9

1.7

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.77

2.55

2.2

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

112

2.22

2.54

1.8

1.6

—

(36304419) Bacteria [Presence] in Urine

239

1.93

2.51

3.9

2.8

—

estimate

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

678

2.11

2.43

6.1

4.3

14.71

14.65

pmol/l

0.07

618

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.95

2.36

4.9

2.0

25.24

25.10

mmol/l

0.04

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

178

1.96

2.32

1.5

1.3

10.10

40.21

iu/ml

—

(3035350) Ketones [Presence] in Urine by Test strip

476

1.82

2.27

4.2

3.7

80.56

0.00

estimate

0.48

101

(3002582) Erythrocytes [#/volume] in Urine

290

1.82

2.25

4.0

3.0

21.97

44.24

e6/l

0.64

214

(3045142) Bone marrow Pathology biopsy report

5.77

2.24

1.4

1.2

—

(3026389) Candida sp identified in Specimen by Organism specific culture

5.77

2.24

1.0

1.2

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

3.52

2.23

1.6

1.4

401.63

417.54

mg/l

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

816

2.58

2.22

7.0

5.2

1.96

1.90

mu/l

0.18

747

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

149

1.99

2.21

3.6

2.7

0.28

1.15

e6/l

2.28

(3030467) Casts [#/volume] in Urine by Automated count

248

1.84

2.20

3.9

2.8

0.29

0.35

e6/l

0.13

171

(3009261) Glucose [Presence] in Urine by Test strip

479

1.80

2.19

4.2

3.9

0.00

estimate

-0.00

(3024928) Oxygen saturation in Venous blood

3.87

2.19

2.7

2.3

62.29

63.35

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

112

2.10

2.16

8.4

5.3

1.00

0.99

mmol/l

0.05

107

(3021601) Nitrite [Presence] in Urine by Test strip

471

1.78

2.15

4.2

3.8

0.00

estimate

-0.00

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.88

2.14

1.3

—

2.49

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.41

2.12

1.6

1.3

—

(3018095) Leukocytes [#/volume] in Urine

331

1.77

2.10

5.1

3.9

30.53

177.02

e6/l

0.97

224

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.68

2.09

6.2

8.9

24.70

25.33

mmol/l

0.12

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

169

1.90

2.05

4.4

3.1

2.46

mmol/l

0.01

153

(3015736) pH of Urine

380

1.74

2.02

3.9

3.2

6.20

6.14

0.11

222

(3025130) Human papilloma virus identified in Specimen

4.71

1.96

1.6

2.1

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

4.71

1.96

1.6

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.33

1.87

2.6

1.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.15

1.87

1.2

1.8

—

(3000991) Gas panel - Venous blood

2.26

1.86

5.8

7.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

216

1.77

1.86

8.9

5.4

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

150

1.88

1.85

4.4

3.0

0.81

mmol/l

0.09

145

(3008898) HLA-B27 [Presence]

2.72

1.85

1.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

485

1.69

1.81

9.1

6.6

10.43

11.10

umol/l

0.26

466

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

144

1.87

1.77

4.0

2.9

1.47

3.32

e6/l

0.68

(3037756) Immunofixation for Serum or Plasma

3.47

1.77

1.3

1.1

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.98

1.73

1.4

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

122

1.90

1.71

1.4

1.7

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

3.28

1.68

1.2

—

(3018333) Ribosomal P Ab [Presence] in Serum

3.69

1.63

1.2

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

3.69

1.63

1.2

1.4

—

(3019230) Fractional oxyhemoglobin in Venous blood

3.69

1.63

2.6

1.9

53.40

60.75

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

3.69

1.63

1.2

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

3.69

1.63

1.2

1.4

—

(3023183) Ammonium ion [Moles/volume] in Plasma

3.69

1.63

1.2

4.9

28.60

32.79

umol/l

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

3.69

1.63

1.2

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

3.12

1.60

1.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

3.12

1.60

1.0

1.1

—

(3023368) Bacteria identified in Blood by Culture

242

1.67

1.60

5.6

4.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

3.45

1.54

1.2

1.3

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

3.45

1.54

1.2

1.3

—

(40761535) Cells panel - Urine sediment

2.25

1.50

6.8

3.2

—

(3029937) Albumin [Presence] in Urine by Test strip

256

1.62

1.46

4.4

3.8

0.00

estimate

-0.00

(3042631) Mycobacterium sp identified in Specimen

3.23

1.45

2.2

4.6

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

2.37

1.44

1.4

2.3

1.91

1.45

g/l

—

(3042936) Bacteria identified in Isolate by Culture

130

1.77

1.40

2.8

1.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

3.03

1.37

2.2

4.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

226

1.60

1.32

5.2

2.1

—

(3032080) INR in Blood by Coagulation assay

401

1.53

1.32

16.9

12.8

1.18

1.23

inr

0.27

327

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

2.86

1.30

1.2

1.4

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.86

1.30

4.0

3.1

5.30

4.99

kpa

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.86

1.30

1.6

1.2

—

(3027315) Oxygen [Partial pressure] in Blood

2.86

1.30

4.0

3.1

9.08

8.59

kpa

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

168

1.64

1.25

3.4

3.2

84.46

300.12

ng/l

0.64

125

(40758558) Short blood count panel - Blood

265

1.55

1.24

11.9

6.4

—

(3019977) pH of Arterial blood

1.85

1.23

4.2

8.5

7.47

7.41

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.71

1.23

1.0

1.9

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

103

1.78

1.22

1.9

1.6

1.26

1.29

0.08

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

161

1.64

1.21

1.4

1.7

—

(3023520) Reticulocytes [#/volume] in Blood

1.87

1.20

3.2

3.4

74.21

72.71

e9/l

—

(3019150) Specific gravity of Urine by Refractometry

196

1.59

1.19

4.2

3.5

1.02

kg/l

0.38

131

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

361

1.49

1.17

4.1

3.6

0.00

estimate

-0.00

(3044640) Blood type and Crossmatch panel - Blood

305

1.51

1.17

4.7

2.2

—

(3017181) Myelocytes/Leukocytes in Blood

1.84

1.16

5.1

4.9

1.13

1.07

—

(3022313) Gas panel - Capillary blood

2.08

1.15

10.9

2.9

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.43

1.15

2.0

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

372

1.48

1.14

1.8

1.9

104.42

101.05

pmol/l

0.17

199

(3021440) Promyelocytes/Leukocytes in Blood

1.86

1.13

5.3

5.0

0.14

0.33

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

164

1.60

1.12

1.3

1.06

9.36

u/ml

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.02

1.10

7.7

3.1

1.44

1.93

mmol/l

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.45

1.10

1.0

1.4

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

763

1.62

1.09

30.2

18.4

13.64

13.66

0.04

757

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.09

1.08

2.1

2.7

1.33

1.39

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.76

1.07

2.7

2.0

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.86

1.05

1.3

1.2

267.19

122.51

u/ml

—

(3011288) Drugs identified in Urine by Screen method Nominal

2.33

1.04

1.4

2.0

—

(3026782) Osmolality of Urine

167

1.57

1.04

3.1

2.8

553.21

552.68

mosm/kgh2o

0.00

142

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

897

1.91

1.03

27.0

14.5

24.85

22.81

mg/l

0.25

733

(3007164) IgA [Mass/volume] in Serum or Plasma

203

1.52

1.02

1.5

1.4

2.98

2.48

g/l

0.51

135

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.95

0.96

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.91

0.96

1.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.21

0.93

4.3

1.6

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.98

0.91

2.3

2.7

0.59

0.63

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.13

0.91

1.3

1.7

175.33

196.48

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.89

0.88

6.0

10.9

95.24

94.78

—

(3014051) Protein [Presence] in Urine by Test strip

264

1.43

0.88

3.1

3.0

—

0.25

—

(3002179) Metamyelocytes/Leukocytes in Blood

1.73

0.86

5.4

4.9

2.43

0.34

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.93

0.83

2.7

2.1

—

(40761536) Microorganisms panel - Urine sediment

1.70

0.82

4.8

4.0

—

(3020891) Body temperature

1.87

0.80

4.7

3.6

37.00

36.97

°c

—

(3026493) Urate [Moles/volume] in Serum or Plasma

241

1.41

0.79

3.2

2.6

324.87

341.46

umol/l

0.51

216

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.68

0.79

2.0

2.6

0.21

0.22

g/l

0.14

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

2.23

0.77

2.8

2.3

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.23

0.77

2.0

1.1

—

(3025159) Blasts/Leukocytes in Blood

1.65

0.75

4.3

5.4

0.00

0.35

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

101

1.57

0.75

3.0

2.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

189

1.42

0.74

2.4

2.0

—

(3035933) Granulocytes/Leukocytes in Blood

2.05

0.73

2.8

2.5

56.00

59.08

—

(3000492) Spirometry study

1.57

0.71

2.1

1.4

—

(3010421) pH of Blood

1.89

0.69

4.2

2.6

7.39

7.41

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.82

0.67

5.2

1.6

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.82

0.67

1.4

1.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.70

0.62

1.0

1.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.61

0.0

1.1

—

1.80

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.76

0.59

5.8

2.3

—

(3016879) Cocaine [Presence] in Urine

1.76

0.59

1.3

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

1.76

0.59

1.3

1.6

—

(3028300) Cannabinoids [Presence] in Urine

1.71

0.58

1.3

1.6

—

(3027008) Opiates [Presence] in Urine

1.71

0.58

1.3

1.6

—

(3027944) Amphetamines [Presence] in Urine

1.66

0.56

1.3

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

162

1.37

0.56

1.7

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.52

0.55

2.7

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

275

1.29

0.53

3.4

3.3

0.00

estimate

-0.00

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

864

1.43

0.51

23.9

14.6

83.42

82.52

ml/min/173m2

0.16

803

(3012516) Albumin [Mass/volume] in Urine

286

1.28

0.51

3.9

3.4

41.44

55.46

mg/l

0.19

184

(3026008) Bacteria identified in Urine by Culture

230

1.30

0.50

4.3

3.5

—

(40768797) Stomach Pathology biopsy report

129

1.38

0.50

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

345

1.26

0.48

3.2

3.1

27.41

42.62

ng/l

0.50

232

(3000494) Fungus identified in Specimen by Culture

112

1.40

0.48

3.2

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

298

1.26

0.47

4.7

4.1

5.53

8.58

mg/mmol

0.42

184

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

385

1.25

0.47

2.0

1.43

1.35

mmol/l

0.32

322

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

848

1.34

0.43

7.0

5.9

41.40

39.11

mmol/mol

1.23

802

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.3

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.40

0.0

1.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.39

0.0

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

434

1.20

0.35

4.8

2.7

—

estimate

—

(3003694) ABO and Rh group [Type] in Blood

281

0.81

0.34

1.6

1.5

—

(3022145) Colonoscopy Study observation

101

1.33

0.33

1.2

1.5

—

(40768443) Skin Pathology biopsy report

1.32

0.33

1.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

854

0.81

0.31

4.5

4.2

1.61

1.27

mmol/l

2.75

791

(3001019) Free T4 and TSH panel - Serum or Plasma

1.29

0.30

1.4

1.7

—

(40768804) Tissue Pathology biopsy report

361

1.18

0.29

2.7

2.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

122

1.27

0.29

1.5

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.30

0.25

13.2

6.9

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

58.44

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

2.6

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

8.05

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3045414) Leukocytes [Presence] in Urine

1.26

0.19

1.1

2.2

0.00

estimate

—

(3002256) Pathology report gross observation

119

1.20

0.19

1.1

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.14

0.17

1.3

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.23

0.16

2.7

3.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

943

1.23

0.14

32.6

18.9

81.00

76.29

umol/l

0.44

935

(21494755) Public health laboratory ask at order entry panel

107

0.83

0.13

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

218

0.90

0.11

1.3

0.86

1.40

u/ml

—

(3019060) Gas panel - Arterial blood

1.17

0.10

3.6

4.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.15

0.09

1.5

1.7

—

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

974

0.94

0.08

42.5

22.4

40.36

40.66

0.25

967

(3035941) MCH [Entitic mass]

974

0.94

0.08

42.1

22.0

30.44

30.38

0.12

967

(3000963) Hemoglobin [Mass/volume] in Blood

974

0.94

0.08

42.6

22.3

133.55

136.14

g/l

0.79

965

(3024731) MCV [Entitic mean volume] in Red Blood Cells

973

0.95

0.08

42.1

22.1

91.74

91.24

0.47

966

(36660697) Celiac disease serology panel - Serum

1.07

0.07

1.0

1.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

898

1.11

0.07

5.8

5.7

2.69

2.75

mmol/l

0.27

843

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

102

0.87

0.06

1.6

2.1

3.60

3.43

ratio

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

889

1.09

0.05

5.1

5.0

4.58

4.68

mmol/l

0.39

832

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

241

1.05

0.03

3.4

4.1

25.40

21.73

0.32

108

(1761868) Lipid panel - Serum or Plasma

378

0.97

0.02

3.0

—

(40761511) CBC panel - Blood by Automated count

934

1.07

0.01

22.3

12.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

886

0.96

0.00

5.0

1.37

1.47

mmol/l

1.42

827

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

863

0.98

0.00

5.5

4.8

6.58

5.91

mmol/l

1.06

803

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

575

0.98

0.00

3.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

185

1.03

0.00

2.3

3.0

0.59

0.70

ug/l

0.38

111

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.92

0.00

1.2

1.4

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

14.6

—

6.88

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

3.2

—

93.60

—

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

0.96

-0.00

1.3

2.0

3.91

3.47

mmol/l

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.4

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

92.78

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.0

—

10.00

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

237.40

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

110

1.00

-0.00

1.5

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

2.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.6

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.2

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.8

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.3

—

310.00

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

141.77

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.6

—

6.82

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.3

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

14.6

—

16.16

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.4

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_ORBITINFLAMCHRON and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_ORBITINFLAMCHRON	1.538 [1.15, 2.05]	0.004
Birth year	0.999 [0.99, 1.01]	0.863

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 272 females with H7_ORBITINFLAMCHRON died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_ORBITINFLAMCHRON.

N-year risk	Females	Males
1	0.183%	No data
5	1.03%	No data
10	2.504%	No data
15	4.872%	No data
20	8.812%	No data

Relationships between endpoints

↥

Index endpoint: H7_ORBITINFLAMCHRON – Chronic inflammatory disorders of orbit

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Chronic inflammatory disorders of orbit

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints