Acute inflammation of orbit

H7_ORBITINFLAMACU

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H05.0
  • Hospital discharge: ICD-9 3760
  • Hospital discharge: ICD-8 3690[0-2]
  • Cause of death: ICD-10 H05.0
  • Cause of death: ICD-9 3760
  • Cause of death: ICD-8 3690[0-2]

2 out of 7 registries used, show all original rules.

280

4. Check minimum number of events

None

280

5. Include endpoints

None

280

6. Filter based on genotype QC (FinnGen only)

253

Control definitions (FinnGen only)

Control exclude
H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H05
Name in latin
Inflammatio orbitae acuta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2945 1284 1650
Only index persons 2527 1123 1404
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.05
Only index persons 0.05 0.04 0.05
Median age at first event (years)
Whole population 24.56 30.24 19.99
Only index persons 23.68 29.27 19.21

-FinnGen-

Key figures

All Female Male
Number of individuals 253 138 115
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 46.72 46.26 47.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
258
Matched controls
2580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
264.2
206
*
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
135.6
43.3
45
*
3760A
ICD-9 Finland
Disorders of the orbit, Acute inflammation of orbit
+∞
33.0
31
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
10.4
24.9
29
31
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
7.7
24.5
37
55
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
84.0
21.0
23
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
8.5
19.9
27
35
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.7
19.4
78
268
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.4
16.9
36
75
CAA00
NOMESCO Finland
Puncture of orbital abscess
+∞
15.8
15
*
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.9
15.0
36
83
H01.0
ICD-10 Finland
Blepharitis
5.5
14.7
30
60
H57.1
ICD-10 Finland
Ocular pain
5.9
13.8
26
48
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
+∞
13.7
13
*
H05.2
ICD-10 Finland
Exophthalmic conditions
+∞
13.7
13
*
H04.10
ICD-10 Finland
Dry eye syndrome
4.8
13.6
33
77
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
10.5
13.1
25
26
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
+∞
12.6
12
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
+∞
12.6
12
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.5
12.5
32
78
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.6
12.4
114
603
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.7
12.2
92
441
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
11.9
83
382
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
+∞
11.5
11
*
36900
ICD-8 Finland
Other inflammatory diseases of eye, Abscessus orbitae
+∞
11.5
11
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.6
11.3
90
441
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
29.5
10.8
14
5
H02AB06
ATC
prednisolone; systemic
2.4
10.7
134
803
H05.9
ICD-10 Finland
Disorder of orbit, unspecified
+∞
10.5
10
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
10.5
10
*
CA1AD
NOMESCO Finland
Orbita CT
+∞
10.5
10
*
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
34.1
10.4
13
*
UDM02
NOMESCO Finland
Sinoscopy
9.7
9.7
19
21
XCK10
NOMESCO Finland
Photography of fundus of eye
3.6
9.7
34
104
WX002
NOMESCO Finland
Sedation and analgesia
2.8
9.7
55
225
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.8
9.5
31
90
CA1BD
NOMESCO Finland
Extensive orbita CT
+∞
9.4
9
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.3
8.7
35
117
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.5
8.7
32
101
J31.0
ICD-10 Finland
Chronic rhinitis
3.3
8.6
34
112
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.4
8.5
33
108
H02AB07
ATC
prednisone; oral
3.0
8.5
42
159
36902
ICD-8 Finland
Other inflammatory diseases of eye, Tenonitis
+∞
8.4
8
*
H05.1
ICD-10 Finland
Chronic inflammatory disorders of orbit
+∞
8.4
8
*
Z97.0
ICD-10 Finland
Presence of artificial eye
+∞
8.4
8
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.7
8.0
19
43
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
7.9
119
743
XCK00
NOMESCO Finland
Perimetry
4.4
7.9
20
48
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
25.9
7.6
10
*
F29
ICPC
Eye symptom/complaint other
2.9
7.5
39
151
R01AD09
ATC
mometasone; nasal
2.1
7.4
127
826
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
+∞
7.3
7
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
7.3
7
*
H05.8
ICD-10 Finland
Other disorders of orbit
+∞
7.3
7
*
ZXA00
NOMESCO Finland
Right side
2.3
7.3
68
349
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
7.3
35
130
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
31.0
7.2
9
*
J01.4
ICD-10 Finland
Acute pansinusitis
20.7
7.2
10
5
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.9
7.1
35
132
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
7.1
36
138
J01MA14
ATC
moxifloxacin; systemic
3.2
7.1
29
98
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
7.0
6.9
16
24
S01AD03
ATC
aciclovir; ophthalmic
6.4
6.9
17
28
Z3231
NOMESCO Finland
Registered nurse
2.2
6.9
77
425
N02AX02
ATC
tramadol; systemic, rectal
2.0
6.9
112
711
J01FF01
ATC
clindamycin; systemic
2.1
6.9
79
441
ZXE00
NOMESCO Finland
One hour or less
2.0
6.8
102
628
H02.4
ICD-10 Finland
Ptosis of eyelid
41.2
6.8
8
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.2
6.7
71
383
H16.9
ICD-10 Finland
Keratitis, unspecified
9.1
6.6
13
15
J01DB01
ATC
cefalexin; oral
2.5
6.6
221
1812
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
6.5
96
586
WX720
NOMESCO Finland
Own respiration
3.9
6.5
19
51
J34.1
ICD-10 Finland
Cyst and mucocele of nose and nasal sinus
11.4
6.4
11
10
CAE10
NOMESCO Finland
Revision and secondary implant in orbit
+∞
6.3
6
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
6.2
57
289
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
6.2
119
793
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
6.1
46
215
ZXA05
NOMESCO Finland
Left side
2.2
6.0
61
322

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
89
231
5.36
33.85
2.3
1.7
—
—
—
0
0
78
276
3.62
18.47
2.2
1.9
—
—
—
0
0
104
521
2.67
12.72
4.9
4.1
—
—
—
0
0
26
59
4.79
11.01
1.7
1.3
—
—
—
0
0
28
72
4.24
10.15
1.5
1.4
—
—
—
0
0
118
701
2.26
9.26
10.8
6.5
—
—
—
0
0
165
1132
2.27
8.99
10.8
6.5
1.90
2.02
e9/l
0.32
151
1020
160
1098
2.20
8.53
10.9
6.5
0.58
0.57
e9/l
0.40
146
959
160
1100
2.20
8.46
10.9
6.5
0.04
0.04
e9/l
0.09
145
961
22
54
4.36
8.44
1.9
1.8
1.36
4.57
iu/l
1.35
12
20
162
1140
2.13
7.80
11.0
6.8
0.19
0.18
e9/l
0.22
146
1015
169
1215
2.13
7.61
15.8
10.2
4.28
3.97
e9/l
0.78
155
1071
54
250
2.47
7.32
1.9
1.5
—
—
—
0
0
60
296
2.34
7.05
1.5
1.4
470.59
550.99
titre
0.18
17
71
56
275
2.32
6.63
2.0
2.9
4.31
5.45
e9/l
0.66
50
252
127
857
1.95
6.43
7.6
4.9
35.26
36.39
g/l
1.46
121
824
143
1007
1.94
6.35
11.9
6.5
0.67
0.67
%
0.06
138
954
43
192
2.49
6.26
5.5
4.8
7.37
7.39
ph
1.16
30
116
23
73
3.36
6.18
2.3
2.2
—
—
—
0
0
41
185
2.45
5.83
5.7
4.8
1.14
1.80
mmol/l
0.61
35
156
101
652
1.90
5.67
2.6
2.4
69.19
62.26
u/l
0.16
94
609
161
1213
1.87
5.48
8.0
4.6
6.75
6.52
mmol/l
0.65
148
1126
92
584
1.89
5.39
3.3
2.1
182.55
198.41
u/l
0.10
84
556
34
148
2.49
5.21
1.9
1.2
236.97
357.91
u/ml
0.39
34
139
133
956
1.81
5.16
14.8
7.2
1.20
1.21
mmol/l
0.81
122
837
122
858
1.80
5.07
13.0
6.5
1.21
1.21
mmol/l
0.21
117
801
98
646
1.83
5.03
8.9
6.3
—
—
—
0
0
11
16
7.13
5.00
1.5
1.5
3.11
3.74
u/ml
—
11
10
86
547
1.86
4.94
2.2
2.1
—
—
—
0
0
82
519
1.85
4.75
2.9
2.2
2.86
2.89
mg/l
0.04
76
456
36
169
2.31
4.68
4.2
3.1
67.40
71.51
e9/l
0.35
30
127
24
93
2.74
4.62
1.3
2.6
5.40
6.36
iu/ml
—
5
23
72
443
1.87
4.54
4.1
2.5
8.96
6.06
e6/l
0.63
65
402
11
19
6.00
4.49
1.5
1.2
—
—
—
0
0
193
1586
1.86
4.49
12.4
7.9
82.72
79.33
u/l
0.38
184
1501
10
16
6.45
4.33
2.5
4.3
2909.90
853.06
u/ml
—
10
16
53
299
1.97
4.31
4.0
2.5
2.36
2.41
g/l
0.25
48
275
18
62
3.05
4.26
1.7
1.5
—
—
—
0
0
65
395
1.86
4.23
1.4
1.3
43.47
29.03
iu/ml
0.43
14
124
145
1110
1.70
4.19
8.6
6.6
10.15
11.38
umol/l
1.39
138
1060
12
26
4.79
4.11
8.0
3.3
—
—
—
0
0
63
384
1.85
4.05
3.3
2.7
541.87
544.83
mosm/kgh2o
0.04
55
332
55
322
1.90
4.00
3.9
2.5
13.48
13.23
umol/l
0.08
49
298
70
447
1.78
3.85
2.0
1.8
—
—
—
0
0
96
671
1.69
3.82
3.5
3.3
2.34
2.35
mmol/l
0.29
88
625
115
849
1.64
3.67
2.2
1.9
94.03
98.43
pmol/l
0.46
64
447
14
46
3.16
3.58
11.1
2.0
1.57
1.39
ratio
—
9
22
117
874
1.62
3.53
16.0
10.8
1.28
1.19
inr
0.75
104
727
6
6
10.20
3.51
1.3
1.7
—
—
—
0
0
81
552
1.68
3.50
3.6
2.8
—
—
—
0
0
130
998
1.61
3.49
14.5
10.4
0.00
0.00
e9/l
0.53
116
805
113
840
1.61
3.46
2.2
2.0
—
—
—
0
0
24
108
2.35
3.44
1.6
1.6
—
—
—
0
0
10
23
4.48
3.34
2.3
2.7
36.01
38.52
%
—
10
23
33
173
2.04
3.28
10.0
10.4
—
—
—
0
0
75
510
1.66
3.24
6.4
4.0
91.12
93.18
%
0.28
75
505
94
678
1.61
3.21
4.4
3.0
21.18
51.99
e6/l
1.47
75
513
82
572
1.64
3.20
7.3
3.7
7.40
7.40
ph
0.14
68
403
30
154
2.07
3.15
1.1
1.2
28.34
131.41
u/ml
—
8
61
12
35
3.54
3.15
2.8
1.2
—
—
—
0
0
31
162
2.04
3.11
12.7
8.0
9.24
8.06
mmol/l
0.49
31
153
25
120
2.20
3.10
2.2
4.0
4.61
4.68
pmol/l
0.15
25
108
50
308
1.77
3.07
2.0
1.7
—
—
—
0
0
235
2138
2.11
3.03
26.3
13.3
23.99
23.30
mg/l
0.12
205
1716
56
358
1.72
3.02
4.4
3.4
415.45
236.53
ng/l
0.29
38
252
15
57
2.73
3.02
2.0
1.5
132.60
125.46
au/ml
—
5
21
34
187
1.94
2.96
2.6
2.6
0.19
0.22
g/l
1.56
34
176
80
564
1.61
2.96
1.8
1.6
18.83
20.59
nmol/l
0.56
66
485
92
671
1.58
2.95
3.7
2.4
—
—
—
0
0
133
1057
1.53
2.89
3.9
2.9
153.79
112.49
ug/l
0.65
127
996
192
1660
1.61
2.82
5.3
4.0
14.77
14.72
pmol/l
0.10
182
1522
9
23
4.02
2.80
1.3
1.3
—
—
—
0
0
80
573
1.57
2.75
3.9
3.0
0.27
0.24
e6/l
0.09
62
415
6
10
6.11
2.71
1.3
1.0
—
—
—
0
0
24
120
2.10
2.71
1.4
1.2
—
—
—
0
0
9
24
3.85
2.70
3.0
3.3
—
—
—
0
0
126
1001
1.51
2.68
3.3
2.7
—
—
estimate
—
0
0
34
195
1.86
2.63
1.6
1.7
—
—
—
0
0
7
15
4.76
2.61
1.1
1.2
—
—
—
0
0
15
62
2.51
2.59
1.5
1.7
204.78
174.65
u/ml
—
9
37
36
212
1.81
2.56
1.2
1.2
—
—
—
0
0
10
31
3.31
2.54
3.9
3.1
—
—
—
0
0
10
31
3.31
2.54
1.4
1.4
—
—
—
0
0
102
783
1.50
2.52
5.3
3.7
46.71
99.61
e6/l
0.66
75
543
9
26
3.55
2.50
1.1
1.6
—
—
—
0
0
9
26
3.55
2.50
1.1
1.6
—
—
—
0
0
9
26
3.55
2.50
1.1
1.6
—
—
—
0
0
9
26
3.55
2.50
1.1
1.6
—
—
—
0
0
49
319
1.66
2.46
1.9
1.9
—
—
—
0
0
10
32
3.21
2.46
1.3
1.2
—
—
—
0
0
178
1534
1.52
2.45
4.1
3.3
59.18
44.99
u/l
0.56
169
1471
20
97
2.15
2.44
7.2
4.2
—
—
—
0
0
5
8
6.35
2.38
2.0
1.0
—
—
—
0
0
12
47
2.63
2.30
3.8
3.1
7.39
5.43
umol/l
—
7
38
11
40
2.83
2.30
1.1
1.1
—
—
—
0
0
24
129
1.95
2.26
1.1
1.2
—
27.26
—
0
7
53
362
1.58
2.20
1.3
1.3
12.24
10.50
u/ml
0.09
18
157
8
24
3.41
2.20
1.4
1.1
—
—
—
0
0
14
61
2.37
2.19
1.1
1.1
0.74
6.67
u/ml
—
9
39
5
10
5.07
2.08
1.0
1.5
—
—
—
0
0
21
111
1.97
2.08
8.2
1.7
—
—
—
0
0
6
15
4.07
2.05
1.5
1.1
—
—
—
0
0
69
508
1.49
2.03
3.9
2.7
328.21
337.79
umol/l
0.37
61
457
7
21
3.40
1.98
1.1
1.1
—
—
—
0
0
7
21
3.40
1.98
2.7
2.9
—
—
—
0
0
7
21
3.40
1.98
1.1
1.3
—
—
—
0
0
8
27
3.02
1.95
1.3
1.2
—
—
—
0
0
5
11
4.61
1.95
1.2
1.0
1469.80
1487.73
miu/ml
—
5
11
5
11
4.61
1.95
1.4
1.1
—
—
—
0
0
6
16
3.81
1.94
1.0
1.2
—
—
—
0
0
12
52
2.37
1.90
4.1
2.8
7.39
7.41
ph
1.30
12
52
19
101
1.95
1.86
3.9
2.3
1814.34
4706.12
u/l
—
10
37
30
185
1.70
1.85
5.6
4.7
0.00
0.08
%
—
8
52
6
17
3.59
1.85
1.8
1.7
3.23
5.01
mg/l
—
6
17
90
710
1.41
1.83
5.9
3.4
7.33
8.09
mmol/l
1.15
78
622
32
202
1.67
1.82
10.8
8.5
7.38
7.42
ph
1.08
19
116
29
180
1.69
1.76
5.6
4.4
0.00
0.23
%
—
8
57
9
36
2.55
1.75
4.0
2.8
9.09
8.89
kpa
—
9
36
9
36
2.55
1.75
4.0
2.8
5.40
4.96
kpa
—
9
36
6
18
3.39
1.75
1.5
2.1
—
—
—
0
0
15
75
2.06
1.73
4.7
6.1
781.50
277.61
mg/l
—
10
36
5
13
3.90
1.72
3.6
1.5
2900.00
1536.54
ml
—
5
13
79
615
1.41
1.72
6.1
3.4
79.58
63.24
mg/l
0.18
57
405
28
175
1.67
1.66
1.7
1.4
—
—
—
0
0
67
510
1.42
1.64
5.2
4.7
—
—
—
0
0
28
177
1.65
1.60
6.1
4.3
0.62
0.55
%
—
8
57
16
85
1.94
1.59
1.6
1.5
10.50
7.66
u/l
—
9
71
31
204
1.59
1.52
11.0
8.4
-0.00
0.84
mmol/l
0.62
24
171
13
65
2.05
1.51
1.2
1.2
0.21
3.12
u/ml
—
8
40
6
21
2.90
1.51
8.8
2.7
64.00
65.98
%
—
6
21
10
45
2.27
1.48
1.5
1.1
—
—
—
0
0
38
264
1.52
1.48
8.9
7.6
104.61
104.40
mmol/l
0.09
38
264
79
630
1.37
1.47
7.0
3.9
20.37
9.88
mg/mmol
0.50
52
395
29
191
1.58
1.42
5.6
4.3
0.67
0.93
%
—
9
67
21
127
1.71
1.41
19.9
11.4
24.93
24.77
mmol/l
0.07
21
127
16
89
1.85
1.40
1.3
1.3
—
—
—
0
0
64
498
1.38
1.38
4.1
3.2
—
0.00
—
0
5
5
17
2.98
1.36
2.0
1.5
12.40
17.24
ng/l
—
5
17
106
897
1.31
1.30
4.0
3.0
6.09
6.22
ph
0.57
58
506
5
18
2.81
1.29
3.2
1.9
11.00
10.09
mmol/l
—
5
18
40
291
1.44
1.25
2.1
1.6
1128.18
1169.70
nmol/l
0.11
35
229
129
1125
1.29
1.25
4.6
3.3
0.00
0.00
estimate
-0.00
29
240
131
1145
1.29
1.24
4.6
3.4
0.00
0.00
estimate
-0.00
29
233
75
609
1.33
1.22
3.2
2.7
—
0.13
—
0
15
43
320
1.41
1.20
2.8
2.6
205.06
86.57
ug/g
0.62
34
254
50
384
1.37
1.17
1.6
1.7
448.57
35030381.24
pmol/l
0.50
44
334
36
263
1.43
1.11
1.2
1.2
—
—
—
0
0
5
21
2.41
1.09
13.0
17.3
534.80
938.48
nmol/l
—
5
21
102
875
1.27
1.09
1.9
1.9
1.38
1.39
mmol/l
0.03
85
754
7
33
2.15
1.06
1.4
1.1
—
—
—
0
0
7
33
2.15
1.06
3.7
3.2
3.85
3.85
e9/l
—
7
33
76
902
0.78
1.05
2.7
2.9
—
—
—
0
0
11
60
1.87
1.04
1.5
1.3
—
—
—
0
0
81
679
1.28
1.03
1.6
1.6
—
—
—
0
0
9
47
1.95
1.03
3.8
2.6
55.22
57.99
%
—
9
47
232
2219
1.45
1.01
20.5
11.9
—
—
—
0
0
18
269
0.64
1.00
1.3
1.4
—
—
—
0
0
42
322
1.36
1.00
3.3
3.0
6.46
2.71
e6/l
0.43
21
159
34
252
1.40
0.98
3.8
3.2
4.29
8.67
umol/l
2.12
28
220
5
23
2.20
0.98
1.8
1.8
—
—
—
0
0
87
741
1.26
0.97
4.5
3.5
53.10
114.67
ng/l
0.32
63
487
14
85
1.68
0.96
1.3
1.9
—
—
—
0
0
11
62
1.81
0.95
1.6
1.3
—
—
—
0
0
127
1134
1.24
0.92
4.7
3.3
0.00
0.00
estimate
-0.00
29
245
11
63
1.78
0.91
1.1
1.1
—
—
—
0
0
15
96
1.60
0.86
1.6
1.5
22.38
24.12
iu/l
—
10
83
209
1981
1.29
0.84
6.6
4.8
1.77
1.84
mu/l
0.45
203
1845
15
97
1.58
0.83
1.1
1.1
—
—
—
0
0
5
96
0.51
0.80
1.0
1.1
—
0.73
—
0
12
25
183
1.41
0.79
12.2
4.0
7.38
7.34
ph
1.28
20
134
8
48
1.69
0.79
1.6
2.0
—
—
—
0
0
12
75
1.63
0.76
1.3
1.1
—
—
—
0
0
5
24
2.10
0.75
7.2
3.7
—
—
—
0
0
14
92
1.55
0.74
1.9
1.6
—
—
—
0
0
5
25
2.02
0.73
1.0
1.3
—
—
—
0
0
5
27
1.87
0.69
1.0
1.2
—
—
—
0
0
5
27
1.87
0.69
1.2
1.1
—
—
—
0
0
23
171
1.38
0.68
6.0
3.4
—
—
—
0
0
59
502
1.23
0.66
3.9
3.2
1.00
1.02
kg/l
0.48
47
319
19
138
1.41
0.64
4.2
2.9
—
—
—
0
0
8
50
1.62
0.62
1.0
1.1
—
—
—
0
0
8
50
1.62
0.62
1.0
1.1
—
—
—
0
0
71
620
1.20
0.62
5.0
3.4
0.00
0.00
estimate
-0.00
28
228
6
35
1.73
0.58
3.0
2.5
90.68
92.61
%
—
6
35
29
233
1.28
0.54
1.3
1.4
—
—
—
0
0
33
270
1.25
0.53
1.1
1.2
—
—
—
0
0
6
96
0.62
0.53
1.2
1.1
1.51
1.56
g/l
—
6
96
60
524
1.19
0.52
3.2
1.4
2.41
2.30
g/l
0.17
40
318
23
181
1.30
0.50
2.7
5.2
2.71
32.64
ug/l
0.70
16
151
10
68
1.49
0.47
3.8
2.4
23.12
24.59
mmol/l
—
10
68
65
577
1.17
0.47
1.6
1.3
0.81
1.27
u/ml
0.68
16
160
70
626
1.16
0.46
4.2
4.9
5.87
2.41
ug/l
0.37
56
567
5
32
1.57
0.42
1.6
1.3
59.40
65.37
mmol/l
—
5
27
54
477
1.17
0.42
2.0
1.8
2.04
1.23
mg/l
0.41
43
371
93
855
1.14
0.42
4.5
3.2
0.00
0.00
estimate
0.50
22
211
0
15
0.00
0.41
0.0
1.1
—
69.65
—
0
10
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
90250.00
—
0
6
8
59
1.37
0.41
2.6
2.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
1763.00
—
0
9
0
16
0.00
0.41
0.0
1.0
—
269.63
—
0
8
5
35
1.44
0.39
6.0
2.9
10.86
8.05
pmol/l
—
5
35
5
37
1.36
0.37
1.8
2.1
—
—
—
0
0
19
153
1.26
0.36
2.2
1.7
—
—
—
0
0
6
43
1.40
0.35
5.8
1.8
60.50
70.15
%
—
6
43
19
154
1.25
0.35
2.2
1.7
—
—
—
0
0
19
154
1.25
0.35
2.2
1.7
—
—
—
0
0
19
154
1.25
0.35
2.2
1.7
—
—
—
0
0
10
133
0.74
0.34
1.2
1.1
—
—
—
0
0
14
109
1.30
0.34
5.8
2.6
0.59
0.61
%
0.10
14
109
7
98
0.71
0.31
1.7
1.1
0.80
0.93
g/l
—
7
98
14
113
1.25
0.27
15.6
4.0
—
—
—
0
0
9
73
1.24
0.25
1.8
2.0
—
—
—
0
0
17
142
1.21
0.25
1.0
1.2
—
—
—
0
0
5
39
1.29
0.23
1.0
1.2
—
—
—
0
0
17
144
1.19
0.22
2.2
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
176.42
—
0
11
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
0.00
—
0
11
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
28
251
1.13
0.19
1.5
1.4
—
—
—
0
0
205
2079
0.93
0.14
5.2
4.7
1.39
1.46
mmol/l
1.50
191
1954
208
2107
0.93
0.13
6.2
5.3
2.72
2.74
mmol/l
0.16
195
1988
67
641
1.06
0.13
4.1
2.9
0.00
0.00
estimate
-0.00
24
197
203
2002
1.07
0.13
5.7
4.6
5.96
5.83
mmol/l
0.53
189
1859
206
2086
0.94
0.12
5.4
4.7
4.57
4.66
mmol/l
0.60
193
1970
201
1985
1.06
0.11
4.5
4.0
1.34
1.28
mmol/l
0.47
188
1860
12
107
1.13
0.08
2.6
2.1
—
—
—
0
0
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
19
176
1.09
0.07
3.1
1.8
6.35
6.11
ph
0.47
13
113
6
74
0.81
0.07
1.5
1.4
—
—
—
0
0
6
74
0.81
0.07
1.3
1.6
—
—
—
0
0
10
110
0.91
0.05
1.4
1.6
—
—
—
0
0
13
122
1.07
0.02
2.6
1.8
—
—
—
0
0
19
184
1.04
0.00
2.9
1.9
0.00
0.07
estimate
—
5
44
33
332
0.99
0.00
1.8
1.6
—
—
—
0
0
37
375
0.98
0.00
3.2
2.9
0.53
0.77
ug/l
2.00
25
235
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
7
76
0.92
-0.00
1.4
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
66
0.91
-0.00
1.5
1.4
—
97.00
—
0
10
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.3
—
13.73
—
0
6
0
7
0.00
-0.00
0.0
2.3
—
55.71
—
0
7
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_ORBITINFLAMACU and mortality.

Females

Parameter HR [95% CI] p-value
H7_ORBITINFLAMACU 1.673 [1.29, 2.17] < 0.001
Birth year 0.995 [0.99, 1.0] 0.21

During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 905 females with H7_ORBITINFLAMACU died.

Males

Parameter HR [95% CI] p-value
H7_ORBITINFLAMACU 1.943 [1.47, 2.57] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 1125 males with H7_ORBITINFLAMACU died.

Mortality risk

Mortality risk for people of age

years, who have H7_ORBITINFLAMACU.

N-year risk Females Males
1 0.162% 0.408%
5 0.981% 2.215%
10 2.452% 5.405%
15 4.582% 9.94%
20 7.866% 16.688%

Relationships between endpoints

Index endpoint: H7_ORBITINFLAMACU – Acute inflammation of orbit

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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