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Mild or no visual impairment, binocular

DOID Endpoint Browser PheWeb

H7_MILDVISIMPBINOC

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H54.3
  • Cause of death: ICD-10 — H54.3

2 out of 7 registries used, show all original rules.

201

4. Check minimum number of events

None

201

5. Include endpoints

None

201

6. Filter based on genotype QC (FinnGen only)

176

Control definitions (FinnGen only)

Control exclude
H7_VISUALDISTBLIND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H54
Name in latin
Amblyopia non specificata oculorum amborum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1613 870 732
Only index persons 1433 791 642
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 42.74 48.39 35.96
Only index persons 44.24 49.24 38.09

-FinnGen-

Key figures

All Female Male
Number of individuals 176 120 56
Unadjusted period prevalence (%) 0.04 0.04 0.03
Median age at first event (years) 56.23 53.01 63.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
188
Matched controls
1880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
+∞
272.1
188
*
XCK00
NOMESCO Finland
Perimetry
17.6
56.9
52
40
XCW99
NOMESCO Finland
Other investigative procedure of eye
9.7
40.1
56
79
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
+∞
40.0
37
*
H53.4
ICD-10 Finland
Visual field defects
386.4
33.0
32
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
7.0
31.8
61
121
Z3229
NOMESCO Finland
Other healthcare associate professional
7.5
29.1
49
84
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.5
25.1
36
51
H53.1
ICD-10 Finland
Subjective visual disturbances
25.0
25.0
35
17
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.0
24.1
71
203
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.8
23.7
43
79
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.8
20.6
44
94
XCK10
NOMESCO Finland
Photography of fundus of eye
5.9
20.3
42
87
H47.2
ICD-10 Finland
Optic atrophy
+∞
19.1
18
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
20.8
18.4
27
15
N03AG01
ATC
valproic acid; systemic, rectal
6.6
17.4
31
55
ZXA10
NOMESCO Finland
Bilateral
3.9
16.1
61
204
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.7
14.7
25
42
H54.7
ICD-10 Finland
Unspecified visual loss
46.5
14.4
17
*
SPAT1229
SPAT
Assessment of need for aid
6.0
14.2
27
51
AA1AD
NOMESCO Finland
CT of head and brain
3.3
13.5
73
303
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.1
13.5
25
46
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
13.7
13.0
22
18
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
138.9
12.6
13
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
12.5
110
597
H04.10
ICD-10 Finland
Dry eye syndrome
3.9
12.1
41
125
R4120
NOMESCO Finland
Occupational therapy
5.2
11.8
26
56
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.0
11.6
38
113
TAB00
NOMESCO Finland
Lumbar puncture
5.8
11.4
22
42
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.6
11.3
29
71
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.1
10.9
34
97
L28
ICPC
Limited function/disability (L)
3.2
10.8
55
217
N03AX14
ATC
levetiracetam; systemic
13.1
10.6
18
15
A28
ICPC
Limited function/disability NOS
3.2
10.5
51
195
H54.0
ICD-10 Finland
Blindness, binocular
+∞
10.5
10
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
42.5
10.1
12
*
Z2446
NOMESCO Finland
Social worker
4.2
9.7
28
75
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.5
9.6
25
62
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.0
9.6
22
49
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
9.5
41
145
H53.2
ICD-10 Finland
Diplopia
31.8
9.5
12
*
ZXA00
NOMESCO Finland
Right side
2.8
9.5
64
293
N02AX02
ATC
tramadol; systemic, rectal
2.6
9.4
91
499
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
9.3
48
189
R4110
NOMESCO Finland
Physiotherapy
2.7
9.2
68
325
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.5
8.9
34
111
H46
ICD-10 Finland
Optic neuritis
52.5
8.8
10
*
CS494
NOMESCO Finland
Other visual field testing
12.4
8.7
15
13
R42
ICD-10 Finland
Dizziness and giddiness
2.7
8.7
59
269
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.5
8.6
18
23
Z3231
NOMESCO Finland
Registered nurse
2.6
8.6
72
365
R3120
NOMESCO Finland
Training in mobility skills
94.1
8.5
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
8.4
81
437
R50.9
ICD-10 Finland
Fever, unspecified
3.0
8.3
44
175
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.0
8.3
25
69
NA1AD
NOMESCO Finland
Cervical spine CT examination
5.1
8.3
18
38
H53.9
ICD-10 Finland
Visual disturbance, unspecified
9.6
8.2
16
18
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
35.0
8.2
10
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
7.2
8.1
19
29
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
8.0
59
279
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.5
7.8
30
98
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
47.0
7.8
9
*
H02AB06
ATC
prednisolone; systemic
2.4
7.8
104
645
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
12.6
7.7
13
11
K90
ICPC
Stroke/cerebrovascular accident
10.7
7.7
14
14
H53.0
ICD-10 Finland
Amblyopia ex anopsia
83.2
7.5
8
*
N03AX09
ATC
lamotrigine; oral
4.3
7.4
20
51
H57.1
ICD-10 Finland
Ocular pain
4.8
7.3
17
38
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
7.3
7
*
N03AF02
ATC
oxcarbazepine; oral
6.5
7.3
18
30
N99
ICPC
Neurological disease other
21.0
7.2
10
5
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
7.2
82
471
WX140
NOMESCO Finland
Parabulbar anesthesy
6.3
7.1
18
31
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
7.0
53
253
M05BA04
ATC
alendronic acid; oral
3.6
7.0
24
73
Z3226
NOMESCO Finland
Physiotherapist
2.6
6.9
48
220
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.2
6.8
29
101
Z2221
NOMESCO Finland
Medical doctor
2.4
6.8
65
344
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.2
6.7
29
102
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.8
6.6
38
157
ZXE00
NOMESCO Finland
One hour or less
2.2
6.5
84
502
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
72.2
6.5
7
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.8
6.4
36
147
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.5
6.4
23
72
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.0
6.4
19
52
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.1
6.3
29
106
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
+∞
6.3
6
*
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
27.7
6.3
8
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
6.3
48
229
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.6
6.2
43
195
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
6.2
89
552
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
8.1
6.2
13
17
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
6.1
38
164
R5140
NOMESCO Finland
Monitoring the use of the aid
3.1
6.0
27
97

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
140
904
3.15
11.05
9.2
4.8
6.68
6.49
mmol/l
0.46
135
850
127
780
2.94
10.95
8.6
6.7
1.21
1.22
mmol/l
0.52
113
676
116
685
2.81
10.69
8.7
6.5
1.21
1.22
mmol/l
0.52
108
635
98
551
2.63
9.66
9.2
5.9
—
—
—
0
0
45
170
3.17
9.40
5.2
6.4
0.86
0.99
mmol/l
0.08
38
138
45
170
3.17
9.40
5.5
6.4
7.43
7.42
ph
0.67
23
93
111
672
2.59
9.25
12.9
11.5
1.17
1.21
inr
0.33
92
550
77
394
2.62
9.09
5.1
3.9
—
—
—
0
0
120
761
2.59
8.96
11.2
6.3
0.63
0.65
%
0.15
113
710
120
770
2.54
8.60
11.2
6.3
8.16
8.54
%
1.03
113
726
119
763
2.52
8.51
10.8
6.3
2.53
2.78
%
0.66
111
718
107
654
2.48
8.49
5.7
4.7
36.01
35.85
g/l
0.12
102
619
120
774
2.52
8.45
10.2
6.2
58.83
57.08
%
0.82
114
741
44
174
3.00
8.44
5.4
6.2
11.60
12.04
kpa
0.21
39
168
120
786
2.46
7.99
10.3
6.3
26.81
28.46
%
0.89
114
753
58
274
2.62
7.90
4.9
3.9
256.64
251.03
ng/l
0.01
44
198
32
111
3.27
7.61
5.3
4.1
7.40
7.42
ph
0.78
27
83
126
862
2.40
7.33
10.4
6.6
0.19
0.19
e9/l
0.07
114
742
123
834
2.37
7.29
10.1
6.3
0.59
0.56
e9/l
0.61
107
703
39
156
2.89
7.27
3.9
2.2
28.53
30.31
u/l
0.19
34
131
125
856
2.37
7.20
9.9
6.3
1.91
2.03
e9/l
0.36
114
746
123
837
2.36
7.18
9.9
6.3
0.04
0.04
e9/l
0.17
107
702
24
72
3.67
7.11
3.5
3.8
—
—
—
0
0
102
657
2.21
6.60
2.5
2.1
96.68
96.31
pmol/l
0.02
57
336
26
88
3.27
6.41
1.7
2.9
—
—
—
0
0
17
44
4.15
6.14
2.2
2.8
0.09
2.79
index
1.84
11
24
84
512
2.16
6.13
2.5
2.2
—
—
—
0
0
81
488
2.16
6.08
4.0
2.3
50.75
75.80
u/l
1.26
72
456
26
93
3.08
5.85
1.3
1.3
—
65.00
—
0
6
74
443
2.11
5.54
2.1
1.6
16.28
21.40
nmol/l
2.71
65
383
126
920
2.12
5.48
13.2
9.8
4.49
4.01
e9/l
1.31
111
795
80
495
2.07
5.48
4.9
3.0
—
—
—
0
0
151
1185
2.39
5.47
11.6
7.4
79.05
80.99
u/l
0.28
144
1120
115
819
2.04
5.27
7.9
6.0
9.02
11.70
umol/l
3.21
106
783
91
597
2.02
5.25
6.7
4.4
204.21
70.98
e6/l
0.77
61
411
41
200
2.34
5.03
6.5
5.7
0.99
1.12
mmol/l
1.84
41
184
73
450
2.02
4.95
5.3
3.4
0.34
0.35
e6/l
0.02
50
321
83
537
1.98
4.89
5.3
3.9
44.86
23.35
ng/l
0.58
62
371
23
86
2.91
4.79
5.0
3.8
—
—
—
0
0
82
532
1.96
4.77
5.4
3.4
105.82
56.87
e6/l
0.30
61
401
32
146
2.44
4.53
2.3
2.4
0.22
0.22
g/l
0.14
32
139
26
110
2.58
4.30
8.2
8.1
25.35
24.85
mmol/l
0.25
26
110
58
344
1.99
4.29
4.1
2.8
6.95
5.61
e6/l
0.51
53
315
30
138
2.40
4.17
3.3
4.0
7.38
7.34
ph
0.94
23
91
24
100
2.60
4.09
7.1
8.1
92.62
93.11
%
0.10
24
100
51
294
2.01
4.06
3.9
3.1
545.94
543.17
mosm/kgh2o
0.03
46
259
59
358
1.94
4.06
2.4
1.9
1.16
1.55
mg/l
0.43
44
280
43
233
2.10
4.05
2.4
2.3
2.40
2.36
g/l
0.16
37
215
72
470
1.86
3.96
6.0
4.0
7.41
7.39
ph
1.25
56
343
40
214
2.10
3.88
6.0
5.8
104.92
104.64
mmol/l
0.11
40
214
58
355
1.92
3.87
3.2
3.0
326.98
331.28
umol/l
0.11
52
304
6
5
12.33
3.79
1.0
1.0
180.00
145.60
nmol/l
—
6
5
31
151
2.26
3.78
9.3
7.8
—
—
—
0
0
12
29
4.35
3.78
1.3
2.4
—
—
—
0
0
34
173
2.18
3.74
6.1
4.5
0.59
1.77
mmol/l
0.82
29
148
101
743
1.78
3.67
3.0
2.6
—
—
estimate
—
0
0
34
180
2.09
3.38
6.2
4.5
7.38
7.39
ph
0.66
25
112
45
264
1.93
3.37
4.7
3.4
1.85
2.27
e6/l
0.18
17
133
103
781
1.71
3.21
3.7
3.0
113.38
92.48
ug/l
0.50
94
735
35
192
2.01
3.16
1.2
1.2
—
—
—
0
0
34
185
2.02
3.14
4.2
2.8
5.12
7.63
umol/l
1.11
26
161
34
565
0.51
3.12
2.8
3.0
—
—
—
0
0
64
429
1.75
3.10
2.7
2.2
2.96
3.04
mg/l
0.10
56
375
34
186
2.01
3.09
3.9
1.6
—
—
—
0
0
19
83
2.43
2.95
2.4
1.4
0.27
0.29
mg/l
—
8
29
17
71
2.53
2.89
2.8
1.6
13.74
5.82
iu/ml
—
5
17
16
65
2.60
2.87
5.7
4.9
36.89
36.97
°c
0.40
16
65
18
81
2.35
2.63
6.0
7.2
17.23
15.39
%
1.62
18
76
15
62
2.54
2.61
3.4
3.4
1.75
1.60
%
0.16
15
57
73
529
1.62
2.56
3.3
2.9
2.34
2.36
mmol/l
0.67
65
484
38
230
1.82
2.56
1.7
1.4
480.00
538.72
titre
0.13
13
47
19
90
2.24
2.49
7.0
5.6
24.58
24.68
mmol/l
0.05
19
84
23
119
2.06
2.43
4.7
5.3
0.56
0.68
%
—
9
34
5
8
6.38
2.38
1.8
1.8
16.16
14.65
%
—
5
8
8
23
3.58
2.29
1.0
1.4
—
—
—
0
0
23
123
1.99
2.23
2.6
3.1
75.91
70.16
e9/l
0.35
15
96
27
153
1.89
2.23
1.7
1.4
—
—
—
0
0
170
1549
2.02
2.16
27.4
14.2
23.31
22.05
mg/l
0.21
155
1244
39
251
1.70
2.12
1.8
1.7
1010.65
1142.28
nmol/l
0.47
28
201
0
56
0.00
2.10
0.0
1.1
—
0.60
—
0
8
163
1470
1.82
2.08
7.3
5.4
1.91
1.85
mu/l
0.23
150
1360
22
120
1.94
2.03
6.9
6.0
0.00
0.27
%
—
9
30
78
602
1.51
1.97
2.6
2.1
—
—
—
0
0
157
1407
1.70
1.97
7.6
5.9
39.87
38.82
mmol/mol
0.59
143
1330
6
16
3.84
1.95
1.2
1.3
—
—
—
0
0
6
16
3.84
1.95
8.7
4.9
26.00
24.19
nmol/l
—
6
16
7
22
3.26
1.90
1.0
1.2
—
—
—
0
0
7
22
3.26
1.90
1.4
1.2
—
—
—
0
0
14
66
2.21
1.87
1.4
1.5
—
—
—
0
0
42
285
1.61
1.87
3.5
2.5
2.46
2.44
mmol/l
0.38
35
252
58
428
1.51
1.79
1.5
1.4
0.69
1.89
u/ml
—
9
105
9
36
2.57
1.76
2.4
5.6
1.44
1.19
mmol/l
—
9
30
174
1621
1.99
1.71
32.2
18.2
73.24
73.35
umol/l
0.02
174
1599
21
120
1.84
1.70
6.8
5.7
0.00
0.18
%
—
8
33
141
1249
1.52
1.67
6.1
4.4
14.54
14.64
pmol/l
0.19
125
1144
6
19
3.23
1.67
1.0
1.3
—
—
—
0
0
11
49
2.32
1.67
1.7
3.2
—
—
—
0
0
22
129
1.80
1.65
6.5
5.5
0.56
0.99
%
—
9
42
5
14
3.64
1.62
1.0
1.3
2130.00
1608.93
ml
—
5
14
10
43
2.40
1.61
1.3
1.4
—
94.29
—
0
7
6
20
3.06
1.59
2.7
1.8
—
—
—
0
0
10
44
2.34
1.58
1.3
1.4
—
—
—
0
0
53
394
1.48
1.56
5.1
4.0
—
0.00
—
0
6
8
33
2.49
1.55
1.5
1.5
—
—
—
0
0
101
847
1.42
1.55
5.2
4.0
0.00
1.86
estimate
0.50
17
161
53
395
1.48
1.54
1.9
1.5
2.45
2.18
g/l
0.35
31
225
6
21
2.92
1.52
1.0
1.3
—
—
—
0
0
6
21
2.92
1.52
2.3
1.4
27.65
39.74
ng/l
—
6
21
10
45
2.29
1.49
1.5
1.2
—
—
—
0
0
99
833
1.40
1.47
5.1
4.0
0.00
0.00
estimate
-0.00
17
169
32
216
1.58
1.46
2.2
1.9
—
—
—
0
0
5
16
3.18
1.44
1.2
1.4
—
—
—
0
0
6
22
2.78
1.44
1.5
1.2
—
—
—
0
0
84
689
1.40
1.44
4.8
3.6
6.35
6.25
ph
0.24
36
388
15
82
1.90
1.40
1.5
1.7
—
—
—
0
0
6
23
2.66
1.38
1.2
1.0
—
—
—
0
0
5
17
2.99
1.36
1.2
1.9
—
—
—
0
0
61
477
1.41
1.36
1.3
1.6
—
—
—
0
0
99
840
1.38
1.36
5.2
4.0
0.00
9.61
estimate
0.50
17
169
34
238
1.52
1.33
3.1
2.3
70.50
114.07
ug/g
0.88
26
197
27
179
1.59
1.33
1.4
1.3
—
—
—
0
0
64
509
1.39
1.29
8.6
6.6
—
—
—
0
0
7
144
0.47
1.26
1.1
1.3
—
—
—
0
0
6
25
2.44
1.25
2.0
2.4
3.57
5.54
u/ml
—
6
25
89
751
1.35
1.23
15.3
10.6
0.00
0.00
e9/l
0.53
75
596
12
208
0.55
1.20
1.1
1.6
—
—
—
0
0
29
201
1.52
1.19
1.8
1.4
—
—
—
0
0
10
50
2.06
1.19
1.7
1.3
—
—
—
0
0
5
20
2.54
1.16
1.2
3.0
—
—
—
0
0
58
463
1.37
1.13
4.6
3.3
—
0.14
—
0
14
24
162
1.55
1.11
1.5
1.2
—
—
—
0
0
169
1595
1.59
1.10
19.0
12.5
—
—
—
0
0
5
22
2.31
1.04
1.0
1.1
—
—
—
0
0
59
479
1.34
1.02
5.0
4.0
7.97
13.41
mg/mmol
0.68
44
297
58
470
1.34
1.02
4.5
3.3
32.87
87.97
mg/l
1.74
44
314
7
35
2.04
1.01
1.1
1.4
1909.86
23519.92
e6/l
—
7
26
5
23
2.20
0.98
3.0
3.1
—
—
—
0
0
28
203
1.45
0.94
1.9
1.5
—
—
—
0
0
39
303
1.36
0.90
1.5
1.7
448.82
458.63
pmol/l
0.08
33
257
19
130
1.51
0.85
11.1
7.5
7.36
9.74
mmol/l
1.17
19
125
6
32
1.90
0.82
1.0
1.6
—
—
—
0
0
6
33
1.84
0.80
2.2
3.6
7.42
7.42
ph
—
6
33
11
67
1.68
0.77
1.4
1.2
—
—
—
0
0
9
55
1.67
0.74
1.2
1.1
—
—
—
0
0
7
38
1.87
0.74
1.9
1.4
—
—
—
0
0
10
60
1.70
0.73
1.9
1.2
—
—
—
0
0
54
455
1.26
0.70
4.5
3.9
0.00
0.00
estimate
-0.00
16
150
174
1679
1.49
0.69
39.2
22.3
7.21
6.70
e9/l
2.29
174
1642
174
1679
1.49
0.69
39.1
22.2
30.04
30.18
pg
0.42
174
1661
174
1679
1.49
0.69
39.2
22.3
4.43
4.47
e12/l
0.52
174
1643
174
1679
1.49
0.69
39.2
22.2
90.99
90.68
fl
0.34
174
1661
174
1679
1.49
0.69
39.9
22.6
39.76
40.06
%
0.36
174
1659
174
1679
1.49
0.69
38.8
22.3
256.51
254.69
e9/l
0.12
174
1651
18
128
1.45
0.68
1.7
1.5
—
—
—
0
0
174
1680
1.48
0.67
39.6
22.4
132.09
134.04
g/l
1.13
174
1661
36
290
1.30
0.66
1.4
1.4
1.70
9.66
u/ml
—
7
114
11
71
1.58
0.63
1.8
1.3
—
—
—
0
0
5
30
1.68
0.62
4.4
2.8
5.61
5.20
e9/l
—
5
30
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
38
314
1.26
0.58
1.4
1.3
30.27
38.71
iu/ml
—
6
103
9
59
1.55
0.56
2.9
1.5
—
—
—
0
0
26
207
1.30
0.53
1.3
1.3
—
—
—
0
0
9
65
1.40
0.51
1.4
1.5
—
—
—
0
0
155
1487
1.24
0.49
6.2
5.5
2.62
2.73
mmol/l
0.88
145
1389
145
1383
1.21
0.48
4.4
4.1
1.31
1.24
mmol/l
0.61
131
1283
7
48
1.48
0.47
3.7
3.0
1.40
1.59
mmol/l
—
7
48
11
77
1.46
0.46
1.8
1.3
—
—
—
0
0
72
651
1.17
0.45
2.0
1.9
1.40
1.34
mmol/l
0.28
64
558
10
69
1.47
0.45
2.2
2.1
—
—
—
0
0
11
78
1.44
0.44
1.8
1.3
—
—
—
0
0
11
78
1.44
0.44
1.8
1.3
—
—
—
0
0
11
79
1.42
0.41
1.8
1.3
—
—
—
0
0
5
33
1.53
0.41
2.4
2.4
56.40
58.68
%
—
5
33
13
171
0.74
0.41
2.4
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
3.86
—
0
5
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
23
189
1.25
0.38
3.4
3.0
0.68
0.76
ug/l
0.12
17
127
40
349
1.19
0.38
2.3
2.0
—
—
—
0
0
12
90
1.36
0.37
2.8
3.2
0.64
0.63
%
0.04
12
90
6
43
1.41
0.35
6.8
2.4
66.72
59.44
%
—
6
43
11
82
1.36
0.35
2.5
2.4
5099.52
8391.90
u/l
—
6
29
151
1460
1.17
0.34
6.3
4.7
6.02
5.86
mmol/l
0.56
140
1349
34
298
1.17
0.31
2.1
1.7
—
—
—
0
0
18
149
1.23
0.29
1.8
4.3
4.67
10.45
ug/l
0.89
12
119
12
94
1.30
0.29
2.8
3.2
1.28
1.25
%
0.08
12
94
151
1468
1.15
0.27
5.3
4.9
4.49
4.65
mmol/l
1.26
141
1378
5
75
0.66
0.26
1.0
1.1
—
—
—
0
0
9
73
1.24
0.26
2.6
2.3
—
—
—
0
0
35
315
1.14
0.23
5.8
5.5
1.85
3.01
ug/l
0.56
30
286
150
1462
1.13
0.23
5.2
4.8
1.44
1.50
mmol/l
0.78
138
1363
5
40
1.26
0.22
2.6
3.0
6.22
7.49
mmol/l
—
5
40
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
13
108
1.22
0.20
1.1
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
15
130
1.17
0.16
4.3
2.3
6.50
6.16
ph
—
7
97
43
456
0.93
0.13
4.7
3.3
0.00
0.19
estimate
0.52
13
135
40
376
1.08
0.13
7.9
5.4
—
—
—
0
0
60
622
0.95
0.09
5.0
3.8
0.00
0.00
estimate
-0.00
14
140
14
127
1.11
0.08
1.4
1.4
—
—
—
0
0
8
76
1.05
0.07
1.0
1.1
—
—
—
0
0
7
82
0.85
0.07
1.1
1.2
—
—
—
0
0
11
101
1.09
0.04
1.3
1.3
—
—
—
0
0
11
118
0.93
0.03
4.9
3.4
—
—
—
0
0
38
382
0.99
0.00
5.4
3.9
1.02
1.02
kg/l
0.39
26
257
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
21
210
1.00
-0.00
1.8
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
211.61
—
0
7
5
57
0.87
-0.00
1.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
28.7
—
178.27
—
0
6
5
59
0.84
-0.00
1.0
1.6
—
6.49
—
0
9
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
34.17
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.02
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
171.60
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_MILDVISIMPBINOC and mortality.

Females

Parameter HR [95% CI] p-value
H7_MILDVISIMPBINOC 1.814 [1.3, 2.54] < 0.001
Birth year 0.997 [0.99, 1.01] 0.541

During the follow-up period (1.1.1998 — 31.12.2019), 182 out of 791 females with H7_MILDVISIMPBINOC died.

Males

Parameter HR [95% CI] p-value
H7_MILDVISIMPBINOC 2.239 [1.54, 3.26] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 181 out of 685 males with H7_MILDVISIMPBINOC died.

Mortality risk

Mortality risk for people of age

years, who have H7_MILDVISIMPBINOC.

N-year risk Females Males
1 0.192% 0.38%
5 1.068% 2.285%
10 2.739% 5.686%
15 5.429% 11.097%
20 9.766% 18.066%

Relationships between endpoints

↥

Index endpoint: H7_MILDVISIMPBINOC – Mild or no visual impairment, binocular

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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