primary angle closure glaucoma: The sudden increase of intraocular pressure, resulting in pain and an abrupt decrease in visual acuity.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditionsNone |
519870 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1766 |
4. Check minimum number of eventsNone |
1766 |
5. Include endpointsNone |
1766 |
6. Filter based on genotype QC (FinnGen only) |
1702 |
Control definitions (FinnGen only)
- Control exclude
- H7_GLAUCOMA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H40
- Name in latin
- Glaucoma congestivum primarium
Similar endpoints
↥List of similar endpoints to
Primary angle-closure glaucoma
based on the number of shared cases.
Similar with more cases:
- Glaucoma
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17902 | 11851 | 5834 |
| Only index persons | 13200 | 8791 | 4409 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.34 | 0.16 |
| Only index persons | 0.27 | 0.32 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 68.78 | 69.73 | 66.90 |
| Only index persons | 67.76 | 68.71 | 65.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1702 | 1000 | 702 |
| Unadjusted period prevalence (%) | 0.34 | 0.36 | 0.32 |
| Median age at first event (years) | 66.83 | 66.57 | 67.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1766
- Matched controls
- 17660
TimeCodeWAS
↥TODO / Current known limitations:
- Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
- Legend / how to read the glyphs.
- Proper column names.
- Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
- Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
- Download CSV not working.
- No filters and sorters.
- Limited amount of endpoints with TimeCodeWAS data.
- Cross-links to Risteys lab test pages for lab test codes.
H40.2 (45557422)
H40.5 (45571978)
H40.10 (2000502332)
H40.11 (2000502333)
H40.12 (2000502334)
H40.20 (2000502337)
H40.21 (2000502338)
H40.22 (2000502339)
CHD15 (2001301267)
H40.8 (45547897)
H40.29 (2000502340)
CHD05 (2001301265)
H40.9 (45547899)
37511 (2000302415)
3652B (2000403287)
H40.13 (2000502335)
CHC05 (2001301259)
CHD00 (2001301264)
CHD65 (2001301279)
CHF05 (2001301292)
XCH05 (2001311083)
SMOKING-2-2-0 (2002330110)
SMOKING-1-1-0 (2002330116)
S01EA03 (21603675)
S01EA05 (21603677)
S01GA07 (947915)
3652A (2000403286)
H04.10 (2000502254)
CHD50 (2001301275)
CHD99 (2001301281)
XCK00 (2001301380)
CKD65 (2001301417)
CS3P4 (2001301474)
CS434 (2001301476)
CS5Z4 (2001301479)
SMOKING-2-3-0 (2002330113)
SMOKING-2-3-5 (2002330114)
S01EB01 (21603680)
S01EB51 (21603690)
50373000 (4177340)
391999003 (4189584)
392005004 (4194118)
60621009 (4245997)
H40 (45547879)
H40.0 (45567051)
700070005 (45763633)
37500 (2000302413)
H35.30 (2000502314)
XCH00 (2001301234)
CJB10 (2001301313)
CJE20 (2001301342)
XCK10 (2001301381)
CK2S4 (2001301455)
CS444 (2001301477)
CS494 (2001301478)
XCW99 (2001301491)
WX100 (2001310764)
WX140 (2001310772)
ZXA00 (2001311346)
ZXA10 (2001311348)
ZXD20 (2001311388)
Z3229 (2001311561)
114 (2001600114)
S01AA20 (21603571)
S01BA01 (21603618)
S01BA04 (21603621)
S01EC01 (21603693)
S01EC03 (21603695)
S01EC04 (21603696)
S01ED02 (21603700)
S01ED51 (21603705)
S01EE01 (21603710)
S01EE03 (21603712)
S01EE04 (21603713)
S03BA01 (21605201)
S03BA02 (21605202)
19926-5 (3011505)
19870-5 (3020158)
20150-9 (3024653)
S01AE05 (43534860)
H20.0 (45542994)
H52.0 (45543078)
H20.1 (45562191)
H25.0 (45576699)
H25.1 (45581628)
Z96.1 (45585885)
H57.1 (45596140)
H25.8 (45605644)
S01EC54 (45893490)
18 (38004463)
S01ED01 (21603699)
S01EE05 (21603714)
Z01.0 (45566391)
CK2X4 (2001301456)
E10.7 (45571655)
OP (9202)
ER (9203)
S01BA07 (21603624)
H34.8 (45547863)
OMOP5117446 (33004)
ZXA05 (2001311347)
21 (8717)
S01KA02 (21605115)
22 (8756)
S01CA01 (21603652)
ZXE00 (2001311394)
93 (38004510)
WX002 (2001310758)
S01BC10 (21603648)
Z2221 (2001311556)
A01AC02 (21600035)
C05AA09 (21601613)
D07AB19 (21602116)
D10AA03 (21602286)
S02BA06 (21605168)
13 (38004458)
ZXD10 (2001311387)
OMOP4822462 (581458)
ZXC20 (2001311366)
H40.1 (45533312)
S01AA01 (21603554)
S03AA08 (21605197)
715-3 (3021589)
251B00000X (38004193)
S01BC03 (21603641)
1 (38004446)
14749-6 (3013826)
Z71.8 (45581061)
58435-9 (40761536)
OMOP4822458 (581477)
I10 (45591453)
11 (38004456)
WX110 (2001310767)
IP (9201)
2951-2 (3019550)
2823-3 (3023103)
S01BC05 (21603643)
1988-5 (3020460)
62238-1 (40764999)
14682-9 (3020564)
58410-2 (40761511)
26464-8 (3010813)
26453-1 (3026361)
26515-7 (3007461)
20570-8 (3009542)
718-7 (3000963)
28539-5 (3035941)
30428-7 (3024731)
30385-9 (3002385)
28540-3 (3003338)
19875-4 (3001668)
20155-8 (3023550)
69970-2 (42868459)
69982-7 (42868471)
69983-5 (42868472)
WX006 (2001310762)
OMOP4822461 (32036)
H26.4 (45600893)
GD1AA (2001303617)
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCCLOSEPRIM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCCLOSEPRIM | 1.071 [0.99, 1.16] | 0.085 |
| Birth year | 0.992 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 2692 out of 7308 females with H7_GLAUCCLOSEPRIM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCCLOSEPRIM | 1.093 [0.98, 1.22] | 0.115 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1312 out of 3811 males with H7_GLAUCCLOSEPRIM died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCCLOSEPRIM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.064% | 0.193% |
| 5 | 0.526% | 1.222% |
| 10 | 1.319% | 3.23% |
| 15 | 2.475% | 5.968% |
| 20 | 4.646% | 9.811% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCCLOSEPRIM – Primary angle-closure glaucoma
GWS hits: 1