Observable characteristics or traits involving the accumulation of pigmented material or deposits on the cornea, the transparent front part of the eye.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
170 |
4. Check minimum number of eventsNone |
170 |
5. Include endpointsNone |
170 |
6. Filter based on genotype QC (FinnGen only) |
146 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Pigmentationes et alia deposita corneae
Similar endpoints
↥List of similar endpoints to
Corneal pigmentations and deposits
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1538 | 814 | 709 |
| Only index persons | 1121 | 568 | 553 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.64 | 54.96 | 45.56 |
| Only index persons | 44.59 | 47.91 | 41.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 146 | 82 | 64 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 48.10 | 48.83 | 47.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 153
- Matched controls
- 1530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
124.6
102
*
H16.0
ICD-10 Finland
Corneal ulcer
29.4
53.5
38
17
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
50.9
46
*
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
23.5
22
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.8
19.4
104
470
H04.10
ICD-10 Finland
Dry eye syndrome
5.6
18.5
43
100
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
18.1
17
*
S01AD03
ATC
aciclovir; ophthalmic
17.3
16.0
25
17
H18.6
ICD-10 Finland
Keratoconus
+∞
15.9
15
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
13.7
13
*
H16.9
ICD-10 Finland
Keratitis, unspecified
76.4
12.8
14
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
12.7
12
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
141.1
12.6
13
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
117.8
10.6
11
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
117.8
10.6
11
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
10.5
10
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.6
10.1
41
142
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.0
9.9
77
391
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.3
9.7
28
76
S01ED01
ATC
timolol; ophthalmic
8.3
9.3
20
27
TCG10
NOMESCO Finland
Removal of sutures from cornea
+∞
8.4
8
*
XCK10
NOMESCO Finland
Photography of fundus of eye
3.8
8.3
28
85
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.4
8.2
33
113
L04AA01
ATC
[U] ciclosporin
23.5
8.1
11
5
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.0
8.1
25
71
S01BA01
ATC
dexamethasone; ophthalmic
8.4
7.6
16
21
WX140
NOMESCO Finland
Parabulbar anesthesy
6.4
7.5
19
33
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
84.0
7.5
8
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
7.3
7
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
7.3
7
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
+∞
7.3
7
*
H26.4
ICD-10 Finland
After-cataract
3.4
7.3
29
98
S01BA04
ATC
prednisolone; ophthalmic
12.9
7.2
12
10
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.5
6.9
26
85
C01BD01
ATC
amiodarone; systemic
8.4
6.8
14
18
S01AA12
ATC
tobramycin; ophthalmic
23.7
6.8
9
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
6.7
40
171
ZXA05
NOMESCO Finland
Left side
2.6
6.4
50
244
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
19.0
6.3
9
5
3604
FHL
Penetration of the cornea
+∞
6.3
6
*
H18.4
ICD-10 Finland
Corneal degeneration
+∞
6.3
6
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
6.3
6
*
36399
ICD-8 Finland
Keratitis, Without mention of ulcer
+∞
6.3
6
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
6.3
6
*
S01AX11
ATC
[U] ofloxacin
5.7
6.2
17
33
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
48
292
1.94
3.34
4.0
4.2
1.02
1.02
kg/l
0.41
32
185
7
12
6.05
3.05
1.6
1.3
—
—
—
0
0
90
684
1.77
2.95
4.3
4.1
0.00
0.00
estimate
-0.00
15
154
6
10
6.19
2.72
1.2
1.2
—
—
—
0
0
89
690
1.69
2.58
4.4
4.1
0.13
10.34
estimate
0.49
15
157
71
523
1.67
2.47
4.1
4.2
0.38
0.02
estimate
0.72
13
124
89
699
1.65
2.38
4.4
4.1
0.00
0.00
estimate
-0.00
14
142
50
341
1.69
2.29
3.4
2.2
2.86
3.00
mg/l
0.18
45
309
58
417
1.63
2.16
3.9
4.2
30.24
11.69
mg/mmol
0.51
38
263
33
205
1.78
2.09
3.3
2.6
24.60
22.62
%
0.38
33
195
74
591
1.49
1.63
3.6
3.0
113.13
118.18
ug/l
0.13
74
554
26
165
1.69
1.53
1.8
1.7
—
—
—
0
0
36
252
1.56
1.44
3.1
4.0
13.86
254.14
ng/l
1.42
29
209
17
97
1.85
1.42
3.1
3.1
53.29
64.98
ml/min/173m2
—
7
43
66
529
1.44
1.37
4.9
4.1
34.98
48.13
ng/l
0.44
53
380
0
38
0.00
1.36
0.0
1.8
—
3.15
—
0
31
25
163
1.64
1.34
1.8
1.7
—
—
—
0
0
46
347
1.47
1.30
1.9
3.0
339.88
347.57
umol/l
0.16
41
309
20
124
1.71
1.28
10.2
8.7
—
—
—
0
0
13
72
1.88
1.19
1.7
1.2
—
—
—
0
0
78
660
1.37
1.12
6.8
6.9
1.22
1.21
mmol/l
0.37
68
570
8
41
2.00
1.10
1.9
1.6
—
—
—
0
0
125
1149
1.48
1.06
6.3
5.4
1.84
1.93
mu/l
0.51
119
1070
30
217
1.48
1.04
1.6
1.8
1327.22
1259.74
nmol/l
0.16
23
166
5
22
2.31
1.04
1.0
1.3
—
—
—
0
0
32
237
1.44
0.99
4.2
2.9
2.96
0.79
e6/l
0.77
23
124
129
1203
1.46
0.91
5.8
5.1
6.20
5.97
mmol/l
0.82
117
1107
8
44
1.86
0.87
1.4
1.3
—
—
—
0
0
131
1233
1.43
0.80
24.2
16.6
21.84
23.15
mg/l
0.23
114
1025
48
395
1.31
0.78
3.8
3.7
0.10
0.01
estimate
—
10
119
113
1042
1.32
0.77
29.5
20.7
13.64
13.70
%
0.21
113
1034
29
223
1.37
0.74
4.2
3.0
4.55
3.08
e6/l
0.26
20
109
5
25
2.03
0.73
1.2
1.0
—
—
—
0
0
5
26
1.95
0.71
2.2
3.6
16.04
9.48
pmol/l
—
5
26
29
225
1.36
0.70
1.7
1.9
—
—
—
0
0
66
574
1.26
0.70
2.5
2.1
92.28
99.17
pmol/l
0.80
44
286
17
120
1.47
0.68
6.7
7.4
1.51
1.36
mmol/l
0.35
17
120
5
28
1.81
0.67
1.0
1.4
—
—
—
0
0
133
1266
1.39
0.64
30.0
19.4
4.01
3.99
mmol/l
0.20
133
1244
46
387
1.27
0.63
2.0
1.7
21.45
21.55
nmol/l
0.01
40
329
83
750
1.23
0.60
12.7
9.9
4.34
4.18
e9/l
0.26
74
657
12
82
1.50
0.56
7.3
8.3
24.79
25.04
mmol/l
0.07
12
82
55
480
1.23
0.54
4.4
3.2
—
—
—
0
0
123
1166
1.28
0.54
8.0
6.7
40.26
39.75
mmol/mol
0.23
118
1103
7
45
1.58
0.49
1.6
1.4
—
—
—
0
0
7
48
1.48
0.47
3.9
2.6
—
—
—
0
0
132
1268
1.30
0.47
29.3
19.3
139.45
139.65
mmol/l
0.46
132
1249
24
195
1.27
0.44
7.0
7.0
105.29
103.48
mmol/l
1.10
24
195
5
32
1.58
0.42
1.0
1.4
—
—
—
0
0
38
328
1.21
0.41
4.7
4.6
22.88
22.28
%
0.07
21
160
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
2.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
9
66
1.39
0.39
1.2
1.3
—
—
—
0
0
135
1307
1.28
0.39
32.2
21.3
83.63
78.87
umol/l
0.59
135
1295
6
46
1.32
0.33
1.8
1.5
—
—
—
0
0
122
1176
1.18
0.32
4.5
4.2
1.55
1.28
mmol/l
0.65
112
1080
128
1239
1.20
0.32
6.5
5.8
2.47
2.68
mmol/l
2.00
121
1153
44
395
1.16
0.31
4.6
4.1
0.00
0.02
estimate
0.50
12
137
43
386
1.16
0.30
4.2
3.0
0.78
0.42
e6/l
0.25
34
269
19
159
1.22
0.28
6.5
8.0
4.94
5.12
kpa
0.63
19
153
19
159
1.22
0.28
6.4
8.0
11.79
12.21
kpa
0.14
19
154
65
604
1.13
0.28
4.1
2.7
—
—
estimate
—
0
0
14
114
1.25
0.26
1.9
1.6
—
—
—
0
0
126
1226
1.16
0.24
5.5
5.1
4.46
4.60
mmol/l
0.71
119
1145
136
1331
1.20
0.23
35.3
25.3
257.27
245.99
e9/l
1.33
136
1314
5
39
1.29
0.23
1.0
1.2
—
—
—
0
0
5
39
1.29
0.23
1.2
1.3
—
1.75
—
0
8
10
79
1.28
0.23
1.7
2.7
0.68
0.64
%
—
10
79
136
1332
1.19
0.22
36.4
25.7
39.32
40.18
%
1.10
136
1323
136
1332
1.19
0.22
35.8
25.2
4.35
4.48
e12/l
2.36
136
1307
136
1332
1.19
0.22
35.8
25.2
91.35
91.15
fl
0.20
136
1323
5
41
1.23
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.6
—
0.80
—
0
10
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
10
123
0.80
0.21
1.5
2.3
—
—
—
0
0
136
1333
1.18
0.21
36.2
25.4
131.68
134.76
g/l
1.61
136
1323
48
446
1.11
0.20
4.1
3.4
1514.77
1093.43
ng/l
0.30
43
373
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
1.27
—
0
5
6
52
1.16
0.19
1.0
1.7
35.67
40.17
u/l
—
6
44
10
81
1.25
0.19
1.7
2.7
1.09
1.42
%
—
10
81
11
92
1.21
0.16
7.9
9.4
0.79
0.67
%
0.37
11
92
9
80
1.13
0.15
2.7
1.6
—
—
—
0
0
79
764
1.07
0.12
2.8
3.1
—
—
—
0
0
21
229
0.90
0.11
1.5
1.3
2.04
9.61
u/ml
1.40
12
87
11
96
1.16
0.10
5.5
9.2
1.37
1.43
%
0.08
11
96
5
43
1.17
0.10
1.0
1.5
—
—
—
0
0
5
43
1.17
0.10
1.0
1.5
—
—
—
0
0
12
107
1.13
0.09
1.3
1.4
—
—
—
0
0
6
57
1.05
0.08
1.7
2.4
—
—
—
0
0
12
133
0.89
0.08
1.7
2.5
—
—
—
0
0
6
71
0.84
0.08
1.0
1.1
—
—
—
0
0
34
324
1.06
0.07
1.5
1.3
0.52
1.47
u/ml
—
9
88
13
119
1.10
0.06
3.3
2.6
0.25
0.21
g/l
0.66
13
109
29
277
1.06
0.06
3.3
2.9
2.44
2.45
mmol/l
0.47
29
251
11
100
1.11
0.05
1.1
2.8
68.60
66.08
g/l
0.67
11
94
17
181
0.93
0.05
1.6
1.5
—
—
—
0
0
21
200
1.06
0.04
1.4
1.6
—
—
—
0
0
25
242
1.04
0.02
13.7
2.8
0.79
0.81
mmol/l
0.36
25
229
123
1222
1.03
0.02
5.3
4.9
1.46
1.46
mmol/l
0.05
116
1134
27
263
1.03
0.01
2.9
3.0
0.69
0.80
ug/l
0.45
18
162
30
307
0.97
0.01
4.7
2.3
—
—
—
0
0
51
517
0.98
0.01
2.2
2.0
1.39
1.35
mmol/l
0.09
43
443
25
244
1.03
0.00
1.3
1.3
16.26
27.13
iu/ml
0.98
11
84
14
142
0.98
0.00
2.8
3.8
—
—
—
0
0
0
8
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
1621.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.6
—
4.62
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.6
—
9.96
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
42.58
—
0
6
5
55
0.91
-0.00
2.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
34.93
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.6
—
226.20
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.30
—
0
5
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEAPIGMENT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEAPIGMENT | 1.511 [1.03, 2.21] | 0.033 |
| Birth year | 0.996 [0.99, 1.0] | 0.39 |
During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 385 females with H7_CORNEAPIGMENT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEAPIGMENT | 1.17 [0.8, 1.7] | 0.413 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 373 males with H7_CORNEAPIGMENT died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEAPIGMENT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.182% | 0.23% |
| 5 | 0.941% | 1.32% |
| 10 | 2.26% | 3.36% |
| 15 | 4.493% | 6.568% |
| 20 | 7.991% | 11.156% |
Relationships between endpoints
↥Index endpoint: H7_CORNEAPIGMENT – Corneal pigmentations and deposits
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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