No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1194 |
4. Check minimum number of eventsNone |
1194 |
5. Include endpointsNone |
1194 |
6. Filter based on genotype QC (FinnGen only) |
1081 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H15-H22
- Name in latin
- Cicatrices et opacitates corneae
Similar endpoints
↥List of similar endpoints to
Corneal scars and opacities
based on the number of shared cases.
Similar with more cases:
- Keratitis
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7698 | 3908 | 3727 |
| Only index persons | 6810 | 3444 | 3366 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.11 | 0.10 |
| Only index persons | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 61.16 | 67.07 | 54.84 |
| Only index persons | 59.45 | 65.16 | 53.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1081 | 570 | 511 |
| Unadjusted period prevalence (%) | 0.22 | 0.20 | 0.23 |
| Median age at first event (years) | 61.26 | 61.02 | 61.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1129
- Matched controls
- 11290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
307.7
339
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
7103.6
307.7
453
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
307.7
342
*
H16.0
ICD-10 Finland
Corneal ulcer
50.1
307.7
286
76
CG2T4
NOMESCO Finland
Topography assessment of cornea
133.0
278.1
140
12
S01AD03
ATC
aciclovir; ophthalmic
16.7
189.8
167
116
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
6.2
181.8
824
3419
H16.9
ICD-10 Finland
Keratitis, unspecified
273.7
164.1
164
7
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.3
147.6
302
619
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.9
124.2
353
954
CG2S4
NOMESCO Finland
Photography of cornea
255.7
114.0
115
5
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
113.5
107
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
248.3
110.9
112
5
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
177.4
108.4
112
7
H04.10
ICD-10 Finland
Dry eye syndrome
5.0
106.4
273
671
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
104.9
99
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.7
104.6
596
2597
XCK10
NOMESCO Finland
Photography of fundus of eye
5.1
96.1
236
556
H18.4
ICD-10 Finland
Corneal degeneration
893.4
85.8
83
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.1
82.1
275
819
H17.0
ICD-10 Finland
Adherent leukoma
+∞
78.0
74
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
789.4
76.2
74
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
74.8
71
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
20.6
74.3
57
29
S01ED01
ATC
timolol; ophthalmic
8.1
72.7
102
137
WX140
NOMESCO Finland
Parabulbar anesthesy
6.1
72.4
134
242
H18.8
ICD-10 Finland
Other specified disorders of cornea
252.3
70.1
71
*
CD2S4
NOMESCO Finland
Photography of eye
22.2
68.6
51
24
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.1
65.4
209
595
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
63.3
324
1253
TCG10
NOMESCO Finland
Removal of sutures from cornea
91.8
62.7
69
8
Z3229
NOMESCO Finland
Other healthcare associate professional
4.1
60.0
184
507
S01BA07
ATC
fluorometholone; ophthalmic
12.7
57.7
57
47
S01XA18
ATC
ciclosporin; ophthalmic
23.1
52.0
38
17
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
67.8
50.7
58
9
S01ED51
ATC
timolol, combinations; ophthalmic
4.0
50.4
157
435
H16.2
ICD-10 Finland
Keratoconjunctivitis
136.1
49.2
52
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.5
47.3
476
2551
S01BC03
ATC
diclofenac; ophthalmic
8.1
45.9
63
82
ZXA10
NOMESCO Finland
Bilateral
2.8
45.3
299
1303
S01EA05
ATC
brimonidine; ophthalmic
7.1
44.9
69
102
H25.1
ICD-10 Finland
Senile nuclear cataract
2.5
44.3
416
2146
3710A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal scars and opacities
+∞
44.0
42
*
S01BA04
ATC
prednisolone; ophthalmic
9.0
41.6
52
60
H26.2
ICD-10 Finland
Complicated cataract
12.1
41.4
42
36
L04AA01
ATC
[U] ciclosporin
12.1
40.5
41
35
H11.0
ICD-10 Finland
Pterygium
13.0
40.2
39
31
H57.1
ICD-10 Finland
Ocular pain
5.4
39.9
81
158
H17
ICD-10 Finland
Corneal scars and opacities
+∞
39.8
38
*
H52.2
ICD-10 Finland
Astigmatism
7.1
39.3
60
88
H18.6
ICD-10 Finland
Keratoconus
390.1
38.3
38
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
36.7
35
*
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
13.0
35.0
34
27
H16.8
ICD-10 Finland
Other keratitis
185.7
34.9
36
*
S01EC01
ATC
acetazolamide; systemic
6.8
34.7
55
84
CGE10
NOMESCO Finland
Keratectomy
+∞
34.6
33
*
S01BA01
ATC
dexamethasone; ophthalmic
5.2
34.2
72
145
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.2
33.0
148
515
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
76.6
33.0
37
5
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.6
32.8
114
338
XCK00
NOMESCO Finland
Perimetry
3.7
31.8
108
315
S01EE01
ATC
latanoprost; ophthalmic
3.5
30.6
115
359
H19.2*B02.3
ICD-10 Finland
Keratitis and keratoconjunctivitis (interstitial) in zoster
+∞
30.3
29
*
H27.0
ICD-10 Finland
Aphakia
38.2
29.4
37
10
T15.0
ICD-10 Finland
Foreign body in cornea
4.7
29.3
70
157
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
29.3
28
*
WX002
NOMESCO Finland
Sedation and analgesia
2.3
29.3
272
1360
H18.1
ICD-10 Finland
Bullous keratopathy
299.3
28.9
29
*
H26.4
ICD-10 Finland
After-cataract
2.7
27.9
163
654
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
288.4
27.9
28
*
S01EA03
ATC
apraclonidine; ophthalmic
9.9
26.9
31
32
CFD10
NOMESCO Finland
Repair of conjunctiva
47.0
26.6
32
7
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
26.1
25
*
3604
FHL
Penetration of the cornea
+∞
26.1
25
*
S01AA01
ATC
chloramphenicol; ophthalmic
3.7
25.6
84
239
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
3.1
25.4
113
390
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.2
25.3
105
348
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
255.5
24.8
25
*
ZXA00
NOMESCO Finland
Right side
2.0
24.7
346
2014
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.1
24.3
107
367
J05AB11
ATC
valaciclovir; oral
2.4
24.2
202
957
Z3231
NOMESCO Finland
Registered nurse
2.0
23.4
348
2062
114
Kela drug reimbursment
Glaucoma
2.7
23.1
134
534
H16.3
ICD-10 Finland
Interstitial and deep keratitis
+∞
23.0
22
*
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
22.9
250
1321
ZXE00
NOMESCO Finland
One hour or less
1.9
22.1
462
3052
CGF10
NOMESCO Finland
Suture of laceration of cornea
+∞
21.9
21
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
224.2
21.7
22
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
21.6
448
2948
ZXA05
NOMESCO Finland
Left side
2.0
21.4
310
1811
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
5.0
21.0
46
96
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
20.9
20
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
4.2
20.8
56
138
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
112.1
20.6
22
*
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
5.0
20.3
44
91
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
19.8
19
*
H18.2
ICD-10 Finland
Other corneal oedema
+∞
19.8
19
*
J05AB01
ATC
aciclovir; systemic
2.0
19.6
269
1536
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
106.9
19.6
21
*
W44
ICD-10 Finland
Foreign body entering into or through eye or natural orifice
5.7
19.2
36
65
H01.0
ICD-10 Finland
Blepharitis
2.8
19.2
102
388
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
7.7
19.2
27
36
XCH00
NOMESCO Finland
Eye pressure measurement
3.2
19.0
77
251
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
35.0
18.9
24
7
127
Kela drug reimbursment
Transplant complication
5.8
18.6
34
60
F01
ICPC
Eye pain
4.3
18.2
47
112
S01AX11
ATC
[U] ofloxacin
3.8
18.2
57
157
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
17.8
17
*
ZXD20
NOMESCO Finland
Day surgery
2.2
17.7
171
855
H20.8
ICD-10 Finland
Other iridocyclitis
182.8
17.6
18
*
H02.1
ICD-10 Finland
Ectropion of eyelid
6.9
17.5
27
40
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
7.2
17.4
26
37
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
14.3
16.8
28
20
CGF35
NOMESCO Finland
Repair of cornea using graft
+∞
16.7
16
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
16.7
16
*
CBH25
NOMESCO Finland
Tarsorrhaphy
+∞
16.7
16
*
L01BA01
ATC
methotrexate; systemic
3.8
16.7
51
138
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.6
16.6
102
417
S01BC05
ATC
ketorolac; ophthalmic
3.4
16.6
60
182
S01FA04
ATC
cyclopentolate; ophthalmic
14.5
16.4
27
19
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
48.2
16.1
19
*
B00.5
ICD-10 Finland
Herpesviral ocular disease
33.9
15.8
20
6
CBH30
NOMESCO Finland
Tarsorraphy
+∞
15.7
15
*
CGE16
NOMESCO Finland
Destruction of lesion of cornea
+∞
15.7
15
*
H10.4
ICD-10 Finland
Chronic conjunctivitis
6.3
15.5
26
42
S01EC04
ATC
brinzolamide; ophthalmic
3.2
15.5
63
206
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
6.5
15.4
25
39
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
15.1
164
855
H43.1
ICD-10 Finland
Vitreous haemorrhage
4.2
15.0
40
98
F29
ICPC
Eye symptom/complaint other
2.2
15.0
134
648
XCD10
NOMESCO Finland
Electrophysiological examination of eye
4.2
14.8
40
99
H40.0
ICD-10 Finland
Glaucoma suspect
2.4
14.7
107
474
H18.7
ICD-10 Finland
Other corneal deformities
+∞
14.6
14
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
14.5
407
2843
H18.3
ICD-10 Finland
Changes in corneal membranes
151.9
14.5
15
*
Z2221
NOMESCO Finland
Medical doctor
1.7
14.4
312
2030
H02.2
ICD-10 Finland
Lagophthalmos
17.2
14.3
22
13
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
6.5
14.1
23
36
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
43.1
14.1
17
*
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
30.4
13.9
18
6
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.2
13.7
36
87
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
13.6
13
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
13.6
13
*
CGC10
NOMESCO Finland
Removal of foreign body from cornea
13.0
13.4
23
18
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
13.2
292
1906
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
12.6
546
4200
S01EC54
ATC
brinzolamide, combinations; ophthalmic
5.4
12.3
24
45
S01EC03
ATC
dorzolamide; ophthalmic
5.0
12.2
26
53
J01DB01
ATC
cefalexin; oral
1.8
12.2
913
7984
H15.1
ICD-10 Finland
Episcleritis
13.5
12.0
20
15
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
11.9
95
437
H25.0
ICD-10 Finland
Senile incipient cataract
2.4
11.9
83
360
CKD60
NOMESCO Finland
Anterior vitrectomy
9.1
11.8
24
27
H02AB06
ATC
prednisolone; systemic
1.6
11.6
519
3996
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
65.6
11.6
13
*
CGE55
NOMESCO Finland
Excision of pterygium with transplanation of conjunctiva
19.2
11.6
17
9
CHC05
NOMESCO Finland
Iridotomy
4.9
11.5
25
52
S01FA02
ATC
scopolamine; ophthalmic
15.2
11.3
18
12
L04AD01
ATC
ciclosporin; systemic
4.3
11.3
29
69
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
4.8
11.2
25
53
H52.1
ICD-10 Finland
Myopia
3.1
11.2
48
162
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
20.3
11.1
16
8
R4110
NOMESCO Finland
Physiotherapy
1.6
10.9
313
2171
S01EE05
ATC
tafluprost; ophthalmic
2.8
10.7
52
189
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
10.5
158
917
S01EX03, ,
ATC
3.8
10.5
32
87
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
111.0
10.4
11
*
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
10.4
10
*
H21.0
ICD-10 Finland
Hyphaema
+∞
10.4
10
*
36400
ICD-8 Finland
Iritis, Iridocyclitis acuta
+∞
10.4
10
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
10.4
469
3594
H25.8
ICD-10 Finland
Other senile cataract
1.9
10.2
129
707
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
13.3
10.2
17
13
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.7
10.1
32
89
A12AA04
ATC
calcium carbonate; oral
4.3
10.1
26
62
WX142
NOMESCO Finland
Sub-tenon anesthesy
8.0
10.1
22
28
TQW40
NOMESCO Finland
Remowal of suture of skin
2.2
10.1
85
400
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.7
10.1
52
195
S01FA01
ATC
atropine; ophthalmic
14.7
10.0
16
11
S01AA12
ATC
tobramycin; ophthalmic
20.2
9.8
14
7
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.0
9.7
113
603
S05.2
ICD-10 Finland
Ocular laceration and rupture with prolapse or loss of intraocular tissue
55.5
9.7
11
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.1
9.6
40
133
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
4.5
9.6
23
52
CF2S4
NOMESCO Finland
Photography of conjunctiva
30.3
9.4
12
*
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
+∞
9.4
9
*
36399
ICD-8 Finland
Keratitis, Without mention of ulcer
+∞
9.4
9
*
H22.0*B00.5
ICD-10 Finland
Herpesviral iridocyclitis
+∞
9.4
9
*
E85.80
ICD-10 Finland
Meretoja sick
+∞
9.4
9
*
37403
ICD-8 Finland
Cataract, Complicata
+∞
9.4
9
*
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.6
9.3
22
49
L28
ICPC
Limited function/disability (L)
1.6
9.3
218
1431
H3603, E103,
ICD-10 Finland
8.4
9.1
19
23
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
10.1
9.0
17
17
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
37.0
9.0
11
*
H16
ICD-10 Finland
Keratitis
37.0
9.0
11
*
TK800
NOMESCO Finland
Hemodialysis
3.4
8.9
31
92
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
24.2
8.9
12
5
H02.4
ICD-10 Finland
Ptosis of eyelid
2.8
8.9
43
156
D11AX14
ATC
[U] tacrolimus
12.6
8.9
15
12
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
3.3
8.8
33
103
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.6
8.7
50
198
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.2
8.7
34
109
S05.3
ICD-10 Finland
Ocular laceration without prolapse or loss of intraocular tissue
50.4
8.7
10
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
50.4
8.7
10
*
L04AX01
ATC
azathioprine; systemic
2.6
8.7
49
193
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
8.6
766
6624
H10
ICD-10 Finland
Conjunctivitis
2.1
8.5
78
380
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
8.5
394
3003
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
8.5
96
506
C01BD01
ATC
amiodarone; systemic
2.9
8.5
40
143
3661A
ICD-9 Finland
Cataract, Senile cataract
7.4
8.5
19
26
L04AA06
ATC
mycophenolic acid; systemic
3.6
8.4
27
76
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
90.7
8.4
9
*
A02BC02
ATC
pantoprazole; systemic
1.5
8.4
734
6307
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
6.8
8.4
20
30
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
4.0
8.4
23
58
3700A
ICD-9 Finland
Keratitis, Corneal ulcer
+∞
8.3
8
*
3716A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Keratoconus
+∞
8.3
8
*
H15.0
ICD-10 Finland
Scleritis
+∞
8.3
8
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.6
8.3
46
179
A11CC03
ATC
alfacalcidol; systemic
3.2
8.1
32
103
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.3
8.1
60
268
CGE50
NOMESCO Finland
Excision of pterygium
33.6
8.1
10
*
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
22.2
8.0
11
5
Z2446
NOMESCO Finland
Social worker
2.1
8.0
77
383
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.2
8.0
31
99
Z2445
NOMESCO Finland
Psychologist
2.6
8.0
45
177
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
7.8
7.9
17
22
Z71.8
ICD-10 Finland
Other specified counselling
1.5
7.9
351
2647
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
7.9
113
645
A10AB01
ATC
insulin (human); parenteral
2.6
7.8
43
167
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
7.8
212
1437
Z49.1
ICD-10 Finland
Extracorporeal dialysis
4.1
7.8
21
52
H54.0
ICD-10 Finland
Blindness, binocular
45.3
7.7
9
*
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
45.3
7.7
9
*
CBG99
NOMESCO Finland
Other operation for trichiasis
45.3
7.7
9
*
37404
ICD-8 Finland
Cataract, Secundaria
45.3
7.7
9
*
C03CA01
ATC
furosemide; systemic
1.5
7.7
331
2478
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
25.2
7.6
10
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
3.5
7.6
25
72
F02
ICPC
Red eye
2.4
7.6
51
219
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
3.8
7.5
22
58
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
10.1
7.5
14
14
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
7.5
431
3402
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
7.5
356
2713
E0000UV, ,
ATC
1.4
7.5
433
3422
D11AH01
ATC
tacrolimus; topical
7.2
7.5
17
24
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
7.5
405
3163
H19.2
ICD-10 Finland
Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
80.6
7.4
8
*
37520
ICD-8 Finland
Glaucoma, Secondary
80.6
7.4
8
*
CGD99
NOMESCO Finland
Other operation for error of refraction
80.6
7.4
8
*
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.4
455
3634
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.4
7.4
26
78
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
4.1
7.4
20
50
N18.8
ICD-10 Finland
Other chronic renal failure
3.1
7.4
30
99
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.1
7.3
71
354
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.1
7.3
29
94
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
7.3
7
*
3651
FHL
Penetrating corneal transplantation and cataract surgery
+∞
7.3
7
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.0
7.3
74
376
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.3
7.3
27
84
J01MA02
ATC
ciprofloxacin; systemic
1.4
7.3
400
3131
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
30.2
7.2
9
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
20.2
7.1
10
5
R55
ICD-10 Finland
Syncope and collapse
1.7
7.1
123
742
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
6.1
7.1
18
30
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
12.1
7.1
12
10
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
7.0
7.0
16
23
S01ED02
ATC
betaxolol; ophthalmic
4.4
7.0
17
39
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
3.0
7.0
29
97
H54.4
ICD-10 Finland
Blindness, monocular
13.9
6.9
11
8
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.0
6.9
74
384
S01KA02
ATC
hypromellose; ophthalmic
3.5
6.9
23
67
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.2
6.8
57
269
R42
ICD-10 Finland
Dizziness and giddiness
1.5
6.8
246
1774
Z97.0
ICD-10 Finland
Presence of artificial eye
40.3
6.8
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.6
6.7
186
1264
S29
ICPC
Skin symptom/complaint other
1.5
6.7
214
1502
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.8
6.7
100
579
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
2.9
6.7
30
105
H02AB07
ATC
prednisone; oral
1.7
6.7
139
883
P03
ICPC
Feeling depressed
1.8
6.6
94
536
J01AA02
ATC
doxycycline; systemic
1.4
6.6
816
7290
A10AA01, ,
ATC
2.8
6.6
32
117
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.3
6.6
48
214
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.5
6.6
206
1440
J01MA12
ATC
levofloxacin; systemic
1.5
6.5
190
1306
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
2.6
6.5
36
141
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
6.5
293
2203
N17
ICPC
Vertigo/dizziness
1.6
6.5
142
913
H53.1
ICD-10 Finland
Subjective visual disturbances
1.9
6.5
77
414
Z49.0
ICD-10 Finland
Preparatory care for dialysis
5.4
6.5
18
34
H3600, E103,
ICD-10 Finland
5.7
6.5
17
30
A10AB05
ATC
insulin aspart; parenteral
1.9
6.4
85
474
CBF10
NOMESCO Finland
Shortening of canthal ligaments and tarsal plate for ectropion
14.4
6.4
10
7
H10.5
ICD-10 Finland
Blepharoconjunctivitis
3.1
6.4
26
86
H40.9
ICD-10 Finland
Glaucoma, unspecified
3.1
6.4
26
86
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
8.2
6.3
13
16
H26.1
ICD-10 Finland
Traumatic cataract
8.2
6.3
13
16
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
8.2
6.3
13
16
CFW99
NOMESCO Finland
Other operation on conjunctiva
11.1
6.3
11
10
NHQ40
NOMESCO Finland
Amputation of toe
3.4
6.3
22
66
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.2
6.3
52
245
H19.2*B30.0
ICD-10 Finland
Epidemic keratoconjunctivitis
+∞
6.3
6
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
6.3
6
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
6.3
6
*
CGA00
NOMESCO Finland
Biopsy of cornea
+∞
6.3
6
*
T85.3
ICD-10 Finland
Mechanical complication of other ocular prosthetic devices, implants and grafts
+∞
6.3
6
*
37108
ICD-8 Finland
Corneal opacity, Alia definita
+∞
6.3
6
*
36300
ICD-8 Finland
Keratitis, Ulcerosa
+∞
6.3
6
*
A10AB04
ATC
insulin lispro; parenteral
2.5
6.2
39
162
H44.5
ICD-10 Finland
Degenerated conditions of globe
26.8
6.2
8
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
7.1
6.2
14
20
A10AC01
ATC
insulin (human); parenteral
1.8
6.2
84
471
F38
ICPC
Eye, Other laboratory test NEC
3.1
6.2
25
82
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.1
6.2
53
253
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.3
6.2
43
188
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
6.1
679
5913
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
6.1
530
4441
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
2.7
6.0
31
117
Z3226
NOMESCO Finland
Physiotherapist
1.5
6.0
184
1278
3AC01, ,
NOMESCO Finland
5.6
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
87
12.65
100.15
1.6
1.3
—
—
—
0
0
62
55
11.87
59.97
1.6
1.2
—
—
—
0
0
216
1181
2.03
17.64
5.2
4.4
234.94
254.15
u/l
1.23
207
1128
595
4488
1.69
16.37
7.5
5.2
35.00
35.53
g/l
1.38
561
4225
284
1742
1.84
16.31
4.1
2.5
12.58
12.93
umol/l
0.37
256
1633
283
1735
1.84
16.28
5.0
3.4
0.81
0.82
mmol/l
0.36
266
1642
305
1961
1.76
14.77
4.9
4.0
203.60
411.06
ng/l
1.84
240
1537
261
1632
1.78
13.79
4.3
2.5
2.26
2.30
g/l
0.62
238
1520
875
7494
1.74
13.43
10.9
8.4
83.36
80.38
u/l
0.64
841
7128
227
1381
1.81
13.09
11.6
5.9
1.09
1.04
mmol/l
1.88
211
1277
658
5279
1.59
12.73
7.8
6.8
12.02
11.59
umol/l
0.22
632
5049
380
2682
1.63
12.62
2.8
2.3
2.90
2.91
mg/l
0.04
326
2302
700
5709
1.60
12.54
13.0
9.7
4.17
4.12
e9/l
0.21
613
4961
572
4464
1.57
12.31
3.1
2.5
78.28
77.26
nmol/l
0.37
514
4023
166
933
1.91
12.25
3.1
2.9
68.86
69.58
e9/l
0.09
120
704
241
1521
1.74
12.17
4.4
2.5
21.92
22.80
%
0.52
221
1430
839
7187
1.65
11.93
5.7
4.3
14.15
12.33
mm/h
2.57
791
6717
38
108
3.61
11.64
1.3
1.1
—
—
—
0
0
633
5105
1.55
11.41
11.7
7.4
1.21
1.21
mmol/l
0.04
551
4402
854
7410
1.63
10.87
4.8
4.3
14.83
14.83
pmol/l
0.00
777
6805
1032
9457
2.06
10.73
25.5
16.4
24.63
25.02
mg/l
0.14
891
7809
561
4448
1.52
10.65
2.4
2.2
96.09
95.39
pmol/l
0.13
297
2366
589
4728
1.51
10.48
21.1
15.2
1.31
1.26
inr
1.19
510
3951
978
8823
1.81
10.44
6.1
5.3
1.98
1.93
mu/l
0.61
901
8150
143
807
1.88
10.36
6.2
3.9
109.00
85.18
ng/l
1.58
129
704
356
2573
1.56
10.27
5.7
4.2
87.10
89.18
%
0.76
349
2535
757
6431
1.54
10.14
6.0
4.8
2007.50
2423.48
e6/l
—
10
99
571
4596
1.49
9.76
10.2
6.8
1.21
1.21
mmol/l
0.10
531
4251
252
1702
1.62
9.62
1.9
1.8
1100.65
1181.70
nmol/l
0.81
196
1275
159
949
1.79
9.60
13.9
7.3
10.59
9.76
mmol/l
0.85
154
911
415
3151
1.50
9.33
2.6
2.2
204.39
245.87
u/l
0.45
395
3008
1043
9673
2.03
9.25
29.7
19.6
139.54
139.61
mmol/l
0.40
1026
9490
256
1752
1.60
9.21
2.3
1.9
—
—
—
0
0
436
3364
1.48
8.97
3.8
3.3
31.00
33.68
u/l
1.12
416
3179
182
1153
1.69
8.87
3.5
2.9
8.84
8.26
umol/l
0.11
161
1026
1042
9685
1.98
8.80
30.5
19.8
3.99
3.98
mmol/l
1.11
1024
9478
92
472
2.03
8.79
2.2
2.0
1.56
1.51
g/l
0.14
82
424
171
1087
1.68
8.20
8.6
3.8
1.76
1.91
mmol/l
0.21
153
933
474
3765
1.45
8.18
5.6
4.0
138.28
113.52
e6/l
0.17
352
2676
691
5922
1.43
7.64
7.2
5.3
6.87
6.71
mmol/l
1.16
659
5637
174
1132
1.63
7.60
8.5
3.8
5.94
5.82
kpa
0.76
169
1103
78
398
2.03
7.58
2.4
2.2
40.10
39.40
u/l
0.11
73
354
405
3160
1.44
7.54
4.2
2.7
61.45
84.69
u/l
0.44
382
2952
60
277
2.23
7.53
1.7
1.7
—
—
—
0
0
159
1017
1.66
7.42
2.5
2.4
0.20
0.21
g/l
0.30
151
959
373
2874
1.44
7.40
4.6
3.3
0.38
0.46
e6/l
0.40
286
2111
974
8961
1.63
7.39
7.5
6.5
39.95
39.42
mmol/mol
0.99
912
8397
304
2253
1.48
7.38
2.1
1.7
1.22
1.25
mg/l
0.08
233
1748
422
3334
1.42
7.27
4.8
3.4
73.91
80.01
e6/l
0.06
336
2548
195
1318
1.58
7.26
2.3
1.8
—
—
—
0
0
252
1804
1.51
7.24
3.8
2.9
0.77
1.12
e6/l
1.97
148
966
1064
10054
2.01
7.13
31.4
21.4
84.95
78.22
umol/l
3.94
1049
9945
128
783
1.72
7.05
1.8
1.7
—
—
—
0
0
615
5207
1.40
7.01
4.8
3.9
0.00
0.00
estimate
0.50
116
1114
624
5297
1.40
7.00
4.8
4.0
0.00
0.29
estimate
0.53
103
1068
1055
9960
1.90
6.79
16.6
12.2
25.94
26.51
u/l
0.44
1029
9701
982
9099
1.61
6.69
22.6
15.9
78.72
80.51
ml/min/173m2
1.57
919
8426
617
5262
1.38
6.54
4.8
4.0
0.02
5.86
estimate
1.33
117
1137
336
2588
1.42
6.53
3.7
2.8
354.57
347.67
umol/l
0.58
299
2276
134
848
1.66
6.51
2.5
3.0
65.97
66.80
g/l
0.57
122
788
268
1981
1.46
6.49
1.8
1.5
2.55
2.50
g/l
0.12
172
1232
183
1255
1.55
6.36
2.3
1.9
—
—
—
0
0
180
1232
1.55
6.31
2.2
2.5
113.04
130.19
ug/g
0.42
150
994
125
786
1.66
6.22
2.9
2.8
63.38
65.89
ml/min/173m2
0.26
55
345
1078
10287
2.06
6.16
37.6
25.1
247.87
247.93
e9/l
0.01
1059
10085
143
934
1.61
6.12
3.7
2.5
40.99
39.99
u/l
0.05
122
788
1078
10290
2.05
6.11
37.4
25.0
91.41
91.15
fl
1.09
1067
10178
12
14
8.65
6.06
1.2
1.1
—
—
—
0
0
1078
10293
2.05
6.05
37.5
25.0
4.40
4.49
e12/l
5.65
1052
10060
1078
10293
2.05
6.05
38.1
25.6
39.75
40.32
%
2.95
1067
10173
1078
10293
2.05
6.05
37.6
25.1
6.88
6.75
e9/l
0.73
1052
10059
67
353
1.95
6.00
2.8
2.7
10.24
10.72
g/l
0.43
60
318
1078
10297
2.04
5.98
37.9
25.2
132.93
135.23
g/l
5.02
1069
10186
40
172
2.37
5.96
1.3
1.3
—
—
—
0
0
28
101
2.82
5.92
1.2
1.2
56.07
50.37
u/l
0.33
28
91
549
4641
1.36
5.91
4.8
3.0
143.53
129.68
ug/l
0.61
505
4313
19
54
3.56
5.90
1.3
1.2
97.11
79.51
u/l
0.49
19
47
979
9121
1.55
5.87
5.7
5.2
6.00
5.96
mmol/l
0.36
889
8364
60
307
2.01
5.84
2.5
1.6
1.15
1.20
g/l
0.46
54
293
389
3121
1.38
5.82
4.0
3.3
1560.06
1340.62
ng/l
0.55
345
2675
43
194
2.26
5.76
1.4
1.3
—
—
—
0
0
43
194
2.26
5.76
1.4
1.3
—
—
—
0
0
126
810
1.63
5.75
4.4
3.1
342.17
203.02
ng/l
1.02
118
740
429
3511
1.36
5.62
4.2
3.6
2.35
2.35
mmol/l
0.26
394
3186
1009
9485
1.60
5.59
6.4
5.8
2.62
2.68
mmol/l
1.19
935
8806
47
224
2.15
5.52
12.2
6.3
754.07
363.70
iu/ml
0.30
14
33
18
52
3.50
5.46
1.3
1.2
26.44
18.05
u/l
0.49
18
44
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
62
331
1.92
5.36
4.2
2.8
0.35
0.35
iu/ml
0.01
31
181
17
48
3.58
5.34
2.0
3.3
596.88
1541.56
u/ml
1.01
17
48
57
297
1.97
5.29
2.5
1.5
0.24
0.24
g/l
0.03
52
284
293
2278
1.39
5.22
1.4
1.3
1.56
1.82
u/ml
0.14
76
649
59
313
1.93
5.21
1.9
1.3
—
—
—
0
0
57
304
1.92
4.97
2.9
2.7
0.00
0.00
g/l
-0.00
50
267
366
2971
1.34
4.92
2.0
1.7
19.46
20.29
nmol/l
0.48
312
2521
222
1662
1.42
4.91
3.9
3.1
1.47
2.35
e6/l
1.65
117
819
41
195
2.14
4.87
2.0
1.4
140.50
156.53
au/ml
0.30
14
59
989
9308
1.50
4.86
5.5
5.0
1.42
1.45
mmol/l
1.46
912
8630
862
7919
1.37
4.84
31.9
20.3
13.76
13.65
%
1.56
846
7833
67
380
1.81
4.83
2.9
2.7
3.06
3.01
g/l
0.15
62
347
993
9356
1.51
4.82
5.6
5.1
4.52
4.60
mmol/l
1.29
925
8727
45
225
2.04
4.71
1.6
1.6
—
—
—
0
0
951
8896
1.44
4.69
4.7
4.3
1.28
1.29
mmol/l
0.24
873
8176
23
86
2.71
4.60
1.4
2.5
1192.35
1044.60
mg
0.12
23
86
140
972
1.50
4.57
6.6
3.3
4.79
4.44
kpa
1.36
135
949
69
402
1.76
4.57
2.8
2.6
3.57
3.66
g/l
0.32
64
370
69
403
1.76
4.53
2.8
2.6
7.75
7.41
g/l
0.65
64
370
69
403
1.76
4.53
2.8
2.6
4.13
4.24
g/l
0.68
64
370
213
1606
1.40
4.50
2.9
2.0
29.46
29.40
s
0.05
208
1562
52
279
1.91
4.48
1.9
1.7
—
—
—
0
0
856
7889
1.35
4.45
32.9
21.2
331.57
332.50
g/l
2.07
850
7847
289
2294
1.35
4.44
4.1
2.7
4.96
5.60
e6/l
0.35
268
2099
57
320
1.82
4.28
1.4
1.5
0.06
23.80
iu/ml
0.50
13
51
56
314
1.82
4.22
2.9
2.7
0.00
0.02
g/l
0.50
50
285
125
863
1.50
4.20
2.5
2.5
5.76
7.37
ug/l
0.96
105
770
723
6535
1.30
4.14
4.4
3.4
57.69
51.10
u/l
0.69
680
6162
138
976
1.47
4.12
2.8
2.1
356.08
377.34
nmol/l
0.74
128
910
50
273
1.87
4.11
1.6
1.6
—
—
—
0
0
8
10
8.05
4.06
14.3
7.3
4.00
7.27
mmol/l
—
8
10
12
26
4.65
4.06
1.1
1.0
—
—
—
0
0
75
466
1.65
3.97
1.1
1.0
—
—
—
0
0
536
4682
1.28
3.96
3.4
2.8
—
—
estimate
—
0
0
54
306
1.80
3.95
3.2
3.8
1.72
2.29
ratio
0.71
30
176
418
3544
1.28
3.91
4.9
3.4
6.89
7.68
mmol/l
3.31
370
3018
308
2511
1.31
3.87
3.1
2.5
—
—
—
0
0
49
272
1.84
3.84
4.8
3.4
2.25
1.87
index
0.23
24
148
256
2038
1.33
3.80
3.3
3.0
2.45
2.45
mmol/l
0.10
232
1847
57
336
1.73
3.67
3.2
4.0
31.56
56.64
mg/l
1.30
47
289
55
321
1.75
3.67
1.5
1.3
—
—
—
0
0
60
359
1.71
3.67
3.0
2.9
1.00
1.23
g/l
0.19
55
315
164
1224
1.40
3.66
8.0
8.3
1.26
1.04
mmol/l
0.28
139
1013
61
367
1.70
3.66
3.7
3.0
—
—
—
0
0
62
376
1.69
3.61
1.4
1.2
1.07
1.42
u/ml
—
6
21
62
379
1.67
3.52
2.3
1.9
—
—
—
0
0
57
341
1.71
3.50
1.4
1.3
—
—
—
0
0
164
1238
1.38
3.42
8.2
8.2
5.14
5.13
kpa
0.05
157
1195
450
3898
1.26
3.41
4.5
3.9
33.58
81.32
ng/l
1.27
331
2821
164
1239
1.38
3.41
8.1
8.2
12.70
12.17
kpa
0.48
157
1199
56
337
1.70
3.37
3.2
4.0
43.21
65.16
mg/l
0.62
46
289
24
108
2.25
3.33
1.6
1.3
21.70
26.56
ng/l
0.54
24
108
55
333
1.69
3.25
1.6
1.6
—
—
—
0
0
40
221
1.84
3.22
1.3
1.2
22.28
54.78
u/ml
—
5
21
93
643
1.49
3.14
2.1
1.7
—
—
—
0
0
73
480
1.56
3.11
3.2
3.6
1.02
1.02
ratio
0.01
67
447
394
3396
1.25
3.04
5.4
4.2
14.46
8.87
mg/mmol
1.27
255
2156
54
332
1.66
3.03
4.9
2.3
95.87
92.39
%
0.58
54
321
27
133
2.06
3.03
1.5
1.7
—
—
—
0
0
82
559
1.50
2.98
4.1
3.6
4.52
4.61
pmol/l
0.20
73
498
94
659
1.47
2.98
2.5
2.5
17.50
17.58
au/ml
—
8
64
56
352
1.62
2.90
2.0
1.8
—
—
—
0
0
40
231
1.76
2.83
1.2
1.5
—
—
—
0
0
62
404
1.57
2.78
2.5
1.7
11.52
5.69
iu/ml
0.63
11
92
34
188
1.83
2.77
1.7
1.8
—
—
—
0
0
18
78
2.33
2.75
1.8
1.1
103.89
105.22
pmol/l
0.03
18
78
89
632
1.44
2.66
8.6
10.6
24.32
24.42
mmol/l
0.12
84
623
36
206
1.77
2.64
1.7
1.2
212.75
258.77
u/ml
0.61
28
119
135
1034
1.35
2.59
3.5
3.4
—
—
—
0
0
45
278
1.64
2.52
1.4
1.2
3.94
2.35
u/ml
—
5
26
45
278
1.64
2.52
1.4
1.2
3.16
8.11
u/ml
—
9
39
15
63
2.40
2.47
7.9
2.0
—
—
—
0
0
200
1635
1.27
2.39
1.5
1.5
—
—
—
0
0
47
300
1.59
2.34
1.5
1.5
236.54
278.23
ug/g
0.61
25
189
61
414
1.50
2.32
2.3
2.0
—
—
—
0
0
10
34
2.96
2.28
3.9
3.0
0.62
0.60
mmol/l
—
10
34
30
171
1.77
2.26
1.5
1.3
—
328.33
—
0
12
15
66
2.29
2.25
1.4
1.4
—
—
—
0
0
29
164
1.79
2.24
1.7
1.2
2.25
5.38
u/ml
1.06
16
53
65
451
1.47
2.23
2.0
1.9
2.02
2.28
ug/l
0.10
56
404
19
93
2.06
2.22
1.4
1.2
—
—
—
0
0
23
121
1.92
2.22
1.4
1.4
1383.67
1746.82
e6/l
0.19
15
82
630
5813
1.19
2.20
3.1
3.0
—
—
—
0
0
20
101
2.00
2.16
3.3
4.2
—
—
—
0
0
7
19
3.70
2.15
1.3
1.1
112.57
89.68
%
—
7
19
14
61
2.31
2.15
2.9
1.7
—
—
—
0
0
247
2099
1.23
2.09
1.9
1.7
137799483.99
25693274.39
pmol/l
0.92
209
1732
16
75
2.15
2.09
1.3
1.1
—
—
—
0
0
38
238
1.62
2.07
2.2
2.1
131.10
129.24
g/l
0.15
30
188
70
501
1.42
2.06
2.4
2.1
—
—
—
0
0
41
263
1.58
2.03
1.7
2.0
2.52
27.12
iu/l
0.55
13
102
22
120
1.85
1.93
1.6
1.4
—
—
—
0
0
16
78
2.07
1.91
1.4
1.1
—
—
—
0
0
16
78
2.07
1.91
1.4
1.1
—
—
—
0
0
17
85
2.02
1.91
1.4
1.1
—
—
—
0
0
31
190
1.65
1.85
1.2
1.5
—
—
—
0
0
20
108
1.87
1.82
1.4
1.4
12323.00
42389.46
e6/l
—
10
59
40
264
1.53
1.78
1.8
1.6
33191.13
15108.72
e6/l
0.65
31
185
269
2341
1.20
1.78
4.7
4.1
1.02
1.02
kg/l
2.23
196
1552
14
67
2.10
1.76
1.1
1.6
13.21
13.06
umol/l
0.03
14
62
37
242
1.55
1.72
1.5
1.2
—
—
—
0
0
10
40
2.51
1.66
1.1
1.3
199.00
185.32
mmol/24h
—
10
40
93
724
1.31
1.66
5.5
3.6
5.20
5.12
kpa
0.41
85
706
15
76
1.99
1.64
1.4
1.1
—
—
—
0
0
10
41
2.45
1.64
1.0
1.1
1080.75
243.58
iu/ml
—
10
41
19
105
1.82
1.63
1.6
1.5
—
—
—
0
0
329
2933
1.17
1.63
4.7
4.1
0.00
0.01
estimate
1.15
105
1024
13
63
2.08
1.60
5.8
4.5
1.69
0.94
index
0.46
13
63
8
32
2.51
1.60
1.0
1.7
—
—
—
0
0
6
20
3.01
1.58
1.0
1.2
—
—
—
0
0
11
50
2.21
1.57
1.5
1.3
—
—
—
0
0
11
50
2.21
1.57
1.5
1.3
—
—
—
0
0
83
642
1.32
1.57
1.6
1.3
363.34
214.36
u/ml
0.64
77
595
26
160
1.64
1.56
1.8
1.2
4.33
3.91
u/ml
0.13
15
70
210
1810
1.20
1.54
1.3
1.3
31.84
30.94
iu/ml
0.04
69
541
5
15
3.34
1.52
1.8
1.1
—
—
—
0
0
7
27
2.60
1.51
1.3
1.3
—
—
—
0
0
80
619
1.31
1.51
5.3
3.6
1.49
1.80
mmol/l
0.22
60
465
22
131
1.69
1.50
1.7
1.5
—
—
—
0
0
22
131
1.69
1.50
1.7
1.5
—
—
—
0
0
23
139
1.67
1.49
1.6
1.6
—
—
—
0
0
17
94
1.82
1.47
1.1
1.7
—
—
—
0
0
22
132
1.68
1.46
1.7
1.5
—
—
—
0
0
38
261
1.47
1.45
1.7
1.6
—
—
—
0
0
26
164
1.60
1.44
1.2
1.1
142.58
115.59
iu/ml
—
6
32
13
66
1.98
1.43
1.5
1.4
—
—
—
0
0
365
3310
1.15
1.43
5.6
5.4
2.01
2.61
ug/l
1.15
334
3002
40
280
1.44
1.39
1.6
1.4
—
—
—
0
0
19
111
1.72
1.39
2.1
1.8
—
—
—
0
0
18
104
1.74
1.37
2.1
1.9
—
—
—
0
0
32
215
1.50
1.37
8.8
2.0
0.98
0.92
nmol/l
0.16
27
178
54
401
1.36
1.36
6.6
4.1
25.14
24.86
mmol/l
0.17
47
377
9
42
2.15
1.34
1.1
1.0
1133.67
1348.43
miu/ml
—
9
42
11
54
2.05
1.33
1.2
1.6
1.02
1.14
nmol/l
0.17
11
39
34
233
1.47
1.33
3.4
1.5
56.30
34.51
e6/l
0.23
27
170
9
43
2.10
1.30
1.2
1.7
8.81
8.00
mmol/l
—
9
43
22
137
1.62
1.30
1.7
1.5
—
—
—
0
0
22
137
1.62
1.30
1.7
1.4
—
—
—
0
0
22
137
1.62
1.30
1.7
1.4
—
—
—
0
0
295
2657
1.15
1.26
4.5
4.5
20.98
21.32
%
0.16
141
1256
19
115
1.66
1.25
3.3
2.5
20.17
26.16
mg/l
—
6
47
39
280
1.41
1.22
1.2
1.3
260.46
250.31
miu/ml
0.04
11
133
70
552
1.29
1.20
1.7
1.4
—
—
—
0
0
6
26
2.31
1.19
1.3
1.2
—
—
—
0
0
34
240
1.43
1.17
2.9
2.3
249.58
85.91
ug/min
0.95
24
147
55
421
1.32
1.17
1.7
1.4
24.99
25.67
iu/l
0.06
47
350
10
50
2.01
1.16
2.1
1.8
—
—
—
0
0
10
50
2.01
1.16
2.1
1.8
—
—
—
0
0
10
50
2.01
1.16
2.1
1.8
—
—
—
0
0
10
50
2.01
1.16
2.1
1.8
—
—
—
0
0
434
4034
1.12
1.12
2.1
2.0
1.33
1.35
mmol/l
0.27
376
3410
8
40
2.01
1.12
1.9
2.1
—
1968.44
—
0
7
428
3977
1.12
1.11
4.8
3.9
0.05
0.04
estimate
0.17
93
934
105
878
1.22
1.10
3.3
2.4
0.35
0.50
e6/l
0.50
100
840
29
202
1.45
1.08
1.2
1.5
—
—
—
0
0
11
59
1.87
1.07
2.5
1.7
119.00
91.43
ng/l
0.26
11
59
7
33
2.13
1.05
1.6
1.2
12.46
9.43
ug/l
—
7
33
33
237
1.40
1.05
3.3
1.4
3.91
3.77
mmol/l
0.22
33
225
9
46
1.96
1.03
2.6
1.6
—
—
—
0
0
18
114
1.59
1.03
3.1
7.4
7.58
7.26
mmol/l
0.12
13
96
9
47
1.92
1.02
1.2
1.1
—
—
—
0
0
16
99
1.63
1.00
1.2
1.2
—
—
—
0
0
24
164
1.47
0.99
1.2
1.5
—
—
—
0
0
37
276
1.35
0.96
1.3
1.2
—
—
—
0
0
11
62
1.78
0.94
1.1
1.2
—
—
—
0
0
38
286
1.34
0.94
1.9
1.5
9.02
8.64
u/l
0.06
30
225
80
665
1.22
0.91
1.2
1.2
131.00
137.66
u/ml
0.06
27
256
6
28
2.15
0.91
1.2
1.0
—
—
—
0
0
12
194
0.61
0.89
1.6
1.5
0.96
1.16
ratio
—
7
113
12
194
0.61
0.89
1.6
1.5
1.09
1.25
ratio
—
7
113
12
194
0.61
0.89
1.6
1.5
—
—
—
0
0
12
194
0.61
0.89
1.6
1.5
1.02
0.94
ratio
—
7
113
13
79
1.65
0.88
3.9
2.4
18.68
20.65
nmol/l
0.37
13
74
10
56
1.79
0.88
1.3
1.2
—
—
—
0
0
188
1685
1.14
0.88
1.3
1.3
19.09
11.45
u/ml
0.40
55
618
36
274
1.32
0.84
1.3
1.2
—
—
—
0
0
11
65
1.70
0.82
1.5
1.5
—
—
—
0
0
42
329
1.29
0.81
2.1
1.9
39.05
39.19
nmol/l
0.01
42
316
43
338
1.28
0.81
1.7
1.6
5.77
12.84
u/ml
—
8
73
22
305
0.72
0.80
1.1
1.1
0.69
0.70
ratio
—
5
38
6
33
1.82
0.79
1.5
1.3
—
—
—
0
0
19
132
1.45
0.76
1.3
1.3
0.63
14.14
nmol/l
0.50
19
126
0
28
0.00
0.76
0.0
1.1
—
35.48
—
0
28
13
83
1.57
0.75
1.1
1.6
—
—
—
0
0
5
24
2.09
0.74
1.4
1.1
—
—
—
0
0
5
24
2.09
0.74
1.4
1.2
—
—
—
0
0
5
25
2.00
0.72
1.2
1.1
—
—
—
0
0
5
25
2.00
0.72
1.2
1.2
—
—
—
0
0
25
333
0.75
0.72
1.2
1.1
1.49
1.53
g/l
0.37
25
333
16
230
0.69
0.72
1.4
1.5
—
—
—
0
0
5
26
1.93
0.70
1.2
1.2
—
—
—
0
0
14
93
1.51
0.69
1.9
1.6
—
—
—
0
0
14
93
1.51
0.69
1.9
1.6
—
—
—
0
0
14
93
1.51
0.69
1.9
1.6
—
—
—
0
0
36
284
1.28
0.68
1.3
1.3
—
—
—
0
0
11
69
1.60
0.68
2.4
2.9
13.03
8.46
mmol/l
0.63
11
69
9
59
1.53
0.68
2.1
2.5
—
—
—
0
0
27
349
0.77
0.65
1.4
1.2
0.93
0.91
g/l
0.14
27
349
21
154
1.37
0.65
1.1
1.1
—
—
—
0
0
102
899
1.15
0.64
3.1
2.3
12.55
13.22
nmol/l
0.41
93
825
35
278
1.27
0.64
5.8
3.0
1.71
1.57
mmol/l
0.29
35
272
54
453
1.20
0.62
2.4
1.7
0.27
0.35
mg/l
0.44
25
221
13
88
1.48
0.60
1.0
1.1
—
—
—
0
0
29
227
1.28
0.60
5.6
3.2
7.65
7.61
mmol/l
0.02
29
222
17
122
1.40
0.60
2.1
2.0
—
2022.86
—
0
7
0
21
0.00
0.60
0.0
1.6
—
8.42
—
0
13
133
1200
1.12
0.60
2.1
1.8
1.69
1.50
%
1.16
117
1043
18
242
0.74
0.58
1.4
1.4
—
—
—
0
0
18
132
1.37
0.57
1.1
1.1
0.90
1.68
eliau/ml
—
10
58
8
55
1.46
0.56
1.5
7.2
—
81.08
—
0
13
6
38
1.58
0.54
2.5
2.0
—
—
—
0
0
6
38
1.58
0.54
2.5
1.9
—
—
—
0
0
6
38
1.58
0.54
2.5
1.9
—
—
—
0
0
9
60
1.50
0.54
1.6
1.5
169.78
164.95
pmol/l
—
9
60
9
60
1.50
0.54
1.4
1.1
—
—
—
0
0
6
39
1.54
0.53
1.7
1.8
39.40
39.89
g/l
—
6
39
9
63
1.43
0.52
1.0
1.1
—
—
—
0
0
53
453
1.18
0.52
1.4
1.3
—
—
—
0
0
6
40
1.50
0.51
1.3
1.3
—
—
—
0
0
31
251
1.24
0.51
1.1
1.1
9.28
4.62
eliau/ml
—
5
31
91
812
1.13
0.51
6.4
3.9
1.22
1.23
mmol/l
0.33
77
700
9
65
1.39
0.50
1.1
1.1
220.44
244.19
mg/l
—
9
57
6
41
1.47
0.50
1.3
1.3
—
—
—
0
0
28
229
1.23
0.44
1.1
1.5
—
—
—
0
0
13
95
1.37
0.44
1.5
1.1
—
81.83
—
0
6
9
130
0.69
0.43
1.1
1.1
—
—
—
0
0
5
32
1.56
0.42
1.4
1.3
—
—
—
0
0
8
57
1.41
0.42
3.4
1.7
—
—
—
0
0
8
57
1.41
0.42
3.4
1.7
—
—
—
0
0
10
70
1.43
0.41
1.4
1.3
—
—
—
0
0
210
1982
1.07
0.40
3.3
3.2
0.70
0.75
ug/l
0.60
145
1246
85
770
1.11
0.39
1.6
1.4
—
—
—
0
0
5
35
1.43
0.39
1.6
1.2
—
—
—
0
0
10
71
1.41
0.39
1.4
1.3
—
—
—
0
0
20
160
1.25
0.38
1.2
1.1
—
1.35
—
0
9
32
271
1.19
0.37
2.8
2.3
5906.04
5795.52
u/l
0.01
13
117
31
268
1.16
0.30
1.2
1.2
—
—
—
0
0
17
139
1.23
0.29
1.4
1.8
—
—
—
0
0
8
62
1.29
0.28
1.0
1.5
—
—
—
0
0
9
118
0.76
0.27
1.4
1.6
61.65
55.32
ug/l
—
9
118
16
193
0.83
0.26
1.0
1.5
146.27
184.38
pmol/l
0.20
16
188
8
67
1.20
0.26
1.0
1.5
—
—
—
0
0
138
1308
1.06
0.25
1.4
1.5
—
—
—
0
0
126
1191
1.07
0.25
5.0
4.9
33.43
32.13
%
0.71
79
781
294
2849
1.04
0.24
4.3
3.3
0.01
0.04
estimate
0.44
87
883
27
238
1.14
0.22
3.2
3.5
0.82
0.79
nmol/l
0.14
22
195
91
857
1.07
0.21
2.4
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
16
188
0.85
0.21
1.3
1.1
1.14
2.53
u/ml
0.85
11
107
20
173
1.16
0.21
1.5
1.6
—
—
—
0
0
11
89
1.24
0.21
1.1
1.0
293.27
280.43
mg/l
0.19
11
79
12
99
1.21
0.19
1.2
1.3
—
—
—
0
0
6
52
1.15
0.19
1.3
1.7
1.67
2.50
u/field
—
6
36
25
279
0.89
0.18
1.4
1.5
—
—
—
0
0
7
60
1.17
0.18
1.0
1.5
—
—
—
0
0
7
60
1.17
0.18
1.3
1.9
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
60
1.17
0.18
1.4
1.2
—
—
—
0
0
16
138
1.16
0.17
1.1
1.0
—
—
—
0
0
6
78
0.77
0.15
1.3
1.1
—
16.07
—
0
33
9
80
1.13
0.15
1.2
1.4
—
—
—
0
0
12
105
1.14
0.11
1.3
1.4
—
—
—
0
0
13
146
0.89
0.10
1.5
1.7
—
—
—
0
0
38
359
1.06
0.10
1.6
1.9
4.36
3.91
mg/l
0.14
31
264
5
48
1.04
0.09
5.6
2.8
183.20
198.56
u/l
—
5
48
6
57
1.05
0.08
1.7
1.1
—
—
—
0
0
5
60
0.83
0.08
1.6
1.8
—
—
—
0
0
116
1132
1.03
0.08
9.3
7.5
—
—
—
0
0
109
1066
1.02
0.07
4.2
4.4
126.88
25.17
ug/l
0.46
93
888
9
105
0.86
0.06
2.7
2.8
—
—
—
0
0
74
726
1.02
0.04
2.2
1.8
3.46
3.47
mmol/l
0.02
53
537
40
408
0.98
0.01
3.0
3.6
30.49
3356.42
u/ml
0.79
33
358
11
104
1.06
0.01
2.0
2.2
17.14
8.56
umol/l
—
5
77
95
945
1.01
0.00
2.6
2.1
—
—
—
0
0
11
115
0.96
0.00
1.3
1.1
0.30
0.21
u/ml
—
5
44
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
0.00
5.2
4.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.71
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.7
1.6
112.17
81.43
umol/l
—
6
68
8
87
0.92
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
100
1000
1.00
-0.00
2.4
2.0
3.40
3.50
ratio
0.35
79
812
0
9
0.00
-0.00
0.0
3.0
—
4.03
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
12.71
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALSCAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALSCAR | 1.124 [0.99, 1.28] | 0.082 |
| Birth year | 0.992 [0.98, 1.0] | 0.07 |
During the follow-up period (1.1.1998 — 31.12.2019), 740 out of 2917 females with H7_CORNEALSCAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALSCAR | 1.186 [1.02, 1.38] | 0.028 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 559 out of 2918 males with H7_CORNEALSCAR died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALSCAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.264% |
| 5 | 0.564% | 1.544% |
| 10 | 1.441% | 3.449% |
| 15 | 2.847% | 6.67% |
| 20 | 5.252% | 10.94% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALSCAR – Corneal scars and opacities
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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