corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
157 |
4. Check minimum number of eventsNone |
157 |
5. Include endpointsNone |
157 |
6. Filter based on genotype QC (FinnGen only) |
145 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Abnormitates membranarum cornealium
Similar endpoints
↥List of similar endpoints to
Changes in corneal membranes
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Keratitis
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 414 | 262 | 151 |
| Only index persons | 402 | 255 | 147 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.95 | 63.82 | 58.75 |
| Only index persons | 61.37 | 62.88 | 58.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 145 | 102 | 43 |
| Unadjusted period prevalence (%) | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | 65.38 | 65.77 | 64.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 148
- Matched controls
- 1480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
213.9
148
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
12.9
35.8
128
492
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
407.7
33.3
32
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
270.1
23.3
23
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
+∞
22.5
21
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.5
19.6
38
75
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.4
18.6
47
118
H16.0
ICD-10 Finland
Corneal ulcer
21.7
18.6
27
15
H18.4
ICD-10 Finland
Corneal degeneration
+∞
18.1
17
*
H16.9
ICD-10 Finland
Keratitis, unspecified
165.7
14.7
15
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
5.9
14.0
28
56
H26.4
ICD-10 Finland
After-cataract
5.2
13.4
32
75
H04.10
ICD-10 Finland
Dry eye syndrome
4.6
13.1
37
100
CG2S4
NOMESCO Finland
Photography of cornea
+∞
12.7
12
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
10.5
10
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
10.5
10
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.1
10.0
31
89
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
9.5
9
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.0
9.1
58
262
ZXA10
NOMESCO Finland
Bilateral
3.3
8.9
42
159
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.4
8.5
23
59
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
8.4
8
*
CGE10
NOMESCO Finland
Keratectomy
+∞
8.4
8
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.7
7.9
67
348
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.3
7.4
33
120
S01EA05
ATC
brimonidine; ophthalmic
16.8
7.3
11
7
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
7.3
7
*
H18.6
ICD-10 Finland
Keratoconus
+∞
7.3
7
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.7
7.0
17
40
S01AD03
ATC
aciclovir; ophthalmic
8.8
6.5
13
16
CFD10
NOMESCO Finland
Repair of conjunctiva
72.9
6.5
7
*
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
+∞
6.3
6
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
6.3
6
*
H18.8
ICD-10 Finland
Other specified disorders of cornea
+∞
6.3
6
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
+∞
6.3
6
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.4
6.0
60
328
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
10
8
13.29
6.18
1.4
1.4
—
—
—
0
0
11
11
10.69
6.14
1.8
1.2
—
—
—
0
0
91
625
2.18
4.99
3.4
3.0
91.93
109.03
ug/l
0.56
85
584
100
740
2.08
4.18
10.7
11.2
4.01
4.03
e9/l
0.03
88
652
121
978
2.30
3.82
5.4
4.4
11.38
11.74
mm/h
0.15
113
907
85
623
1.86
3.34
2.7
2.4
85.50
77.51
nmol/l
1.48
77
566
67
467
1.79
3.01
3.4
3.1
—
—
—
0
0
5
5
10.28
3.00
4.0
1.4
381.40
1328.80
u/ml
—
5
5
39
230
1.94
2.95
3.1
2.8
1.05
1.08
e6/l
0.04
21
115
50
321
1.84
2.93
2.5
2.1
2.78
2.78
mg/l
0.01
42
275
139
1252
2.81
2.87
17.8
15.0
78.29
81.11
ml/min/173m2
0.91
132
1158
10
30
3.50
2.66
2.6
2.4
12.85
13.42
mg/l
—
10
30
120
1018
1.94
2.59
8.4
7.9
70.32
77.15
u/l
2.24
114
952
120
1022
1.92
2.50
5.3
4.6
15.04
14.74
pmol/l
0.67
112
934
91
725
1.66
2.31
3.2
4.0
0.00
0.00
estimate
-0.00
12
141
65
477
1.65
2.27
3.5
3.6
2.37
2.36
mmol/l
0.54
60
436
89
711
1.63
2.19
3.2
3.9
0.00
0.01
estimate
0.50
12
144
33
206
1.77
2.06
3.2
2.9
0.36
2.93
e6/l
2.37
15
92
6
15
4.12
2.06
1.5
1.2
—
—
—
0
0
6
15
4.12
2.06
1.5
1.5
—
—
—
0
0
6
15
4.12
2.06
1.5
1.5
—
—
—
0
0
89
719
1.60
2.02
3.2
3.9
0.00
0.00
estimate
-0.00
13
150
53
380
1.61
1.98
3.4
3.1
0.44
0.45
e6/l
0.00
38
271
5
11
4.66
1.95
2.6
2.5
12.80
13.15
%
—
5
11
12
53
2.38
1.86
2.1
2.5
47.83
38.70
u/l
0.86
12
48
140
1302
2.39
1.85
20.2
17.6
3.96
3.96
mmol/l
0.02
140
1277
140
1302
2.39
1.85
20.0
17.4
139.70
139.82
mmol/l
0.29
140
1279
8
29
2.86
1.82
1.6
1.2
—
—
—
0
0
26
157
1.80
1.81
2.3
2.5
5.60
4.67
umol/l
0.35
21
133
19
104
1.95
1.77
2.3
2.5
57.71
62.46
ml/min/173m2
—
7
48
35
233
1.66
1.73
4.5
3.7
198.37
266.98
ng/l
0.15
27
178
73
578
1.52
1.72
2.2
2.1
100.03
97.56
pmol/l
0.15
29
283
137
1269
2.07
1.53
19.0
15.1
26.15
21.94
mg/l
0.62
111
1026
80
664
1.45
1.40
6.1
6.9
1.21
1.22
mmol/l
0.28
72
583
76
625
1.44
1.39
2.2
2.6
—
—
estimate
—
0
0
9
43
2.16
1.33
1.3
2.6
0.00
0.00
g/l
—
9
43
5
18
2.84
1.29
1.4
1.1
—
—
—
0
0
132
1222
1.74
1.28
4.2
4.2
1.17
1.27
mmol/l
1.32
126
1111
43
324
1.46
1.23
1.4
1.3
0.96
1.47
u/ml
—
9
89
73
608
1.40
1.19
5.3
6.0
1.21
1.22
mmol/l
0.15
68
570
130
1204
1.66
1.19
6.7
5.7
2.00
1.85
mu/l
0.66
123
1099
22
146
1.60
1.11
4.4
6.9
2.11
1.24
mmol/l
0.61
16
124
7
32
2.25
1.09
1.3
1.6
—
—
—
0
0
119
1087
1.48
1.09
24.9
20.1
330.39
331.35
g/l
0.61
119
1087
7
33
2.18
1.07
1.4
1.3
—
—
—
0
0
131
1223
1.62
1.06
5.8
6.3
38.31
39.05
mmol/mol
0.73
126
1144
39
298
1.42
1.03
1.8
1.7
0.69
1.13
mg/l
1.02
31
240
14
84
1.74
1.02
1.6
1.3
177.19
305.44
u/ml
0.29
14
78
133
1250
1.63
0.99
4.8
5.0
5.75
5.90
mmol/l
1.43
126
1142
5
23
2.21
0.99
2.8
1.8
—
—
—
0
0
17
109
1.63
0.98
1.5
3.3
69.11
67.24
g/l
0.81
17
104
48
384
1.37
0.97
1.8
1.7
24.86
21.76
nmol/l
0.61
42
326
21
144
1.53
0.93
1.8
1.8
—
—
—
0
0
25
179
1.48
0.92
3.2
6.3
103.24
103.75
mmol/l
0.16
25
179
8
43
1.91
0.89
3.8
1.3
0.25
0.24
g/l
—
8
43
13
80
1.69
0.88
3.5
8.4
0.43
0.63
%
1.80
13
80
13
81
1.66
0.84
3.5
8.4
1.65
1.26
%
0.68
13
81
21
148
1.49
0.83
1.8
1.8
—
—
—
0
0
8
47
1.74
0.82
2.5
2.8
—
—
—
0
0
0
24
0.00
0.80
0.0
1.1
—
—
—
0
0
14
92
1.58
0.75
1.1
1.2
39.52
173.75
u/ml
—
5
37
12
80
1.54
0.62
6.9
6.9
25.68
24.56
mmol/l
0.71
12
80
19
141
1.40
0.60
2.5
2.0
3.06
3.28
ratio
0.42
19
117
0
22
0.00
0.60
0.0
1.3
—
1.38
—
0
8
0
23
0.00
0.59
0.0
1.2
—
5.00
—
0
8
37
307
1.27
0.57
3.3
4.2
1.02
1.02
kg/l
0.20
24
212
6
37
1.65
0.56
2.5
1.7
—
—
—
0
0
25
197
1.32
0.56
2.0
1.9
—
—
—
0
0
6
38
1.60
0.55
1.7
1.3
—
—
—
0
0
86
787
1.22
0.54
3.4
3.0
—
—
—
0
0
12
164
0.71
0.48
4.5
4.7
34.43
32.61
%
—
7
95
9
127
0.69
0.45
2.2
2.0
—
—
—
0
0
62
558
1.19
0.44
3.5
3.8
0.40
0.03
estimate
—
10
117
5
31
1.63
0.43
2.4
1.6
—
—
—
0
0
8
56
1.45
0.43
1.4
1.2
—
—
—
0
0
14
105
1.37
0.43
1.5
1.4
—
—
—
0
0
5
32
1.58
0.42
1.4
1.0
3.20
3.25
e6/l
—
5
24
5
33
1.53
0.41
1.4
1.2
102.80
206.76
e6/l
—
5
25
0
15
0.00
0.41
0.0
1.9
—
17.86
—
0
7
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
8
111
0.70
0.39
2.3
1.9
—
—
—
0
0
29
246
1.22
0.38
1.5
1.7
499.41
447.62
pmol/l
0.44
22
208
13
99
1.34
0.37
2.4
1.9
3.41
3.49
mmol/l
0.11
13
72
54
494
1.15
0.30
4.0
4.0
18.98
38.06
ng/l
1.16
37
341
27
234
1.19
0.29
1.4
1.4
—
—
—
0
0
29
254
1.18
0.28
1.3
1.3
1.03
10.54
u/ml
—
9
92
48
441
1.13
0.25
4.1
3.6
10.73
9.27
mg/mmol
0.09
28
259
5
37
1.36
0.24
2.8
1.7
—
—
—
0
0
12
97
1.26
0.23
1.6
1.7
—
—
—
0
0
15
125
1.22
0.23
2.2
2.1
0.24
0.23
g/l
0.22
15
120
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.5
—
1.25
—
0
12
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
42
387
1.12
0.20
3.7
4.1
0.00
0.01
estimate
0.50
11
135
6
48
1.26
0.20
1.2
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
1.63
—
0
8
16
137
1.19
0.19
7.6
7.8
—
—
—
0
0
6
51
1.18
0.19
1.7
1.4
—
—
—
0
0
7
60
1.17
0.18
1.6
2.2
—
—
—
0
0
8
68
1.19
0.17
3.3
3.2
25.00
24.49
mmol/l
—
8
68
12
102
1.19
0.15
1.9
2.8
3.82
4.22
kpa
0.47
12
102
14
121
1.17
0.15
2.9
3.6
5.86
5.80
kpa
0.08
14
121
9
81
1.12
0.15
1.0
1.0
—
—
—
0
0
24
220
1.11
0.12
3.2
2.8
0.79
0.81
mmol/l
0.44
24
210
91
933
0.94
0.11
2.9
3.2
38.82
45.82
u/l
0.67
84
885
5
48
1.04
0.09
1.6
1.5
—
—
—
0
0
33
313
1.07
0.08
1.7
2.1
—
—
—
0
0
6
58
1.04
0.08
1.2
1.1
1.52
1.59
g/l
—
6
58
40
418
0.94
0.08
3.4
3.2
0.20
0.02
estimate
—
10
118
5
61
0.81
0.08
2.4
3.4
23.56
24.99
mmol/l
—
5
61
23
215
1.08
0.08
3.8
4.3
17.85
21.70
%
1.01
13
91
8
74
1.09
0.07
1.1
1.5
—
—
—
0
0
24
227
1.07
0.06
1.3
1.5
—
—
—
0
0
12
127
0.94
0.01
3.8
3.5
—
—
—
0
0
58
588
0.98
0.01
1.8
1.9
1.37
1.36
mmol/l
0.01
52
495
28
277
1.01
0.00
1.5
1.4
12.46
25.21
iu/ml
—
8
99
27
275
0.98
0.00
4.8
4.9
1.34
1.70
ug/l
0.91
27
248
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.7
—
9.94
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
14.56
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.8
—
203.20
—
0
5
0
5
0.00
-0.00
0.0
2.2
—
1.20
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
-0.00
0.0
1.0
—
124.00
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
56.43
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.44
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
1552.75
—
0
8
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
138.60
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
21.40
—
0
7
0
9
0.00
-0.00
0.0
4.7
—
4.69
—
0
9
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.1
0.75
0.87
g/l
—
6
59
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
44.58
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
62
0.97
-0.00
3.0
3.7
49.32
45.64
%
—
6
62
0
5
0.00
-0.00
0.0
1.0
—
113.60
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALMEMBRANE and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H7_CORNEALMEMBRANE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H7_CORNEALMEMBRANE – Changes in corneal membranes
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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