No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
699 |
4. Check minimum number of eventsNone |
699 |
5. Include endpointsNone |
699 |
6. Filter based on genotype QC (FinnGen only) |
641 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Degeneratio corneae
Similar endpoints
↥List of similar endpoints to
Corneal degeneration
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3016 | 1902 | 1102 |
| Only index persons | 2762 | 1757 | 1005 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.03 |
| Only index persons | 0.06 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 65.63 | 67.79 | 62.16 |
| Only index persons | 64.93 | 66.76 | 61.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 641 | 430 | 211 |
| Unadjusted period prevalence (%) | 0.13 | 0.15 | 0.10 |
| Median age at first event (years) | 66.62 | 65.32 | 69.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 662
- Matched controls
- 6620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.4
ICD-10 Finland
Corneal degeneration
+∞
307.7
643
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
1296.1
202.2
187
*
H16.0
ICD-10 Finland
Corneal ulcer
28.2
155.9
109
46
CG2T4
NOMESCO Finland
Topography assessment of cornea
230.5
129.8
130
7
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.6
120.5
213
387
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
8.0
117.6
537
2318
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
229.5
97.3
98
5
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.7
95.3
237
587
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.6
93.9
241
613
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.8
78.3
176
392
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
70.1
66
*
WX140
NOMESCO Finland
Parabulbar anesthesy
7.6
66.9
103
156
H18.8
ICD-10 Finland
Other specified disorders of cornea
692.8
65.0
63
*
CG2S4
NOMESCO Finland
Photography of cornea
182.9
64.2
66
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.8
52.7
140
352
ZXA10
NOMESCO Finland
Bilateral
3.6
48.8
220
806
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.2
48.5
345
1666
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
94.0
47.6
52
6
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
108.0
46.5
50
5
CGE10
NOMESCO Finland
Keratectomy
+∞
46.4
44
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
46.4
44
*
H16.9
ICD-10 Finland
Keratitis, unspecified
90.1
45.5
50
6
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.1
44.5
343
1711
H04.10
ICD-10 Finland
Dry eye syndrome
3.9
43.0
154
480
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
41.1
39
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.0
40.4
301
1454
TCG10
NOMESCO Finland
Removal of sutures from cornea
149.2
40.2
42
*
H26.4
ICD-10 Finland
After-cataract
3.8
39.9
142
439
S01ED01
ATC
timolol; ophthalmic
7.4
39.2
59
86
Z3229
NOMESCO Finland
Other healthcare associate professional
4.1
36.0
110
304
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.6
35.0
91
222
H18.6
ICD-10 Finland
Keratoconus
+∞
34.7
33
*
WX002
NOMESCO Finland
Sedation and analgesia
2.9
32.6
204
880
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
4.2
32.5
96
258
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.9
31.1
191
812
CGE16
NOMESCO Finland
Destruction of lesion of cornea
+∞
29.4
28
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
29.4
28
*
S01EA05
ATC
brimonidine; ophthalmic
7.8
27.4
39
53
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
10.8
26.4
29
28
S01ED51
ATC
timolol, combinations; ophthalmic
3.7
26.0
92
279
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
25.2
24
*
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
+∞
25.2
24
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
24.1
23
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
24.1
23
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
24.1
23
*
ZXA05
NOMESCO Finland
Left side
2.4
23.5
222
1145
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
56.2
23.2
27
5
S01EC01
ATC
acetazolamide; systemic
7.7
23.1
33
45
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
23.1
22
*
Z3231
NOMESCO Finland
Registered nurse
2.4
22.9
229
1209
S01BA01
ATC
dexamethasone; ophthalmic
5.4
22.7
46
90
S01BA07
ATC
fluorometholone; ophthalmic
9.1
22.6
28
32
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.3
22.4
96
328
S01BA04
ATC
prednisolone; ophthalmic
7.9
22.2
31
41
S01BC03
ATC
diclofenac; ophthalmic
7.6
22.2
32
44
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
22.0
21
*
CD2S4
NOMESCO Finland
Photography of eye
26.1
21.9
30
12
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
20.9
20
*
XCK00
NOMESCO Finland
Perimetry
3.7
20.8
69
200
S01GX01
ATC
cromoglicic acid; ophthalmic
2.3
18.5
168
839
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
17.5
17.5
27
16
H52.2
ICD-10 Finland
Astigmatism
6.1
17.1
30
51
H18.2
ICD-10 Finland
Other corneal oedema
+∞
16.7
16
*
3714A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal degenerations
+∞
16.7
16
*
H18.7
ICD-10 Finland
Other corneal deformities
+∞
16.7
16
*
S01EE04
ATC
travoprost; ophthalmic
6.2
15.7
27
45
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
163.7
15.5
16
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
24.0
15.2
21
9
ZXA00
NOMESCO Finland
Right side
2.0
14.8
220
1318
CGG35
NOMESCO Finland
Transplantation of endothelium of cornea
+∞
14.6
14
*
S01XA18
ATC
ciclosporin; ophthalmic
15.8
14.5
23
15
XCH00
NOMESCO Finland
Eye pressure measurement
3.4
14.3
52
160
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
14.2
321
2203
H57.1
ICD-10 Finland
Ocular pain
4.0
14.1
41
108
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
13.6
13
*
S01AD03
ATC
aciclovir; ophthalmic
4.2
13.4
36
89
Z2221
NOMESCO Finland
Medical doctor
2.0
13.4
207
1249
S01EE01
ATC
latanoprost; ophthalmic
3.0
13.3
62
221
H26.2
ICD-10 Finland
Complicated cataract
10.3
13.1
25
25
H16.2
ICD-10 Finland
Keratoconjunctivitis
71.3
12.6
14
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
3.5
12.5
44
132
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
12.5
12
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
12.5
12
*
H11.0
ICD-10 Finland
Pterygium
13.5
12.5
21
16
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
5.6
12.2
23
42
H40.0
ICD-10 Finland
Glaucoma suspect
2.5
12.0
77
325
H3603, E103,
ICD-10 Finland
66.1
11.6
13
*
S01EC04
ATC
brinzolamide; ophthalmic
3.4
11.6
43
134
S01EA03
ATC
apraclonidine; ophthalmic
11.4
11.1
20
18
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
11.0
270
1859
S01FA02
ATC
scopolamine; ophthalmic
44.1
10.9
13
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
12.2
10.9
19
16
S01FA01
ATC
atropine; ophthalmic
28.5
10.8
14
5
H26.02
ICD-10 Finland
Presenil cataract
4.0
10.7
30
77
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
10.4
10
*
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.7
10.4
56
216
114
Kela drug reimbursment
Glaucoma
2.4
10.4
77
347
ZXE00
NOMESCO Finland
One hour or less
1.7
10.1
266
1856
L17
ICPC
Foot/toe symptom/complaint
1.7
9.6
226
1525
E85.80
ICD-10 Finland
Meretoja sick
+∞
9.4
9
*
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
9.4
9
*
H54.4
ICD-10 Finland
Blindness, monocular
22.1
9.4
13
6
F29
ICPC
Eye symptom/complaint other
2.1
9.1
86
430
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
37.2
9.0
11
*
H27.0
ICD-10 Finland
Aphakia
18.9
9.0
13
7
S01AA01
ATC
chloramphenicol; ophthalmic
2.9
8.7
40
142
H16.8
ICD-10 Finland
Other keratitis
91.2
8.4
9
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
91.2
8.4
9
*
L04AA01
ATC
[U] ciclosporin
6.8
8.4
20
30
3604
FHL
Penetration of the cornea
+∞
8.3
8
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
8.3
98
531
H15.1
ICD-10 Finland
Episcleritis
14.7
8.2
13
9
H43.1
ICD-10 Finland
Vitreous haemorrhage
4.0
8.2
23
59
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
7.7
8.2
18
24
F01
ICPC
Eye pain
3.7
8.2
26
73
ZXD20
NOMESCO Finland
Day surgery
2.0
8.1
97
528
Z71.8
ICD-10 Finland
Other specified counselling
1.6
8.0
232
1638
H35.36
ICD-10 Finland
Macular cyst
13.2
7.9
13
10
S01EE05
ATC
tafluprost; ophthalmic
2.8
7.7
38
140
H01.0
ICD-10 Finland
Blepharitis
2.4
7.7
53
231
S01KA02
ATC
hypromellose; ophthalmic
4.1
7.7
21
53
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
7.6
197
1351
J01FA10
ATC
azithromycin; systemic
1.6
7.5
366
2913
CHC05
NOMESCO Finland
Iridotomy
4.5
7.5
18
41
Z97.0
ICD-10 Finland
Presence of artificial eye
81.0
7.4
8
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
81.0
7.4
8
*
CGF10
NOMESCO Finland
Suture of laceration of cornea
+∞
7.3
7
*
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
7.3
7
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
7.3
7
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
7.3
7
*
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
7.3
7
*
S01EC03
ATC
dorzolamide; ophthalmic
6.3
7.3
18
29
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.4
7.3
18
42
A98
ICPC
Health maint/preventive medicine
3.6
7.2
645
6044
L28
ICPC
Limited function/disability (L)
1.7
7.2
143
910
F05
ICPC
Visual disturbance other
3.2
7.2
28
90
CGE55
NOMESCO Finland
Excision of pterygium with transplanation of conjunctiva
20.3
7.1
10
5
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.3
7.1
52
233
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.8
7.1
34
124
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
7.1
244
1787
H33.0
ICD-10 Finland
Retinal detachment with retinal break
3.2
6.9
27
87
H02.3
ICD-10 Finland
Blepharochalasis
2.2
6.9
57
269
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
8.4
6.9
14
17
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
3.2
6.8
26
83
S01AA12
ATC
tobramycin; ophthalmic
40.5
6.8
8
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
40.5
6.8
8
*
H20
ICD-10 Finland
Iridocyclitis
16.9
6.8
10
6
R4110
NOMESCO Finland
Physiotherapy
1.6
6.7
195
1368
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
22.8
6.7
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
6.6
255
1907
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
2.3
6.5
47
210
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
70.5
6.4
7
*
CHD99
NOMESCO Finland
Other filtering operation
14.5
6.4
10
7
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
4.1
6.4
17
42
R05
ICPC
Cough
1.6
6.4
170
1167
H16.3
ICD-10 Finland
Interstitial and deep keratitis
+∞
6.3
6
*
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
+∞
6.3
6
*
CGG11
NOMESCO Finland
Corneal cross-linking
+∞
6.3
6
*
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
26.9
6.2
8
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
12.7
6.1
10
8
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.6
6.1
178
1247
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
391
2846
1.91
14.53
2.6
2.5
80.43
78.77
nmol/l
0.60
341
2549
384
2923
1.75
10.93
7.4
6.2
1.22
1.21
mmol/l
1.48
353
2680
371
2801
1.74
10.84
2.4
2.2
102.82
97.38
pmol/l
0.93
181
1441
413
3219
1.75
10.71
8.3
7.1
1.22
1.21
mmol/l
2.25
355
2770
366
2791
1.70
9.97
4.5
4.8
36.00
35.48
g/l
1.09
330
2628
160
1000
1.79
8.76
3.3
3.1
2.27
3.00
e6/l
0.39
81
484
522
4480
1.78
8.36
5.4
4.5
13.77
12.67
mm/h
0.91
486
4173
625
5724
2.64
8.10
5.4
5.3
4.59
4.66
mmol/l
0.85
565
5291
21
53
4.06
7.66
1.6
1.4
—
—
—
0
0
536
4673
1.77
7.66
8.4
8.4
76.67
79.47
u/l
0.87
509
4430
629
5803
2.68
7.56
6.3
6.1
2.61
2.70
mmol/l
1.70
564
5353
620
5698
2.39
7.25
5.4
5.2
1.51
1.51
mmol/l
0.07
559
5239
164
1090
1.67
7.04
3.3
2.9
0.58
1.17
e6/l
3.20
87
577
350
2785
1.54
6.96
3.6
3.0
110.96
123.97
ug/l
0.57
328
2575
421
3496
1.56
6.86
9.9
9.9
4.08
4.05
e9/l
0.07
362
3060
215
1554
1.57
6.47
4.7
4.0
92.10
90.87
%
0.32
209
1526
53
251
2.21
6.39
1.9
2.4
43.40
38.63
u/l
0.74
45
221
174
1216
1.58
5.99
4.1
4.1
252.99
348.36
ng/l
0.44
144
982
88
518
1.81
5.76
4.6
3.5
91.79
82.72
ng/l
0.57
76
450
639
6025
2.74
5.76
14.5
12.7
24.32
25.17
u/l
0.65
617
5840
286
2244
1.48
5.69
3.2
3.6
2.37
2.36
mmol/l
1.22
255
2021
592
5430
1.85
5.68
6.4
5.7
1.87
1.94
mu/l
0.65
549
4962
16
34
4.80
5.33
1.4
1.2
—
—
—
0
0
646
6146
3.11
5.30
30.1
25.4
91.69
91.37
fl
1.00
639
6082
646
6146
3.11
5.30
30.2
25.4
253.87
250.73
e9/l
0.63
635
6030
646
6148
3.10
5.25
30.9
25.9
39.73
40.03
%
0.82
639
6080
646
6148
3.10
5.25
30.1
25.4
4.40
4.44
e12/l
1.31
633
6010
646
6151
3.08
5.19
30.4
25.6
132.34
133.79
g/l
1.85
640
6086
596
5506
1.83
5.19
7.3
6.7
39.95
39.42
mmol/mol
0.69
554
5141
230
1756
1.47
5.13
3.7
3.2
0.28
0.40
e6/l
0.77
165
1278
213
1608
1.48
5.01
2.5
2.3
2.54
2.97
mg/l
2.06
183
1378
638
6050
2.50
4.95
25.9
22.0
79.64
76.15
umol/l
1.06
628
5982
243
1901
1.44
4.68
1.8
1.7
20.67
20.67
nmol/l
0.00
199
1586
610
5705
1.88
4.68
19.8
16.4
22.74
23.87
mg/l
0.43
518
4694
589
5457
1.72
4.61
4.5
4.4
1.25
1.28
mmol/l
0.40
522
4968
256
2033
1.42
4.50
3.8
3.3
31.50
81.32
e6/l
0.80
197
1550
624
5903
1.99
4.25
23.8
19.7
3.97
3.97
mmol/l
0.24
610
5777
622
5895
1.91
3.95
23.4
19.6
139.65
139.70
mmol/l
0.22
607
5781
378
3255
1.38
3.93
4.2
4.1
0.00
0.49
estimate
0.53
64
635
104
711
1.55
3.84
2.3
2.6
4.88
7.53
umol/l
3.18
90
635
370
3190
1.36
3.74
4.1
4.0
0.00
0.00
estimate
0.50
64
662
60
360
1.73
3.71
2.9
3.4
4.43
4.54
pmol/l
0.37
55
315
373
3223
1.36
3.70
4.2
4.1
0.00
5.17
estimate
0.80
69
678
510
4639
1.43
3.68
5.0
4.6
15.12
14.89
pmol/l
1.38
470
4229
117
831
1.50
3.62
7.5
5.1
1.01
1.03
mmol/l
0.43
107
754
594
5583
1.62
3.55
20.2
16.1
77.76
78.37
ml/min/173m2
0.29
556
5200
43
240
1.85
3.39
1.4
2.6
0.45
0.96
g/l
0.74
37
212
376
3281
1.34
3.35
2.8
2.8
—
—
—
0
0
110
798
1.45
3.05
1.7
1.9
—
—
—
0
0
168
1314
1.37
3.04
2.8
2.9
2.47
2.46
mmol/l
0.72
149
1195
406
3613
1.32
3.00
5.2
4.9
6.70
6.69
mmol/l
0.07
391
3450
134
1014
1.40
2.95
3.5
2.4
2.29
2.33
g/l
0.28
125
944
33
178
1.90
2.92
4.4
3.0
2.00
2.15
index
0.05
14
81
29
151
1.96
2.84
1.3
1.3
—
—
—
0
0
83
578
1.50
2.83
2.8
2.3
43.25
37.33
u/l
0.23
71
480
592
5617
1.51
2.73
5.9
5.4
5.96
5.95
mmol/l
0.09
533
5123
139
1072
1.38
2.73
1.7
1.7
1154.19
1206.04
nmol/l
0.25
101
789
43
259
1.71
2.68
1.4
2.4
2.98
3.00
g/l
0.04
37
236
15
61
2.49
2.63
5.9
2.9
10.63
12.55
index
—
8
33
79
556
1.48
2.57
8.6
6.5
9.36
9.34
mmol/l
0.01
74
533
139
1083
1.36
2.55
3.6
2.4
12.88
12.81
umol/l
0.04
128
1011
297
2577
1.28
2.48
2.0
2.0
1.27
1.33
mmol/l
0.79
253
2153
186
1520
1.31
2.47
2.5
2.4
—
—
—
0
0
370
3307
1.27
2.39
5.1
6.6
10.45
11.26
umol/l
1.19
346
3159
44
276
1.64
2.38
1.4
2.4
7.51
7.48
g/l
0.03
38
253
44
276
1.64
2.38
1.4
2.4
4.05
4.24
g/l
0.79
38
253
9
28
3.24
2.31
2.6
4.0
637.11
1007.82
u/ml
—
9
28
10
34
2.97
2.29
1.5
3.1
62.70
162.21
nmol/l
—
10
34
149
1194
1.32
2.26
1.4
1.3
25.82
34.54
iu/ml
0.39
54
367
39
243
1.64
2.18
1.4
2.4
10.41
10.84
g/l
0.31
32
218
254
2189
1.26
2.17
4.1
3.3
6.73
7.08
mmol/l
0.78
217
1829
99
751
1.37
2.15
1.7
1.9
—
—
—
0
0
43
276
1.60
2.14
1.4
2.4
3.93
3.61
g/l
1.27
38
253
57
391
1.50
2.13
2.5
2.6
30.63
19.08
au/ml
—
6
28
236
2026
1.26
2.07
2.8
3.1
31.22
32.57
u/l
0.12
222
1922
55
378
1.50
2.04
1.4
1.3
375.16
207.60
u/ml
0.61
48
353
130
1044
1.31
1.94
1.8
2.0
—
—
—
0
0
21
113
1.89
1.93
1.4
1.3
—
—
—
0
0
21
113
1.89
1.93
1.4
1.3
—
—
—
0
0
26
151
1.75
1.89
1.7
1.6
—
—
—
0
0
165
1371
1.27
1.89
1.4
1.3
0.89
1.64
u/ml
1.07
36
372
33
207
1.63
1.83
1.3
1.3
—
—
—
0
0
5
12
4.19
1.82
1.0
1.0
—
—
—
0
0
168
1407
1.26
1.79
2.8
2.6
6.07
6.17
e6/l
0.03
150
1287
20
109
1.86
1.79
1.3
1.3
—
—
—
0
0
40
265
1.54
1.78
1.4
1.6
8.40
8.38
iu/ml
—
5
63
247
2161
1.23
1.77
4.6
4.1
6.04
8.40
mg/mmol
0.86
145
1296
119
958
1.30
1.74
3.9
2.4
21.71
22.02
%
0.11
108
896
228
1983
1.23
1.73
3.1
3.2
1169.27
1157.23
ng/l
0.02
195
1695
53
376
1.45
1.71
2.6
2.4
12.61
12.80
nmol/l
0.06
43
338
31
196
1.61
1.68
1.2
2.4
0.00
0.00
g/l
-0.00
31
183
27
165
1.66
1.67
2.1
2.5
12.83
12.62
mg/l
0.04
27
150
137
1130
1.27
1.66
1.4
1.3
17.98
13.89
u/ml
0.18
37
416
29
181
1.63
1.66
1.2
1.4
317.95
292.31
ug/g
0.23
16
108
34
221
1.57
1.65
2.2
3.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
29
183
1.61
1.60
2.1
2.7
0.37
0.36
iu/ml
0.07
12
110
131
1084
1.26
1.55
2.7
3.2
0.81
0.82
mmol/l
0.36
123
1020
8
33
2.44
1.54
8.1
3.0
0.50
0.91
index
—
8
33
226
1985
1.21
1.52
2.2
2.1
131.31
219.35
u/l
1.58
217
1884
66
498
1.36
1.52
2.7
2.8
68.30
63.55
ml/min/173m2
0.38
23
214
33
218
1.54
1.52
1.3
1.4
39.53
29.89
iu/l
0.75
26
180
31
202
1.56
1.51
1.6
3.7
1.25
2.92
ratio
2.17
20
121
31
202
1.56
1.51
1.3
1.2
—
13.23
—
0
12
54
396
1.40
1.48
1.6
1.7
—
—
—
0
0
27
172
1.59
1.45
1.4
1.5
—
—
—
0
0
181
1567
1.21
1.41
2.9
2.8
342.72
339.51
umol/l
0.16
160
1369
26
169
1.56
1.30
1.8
1.9
5.80
39.63
iu/l
0.48
13
67
26
170
1.55
1.28
1.5
1.7
9977.61
16757.57
e6/l
0.72
18
122
27
179
1.53
1.25
2.3
2.3
97.37
92.36
%
0.84
27
173
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
19
2.64
1.22
4.0
2.6
139.60
117.32
%
—
5
19
8
38
2.12
1.18
1.5
1.5
7.22
5.71
u/l
—
8
30
26
174
1.51
1.17
1.4
1.5
—
—
—
0
0
311
2862
1.16
1.16
2.8
2.8
—
—
estimate
—
0
0
8
40
2.01
1.12
1.3
1.1
—
90.00
—
0
9
10
51
1.98
1.11
1.0
1.1
87.50
93.78
%
—
10
45
60
472
1.30
1.09
2.1
1.6
—
—
—
0
0
5
22
2.28
1.03
2.0
2.5
0.61
0.60
mmol/l
—
5
22
317
2942
1.15
1.01
14.3
13.8
1.26
1.23
inr
0.31
268
2444
19
123
1.56
1.00
2.6
1.5
20.54
11.14
u/l
0.43
12
97
7
35
2.01
1.00
1.4
2.1
—
—
—
0
0
14
84
1.68
0.98
1.1
1.1
1.05
1.87
u/ml
—
7
38
0
29
0.00
0.98
0.0
2.5
—
48.27
—
0
24
75
617
1.24
0.97
2.2
2.0
357.53
378.21
nmol/l
0.42
64
570
406
3844
1.15
0.94
3.2
3.3
41.05
50.47
u/l
2.42
382
3595
107
917
1.20
0.94
3.4
3.3
0.76
0.79
ug/l
0.14
80
592
68
557
1.25
0.92
1.7
3.1
64.72
66.91
g/l
1.23
57
516
6
28
2.15
0.91
1.5
1.4
—
—
—
0
0
104
895
1.19
0.88
1.5
1.5
—
—
—
0
0
94
807
1.19
0.82
5.8
5.0
33.04
32.51
%
0.17
53
508
8
47
1.71
0.81
1.0
1.1
—
—
—
0
0
0
25
0.00
0.79
0.0
1.6
—
7.66
—
0
25
8
48
1.67
0.79
1.1
1.5
—
23.00
—
0
7
8
48
1.67
0.79
1.0
1.1
—
—
—
0
0
13
82
1.60
0.78
1.0
1.1
3.29
6.30
u/ml
—
7
33
153
1373
1.15
0.78
1.8
1.7
1.74
1.28
mg/l
0.53
125
1070
0
27
0.00
0.77
0.0
1.2
—
10.00
—
0
27
72
607
1.21
0.77
4.3
3.3
1.99
1.77
mmol/l
0.19
61
514
168
1520
1.14
0.76
5.9
5.7
2.09
2.43
ug/l
0.49
153
1365
5
24
2.09
0.74
1.4
2.1
36.86
40.91
g/l
—
5
24
23
167
1.39
0.74
1.1
1.1
—
—
—
0
0
5
25
2.01
0.73
1.8
1.9
108.40
107.40
%
—
5
25
29
220
1.33
0.72
1.3
1.5
0.23
0.37
mg/l
1.01
11
93
12
76
1.59
0.72
1.0
1.1
—
—
—
0
0
7
41
1.71
0.70
1.0
1.3
5.31
6.19
u/l
—
7
33
59
494
1.21
0.69
1.5
1.5
—
—
—
0
0
11
69
1.60
0.68
1.1
1.1
123.91
117.16
%
0.27
11
63
5
27
1.86
0.68
1.0
1.0
—
—
—
0
0
106
939
1.15
0.65
1.4
1.4
—
—
—
0
0
5
29
1.73
0.64
2.8
4.8
—
—
—
0
0
21
155
1.37
0.63
1.9
1.2
—
—
—
0
0
8
49
1.64
0.62
1.0
1.1
—
—
—
0
0
8
49
1.64
0.62
1.0
1.1
—
—
—
0
0
35
281
1.26
0.61
1.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
18
131
1.38
0.59
1.4
1.4
4.00
54.84
e6/l
0.58
13
98
28
219
1.29
0.59
1.6
1.5
30.57
15.45
u/ml
—
8
35
47
393
1.21
0.57
1.8
1.8
3.50
3.50
mmol/l
0.01
34
298
22
167
1.33
0.57
1.1
1.1
—
—
—
0
0
134
1219
1.12
0.57
4.3
4.8
22.96
21.13
%
0.74
67
603
8
55
1.46
0.56
1.0
1.1
—
—
—
0
0
25
195
1.29
0.55
2.0
1.7
—
—
—
0
0
6
40
1.50
0.51
1.0
1.7
68.50
84.83
ng/l
—
6
40
27
215
1.27
0.51
1.4
1.3
—
—
—
0
0
13
178
0.72
0.49
1.4
1.2
—
—
—
0
0
22
172
1.29
0.48
2.2
1.8
—
—
—
0
0
11
76
1.45
0.48
1.2
1.6
—
—
—
0
0
25
200
1.26
0.47
2.6
1.9
—
—
—
0
0
13
94
1.39
0.46
1.1
1.1
3.53
18.19
au/ml
—
6
30
7
49
1.43
0.46
1.3
1.6
—
—
—
0
0
23
183
1.27
0.45
1.8
1.5
0.06
0.11
iu/ml
—
5
30
61
536
1.15
0.45
2.2
2.0
3.17
3.45
ratio
1.19
46
440
38
324
1.18
0.41
1.4
1.4
—
—
—
0
0
8
59
1.36
0.41
1.0
1.1
—
—
—
0
0
64
717
0.88
0.41
4.3
4.3
3.81
27.97
ug/l
1.41
46
601
8
61
1.32
0.39
3.3
4.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
36
1.39
0.38
1.4
1.1
—
—
—
0
0
6
43
1.40
0.35
1.2
1.3
—
—
—
0
0
6
43
1.40
0.35
1.2
1.3
—
—
—
0
0
207
1971
1.07
0.35
2.6
2.5
57.93
62.14
u/l
0.30
187
1828
6
44
1.37
0.34
1.3
1.4
—
62.00
—
0
5
6
47
1.28
0.32
1.3
1.5
—
480.00
—
0
6
65
590
1.11
0.32
1.7
1.7
1.48
1.51
%
0.10
58
506
34
295
1.16
0.32
1.8
1.9
1.58
1.52
g/l
0.11
29
264
56
504
1.12
0.32
1.5
2.2
8.73
7.36
ug/l
0.16
44
447
19
156
1.22
0.31
1.2
1.4
595.47
521.11
mg/l
0.22
19
148
11
84
1.31
0.30
1.4
1.4
—
—
—
0
0
11
84
1.31
0.30
1.4
1.4
—
—
—
0
0
11
85
1.30
0.28
1.4
1.4
—
—
—
0
0
36
406
0.88
0.28
1.9
1.8
—
—
—
0
0
8
63
1.27
0.28
1.0
1.2
—
—
—
0
0
17
140
1.22
0.27
2.8
2.5
14.90
80.22
ug/min
—
5
86
14
172
0.81
0.27
1.6
1.5
—
—
—
0
0
138
1311
1.07
0.26
1.9
1.7
428.94
17542655.80
pmol/l
1.06
114
1066
19
160
1.19
0.25
1.2
1.6
—
—
—
0
0
79
735
1.08
0.25
8.4
7.7
1.44
1.05
mmol/l
0.44
71
622
45
408
1.11
0.24
1.0
1.2
108.99
138.02
u/ml
0.17
12
170
78
728
1.08
0.23
6.5
7.1
—
—
—
0
0
5
38
1.32
0.23
1.0
2.2
—
—
—
0
0
5
39
1.28
0.23
1.0
1.0
—
—
—
0
0
11
88
1.25
0.22
1.4
1.5
—
—
—
0
0
11
88
1.25
0.22
1.4
1.4
—
—
—
0
0
11
88
1.25
0.22
1.4
1.4
—
—
—
0
0
11
88
1.25
0.22
1.4
1.4
—
—
—
0
0
5
42
1.19
0.21
1.2
1.6
56.36
47.14
ug/l
—
5
42
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
8.1
—
10.44
—
0
10
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
12
144
0.83
0.20
1.1
1.1
0.51
0.68
ratio
—
5
25
6
50
1.20
0.19
1.0
1.0
870.50
632.64
ng/l
—
6
33
6
50
1.20
0.19
1.0
1.0
—
—
—
0
0
6
50
1.20
0.19
1.0
1.0
48.17
37.48
ng/l
—
6
31
6
50
1.20
0.19
1.0
1.0
326.33
277.50
ng/l
—
6
32
36
328
1.10
0.19
2.6
2.4
0.53
0.61
%
1.39
36
328
7
58
1.21
0.18
1.3
1.1
—
—
—
0
0
147
1418
1.05
0.17
4.4
4.3
1.02
1.02
kg/l
1.17
109
957
10
82
1.22
0.17
1.0
1.0
—
—
—
0
0
5
67
0.74
0.17
1.6
2.0
—
—
—
0
0
5
70
0.71
0.16
2.2
2.5
1.22
1.19
mmol/l
—
5
70
5
70
0.71
0.16
2.2
2.5
108.60
105.57
mmol/l
—
5
70
16
140
1.15
0.15
1.3
1.3
3.62
3.83
mmol/l
0.43
16
131
23
207
1.12
0.15
1.7
1.5
—
—
—
0
0
186
1811
1.04
0.14
4.3
4.2
0.00
0.01
estimate
1.15
62
617
168
1726
0.96
0.14
3.3
3.6
0.00
0.06
estimate
0.66
52
520
28
259
1.08
0.11
1.2
1.3
—
—
—
0
0
14
157
0.89
0.11
1.0
1.6
—
—
—
0
0
53
505
1.05
0.10
5.0
3.7
1.23
1.23
mmol/l
0.21
43
435
62
647
0.95
0.10
3.4
3.2
—
—
—
0
0
21
227
0.92
0.09
2.1
2.0
—
—
—
0
0
5
63
0.79
0.08
1.6
2.1
—
—
—
0
0
20
215
0.93
0.07
1.9
1.8
—
—
—
0
0
8
77
1.04
0.07
1.0
1.1
—
120.06
—
0
18
35
367
0.95
0.07
1.8
1.8
—
—
—
0
0
34
355
0.96
0.06
2.9
3.4
1.83
2.00
mmol/l
0.11
24
270
16
169
0.95
0.03
1.3
1.7
—
—
—
0
0
39
400
0.97
0.02
2.4
2.9
122.69
126.67
g/l
0.45
39
390
12
128
0.94
0.02
1.1
1.5
—
—
—
0
0
17
163
1.04
0.01
1.2
1.2
0.89
0.91
g/l
0.10
17
163
242
2427
1.00
0.00
4.0
4.0
0.02
0.04
estimate
0.42
51
540
10
105
0.95
0.00
1.1
1.5
—
—
—
0
0
15
145
1.04
0.00
1.4
1.4
—
—
—
0
0
12
124
0.97
0.00
3.6
2.7
9.07
8.07
pmol/l
0.11
12
124
15
154
0.97
0.00
1.1
1.1
1.55
1.59
g/l
0.33
15
154
14
143
0.98
0.00
1.1
1.5
—
—
—
0
0
12
122
0.98
0.00
3.9
3.8
30.17
2401.82
u/ml
0.65
12
117
239
2394
1.00
0.00
4.1
3.8
69.03
69.76
ng/l
0.01
176
1781
11
109
1.01
0.00
1.5
1.9
—
—
—
0
0
15
149
1.01
0.00
1.6
2.0
126.89
128.14
g/l
—
9
111
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
1.8
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
7.3
—
—
—
0
0
9
95
0.95
-0.00
5.2
5.4
369.33
358.78
umol/l
—
9
89
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
95
0.95
-0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.2
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
-0.00
1.3
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
1.2
1.1
138.80
101.93
pmol/l
—
5
54
0
5
0.00
-0.00
0.0
1.6
—
6.04
—
0
5
9
96
0.94
-0.00
1.2
1.3
—
342.00
—
0
10
0
5
0.00
-0.00
0.0
1.0
—
50.80
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
-0.00
1.3
1.6
—
—
—
0
0
12
120
1.00
-0.00
1.1
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALDYSTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDYSTROPHY | 1.201 [1.0, 1.44] | 0.048 |
| Birth year | 0.994 [0.99, 1.0] | 0.189 |
During the follow-up period (1.1.1998 — 31.12.2019), 286 out of 1316 females with H7_CORNEALDYSTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDYSTROPHY | 1.171 [0.91, 1.51] | 0.228 |
| Birth year | 0.993 [0.98, 1.0] | 0.137 |
During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 781 males with H7_CORNEALDYSTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALDYSTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | 0.305% |
| 5 | 0.783% | 1.513% |
| 10 | 1.754% | 3.959% |
| 15 | 3.484% | 7.537% |
| 20 | 5.907% | 13.452% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALDYSTROPHY – Corneal degeneration
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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