No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
348 |
4. Check minimum number of eventsNone |
348 |
5. Include endpointsNone |
348 |
6. Filter based on genotype QC (FinnGen only) |
302 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Keratopathia bullosa
Similar endpoints
↥List of similar endpoints to
Bullous keratopathy
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Keratitis
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2359 | 1387 | 961 |
| Only index persons | 2101 | 1236 | 865 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 73.68 | 76.86 | 69.05 |
| Only index persons | 72.48 | 75.69 | 67.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 302 | 176 | 126 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 71.06 | 71.20 | 70.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 314
- Matched controls
- 3140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
307.7
314
*
H16.0
ICD-10 Finland
Corneal ulcer
90.6
220.4
119
21
S01ED01
ATC
timolol; ophthalmic
30.6
158.4
116
59
S01EA05
ATC
brimonidine; ophthalmic
39.6
146.5
95
34
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
129.4
115
*
S01EC01
ATC
acetazolamide; systemic
33.5
126.4
86
35
Z96.1
ICD-10 Finland
Presence of intraocular lens
13.1
119.4
212
430
S01ED51
ATC
timolol, combinations; ophthalmic
13.5
111.7
136
168
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
57.2
111.1
64
14
WX140
NOMESCO Finland
Parabulbar anesthesy
15.3
97.3
99
92
114
Kela drug reimbursment
Glaucoma
9.5
84.3
136
233
S01EA03
ATC
apraclonidine; ophthalmic
42.3
76.4
47
13
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
76.2
70
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
14.8
74.3
280
1122
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
+∞
73.9
68
*
S01EX03, ,
ATC
20.1
71.2
58
35
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
70.5
65
*
S01EE01
ATC
latanoprost; ophthalmic
9.4
66.4
96
141
TCG10
NOMESCO Finland
Removal of sutures from cornea
735.0
63.1
60
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
8.4
62.4
250
997
S01EC04
ATC
brinzolamide; ophthalmic
11.4
59.2
69
76
S01EC03
ATC
dorzolamide; ophthalmic
22.7
59.2
45
23
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.2
58.9
114
229
S01BC03
ATC
diclofenac; ophthalmic
19.8
56.8
46
27
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
332.0
56.1
55
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
118.1
55.0
58
6
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
+∞
53.7
50
*
S01EE04
ATC
travoprost; ophthalmic
17.2
53.0
46
31
XCK10
NOMESCO Finland
Photography of fundus of eye
6.9
52.2
102
205
XCK00
NOMESCO Finland
Perimetry
8.2
51.8
80
125
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
296.1
50.7
50
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
11.2
49.6
57
61
H18.2
ICD-10 Finland
Other corneal oedema
+∞
48.2
45
*
S01AD03
ATC
aciclovir; ophthalmic
13.6
47.4
47
40
H16.9
ICD-10 Finland
Keratitis, unspecified
275.2
47.4
47
*
S01BA07
ATC
fluorometholone; ophthalmic
20.8
47.2
37
20
S01BA04
ATC
prednisolone; ophthalmic
16.8
45.9
40
27
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
41.6
39
*
S01BA01
ATC
dexamethasone; ophthalmic
10.6
41.5
49
54
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.9
38.6
118
344
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.7
38.5
89
205
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
38.3
36
*
S01EE05
ATC
tafluprost; ophthalmic
8.8
36.8
50
66
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
35.7
122
385
H18.8
ICD-10 Finland
Other specified disorders of cornea
375.7
34.6
34
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
7.0
34.3
58
98
CG2S4
NOMESCO Finland
Photography of cornea
183.7
32.4
33
*
XCH00
NOMESCO Finland
Eye pressure measurement
7.0
32.3
54
90
Z3229
NOMESCO Finland
Other healthcare associate professional
5.3
32.1
77
181
H04.10
ICD-10 Finland
Dry eye syndrome
5.2
30.7
75
179
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
29.7
28
*
H18.6
ICD-10 Finland
Keratoconus
+∞
29.7
28
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.0
28.8
220
1167
CKD60
NOMESCO Finland
Anterior vitrectomy
28.6
28.2
38
15
H40.0
ICD-10 Finland
Glaucoma suspect
5.0
26.5
66
159
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
66.0
26.5
30
5
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
26.4
25
*
S01EE03
ATC
bimatoprost; ophthalmic
8.7
25.6
34
43
H33.0
ICD-10 Finland
Retinal detachment with retinal break
7.7
24.3
36
52
S01AX11
ATC
[U] ofloxacin
6.3
23.2
42
75
H57.1
ICD-10 Finland
Ocular pain
8.6
22.5
30
38
H18.4
ICD-10 Finland
Corneal degeneration
+∞
22.1
21
*
H27.0
ICD-10 Finland
Aphakia
64.7
21.2
24
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
21.1
20
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.8
20.7
76
243
WX142
NOMESCO Finland
Sub-tenon anesthesy
38.6
20.2
25
7
CGF10
NOMESCO Finland
Suture of laceration of cornea
+∞
20.0
19
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
30.0
19.0
25
9
H40.9
ICD-10 Finland
Glaucoma, unspecified
8.0
18.5
26
35
S01AA01
ATC
chloramphenicol; ophthalmic
5.1
18.1
41
90
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
17.9
17
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
17.9
17
*
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
190.3
17.7
18
*
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
4.8
17.5
43
101
H26.2
ICD-10 Finland
Complicated cataract
27.4
17.2
23
9
ZXA10
NOMESCO Finland
Bilateral
2.9
16.9
106
464
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.6
16.7
43
105
CFD10
NOMESCO Finland
Repair of conjunctiva
179.1
16.7
17
*
S01ED02
ATC
betaxolol; ophthalmic
15.4
16.7
27
19
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.9
16.4
39
89
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
7.6
16.3
24
34
ZXA05
NOMESCO Finland
Left side
2.7
16.0
124
604
ZXD20
NOMESCO Finland
Day surgery
3.3
15.4
68
242
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
15.4
172
999
H26.4
ICD-10 Finland
After-cataract
3.1
15.3
76
290
WX002
NOMESCO Finland
Sedation and analgesia
2.8
15.2
97
426
S01FA04
ATC
cyclopentolate; ophthalmic
33.6
15.0
19
6
CHD99
NOMESCO Finland
Other filtering operation
33.6
15.0
19
6
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
59.7
14.9
17
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
15.2
14.8
24
17
ZXC20
NOMESCO Finland
Use of chemical agents
6.8
14.3
23
36
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.6
14.2
28
54
S01EB01
ATC
pilocarpine; ophthalmic
16.8
14.1
22
14
S01EA02
ATC
dipivefrine; ophthalmic
56.0
13.9
16
*
ZXA00
NOMESCO Finland
Right side
2.5
13.9
128
671
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
13.6
13
*
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
146.1
13.6
14
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
22.4
13.5
19
9
CHC05
NOMESCO Finland
Iridotomy
11.7
13.3
24
22
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
25.6
12.6
17
7
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
12.6
12
*
CGD99
NOMESCO Finland
Other operation for error of refraction
+∞
12.6
12
*
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
135.2
12.5
13
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
22.4
12.1
17
8
H54.4
ICD-10 Finland
Blindness, monocular
48.6
12.0
14
*
3604
FHL
Penetration of the cornea
+∞
11.5
11
*
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
+∞
11.5
11
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
11.5
11
*
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
124.4
11.5
12
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
124.4
11.5
12
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
10.6
11.2
21
21
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
11.2
146
873
S01FA01
ATC
atropine; ophthalmic
29.2
10.8
14
5
H54.1
ICD-10 Finland
Severe visual impairment, binocular
113.7
10.5
11
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
10.5
10
*
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
10.5
10
*
CGG35
NOMESCO Finland
Transplantation of endothelium of cornea
+∞
10.5
10
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
10.5
10
*
H35.36
ICD-10 Finland
Macular cyst
33.8
10.4
13
*
H27.1
ICD-10 Finland
Dislocation of lens
24.3
10.3
14
6
XCH05
NOMESCO Finland
Eye pressure longterm registration
15.2
10.1
16
11
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
41.5
10.0
12
*
CD2S4
NOMESCO Finland
Photography of eye
18.2
9.5
14
8
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
103.0
9.5
10
*
CFW99
NOMESCO Finland
Other operation on conjunctiva
22.5
9.4
13
6
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
9.4
9
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
+∞
9.4
9
*
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
9.4
9
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
9.4
9
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
9.4
9
*
H20.8
ICD-10 Finland
Other iridocyclitis
+∞
9.4
9
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
4.4
8.9
23
56
L04AA01
ATC
[U] ciclosporin
14.6
8.8
14
10
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
3.6
8.6
29
86
S01FA02
ATC
scopolamine; ophthalmic
28.4
8.5
11
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
92.4
8.5
9
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
8.9
8.4
17
20
H16.8
ICD-10 Finland
Other keratitis
+∞
8.4
8
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
8.4
8
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
+∞
8.4
8
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
8.2
57
255
S01BC05
ATC
ketorolac; ophthalmic
3.4
8.2
30
94
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
22.7
8.1
11
5
S01KA02
ATC
hypromellose; ophthalmic
6.7
7.8
19
30
Z97.0
ICD-10 Finland
Presence of artificial eye
46.1
7.7
9
*
S01EE51
ATC
latanoprost and netarsudil; ophthalmic
18.9
7.7
11
6
CA1ME
NOMESCO Finland
Ultrasound oculometry
18.9
7.7
11
6
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
7.4
7.6
17
24
H43.1
ICD-10 Finland
Vitreous haemorrhage
6.8
7.5
18
28
37401
ICD-8 Finland
Cataract, Praesenilis
82.0
7.4
8
*
CFB00
NOMESCO Finland
Suture of conjunctiva
82.0
7.4
8
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
7.4
132
854
CGF35
NOMESCO Finland
Repair of cornea using graft
+∞
7.3
7
*
H21.0
ICD-10 Finland
Hyphaema
+∞
7.3
7
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
7.3
7
*
37403
ICD-8 Finland
Cataract, Complicata
+∞
7.3
7
*
S01XA03
ATC
sodium chloride, hypertonic; ophthalmic
+∞
7.3
7
*
CGG20
NOMESCO Finland
Epikeratofakia or keratofakia
+∞
7.3
7
*
3711
FHL
Cyclodiateria or cryocoagulation
+∞
7.3
7
*
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
7.3
7
*
S01AA12
ATC
tobramycin; ophthalmic
20.6
7.2
10
5
3793C
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[PSEUDOPHAKIA]
20.6
7.2
10
5
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
3.0
7.2
33
119
D07AA02
ATC
hydrocortisone; topical
2.4
7.1
53
245
H25.0
ICD-10 Finland
Senile incipient cataract
3.0
7.1
33
120
Z3231
NOMESCO Finland
Registered nurse
2.0
6.9
103
623
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
41.0
6.8
8
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
41.0
6.8
8
*
ZXE00
NOMESCO Finland
One hour or less
1.9
6.8
132
873
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
3.9
6.7
20
54
H34.8
ICD-10 Finland
Other retinal vascular occlusions
4.2
6.7
18
45
H40.8
ICD-10 Finland
Other glaucoma
23.1
6.7
9
*
R06AX13
ATC
loratadine; oral
2.4
6.7
50
231
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
12.6
6.6
11
9
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
6.5
69
368
S05.2
ICD-10 Finland
Ocular laceration and rupture with prolapse or loss of intraocular tissue
71.2
6.4
7
*
CJF20
NOMESCO Finland
Removal of artificial lens
71.2
6.4
7
*
CJF45
NOMESCO Finland
Removal and implantation of artificial lens in anterior chamber with iridectomy or iridotomy
71.2
6.4
7
*
CHD10
NOMESCO Finland
Trabeculectomy
71.2
6.4
7
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
9.5
6.3
12
13
CGG60
NOMESCO Finland
Reinforcement of sclera using graft
+∞
6.3
6
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
6.3
6
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
6.3
6
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
6.3
6
*
H18.3
ICD-10 Finland
Changes in corneal membranes
+∞
6.3
6
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
6.3
6
*
36399
ICD-8 Finland
Keratitis, Without mention of ulcer
+∞
6.3
6
*
S01EX05
ATC
netarsudil; ophthalmic
+∞
6.3
6
*
CJF50
NOMESCO Finland
Removal and implantation of artificial lens in posterior chamber
+∞
6.3
6
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
6.3
6
*
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
5.6
6.2
17
32
H26.02
ICD-10 Finland
Presenil cataract
5.4
6.1
17
33
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
16
10.47
8.63
1.4
1.5
—
—
—
0
0
12
12
10.34
6.59
1.2
1.2
—
—
—
0
0
31
144
2.28
4.08
2.8
4.4
1.54
1.54
%
0.01
31
134
8
10
8.17
4.08
1.1
1.1
—
—
—
0
0
9
14
6.58
4.01
1.1
1.3
—
—
—
0
0
18
66
2.83
3.82
1.7
1.5
—
—
—
0
0
201
1661
1.58
3.68
4.8
4.9
6.93
6.87
mmol/l
0.16
192
1582
176
1420
1.54
3.51
4.4
4.7
0.00
10.81
estimate
0.80
40
324
177
1431
1.54
3.49
4.5
4.7
0.00
1.01
estimate
0.51
34
303
174
1407
1.53
3.39
4.3
4.6
0.00
0.00
estimate
-0.00
38
310
270
2428
1.80
3.28
21.9
18.7
28.44
24.86
mg/l
1.00
245
2074
113
837
1.55
3.27
3.2
3.0
30.17
30.70
u/l
0.09
104
789
23
106
2.26
3.11
2.6
3.0
—
—
—
0
0
221
1902
1.55
3.08
5.1
4.5
14.38
14.51
mm/h
0.05
197
1748
277
2524
1.83
3.02
25.3
23.1
139.42
139.52
mmol/l
0.23
272
2474
277
2529
1.81
2.93
25.5
23.3
3.97
4.01
mmol/l
1.24
272
2478
108
809
1.51
2.91
2.6
2.3
3.32
3.16
mg/l
0.28
97
695
229
2003
1.53
2.81
8.4
8.1
81.49
81.19
u/l
0.04
211
1890
12
41
3.00
2.65
1.3
1.4
—
—
—
0
0
11
37
3.04
2.51
1.1
1.1
—
4.62
—
0
5
7
16
4.45
2.49
1.6
2.2
—
—
—
0
0
79
572
1.51
2.46
1.9
1.7
1.64
1.53
mg/l
0.08
63
468
174
1467
1.42
2.40
6.4
6.8
1.22
1.21
mmol/l
0.11
150
1258
16
71
2.32
2.38
1.5
1.6
220.02
0.15
iu/ml
—
5
17
148
1215
1.41
2.37
3.3
2.8
—
—
estimate
—
0
0
280
2597
1.72
2.36
32.9
28.4
4.30
4.37
e12/l
1.49
272
2541
280
2597
1.72
2.36
32.9
28.4
247.51
242.53
e9/l
0.58
273
2550
132
1071
1.40
2.22
3.2
3.5
2642.08
1513.47
ng/l
0.81
113
926
207
1815
1.41
2.19
5.9
5.7
535.67
3199.16
e6/l
—
6
44
273
2529
1.61
2.14
13.8
12.5
22.88
23.61
u/l
0.43
260
2453
38
241
1.66
2.08
5.9
3.8
1.23
1.23
mmol/l
0.09
30
210
175
1508
1.36
1.96
9.6
8.7
4.33
4.26
e9/l
0.17
159
1326
106
845
1.38
1.93
4.3
4.7
0.00
0.01
estimate
0.50
32
288
110
885
1.37
1.89
2.5
2.6
56.30
58.70
u/l
0.28
97
822
131
1086
1.35
1.86
4.5
4.7
0.00
0.05
estimate
1.63
26
254
58
418
1.48
1.84
1.3
1.3
18.84
41.47
iu/ml
2.60
23
130
154
1311
1.34
1.83
5.8
4.7
34.67
34.87
g/l
0.16
138
1224
118
965
1.36
1.82
4.5
4.1
7.71
9.89
mg/mmol
0.38
75
628
67
504
1.42
1.70
2.3
2.6
2.32
2.29
g/l
0.20
61
461
248
2284
1.41
1.69
6.0
5.6
2.12
2.01
mu/l
0.52
217
2065
46
322
1.50
1.68
8.7
8.5
—
—
—
0
0
214
1928
1.35
1.66
4.7
4.4
15.29
15.11
pmol/l
0.43
189
1729
7
25
2.84
1.66
2.7
2.2
—
—
—
0
0
253
2342
1.41
1.64
20.4
19.0
72.92
72.95
ml/min/173m2
0.01
236
2209
5
14
3.61
1.62
4.6
6.5
—
—
—
0
0
8
32
2.54
1.61
1.0
1.3
—
—
—
0
0
10
43
2.37
1.60
1.4
2.6
1.21
1.20
mmol/l
—
10
43
78
609
1.37
1.59
1.7
1.8
1225.56
1205.22
nmol/l
0.07
56
451
10
44
2.31
1.57
1.4
2.5
104.40
105.45
mmol/l
—
10
44
7
27
2.63
1.52
1.0
1.3
—
—
—
0
0
165
1448
1.29
1.47
19.1
17.6
1.35
1.32
inr
0.21
138
1230
70
544
1.37
1.47
2.5
2.6
12.97
12.14
umol/l
0.42
62
503
25
157
1.64
1.45
2.7
3.0
25.02
25.02
mmol/l
0.00
25
151
86
691
1.34
1.45
3.4
2.9
372.38
352.42
umol/l
0.70
71
590
5
16
3.16
1.44
1.4
1.3
—
—
—
0
0
62
476
1.38
1.40
2.3
2.6
22.11
21.35
%
0.16
56
447
7
29
2.45
1.40
1.1
1.7
—
26.43
—
0
7
54
406
1.40
1.38
4.8
4.7
1.04
1.05
mmol/l
0.07
49
369
153
1339
1.28
1.36
5.4
5.8
1.21
1.21
mmol/l
0.46
141
1221
49
366
1.40
1.30
1.3
1.3
5.52
13.35
u/ml
0.63
24
128
79
637
1.32
1.30
4.3
5.3
1.02
1.02
kg/l
0.04
53
424
251
2351
1.34
1.26
5.7
5.4
4.34
4.48
mmol/l
1.24
222
2153
10
49
2.08
1.23
1.2
1.2
—
—
—
0
0
56
434
1.35
1.20
3.6
5.7
104.98
103.65
mmol/l
1.09
56
434
150
1328
1.25
1.15
2.5
2.3
99.17
94.10
pmol/l
0.62
73
687
167
1498
1.25
1.14
5.7
6.1
11.25
11.59
umol/l
0.22
156
1416
44
331
1.38
1.13
2.5
3.6
5.62
5.80
kpa
0.41
44
316
98
828
1.27
1.12
3.3
3.5
0.46
0.49
e6/l
0.07
77
627
122
1058
1.25
1.12
3.6
3.5
—
—
—
0
0
7
31
2.29
1.11
1.0
1.5
288.29
245.04
u/l
—
7
31
240
2248
1.29
1.10
4.8
4.5
1.26
1.27
mmol/l
0.09
205
2016
107
916
1.26
1.10
1.9
2.1
166.69
199.98
u/l
0.36
101
867
248
2334
1.30
1.09
5.6
5.3
1.46
1.47
mmol/l
0.20
217
2119
74
606
1.29
1.09
4.4
4.3
136.12
240.85
ng/l
0.52
57
529
137
1208
1.24
1.07
4.3
4.3
44.11
107.02
ng/l
0.67
107
946
10
52
1.95
1.07
3.6
3.0
14.03
15.67
%
—
10
52
42
318
1.37
1.05
2.5
3.6
1.49
1.98
mmol/l
0.31
32
265
9
47
1.94
1.03
1.4
1.7
193.00
246.26
pmol/l
—
9
42
247
2329
1.28
1.03
8.6
7.3
41.05
40.37
mmol/mol
0.56
218
2150
40
302
1.37
1.02
4.6
3.6
—
—
—
0
0
7
35
2.02
1.00
1.3
1.4
—
—
—
0
0
5
23
2.19
0.98
1.4
1.5
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
2.71
—
0
12
7
37
1.91
0.94
2.6
6.2
—
160.67
—
0
6
11
63
1.77
0.91
1.5
1.5
—
—
—
0
0
24
169
1.45
0.90
1.3
1.3
—
—
—
0
0
12
71
1.72
0.90
1.3
1.5
—
—
—
0
0
12
71
1.72
0.90
1.3
1.5
—
—
—
0
0
6
29
2.09
0.90
1.2
1.7
—
480.00
—
0
6
10
56
1.81
0.89
5.3
2.7
18.48
9.77
pmol/l
—
10
56
8
44
1.84
0.86
1.3
1.4
—
—
—
0
0
253
2409
1.26
0.86
6.6
6.3
2.41
2.56
mmol/l
1.86
224
2192
8
47
1.72
0.81
1.3
1.6
—
—
—
0
0
15
98
1.56
0.80
1.8
1.4
2.74
9.54
iu/ml
—
5
25
6
33
1.83
0.79
1.3
1.5
—
—
—
0
0
59
490
1.25
0.78
2.4
2.9
0.83
0.81
mmol/l
0.50
54
460
24
175
1.40
0.77
4.2
3.8
2.88
2.16
mmol/l
0.32
17
129
46
372
1.28
0.76
2.0
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
83
1.59
0.76
2.7
2.5
0.31
0.40
iu/ml
—
8
49
21
150
1.43
0.75
6.8
8.2
16.16
15.60
%
0.40
21
144
9
54
1.69
0.75
1.2
1.4
—
—
—
0
0
25
185
1.38
0.74
3.4
3.5
48.20
44.93
%
0.31
25
178
78
672
1.21
0.74
2.0
1.8
93651261.46
21587163.42
pmol/l
0.34
63
542
7
39
1.81
0.73
1.3
1.5
—
—
—
0
0
7
39
1.81
0.73
1.3
1.5
—
—
—
0
0
7
39
1.81
0.73
1.3
1.5
—
—
—
0
0
89
782
1.19
0.69
6.1
5.9
2.47
2.82
ug/l
0.23
75
694
28
216
1.33
0.66
2.6
3.0
67.38
58.60
ml/min/173m2
0.45
13
99
36
288
1.28
0.66
2.2
2.8
4.90
4.21
kpa
0.84
36
275
6
101
0.59
0.63
1.0
2.1
—
—
—
0
0
10
63
1.61
0.62
1.3
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
3.9
—
0.50
—
0
20
35
283
1.27
0.60
2.0
2.7
5.60
6.70
ug/l
0.27
30
251
8
52
1.55
0.60
1.4
1.3
—
—
—
0
0
129
1182
1.16
0.59
3.5
3.1
141.01
127.93
ug/l
0.30
119
1079
7
112
0.62
0.59
1.0
2.2
—
—
—
0
0
10
65
1.56
0.56
3.6
1.8
10.49
13.29
mg/l
—
10
56
6
37
1.63
0.56
1.3
1.6
—
—
—
0
0
6
37
1.63
0.56
1.3
1.6
—
—
—
0
0
6
38
1.59
0.54
1.3
1.6
—
—
—
0
0
104
944
1.15
0.54
2.0
1.8
20.47
20.69
nmol/l
0.04
86
783
61
531
1.18
0.53
2.1
1.9
—
—
—
0
0
246
2371
1.17
0.53
6.4
5.6
6.22
6.09
mmol/l
0.83
218
2136
43
363
1.21
0.52
4.4
6.2
1.36
1.36
mmol/l
0.00
33
303
46
395
1.19
0.47
2.0
1.8
—
—
—
0
0
7
48
1.47
0.47
1.3
1.4
—
—
—
0
0
17
129
1.34
0.47
2.5
2.3
3.41
3.56
g/l
0.25
17
115
85
769
1.14
0.46
4.6
4.0
0.00
0.11
estimate
0.52
28
246
14
186
0.74
0.45
6.9
7.3
23.47
24.66
mmol/l
1.11
14
180
5
31
1.62
0.43
2.6
3.4
—
1337.00
—
0
5
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
13
96
1.37
0.42
1.0
2.3
0.00
0.00
g/l
-0.00
13
87
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
28
234
1.22
0.39
1.4
1.6
—
—
—
0
0
9
69
1.31
0.37
1.4
1.6
—
—
—
0
0
10
72
1.40
0.37
3.8
2.5
3.21
3.39
g/l
—
10
67
69
626
1.13
0.36
4.9
5.0
19.75
21.74
%
0.67
33
325
9
71
1.28
0.36
1.6
1.3
—
—
—
0
0
6
41
1.47
0.36
2.0
2.0
9.50
10.44
mmol/l
—
6
41
30
256
1.19
0.34
2.8
3.9
70.29
86.00
ng/l
0.89
21
220
14
109
1.30
0.34
1.0
2.6
0.00
0.62
g/l
1.82
14
95
129
1219
1.10
0.33
2.8
2.5
79.94
78.55
nmol/l
0.22
110
1074
14
110
1.29
0.32
1.1
1.0
—
—
—
0
0
162
1549
1.09
0.32
3.4
3.3
58.49
53.13
u/l
0.30
146
1434
11
85
1.30
0.28
1.0
2.5
0.00
0.00
g/l
-0.00
11
80
40
357
1.14
0.28
3.8
4.1
223.65
245.23
u/l
1.05
40
332
94
999
0.92
0.27
2.1
1.9
1.25
1.32
mmol/l
0.50
77
817
62
672
0.90
0.27
3.9
3.0
2.46
2.47
mmol/l
0.17
54
596
121
1271
0.92
0.27
2.7
2.6
—
—
—
0
0
72
669
1.10
0.26
2.4
2.3
—
—
—
0
0
60
554
1.10
0.25
1.3
1.3
0.71
1.64
u/ml
1.26
19
147
109
1036
1.08
0.24
3.9
3.3
2.33
2.36
mmol/l
0.87
96
925
24
274
0.87
0.23
4.9
5.9
1.36
1.46
mmol/l
0.22
24
268
5
40
1.25
0.22
1.6
1.4
—
—
—
0
0
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
11
135
0.81
0.22
1.2
1.4
—
38.33
—
0
12
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
172.63
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
37
337
1.11
0.20
5.2
5.3
33.17
32.39
%
0.15
18
216
13
110
1.19
0.17
4.1
2.5
26.24
24.94
mmol/l
0.65
13
110
11
93
1.19
0.14
1.0
2.4
0.00
0.00
g/l
-0.00
11
80
10
85
1.18
0.12
1.3
1.4
—
—
—
0
0
49
464
1.07
0.12
3.1
3.4
2.42
3.15
e6/l
0.30
29
245
25
271
0.92
0.12
3.0
2.7
0.28
0.79
e6/l
0.75
25
259
11
126
0.87
0.11
1.5
3.1
30.18
37.86
u/ml
0.17
11
121
52
495
1.06
0.11
3.2
3.2
0.64
1.32
e6/l
2.12
33
274
20
219
0.91
0.11
1.5
1.4
—
—
—
0
0
33
310
1.07
0.10
2.1
2.4
8.75
8.08
umol/l
0.08
26
269
5
45
1.11
0.10
1.6
1.3
—
—
—
0
0
6
58
1.04
0.08
13.7
2.9
184.83
212.02
%
—
6
53
7
68
1.03
0.08
1.1
1.3
—
—
—
0
0
7
68
1.03
0.08
1.1
1.3
—
—
—
0
0
15
137
1.10
0.07
1.2
1.1
41.20
136.49
u/ml
—
5
46
8
74
1.08
0.07
1.0
1.2
—
—
—
0
0
8
77
1.04
0.07
1.1
1.6
—
—
—
0
0
9
103
0.87
0.06
1.0
1.3
—
—
—
0
0
19
202
0.94
0.05
2.1
1.7
—
—
—
0
0
49
477
1.03
0.04
3.5
3.2
0.55
0.87
ug/l
3.13
33
316
13
122
1.07
0.02
2.2
1.9
—
—
—
0
0
30
291
1.03
0.02
1.6
1.5
—
—
—
0
0
11
117
0.94
0.02
2.4
1.7
—
—
—
0
0
14
133
1.06
0.01
1.9
3.3
13.86
1624.16
u/ml
0.89
14
115
26
253
1.03
0.01
1.8
2.4
32.58
33.82
u/l
0.08
19
206
31
316
0.98
0.00
1.6
1.5
—
—
—
0
0
12
122
0.98
0.00
1.2
1.2
—
—
—
0
0
5
49
1.02
0.00
1.2
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
48.03
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.0
1.1
3.76
4.00
mmol/l
—
5
45
0
8
0.00
-0.00
0.0
1.9
—
1.18
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
8
79
1.01
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
5
59
0.85
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.19
—
0
6
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
8
79
1.01
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
10.14
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
95.00
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H7_BULLKERATOPATHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BULLKERATOPATHY | 1.232 [1.06, 1.43] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.165 |
During the follow-up period (1.1.1998 — 31.12.2019), 547 out of 1262 females with H7_BULLKERATOPATHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BULLKERATOPATHY | 1.031 [0.86, 1.23] | 0.739 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 869 males with H7_BULLKERATOPATHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_BULLKERATOPATHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.201% |
| 5 | 0.61% | 1.199% |
| 10 | 1.702% | 3.042% |
| 15 | 3.265% | 5.816% |
| 20 | 6.012% | 9.836% |
Relationships between endpoints
↥Index endpoint: H7_BULLKERATOPATHY – Bullous keratopathy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data